David E Somers

Summary

Affiliation: The Ohio State University
Country: USA

Publications

  1. ncbi The Arabidopsis clock: time for an about-face?
    David E Somers
    Department of Molecular Genetics, Ohio State University, 244B Rightmire Hall, 1060 Carmack Road, Columbus, OH 43210, USA
    Genome Biol 13:153. 2012
  2. ncbi Clock-associated genes in Arabidopsis: a family affair
    D E Somers
    Department of Plant Biology, Ohio State University, Columbus, OH 43210, USA
    Philos Trans R Soc Lond B Biol Sci 356:1745-53. 2001
  3. ncbi Thinking outside the F-box: novel ligands for novel receptors
    David E Somers
    Department of Plant Cellular and Molecular Biology, The Ohio State University, 054 Rightmire Hall, 1060 Carmack Road, Columbus, OH 43210, USA
    Trends Plant Sci 14:206-13. 2009
  4. ncbi The F-box protein ZEITLUPE confers dosage-dependent control on the circadian clock, photomorphogenesis, and flowering time
    David E Somers
    Department of Plant Biology Plant Biotechnology Center, Ohio State University, Columbus, Ohio 43210, USA
    Plant Cell 16:769-82. 2004
  5. ncbi Post-translational regulation of the Arabidopsis circadian clock through selective proteolysis and phosphorylation of pseudo-response regulator proteins
    Sumire Fujiwara
    Department of Plant Cellular and Molecular Biology, Ohio State University, Columbus, Ohio 43210, USA
    J Biol Chem 283:23073-83. 2008
  6. ncbi Independent roles for EARLY FLOWERING 3 and ZEITLUPE in the control of circadian timing, hypocotyl length, and flowering time
    Woe Yeon Kim
    Department of Plant Cellular and Molecular Biology, Plant Biotechnology Center, Ohio State University, Columbus, OH 43210, USA
    Plant Physiol 139:1557-69. 2005
  7. ncbi ZEITLUPE is a circadian photoreceptor stabilized by GIGANTEA in blue light
    Woe Yeon Kim
    Department of Plant Cellular and Molecular Biology Plant Biotechnology Center, Ohio State University, 054 Rightmire Hall, 1060 Carmack Road, Columbus, Ohio 43210, USA
    Nature 449:356-60. 2007
  8. ncbi Characterization of pseudo-response regulators in plants
    Woe Yeon Kim
    Department of Plant Cellular and Molecular Biology, Ohio State University, Columbus, Ohio, USA
    Methods Enzymol 471:357-78. 2010
  9. ncbi PRR5 regulates phosphorylation, nuclear import and subnuclear localization of TOC1 in the Arabidopsis circadian clock
    Lei Wang
    Department of Plant Cellular and Molecular Biology, Ohio State University, Columbus, OH, USA
    EMBO J 29:1903-15. 2010
  10. ncbi HSP90 functions in the circadian clock through stabilization of the client F-box protein ZEITLUPE
    Tae Sung Kim
    Department of Molecular Genetics, Ohio State University, Columbus, OH 43210, USA
    Proc Natl Acad Sci U S A 108:16843-8. 2011

Research Grants

  1. Post-translational control mechanisms of the circadian clock
    David E Somers; Fiscal Year: 2010

Collaborators

  • Lei Wang
  • Patrice A Salome
  • C Robertson McClung
  • Sang Yeol Lee
  • Jin Ho Park
  • Shigeru Hanano
  • Trudie Allen
  • Paloma Mas
  • Seth J Davis
  • Andrew J Millar
  • Paul F Devlin
  • Woe Yeon Kim
  • Sumire Fujiwara
  • Woe-Yeon Kim
  • Jeongsik Kim
  • Linqu Han
  • Tae Sung Kim
  • Eddy P Risseeuw
  • Jing Bo Jin
  • Sung Suk Suh
  • Sung-Suk Suh
  • Eva Kevei
  • William L Crosby
  • Joon Yung Cha
  • Paul M Hasegawa
  • Dae-Jin Yun
  • Chan Yul Yoo
  • Dae Jin Yun
  • Ilha Lee
  • Ray A Bressan
  • Yin Hua Jin
  • Jiyoung Lee
  • Youbong Hyun
  • Michael Van Oosten
  • Kenji Miura
  • Yumi Kim
  • Karine David
  • Hong Gil Nam
  • Joanna Putterill
  • Megan M Southern
  • Reka Toth
  • Maria E Eriksson
  • Ruth M Bastow
  • Victoria Hibberd
  • Anthony Hall
  • Laszlo Kozma-Bognar
  • Balazs Feher
  • Ferenc Nagy
  • Péter Gyula
  • Andras Viczian
  • Karen A Hicks
  • Mary Mason
  • Timothy E Daskalchuk
  • Travis W Banks
  • Enwu Liu
  • Julian Cotelesage
  • Ruishuang Geng
  • Hanjo Hellmann
  • Mark Estelle

Detail Information

Publications20

  1. ncbi The Arabidopsis clock: time for an about-face?
    David E Somers
    Department of Molecular Genetics, Ohio State University, 244B Rightmire Hall, 1060 Carmack Road, Columbus, OH 43210, USA
    Genome Biol 13:153. 2012
    ..Three recent studies have altered thinking on the role of TIMING OF CAB EXPRESSION 1 (TOC1), a core element in the plant circadian oscillator...
  2. ncbi Clock-associated genes in Arabidopsis: a family affair
    D E Somers
    Department of Plant Biology, Ohio State University, Columbus, OH 43210, USA
    Philos Trans R Soc Lond B Biol Sci 356:1745-53. 2001
    ..When added to the repertoire of previously identified clock-associated genes, it is clear that both similarities and differences with other circadian systems will emerge in the coming years...
  3. ncbi Thinking outside the F-box: novel ligands for novel receptors
    David E Somers
    Department of Plant Cellular and Molecular Biology, The Ohio State University, 054 Rightmire Hall, 1060 Carmack Road, Columbus, OH 43210, USA
    Trends Plant Sci 14:206-13. 2009
    ..If this new connection between ligand-regulated proteolysis and signaling proves to be more extensive, an entirely new way of understanding the control of signal transduction is in the offing...
  4. ncbi The F-box protein ZEITLUPE confers dosage-dependent control on the circadian clock, photomorphogenesis, and flowering time
    David E Somers
    Department of Plant Biology Plant Biotechnology Center, Ohio State University, Columbus, Ohio 43210, USA
    Plant Cell 16:769-82. 2004
    ..We also demonstrate that ZTL-dependent delay of flowering is mediated through decreases in CONSTANS and FLOWERING LOCUS T message levels, thus directly linking proteasome-dependent proteolysis to flowering...
  5. ncbi Post-translational regulation of the Arabidopsis circadian clock through selective proteolysis and phosphorylation of pseudo-response regulator proteins
    Sumire Fujiwara
    Department of Plant Cellular and Molecular Biology, Ohio State University, Columbus, Ohio 43210, USA
    J Biol Chem 283:23073-83. 2008
    ....
  6. ncbi Independent roles for EARLY FLOWERING 3 and ZEITLUPE in the control of circadian timing, hypocotyl length, and flowering time
    Woe Yeon Kim
    Department of Plant Cellular and Molecular Biology, Plant Biotechnology Center, Ohio State University, Columbus, OH 43210, USA
    Plant Physiol 139:1557-69. 2005
    ..These results show that elf3-1 can derepress late flowering through a CO-independent mechanism. ELF3 may act at more than one juncture, possibly posttranscriptionally...
  7. ncbi ZEITLUPE is a circadian photoreceptor stabilized by GIGANTEA in blue light
    Woe Yeon Kim
    Department of Plant Cellular and Molecular Biology Plant Biotechnology Center, Ohio State University, 054 Rightmire Hall, 1060 Carmack Road, Columbus, Ohio 43210, USA
    Nature 449:356-60. 2007
    ..This mechanism of establishing and sustaining robust oscillations of ZTL results in the high-amplitude TOC1 rhythms necessary for proper clock function...
  8. ncbi Characterization of pseudo-response regulators in plants
    Woe Yeon Kim
    Department of Plant Cellular and Molecular Biology, Ohio State University, Columbus, Ohio, USA
    Methods Enzymol 471:357-78. 2010
    ..PRR stability is also tightly controlled. This chapter provides methods for studying both the PRR genes and their encoded proteins...
  9. ncbi PRR5 regulates phosphorylation, nuclear import and subnuclear localization of TOC1 in the Arabidopsis circadian clock
    Lei Wang
    Department of Plant Cellular and Molecular Biology, Ohio State University, Columbus, OH, USA
    EMBO J 29:1903-15. 2010
    ..g. timeless/period and clock/cycle), suggesting evolutionary convergence of a conserved mechanism across kingdoms...
  10. ncbi HSP90 functions in the circadian clock through stabilization of the client F-box protein ZEITLUPE
    Tae Sung Kim
    Department of Molecular Genetics, Ohio State University, Columbus, OH 43210, USA
    Proc Natl Acad Sci U S A 108:16843-8. 2011
    ..Unlike metazoan systems, HSP90 functions here within the core oscillator. Additionally, F-box proteins as clients may place HSP90 in a unique and more central role in proteostasis...
  11. ncbi Transcriptional corepressor TOPLESS complexes with pseudoresponse regulator proteins and histone deacetylases to regulate circadian transcription
    Lei Wang
    Department of Molecular Genetics, Ohio State University, Columbus, OH 43210
    Proc Natl Acad Sci U S A 110:761-6. 2013
    ..Our findings show that the TPL/TPR corepressor family are components of the central circadian oscillator mechanism and reinforces the role of this family as central to multiple signaling pathways in higher plants...
  12. ncbi Formation of an SCF(ZTL) complex is required for proper regulation of circadian timing
    Linqu Han
    Department of Plant Cellular and Molecular Biology, Ohio State University, Columbus, OH, USA
    Plant J 40:291-301. 2004
    ..Taken together, our data establish SCFZTL as an essential SCF class E3 ligase controlling circadian period in plants...
  13. ncbi Circadian phase-specific degradation of the F-box protein ZTL is mediated by the proteasome
    Woe-Yeon Kim
    Department of Plant Biology/Plant Biotechnology Center, Ohio State University, Columbus, OH 43210, USA
    Proc Natl Acad Sci U S A 100:4933-8. 2003
    ..This demonstration of circadian phase-regulated degradation of an F-box protein, which itself controls circadian period, suggests a novel regulatory feedback mechanism among known circadian systems...
  14. ncbi Rapid assessment of gene function in the circadian clock using artificial microRNA in Arabidopsis mesophyll protoplasts
    Jeongsik Kim
    Department of Plant Cellular and Molecular Biology Plant Biotechnology Center, The Ohio State University, Columbus, Ohio 43210, USA
    Plant Physiol 154:611-21. 2010
    ..This approach will be useful in a wide range of plant disciplines when an endogenous cell-based phenotype is observable or can be devised, as done here using a luciferase reporter...
  15. ncbi Posttranslational photomodulation of circadian amplitude
    D E Somers
    Department of Plant Cellular and Molecular Biology, Ohio State University Columbus, Ohio 43210, USA
    Cold Spring Harb Symp Quant Biol 72:193-200. 2007
    ..In the process, the waveform of a core clock component is sharpened or "sculpted," resulting in appropriately high amplitude and proper phasing to obtain normal clock function...
  16. ncbi Arabidopsis FHY3 specifically gates phytochrome signaling to the circadian clock
    Trudie Allen
    Department of Biology, University of Leicester, Leicester LE1 7RH, United Kingdom
    Plant Cell 18:2506-16. 2006
    ..FHY3 appears to be a novel gating factor, specifically in gating red light signaling to the clock during daytime...
  17. ncbi Forward genetic analysis of the circadian clock separates the multiple functions of ZEITLUPE
    Eva Kevei
    Institute of Plant Biology, Biological Research Centre of the Hungarian Academy of Sciences, Szeged
    Plant Physiol 140:933-45. 2006
    ..Forward genetics continues to provide insight regarding both known and newly discovered components of the circadian system, although current approaches have saturated mutations at some loci...
  18. ncbi Targeted degradation of TOC1 by ZTL modulates circadian function in Arabidopsis thaliana
    Paloma Mas
    Department of Cell Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, USA
    Nature 426:567-70. 2003
    ..Our results show that the TOC1-ZTL interaction is important in the control of TOC1 protein stability, and is probably responsible for the regulation of circadian period by the clock...
  19. ncbi The SUMO E3 ligase, AtSIZ1, regulates flowering by controlling a salicylic acid-mediated floral promotion pathway and through affects on FLC chromatin structure
    Jing Bo Jin
    Department of Horticulture and Landscape Architecture, Purdue University, West Lafayette, IN 47907 2010, USA
    Plant J 53:530-40. 2008
    ....
  20. ncbi Protein interaction analysis of SCF ubiquitin E3 ligase subunits from Arabidopsis
    Eddy P Risseeuw
    Gene Expression Group, NRC Plant Biotechnology Institute, 110 Gymnasium Place, Saskatoon, SK, Canada S7N-0W9
    Plant J 34:753-67. 2003
    ..These and related results are discussed in terms of their implications for subunit composition, stoichiometry and functional diversity of SCF complexes in Arabidopsis...

Research Grants1

  1. Post-translational control mechanisms of the circadian clock
    David E Somers; Fiscal Year: 2010
    ..Here post-translational mechanism of circadian clock control in Arabidopsis is investigated, with potential relevance to other eukaryotic oscillatory systems. ..