Stanley J Stachelek

Summary

Affiliation: The Children's Hospital of Philadelphia
Country: USA

Publications

  1. ncbi request reprint Biological stability of polyurethane modified with covalent attachment of di-tert-butyl-phenol
    Stanley J Stachelek
    Division of Cardiology, The Children s Hospital of Philadelphia, 3615 Civic Center Blvd, Abramson Research Bldg, Suite 702, Philadelphia, Pennsylvania 19104 4318, USA
    J Biomed Mater Res A 82:1004-11. 2007
  2. pmc Prevention of polyurethane oxidative degradation with phenolic antioxidants covalently attached to the hard segments: structure-function relationships
    Stanley J Stachelek
    Department of Pediatrics, The Children s Hospital of Philadelphia, Philadelphia, Pennsylvania 19104, USA
    J Biomed Mater Res A 94:751-9. 2010
  3. pmc The effect of CD47 modified polymer surfaces on inflammatory cell attachment and activation
    Stanley J Stachelek
    Division of Cardiology, Department of Pediatrics, The Children s Hospital of Philadelphia, PA, USA
    Biomaterials 32:4317-26. 2011
  4. ncbi request reprint Cholesterol-modified polyurethane valve cusps demonstrate blood outgrowth endothelial cell adhesion post-seeding in vitro and in vivo
    Stanley J Stachelek
    Department of Pediatrics, The Children s Hospital of Philadelphia, Pennsylvania 19104 4318, USA
    Ann Thorac Surg 81:47-55. 2006
  5. pmc CD47-dependent molecular mechanisms of blood outgrowth endothelial cell attachment on cholesterol-modified polyurethane
    Masako Ueda
    Division of Cardiology, Department of Pediatrics, The Children s Hospital of Philadelphia, Philadelphia, PA 19104 4318, USA
    Biomaterials 31:6394-9. 2010
  6. pmc Correlating macrophage morphology and cytokine production resulting from biomaterial contact
    Hyun Su Lee
    Department of Anesthesiology and Critical Care, University of Pennsylvania, Philadelphia, Pennsylvania 19104 6802, USA
    J Biomed Mater Res A 101:203-12. 2013
  7. pmc Diminished adhesion and activation of platelets and neutrophils with CD47 functionalized blood contacting surfaces
    Matthew J Finley
    Division of Cardiology, Department of Pediatrics, The Children s Hospital of Philadelphia, PA 19104 4318, USA
    Biomaterials 33:5803-11. 2012
  8. ncbi request reprint Surface heparinization of polyurethane via bromoalkylation of hard segment nitrogens
    Ivan S Alferiev
    Children s Hospital of Philadelphia, Divisions of Cardiology and Hematology, Abramson Research Center, Suite 702, 3516 Civic Center Blvd, Philadelphia, PA 19104 4318, USA
    Biomacromolecules 7:317-22. 2006
  9. ncbi request reprint Prevention of oxidative degradation of polyurethane by covalent attachment of di-tert-butylphenol residues
    Stanley J Stachelek
    Division of Cardiology, The Children s Hospital of Philadelphia, Philadelphia, Pennsylvania 19104 4318, USA
    J Biomed Mater Res A 78:653-61. 2006
  10. doi request reprint Micropatterning of three-dimensional electrospun polyurethane vascular grafts
    Pimpon Uttayarat
    School of Biomedical Engineering, Science and Health Systems, Drexel University, Philadelphia, PA 19104, USA
    Acta Biomater 6:4229-37. 2010

Collaborators

  • Ivan S Alferiev
  • Jeanne M Connolly
  • Russell J Composto
  • Lubica Rauova
  • Matthew J Finley
  • Robert J Levy
  • Hyun Su Lee
  • Masako Ueda
  • Pimpon Uttayarat
  • Ilia Fishbein
  • Katherine A Clark
  • Nancy Tomczyk
  • David M Eckmann
  • John W Weisel
  • Peter I Lelkes
  • Stacey B Simons
  • Anat Perets
  • Pimchanok Pimton
  • Robert P Hebbel
  • Mengyan Li
  • Peter Sobolewski
  • Meizan Lai
  • Marina Bakay
  • Hoon Choi
  • I W Chen

Detail Information

Publications14

  1. ncbi request reprint Biological stability of polyurethane modified with covalent attachment of di-tert-butyl-phenol
    Stanley J Stachelek
    Division of Cardiology, The Children s Hospital of Philadelphia, 3615 Civic Center Blvd, Abramson Research Bldg, Suite 702, Philadelphia, Pennsylvania 19104 4318, USA
    J Biomed Mater Res A 82:1004-11. 2007
    ....
  2. pmc Prevention of polyurethane oxidative degradation with phenolic antioxidants covalently attached to the hard segments: structure-function relationships
    Stanley J Stachelek
    Department of Pediatrics, The Children s Hospital of Philadelphia, Philadelphia, Pennsylvania 19104, USA
    J Biomed Mater Res A 94:751-9. 2010
    ..These data show for the first time that the choice of linker molecule significantly affects the efficiency of the linked phenolic antioxidant...
  3. pmc The effect of CD47 modified polymer surfaces on inflammatory cell attachment and activation
    Stanley J Stachelek
    Division of Cardiology, Department of Pediatrics, The Children s Hospital of Philadelphia, PA, USA
    Biomaterials 32:4317-26. 2011
    ..In conclusion, CD47 functionalized surfaces can resist inflammatory cell interactions both in vitro and in vivo...
  4. ncbi request reprint Cholesterol-modified polyurethane valve cusps demonstrate blood outgrowth endothelial cell adhesion post-seeding in vitro and in vivo
    Stanley J Stachelek
    Department of Pediatrics, The Children s Hospital of Philadelphia, Pennsylvania 19104 4318, USA
    Ann Thorac Surg 81:47-55. 2006
    ....
  5. pmc CD47-dependent molecular mechanisms of blood outgrowth endothelial cell attachment on cholesterol-modified polyurethane
    Masako Ueda
    Division of Cardiology, Department of Pediatrics, The Children s Hospital of Philadelphia, Philadelphia, PA 19104 4318, USA
    Biomaterials 31:6394-9. 2010
    ..These data are the first demonstration of a role for the CD47 cholesterol-dependent signaling complex in BOEC attachment onto synthetic surfaces...
  6. pmc Correlating macrophage morphology and cytokine production resulting from biomaterial contact
    Hyun Su Lee
    Department of Anesthesiology and Critical Care, University of Pennsylvania, Philadelphia, Pennsylvania 19104 6802, USA
    J Biomed Mater Res A 101:203-12. 2013
    ..These studies begin to validate the use of GFP-actin-modified MDM as a novel tool to correlate cell morphology with inflammatory cell response...
  7. pmc Diminished adhesion and activation of platelets and neutrophils with CD47 functionalized blood contacting surfaces
    Matthew J Finley
    Division of Cardiology, Department of Pediatrics, The Children s Hospital of Philadelphia, PA 19104 4318, USA
    Biomaterials 33:5803-11. 2012
    ..In addition, ethylene oxide gas sterilization did not inhibit the efficacy of the CD47 modification. In conclusion, CD47 modified PVC inhibits both the adhesion and activation of platelets and neutrophils...
  8. ncbi request reprint Surface heparinization of polyurethane via bromoalkylation of hard segment nitrogens
    Ivan S Alferiev
    Children s Hospital of Philadelphia, Divisions of Cardiology and Hematology, Abramson Research Center, Suite 702, 3516 Civic Center Blvd, Philadelphia, PA 19104 4318, USA
    Biomacromolecules 7:317-22. 2006
    ....
  9. ncbi request reprint Prevention of oxidative degradation of polyurethane by covalent attachment of di-tert-butylphenol residues
    Stanley J Stachelek
    Division of Cardiology, The Children s Hospital of Philadelphia, Philadelphia, Pennsylvania 19104 4318, USA
    J Biomed Mater Res A 78:653-61. 2006
    ..In conclusion, these results demonstrate that derivatizing PU with DBP confers significant resistance to oxidative degradation compared with unmodified PU...
  10. doi request reprint Micropatterning of three-dimensional electrospun polyurethane vascular grafts
    Pimpon Uttayarat
    School of Biomedical Engineering, Science and Health Systems, Drexel University, Philadelphia, PA 19104, USA
    Acta Biomater 6:4229-37. 2010
    ....
  11. ncbi request reprint Cholesterol-derivatized polyurethane: characterization and endothelial cell adhesion
    Stanley J Stachelek
    Division of Cardiology, The Children s Hospital of Philadelphia, Philadelphia, Pennsylvania 19104 4318, USA
    J Biomed Mater Res A 72:200-12. 2005
    ..56 +/- 0.85% (p < 0.001). It is concluded that covalently linking cholesterol to polyurethane results in improved material properties that permit increased endothelial cell retention compared with unmodified polyurethane...
  12. pmc Intracellular signaling mechanisms associated with CD47 modified surfaces
    Matthew J Finley
    Division of Cardiology, Department of Pediatrics, The Children s Hospital of Philadelphia, Philadelphia, PA, USA
    Biomaterials 34:8640-9. 2013
    ..Our data demonstrate that differential molecular responses to CD47 involve downregulation of cytokines, upregulation of MMPs, and JAK/STAT signaling mechanisms. ..
  13. ncbi request reprint Prevention of polyurethane valve cusp calcification with covalently attached bisphosphonate diethylamino moieties
    Ivan Alferiev
    Division of Cardiology, The Children s Hospital of Philadelphia, Abramson Research Bldg, 3516 Civic Center Blvd, Philadelphia, Pennsylvania 19104 4318, USA
    J Biomed Mater Res A 66:385-95. 2003
    ..Thus we evaluated the mechanical and in vivo anticalcification properties of heart-valve leaflets composed of this modified polymer...
  14. pmc Local delivery of gene vectors from bare-metal stents by use of a biodegradable synthetic complex inhibits in-stent restenosis in rat carotid arteries
    Ilia Fishbein
    Division of Cardiology, Children s Hospital of Philadelphia, Philadelphia, PA 19104, USA
    Circulation 117:2096-103. 2008
    ..Thus, we investigated the hypothesis that adenoviral vectors (Ad) could be delivered from the bare-metal surfaces of stents with a synthetic complex for reversible vector binding...