Agata Smogorzewska

Summary

Affiliation: The Rockefeller University
Country: USA

Publications

  1. pmc Mutations of the SLX4 gene in Fanconi anemia
    Yonghwan Kim
    Laboratory of Genome Maintenance, The Rockefeller University, New York, New York, USA
    Nat Genet 43:142-6. 2011
  2. pmc A genetic screen identifies FAN1, a Fanconi anemia-associated nuclease necessary for DNA interstrand crosslink repair
    Agata Smogorzewska
    Howard Hughes Medical Institute, Department of Genetics, Harvard Medical School, and Brigham and Women s Hospital, Boston, MA 02115, USA
    Mol Cell 39:36-47. 2010
  3. pmc Regulation of multiple DNA repair pathways by the Fanconi anemia protein SLX4
    Yonghwan Kim
    Laboratory of Genome Maintenance, Rockefeller University, New York, NY 10065 6399, USA
    Blood 121:54-63. 2013
  4. ncbi request reprint ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage
    Shuhei Matsuoka
    Department of Genetics and Center for Genetics and Genomics, Brigham and Women s Hospital, Howard Hughes Medical Institute, Harvard Medical School, Boston, MA 02115, USA
    Science 316:1160-6. 2007
  5. pmc Mammalian BTBD12/SLX4 assembles a Holliday junction resolvase and is required for DNA repair
    Jennifer M Svendsen
    Department of Pathology, Harvard Medical School, Boston, MA 02115, USA
    Cell 138:63-77. 2009
  6. pmc Abraxas and RAP80 form a BRCA1 protein complex required for the DNA damage response
    Bin Wang
    Department of Genetics, Center for Genetics and Genomics, Brigham and Women s Hospital, Howard Hughes Medical Institute, Harvard Medical School, Boston, MA 02115, USA
    Science 316:1194-8. 2007
  7. pmc Structure of the FANCI-FANCD2 complex: insights into the Fanconi anemia DNA repair pathway
    Woo Joo
    Structural Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
    Science 333:312-6. 2011
  8. pmc A genome-wide homologous recombination screen identifies the RNA-binding protein RBMX as a component of the DNA-damage response
    Britt Adamson
    Howard Hughes Medical Institute, Department of Genetics, Harvard Medical School, Division of Genetics, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    Nat Cell Biol 14:318-28. 2012
  9. pmc The Fanconi anemia pathway promotes replication-dependent DNA interstrand cross-link repair
    Puck Knipscheer
    Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115, USA
    Science 326:1698-701. 2009
  10. ncbi request reprint Homologous recombination generates T-loop-sized deletions at human telomeres
    Richard C Wang
    Laboratory for Cell Biology and Genetics, The Rockefeller University, 1230 York Avenue, New York, NY 10021, USA
    Cell 119:355-68. 2004

Collaborators

Detail Information

Publications18

  1. pmc Mutations of the SLX4 gene in Fanconi anemia
    Yonghwan Kim
    Laboratory of Genome Maintenance, The Rockefeller University, New York, New York, USA
    Nat Genet 43:142-6. 2011
    ....
  2. pmc A genetic screen identifies FAN1, a Fanconi anemia-associated nuclease necessary for DNA interstrand crosslink repair
    Agata Smogorzewska
    Howard Hughes Medical Institute, Department of Genetics, Harvard Medical School, and Brigham and Women s Hospital, Boston, MA 02115, USA
    Mol Cell 39:36-47. 2010
    ..We propose that FAN1 is a repair nuclease that is recruited to sites of crosslink damage in part through binding the ubiquitinated ID complex through its UBZ domain...
  3. pmc Regulation of multiple DNA repair pathways by the Fanconi anemia protein SLX4
    Yonghwan Kim
    Laboratory of Genome Maintenance, Rockefeller University, New York, NY 10065 6399, USA
    Blood 121:54-63. 2013
    ..These results demonstrate that SLX4 modulates multiple DNA repair pathways by regulating appropriate nucleases...
  4. ncbi request reprint ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage
    Shuhei Matsuoka
    Department of Genetics and Center for Genetics and Genomics, Brigham and Women s Hospital, Howard Hughes Medical Institute, Harvard Medical School, Boston, MA 02115, USA
    Science 316:1160-6. 2007
    ..This database paints a much broader landscape for the DDR than was previously appreciated and opens new avenues of investigation into the responses to DNA damage in mammals...
  5. pmc Mammalian BTBD12/SLX4 assembles a Holliday junction resolvase and is required for DNA repair
    Jennifer M Svendsen
    Department of Pathology, Harvard Medical School, Boston, MA 02115, USA
    Cell 138:63-77. 2009
    ..Thus, SLX4 assembles a modular toolkit for repair of specific types of DNA lesions and is critical for cellular responses to replication fork failure...
  6. pmc Abraxas and RAP80 form a BRCA1 protein complex required for the DNA damage response
    Bin Wang
    Department of Genetics, Center for Genetics and Genomics, Brigham and Women s Hospital, Howard Hughes Medical Institute, Harvard Medical School, Boston, MA 02115, USA
    Science 316:1194-8. 2007
    ..The RAP80-Abraxas complex may help recruit BRCA1 to DNA damage sites in part through recognition of ubiquitinated proteins...
  7. pmc Structure of the FANCI-FANCD2 complex: insights into the Fanconi anemia DNA repair pathway
    Woo Joo
    Structural Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
    Science 333:312-6. 2011
    ....
  8. pmc A genome-wide homologous recombination screen identifies the RNA-binding protein RBMX as a component of the DNA-damage response
    Britt Adamson
    Howard Hughes Medical Institute, Department of Genetics, Harvard Medical School, Division of Genetics, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    Nat Cell Biol 14:318-28. 2012
    ..Our screen also revealed that off-target depletion of RAD51 is a common source of RNAi false positives, raising a cautionary note for siRNA screens and RNAi-based studies of HR...
  9. pmc The Fanconi anemia pathway promotes replication-dependent DNA interstrand cross-link repair
    Puck Knipscheer
    Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115, USA
    Science 326:1698-701. 2009
    ..Reversal of these defects requires ubiquitylated FANCI-FANCD2. Our results show that multiple steps of the essential S-phase ICL repair mechanism fail when the Fanconi anemia pathway is compromised...
  10. ncbi request reprint Homologous recombination generates T-loop-sized deletions at human telomeres
    Richard C Wang
    Laboratory for Cell Biology and Genetics, The Rockefeller University, 1230 York Avenue, New York, NY 10021, USA
    Cell 119:355-68. 2004
    ..These findings show that t-loop deletion by HR influences the integrity and dynamics of mammalian telomeres...
  11. pmc Cancer proliferation gene discovery through functional genomics
    Michael R Schlabach
    Howard Hughes Medical Institute and Department of Genetics, Center for Genetics and Genomics, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Science 319:620-4. 2008
    ..Such efforts are complementary to the Cancer Genome Atlas and provide an alternative functional view of cancer cells...
  12. ncbi request reprint Regulation of telomerase by telomeric proteins
    Agata Smogorzewska
    The Rockefeller University, New York, New York 10021, USA
    Annu Rev Biochem 73:177-208. 2004
    ..Here we discuss the details of telomerase and its regulation by the telomere...
  13. pmc Polybromo-associated BRG1-associated factor components BRD7 and BAF180 are critical regulators of p53 required for induction of replicative senescence
    Anna E Burrows
    The Howard Hughes Medical Institute and Department of Genetics, Harvard Medical School, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 107:14280-5. 2010
    ..BRD7 is a deletion target in human cancer, suggesting that loss of BRD7 may provide an additional mechanism to antagonize p53 function in cancer cells...
  14. pmc Human GEN1 and the SLX4-associated nucleases MUS81 and SLX1 are essential for the resolution of replication-induced Holliday junctions
    Elizabeth Garner
    Laboratory of Genome Maintenance, The Rockefeller University, New York, NY 10065, USA
    Cell Rep 5:207-15. 2013
    ..In vivo HJ resolution depends on both SLX4-associated MUS81-EME1 and SLX1, suggesting that they are acting in concert in the context of SLX4. ..
  15. pmc Ubiquitylation and the Fanconi anemia pathway
    Elizabeth Garner
    Laboratory of Genome Maintenance, The Rockefeller University, New York, NY 10065, USA
    FEBS Lett 585:2853-60. 2011
    ..Importantly, ubiquitylation provides the foundations for cross-talk between repair pathways, which in concert with the FA pathway, resolve interstrand crosslink damage and maintain genomic stability...
  16. pmc Identification of the FANCI protein, a monoubiquitinated FANCD2 paralog required for DNA repair
    Agata Smogorzewska
    Department of Genetics, Howard Hughes Medical Institute, Center for Genetics and Genomics, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Cell 129:289-301. 2007
    ..Mutation in FANCI is responsible for loss of a functional FA pathway in a patient with Fanconi anemia complementation group I...
  17. pmc Fanconi anaemia and the repair of Watson and Crick DNA crosslinks
    Molly C Kottemann
    Laboratory of Genome Maintenance, The Rockefeller University, New York 10065, USA
    Nature 493:356-63. 2013
    ..Recent advances have identified endogenous aldehydes as possible culprits of DNA damage that may induce the phenotypes seen in patients with Fanconi anaemia...
  18. ncbi request reprint DNA damage foci at dysfunctional telomeres
    Hiroyuki Takai
    Laboratory for Cell Biology and Genetics, The Rockefeller University, New York, NY 10021, USA
    Curr Biol 13:1549-56. 2003
    ..Furthermore, induction of TIFs through TRF2 inhibition provides an opportunity to study the DNA damage response within the context of well-defined, physically marked lesions...