Agata Smogorzewska

Summary

Affiliation: The Rockefeller University
Country: USA

Publications

  1. ncbi A genetic screen identifies FAN1, a Fanconi anemia-associated nuclease necessary for DNA interstrand crosslink repair
    Agata Smogorzewska
    Howard Hughes Medical Institute, Department of Genetics, Harvard Medical School, and Brigham and Women s Hospital, Boston, MA 02115, USA
    Mol Cell 39:36-47. 2010
  2. ncbi ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage
    Shuhei Matsuoka
    Department of Genetics and Center for Genetics and Genomics, Brigham and Women s Hospital, Howard Hughes Medical Institute, Harvard Medical School, Boston, MA 02115, USA
    Science 316:1160-6. 2007
  3. ncbi Mammalian BTBD12/SLX4 assembles a Holliday junction resolvase and is required for DNA repair
    Jennifer M Svendsen
    Department of Pathology, Harvard Medical School, Boston, MA 02115, USA
    Cell 138:63-77. 2009
  4. ncbi Abraxas and RAP80 form a BRCA1 protein complex required for the DNA damage response
    Bin Wang
    Department of Genetics, Center for Genetics and Genomics, Brigham and Women s Hospital, Howard Hughes Medical Institute, Harvard Medical School, Boston, MA 02115, USA
    Science 316:1194-8. 2007
  5. ncbi A genome-wide homologous recombination screen identifies the RNA-binding protein RBMX as a component of the DNA-damage response
    Britt Adamson
    Howard Hughes Medical Institute, Department of Genetics, Harvard Medical School, Division of Genetics, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    Nat Cell Biol 14:318-28. 2012
  6. ncbi Cancer proliferation gene discovery through functional genomics
    Michael R Schlabach
    Howard Hughes Medical Institute and Department of Genetics, Center for Genetics and Genomics, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Science 319:620-4. 2008
  7. ncbi The Fanconi anemia pathway promotes replication-dependent DNA interstrand cross-link repair
    Puck Knipscheer
    Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115, USA
    Science 326:1698-701. 2009
  8. ncbi Polybromo-associated BRG1-associated factor components BRD7 and BAF180 are critical regulators of p53 required for induction of replicative senescence
    Anna E Burrows
    The Howard Hughes Medical Institute and Department of Genetics, Harvard Medical School, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 107:14280-5. 2010
  9. ncbi Identification of the FANCI protein, a monoubiquitinated FANCD2 paralog required for DNA repair
    Agata Smogorzewska
    Department of Genetics, Howard Hughes Medical Institute, Center for Genetics and Genomics, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Cell 129:289-301. 2007

Collaborators

Detail Information

Publications9

  1. ncbi A genetic screen identifies FAN1, a Fanconi anemia-associated nuclease necessary for DNA interstrand crosslink repair
    Agata Smogorzewska
    Howard Hughes Medical Institute, Department of Genetics, Harvard Medical School, and Brigham and Women s Hospital, Boston, MA 02115, USA
    Mol Cell 39:36-47. 2010
    ..We propose that FAN1 is a repair nuclease that is recruited to sites of crosslink damage in part through binding the ubiquitinated ID complex through its UBZ domain...
  2. ncbi ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage
    Shuhei Matsuoka
    Department of Genetics and Center for Genetics and Genomics, Brigham and Women s Hospital, Howard Hughes Medical Institute, Harvard Medical School, Boston, MA 02115, USA
    Science 316:1160-6. 2007
    ..This database paints a much broader landscape for the DDR than was previously appreciated and opens new avenues of investigation into the responses to DNA damage in mammals...
  3. ncbi Mammalian BTBD12/SLX4 assembles a Holliday junction resolvase and is required for DNA repair
    Jennifer M Svendsen
    Department of Pathology, Harvard Medical School, Boston, MA 02115, USA
    Cell 138:63-77. 2009
    ..Thus, SLX4 assembles a modular toolkit for repair of specific types of DNA lesions and is critical for cellular responses to replication fork failure...
  4. ncbi Abraxas and RAP80 form a BRCA1 protein complex required for the DNA damage response
    Bin Wang
    Department of Genetics, Center for Genetics and Genomics, Brigham and Women s Hospital, Howard Hughes Medical Institute, Harvard Medical School, Boston, MA 02115, USA
    Science 316:1194-8. 2007
    ..The RAP80-Abraxas complex may help recruit BRCA1 to DNA damage sites in part through recognition of ubiquitinated proteins...
  5. ncbi A genome-wide homologous recombination screen identifies the RNA-binding protein RBMX as a component of the DNA-damage response
    Britt Adamson
    Howard Hughes Medical Institute, Department of Genetics, Harvard Medical School, Division of Genetics, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    Nat Cell Biol 14:318-28. 2012
    ..Our screen also revealed that off-target depletion of RAD51 is a common source of RNAi false positives, raising a cautionary note for siRNA screens and RNAi-based studies of HR...
  6. ncbi Cancer proliferation gene discovery through functional genomics
    Michael R Schlabach
    Howard Hughes Medical Institute and Department of Genetics, Center for Genetics and Genomics, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Science 319:620-4. 2008
    ..Such efforts are complementary to the Cancer Genome Atlas and provide an alternative functional view of cancer cells...
  7. ncbi The Fanconi anemia pathway promotes replication-dependent DNA interstrand cross-link repair
    Puck Knipscheer
    Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115, USA
    Science 326:1698-701. 2009
    ..Reversal of these defects requires ubiquitylated FANCI-FANCD2. Our results show that multiple steps of the essential S-phase ICL repair mechanism fail when the Fanconi anemia pathway is compromised...
  8. ncbi Polybromo-associated BRG1-associated factor components BRD7 and BAF180 are critical regulators of p53 required for induction of replicative senescence
    Anna E Burrows
    The Howard Hughes Medical Institute and Department of Genetics, Harvard Medical School, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 107:14280-5. 2010
    ..BRD7 is a deletion target in human cancer, suggesting that loss of BRD7 may provide an additional mechanism to antagonize p53 function in cancer cells...
  9. ncbi Identification of the FANCI protein, a monoubiquitinated FANCD2 paralog required for DNA repair
    Agata Smogorzewska
    Department of Genetics, Howard Hughes Medical Institute, Center for Genetics and Genomics, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Cell 129:289-301. 2007
    ..Mutation in FANCI is responsible for loss of a functional FA pathway in a patient with Fanconi anemia complementation group I...