Margaret Spitz

Summary

Affiliation: The University of Texas
Country: USA

Publications

  1. ncbi Epidemiology--found in translation
    Margaret R Spitz
    The University of Texas MD Anderson Cancer Center, Box 1340, 1155 Pressler, Houston, TX 77030, USA
    Cancer Discov 1:21-2. 2011
  2. pmc Correlates of susceptibility to smoking among Mexican origin youth residing in Houston, Texas: a cross-sectional analysis
    Anna V Wilkinson
    Department of Epidemiology, Unit 1340, The University of Texas M D Anderson Cancer Center, PO Box 301439, Houston, TX 77230 1439, USA
    BMC Public Health 8:337. 2008
  3. pmc Rapid method for determination of DNA repair capacity in human peripheral blood lymphocytes amongst smokers
    Randa A El-Zein
    Department of Epidemiology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA
    BMC Cancer 10:439. 2010
  4. ncbi Serum insulin-like growth factor (IGF) and IGF-binding protein levels and risk of lung cancer: a case-control study nested in the beta-Carotene and Retinol Efficacy Trial Cohort
    Margaret R Spitz
    Department of Epidemiology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Cancer Epidemiol Biomarkers Prev 11:1413-8. 2002
  5. pmc An expanded risk prediction model for lung cancer
    Margaret R Spitz
    Department of Epidemiology, Unit 1340, The University of Texas M D Anderson Cancer Center, P O Box 301439, Houston, TX 77230 1439, USA
    Cancer Prev Res (Phila) 1:250-4. 2008
  6. ncbi Integrative epidemiology: from risk assessment to outcome prediction
    Margaret R Spitz
    Department of Epidemiology, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Blvd, Box 189, Houston, TX 77030, USA
    J Clin Oncol 23:267-75. 2005
  7. ncbi Genetic susceptibility to lung cancer: the role of DNA damage and repair
    Margaret R Spitz
    Department of Epidemiology, The University of Texas, M D Anderson Cancer Center, Houston, Texas 77030, USA
    Cancer Epidemiol Biomarkers Prev 12:689-98. 2003
  8. ncbi Epidemiologic determinants of clinically relevant prostate cancer
    M R Spitz
    Department of Epidemiology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Int J Cancer 89:259-64. 2000
  9. pmc The CHRNA5-A3 region on chromosome 15q24-25.1 is a risk factor both for nicotine dependence and for lung cancer
    Margaret R Spitz
    Department of Epidemiology, The University of Texas MD Anderson Cancer Center, Houston, TX 77230 1439, USA
    J Natl Cancer Inst 100:1552-6. 2008
  10. pmc The evolving discipline of molecular epidemiology of cancer
    Margaret R Spitz
    Department of Epidemiology, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Carcinogenesis 31:127-34. 2010

Collaborators

Detail Information

Publications87

  1. ncbi Epidemiology--found in translation
    Margaret R Spitz
    The University of Texas MD Anderson Cancer Center, Box 1340, 1155 Pressler, Houston, TX 77030, USA
    Cancer Discov 1:21-2. 2011
    ..Coupling epidemiologic data with an in vitro screen of commonly used therapeutic agents may identify novel applications for further clinical testing...
  2. pmc Correlates of susceptibility to smoking among Mexican origin youth residing in Houston, Texas: a cross-sectional analysis
    Anna V Wilkinson
    Department of Epidemiology, Unit 1340, The University of Texas M D Anderson Cancer Center, PO Box 301439, Houston, TX 77230 1439, USA
    BMC Public Health 8:337. 2008
    ..In this analysis we examined the relationship between susceptibility to smoking and well-known risk factors associated with smoking initiation among a cohort of 11 to 13 year old Mexican origin youth residing in Houston, Texas...
  3. pmc Rapid method for determination of DNA repair capacity in human peripheral blood lymphocytes amongst smokers
    Randa A El-Zein
    Department of Epidemiology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA
    BMC Cancer 10:439. 2010
    ..It has been previously reported that smokers with low hOGG1 activity had significantly higher risk of developing lung cancer as compared to smokers with high hOGG1 activity...
  4. ncbi Serum insulin-like growth factor (IGF) and IGF-binding protein levels and risk of lung cancer: a case-control study nested in the beta-Carotene and Retinol Efficacy Trial Cohort
    Margaret R Spitz
    Department of Epidemiology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Cancer Epidemiol Biomarkers Prev 11:1413-8. 2002
    ..Finally, from these data, we cannot exclude the possibility that risk of lung cancer in nonsmokers may be related to IGF-I levels...
  5. pmc An expanded risk prediction model for lung cancer
    Margaret R Spitz
    Department of Epidemiology, Unit 1340, The University of Texas M D Anderson Cancer Center, P O Box 301439, Houston, TX 77230 1439, USA
    Cancer Prev Res (Phila) 1:250-4. 2008
    ..Addition of biomarker assays improved the sensitivity of the expanded models...
  6. ncbi Integrative epidemiology: from risk assessment to outcome prediction
    Margaret R Spitz
    Department of Epidemiology, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Blvd, Box 189, Houston, TX 77030, USA
    J Clin Oncol 23:267-75. 2005
    ..We will provide examples of how changes in the function of a single gene can contribute to susceptibility to carcinogenic exposure, predisposition to cancer development, patient prognosis, and prediction of outcome...
  7. ncbi Genetic susceptibility to lung cancer: the role of DNA damage and repair
    Margaret R Spitz
    Department of Epidemiology, The University of Texas, M D Anderson Cancer Center, Houston, Texas 77030, USA
    Cancer Epidemiol Biomarkers Prev 12:689-98. 2003
  8. ncbi Epidemiologic determinants of clinically relevant prostate cancer
    M R Spitz
    Department of Epidemiology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Int J Cancer 89:259-64. 2000
    ..Weight gain in early adulthood and smoking thus appear to be important predictors of virulent prostate cancer. Our data also suggest that prior screening is associated with diagnosis of lower-volume and lower-score disease...
  9. pmc The CHRNA5-A3 region on chromosome 15q24-25.1 is a risk factor both for nicotine dependence and for lung cancer
    Margaret R Spitz
    Department of Epidemiology, The University of Texas MD Anderson Cancer Center, Houston, TX 77230 1439, USA
    J Natl Cancer Inst 100:1552-6. 2008
    ..Thus, we conclude that the variants are implicated both in smoking behavior and more directly in lung cancer risk...
  10. pmc The evolving discipline of molecular epidemiology of cancer
    Margaret R Spitz
    Department of Epidemiology, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Carcinogenesis 31:127-34. 2010
    ..However, there will always be the need for impeccably designed and well-powered epidemiologic studies with rigorous quality control of data, specimen acquisition and statistical analysis...
  11. ncbi Modulation of nucleotide excision repair capacity by XPD polymorphisms in lung cancer patients
    M R Spitz
    Department of Epidemiology, The University of Texas M D Anderson Cancer Center, Houston 77030, USA
    Cancer Res 61:1354-7. 2001
    ..These results suggest that the two XPD polymorphisms have a modulating effect on DRC, especially in the cases...
  12. ncbi Dietary intake of isothiocyanates: evidence of a joint effect with glutathione S-transferase polymorphisms in lung cancer risk
    M R Spitz
    Department of Epidemiology The University of Texas M D Anderson Cancer Center, Houston 77030, USA
    Cancer Epidemiol Biomarkers Prev 9:1017-20. 2000
    ..Some of the inconsistencies reported in the role of GST genotypes in lung cancer risk could be due to unexpected confounding from dietary factors...
  13. ncbi A risk model for prediction of lung cancer
    Margaret R Spitz
    Department of Epidemiology Unit 1340, The University of Texas M D Anderson Cancer Center, PO Box 301439, Houston, TX 77230 1439, USA
    J Natl Cancer Inst 99:715-26. 2007
    ..Reliable risk prediction tools for estimating individual probability of lung cancer have important public health implications. We constructed and validated a comprehensive clinical tool for lung cancer risk prediction by smoking status...
  14. ncbi Modulation of repair of ultraviolet damage in the host-cell reactivation assay by polymorphic XPC and XPD/ERCC2 genotypes
    Yawei Qiao
    Department of Epidemiology, The University of Texas M D Anderson Cancer Center, Houston, 1515 Holcombe Boulevard, TX 77030, USA
    Carcinogenesis 23:295-9. 2002
    ..We concluded that these NER polymorphisms may modulate DRC and may be useful biomarkers for identifying individuals at risk of developing cancer...
  15. ncbi Evaluation of glutathione S-transferase polymorphisms and mutagen sensitivity as risk factors for the development of second primary tumors in patients previously diagnosed with early-stage head and neck cancer
    Charles G Minard
    Department of Epidemiology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Cancer 106:2636-44. 2006
    ..Data were available for 303 patients who were enrolled in a placebo-controlled chemoprevention trial of low-dose 13-cis-retinoic acid to reduce the occurrence of SPTs...
  16. ncbi Genetic polymorphisms in DNA base-excision repair genes ADPRT, XRCC1, and APE1 and the risk of squamous cell carcinoma of the head and neck
    Chunying Li
    Department of Epidemiology, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Cancer 110:867-75. 2007
    ....
  17. pmc Genetic variations in interleukin-8 and interleukin-10 are associated with pain, depressed mood, and fatigue in lung cancer patients
    Cielito C Reyes-Gibby
    Department of Emergency Medicine, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    J Pain Symptom Manage 46:161-72. 2013
    ..A report by the National Cancer Institute identified that an important gap in symptom research is the investigation of multiple symptoms of cancer that might identify common biological mechanisms among cancer-related symptoms...
  18. ncbi Nucleotide excision repair pathway genes and oral premalignant lesions
    Yunfei Wang
    Department of Epidemiology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Clin Cancer Res 13:3753-8. 2007
    ..Polymorphisms in NER genes may cause variations in DNA repair capacity and increase susceptibility to both premalignant lesions and cancer...
  19. ncbi Polymorphisms of vitamin D receptor gene protect against the risk of head and neck cancer
    Zhensheng Liu
    Department of Epidemiology, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA
    Pharmacogenet Genomics 15:159-65. 2005
    ..001). These data suggest that the VDR f and t alleles and their genotypes may protect against SCCHN. However, further studies are warranted to confirm these findings...
  20. ncbi Haplotypes of two variants in p16 (CDKN2/MTS-1/INK4a) exon 3 and risk of squamous cell carcinoma of the head and neck: a case-control study
    Yuxin Zheng
    Department of Epidemiology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Cancer Epidemiol Biomarkers Prev 11:640-5. 2002
    ..We conclude that these polymorphic p16 genotypes or haplotypes may not play a major role in the etiology of SCCHN, if any. However, our limited sample size and power call for larger studies for additional verification of our findings...
  21. ncbi Combined effects of the p53 and p73 polymorphisms on lung cancer risk
    Matthew B Schabath
    Department of Epidemiology, The University of Texas M D Anderson Cancer Center, Houston, TX 77230 1439, USA
    Cancer Epidemiol Biomarkers Prev 15:158-61. 2006
    ....
  22. ncbi Potentially functional single nucleotide polymorphisms in the core nucleotide excision repair genes and risk of squamous cell carcinoma of the head and neck
    Jiaze An
    Department of Epidemiology, The University of Texas M D Anderson Cancer Center, Unit 1365, 1155 Pressler, Houston, TX 77030, USA
    Cancer Epidemiol Biomarkers Prev 16:1633-8. 2007
    ..These findings suggest that these potentially functional SNPs may collectively contribute to susceptibility to SCCHN. These findings need to be validated in larger, independent studies...
  23. ncbi In vitro sensitivity to ultraviolet B light and skin cancer risk: a case-control analysis
    Li E Wang
    Department of Epidemiology, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    J Natl Cancer Inst 97:1822-31. 2005
    ..However, an association between UV-induced chromosomal aberrations and risk of skin cancer in the general population has not been established...
  24. ncbi Mutagen sensitivity and genetic variants in nucleotide excision repair pathway: genotype-phenotype correlation
    Jie Lin
    Department of Epidemiology, Unit 1340, The University of Texas M D Anderson Cancer Center, 1155 Hermann Pressler Boulevard, Houston, TX 77030, USA
    Cancer Epidemiol Biomarkers Prev 16:2065-71. 2007
    ..As risk assessment for cancer risk is moving toward a multigenic pathway-based approach, future genotype-phenotype correlation studies should also investigate the combined effects of multiple genetic variants...
  25. ncbi XPD/ERCC2 EXON 8 Polymorphisms: rarity and lack of significance in risk of squamous cell carcinoma of the head and neck
    Erich M Sturgis
    Department of Head and Neck Surgery, Box 441, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston 77030 4009, USA
    Oral Oncol 38:475-7. 2002
    ..The objective was to assess whether two polymorphisms in the nucleotide excision repair gene XPD (ERCC2) are markers of SCCHN risk...
  26. pmc Mitochondrial DNA content: its genetic heritability and association with renal cell carcinoma
    Jinliang Xing
    Department of Epidemiology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA
    J Natl Cancer Inst 100:1104-12. 2008
    ..Renal cell carcinoma accounts for 85% of all renal cancers. No studies have investigated the association between mtDNA content and the risk of renal cell carcinoma...
  27. ncbi Association between the V109G polymorphism of the p27 gene and the risk and progression of oral squamous cell carcinoma
    Guojun Li
    Department of Epidemiology, The University of Texas M D Anderson Cancer Center, Houston, Texas, USA
    Clin Cancer Res 10:3996-4002. 2004
    ..We hypothesized that this p27 T109G polymorphism is associated with squamous cell carcinoma of the head and neck (SCCHN) risk...
  28. ncbi Polymorphisms of methionine synthase and methionine synthase reductase and risk of squamous cell carcinoma of the head and neck: a case-control analysis
    Zhengdong Zhang
    Department of Epidemiology, Unit 189, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
    Cancer Epidemiol Biomarkers Prev 14:1188-93. 2005
    ..In conclusion, our data provide evidence that support the association between the MTR A2756G and MTRR G66A polymorphisms and SCCHN risk and that these two polymorphisms may have a joint effect on risk of SCCHN...
  29. ncbi Assessment of insulin-like growth factors and mutagen sensitivity as predictors of lung cancer risk
    Xifeng Wu
    Department of Epidemiology, University of Texas M D Anderson Cancer Center, Houston, TX, USA
    Methods Mol Med 75:279-87. 2003
  30. ncbi Expression of nucleotide excision repair genes and the risk for squamous cell carcinoma of the head and neck
    Lie Cheng
    Department of Epidemiology, University of Texas M D Anderson Cancer Center, Houston 77030, USA
    Cancer 94:393-7. 2002
    ..The objective of this study was to assess the variation in baseline expression of five nucleotide excision repair genes between individuals with SCCHN and cancer free controls...
  31. ncbi Effects of smoking and radiotherapy on lung carcinoma in breast carcinoma survivors
    Melissa B Ford
    Department of Epidemiology, The University of Texas M D Anderson Cancer Center, Houston, Texas, USA
    Cancer 98:1457-64. 2003
    ..The authors analyzed smoking, radiation, and both exposures on lung carcinoma development in women who were treated previously for breast carcinoma...
  32. ncbi Association between glutathione S-transferase p1 polymorphisms and lung cancer risk in Caucasians: a case-control study
    Yunfei Wang
    Department of Epidemiology, The University of Texas M D Anderson Cancer Center, Box 189, 1515 Holcombe Boulevard, Houston, TX 77030, USA
    Lung Cancer 40:25-32. 2003
    ..53; 95% CI 0.21-1.33). These data demonstrate that the GSTP1 exon 6 polymorphism, but not the exon 5 polymorphism, is associated with lung cancer risk that is especially evident in men, younger individuals, and ever smokers...
  33. ncbi Genetic polymorphisms of p21 are associated with risk of squamous cell carcinoma of the head and neck
    Guojun Li
    Department of Epidemiology, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Carcinogenesis 26:1596-602. 2005
    ..001). Our results suggest that the presence of these two p21 polymorphisms may be a marker of genetic susceptibility to SCCHN...
  34. ncbi An association between NQO1 genetic polymorphism and risk of bladder cancer
    Seun Ja Park
    Department of Epidemiology, Unit 189, The University of Texas, M D Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX 77030, USA
    Mutat Res 536:131-7. 2003
    ..78; 95% CI=1.06-3.00), but not in never smokers (OR=1.19; 95% CI=0.65-2.20). These results suggest that the NQO1 genetic polymorphism modulates bladder cancer risk, especially in men and ever smokers...
  35. ncbi Opposing effects of emphysema, hay fever, and select genetic variants on lung cancer risk
    Matthew B Schabath
    Department of Epidemiology, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Am J Epidemiol 161:412-22. 2005
    ..19, 0.66) protective genotypes as compared with none (OR = 0.69, 95% CI: 0.30, 1.59). The biologic role of respiratory disease in lung cancer is unclear. Further study may yield new insights for identification of susceptible subgroups...
  36. ncbi Methylenetetrahydrofolate reductase polymorphisms and risk of squamous cell carcinoma of the head and neck: a case-control analysis
    Ana S Neumann
    Department of Epidemiology, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Int J Cancer 115:131-6. 2005
    ..Future studies should incorporate detailed data on alcohol consumption, dietary folate intake and related serologic measurements...
  37. pmc Dietary alpha-, beta-, gamma- and delta-tocopherols in lung cancer risk
    Somdat Mahabir
    Department of Epidemiology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
    Int J Cancer 123:1173-80. 2008
    ..Given the limitations with case-control studies, these findings need to be confirmed in further investigations...
  38. ncbi Genetic variants in cell cycle control pathway confer susceptibility to lung cancer
    Wei Wang
    Department of Epidemiology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Clin Cancer Res 13:5974-81. 2007
    ..To test the hypothesis that common sequence variants of cell cycle control genes may affect lung cancer predisposition...
  39. ncbi Polymorphisms in XPD exons 10 and 23 and bladder cancer risk
    Matthew B Schabath
    Department of Epidemiology, University of Texas M D Anderson Cancer Center, Unit 189, 1515 Holcombe Boulevard, Houston, TX 77030, USA
    Cancer Epidemiol Biomarkers Prev 14:878-84. 2005
    ....
  40. pmc Genetic variants in inflammation-related genes are associated with radiation-induced toxicity following treatment for non-small cell lung cancer
    Michelle A T Hildebrandt
    Department of Epidemiology, The University of Texas MD Anderson Cancer Center, Houston, Texas, United States of America
    PLoS ONE 5:e12402. 2010
    ..These results suggest that genetic variations among inflammation pathway genes may modulate the development of radiation-induced toxicity and, ultimately, help in identifying patients who are at an increased likelihood for such events...
  41. ncbi Hormone replacement therapy and lung cancer risk: a case-control analysis
    Matthew B Schabath
    Department of Epidemiology, The University of Texas M D Anderson Cancer Center, Houston, Texas, USA
    Clin Cancer Res 10:113-23. 2004
    ..Experimental Design: In a secondary analysis, we compared self-reported HRT use among 499 women with lung cancer and 519 healthy age-matched controls...
  42. ncbi A myeloperoxidase polymorphism associated with reduced risk of lung cancer
    Matthew B Schabath
    Department of Epidemiology, The University of Texas M D Anderson Cancer Center, Box 189, 1515 Holcombe Blvd, Houston, TX 77030, USA
    Lung Cancer 37:35-40. 2002
    ..This report provides further support for the hypothesis that a single nucleotide polymorphism in the MPO gene is a protective factor in lung cancer carcinogenesis...
  43. ncbi Polymorphism of DNA ligase I and risk of lung cancer--a case-control analysis
    Hongbing Shen
    Department of Epidemiology, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
    Lung Cancer 36:243-7. 2002
    ..64-1.36 for AA versus CC) neither in all cases nor in different histopathologic types. The results of this large case-control study suggest that this LIG1 polymorphism may not play an important role in susceptibility to lung cancer...
  44. ncbi From genotype to phenotype: correlating XRCC1 polymorphisms with mutagen sensitivity
    Yunfei Wang
    Department of Epidemiology, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    DNA Repair (Amst) 2:901-8. 2003
    ..To our knowledge, this is the largest study conducted evaluating the functional relevance of these polymorphisms...
  45. ncbi Cytokine genes and pain severity in lung cancer: exploring the influence of TNF-alpha-308 G/A IL6-174G/C and IL8-251T/A
    Cielito C Reyes-Gibby
    Department of Epidemiology, Division of Cancer Prevention, The University of Texas M D Anderson Cancer Center, Unit 1340, 1155 Pressler Street, Houston, TX 77030 4009, USA
    Cancer Epidemiol Biomarkers Prev 16:2745-51. 2007
    ..We explored if polymorphisms in candidate cytokine genes could explain variability in self-reported pain in lung cancer patients of all stages...
  46. pmc Molecular epidemiology, cancer-related symptoms, and cytokines pathway
    Cielito C Reyes-Gibby
    Department of Epidemiology, Division of Cancer Prevention and Population Sciences, The University of Texas, MD Anderson Cancer Center, Houston, TX 77030 4009, USA
    Lancet Oncol 9:777-85. 2008
    ..Likewise, they could identify subgroups who might benefit most from symptom intervention, and contribute to developing personalized and more effective therapies for persistent symptoms...
  47. ncbi A variant of the DNA repair gene XRCC3 and risk of squamous cell carcinoma of the head and neck: a case-control analysis
    Hongbing Shen
    Department of Epidemiology, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Int J Cancer 99:869-72. 2002
    ..26; 95% CI, 1.02-4.99). These findings suggest that the variant XRCC3 18067TT genotype may not play a major role in the etiology of SCCHN but may contribute to a subset of SCCHN. Larger studies are needed to verify these findings...
  48. ncbi BPDE-induced lymphocytic 3p21.3 aberrations may predict head and neck carcinoma risk
    Yong Zhu
    Department of Epidemiology, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
    Cancer 95:563-8. 2002
    ..Chromosomal aberrations in peripheral blood lymphocytes (PBLs) induced by BPDE may reflect individuals' genetic susceptibility to tobacco carcinogens...
  49. ncbi Fas A670G polymorphism, apoptotic capacity in lymphocyte cultures, and risk of lung cancer
    Li E Wang
    Department of Epidemiology, The University of Texas M D Anderson Cancer Center, Houston, TX, USA
    Lung Cancer 42:1-8. 2003
    ..These data suggest that alteration in the apoptotic pathway may be a risk factor for lung cancer and this risk may be modulated by the Fas -A670G polymorphism. Larger prospective studies are needed to verify these findings...
  50. ncbi Association between asbestos exposure, cigarette smoking, myeloperoxidase (MPO) genotypes, and lung cancer risk
    Matthew B Schabath
    Department of Epidemiology, The University of Texas M D Anderson Cancer Center, Holcombe Blvd, Houston, Texas 77303, USA
    Am J Ind Med 42:29-37. 2002
    ..As observed in tobacco-associated carcinogenesis, genetic factors such as the polymorphic metabolic/oxidative enzyme myeloperoxidase (MPO) could modulate individual susceptibility to asbestos-associated carcinogenesis...
  51. ncbi Genetic instability in bladder cancer assessed by the comet assay
    Matthew B Schabath
    Department of Epidemiology, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    J Natl Cancer Inst 95:540-7. 2003
    ..We used the comet assay (single-cell gel electrophoresis) to assess whether genetic instability, as reflected by susceptibility to DNA damage, was associated with the risk of bladder cancer in a case-control study...
  52. ncbi Dietary carotenoids and genetic instability modify bladder cancer risk
    Matthew B Schabath
    Department of Epidemiology, The University of Texas M D Anderson Cancer Center, Houston, TX, USA
    J Nutr 134:3362-9. 2004
    ..18; 95% CI, 1.13-4.22). This study provides evidence of a preventive role for carotenoids in bladder cancer, and these data may have important implications for cancer prevention, especially for individuals susceptible to DNA damage...
  53. ncbi An evolutionary perspective on single-nucleotide polymorphism screening in molecular cancer epidemiology
    Yong Zhu
    Department of Epidemiology, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
    Cancer Res 64:2251-7. 2004
    ..Using such a molecular evolutionary approach may hold great promise for prioritizing SNPs to be genotyped in future molecular epidemiological studies...
  54. ncbi Association of a p73 exon 2 G4C14-to-A4T14 polymorphism with risk of squamous cell carcinoma of the head and neck
    Guojun Li
    Department of Epidemiology, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Carcinogenesis 25:1911-6. 2004
    ..70; 95% CI, 1.19-2.43), women (1.61; 1.09-2.37), current smokers (1.77; 1.25-2.51) and patients with oral cancer (1.54; 1.15-2.07). Our results suggest that this p73 polymorphism may be a risk marker for genetic susceptibility to SCCHN...
  55. pmc ATM sequence variants associate with susceptibility to non-small cell lung cancer
    Hushan Yang
    Department of Epidemiology, The University of Texas M D Anderson Cancer Center, Houston, TX
    Int J Cancer 121:2254-9. 2007
    ....
  56. ncbi Modification of lung cancer susceptibility by green tea extract as measured by the comet assay
    Huifeng Zhang
    Department of Epidemiology, The University of Texas M D Anderson Cancer Center Box 189 1515 Holcombe Blvd, Houston, TX 77030, USA
    Cancer Detect Prev 26:411-8. 2002
    ..This reports also demonstrated the chemopreventive effects of green tea extract on BPDE-induced DNA damage. These observations provide further support for the application of the comet assay in molecular epidemiologic studies...
  57. ncbi DNA repair gene XRCC3 241Met variant is not associated with risk of cutaneous malignant melanoma
    Zhigang Duan
    Departments of Epidemiology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Cancer Epidemiol Biomarkers Prev 11:1142-3. 2002
  58. ncbi No Association between hOGG1 Ser326Cys polymorphism and risk of squamous cell carcinoma of the head and neck
    Zhengdong Zhang
    Department of Epidemiology, University of Texas M D Anderson Cancer Center, Houston, 77030, USA
    Cancer Epidemiol Biomarkers Prev 13:1081-3. 2004
  59. ncbi P53 codon 72 polymorphism and risk of squamous cell carcinoma of the head and neck: a case-control study
    Hongbing Shen
    Department of Epidemiology, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Cancer Lett 183:123-30. 2002
    ..Arg/Arg; P=0.066 for Pro/Pro and Arg/Pro combined vs. Arg/Arg). While the results suggest that the P53 codon 72 polymorphism may contribute to oral cancer susceptibility, larger studies are needed to confirm these findings...
  60. ncbi Human papillomavirus type 16 infection and squamous cell carcinoma of the head and neck in never-smokers: a matched pair analysis
    Kristina R Dahlstrom
    Departments of Head and Neck Surgery, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Clin Cancer Res 9:2620-6. 2003
    ..Serum was collected from study subjects and assayed for IgG reactivity to HPV-16 L1 virus-like particles by using an ELISA...
  61. ncbi Methyl-CpG-binding domain 2: a protective role in bladder carcinoma
    Yong Zhu
    Department of Epidemiology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Cancer 100:1853-8. 2004
    ..In the current case-control study, the authors investigated the association between MBD2 expression and bladder carcinoma risk...
  62. ncbi A case-control analysis of lymphocytic chromosome 9 aberrations in lung cancer
    Yong Zhu
    Department of Epidemiology, The University of Texas M D Anderson Cancer Center, Houston, TX, USA
    Int J Cancer 102:536-40. 2002
    ..67 [0.84, 3.32]) and lung cancer (OR = 2.49 [0.81, 7.67]). Our findings suggest that chromosome 9 aberrations in PBLs might be considered a marker of lung cancer predisposition and may be associated with familial aggregation of cancer...
  63. ncbi Thymidylate synthase 5'- and 3'-untranslated region polymorphisms associated with risk and progression of squamous cell carcinoma of the head and neck
    Zhengdong Zhang
    Department of Epidemiology, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
    Clin Cancer Res 10:7903-10. 2004
    ..We hypothesized that polymorphisms of the thymidylate synthase (TYMS) gene, which regulates a key enzyme in folate metabolism required for DNA synthesis and repair, are associated with SCCHN risk...
  64. ncbi Sulfotransferase (SULT) 1A1 polymorphism as a predisposition factor for lung cancer: a case-control analysis
    Yunfei Wang
    Department of Epidemiology, The University of Texas, M D Anderson Cancer Center, Box 189, 1515 Holcombe Blvd, Houston, TX 77030, USA
    Lung Cancer 35:137-42. 2002
    ..74, 95% CI: 1.08-2.29) and heavy smokers (OR=1.45, 95% CI: 1.05-2.00). Our results support the hypothesis that a genetic polymorphism in the SULT1A1 gene may be associated with increased lung cancer risk...
  65. ncbi Polymorphisms of FAS and FAS ligand genes involved in the death pathway and risk and progression of squamous cell carcinoma of the head and neck
    Zhengdong Zhang
    Department of Epidemiology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Clin Cancer Res 12:5596-602. 2006
    ....
  66. ncbi 172G>T variant in the 5' untranslated region of DNA repair gene RAD51 reduces risk of squamous cell carcinoma of the head and neck and interacts with a P53 codon 72 variant
    Jiachun Lu
    Department of Epidemiology, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Carcinogenesis 28:988-94. 2007
    ..The finding that the functional RAD51 172G>T SNP, particularly in the presence of the P53 Arg72Arg genotype, may be a marker of susceptibility to SCCHN needs to be validated by larger studies of different ethnic populations...
  67. ncbi Association of genetic variants of O6-methylguanine-DNA methyltransferase with risk of lung cancer in non-Hispanic Whites
    Luo Wang
    Department of Epidemiology, The University of Texas M D Anderson Cancer Center, Unit 1365, 1515 Holcombe Boulevard, Houston, TX 77030, USA
    Cancer Epidemiol Biomarkers Prev 15:2364-9. 2006
    ..Our findings suggest that non-synonymous SNPs in MGMT are associated with modestly increased risk of lung cancer in Caucasians and need to be further investigated...
  68. pmc Mediating effects of smoking and chronic obstructive pulmonary disease on the relation between the CHRNA5-A3 genetic locus and lung cancer risk
    Jian Wang
    Department of Epidemiology, The University of Texas M D Anderson Cancer Center, Houston, Texas
    Cancer 116:3458-62. 2010
    ..However, it has not been established whether the association between genetic variants and lung cancer risk is a direct one or one mediated by nicotine dependence...
  69. ncbi Overexpression of hMTH in peripheral lymphocytes and risk of prostate cancer: a case-control analysis
    Zhensheng Liu
    Department of Epidemiology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Mol Carcinog 36:123-9. 2003
    ..In addition, a correlation between the expression level of hMTH and the level of oxidative DNA damage in the target tissues needs to be established as well...
  70. ncbi A modified host-cell reactivation assay to measure repair of alkylating DNA damage for assessing risk of lung adenocarcinoma
    Luo Wang
    Department of Epidemiology, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
    Carcinogenesis 28:1430-6. 2007
    ..We conclude that variability in DRC is a risk factor for lung cancer and our results provide proof of principle for a new assay that can assess DRC for NNK-induced DNA damage...
  71. pmc Cognitive susceptibility to smoking: Two paths to experimenting among Mexican origin youth
    Amy R Spelman
    Department of Epidemiology, The University of Texas M D Anderson Cancer Center, Houston, 77030, USA
    Cancer Epidemiol Biomarkers Prev 18:3459-67. 2009
    ..Our results suggest that tailoring primary prevention programs by a youth's susceptibility status may increase the efficacy of prevention efforts among Mexican origin youth...
  72. pmc Novel susceptibility loci for second primary tumors/recurrence in head and neck cancer patients: large-scale evaluation of genetic variants
    Xifeng Wu
    Department of Epidemiology, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
    Cancer Prev Res (Phila) 2:617-24. 2009
    ..Furthermore, this study underscores the importance of incorporating germ-line genetic variation data with clinical and risk factor data in constructing prediction models for clinical outcomes...
  73. ncbi Differential induction in telomerase activity among bladder cancer patients and controls on gamma-radiation
    Jinliang Xing
    Department of Epidemiology, The University of Texas M D Anderson Cancer Center, Unit 1304, 1155 Pressler Boulevard, Houston, TX 77030, USA
    Cancer Epidemiol Biomarkers Prev 16:606-9. 2007
    ..Our findings provide the first evidence linking the mutagen-induced telomerase activity in peripheral blood lymphocytes to the risk of bladder cancer, which warrants further investigation in large-sized studies and other cancer types...
  74. ncbi Polymorphisms of STK15 (Aurora-A) gene and lung cancer risk in Caucasians
    Jian Gu
    Department of Epidemiology, The University of Texas M D Anderson Cancer Center Houston, TX 77030, USA
    Carcinogenesis 28:350-5. 2007
    ..45% of controls) exhibited a reduced lung cancer risk (OR=0.78, 95% CI=0.63-0.97). This is the first epidemiological study to report significant associations between STK15 polymorphisms and lung cancer risk...
  75. pmc Polymorphisms of cytosolic serine hydroxymethyltransferase and risk of lung cancer: a case-control analysis
    Luo Wang
    Department of Epidemiology, The University of Texas M D Anderson Cancer Center, Houston, TX 77230 1439, United States
    Lung Cancer 57:143-51. 2007
    ..These results suggest that SHMT1 variants may play a role in the etiology of lung cancer, and our findings need to be verified in larger prospective studies...
  76. ncbi Rapid assessment of repair of ultraviolet DNA damage with a modified host-cell reactivation assay using a luciferase reporter gene and correlation with polymorphisms of DNA repair genes in normal human lymphocytes
    Yawei Qiao
    Department of Epidemiology, Box 189, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX 77030, USA
    Mutat Res 509:165-74. 2002
    ..These features make the LUC-based HCR assay suitable for molecular epidemiological studies...
  77. ncbi A modified host cell reactivation assay to measure DNA repair capacity for removing 4-aminobiphenyl adducts: a pilot study of bladder cancer
    Jie Lin
    Department of Epidemiology, University of Texas M D Anderson Cancer Center, Unit 1340, 1155 Hermann Pressler Boulevard, Houston, TX 77030, USA
    Cancer Epidemiol Biomarkers Prev 14:1832-6. 2005
    ..Our assay provides a new tool to specifically quantify DNA repair capacity in bladder cancer studies and, therefore, contributes to our goal of further elucidating bladder carcinogenesis...
  78. ncbi Dietary folate intake and lung cancer risk in former smokers: a case-control analysis
    Hongbing Shen
    Department of Epidemiology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Cancer Epidemiol Biomarkers Prev 12:980-6. 2003
    ..Our data suggest that there is a possible protective role of dietary folate in lung carcinogenesis, a finding which may have implications in public health and cancer prevention...
  79. ncbi Clinicopathologic characteristics of the EGFR gene mutation in non-small cell lung cancer
    Anne S Tsao
    Department of Thoracic Head and Neck Medical Oncology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030 4009, USA
    J Thorac Oncol 1:231-9. 2006
    ..The authors sought to define clinicopathologic features associated with mutations of the epidermal growth factor receptor (EGFR) gene in non-small cell lung cancer (NSCLC)...
  80. ncbi Genetic susceptibility for lung cancer: interactions with gender and smoking history and impact on early detection policies
    Olga Y Gorlova
    University of Texas M D Anderson Cancer Center, Houston, Tex, USA
    Hum Hered 56:139-45. 2003
    ....
  81. pmc Gender differences in sociodemographic and behavioral influences of physical activity in Mexican-origin adolescents
    Larkin L Strong
    Department of Health Disparities Research, University of Texas M D Anderson Cancer Center, Houston, TX, USA
    J Phys Act Health 9:829-39. 2012
    ..Understanding the factors that contribute to physical activity (PA) in Mexican-origin adolescents is essential to the design of effective efforts to enhance PA participation in this population...
  82. doi Chapter 11: Rice-MD Anderson lung cancer model
    Millennia Foy
    Brown Foundation Institute of Molecular Medicine, University of Texas Health Science Center at Houston, Houston, TX 77030, USA
    Risk Anal 32:S142-50. 2012
    ..Simulation results show that tobacco control policies have achieved 35% of the reduction in lung cancer mortality that would have resulted from cessation of all smoking in 1965...
  83. ncbi Smoking affects treatment outcome in patients with advanced nonsmall cell lung cancer
    Anne S Tsao
    Department of Thoracic Head and Neck Medical Oncology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Cancer 106:2428-36. 2006
    ..The purpose of the current study was to determine whether smoking during chemotherapy or chemoradiation therapy for nonsmall cell lung cancer (NSCLC) affects treatment outcome...
  84. ncbi Mutagen sensitivity and neoplastic progression in patients with Barrett's esophagus: a prospective analysis
    Dennis L Chao
    Division of Human Biology, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, C1 157, Seattle, WA 98109, USA
    Cancer Epidemiol Biomarkers Prev 15:1935-40. 2006
    ....
  85. ncbi Myeloperoxidase G-463A polymorphism and lung cancer: a HuGE genetic susceptibility to environmental carcinogens pooled analysis
    Emanuela Taioli
    University of Pittsburgh, Cancer Institute, Pittsburgh, Pensylvania 15232, USA
    Genet Med 9:67-73. 2007
    ..The myeloperoxidase G-463A polymorphism was significantly protective in "ever" smokers but not in "never" smokers. Myeloperoxidase is a key enzyme in tobacco-induced carcinogenesis...
  86. pmc Familial aggregation of common sequence variants on 15q24-25.1 in lung cancer
    Pengyuan Liu
    Washington University, St Louis, MO 63110, USA
    J Natl Cancer Inst 100:1326-30. 2008
    ..67, CI = 2.21 to 14.60, both of which were located in the 15q24-25.1 locus, than among control subjects. Thus, further research to elucidate causal variants in the 15q24-25.1 locus that are associated with lung cancer is warranted...
  87. pmc Meta-analysis and pooled analysis of GSTM1 and CYP1A1 polymorphisms and oral and pharyngeal cancers: a HuGE-GSEC review
    Leonor Varela-Lema
    Department of Preventive Medicine and Public Health, University of Santiago de Compostela, Santiago de Compostela, Spain
    Genet Med 10:369-84. 2008
    ..1-4.5) in ever smokers. A joint effect was observed for GSTM1 homozygous deletion and the CYP1A1 m1m2 variant on cancer risk. Our findings suggest that tobacco use and genetic factors play a significant role in oral and pharyngeal cancer...

Research Grants35

  1. CLINICAL AND EPIDEMIOLOGIC CENTER FOR BIOMARKERS OF UPPE
    Margaret Spitz; Fiscal Year: 2004
    ..The team of investigators is multi-disciplinary and will be able to respond in a timely and flexible manner to network directives, and to enhance and augment the network's research capabilities. ..
  2. Adenocarcinoma of the Lung: role of NNK susceptibility
    Margaret Spitz; Fiscal Year: 2004
    ..This research is also applicable to other sites since tobacco-specific nitrosamines are causative agents in esophagus, pancreas and oral cavity cancers, and are the most prevalent carcinogen in snuff products. ..
  3. Biobehavioral-Smoking Profiles in Mexican-American Youth
    Margaret Spitz; Fiscal Year: 2004
    ..These findings will enable us to develop culturally and age-appropriate school- and community-based smoking cessation interventions. ..
  4. Adenocarcinoma of the Lung: role of NNK susceptibility
    Margaret Spitz; Fiscal Year: 2005
    ..This research is also applicable to other sites since tobacco-specific nitrosamines are causative agents in esophagus, pancreas and oral cavity cancers, and are the most prevalent carcinogen in snuff products. ..
  5. Biobehavioral-Smoking Profiles in Mexican-American Youth
    Margaret Spitz; Fiscal Year: 2005
    ..These findings will enable us to develop culturally and age-appropriate school- and community-based smoking cessation interventions. ..
  6. Adenocarcinoma of the Lung: role of NNK susceptibility
    Margaret Spitz; Fiscal Year: 2006
    ..This research is also applicable to other sites since tobacco-specific nitrosamines are causative agents in esophagus, pancreas and oral cavity cancers, and are the most prevalent carcinogen in snuff products. ..
  7. Biobehavioral-Smoking Profiles in Mexican-American Youth
    Margaret Spitz; Fiscal Year: 2006
    ..These findings will enable us to develop culturally and age-appropriate school- and community-based smoking cessation interventions. ..
  8. Adenocarcinoma of the Lung: role of NNK susceptibility
    Margaret Spitz; Fiscal Year: 2007
    ..This research is also applicable to other sites since tobacco-specific nitrosamines are causative agents in esophagus, pancreas and oral cavity cancers, and are the most prevalent carcinogen in snuff products. ..
  9. Biobehavioral-Smoking Profiles in Mexican-American Youth
    Margaret Spitz; Fiscal Year: 2007
    ..These findings will enable us to develop culturally and age-appropriate school- and community-based smoking cessation interventions. ..
  10. Inflammation Genes and Lung Cancer Risk
    Margaret Spitz; Fiscal Year: 2009
    ..Finally we will incorporate these findings into an extended risk prediction model for lung cancer. ..
  11. ECOGENETICS OF LUNG CANCER IN MINORITY POPULATIONS
    Margaret Spitz; Fiscal Year: 1991
    ..The use of genetic markers of risk enhances the power of this multidisciplinary epidemiologic research project...
  12. ECOGENETICS OF LUNG CANCER IN MINORITY POPULATIONS
    Margaret Spitz; Fiscal Year: 1992
    ..The use of genetic markers of risk enhances the power of this multidisciplinary epidemiologic research project...
  13. ECOGENETICS OF LUNG CANCER IN MINORITY POPULATIONS
    Margaret Spitz; Fiscal Year: 1993
    ..The use of genetic markers of risk enhances the power of this multidisciplinary epidemiologic research project...
  14. Inflammation Genes and Lung Cancer Risk
    Margaret R Spitz; Fiscal Year: 2010
    ..The public health potential of a useful risk prediction modes for lung cancer is substantial. ..