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Genomes and Genes | Jonathan M SpergelSummaryAffiliation: The Children's Hospital of Philadelphia Country: USA Publications
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Publications
The use of patch testing in the diagnosis of food allergyJonathan M Spergel
Allergy Section, Division of Allergy and Immunology, The Children s Hospital of Philadelphia, 34th Street and Civic Center Boulevard, Wood 5, Philadelphia, PA 19104, USA
Curr Allergy Asthma Rep 5:86-90. 2005..In this article, we review literature regarding patch testing: its methods, its statistical usefulness, and its potential future role...- Eosinophilic esophagitis in adults and children: evidence for a food allergy component in many patientsJonathan M Spergel
Division of Allergy and Immunology, Children s Hospital of Philadelphia, University of Pennsylvania School of Medicine, 34 and Civic Center Boulevard, Philadelphia, PA 19104, USA
Curr Opin Allergy Clin Immunol 7:274-8. 2007..This article reviews all literature published in English from December 2005 to November 2006 from PubMed on the topic of eosinophilic esophagitis... 
14 years of eosinophilic esophagitis: clinical features and prognosisJonathan M Spergel
Division of Allergy and Immunology, The Children s Hospital of Philadelphia, USA
J Pediatr Gastroenterol Nutr 48:30-6. 2009..To determine the natural history of treated and untreated eosinophilic esophagitis (EE) and examine the presenting symptoms of EE...- Identification of causative foods in children with eosinophilic esophagitis treated with an elimination dietJonathan M Spergel
Division of Allergy and Immunology, Children s Hospital of Philadelphia, Philadelphia, PA 19104 4399, USA
J Allergy Clin Immunol 130:461-7.e5. 2012..Eosinophilic esophagitis (EoE) is a chronic inflammatory disease with isolated eosinophils in the esophagus predominantly triggered by foods. The optimal testing to identify inciting foods remains unclear... - Treatment of eosinophilic esophagitis with specific food elimination diet directed by a combination of skin prick and patch testsJonathan M Spergel
Division of Allergy and Immunology, The Children s Hospital of Philadelphia, Pennsylvania 19104 4399, USA
Ann Allergy Asthma Immunol 95:336-43. 2005..Therapies have included corticosteroids, elemental diet, and diet restriction. We report our experience with skin prick and atopy patch testing and food elimination diets in patients diagnosed as having EE... 
The link between allergies and eosinophilic esophagitis: implications for management strategiesTerri F Brown-Whitehorn
Division of Allergy and Immunology, The Children s Hospital of Philadelphia, Department of Pediatrics, University of Pennsylvania School of Medicine, 3550 Market Street, Philadelphia, PA 19104, USA
Expert Rev Clin Immunol 6:101-9. 2010..However, differences do exist between the diseases in treatment and pathogenesis. For EE, there are two basic treatment options: avoidance of the food triggers or treatment of the eosinophilic inflammation with corticosteroids...- Predictive values for food challenge-induced severe reactions: development of a simple food challenge scoreAntonella Cianferoni
Department of Pediatrics, Division of Allergy and Immunology, Children s Hospital of Philadelphia, Philadelphia, PA, USA
Isr Med Assoc J 14:24-8. 2012..Skin-prick tests (SPT), food-specific immunoglobulin E level (sIgE) and clinical history have limited value individually in predicting the severity of outcome of the oral food challenge (OFC)... - Association of eosinophilic gastrointestinal disorders with other atopic disordersSoma Jyonouchi
Division of Allergy and Immunology, The Children s Hospital of Philadelphia, University of Pennsylvania School of Medicine, 34th Street and Civic Center Boulevard, Philadelphia, PA 19104, USA
Immunol Allergy Clin North Am 29:85-97, x. 2009..Finally, most patients who have eosinophilic gastrointestinal disorders have an associated atopic disease... - Reslizumab in children and adolescents with eosinophilic esophagitis: results of a double-blind, randomized, placebo-controlled trialJonathan M Spergel
Division of Allergy and Immunology, Department of Pediatrics, Children s Hospital of Philadelphia, Philadelphia, PA 19104, USA
J Allergy Clin Immunol 129:456-63, 463.e1-3. 2012..Eosinophilic esophagitis is a chronic allergic disease with insufficient treatment options. Results from animal studies suggest that IL-5 induces eosinophil trafficking in the esophagus... - Eosinophilic esophagitis: a 10-year experience in 381 childrenChris A Liacouras
Division of Gastroenterology and Nutrition, The Children s Hospital of Philadelphia, Philadelphia, Pennsylvania 19104, USA
Clin Gastroenterol Hepatol 3:1198-206. 2005..We present information relating to our 10-year experience in children diagnosed with EoE... - Common variants at 5q22 associate with pediatric eosinophilic esophagitisMarc E Rothenberg
Division of Allergy and Immunology, Department of Pediatrics, Cincinnati Children s Hospital Medical Center, University of Cincinnati, Cincinnati, Ohio, USA
Nat Genet 42:289-91. 2010..These data implicate the 5q22 locus in the pathogenesis of EoE and identify TSLP as the most likely candidate gene in the region... - From atopic dermatitis to asthma: the atopic marchJonathan M Spergel
Division of Allergy and Immunology, The Children s Hospital of Philadelphia, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104 4399, USA
Ann Allergy Asthma Immunol 105:99-106; quiz 107-9, 117. 2010..To examine the mechanisms whereby allergen exposure through the epidermis could initiate systemic allergy and predispose individuals to the development of 1 or more atopic diseases via the so-called atopic march... - Food allergy: review, classification and diagnosisAntonella Cianferoni
Division of Allergy and Immunology, Department of Pediatrics, The Children s Hospital of Philadelphia, University of Pennsylvania School of Medicine, Philadelphia 19104, USA
Allergol Int 58:457-66. 2009..However, novel strategies are being studied, including sublingual/oral immunotherapy and others with a hope for future... - Atopy patch test for the diagnosis of food protein-induced enterocolitis syndromeMatthew I Fogg
Division of Allergy and Immunology, Children's Hospital of Philadelphia, PA 19104, USA
Pediatr Allergy Immunol 17:351-5. 2006..All 12 patients with a negative APT had a negative oral food challenge to the suspected food. APT appears to be a promising diagnostic tool for the diagnosis of FPIES... - Food Intolerance and childhood asthma: what is the link?Janet L Beausoleil
Division of Allergy and Immunology, The Children s Hospital of Philadelphia, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
Paediatr Drugs 9:157-63. 2007..However, similar to skin testing and the RAST, there is good sensitivity but poor specificity, such that specific challenges are often warranted... - Invariant natural killer T cells from children with versus without food allergy exhibit differential responsiveness to milk-derived sphingomyelinSoma Jyonouchi
Division of Allergy and Immunology, The Children s Hospital of Philadelphia, Philadelphia, PA 19104, USA
J Allergy Clin Immunol 128:102-109.e13. 2011..Major food allergens (eg, milk, egg) are the richest dietary source of sphingolipids (food-derived sphingolipids [food-SLs]). Nonetheless, the role of iNKTs in FA is unknown... - Nonimmunoglobulin e-mediated immune reactions to foodsJonathan M Spergel
Assistant Professor of Pediatrics, Division of Allergy and Immunology, Department of Pediatrics, The Children s Hospital of Philadelphia, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania
Allergy Asthma Clin Immunol 2:78-85. 2006..The most recent evidence suggests that these reactions are probably T-cell mediated as evidenced in lymphocyte proliferation assays. This review will explore the symptoms and testing methods of the most common non-IgE-mediated reactions... - Food allergy. Mechanisms, diagnosis, and management in childrenJonathan M Spergel
Allergy Section, Division of Immunologic and Infectious Diseases, Children s Hospital of Philadelphia, USA
Pediatr Clin North Am 49:73-96, vi. 2002..Many people believe that they have an allergic reaction to foods; however, the actual incidence confirmed by history and challenges suggests a prevalence rate closer to 2% to 8% in young infants and less than 2% in adults... - New genetic links in eosinophilic esophagitisJonathan M Spergel
Division of Allergy and Immunology, Department of Pediatrics, The Children s Hospital of Philadelphia, University of Pennsylvania School of Medicine, 3550 Market Street, Philadelphia, PA 19104, USA
Genome Med 2:60. 2010..Identification of this molecule and its receptor suggest the potential for new treatment options in the future... - Filaggrin mutations and atopy: consequences for future therapeuticsJennifer Heimall
The Children s Hospital of Philadelphia, Division of Allergy and Immunology, 550 Market Street, PA 19104, USA
Expert Rev Clin Immunol 8:189-97. 2012..It is on this foundation that therapies aimed at restoration of barrier function are thought to play a role, not only in the effective treatment of atopic eczema, but also in the prevention of further allergic disease development... - Nutritional management of eosinophilic esophagitisJonathan M Spergel
Division of Allergy and Immunology, Wood Building 5314, The Children s Hospital of Philadelphia, 34th and Civic Center Boulevard, Philadelphia, PA 19104, USA
Gastrointest Endosc Clin N Am 18:179-94; xi. 2008..This article discusses the nutritional risks and benefits of each approach... - TSLP promotes interleukin-3-independent basophil haematopoiesis and type 2 inflammationMark C Siracusa
Institute for Immunology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
Nature 477:229-33. 2011.... - Correlation of initial food reactions to observed reactions on challengesJonathan M Spergel
Division of Allergy and Immunology, The Children s Hospital of Philadelphia, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
Ann Allergy Asthma Immunol 92:217-24. 2004..These reactions can vary from mild cutaneous manifestations to severe life-threatening reactions. Limited information is available on which specific factors may predict the severity of subsequent reactions... - Late diagnosis of tree nut and sesame allergy in patients previously sensitized but tolerant to peanutJanet L Beausoleil
Division of Allergy and Immunology, The Children s Hospital of Philadelphia, Philadelphia, Pennsylvania 19104, USA
Ann Allergy Asthma Immunol 97:443-5. 2006..Although the coexistence may be simply due to a predisposition to food allergy in these individuals, cross-reactivity has been demonstrated between peanut and tree nuts and between peanut and sesame seed... - The use of skin prick tests and patch tests to identify causative foods in eosinophilic esophagitisJonathan M Spergel
Allergy Section, Division of Immunologic and Infectious Disease, The Children's Hospital of Philadelphia, PA 19104, USA
J Allergy Clin Immunol 109:363-8. 2002..CONCLUSION: The combination of skin prick testing and patch testing can identify potential causative foods that might contribute to the pathogenesis of eosinophilic esophagitis... - Food allergy and additives: triggers in asthmaJonathan M Spergel
Department of Pediatrics, Division of Allergy and Immunology, The Children s Hospital of Philadelphia, University of Pennsylvania School of Medicine, 34th Sreet and Civic Center Blvd, Philadelphia, PA 19104, USA
Immunol Allergy Clin North Am 25:149-67. 2005..Susceptible patients may even react to a causative food on inhalation without ingestion. However, isolated asthma or rhinitis symptoms without concomitant cutaneous or gastrointestinal symptoms are rare events... - Otolaryngologists may not be doing enough to diagnose pediatric eosinophilic esophagitisLee P Smith
Division of Pediatric Otolaryngology, The Children s Hospital of Philadelphia, Philadelphia, PA 19104 4399, USA
Int J Pediatr Otorhinolaryngol 73:1554-7. 2009..To systematically evaluate the diagnosis of eosinophilic esophagitis (EE)... - Elemental diet is an effective treatment for eosinophilic esophagitis in children and adolescentsJonathan E Markowitz
Divisions of Gastroenterology and Nutrition, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania 19104, USA
Am J Gastroenterol 98:777-82. 2003..5 days. CONCLUSIONS: Elemental diet resulted in striking improvement in both symptoms and histologic evidence of disease in children and adolescents with EoE, as identified by strict diagnostic criteria... - Variation in prevalence, diagnostic criteria, and initial management options for eosinophilic gastrointestinal diseases in the United StatesJonathan M Spergel
Division of Allergy and Immunology, Department of Pediatrics, The Children s Hospital of Philadelphia, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
J Pediatr Gastroenterol Nutr 52:300-6. 2011..The aim of the present study was to define the regional and national prevalence of eosinophilic gastrointestinal diseases, and differences in practice approaches... - Atopic dermatitis and the atopic marchJonathan M Spergel
Division of Allergy and Immunology, The Children's Hospital of Philadelphia, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
J Allergy Clin Immunol 112:S118-27. 2003..Animal models and human observation concur with this theory. Preliminary prevention studies with oral antihistamines provide evidence that early intervention might slow the atopic march... - Correlation of exhaled nitric oxide, spirometry and asthma symptomsJonathan M Spergel
Allergy Section, Division of Allergy and Immunology, The Children s Hospital of Philadelphia, Philadelphia, PA 19104, USA
J Asthma 42:879-83. 2005..FeNO had a strong correlation than FEV1. FeNO and FEV1 were not correlated. We propose that FeNO should be used as an additional monitoring tool for asthma... - Epidemiology of atopic dermatitis and atopic march in childrenJonathan M Spergel
Division of Allergy and Immunology, The Children s Hospital of Philadelphia, University of Pennsylvania School of Medicine, 3550 Market Street, Philadelphia, PA 19104, USA
Immunol Allergy Clin North Am 30:269-80. 2010..Patients with atopic sensitization along with eczema are at a higher risk for progressing in the atopic march to asthma. The main risk factors for progression and persistence of asthma are early onset and severity of AD... - Management of food allergiesMatthew I Fogg
Division of Allergy and Immunology, The Children s Hospital of Philadelphia, University of Pennsylvania School of Medicine, 34th Street and Civic Center Blvd, Philadelphia, PA 19104, USA
Expert Opin Pharmacother 4:1025-37. 2003..The management of food allergy will also be discussed with particular emphasis on the avoidance of food allergens and the pharmacotherapy of allergic reactions. Future therapy for food allergies will also be discussed... - A case-control study of sociodemographic and geographic characteristics of 335 children with eosinophilic esophagitisJames P Franciosi
Division of Gastroenterology, Hepatology and Nutrition, The Children s Hospital of Philadelphia, Philadelphia, Pennsylvania, USA
Clin Gastroenterol Hepatol 7:415-9. 2009..The epidemiology of pediatric eosinophilic esophagitis (EE) is poorly characterized. In this study, we aimed to determine demographic, socioeconomic, and geographic characteristics of our cohort of EE children... - Atopic march: link to upper airwaysJonathan M Spergel
Division of Allergy and Immunology, Department of Pediatrics, The Children s Hospital of Philadelphia, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
Curr Opin Allergy Clin Immunol 5:17-21. 2005..Evidence examining the theory that allergic rhinitis precedes asthma will be discussed. In addition, the role of allergic rhinitis as an end point in the atopic march will be reviewed... - Eosinophilic esophagitis: updated consensus recommendations for children and adultsChris A Liacouras
Center for Pediatric Eosinophilic Disorders, Division of Gastroenterology, Hepatology, and Nutrition, The Children s Hospital of Philadelphia, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
J Allergy Clin Immunol 128:3-20.e6; quiz 21-2. 2011..Further advances and controversies regarding diagnostic methods, surrogate disease markers, allergy testing, and treatment approaches are discussed... - Variants of DENND1B associated with asthma in childrenPatrick M A Sleiman
Center for Applied Genomics, Philadelphia, PA 19104 4318, USA
N Engl J Med 362:36-44. 2010..Asthma is a complex disease that has genetic and environmental causes. The genetic factors associated with susceptibility to asthma remain largely unknown... - Immunology and treatment of atopic dermatitisJonathan M Spergel
Allergy Section, Division of Allergy and Immunology, The Children s Hospital of Philadelphia, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 4399, USA
Am J Clin Dermatol 9:233-44. 2008..Together, TCSs and TCIs represent the backbone of a long-term treatment strategy for AD... - Effect of topical pimecrolimus on epicutaneous skin testingJonathan M Spergel
J Allergy Clin Immunol 114:695-7. 2004 - Authors' response to detection of causative foods by skin prick and atopy patch tests in patients with eosinophilic esophagitis: things are not what they seemJonathan M Spergel
Ann Allergy Asthma Immunol 96:376-8. 2006 - Pollen and eosinophilic esophagitisMatthew I Fogg
J Allergy Clin Immunol 112:796-7. 2003 - Safety of topical calcineurin inhibitors in atopic dermatitis: evaluation of the evidenceJonathan M Spergel
Curr Allergy Asthma Rep 6:270-4. 2006..To date, studies from clinical trials, systemic absorption, and post-marketing surveillance show no evidence for this systemic immunosuppression or increased risk for any malignancy... - Predictive values for skin prick test and atopy patch test for eosinophilic esophagitisJonathan M Spergel
J Allergy Clin Immunol 119:509-11. 2007 - The black box warning for topical calcineurin inhibitors: looking outside the boxLuz Fonacier
Winthrop University Hospital, State University of New York, Stony Brook School of Medicine, New York, USA
Ann Allergy Asthma Immunol 97:117-20. 2006