Geetha Srikrishna

Summary

Affiliation: The Burnham Institute
Country: USA

Publications

  1. ncbi request reprint Molecular cloning, gene organization, and expression of mouse Mpi encoding phosphomannose isomerase
    Joseph A Davis
    Glycobiology Program, The Burnham Institute, 10901 North Torrey Pines Rd, La Jolla, CA 92037, USA
    Glycobiology 12:435-42. 2002
  2. ncbi request reprint Carboxylated glycans mediate colitis through activation of NF-kappa B
    Geetha Srikrishna
    Glycobiology Program, The Burnham Institute, La Jolla, CA 92037, USA
    J Immunol 175:5412-22. 2005
  3. pmc Endogenous damage-associated molecular pattern molecules at the crossroads of inflammation and cancer
    Geetha Srikrishna
    Tumor Microenvironment Program, Cancer Center, The Burnham Institute for Medical Research, La Jolla, CA 92037, USA
    Neoplasia 11:615-28. 2009
  4. pmc Carboxylated N-glycans on RAGE promote S100A12 binding and signaling
    Geetha Srikrishna
    Sanford Children s Health Research Center, Sanford Burnham Medical Research Institute, La Jolla, California 92037, USA
    J Cell Biochem 110:645-59. 2010
  5. pmc S100A8/A9 activate key genes and pathways in colon tumor progression
    Mie Ichikawa
    Sanford Children s Health Research Center, Sanford Burnham Medical Research Institute, 10905 Road to the Cure, San Diego, CA 92121, USA
    Mol Cancer Res 9:133-48. 2011
  6. pmc RAGE, carboxylated glycans and S100A8/A9 play essential roles in colitis-associated carcinogenesis
    Olga Turovskaya
    Division of Developmental Immunology, La Jolla Institute for Allergy and Immunology, La Jolla, CA, USA
    Carcinogenesis 29:2035-43. 2008
  7. pmc S100A8 and S100A9: new insights into their roles in malignancy
    Geetha Srikrishna
    Sanford Children s Health Research Center, Sanford Burnham Medical Research Institute, La Jolla, CA, USA
    J Innate Immun 4:31-40. 2012
  8. ncbi request reprint N -Glycans on the receptor for advanced glycation end products influence amphoterin binding and neurite outgrowth
    Geetha Srikrishna
    The Burnham Institute, La Jolla, California 92037, USA
    J Neurochem 80:998-1008. 2002
  9. ncbi request reprint Novel carboxylated N-glycans contain oligosaccharide-linked glutamic acid
    Geetha Srikrishna
    Glycobiology Program, The Burnham Institute, La Jolla, CA, USA
    Biochem Biophys Res Commun 332:1020-7. 2005

Collaborators

Detail Information

Publications9

  1. ncbi request reprint Molecular cloning, gene organization, and expression of mouse Mpi encoding phosphomannose isomerase
    Joseph A Davis
    Glycobiology Program, The Burnham Institute, 10901 North Torrey Pines Rd, La Jolla, CA 92037, USA
    Glycobiology 12:435-42. 2002
    ....
  2. ncbi request reprint Carboxylated glycans mediate colitis through activation of NF-kappa B
    Geetha Srikrishna
    Glycobiology Program, The Burnham Institute, La Jolla, CA 92037, USA
    J Immunol 175:5412-22. 2005
    ..It specifically blocked activation of NF-kappaB p65 in lamina propria cells of colitic mice and in activated macrophages. These results indicate that carboxylate-glycan-dependent pathways contribute to the early onset of colitis...
  3. pmc Endogenous damage-associated molecular pattern molecules at the crossroads of inflammation and cancer
    Geetha Srikrishna
    Tumor Microenvironment Program, Cancer Center, The Burnham Institute for Medical Research, La Jolla, CA 92037, USA
    Neoplasia 11:615-28. 2009
    ..This review focuses on the role of DAMP molecules high-mobility group box 1 and S100 proteins in inflammation, tumor growth, and early metastatic events...
  4. pmc Carboxylated N-glycans on RAGE promote S100A12 binding and signaling
    Geetha Srikrishna
    Sanford Children s Health Research Center, Sanford Burnham Medical Research Institute, La Jolla, California 92037, USA
    J Cell Biochem 110:645-59. 2010
    ..These results demonstrate that carboxylated N-glycans on RAGE enhance binding potential and promote receptor clustering and subsequent signaling events following oligomeric S100A12 binding...
  5. pmc S100A8/A9 activate key genes and pathways in colon tumor progression
    Mie Ichikawa
    Sanford Children s Health Research Center, Sanford Burnham Medical Research Institute, 10905 Road to the Cure, San Diego, CA 92121, USA
    Mol Cancer Res 9:133-48. 2011
    ..Our results thus reveal a novel role for myeloid-derived S100A8/A9 in activating specific downstream genes associated with tumorigenesis and in promoting tumor growth and metastasis...
  6. pmc RAGE, carboxylated glycans and S100A8/A9 play essential roles in colitis-associated carcinogenesis
    Olga Turovskaya
    Division of Developmental Immunology, La Jolla Institute for Allergy and Immunology, La Jolla, CA, USA
    Carcinogenesis 29:2035-43. 2008
    ..These findings show that RAGE, carboxylated glycans and S100A8/A9 play essential roles in tumor-stromal interactions, leading to inflammation-associated colon carcinogenesis...
  7. pmc S100A8 and S100A9: new insights into their roles in malignancy
    Geetha Srikrishna
    Sanford Children s Health Research Center, Sanford Burnham Medical Research Institute, La Jolla, CA, USA
    J Innate Immun 4:31-40. 2012
    ..Elucidating molecular pathways mediated by these proteins promises to provide potential novel targets for the development of cancer therapeutics and to establish valid biomarkers to identify early stages of tumor progression...
  8. ncbi request reprint N -Glycans on the receptor for advanced glycation end products influence amphoterin binding and neurite outgrowth
    Geetha Srikrishna
    The Burnham Institute, La Jolla, California 92037, USA
    J Neurochem 80:998-1008. 2002
    ..These results indicate that carboxylated N -glycans on RAGE play an important functional role in amphoterin-RAGE-mediated signalling...
  9. ncbi request reprint Novel carboxylated N-glycans contain oligosaccharide-linked glutamic acid
    Geetha Srikrishna
    Glycobiology Program, The Burnham Institute, La Jolla, CA, USA
    Biochem Biophys Res Commun 332:1020-7. 2005
    ..These results demonstrate that mammalian cells synthesize complex-type N-glycans with glutamate linked to their antennae, further expanding their potential for covalent or ionic interactions...