NINA STACHENFELD

Summary

Affiliation: The John B. Pierce Laboratory
Country: USA

Publications

  1. ncbi request reprint The interrelationship of research in the laboratory and the field to assess hydration status and determine mechanisms involved in water regulation during physical activity
    Nina S Stachenfeld
    Departments of Obstetrics, Gynecology and Reproductive Sciences and Epidemiology and Public Health, The John B Pierce Laboratory and Yale School of Medicine, 290 Congress Avenue, New Haven, CT, 06519, USA
    Sports Med 44:97-104. 2014
  2. pmc Blood pressure and water regulation: understanding sex hormone effects within and between men and women
    Megan M Wenner
    The John B Pierce Laboratory, New Haven, CT, USA
    J Physiol 590:5949-61. 2012
  3. pmc Greater exercise sweating in obese women with polycystic ovary syndrome compared with obese controls
    Nina S Stachenfeld
    The John B Pierce Laboratory, 290 Congress Ave, New Haven, CT 06519, USA
    Med Sci Sports Exerc 42:1660-8. 2010
  4. doi request reprint Sex hormone effects on body fluid and sodium regulation in women with and without exercise-associated hyponatremia
    Nina S Stachenfeld
    The John B Pierce Laboratory, Yale University School of Medicine, New Haven, Connecticut 06519, USA
    J Appl Physiol (1985) 107:864-72. 2009
  5. pmc Acute effects of sodium ingestion on thirst and cardiovascular function
    Nina S Stachenfeld
    The John B Pierce Laboratory and Yale University School of Medicine, New Haven, Connecticut 06519, USA
    Curr Sports Med Rep 7:S7-13. 2008
  6. pmc Sex hormone effects on body fluid regulation
    Nina S Stachenfeld
    The John B Pierce Laboratory and Yale University School of Medicine, New Haven, CT 06519, United States
    Exerc Sport Sci Rev 36:152-9. 2008
  7. ncbi request reprint Exogenous oestradiol and progesterone administration does not cause oedema in healthy young women
    Nina S Stachenfeld
    The John B Pierce Laboratory and Department of Epidemiology and Public Health and Department of Obstetrics and Gynecology and Reproductive Sciences, Yale University School of Medicine, New Haven, CT 06519, USA
    Clin Endocrinol (Oxf) 66:410-8. 2007
  8. ncbi request reprint Physiological variability of fluid-regulation hormones in young women
    N S Stachenfeld
    The John B Pierce Laboratory, Yale University School of Medicine, New Haven, Connecticut 06519, USA
    J Appl Physiol (1985) 86:1092-6. 1999
  9. ncbi request reprint Progesterone increases plasma volume independent of estradiol
    Nina S Stachenfeld
    The John B Pierce Laboratory, Yale University School of Medicine, 290 Congress Ave, New Haven, CT 06519, USA
    J Appl Physiol (1985) 98:1991-7. 2005
  10. ncbi request reprint Responses to a saline load in gonadotropin-releasing hormone antagonist-pretreated premenopausal women receiving progesterone or estradiol-progesterone therapy
    Nina S Stachenfeld
    John B Pierce Laboratory, Department of Epidemiology, Yale University School of Medicine an Women and Infants Hospital, New Haven, Connecticut 06519, USA
    J Clin Endocrinol Metab 90:386-94. 2005

Research Grants

  1. SEX HORMONES AND BODY FLUID REGULATION
    NINA STACHENFELD; Fiscal Year: 2000
  2. Estrogen & Progesterone Effects on Orthostatic Tolerance
    NINA STACHENFELD; Fiscal Year: 2010
  3. Estrogen & Progesterone Effects on Orthostatic Tolerance
    NINA STACHENFELD; Fiscal Year: 2009
  4. Estrogen & Progesterone Effects on Orthostatic Tolerance
    NINA STACHENFELD; Fiscal Year: 2007
  5. Estrogen & Progesterone Effects on Orthostatic Tolerance
    NINA STACHENFELD; Fiscal Year: 2007
  6. Estrogen & Progesterone Effects on Orthostatic Tolerance
    NINA STACHENFELD; Fiscal Year: 2005
  7. Estrogen & Progesterone Effects on Orthostatic Tolerance
    NINA STACHENFELD; Fiscal Year: 2004
  8. Estrogen & Progesterone Effects on Orthostatic Tolerance
    NINA STACHENFELD; Fiscal Year: 2003
  9. SEX HORMONES AND BODY FLUID REGULATION
    NINA STACHENFELD; Fiscal Year: 2003
  10. SEX HORMONES AND BODY FLUID REGULATION
    NINA STACHENFELD; Fiscal Year: 2002

Collaborators

Detail Information

Publications22

  1. ncbi request reprint The interrelationship of research in the laboratory and the field to assess hydration status and determine mechanisms involved in water regulation during physical activity
    Nina S Stachenfeld
    Departments of Obstetrics, Gynecology and Reproductive Sciences and Epidemiology and Public Health, The John B Pierce Laboratory and Yale School of Medicine, 290 Congress Avenue, New Haven, CT, 06519, USA
    Sports Med 44:97-104. 2014
    ..There is an important synergy between these two methods of collecting data that support performance and protect athletes from harm during training and improve performance during competition. ..
  2. pmc Blood pressure and water regulation: understanding sex hormone effects within and between men and women
    Megan M Wenner
    The John B Pierce Laboratory, New Haven, CT, USA
    J Physiol 590:5949-61. 2012
    ..Our overarching conclusion is that ovarian hormone exposure is the important underlying factor contributing to differences in blood pressure and water regulation between women and men, and within women throughout the lifespan...
  3. pmc Greater exercise sweating in obese women with polycystic ovary syndrome compared with obese controls
    Nina S Stachenfeld
    The John B Pierce Laboratory, 290 Congress Ave, New Haven, CT 06519, USA
    Med Sci Sports Exerc 42:1660-8. 2010
    ..We hypothesized that core temperature (Tc) threshold for sweating during exercise is delayed in women with PCOS and that testosterone delays the Tc set point for sweating during exercise...
  4. doi request reprint Sex hormone effects on body fluid and sodium regulation in women with and without exercise-associated hyponatremia
    Nina S Stachenfeld
    The John B Pierce Laboratory, Yale University School of Medicine, New Haven, Connecticut 06519, USA
    J Appl Physiol (1985) 107:864-72. 2009
    ..11 (SD 0.11) liter] compared with no Hypo [0.01 (SD 0.15), 0.03 (SD 17), and -0.16 (SD 0.13) liter for GnRH, E2, and E2-P4, P < 0.05] indicates water retention was the primary contributor to the lower S([Na+]) in Hypo women...
  5. pmc Acute effects of sodium ingestion on thirst and cardiovascular function
    Nina S Stachenfeld
    The John B Pierce Laboratory and Yale University School of Medicine, New Haven, Connecticut 06519, USA
    Curr Sports Med Rep 7:S7-13. 2008
    ....
  6. pmc Sex hormone effects on body fluid regulation
    Nina S Stachenfeld
    The John B Pierce Laboratory and Yale University School of Medicine, New Haven, CT 06519, United States
    Exerc Sport Sci Rev 36:152-9. 2008
    ..Although total body water and sodium content are only mildly affected, data presented in this article suggest that reproductive hormones alter homeostatic set points for body fluid and tonicity...
  7. ncbi request reprint Exogenous oestradiol and progesterone administration does not cause oedema in healthy young women
    Nina S Stachenfeld
    The John B Pierce Laboratory and Department of Epidemiology and Public Health and Department of Obstetrics and Gynecology and Reproductive Sciences, Yale University School of Medicine, New Haven, CT 06519, USA
    Clin Endocrinol (Oxf) 66:410-8. 2007
    ..Thus we hypothesized that oestradiol decreases, while combined oestradiol + progesterone increases, protein and fluid movement out of the vasculature...
  8. ncbi request reprint Physiological variability of fluid-regulation hormones in young women
    N S Stachenfeld
    The John B Pierce Laboratory, Yale University School of Medicine, New Haven, Connecticut 06519, USA
    J Appl Physiol (1985) 86:1092-6. 1999
    ....
  9. ncbi request reprint Progesterone increases plasma volume independent of estradiol
    Nina S Stachenfeld
    The John B Pierce Laboratory, Yale University School of Medicine, 290 Congress Ave, New Haven, CT 06519, USA
    J Appl Physiol (1985) 98:1991-7. 2005
    ..This study is the first to isolate P(4) effects on ECF; however, the mechanisms for the ECF and PV expansion have not been clearly defined...
  10. ncbi request reprint Responses to a saline load in gonadotropin-releasing hormone antagonist-pretreated premenopausal women receiving progesterone or estradiol-progesterone therapy
    Nina S Stachenfeld
    John B Pierce Laboratory, Department of Epidemiology, Yale University School of Medicine an Women and Infants Hospital, New Haven, Connecticut 06519, USA
    J Clin Endocrinol Metab 90:386-94. 2005
    ..These data suggest that E(2) is the more powerful reproductive hormone involved in sodium retention relative to P(4), and that estrogen-induced up-regulation of P(4) receptors is required for the effects of P(4) on sodium regulation...
  11. ncbi request reprint Effects of oral contraceptives on body fluid regulation
    N S Stachenfeld
    The John B Pierce Laboratory, Department of Epidemiology and Public Health, and Department of Cellular and Molecular Physiology, Yale University School of Medicine, New Haven, Connecticut 06519, USA
    J Appl Physiol (1985) 87:1016-25. 1999
    ....
  12. ncbi request reprint Estrogen modifies the temperature effects of progesterone
    N S Stachenfeld
    The John B Pierce Laboratory and Department of Epidemiology and Public Health, Yale University School of Medicine, New Haven, Connecticut 06519, USA
    J Appl Physiol (1985) 88:1643-9. 2000
    ..These data are also consistent with previous findings that estrogen lowers the thermoregulatory operating point...
  13. ncbi request reprint Estrogen and progesterone effects on transcapillary fluid dynamics
    N S Stachenfeld
    The John B Pierce Laboratory and Department of Epidemiology and Public Health, Yale University School of Medicine, New Haven, Connecticut 06519, USA
    Am J Physiol Regul Integr Comp Physiol 281:R1319-29. 2001
    ..05), and the PV loss during ANP infusion was attenuated (-0.9 +/- 0.2 and -0.2 +/- 0.2 ml/kg for GnRH analog-alone and E(2)-P(4) treatments, respectively). Thus the E(2)-P(4) treatment lowered CFC and reduced PV loss during ANP infusion...
  14. ncbi request reprint Sex differences in osmotic regulation of AVP and renal sodium handling
    N S Stachenfeld
    The John B Pierce Laboratory, Yale University School of Medicine, 290 Congress Ave, New Haven, Connecticut 06519, USA
    J Appl Physiol (1985) 91:1893-901. 2001
    ..In men, this greater sensitivity was associated with an increase in systolic blood pressure and pulse pressure during HSI, most likely due to a shift in the pressure-natriuresis curve...
  15. ncbi request reprint Estrogen effects on osmotic regulation of AVP and fluid balance
    Nina S Stachenfeld
    The John B Pierce Laboratory and Departments of Epidemiology and Public Health, Yale University School of Medicine and Women and Infants Hospital, Brown University School of Medicine, New Haven, Connecticut 06519, USA
    Am J Physiol Endocrinol Metab 283:E711-21. 2002
    ..Fluid retention increased with both hormone treatments. Renal sensitivity to AVP may be lower during E due to intrarenal effects on water and sodium excretion. E/P increased sodium retention and renin-angiotensin-aldosterone stimulation...
  16. pmc Oestrogen effects on urine concentrating response in young women
    Nina S Stachenfeld
    The John B Pierce Laboratory, New Haven, CT 06519, USA
    J Physiol 552:869-80. 2003
    ..However, OE2 may increase renal fluid retention within a physiological range of AVP...
  17. ncbi request reprint Effects of estrogen and progesterone administration on extracellular fluid
    Nina S Stachenfeld
    Department of Epidemiology, Yale University School of Medicine, New Haven, CT 06519, USA
    J Appl Physiol (1985) 96:1011-8. 2004
    ..Thus E(2) increased PV via actions on the capillary endothelium to lower TER(alb) and favor intravascular water retention, whereas during E(2)-P(4) PV increased via the combined responses of ECFV expansion and lower TER(alb)...
  18. doi request reprint The effects of undergarment composition worn beneath hockey protective equipment on high-intensity intermittent exercise
    Benjamin Noonan
    Department of Orthopedic Surgery, Yale New Haven Hospital, New Haven, Connecticut, USA
    J Strength Cond Res 26:2309-16. 2012
    ..Thermoregulation and performance was driven more by properties of the layered protective equipment with minimal effects from undergarment composition...
  19. pmc Progesterone enhances adrenergic control of skin blood flow in women with high but not low orthostatic tolerance
    Megan M Wenner
    The John B Pierce Laboratory, New Haven, CT, USA
    J Physiol 589:975-86. 2011
    ..These data indicate differential regulation of cutaneous adrenergic responses by progesterone via the cyclooxygenase pathway in women with high and low orthostatic tolerance...
  20. ncbi request reprint The effects of hockey protective equipment on high-intensity intermittent exercise
    Benjamin Noonan
    Department of Orthopedic Surgery, Yale University School of Medicine, New Haven, CT, USA
    Med Sci Sports Exerc 39:1327-35. 2007
    ..We hypothesized that protective equipment would increase core temperature and reduce sprint power after a simulated hockey game...
  21. ncbi request reprint Sleep, breathing, and menopause: the effect of fluctuating estrogen and progesterone on sleep and breathing in women
    Carolyn D'Ambrosio
    Division of Pulmonary and Critical Care, Tufts New England Medical Center, Boston, Massachusetts, USA
    Gend Med 2:238-45. 2005
    ..However, menopause increases the risk for development of OSA. Administration of estrogen and progesterone to postmenopausal women with OSA decreases apnea and hypopnea during sleep...
  22. ncbi request reprint American College of Sports Medicine position stand. Exercise and fluid replacement
    Michael N Sawka
    Med Sci Sports Exerc 39:377-90. 2007
    ..After exercise, the goal is to replace any fluid electrolyte deficit. The speed with which rehydration is needed and the magnitude of fluid electrolyte deficits will determine if an aggressive replacement program is merited...

Research Grants13

  1. SEX HORMONES AND BODY FLUID REGULATION
    NINA STACHENFELD; Fiscal Year: 2000
    ....
  2. Estrogen & Progesterone Effects on Orthostatic Tolerance
    NINA STACHENFELD; Fiscal Year: 2010
    ..We also expect that the data in these studies will provide a basis to study the impact of sex hormones on diseases related to compromised peripheral circulation, such as hypertension, Raynaud's phenomenon and diabetes ..
  3. Estrogen & Progesterone Effects on Orthostatic Tolerance
    NINA STACHENFELD; Fiscal Year: 2009
    ..We also expect that the data in these studies will provide a basis to study the impact of sex hormones on diseases related to compromised peripheral circulation, such as hypertension, Raynaud's phenomenon and diabetes ..
  4. Estrogen & Progesterone Effects on Orthostatic Tolerance
    NINA STACHENFELD; Fiscal Year: 2007
    ..Project Description Page 6 ..
  5. Estrogen & Progesterone Effects on Orthostatic Tolerance
    NINA STACHENFELD; Fiscal Year: 2007
    ..We also expect that the data in these studies will provide a basis to study the impact of sex hormones on diseases related to compromised peripheral circulation, such as hypertension, Raynaud's phenomenon and diabetes ..
  6. Estrogen & Progesterone Effects on Orthostatic Tolerance
    NINA STACHENFELD; Fiscal Year: 2005
    ..These studies will define the impact of estrogen and progesterone on the interaction between blood volume and vascular resistance during orthostatic challenges, and thus may improve treatment of orthostatic intolerance in women. ..
  7. Estrogen & Progesterone Effects on Orthostatic Tolerance
    NINA STACHENFELD; Fiscal Year: 2004
    ..These studies will define the impact of estrogen and progesterone on the interaction between blood volume and vascular resistance during orthostatic challenges, and thus may improve treatment of orthostatic intolerance in women. ..
  8. Estrogen & Progesterone Effects on Orthostatic Tolerance
    NINA STACHENFELD; Fiscal Year: 2003
    ..These studies will define the impact of estrogen and progesterone on the interaction between blood volume and vascular resistance during orthostatic challenges, and thus may improve treatment of orthostatic intolerance in women. ..
  9. SEX HORMONES AND BODY FLUID REGULATION
    NINA STACHENFELD; Fiscal Year: 2003
    ....
  10. SEX HORMONES AND BODY FLUID REGULATION
    NINA STACHENFELD; Fiscal Year: 2002
    ....
  11. SEX HORMONES AND BODY FLUID REGULATION
    NINA STACHENFELD; Fiscal Year: 2001
    ....
  12. Estrogen & Progesterone Effects on Orthostatic Tolerance
    NINA STACHENFELD; Fiscal Year: 2010
    ..We also expect that the data in these studies will provide a basis to study the impact of sex hormones on diseases related to compromised peripheral circulation, such as hypertension, Raynaud's phenomenon and diabetes ..