Research Topics
Species | N SneigeSummaryAffiliation: The University of Texas Country: USA Publications
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Publications
High and differential expression of HER-2/neu extracellular domain in bilateral ductal fluids from women with unilateral invasive breast cancerHenry M Kuerer
Department of Surgical Oncology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
Clin Cancer Res 9:601-5. 2003..Breast ductal fluid can be obtained from women by simple nipple aspiration and may be useful for analyzing the microenvironment of the breast...
Peritoneal washing cytologic analysis of ovarian serous tumors of low malignant potential to detect peritoneal implants and predict clinical outcomeNour Sneige
Department of Pathology, Cytopathology Section, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA
Cancer Cytopathol 120:238-44. 2012..To the best of the authors' knowledge, the ability of peritoneal washing (PW) cytology to detect the presence and type of peritoneal implants has not been adequately investigated, and its prognostic significance is unknown...
Immunohistochemical characterization of subtypes of male breast carcinomaYimin Ge
Department of Pathology, The Methodist Hospital, Weill Medical College of Cornell University, Houston, TX 77030, USA
Breast Cancer Res 11:R28. 2009....
Correlation of cytologic findings and chromosomal instability detected by fluorescence in situ hybridization in breast fine-needle aspiration specimens from women at high risk for breast cancerNour Sneige
Division of Pathology and Laboratory Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
Mod Pathol 19:622-9. 2006..Studies evaluating the association between specific patterns of chromosomal polysomy and progression to malignancy may be warranted...
Clinical, histopathologic, and biologic features of pleomorphic lobular (ductal-lobular) carcinoma in situ of the breast: a report of 24 casesNour Sneige
Division of Pathology and Laboratory Medicine, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
Mod Pathol 15:1044-50. 2002..Long-term follow-up studies are needed to further define the natural history of PL/DLCIS and its optimal management...
Low-grade (fibromatosis-like) spindle cell carcinoma of the breastN Sneige
Department of Pathology, University of Texas M D Anderson Cancer Center, Houston, Texas, USA
Am J Surg Pathol 25:1009-16. 2001..Because FLSpCCs may be underdiagnosed as benign, the use of immunohistochemical studies, especially for cytokeratins and SMA, is essential in the evaluation of any spindle cell proliferations of the breast...
Randomized trial of high-dose chemotherapy and blood cell autografts for high-risk primary breast carcinomaG N Hortobagyi
Department of Breast Medical Oncology, The University of Texas M D Anderson Cancer Center, Houston 77030, USA
J Natl Cancer Inst 92:225-33. 2000..We conducted a prospective randomized trial to compare standard-dose chemotherapy with the same therapy followed by high-dose chemotherapy. PATIENTS and..
Stability of HER2-positive status in breast carcinoma: a comparison between primary and paired metastatic tumors with regard to the possible impact of intervening trastuzumab treatmentC Xiao
Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
Ann Oncol 22:1547-53. 2011....
Molecular and biomarker analyses of salivary duct carcinomas: comparison with mammary duct carcinomaM P Hoang
Department of Pathology, The University of Texas M.D. Anderson Cancer Center, Houston, TX 77030, USA
Int J Oncol 19:865-71. 2001....
Peritoneal washing cytology in patients with BRCA1 or BRCA2 mutations undergoing risk-reducing salpingo-oophorectomies: a 10-year experience and reappraisal of its clinical utilityG Landon
Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
Gynecol Oncol 125:683-6. 2012....
Fine-needle aspiration cytology of recurrent and metastatic mixed mesodermal tumorsW A Mourad
University of Texas M D Anderson Cancer Center, Houston
Diagn Cytopathol 11:328-32. 1994..These findings confirm that the epithelial component is responsible for the malignant behaviour of MMMTs, and suggest that these lesions may need to be classified as sarcomatoid carcinomas rather than true carcinosarcomas...
Expression of growth factor and chemokine receptors: new insights in the biology of inflammatory breast cancerN Cabioglu
Department of Pathology, The University of Texas M D Anderson Cancer Center, Houston, TX 77230, USA
Ann Oncol 18:1021-9. 2007..Expression of CXCR4 and CCR7 along with the biomarkers HER2-neu and epidermal growth factor receptor (EGFR) was investigated in inflammatory breast cancer (IBC) to evaluate their prognostic implications...
Age as a predictor of outcome for women with DCIS treated with breast-conserving surgery and radiation: The University of Texas M. D. Anderson Cancer Center experienceAnuja Jhingran
Division of Radiation Oncology, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
Int J Radiat Oncol Biol Phys 54:804-9. 2002..To analyze the long-term outcome of breast conservation therapy in patients with ductal carcinoma in situ (DCIS) in a single institution and to analyze the prognostic importance, if any, of young patient age...
Cationic liposome-mediated E1A gene transfer to human breast and ovarian cancer cells and its biologic effects: a phase I clinical trialG N Hortobagyi
Department of Breast Medical Oncology, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
J Clin Oncol 19:3422-33. 2001....
Changing trends in breast fine-needle aspiration: results of the Papanicolaou Society of Cytopathology SurveyS O Tabbara
Department of Pathology, The George Washington University Medical Center, Washington, DC 20037, USA
Diagn Cytopathol 22:126-30. 2000..The issue of specimen adequacy, however, remains controversial, with some laboratories utilizing quantitative criteria, while the majority do not. Diagn. Cytopathol. 2000;22:126-130...
A single-gene biomarker identifies breast cancers associated with immature cell type and short duration of prior breastfeedingW F Symmans
Department of Pathology, University of Texas MD Anderson Cancer Center, Houston, 77030, USA
Endocr Relat Cancer 12:1059-69. 2005..036). GABApi gene expression is increased in breast cancers of immature (undifferentiated) cell type and is significantly associated with shorter lifetime history of breastfeeding and with high-grade breast cancer in Hispanic women...
Neovascularization in mucinous ductal carcinoma in situ suggests an alternative pathway for invasionS A Gadre
Department of Pathology, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
Histopathology 53:545-53. 2008..The aim was to characterize mucinous DCIS (mDCIS) of the breast and to describe, to our knowledge for the first time, neovascularization in mucin...
Fine-needle aspiration cytology of a case of oncocytic adrenocortical carcinomaS Krishnamurthy
Department of Pathology, University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
Diagn Cytopathol 22:299-303. 2000..The patient underwent left radical nephrectomy as well as a combined cardiopulmonary bypass, with atriotomy and resection of the tumor from the right atrium and inferior vena cava. Three months of postoperative follow-up were uneventful...
Paclitaxel in the multimodality treatment for inflammatory breast carcinomaM Cristofanilli
Department of Breast Medical Oncology, University of Texas, M D Anderson Cancer Center, Houston, TX 77030, USA
Cancer 92:1775-82. 2001..Reports of significant clinical activity of paclitaxel in metastatic breast carcinoma led the authors to investigate the role of this drug in the management of IBC...
Accuracy of cytologic diagnoses made from touch imprints of image-guided needle biopsy specimens of nonpalpable breast abnormalitiesN Sneige
Department of Anatomic Pathology, The University of Texas M D Anderson Cancer Center, Houston 77030, USA
Diagn Cytopathol 23:29-34. 2000..Increased experience with cytologic analysis of TIs improves the accuracy of cytologic diagnoses...
Computerized image analysis of Ki-67 in ductal breast carcinoma in situD G Menter
Departments of Clinical Cancer Prevention and Pathology, University of Texas M. D. Anderson Cancer Center, Houston, Texas, USA
Anal Quant Cytol Histol 23:218-28. 2001..As such, this method can offer (1) less intraobserver and interobserver variability, (2) a digital archival record, and (3) a baseline for digital exchange of information between studies...
Characterization of foam cells in nipple aspirate fluidS Krishnamurthy
Department of Pathology, The University of Texas, MD Anderson Cancer Center, Houston, Texas 77030, USA
Diagn Cytopathol 27:261-4; discussion 265. 2002..There was no evidence, however, of cell junctions or tonofilaments. The immunocytochemical and electron microscopic findings of our study together clearly support a macrophage derivation for foam cells in nipple aspirate fluid...
Downregulation of the cyclin-dependent kinase inhibitor p27kip1 might correlate with poor disease-free and overall survival in inflammatory breast cancerAna Maria Gonzalez-Angulo
Department of Breast Medical Oncology, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77230 1439, USA
Clin Breast Cancer 7:326-30. 2006..The objective of this study was to evaluate whether p27kip1 downregulation is a prognostic factor in patients with inflammatory breast carcinoma (IBC)...
Pharmacogenomic predictor of sensitivity to preoperative chemotherapy with paclitaxel and fluorouracil, doxorubicin, and cyclophosphamide in breast cancerKenneth R Hess
Department of Biostatistics and Applied Mathematics, The University of Texas M.D. Anderson Cancer Center, Houston, TX 77230-1439, USA
J Clin Oncol 24:4236-44. 2006..This test correctly identified all but one of the patients who achieved pCR (12 of 13 patients) and all but one of those who were predicted to have residual disease had residual cancer (27 of 28 patients)...
Sonographic and mammographic appearances of granular cell tumors of the breast with pathological correlationWei Tse Yang
Department of Diagnostic Radiology, The University of Texas M. D. Anderson Cancer Center, Houston, TX 77030, USA
J Clin Ultrasound 34:153-60. 2006..CONCLUSIONS: Breast imagers should be aware that GCT of the breast is an uncommon differential in a minority of neoplasms that can be mistaken for breast cancer...
Outcome after pathologic complete eradication of cytologically proven breast cancer axillary node metastases following primary chemotherapyBryan T Hennessy
Department of Breast Medical Oncology, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
J Clin Oncol 23:9304-11. 2005..The purpose of this study was to determine long-term outcome in patients achieving pCR of cytologically proven axillary lymph node (ALN) metastases...
Fine needle aspiration cytology of well-differentiated papillary mesothelioma: a case reportYun Gong
Department of Pathology, The University of Texas M D Anderson Cancer Center, Houston 77030, USA
Acta Cytol 49:537-42. 2005..Fine needle aspiration (FNA) of this type of tumor has rarely been reported...
Impact of concurrent proliferative high-risk lesions on the risk of ipsilateral breast carcinoma recurrence and contralateral breast carcinoma development in patients with ductal carcinoma in situ treated with breast-conserving therapyLinda J Adepoju
Department of Surgical Oncology, The University of Texas M. D. Anderson Cancer Center, Houston, Texas 77030, USA
Cancer 106:42-50. 2006..Concurrent ADH, ALH, or LCIS with DCIS is not a contraindication to BCT...
Collagenous spherulosis of breast: morphologic study of 59 cases and review of the literatureErika Resetkova
Department of Pathology, University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
Am J Surg Pathol 30:20-7. 2006..Caution is needed not to overinterpret collagenous spherulosis as atypical or ductal carcinoma in situ, especially on core needle biopsy specimens...
The feasibility of gene expression profiling generated in fine-needle aspiration specimens from patients with follicular lymphoma and diffuse large B-cell lymphomaAndre Goy
Department of Lymphoma and Myeloma, The University of Texas M D Anderson Cancer Center, Houston, Texas, USA
Cancer 108:10-20. 2006..The results support the feasibility of FNA-based transcription profiles in patients with FL or LBCL, which, in combination with morphology and immunophenotyping, can help in the subtyping of these entities...
Locoregional recurrence after doxorubicin-based chemotherapy and postmastectomy: Implications for breast cancer patients with early-stage disease and predictors for recurrence after postmastectomy radiationWendy A Woodward
Department of Radiation Oncology, The University of Texas M. D. Anderson Cancer Center, Houston 77030, USA
Int J Radiat Oncol Biol Phys 57:336-44. 2003..CONCLUSIONS: Postmastectomy radiation decreases LRR for patients with breast cancer, including those with Stage II breast cancer and one to three positive lymph nodes...
Beta4 integrin subunit gene expression correlates with tumor size and nuclear grade in early breast cancerLeslie K Diaz
Department of Pathology, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
Mod Pathol 18:1165-75. 2005....
CD44 expression is associated with increased survival in node-negative invasive breast carcinomaLeslie K Diaz
Department of Pathology, University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
Clin Cancer Res 11:3309-14. 2005..The purpose of this study was to evaluate the prognostic significance of CD44 isoforms in early-stage, lymph node-negative invasive breast carcinoma...
Metastatic hidradenocarcinoma with demonstration of Her-2/neu gene amplification by fluorescence in situ hybridization: potential treatment implicationsJason W Nash
Departments of Pathology and Dermatology, University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
J Cutan Pathol 34:49-54. 2007..In analogy to breast carcinoma, these findings suggest the applicability of trastuzumab for patients with metastatic adnexal carcinomas demonstrating Her-2/neu amplification...
Adenovirus type 5 E1A gene therapy for ovarian clear cell carcinoma: a potential treatment strategyHiroaki Itamochi
Department of Stem Cell Transplantation and Cellular Therapy, Unit 448, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
Mol Cancer Ther 6:227-35. 2007..001). E1A gene therapy, because of its ability to stabilize wild-type p53, is worth exploring as a treatment modality for women with ovarian CCC, which typically expresses wild-type p53...
Human papillomavirus genotyping for the eight oncogenic types can improve specificity of HPV testing in women with mildly abnormal Pap resultsMing Guo
Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030 4009, USA
Mod Pathol 21:1037-43. 2008....
Metastases to intramammary lymph nodes in patients with breast cancer: sonographic findingsBeth S Edeiken-Monroe
Department of Diagnostic Radiology, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
J Clin Ultrasound 36:279-85. 2008....
Clinical, histopathologic, and immunohistochemical features of microglandular adenosis and transition into in situ and invasive carcinomaIbrahim M Khalifeh
Department of Pathology, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
Am J Surg Pathol 32:544-52. 2008....
Assessment of two automated imaging systems in evaluating estrogen receptor status in breast carcinomaSumita Gokhale
Department of Pathology, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
Appl Immunohistochem Mol Morphol 15:451-5. 2007..In 4 of these, the percentage of cells staining for ER was low (0% to 20%). Overall, the 2 systems were comparable, and discrepant results were most frequently seen when analyzing tumors with low levels of ER positive cells...
Thyroid transcription factor-1 expression in endometrial and endocervical adenocarcinomasKoushan Siami
Department of Pathology, The University of Texas M D Anderson Cancer Center, Houston, TX 77030 4009, USA
Am J Surg Pathol 31:1759-63. 2007..It should also be taken into consideration in the evaluation of adenocarcinomas involving the lung in patients with a history of a gynecologic malignancy...
Triple negative breast carcinoma and the basal phenotype: from expression profiling to clinical practiceLeslie K Diaz
Piper Breast Center, Virginia Piper Cancer Institute, Abbott Northwestern Hospital, Minneapolis, MN 55407, USA
Adv Anat Pathol 14:419-30. 2007....
Evaluation of a commercialized in situ hybridization assay for detecting human papillomavirus DNA in tissue specimens from patients with cervical intraepithelial neoplasia and cervical carcinomaMing Guo
Department of Pathology, Unit 58, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX 77030 4009, USA
J Clin Microbiol 46:274-80. 2008..In addition, signal patterns, especially a mixed punctate and diffuse pattern of HPV, cannot be reliably used to predict viral integration status...
A human papillomavirus testing system in women with abnormal Pap results: a comparison study with follow-up biopsiesMing Guo
Departments of Pathology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030 4009, USA
Acta Cytol 51:749-54. 2007..To evaluate the efficacy of INFORM HPV using the SurePath collection method in women whose Pap tests indicated abnormal results...
Breast carcinoma arising in microglandular adenosis: a review of the literatureAfshin Salarieh
Division of Pathology and Laboratory Medicine, The University of Texas M D Anderson Cancer Center, Houston, USA
Arch Pathol Lab Med 131:1397-9. 2007....
Comparison of ductal lavage and random periareolar fine needle aspiration as tissue acquisition methods in early breast cancer prevention trialsBanu Arun
Breast Medical Oncology, The University of Texas, M D Anderson Cancer Center, Houston, Texas 77030, USA
Clin Cancer Res 13:4943-8. 2007..The optimum method to retrieve adequate samples and the most accepted method by study participants is not known...
Inflammatory breast cancer (IBC) and patterns of recurrence: understanding the biology of a unique diseaseMassimo Cristofanilli
Department of Breast Medical Oncology, University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
Cancer 110:1436-44. 2007..The authors compared the prognostic features of IBC and non-IBC locally advanced breast cancer (LABC) to gain insight into the biology of this disease entity...
Determination of oestrogen-receptor status and ERBB2 status of breast carcinoma: a gene-expression profiling studyYun Gong
Department of Pathology, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
Lancet Oncol 8:203-11. 2007..Our goal was to establish a new method to assign oestrogen receptor and ERBB2-receptor status to breast carcinoma based on mRNA expression measured using Affymetrix U133A gene-expression profiling...
Distribution and viral load of eight oncogenic types of human papillomavirus (HPV) and HPV 16 integration status in cervical intraepithelial neoplasia and carcinomaMing Guo
Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030 4009, USA
Mod Pathol 20:256-66. 2007..We also conclude that the HPV 16 integration status has potential to be a marker for risk assessment of CIN progression...
Reliability of chromogenic in situ hybridization for detecting HER-2 gene status in breast cancer: comparison with fluorescence in situ hybridization and assessment of interobserver reproducibilityYun Gong
Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
Mod Pathol 18:1015-21. 2005..We conclude that, in general, HER-2 status can be reliably assessed by CISH. Confirmatory FISH is recommended in cases with equivocal or borderline CISH copy numbers...
Validation of commonly used immunostains on cell-transferred cytologic specimensYun Gong
Department of Pathology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
Cancer 105:158-64. 2005..However the reliability of the staining results has not been systematically evaluated...
Total RNA yield and microarray gene expression profiles from fine-needle aspiration biopsy and core-needle biopsy samples of breast carcinomaW Fraser Symmans
Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA
Cancer 97:2960-71. 2003..This study compared gene expression profiles derived from fine-needle aspiration biopsy (FNAB) and from core needle biopsy (CBX)...
Nipple aspirate fluid cytology in breast carcinomaSavitri Krishnamurthy
Department of Pathology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
Cancer 99:97-104. 2003..Cytologic-histologic correlations of NAF were performed in only a few studies...
Histologic localization of sentinel lymph node metastases in breast cancerLeslie K Diaz
Department of Pathology, M.D. Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
Am J Surg Pathol 27:385-9. 2003..This information may be useful in determining the optimal method for evaluating axillary sentinel lymph node specimens from breast cancer patients...
Lobular carcinoma in situ diagnosed by core needle biopsy: when should it be excised?Lavinia P Middleton
Department of Pathology, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
Mod Pathol 16:120-9. 2003..Based on these findings, we recommend excisional biopsy of lobular carcinoma in situ, atypical lobular hyperplasia or lobular neoplasia only when it is associated with a synchronous mass lesion...
Mammographic-pathologic correlation of apocrine metaplasia diagnosed using vacuum-assisted stereotactic core-needle biopsy: our 4-year experienceAnne C Kushwaha
Division of Diagnostic Radiology, The University of Texas M. D. Anderson Cancer Center, 1515 Holcombe Blvd, Box 57, Houston, TX 77030, USA
AJR Am J Roentgenol 180:795-8. 2003..Because no distinguishing mammographic features are present to require follow-up by imaging, needle biopsy is required for definitive diagnosis...
Atypical ductal hyperplasia diagnosis by directional vacuum-assisted stereotactic biopsy of breast microcalcifications. Considerations for surgical excisionNour Sneige
Department of Pathology, University of Texas M.D. Anderson Cancer Center, Unit 53, 1515 Holcombe Blvd, Houston, TX 77030, USA
Am J Clin Pathol 119:248-53. 2003..When assessing microcalcifications with ADH, clinicians should consider the percentage of microcalcifications removed by DVAB and the extent of lobular involvement to better assess the need for excision...
Phase II study of weekly docetaxel and trastuzumab for patients with HER-2-overexpressing metastatic breast cancerFrancisco J Esteva
Department of Breast Medical Oncology, The University of Texas M D Anderson Cancer Center, Houston, TX, USA
J Clin Oncol 20:1800-8. 2002..To evaluate the safety and efficacy of weekly docetaxel plus trastuzumab in women with HER-2-overexpressing metastatic breast cancer. Efficacy was correlated with serum HER-2 extracellular domain (ECD) levels...
Phase II clinical trial of N-(4-Hydroxyphenyl)retinamide and tamoxifen administration before definitive surgery for breast neoplasiaS Eva Singletary
Department of Surgical Oncology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
Clin Cancer Res 8:2835-42. 2002..Surrogate end point biomarkers (SEBs) that can be measured in ductal carcinoma in situ or early-stage invasive cancer are needed to improve the efficiency and reduce the cost of chemoprevention trials...
Role of ultrasound-guided fine-needle aspiration of indeterminate and suspicious axillary lymph nodes in the initial staging of breast carcinomaSavitri Krishnamurthy
Department of Pathology, M D Anderson Cancer Center, Houston, Texas 77030, USA
Cancer 95:982-8. 2002..This study was undertaken to determine the diagnostic accuracy of US-guided FNA of indeterminate/suspicious/metastatic-appearing axillary lymph nodes during the initial staging of breast carcinoma...
Intraoperative touch imprint of sentinel lymph nodes in breast carcinoma patientsAndrea Lee
Department of Pathology, University of Texas M.D. Anderson Cancer Center, Houston, Texas 77030, USA
Cancer 96:225-31. 2002..The difficulty of identifying micrometastases appeared to be the major source of false negative events, a problem that is not unique to TI cytology...
Pathologic tumor size and lymph node status predict for different rates of locoregional recurrence after mastectomy for breast cancer patients treated with neoadjuvant versus adjuvant chemotherapyThomas A Buchholz
Department of Radiation Oncology, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
Int J Radiat Oncol Biol Phys 53:880-8. 2002..To compare the pathologic factors associated with postmastectomy locoregional recurrence (LRR) in breast cancer patients not receiving radiation who were treated with neoadjuvant chemotherapy (NEO) vs. adjuvant chemotherapy (ADJ)...
Her-2/neu gene amplification in ductal carcinoma in situ of the breastAshraful Hoque
Departments of Clinical Cancer Prevention, The University of Texas M. D. Anderson Cancer Center, Houston, Texas 77030, USA
Cancer Epidemiol Biomarkers Prev 11:587-90. 2002..g., p21 and Rb) as markers of the risk of DCIS patients for invasive breast cancer and as molecular targets of chemoprevention in breast intraepithelial neoplasia...
Interventional breast sonographyBruno D Fornage
Department of Diagnostic Radiology, The University of Texas M D Anderson Cancer Center, Box 57, 1515 Holcombe Boulevard, Houston, TX 77030, USA
Eur J Radiol 42:17-31. 2002..However, on occasion, clusters of microcalcifications without a mass can be visualized on sonograms with sufficient clarity to undertake a US-guided core biopsy if stereotactically guided biopsy cannot be performed for technical reasons...
Gene expression profiles obtained from fine-needle aspirations of breast cancer reliably identify routine prognostic markers and reveal large-scale molecular differences between estrogen-negative and estrogen-positive tumorsLajos Pusztai
Departments of Breast Medical Oncology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030 009, USA
Clin Cancer Res 9:2406-15. 2003..33)P]dCTP-labeled cDNA probes were generated and hybridized to cDNA membrane microarrays that contained 30,000 human sequence clones, including 10,890 expressed sequence tags...
Detection of numerical aberrations of chromosomes 7 and 9 in cytologic specimens of pleural malignant mesotheliomaHyung Ju C Shin
Department of Pathology, The University of Texas M D Anderson Cancer Center, Houston, Texas, USA
Cancer 99:233-9. 2003..The authors attempted to determine whether the detection of numerical chromosomal aberrations in the effusion fluid specimens could be a useful diagnostic adjunct in morphologically inconclusive cases for MM...
Accuracy of core needle biopsy diagnosis in assessing papillary breast lesions: histologic predictors of malignancyDoina Ivan
Department of Pathology, The University of Texas-Houston, Houston, TX, USA
Mod Pathol 17:165-71. 2004..0001) than is the presence of mitoses (P<0.053). A diagnosis of carcinoma or atypical papilloma by CNB should warrant an EB, whereas benign papillomas may be followed if imaging findings are concordant...
Comparison of HER-2 status determined by fluorescence in situ hybridization in primary and metastatic breast carcinomaYun Gong
Department of Pathology, The University of Texas M. D. Anderson Cancer Center, Houston, Texas 77030, USA
Cancer 103:1763-9. 2005..Therefore, HER-2 amplification can be evaluated reliably in material from either primary or metastatic tumors in most patients. Further study with larger series is warranted to elucidate the significance of discordant results...
Pathologic quiz case: a large, ill-defined cystic breast mass. Invasive cystic hypersecretory duct carcinomaErika Resetkova
Department of Pathology, The University of Texas M. D. Anderson Cancer Center, Houston 77030, USA
Arch Pathol Lab Med 129:e79-80. 2005
Invasive lobular carcinoma classic type: response to primary chemotherapy and survival outcomesMassimo Cristofanilli
Department of Breast Medical Oncology, Unit 424, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX 77030 4009, USA
J Clin Oncol 23:41-8. 2005..To investigate the impact of histologic type invasive lobular carcinoma (ILC) versus invasive ductal carcinoma (IDC) on response to primary chemotherapy (PC) and long-term outcome...
Estrogen receptor analysis for breast cancer: current issues and keys to increasing testing accuracyLeslie K Diaz
Department of Pathology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA
Adv Anat Pathol 12:10-9. 2005..We additionally highlight recent biologic, molecular, and gene expression profiling data related to ER in breast cancer...
Fine-needle aspiration cytology of a liver metastasis of follicular dendritic cell sarcomaRulong Ren
Department of Pathology, Ball Memorial Hospital, Muncie, Indiana, USA
Diagn Cytopathol 32:38-43. 2005..We review the literature on this entity with emphasis on FNA cytomorphology, differential diagnosis, and immunohistochemical findings...
p53 expression as a prognostic marker in inflammatory breast cancerAna M Gonzalez-Angulo
Department of Breast Medical Oncology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
Clin Cancer Res 10:6215-21. 2004..We retrospectively analyze the expression of p53 as a prognostic marker to predict pathological complete response and survival in patients with IBC...
Feasibility and utility of using chromosomal aneusomy to further define the cytologic categories in nipple aspirate fluid specimens: a preliminary studySavitri Krishnamurthy
Department of Cytopathology, Unit 53, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
Cancer 102:322-7. 2004....
Prognostic value of P53, MDM-2, and MUC-1 for patients with inflammatory breast carcinomaErika Resetkova
Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston 77030, USA
Cancer 101:913-7. 2004..CONCLUSIONS: Expression of P53 and MUC-1 may be predictive of treatment efficacy and outcome for patients with IBC. Furthermore, these two markers may represent novel therapeutic targets in such patients...
Expression of BAG-1 and BcL-2 proteins before and after neoadjuvant chemotherapy of locally advanced breast cancerLajos Pusztai
Department of Breast Medical Oncology, University of Texas M D Anderson Cancer Center, Box 424, 1515 Holcombe Blvd, Houston, TX 77030 4009, USA
Cancer Invest 22:248-56. 2004..However, it does not appear to determine response to doxorubicin-based chemotherapy. In contrast, lack of Bcl-2 expression was associated with a higher probability of complete pathological response to doxorubicin-based chemotherapy...
Interobserver agreement of a probabilistic approach to reporting breast fine-needle aspirations on ThinPrepBradley Gornstein
Department of Pathology, Beth Israel Deaconess Medical Center, Boston, Massachusetts 02215, USA
Diagn Cytopathol 30:389-95. 2004..The specific level of experience interpreting breast FNA or using ThinPrep among experienced pathologists did not seem to influence their accuracy in reporting the cases in our study...
The use of TMA for interlaboratory validation of FISH testing for detection of HER2 gene amplification in breast cancerLeslie K Diaz
Department of Pathology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611, USA
J Histochem Cytochem 52:501-7. 2004..Good concordance was observed between HER2 IHC and in situ hybridization testing. TMA is a robust and effective method for the technical validation of HER2 FISH testing and should be considered for use by quality assessment programs...
Utility of cytologic specimens in the evaluation of prognostic and predictive factors of breast cancer: current issues and future directionsNour Sneige
Department of Pathology, University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
Diagn Cytopathol 30:158-65. 2004..Such investigational studies are under way and offer great potential for revolutionizing the prediction of patient outcomes and disease response to therapy, as well as assessment of risk of developing breast cancer...
Optimal fixation conditions for immunocytochemical analysis of estrogen receptor in cytologic specimens of breast carcinomaYun Gong
Department of Pathology, The University of Texas M. D. Anderson Cancer Center, Houston, Texas 77030, USA
Cancer 102:34-40. 2004..Air-drying, destaining Pap smear, and fixation in formalin or Carnoy's-Pap without antigen retrieval are not recommended...
Immunocytochemical evaluation of estrogen receptor on archival Papanicolaou-stained fine-needle aspirate smearsSavitri Krishnamurthy
Department of Pathology, MD Anderson Cancer Center, The University of Texas, Houston, Texas 77030, USA
Diagn Cytopathol 29:309-14. 2003..Because significant differences in ER-IC staining can occur with any of the immunocytochemical methods, a negative result is less reliable as an indicator of true ER status than a positive result...
Molecular and biologic markers of premalignant lesions of human breastSavitri Krishnamurthy
Department of Pathology, The University of Texas, M.D. Anderson Cancer Center, Houston, USA
Adv Anat Pathol 9:185-97. 2002....
