Research Topics
| NINA STACHENFELDSummaryAffiliation: The John B. Pierce Laboratory Country: USA Publications
Research Grants
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Detail Information
Publications
Blood pressure and water regulation: understanding sex hormone effects within and between men and womenMegan M Wenner
N S Stachenfeld 290 Congress Ave, New Haven, CT 06519, USA
J Physiol 590:5949-61. 2012..Our overarching conclusion is that ovarian hormone exposure is the important underlying factor contributing to differences in blood pressure and water regulation between women and men, and within women throughout the lifespan...- Greater exercise sweating in obese women with polycystic ovary syndrome compared with obese controlsNina S Stachenfeld
The John B Pierce Laboratory, 290 Congress Ave, New Haven, CT 06519, USA
Med Sci Sports Exerc 42:1660-8. 2010..We hypothesized that core temperature (Tc) threshold for sweating during exercise is delayed in women with PCOS and that testosterone delays the Tc set point for sweating during exercise... 
Sex hormone effects on body fluid and sodium regulation in women with and without exercise-associated hyponatremiaNina S Stachenfeld
The John B Pierce Laboratory, Yale University School of Medicine, New Haven, Connecticut 06519, USA
J Appl Physiol 107:864-72. 2009..11 (SD 0.11) liter] compared with no Hypo [0.01 (SD 0.15), 0.03 (SD 17), and -0.16 (SD 0.13) liter for GnRH, E2, and E2-P4, P < 0.05] indicates water retention was the primary contributor to the lower S([Na+]) in Hypo women...- Acute effects of sodium ingestion on thirst and cardiovascular functionNina S Stachenfeld
The John B Pierce Laboratory and Yale University School of Medicine, New Haven, Connecticut 06519, USA
Curr Sports Med Rep 7:S7-13. 2008.... - Sex hormone effects on body fluid regulationNina S Stachenfeld
The John B Pierce Laboratory and Yale University School of Medicine, New Haven, CT 06519, United States
Exerc Sport Sci Rev 36:152-9. 2008..Although total body water and sodium content are only mildly affected, data presented in this article suggest that reproductive hormones alter homeostatic set points for body fluid and tonicity... 
Exogenous oestradiol and progesterone administration does not cause oedema in healthy young womenNina S Stachenfeld
The John B Pierce Laboratory and Department of Epidemiology and Public Health and Department of Obstetrics and Gynecology and Reproductive Sciences, Yale University School of Medicine, New Haven, CT 06519, USA
Clin Endocrinol (Oxf) 66:410-8. 2007..Thus we hypothesized that oestradiol decreases, while combined oestradiol + progesterone increases, protein and fluid movement out of the vasculature...- Physiological variability of fluid-regulation hormones in young womenN S Stachenfeld
The John B Pierce Laboratory, Yale University School of Medicine, New Haven, Connecticut 06519, USA
J Appl Physiol 86:1092-6. 1999.... - Progesterone increases plasma volume independent of estradiolNina S Stachenfeld
The John B Pierce Laboratory, Yale University School of Medicine, 290 Congress Ave, New Haven, CT 06519, USA
J Appl Physiol 98:1991-7. 2005..This study is the first to isolate P(4) effects on ECF; however, the mechanisms for the ECF and PV expansion have not been clearly defined... - Responses to a saline load in gonadotropin-releasing hormone antagonist-pretreated premenopausal women receiving progesterone or estradiol-progesterone therapyNina S Stachenfeld
John B Pierce Laboratory, Department of Epidemiology, Yale University School of Medicine an Women and Infants Hospital, New Haven, Connecticut 06519, USA
J Clin Endocrinol Metab 90:386-94. 2005..These data suggest that E(2) is the more powerful reproductive hormone involved in sodium retention relative to P(4), and that estrogen-induced up-regulation of P(4) receptors is required for the effects of P(4) on sodium regulation... - Effects of estrogen and progesterone administration on extracellular fluidNina S Stachenfeld
Department of Epidemiology, Yale University School of Medicine, New Haven, CT 06519, USA
J Appl Physiol 96:1011-8. 2004..Thus E(2) increased PV via actions on the capillary endothelium to lower TER(alb) and favor intravascular water retention, whereas during E(2)-P(4) PV increased via the combined responses of ECFV expansion and lower TER(alb)... - Effects of oral contraceptives on body fluid regulationN S Stachenfeld
The John B Pierce Laboratory, Department of Epidemiology and Public Health, and Department of Cellular and Molecular Physiology, Yale University School of Medicine, New Haven, Connecticut 06519, USA
J Appl Physiol 87:1016-25. 1999.... - Estrogen modifies the temperature effects of progesteroneN S Stachenfeld
The John B Pierce Laboratory and Department of Epidemiology and Public Health, Yale University School of Medicine, New Haven, Connecticut 06519, USA
J Appl Physiol 88:1643-9. 2000..These data are also consistent with previous findings that estrogen lowers the thermoregulatory operating point... - Estrogen and progesterone effects on transcapillary fluid dynamicsN S Stachenfeld
The John B Pierce Laboratory and Department of Epidemiology and Public Health, Yale University School of Medicine, New Haven, Connecticut 06519, USA
Am J Physiol Regul Integr Comp Physiol 281:R1319-29. 2001..05), and the PV loss during ANP infusion was attenuated (-0.9 +/- 0.2 and -0.2 +/- 0.2 ml/kg for GnRH analog-alone and E(2)-P(4) treatments, respectively). Thus the E(2)-P(4) treatment lowered CFC and reduced PV loss during ANP infusion... - Sex differences in osmotic regulation of AVP and renal sodium handlingN S Stachenfeld
The John B Pierce Laboratory, Yale University School of Medicine, 290 Congress Ave, New Haven, Connecticut 06519, USA
J Appl Physiol 91:1893-901. 2001..In men, this greater sensitivity was associated with an increase in systolic blood pressure and pulse pressure during HSI, most likely due to a shift in the pressure-natriuresis curve... - Estrogen effects on osmotic regulation of AVP and fluid balanceNina S Stachenfeld
The John B Pierce Laboratory and Departments of Epidemiology and Public Health, Yale University School of Medicine and Women and Infants Hospital, Brown University School of Medicine, New Haven, Connecticut 06519, USA
Am J Physiol Endocrinol Metab 283:E711-21. 2002..Fluid retention increased with both hormone treatments. Renal sensitivity to AVP may be lower during E due to intrarenal effects on water and sodium excretion. E/P increased sodium retention and renin-angiotensin-aldosterone stimulation... - Oestrogen effects on urine concentrating response in young womenNina S Stachenfeld
The John B Pierce Laboratory, New Haven, CT 06519, USA
J Physiol 552:869-80. 2003..However, OE2 may increase renal fluid retention within a physiological range of AVP... - The effects of undergarment composition worn beneath hockey protective equipment on high-intensity intermittent exerciseBenjamin Noonan
Department of Orthopedic Surgery, Yale New Haven Hospital, New Haven, Connecticut, USA
J Strength Cond Res 26:2309-16. 2012..Thermoregulation and performance was driven more by properties of the layered protective equipment with minimal effects from undergarment composition... - Progesterone enhances adrenergic control of skin blood flow in women with high but not low orthostatic toleranceMegan M Wenner
The John B Pierce Laboratory, New Haven, CT, USA
J Physiol 589:975-86. 2011..These data indicate differential regulation of cutaneous adrenergic responses by progesterone via the cyclooxygenase pathway in women with high and low orthostatic tolerance... - The effects of hockey protective equipment on high-intensity intermittent exerciseBenjamin Noonan
Department of Orthopedic Surgery, Yale University School of Medicine, New Haven, CT, USA
Med Sci Sports Exerc 39:1327-35. 2007..We hypothesized that protective equipment would increase core temperature and reduce sprint power after a simulated hockey game... - Sleep, breathing, and menopause: the effect of fluctuating estrogen and progesterone on sleep and breathing in womenNina S Stachenfeld
Division of Pulmonary and Critical Care, Tufts-New England Medical Center, Boston, Massachusetts, USA
Gend Med 2:238-45. 2005..CONCLUSIONS: In this study, sex hormone deficiency in young women resulted in climacteric symptoms and cessation of menses, and was not associated with sleep fragmentation or clinically significant SDB... - American College of Sports Medicine position stand. Exercise and fluid replacementMichael N Sawka
Med Sci Sports Exerc 39:377-90. 2007..After exercise, the goal is to replace any fluid electrolyte deficit. The speed with which rehydration is needed and the magnitude of fluid electrolyte deficits will determine if an aggressive replacement program is merited...
Research Grants
- Estrogen & Progesterone Effects on Orthostatic ToleranceNINA STACHENFELD; Fiscal Year: 2010..We also expect that the data in these studies will provide a basis to study the impact of sex hormones on diseases related to compromised peripheral circulation, such as hypertension, Raynaud's phenomenon and diabetes ..
- Estrogen & Progesterone Effects on Orthostatic ToleranceNINA STACHENFELD; Fiscal Year: 2009..We also expect that the data in these studies will provide a basis to study the impact of sex hormones on diseases related to compromised peripheral circulation, such as hypertension, Raynaud's phenomenon and diabetes ..
- Estrogen & Progesterone Effects on Orthostatic ToleranceNINA STACHENFELD; Fiscal Year: 2007..Project Description Page 6 ..
- Estrogen & Progesterone Effects on Orthostatic ToleranceNINA STACHENFELD; Fiscal Year: 2007..We also expect that the data in these studies will provide a basis to study the impact of sex hormones on diseases related to compromised peripheral circulation, such as hypertension, Raynaud's phenomenon and diabetes ..
- Estrogen & Progesterone Effects on Orthostatic ToleranceNINA STACHENFELD; Fiscal Year: 2005..These studies will define the impact of estrogen and progesterone on the interaction between blood volume and vascular resistance during orthostatic challenges, and thus may improve treatment of orthostatic intolerance in women. ..
- SEX HORMONES AND BODY FLUID REGULATIONNINA STACHENFELD; Fiscal Year: 2003....
- Estrogen & Progesterone Effects on Orthostatic ToleranceNINA STACHENFELD; Fiscal Year: 2010..We also expect that the data in these studies will provide a basis to study the impact of sex hormones on diseases related to compromised peripheral circulation, such as hypertension, Raynaud's phenomenon and diabetes ..