Jonathan M Spergel

Summary

Affiliation: The Children's Hospital of Philadelphia
Country: USA

Publications

  1. ncbi request reprint The use of patch testing in the diagnosis of food allergy
    Jonathan M Spergel
    Allergy Section, Division of Allergy and Immunology, The Children s Hospital of Philadelphia, 34th Street and Civic Center Boulevard, Wood 5, Philadelphia, PA 19104, USA
    Curr Allergy Asthma Rep 5:86-90. 2005
  2. ncbi request reprint Eosinophilic esophagitis in adults and children: evidence for a food allergy component in many patients
    Jonathan M Spergel
    Division of Allergy and Immunology, Children s Hospital of Philadelphia, University of Pennsylvania School of Medicine, 34 and Civic Center Boulevard, Philadelphia, PA 19104, USA
    Curr Opin Allergy Clin Immunol 7:274-8. 2007
  3. doi request reprint 14 years of eosinophilic esophagitis: clinical features and prognosis
    Jonathan M Spergel
    Division of Allergy and Immunology, The Children s Hospital of Philadelphia, USA
    J Pediatr Gastroenterol Nutr 48:30-6. 2009
  4. doi request reprint Identification of causative foods in children with eosinophilic esophagitis treated with an elimination diet
    Jonathan M Spergel
    Division of Allergy and Immunology, Children s Hospital of Philadelphia, Philadelphia, PA 19104 4399, USA
    J Allergy Clin Immunol 130:461-7.e5. 2012
  5. pmc Thymic stromal lymphopoietin-elicited basophil responses promote eosinophilic esophagitis
    Mario Noti
    Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA
    Nat Med 19:1005-13. 2013
  6. pmc Thymic stromal lymphopoietin-mediated extramedullary hematopoiesis promotes allergic inflammation
    Mark C Siracusa
    Department of Microbiology, Institute for Immunology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
    Immunity 39:1158-70. 2013
  7. ncbi request reprint Treatment of eosinophilic esophagitis with specific food elimination diet directed by a combination of skin prick and patch tests
    Jonathan M Spergel
    Division of Allergy and Immunology, The Children s Hospital of Philadelphia, Pennsylvania 19104 4399, USA
    Ann Allergy Asthma Immunol 95:336-43. 2005
  8. pmc The link between allergies and eosinophilic esophagitis: implications for management strategies
    Terri F Brown-Whitehorn
    Division of Allergy and Immunology, The Children s Hospital of Philadelphia, Department of Pediatrics, University of Pennsylvania School of Medicine, 3550 Market Street, Philadelphia, PA 19104, USA
    Expert Rev Clin Immunol 6:101-9. 2010
  9. ncbi request reprint Predictive values for food challenge-induced severe reactions: development of a simple food challenge score
    Antonella Cianferoni
    Department of Pediatrics, Division of Allergy and Immunology, Children s Hospital of Philadelphia, Philadelphia, PA, USA
    Isr Med Assoc J 14:24-8. 2012
  10. doi request reprint Association of eosinophilic gastrointestinal disorders with other atopic disorders
    Soma Jyonouchi
    Division of Allergy and Immunology, The Children s Hospital of Philadelphia, University of Pennsylvania School of Medicine, 34th Street and Civic Center Boulevard, Philadelphia, PA 19104, USA
    Immunol Allergy Clin North Am 29:85-97, x. 2009

Detail Information

Publications53

  1. ncbi request reprint The use of patch testing in the diagnosis of food allergy
    Jonathan M Spergel
    Allergy Section, Division of Allergy and Immunology, The Children s Hospital of Philadelphia, 34th Street and Civic Center Boulevard, Wood 5, Philadelphia, PA 19104, USA
    Curr Allergy Asthma Rep 5:86-90. 2005
    ..In this article, we review literature regarding patch testing: its methods, its statistical usefulness, and its potential future role...
  2. ncbi request reprint Eosinophilic esophagitis in adults and children: evidence for a food allergy component in many patients
    Jonathan M Spergel
    Division of Allergy and Immunology, Children s Hospital of Philadelphia, University of Pennsylvania School of Medicine, 34 and Civic Center Boulevard, Philadelphia, PA 19104, USA
    Curr Opin Allergy Clin Immunol 7:274-8. 2007
    ..This article reviews all literature published in English from December 2005 to November 2006 from PubMed on the topic of eosinophilic esophagitis...
  3. doi request reprint 14 years of eosinophilic esophagitis: clinical features and prognosis
    Jonathan M Spergel
    Division of Allergy and Immunology, The Children s Hospital of Philadelphia, USA
    J Pediatr Gastroenterol Nutr 48:30-6. 2009
    ..To determine the natural history of treated and untreated eosinophilic esophagitis (EE) and examine the presenting symptoms of EE...
  4. doi request reprint Identification of causative foods in children with eosinophilic esophagitis treated with an elimination diet
    Jonathan M Spergel
    Division of Allergy and Immunology, Children s Hospital of Philadelphia, Philadelphia, PA 19104 4399, USA
    J Allergy Clin Immunol 130:461-7.e5. 2012
    ..Eosinophilic esophagitis (EoE) is a chronic inflammatory disease with isolated eosinophils in the esophagus predominantly triggered by foods. The optimal testing to identify inciting foods remains unclear...
  5. pmc Thymic stromal lymphopoietin-elicited basophil responses promote eosinophilic esophagitis
    Mario Noti
    Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA
    Nat Med 19:1005-13. 2013
    ..Together, these data suggest that the TSLP-basophil axis contributes to the pathogenesis of EoE and could be therapeutically targeted to treat this disease. ..
  6. pmc Thymic stromal lymphopoietin-mediated extramedullary hematopoiesis promotes allergic inflammation
    Mark C Siracusa
    Department of Microbiology, Institute for Immunology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
    Immunity 39:1158-70. 2013
    ..These data identify that TSLP-induced EMH contributes to the development of allergic inflammation and indicate that EMH is a conserved mechanism of innate immunity. ..
  7. ncbi request reprint Treatment of eosinophilic esophagitis with specific food elimination diet directed by a combination of skin prick and patch tests
    Jonathan M Spergel
    Division of Allergy and Immunology, The Children s Hospital of Philadelphia, Pennsylvania 19104 4399, USA
    Ann Allergy Asthma Immunol 95:336-43. 2005
    ..Therapies have included corticosteroids, elemental diet, and diet restriction. We report our experience with skin prick and atopy patch testing and food elimination diets in patients diagnosed as having EE...
  8. pmc The link between allergies and eosinophilic esophagitis: implications for management strategies
    Terri F Brown-Whitehorn
    Division of Allergy and Immunology, The Children s Hospital of Philadelphia, Department of Pediatrics, University of Pennsylvania School of Medicine, 3550 Market Street, Philadelphia, PA 19104, USA
    Expert Rev Clin Immunol 6:101-9. 2010
    ..However, differences do exist between the diseases in treatment and pathogenesis. For EE, there are two basic treatment options: avoidance of the food triggers or treatment of the eosinophilic inflammation with corticosteroids...
  9. ncbi request reprint Predictive values for food challenge-induced severe reactions: development of a simple food challenge score
    Antonella Cianferoni
    Department of Pediatrics, Division of Allergy and Immunology, Children s Hospital of Philadelphia, Philadelphia, PA, USA
    Isr Med Assoc J 14:24-8. 2012
    ..Skin-prick tests (SPT), food-specific immunoglobulin E level (sIgE) and clinical history have limited value individually in predicting the severity of outcome of the oral food challenge (OFC)...
  10. doi request reprint Association of eosinophilic gastrointestinal disorders with other atopic disorders
    Soma Jyonouchi
    Division of Allergy and Immunology, The Children s Hospital of Philadelphia, University of Pennsylvania School of Medicine, 34th Street and Civic Center Boulevard, Philadelphia, PA 19104, USA
    Immunol Allergy Clin North Am 29:85-97, x. 2009
    ..Finally, most patients who have eosinophilic gastrointestinal disorders have an associated atopic disease...
  11. pmc Basophils and allergic inflammation
    Mark C Siracusa
    Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pa Institute for Immunology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA
    J Allergy Clin Immunol 132:789-801; quiz 788. 2013
    ..Finally, we discuss the therapeutic potential of targeting basophils in preventing or alleviating the development and progression of allergic inflammation. ..
  12. doi request reprint Biphasic reactions in children undergoing oral food challenges
    JuHee Lee
    Division of Allergy and Immunology, Children s Hospital of Philadelphia, Perelman School of Medicine at University of Pennsylvania, Philadelphia, PA 19104, USA
    Allergy Asthma Proc 34:220-6. 2013
    ..Biphasic reactions are rare in children undergoing OFCs and may be associated with more severe allergic reactions. Children with severe reactions may benefit from a 24-hour period of observation...
  13. doi request reprint Reslizumab in children and adolescents with eosinophilic esophagitis: results of a double-blind, randomized, placebo-controlled trial
    Jonathan M Spergel
    Division of Allergy and Immunology, Department of Pediatrics, Children s Hospital of Philadelphia, Philadelphia, PA 19104, USA
    J Allergy Clin Immunol 129:456-63, 463.e1-3. 2012
    ..Eosinophilic esophagitis is a chronic allergic disease with insufficient treatment options. Results from animal studies suggest that IL-5 induces eosinophil trafficking in the esophagus...
  14. doi request reprint From atopic dermatitis to asthma: the atopic march
    Jonathan M Spergel
    Division of Allergy and Immunology, The Children s Hospital of Philadelphia, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104 4399, USA
    Ann Allergy Asthma Immunol 105:99-106; quiz 107-9, 117. 2010
    ..To examine the mechanisms whereby allergen exposure through the epidermis could initiate systemic allergy and predispose individuals to the development of 1 or more atopic diseases via the so-called atopic march...
  15. pmc Common variants at 5q22 associate with pediatric eosinophilic esophagitis
    Marc E Rothenberg
    Division of Allergy and Immunology, Department of Pediatrics, Cincinnati Children s Hospital Medical Center, University of Cincinnati, Cincinnati, Ohio, USA
    Nat Genet 42:289-91. 2010
    ..These data implicate the 5q22 locus in the pathogenesis of EoE and identify TSLP as the most likely candidate gene in the region...
  16. ncbi request reprint Eosinophilic esophagitis: a 10-year experience in 381 children
    Chris A Liacouras
    Division of Gastroenterology and Nutrition, The Children s Hospital of Philadelphia, Philadelphia, Pennsylvania 19104, USA
    Clin Gastroenterol Hepatol 3:1198-206. 2005
    ..We present information relating to our 10-year experience in children diagnosed with EoE...
  17. doi request reprint Food allergy: review, classification and diagnosis
    Antonella Cianferoni
    Division of Allergy and Immunology, Department of Pediatrics, The Children s Hospital of Philadelphia, University of Pennsylvania School of Medicine, Philadelphia 19104, USA
    Allergol Int 58:457-66. 2009
    ..However, novel strategies are being studied, including sublingual/oral immunotherapy and others with a hope for future...
  18. ncbi request reprint Atopy patch test for the diagnosis of food protein-induced enterocolitis syndrome
    Matthew I Fogg
    Division of Allergy and Immunology, Children s Hospital of Philadelphia, PA 19104, USA
    Pediatr Allergy Immunol 17:351-5. 2006
    ..All 12 patients with a negative APT had a negative oral food challenge to the suspected food. APT appears to be a promising diagnostic tool for the diagnosis of FPIES...
  19. pmc Exposure to food allergens through inflamed skin promotes intestinal food allergy through the thymic stromal lymphopoietin-basophil axis
    Mario Noti
    Department of Microbiology, University of Pennsylvania, Philadelphia, Pa Institute for Immunology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA Division of Experimental Pathology, Institute of Pathology, University of Bern, Bern, Switzerland
    J Allergy Clin Immunol 133:1390-1399.e6. 2014
    ..Exposure to food allergens through a disrupted skin barrier has been recognized as a potential factor in the increasing prevalence of food allergy...
  20. doi request reprint Relating microarray component testing and reported food allergy and food-triggered atopic dermatitis: a real-world analysis
    Irene Fung
    Division of Allergy and Immunology, Children s Hospital of Philadelphia, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
    Ann Allergy Asthma Immunol 110:173-177.e1. 2013
    ..High epitope diversity has been associated with increased IgE-mediated food allergy severity...
  21. pmc Invariant natural killer T cells from children with versus without food allergy exhibit differential responsiveness to milk-derived sphingomyelin
    Soma Jyonouchi
    Division of Allergy and Immunology, The Children s Hospital of Philadelphia, Philadelphia, PA 19104, USA
    J Allergy Clin Immunol 128:102-109.e13. 2011
    ..Major food allergens (eg, milk, egg) are the richest dietary source of sphingolipids (food-derived sphingolipids [food-SLs]). Nonetheless, the role of iNKTs in FA is unknown...
  22. ncbi request reprint Food Intolerance and childhood asthma: what is the link?
    Janet L Beausoleil
    Division of Allergy and Immunology, The Children s Hospital of Philadelphia, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    Paediatr Drugs 9:157-63. 2007
    ..However, similar to skin testing and the RAST, there is good sensitivity but poor specificity, such that specific challenges are often warranted...
  23. pmc Nonimmunoglobulin e-mediated immune reactions to foods
    Jonathan M Spergel
    Assistant Professor of Pediatrics, Division of Allergy and Immunology, Department of Pediatrics, The Children s Hospital of Philadelphia, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania
    Allergy Asthma Clin Immunol 2:78-85. 2006
    ..The most recent evidence suggests that these reactions are probably T-cell mediated as evidenced in lymphocyte proliferation assays. This review will explore the symptoms and testing methods of the most common non-IgE-mediated reactions...
  24. pmc New genetic links in eosinophilic esophagitis
    Jonathan M Spergel
    Division of Allergy and Immunology, Department of Pediatrics, The Children s Hospital of Philadelphia, University of Pennsylvania School of Medicine, 3550 Market Street, Philadelphia, PA 19104, USA
    Genome Med 2:60. 2010
    ..Identification of this molecule and its receptor suggest the potential for new treatment options in the future...
  25. ncbi request reprint Food allergy. Mechanisms, diagnosis, and management in children
    Jonathan M Spergel
    Allergy Section, Division of Immunologic and Infectious Diseases, Children s Hospital of Philadelphia, USA
    Pediatr Clin North Am 49:73-96, vi. 2002
    ..Many people believe that they have an allergic reaction to foods; however, the actual incidence confirmed by history and challenges suggests a prevalence rate closer to 2% to 8% in young infants and less than 2% in adults...
  26. pmc Esophageal epithelial and mesenchymal cross-talk leads to features of epithelial to mesenchymal transition in vitro
    Amanda B Muir
    Divisions of Gastroenterology, Hepatology, and Nutrition, The Children s Hospital of Philadelphia, 34th and Civic Center Blvd, Philadelphia, PA 19104, USA
    Exp Cell Res 319:850-9. 2013
    ..Herein, we investigated consequences of cross-talk between esophageal epithelial cells and fibroblasts, and identified profibrotic cytokines which influence the development of EMT in vitro...
  27. doi request reprint Filaggrin mutations and atopy: consequences for future therapeutics
    Jennifer Heimall
    The Children s Hospital of Philadelphia, Division of Allergy and Immunology, 550 Market Street, PA 19104, USA
    Expert Rev Clin Immunol 8:189-97. 2012
    ..It is on this foundation that therapies aimed at restoration of barrier function are thought to play a role, not only in the effective treatment of atopic eczema, but also in the prevention of further allergic disease development...
  28. pmc TSLP promotes interleukin-3-independent basophil haematopoiesis and type 2 inflammation
    Mark C Siracusa
    Institute for Immunology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Nature 477:229-33. 2011
    ....
  29. ncbi request reprint Correlation of initial food reactions to observed reactions on challenges
    Jonathan M Spergel
    Division of Allergy and Immunology, The Children s Hospital of Philadelphia, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Ann Allergy Asthma Immunol 92:217-24. 2004
    ..These reactions can vary from mild cutaneous manifestations to severe life-threatening reactions. Limited information is available on which specific factors may predict the severity of subsequent reactions...
  30. ncbi request reprint Food allergy and additives: triggers in asthma
    Jonathan M Spergel
    Department of Pediatrics, Division of Allergy and Immunology, The Children s Hospital of Philadelphia, University of Pennsylvania School of Medicine, 34th Sreet and Civic Center Blvd, Philadelphia, PA 19104, USA
    Immunol Allergy Clin North Am 25:149-67. 2005
    ..Susceptible patients may even react to a causative food on inhalation without ingestion. However, isolated asthma or rhinitis symptoms without concomitant cutaneous or gastrointestinal symptoms are rare events...
  31. ncbi request reprint Late diagnosis of tree nut and sesame allergy in patients previously sensitized but tolerant to peanut
    Janet L Beausoleil
    Division of Allergy and Immunology, The Children s Hospital of Philadelphia, Philadelphia, Pennsylvania 19104, USA
    Ann Allergy Asthma Immunol 97:443-5. 2006
    ..Although the coexistence may be simply due to a predisposition to food allergy in these individuals, cross-reactivity has been demonstrated between peanut and tree nuts and between peanut and sesame seed...
  32. doi request reprint Otolaryngologists may not be doing enough to diagnose pediatric eosinophilic esophagitis
    Lee P Smith
    Division of Pediatric Otolaryngology, The Children s Hospital of Philadelphia, Philadelphia, PA 19104 4399, USA
    Int J Pediatr Otorhinolaryngol 73:1554-7. 2009
    ..To systematically evaluate the diagnosis of eosinophilic esophagitis (EE)...
  33. ncbi request reprint Nutritional management of eosinophilic esophagitis
    Jonathan M Spergel
    Division of Allergy and Immunology, Wood Building 5314, The Children s Hospital of Philadelphia, 34th and Civic Center Boulevard, Philadelphia, PA 19104, USA
    Gastrointest Endosc Clin N Am 18:179-94; xi. 2008
    ..This article discusses the nutritional risks and benefits of each approach...
  34. ncbi request reprint Elemental diet is an effective treatment for eosinophilic esophagitis in children and adolescents
    Jonathan E Markowitz
    Divisions of Gastroenterology and Nutrition, The Children s Hospital of Philadelphia, Philadelphia, Pennsylvania 19104, USA
    Am J Gastroenterol 98:777-82. 2003
    ..Corticosteroids, cromolyn, and elemental diet have all been reported as successful treatments for EoE. In this study, we sought to accurately define a population of patients with EoE and then assess their response to elemental diet...
  35. ncbi request reprint The use of skin prick tests and patch tests to identify causative foods in eosinophilic esophagitis
    Jonathan M Spergel
    Allergy Section, Division of Immunologic and Infectious Disease, The Children s Hospital of Philadelphia, PA 19104, USA
    J Allergy Clin Immunol 109:363-8. 2002
    ..The symptoms do not improve on aggressive acid blockade but do improve on elimination diet or corticosteroid treatment, which tentatively links food allergies to this disorder...
  36. doi request reprint Asthma and frequency of wheeze: risk factors for the persistence of atopic dermatitis in children
    Jackie P D Garrett
    Department of Pediatrics, Division of Allergy and Immunology, The Children s Hospital of Philadelphia, Perelman School of Medicine at University of Pennsylvania, Philadelphia, PA 19104, USA
    Ann Allergy Asthma Immunol 110:146-9. 2013
    ....
  37. ncbi request reprint Atopic march: link to upper airways
    Jonathan M Spergel
    Division of Allergy and Immunology, Department of Pediatrics, The Children s Hospital of Philadelphia, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
    Curr Opin Allergy Clin Immunol 5:17-21. 2005
    ..Evidence examining the theory that allergic rhinitis precedes asthma will be discussed. In addition, the role of allergic rhinitis as an end point in the atopic march will be reviewed...
  38. doi request reprint A case-control study of sociodemographic and geographic characteristics of 335 children with eosinophilic esophagitis
    James P Franciosi
    Division of Gastroenterology, Hepatology and Nutrition, The Children s Hospital of Philadelphia, Philadelphia, Pennsylvania, USA
    Clin Gastroenterol Hepatol 7:415-9. 2009
    ..The epidemiology of pediatric eosinophilic esophagitis (EE) is poorly characterized. In this study, we aimed to determine demographic, socioeconomic, and geographic characteristics of our cohort of EE children...
  39. ncbi request reprint Correlation of exhaled nitric oxide, spirometry and asthma symptoms
    Jonathan M Spergel
    Allergy Section, Division of Allergy and Immunology, The Children s Hospital of Philadelphia, Philadelphia, PA 19104, USA
    J Asthma 42:879-83. 2005
    ..FeNO had a strong correlation than FEV1. FeNO and FEV1 were not correlated. We propose that FeNO should be used as an additional monitoring tool for asthma...
  40. ncbi request reprint Management of food allergies
    Matthew I Fogg
    Division of Allergy and Immunology, The Children s Hospital of Philadelphia, University of Pennsylvania School of Medicine, 34th Street and Civic Center Blvd, Philadelphia, PA 19104, USA
    Expert Opin Pharmacother 4:1025-37. 2003
    ..The management of food allergy will also be discussed with particular emphasis on the avoidance of food allergens and the pharmacotherapy of allergic reactions. Future therapy for food allergies will also be discussed...
  41. ncbi request reprint Epidemiology of atopic dermatitis and atopic march in children
    Jonathan M Spergel
    Division of Allergy and Immunology, The Children s Hospital of Philadelphia, University of Pennsylvania School of Medicine, 3550 Market Street, Philadelphia, PA 19104, USA
    Immunol Allergy Clin North Am 30:269-80. 2010
    ..Patients with atopic sensitization along with eczema are at a higher risk for progressing in the atopic march to asthma. The main risk factors for progression and persistence of asthma are early onset and severity of AD...
  42. ncbi request reprint Atopic dermatitis and the atopic march
    Jonathan M Spergel
    Division of Allergy and Immunology, The Children s Hospital of Philadelphia, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
    J Allergy Clin Immunol 112:S118-27. 2003
    ..Animal models and human observation concur with this theory. Preliminary prevention studies with oral antihistamines provide evidence that early intervention might slow the atopic march...
  43. doi request reprint Variation in prevalence, diagnostic criteria, and initial management options for eosinophilic gastrointestinal diseases in the United States
    Jonathan M Spergel
    Division of Allergy and Immunology, Department of Pediatrics, The Children s Hospital of Philadelphia, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    J Pediatr Gastroenterol Nutr 52:300-6. 2011
    ..The aim of the present study was to define the regional and national prevalence of eosinophilic gastrointestinal diseases, and differences in practice approaches...
  44. ncbi request reprint Immunotherapeutic approaches for the treatment of eosinophilic esophagitis
    Antonella Cianferoni
    Divisions of Allergy and Immunology, Department of Pediatrics, The Children s Hospital of Philadelphia, Perelman School of Medicine, University of Pennsylvania, Philadelphia, ARC 1216H, 3615 Civic Center Blvd, Philadelphia, PA 19104, USA
    Immunotherapy 6:321-31. 2014
    ..In this review, we review standard and immunotherapeutic options for EoE treatment, such as anti-IL-5, anti-TNF╬▒, anti-IgE, anti-CRTH, oral allergy desensitization and environmental immunotherapy. ..
  45. doi request reprint Eosinophilic esophagitis: updated consensus recommendations for children and adults
    Chris A Liacouras
    Center for Pediatric Eosinophilic Disorders, Division of Gastroenterology, Hepatology, and Nutrition, The Children s Hospital of Philadelphia, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
    J Allergy Clin Immunol 128:3-20.e6; quiz 21-2. 2011
    ..Further advances and controversies regarding diagnostic methods, surrogate disease markers, allergy testing, and treatment approaches are discussed...
  46. doi request reprint Variants of DENND1B associated with asthma in children
    Patrick M A Sleiman
    Center for Applied Genomics, Philadelphia, PA 19104 4318, USA
    N Engl J Med 362:36-44. 2010
    ..Asthma is a complex disease that has genetic and environmental causes. The genetic factors associated with susceptibility to asthma remain largely unknown...
  47. ncbi request reprint Immunology and treatment of atopic dermatitis
    Jonathan M Spergel
    Allergy Section, Division of Allergy and Immunology, The Children s Hospital of Philadelphia, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 4399, USA
    Am J Clin Dermatol 9:233-44. 2008
    ..Together, TCSs and TCIs represent the backbone of a long-term treatment strategy for AD...
  48. ncbi request reprint Effect of topical pimecrolimus on epicutaneous skin testing
    Jonathan M Spergel
    J Allergy Clin Immunol 114:695-7. 2004
  49. ncbi request reprint Safety of topical calcineurin inhibitors in atopic dermatitis: evaluation of the evidence
    Jonathan M Spergel
    Curr Allergy Asthma Rep 6:270-4. 2006
    ..To date, studies from clinical trials, systemic absorption, and post-marketing surveillance show no evidence for this systemic immunosuppression or increased risk for any malignancy...
  50. ncbi request reprint Pollen and eosinophilic esophagitis
    Matthew I Fogg
    J Allergy Clin Immunol 112:796-7. 2003
  51. ncbi request reprint Authors' response to detection of causative foods by skin prick and atopy patch tests in patients with eosinophilic esophagitis: things are not what they seem
    Jonathan M Spergel
    Ann Allergy Asthma Immunol 96:376-8. 2006
  52. ncbi request reprint Predictive values for skin prick test and atopy patch test for eosinophilic esophagitis
    Jonathan M Spergel
    J Allergy Clin Immunol 119:509-11. 2007
  53. ncbi request reprint The black box warning for topical calcineurin inhibitors: looking outside the box
    Luz Fonacier
    Winthrop University Hospital, State University of New York, Stony Brook School of Medicine, New York, USA
    Ann Allergy Asthma Immunol 97:117-20. 2006