J M Spergel

Summary

Affiliation: The Children's Hospital of Philadelphia
Country: USA

Publications

  1. doi request reprint Identification of causative foods in children with eosinophilic esophagitis treated with an elimination diet
    Jonathan M Spergel
    Division of Allergy and Immunology, Children s Hospital of Philadelphia, Philadelphia, PA 19104 4399, USA
    J Allergy Clin Immunol 130:461-7.e5. 2012
  2. doi request reprint Reslizumab in children and adolescents with eosinophilic esophagitis: results of a double-blind, randomized, placebo-controlled trial
    Jonathan M Spergel
    Division of Allergy and Immunology, Department of Pediatrics, Children s Hospital of Philadelphia, Philadelphia, PA 19104, USA
    J Allergy Clin Immunol 129:456-63, 463.e1-3. 2012
  3. ncbi request reprint Addition of topical pimecrolimus to once-daily mid-potent steroid confers no short-term therapeutic benefit in the treatment of severe atopic dermatitis; a randomized controlled trial
    J M Spergel
    Division of Allergy and Immunology, Children s Hospital of Philadelphia, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
    Br J Dermatol 157:378-81. 2007
  4. ncbi request reprint Food allergy and additives: triggers in asthma
    Jonathan M Spergel
    Department of Pediatrics, Division of Allergy and Immunology, The Children s Hospital of Philadelphia, University of Pennsylvania School of Medicine, 34th Sreet and Civic Center Blvd, Philadelphia, PA 19104, USA
    Immunol Allergy Clin North Am 25:149-67. 2005
  5. ncbi request reprint Atopic march: link to upper airways
    Jonathan M Spergel
    Division of Allergy and Immunology, Department of Pediatrics, The Children s Hospital of Philadelphia, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
    Curr Opin Allergy Clin Immunol 5:17-21. 2005
  6. ncbi request reprint The use of patch testing in the diagnosis of food allergy
    Jonathan M Spergel
    Allergy Section, Division of Allergy and Immunology, The Children s Hospital of Philadelphia, 34th Street and Civic Center Boulevard, Wood 5, Philadelphia, PA 19104, USA
    Curr Allergy Asthma Rep 5:86-90. 2005
  7. pmc Nonimmunoglobulin e-mediated immune reactions to foods
    Jonathan M Spergel
    Assistant Professor of Pediatrics, Division of Allergy and Immunology, Department of Pediatrics, The Children s Hospital of Philadelphia, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania
    Allergy Asthma Clin Immunol 2:78-85. 2006
  8. ncbi request reprint Treatment of eosinophilic esophagitis with specific food elimination diet directed by a combination of skin prick and patch tests
    Jonathan M Spergel
    Division of Allergy and Immunology, The Children s Hospital of Philadelphia, Pennsylvania 19104 4399, USA
    Ann Allergy Asthma Immunol 95:336-43. 2005
  9. doi request reprint 14 years of eosinophilic esophagitis: clinical features and prognosis
    Jonathan M Spergel
    Division of Allergy and Immunology, The Children s Hospital of Philadelphia, USA
    J Pediatr Gastroenterol Nutr 48:30-6. 2009
  10. ncbi request reprint Immunology and treatment of atopic dermatitis
    Jonathan M Spergel
    Allergy Section, Division of Allergy and Immunology, The Children s Hospital of Philadelphia, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 4399, USA
    Am J Clin Dermatol 9:233-44. 2008

Research Grants

  1. Pimecrolius on T cell Responses in Atopic March
    Jonathan Spergel; Fiscal Year: 2007

Detail Information

Publications39

  1. doi request reprint Identification of causative foods in children with eosinophilic esophagitis treated with an elimination diet
    Jonathan M Spergel
    Division of Allergy and Immunology, Children s Hospital of Philadelphia, Philadelphia, PA 19104 4399, USA
    J Allergy Clin Immunol 130:461-7.e5. 2012
    ..Eosinophilic esophagitis (EoE) is a chronic inflammatory disease with isolated eosinophils in the esophagus predominantly triggered by foods. The optimal testing to identify inciting foods remains unclear...
  2. doi request reprint Reslizumab in children and adolescents with eosinophilic esophagitis: results of a double-blind, randomized, placebo-controlled trial
    Jonathan M Spergel
    Division of Allergy and Immunology, Department of Pediatrics, Children s Hospital of Philadelphia, Philadelphia, PA 19104, USA
    J Allergy Clin Immunol 129:456-63, 463.e1-3. 2012
    ..Eosinophilic esophagitis is a chronic allergic disease with insufficient treatment options. Results from animal studies suggest that IL-5 induces eosinophil trafficking in the esophagus...
  3. ncbi request reprint Addition of topical pimecrolimus to once-daily mid-potent steroid confers no short-term therapeutic benefit in the treatment of severe atopic dermatitis; a randomized controlled trial
    J M Spergel
    Division of Allergy and Immunology, Children s Hospital of Philadelphia, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
    Br J Dermatol 157:378-81. 2007
    ..05% (FP), a mid-potency topical corticosteroid, may have a synergistic effect for treatment of atopic dermatitis (AD) because their mechanism of action differs...
  4. ncbi request reprint Food allergy and additives: triggers in asthma
    Jonathan M Spergel
    Department of Pediatrics, Division of Allergy and Immunology, The Children s Hospital of Philadelphia, University of Pennsylvania School of Medicine, 34th Sreet and Civic Center Blvd, Philadelphia, PA 19104, USA
    Immunol Allergy Clin North Am 25:149-67. 2005
    ..Susceptible patients may even react to a causative food on inhalation without ingestion. However, isolated asthma or rhinitis symptoms without concomitant cutaneous or gastrointestinal symptoms are rare events...
  5. ncbi request reprint Atopic march: link to upper airways
    Jonathan M Spergel
    Division of Allergy and Immunology, Department of Pediatrics, The Children s Hospital of Philadelphia, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
    Curr Opin Allergy Clin Immunol 5:17-21. 2005
    ..Evidence examining the theory that allergic rhinitis precedes asthma will be discussed. In addition, the role of allergic rhinitis as an end point in the atopic march will be reviewed...
  6. ncbi request reprint The use of patch testing in the diagnosis of food allergy
    Jonathan M Spergel
    Allergy Section, Division of Allergy and Immunology, The Children s Hospital of Philadelphia, 34th Street and Civic Center Boulevard, Wood 5, Philadelphia, PA 19104, USA
    Curr Allergy Asthma Rep 5:86-90. 2005
    ..In this article, we review literature regarding patch testing: its methods, its statistical usefulness, and its potential future role...
  7. pmc Nonimmunoglobulin e-mediated immune reactions to foods
    Jonathan M Spergel
    Assistant Professor of Pediatrics, Division of Allergy and Immunology, Department of Pediatrics, The Children s Hospital of Philadelphia, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania
    Allergy Asthma Clin Immunol 2:78-85. 2006
    ..The most recent evidence suggests that these reactions are probably T-cell mediated as evidenced in lymphocyte proliferation assays. This review will explore the symptoms and testing methods of the most common non-IgE-mediated reactions...
  8. ncbi request reprint Treatment of eosinophilic esophagitis with specific food elimination diet directed by a combination of skin prick and patch tests
    Jonathan M Spergel
    Division of Allergy and Immunology, The Children s Hospital of Philadelphia, Pennsylvania 19104 4399, USA
    Ann Allergy Asthma Immunol 95:336-43. 2005
    ..Therapies have included corticosteroids, elemental diet, and diet restriction. We report our experience with skin prick and atopy patch testing and food elimination diets in patients diagnosed as having EE...
  9. doi request reprint 14 years of eosinophilic esophagitis: clinical features and prognosis
    Jonathan M Spergel
    Division of Allergy and Immunology, The Children s Hospital of Philadelphia, USA
    J Pediatr Gastroenterol Nutr 48:30-6. 2009
    ..To determine the natural history of treated and untreated eosinophilic esophagitis (EE) and examine the presenting symptoms of EE...
  10. ncbi request reprint Immunology and treatment of atopic dermatitis
    Jonathan M Spergel
    Allergy Section, Division of Allergy and Immunology, The Children s Hospital of Philadelphia, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 4399, USA
    Am J Clin Dermatol 9:233-44. 2008
    ..Together, TCSs and TCIs represent the backbone of a long-term treatment strategy for AD...
  11. doi request reprint Epidemiology of atopic dermatitis and atopic march in children
    Jonathan M Spergel
    Division of Allergy and Immunology, The Children s Hospital of Philadelphia, University of Pennsylvania School of Medicine, 3550 Market Street, Philadelphia, PA 19104, USA
    Immunol Allergy Clin North Am 30:269-80. 2010
    ..Patients with atopic sensitization along with eczema are at a higher risk for progressing in the atopic march to asthma. The main risk factors for progression and persistence of asthma are early onset and severity of AD...
  12. ncbi request reprint Correlation of initial food reactions to observed reactions on challenges
    Jonathan M Spergel
    Division of Allergy and Immunology, The Children s Hospital of Philadelphia, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Ann Allergy Asthma Immunol 92:217-24. 2004
    ..These reactions can vary from mild cutaneous manifestations to severe life-threatening reactions. Limited information is available on which specific factors may predict the severity of subsequent reactions...
  13. doi request reprint From atopic dermatitis to asthma: the atopic march
    Jonathan M Spergel
    Division of Allergy and Immunology, The Children s Hospital of Philadelphia, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104 4399, USA
    Ann Allergy Asthma Immunol 105:99-106; quiz 107-9, 117. 2010
    ..To examine the mechanisms whereby allergen exposure through the epidermis could initiate systemic allergy and predispose individuals to the development of 1 or more atopic diseases via the so-called atopic march...
  14. pmc New genetic links in eosinophilic esophagitis
    Jonathan M Spergel
    Division of Allergy and Immunology, Department of Pediatrics, The Children s Hospital of Philadelphia, University of Pennsylvania School of Medicine, 3550 Market Street, Philadelphia, PA 19104, USA
    Genome Med 2:60. 2010
    ..Identification of this molecule and its receptor suggest the potential for new treatment options in the future...
  15. ncbi request reprint Nutritional management of eosinophilic esophagitis
    Jonathan M Spergel
    Division of Allergy and Immunology, Wood Building 5314, The Children s Hospital of Philadelphia, 34th and Civic Center Boulevard, Philadelphia, PA 19104, USA
    Gastrointest Endosc Clin N Am 18:179-94; xi. 2008
    ..This article discusses the nutritional risks and benefits of each approach...
  16. doi request reprint Variation in prevalence, diagnostic criteria, and initial management options for eosinophilic gastrointestinal diseases in the United States
    Jonathan M Spergel
    Division of Allergy and Immunology, Department of Pediatrics, The Children s Hospital of Philadelphia, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    J Pediatr Gastroenterol Nutr 52:300-6. 2011
    ..The aim of the present study was to define the regional and national prevalence of eosinophilic gastrointestinal diseases, and differences in practice approaches...
  17. ncbi request reprint Food allergy. Mechanisms, diagnosis, and management in children
    Jonathan M Spergel
    Allergy Section, Division of Immunologic and Infectious Diseases, Children s Hospital of Philadelphia, USA
    Pediatr Clin North Am 49:73-96, vi. 2002
    ..Many people believe that they have an allergic reaction to foods; however, the actual incidence confirmed by history and challenges suggests a prevalence rate closer to 2% to 8% in young infants and less than 2% in adults...
  18. ncbi request reprint Natural history of peanut allergy
    J M Spergel
    Allergy Section, Division of Immunologic and Infectious Diseases, The Children s Hospital of Philadelphia, Philadelphia, Pennsylvania 19104, USA
    Curr Opin Pediatr 13:517-22. 2001
    ..The effects of cooking and altering peanut allergens are discussed as are potential treatment modalities...
  19. ncbi request reprint Correlation of exhaled nitric oxide, spirometry and asthma symptoms
    Jonathan M Spergel
    Allergy Section, Division of Allergy and Immunology, The Children s Hospital of Philadelphia, Philadelphia, PA 19104, USA
    J Asthma 42:879-83. 2005
    ..FeNO had a strong correlation than FEV1. FeNO and FEV1 were not correlated. We propose that FeNO should be used as an additional monitoring tool for asthma...
  20. ncbi request reprint Food allergy presenting as a "septic"-appearing infant
    Timothy Andrews
    Division of Allergy and Immunology, The Children s Hospital of Philadelphia, Philadelphia, PA 19104 4399, USA
    Pediatr Emerg Care 20:677-9. 2004
  21. ncbi request reprint The Illness Management Survey: identifying adolescents' perceptions of barriers to adherence
    Deirdre Logan
    Department of Psychology, The Children s Hospital of Philadelphia, PA 19104, USA
    J Pediatr Psychol 28:383-92. 2003
    ..To develop a self-report measure of barriers to adherence and to evaluate its reliability and validity in a sample of adolescents with asthma...
  22. doi request reprint The natural history of eosinophilic oesophagitis in the transition from childhood to adulthood
    P Menard-Katcher
    Division of Gastroenterology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, USA
    Aliment Pharmacol Ther 37:114-21. 2013
    ..Eosinophilic oesophagitis (EoE) is a chronic inflammatory condition affecting both children and adults. Little is known about the natural history of EoE in the transition from childhood into adulthood...
  23. ncbi request reprint Anaphylaxis to raw potato
    J L Beausoleil
    Division of Immunologic and Infectious Diseases, The Children's Hospital of Philadelphia, PA 19104, USA
    Ann Allergy Asthma Immunol 86:68-70. 2001
    ..CONCLUSIONS: This patient had clinical and skin test reactivity to raw and uncooked potato in the absence of OAS. The patient will be followed for the development of seasonal allergic rhinitis...
  24. ncbi request reprint Eliminating eosinophilic esophagitis
    Jonathan Spergel
    Division of Immunologic, Infectious Disease, The Children s Hospital of Philadelphia, Cincinnati Children s Hospital Medical Center, 34th Street and Civic Center Boulevard, Philadelphia, PA 19104, USA
    Clin Immunol 115:131-2. 2005
  25. ncbi request reprint Authors' response to detection of causative foods by skin prick and atopy patch tests in patients with eosinophilic esophagitis: things are not what they seem
    Jonathan M Spergel
    Ann Allergy Asthma Immunol 96:376-8. 2006
  26. ncbi request reprint The use of skin prick tests and patch tests to identify causative foods in eosinophilic esophagitis
    Jonathan M Spergel
    Allergy Section, Division of Immunologic and Infectious Disease, The Children s Hospital of Philadelphia, PA 19104, USA
    J Allergy Clin Immunol 109:363-8. 2002
    ..The symptoms do not improve on aggressive acid blockade but do improve on elimination diet or corticosteroid treatment, which tentatively links food allergies to this disorder...
  27. ncbi request reprint Elemental diet is an effective treatment for eosinophilic esophagitis in children and adolescents
    Jonathan E Markowitz
    Divisions of Gastroenterology and Nutrition, The Children s Hospital of Philadelphia, Philadelphia, Pennsylvania 19104, USA
    Am J Gastroenterol 98:777-82. 2003
    ..Corticosteroids, cromolyn, and elemental diet have all been reported as successful treatments for EoE. In this study, we sought to accurately define a population of patients with EoE and then assess their response to elemental diet...
  28. ncbi request reprint Management of food allergies
    Matthew I Fogg
    Division of Allergy and Immunology, The Children s Hospital of Philadelphia, University of Pennsylvania School of Medicine, 34th Street and Civic Center Blvd, Philadelphia, PA 19104, USA
    Expert Opin Pharmacother 4:1025-37. 2003
    ..The management of food allergy will also be discussed with particular emphasis on the avoidance of food allergens and the pharmacotherapy of allergic reactions. Future therapy for food allergies will also be discussed...
  29. ncbi request reprint Pollen and eosinophilic esophagitis
    Matthew I Fogg
    J Allergy Clin Immunol 112:796-7. 2003
  30. ncbi request reprint Atopic dermatitis and the atopic march
    Jonathan M Spergel
    Division of Allergy and Immunology, The Children s Hospital of Philadelphia, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
    J Allergy Clin Immunol 112:S118-27. 2003
    ..Animal models and human observation concur with this theory. Preliminary prevention studies with oral antihistamines provide evidence that early intervention might slow the atopic march...
  31. ncbi request reprint Effect of topical pimecrolimus on epicutaneous skin testing
    Jonathan M Spergel
    J Allergy Clin Immunol 114:695-7. 2004
  32. ncbi request reprint Eosinophilic esophagitis: a 10-year experience in 381 children
    Chris A Liacouras
    Division of Gastroenterology and Nutrition, The Children s Hospital of Philadelphia, Philadelphia, Pennsylvania 19104, USA
    Clin Gastroenterol Hepatol 3:1198-206. 2005
    ..We present information relating to our 10-year experience in children diagnosed with EoE...
  33. ncbi request reprint Safety of topical calcineurin inhibitors in atopic dermatitis: evaluation of the evidence
    Jonathan M Spergel
    Curr Allergy Asthma Rep 6:270-4. 2006
    ..To date, studies from clinical trials, systemic absorption, and post-marketing surveillance show no evidence for this systemic immunosuppression or increased risk for any malignancy...
  34. ncbi request reprint Atopy patch test for the diagnosis of food protein-induced enterocolitis syndrome
    Matthew I Fogg
    Division of Allergy and Immunology, Children s Hospital of Philadelphia, PA 19104, USA
    Pediatr Allergy Immunol 17:351-5. 2006
    ..All 12 patients with a negative APT had a negative oral food challenge to the suspected food. APT appears to be a promising diagnostic tool for the diagnosis of FPIES...
  35. ncbi request reprint Eosinophilic esophagitis in adults and children: evidence for a food allergy component in many patients
    Jonathan M Spergel
    Division of Allergy and Immunology, Children s Hospital of Philadelphia, University of Pennsylvania School of Medicine, 34 and Civic Center Boulevard, Philadelphia, PA 19104, USA
    Curr Opin Allergy Clin Immunol 7:274-8. 2007
    ..This article reviews all literature published in English from December 2005 to November 2006 from PubMed on the topic of eosinophilic esophagitis...
  36. ncbi request reprint Predictive values for skin prick test and atopy patch test for eosinophilic esophagitis
    Jonathan M Spergel
    J Allergy Clin Immunol 119:509-11. 2007
  37. ncbi request reprint Late diagnosis of tree nut and sesame allergy in patients previously sensitized but tolerant to peanut
    Janet L Beausoleil
    Division of Allergy and Immunology, The Children s Hospital of Philadelphia, Philadelphia, Pennsylvania 19104, USA
    Ann Allergy Asthma Immunol 97:443-5. 2006
    ..Although the coexistence may be simply due to a predisposition to food allergy in these individuals, cross-reactivity has been demonstrated between peanut and tree nuts and between peanut and sesame seed...
  38. ncbi request reprint Food Intolerance and childhood asthma: what is the link?
    Janet L Beausoleil
    Division of Allergy and Immunology, The Children s Hospital of Philadelphia, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    Paediatr Drugs 9:157-63. 2007
    ..However, similar to skin testing and the RAST, there is good sensitivity but poor specificity, such that specific challenges are often warranted...
  39. ncbi request reprint The black box warning for topical calcineurin inhibitors: looking outside the box
    Luz Fonacier
    Winthrop University Hospital, State University of New York, Stony Brook School of Medicine, New York, USA
    Ann Allergy Asthma Immunol 97:117-20. 2006

Research Grants4

  1. Pimecrolius on T cell Responses in Atopic March
    Jonathan Spergel; Fiscal Year: 2007
    ..In third aim of the trial, we explore the effects of pimecrolimus as a disease-modifying agent in the prevention of asthma. Asthma phenotype will be examined by spirometry per and post-beta-2-agonist and exhaled nitric oxide. ..