Jeffrey W Smith

Summary

Affiliation: The Burnham Institute
Country: USA

Publications

  1. ncbi request reprint Selection and structure of ion-selective ligands for platelet integrin alpha IIb(beta) 3
    Jeffrey W Smith
    Program on Cell Adhesion, Cancer Research Center, The Burnham Institute, La Jolla, California 92037, USA
    J Biol Chem 277:10298-305. 2002
  2. ncbi request reprint Cilengitide Merck
    Jeffrey W Smith
    Burnham Institute, 10901 N Torrey Pines Road, La Jolla, CA 92037 1005, USA
    Curr Opin Investig Drugs 4:741-5. 2003
  3. pmc Fabrication of PLGA nanoparticles with a fluidic nanoprecipitation system
    Hui Xie
    Sanford Burnham Medical Research Institute, 10901 North Torrey Pines Road, La Jolla, CA 92037 USA
    J Nanobiotechnology 8:18. 2010
  4. pmc The two-component NS2B-NS3 proteinase represses DNA unwinding activity of the West Nile virus NS3 helicase
    Andrei V Chernov
    Burnham Institute for Medical Research, La Jolla, California 92037, USA
    J Biol Chem 283:17270-8. 2008
  5. pmc Switching the substrate specificity of the two-component NS2B-NS3 flavivirus proteinase by structure-based mutagenesis
    Sergey A Shiryaev
    The Burnham Institute, 10901 North Torrey Pines Road, La Jolla, CA, USA
    J Virol 81:4501-9. 2007
  6. doi request reprint Structure-based mutagenesis identifies important novel determinants of the NS2B cofactor of the West Nile virus two-component NS2B-NS3 proteinase
    Ilian Radichev
    Inflammatory and Infectious Disease Center, Burnham Institute for Medical Research, La Jolla, CA 92037, USA
    J Gen Virol 89:636-41. 2008
  7. ncbi request reprint Proteolysis of the membrane type-1 matrix metalloproteinase prodomain: implications for a two-step proteolytic processing and activation
    Vladislav S Golubkov
    Burnham Institute for Medical Research, La Jolla, California 92037, USA
    J Biol Chem 282:36283-91. 2007
  8. pmc Glutamine-fueled mitochondrial metabolism is decoupled from glycolysis in melanoma
    Fabian V Filipp
    Cancer Research Center, Sanford Burnham Medical Research Institute, La Jolla, CA, USA
    Pigment Cell Melanoma Res 25:732-9. 2012
  9. pmc Cleavage preference distinguishes the two-component NS2B-NS3 serine proteinases of Dengue and West Nile viruses
    Sergey A Shiryaev
    Burnham Institute for Medical Research, La Jolla, CA 92037, USA
    Biochem J 401:743-52. 2007
  10. pmc Substrate cleavage analysis of furin and related proprotein convertases. A comparative study
    Albert G Remacle
    Burnham Institute for Medical Research, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA
    J Biol Chem 283:20897-906. 2008

Research Grants

Collaborators

Detail Information

Publications53

  1. ncbi request reprint Selection and structure of ion-selective ligands for platelet integrin alpha IIb(beta) 3
    Jeffrey W Smith
    Program on Cell Adhesion, Cancer Research Center, The Burnham Institute, La Jolla, California 92037, USA
    J Biol Chem 277:10298-305. 2002
    ..All peptides formed turns, with the RGD motif at the apex. The Mg(2+)-selected peptides contained a unique basic patch that protrudes from the base of the turn...
  2. ncbi request reprint Cilengitide Merck
    Jeffrey W Smith
    Burnham Institute, 10901 N Torrey Pines Road, La Jolla, CA 92037 1005, USA
    Curr Opin Investig Drugs 4:741-5. 2003
    ..These were ongoing in February 2002, by which time, a phase I trial and a phase I/II trial in glioblastoma were underway...
  3. pmc Fabrication of PLGA nanoparticles with a fluidic nanoprecipitation system
    Hui Xie
    Sanford Burnham Medical Research Institute, 10901 North Torrey Pines Road, La Jolla, CA 92037 USA
    J Nanobiotechnology 8:18. 2010
    ..We developed a novel Fluidic NanoPrecipitation System (FNPS) to fabricate highly uniform PLGA particles. Several parameters can be fine-tuned to generate particles of various sizes...
  4. pmc The two-component NS2B-NS3 proteinase represses DNA unwinding activity of the West Nile virus NS3 helicase
    Andrei V Chernov
    Burnham Institute for Medical Research, La Jolla, California 92037, USA
    J Biol Chem 283:17270-8. 2008
    ....
  5. pmc Switching the substrate specificity of the two-component NS2B-NS3 flavivirus proteinase by structure-based mutagenesis
    Sergey A Shiryaev
    The Burnham Institute, 10901 North Torrey Pines Road, La Jolla, CA, USA
    J Virol 81:4501-9. 2007
    ....
  6. doi request reprint Structure-based mutagenesis identifies important novel determinants of the NS2B cofactor of the West Nile virus two-component NS2B-NS3 proteinase
    Ilian Radichev
    Inflammatory and Infectious Disease Center, Burnham Institute for Medical Research, La Jolla, CA 92037, USA
    J Gen Virol 89:636-41. 2008
    ..Because of the significant level of homology in flaviviral NS2B-NS3pro, our results will be useful for the development of specific allosteric inhibitors designed to interfere with the productive interactions of NS2B with NS3pro...
  7. ncbi request reprint Proteolysis of the membrane type-1 matrix metalloproteinase prodomain: implications for a two-step proteolytic processing and activation
    Vladislav S Golubkov
    Burnham Institute for Medical Research, La Jolla, California 92037, USA
    J Biol Chem 282:36283-91. 2007
    ..These findings shed more light on the functional role of the inhibitory prodomain and on the proteolytic control of MT1-MMP activation, a crucial process that may be differentially regulated in normal and cancer cells...
  8. pmc Glutamine-fueled mitochondrial metabolism is decoupled from glycolysis in melanoma
    Fabian V Filipp
    Cancer Research Center, Sanford Burnham Medical Research Institute, La Jolla, CA, USA
    Pigment Cell Melanoma Res 25:732-9. 2012
    ..Biosynthetic networks linked with non-essential amino acids alanine, serine, arginine, and proline are also significantly impacted by the use of glutamine as an alternate carbon source...
  9. pmc Cleavage preference distinguishes the two-component NS2B-NS3 serine proteinases of Dengue and West Nile viruses
    Sergey A Shiryaev
    Burnham Institute for Medical Research, La Jolla, CA 92037, USA
    Biochem J 401:743-52. 2007
    ..We believe that our data represent a valuable biochemical resource and a solid foundation to support the design of selective substrates and synthetic inhibitors of flaviviral proteinases...
  10. pmc Substrate cleavage analysis of furin and related proprotein convertases. A comparative study
    Albert G Remacle
    Burnham Institute for Medical Research, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA
    J Biol Chem 283:20897-906. 2008
    ..Our results also suggest that pathogens, including anthrax PA83 and the avian influenza A H5N1 (bird flu) hemagglutinin precursor, evolved to be as sensitive to PC proteolysis as the most sensitive normal human proteins...
  11. pmc Expression and purification of a two-component flaviviral proteinase resistant to autocleavage at the NS2B-NS3 junction region
    Sergey A Shiryaev
    Inflammatory and Infectious Disease Center, Burnham Institute for Medical Research, La Jolla, CA 92037, USA
    Protein Expr Purif 52:334-9. 2007
    ..This construct exhibits high stability and functional activity and is thus well suited for the follow-up purification and structural and drug design studies...
  12. pmc Unusual binding of ursodeoxycholic acid to ileal bile acid binding protein: role in activation of FXRα
    Changming Fang
    Cancer Research Center, Sanford Burnham Medical Research Institute, La Jolla, CA 92037, USA
    J Lipid Res 53:664-73. 2012
    ..Furthermore, IBABP is necessary for the full activation of farnesoid X receptor α (FXRα) by bile acids, including UDCA. These observations suggest that IBABP may have a role in mediating some of the intestinal effects of UDCA...
  13. pmc Genome-wide changes accompanying knockdown of fatty acid synthase in breast cancer
    Lynn M Knowles
    Cancer Research Center, Burnham Institute for Medical Research, La Jolla, CA 92037, USA
    BMC Genomics 8:168. 2007
    ..Inhibition of tumor FAS causes both cell cycle arrest and apoptosis, indicating FAS is a promising target for cancer treatment...
  14. pmc Synthesis of novel beta-lactone inhibitors of fatty acid synthase
    Robyn D Richardson
    NCI Cancer Center, The Burnham Institute for Medical Research, 10901 North Torrey Pines Road, La Jolla, California 92037, USA
    J Med Chem 51:5285-96. 2008
    ..These findings support the idea that an orlistat congener can be optimized for use in a preclinical drug design and for clinical drug development...
  15. pmc Inhibition of fatty-acid synthase induces caspase-8-mediated tumor cell apoptosis by up-regulating DDIT4
    Lynn M Knowles
    Cancer Research Center, Burham Institute for Medical Research, La Jolla, California 92037, USA
    J Biol Chem 283:31378-84. 2008
    ..These findings indicate that suppression of palmitate synthesis is not sufficient for eliciting tumor cell death and suggest that the unique effect of inhibition of FAS results from negative regulation of the mTOR pathway via DDIT4...
  16. pmc Competitive interactions of collagen and a jararhagin-derived disintegrin peptide with the integrin alpha2-I domain
    Lester J Lambert
    Burnham Institute for Medical Research, La Jolla, California 92037, USA
    J Biol Chem 283:16665-72. 2008
    ....
  17. ncbi request reprint Targeting host cell furin proprotein convertases as a therapeutic strategy against bacterial toxins and viral pathogens
    Sergey A Shiryaev
    Burnham Institute for Medical Research, La Jolla, California 92037, USA
    J Biol Chem 282:20847-53. 2007
    ..Our results confirm that inhibiting furin-like PCs protects the host from the distinct furin-dependent infections and lay a foundation for novel, host cell-focused therapies against acute diseases...
  18. pmc Mitochondrial p32 protein is a critical regulator of tumor metabolism via maintenance of oxidative phosphorylation
    Valentina Fogal
    Cancer Research Center, Burnham Institute for Medical Research, 10901 N Torrey Pines Rd, La Jolla, California 92037, USA
    Mol Cell Biol 30:1303-18. 2010
    ....
  19. pmc Reverse TCA cycle flux through isocitrate dehydrogenases 1 and 2 is required for lipogenesis in hypoxic melanoma cells
    Fabian V Filipp
    Sanford Burnham Medical Research Institute, Cancer Research Center, La Jolla, CA, USA
    Pigment Cell Melanoma Res 25:375-83. 2012
    ..This reductive carboxylation is catalyzed by two isocitrate dehydrogenases, IDH1 and IDH2. Their combined action is necessary and sufficient to effect the reverse TCA flux and maintain cellular viability...
  20. pmc Cleavage targets and the D-arginine-based inhibitors of the West Nile virus NS3 processing proteinase
    Sergey A Shiryaev
    The Burnham Institute, La Jolla, CA 92037, USA
    Biochem J 393:503-11. 2006
    ..Overall, our findings represent a foundation for in-depth mechanistic and structural studies as well as for the design of novel and efficient inhibitors of WNV NS3...
  21. pmc Crystal and solution structures of a prokaryotic M16B peptidase: an open and shut case
    Alexander E Aleshin
    Burnham Institute for Medical Research, La Jolla, CA 92037, USA
    Structure 17:1465-75. 2009
    ..Moreover, clam-shell closure is required for proteolytic activity. We predict that other prokaryotic M16B family members will form dimeric peptidasomes, and propose a model for the evolution of the M16 family...
  22. pmc Inflammatory proprotein convertase-matrix metalloproteinase proteolytic pathway in antigen-presenting cells as a step to autoimmune multiple sclerosis
    Sergey A Shiryaev
    Burnham Institute for Medical Research, La Jolla, California 92037, USA
    J Biol Chem 284:30615-26. 2009
    ..These data suggest that MMP-25 plays an important role in MS pathology and that MMP-25, especially because of its restricted cell/tissue expression pattern and cell surface/lipid raft localization, is a promising drug target in MS...
  23. pmc Structural determinants of limited proteolysis
    Marat D Kazanov
    Sanford Burnham Medical Research Institute, 10901 North Torrey Pines Road, La Jolla, California 92037, USA
    J Proteome Res 10:3642-51. 2011
    ..Overall, this study provided a foundation for accurate automated prediction of segments of protein structure susceptible to proteolytic processing and, potentially, other post-translational modifications...
  24. pmc Proteins and an inflammatory network expressed in colon tumors
    Wenhong Zhu
    Sanford Burnham Medical Research Institute, 10901 North Torrey Pines Rd, La Jolla, California 92037, United States
    J Proteome Res 10:2129-39. 2011
    ..0056). This study provides new insights into the proteins and networks that are likely to drive the onset and progression of colon cancer...
  25. pmc Central carbon metabolism in the progression of mammary carcinoma
    Adam D Richardson
    The Cancer Center, The Burnham Institute for Medical Research, La Jolla, CA 92037, USA
    Breast Cancer Res Treat 110:297-307. 2008
    ..This work provides the first comprehensive view of changes to central metabolism as a result of breast tumor progression...
  26. pmc PMAP: databases for analyzing proteolytic events and pathways
    Yoshinobu Igarashi
    The Center on Proteolytic Pathways, The Cancer Research Center and The Inflammatory and Infectious Disease Center, The Burnham Institute for Medical Research, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA
    Nucleic Acids Res 37:D611-8. 2009
    ..Here, we describe how the databases of PMAP can be used to foster understanding of proteolytic pathways, and equally as significant, to reason about proteolysis...
  27. pmc Functional specialization in proline biosynthesis of melanoma
    Jessica De Ingeniis
    Sanford Burnham Medical Research Institute, La Jolla, California, United States of America
    PLoS ONE 7:e45190. 2012
    ..PYCRL, localized in the cytosol, is exclusively linked to the conversion of ornithine to proline. This analysis provides the first clarification of the role of PYCRs to proline biosynthesis...
  28. ncbi request reprint A fatty acid synthase blockade induces tumor cell-cycle arrest by down-regulating Skp2
    Lynn M Knowles
    Cancer Research Center, The Burnham Institute, La Jolla, California 92037, USA
    J Biol Chem 279:30540-5. 2004
    ..Altogether, the findings of the study reveal unappreciated links between fatty acid synthase and ubiquitin-dependent proteolysis of cell-cycle regulatory proteins...
  29. ncbi request reprint A residue in the S2 subsite controls substrate selectivity of matrix metalloproteinase-2 and matrix metalloproteinase-9
    Emily I Chen
    Cancer Research Center, The Burnham Institute, La Jolla, CA 92037, USA
    J Biol Chem 278:17158-63. 2003
    ..The residues that occupy this position in other MMPs are highly variable, providing a potential structural basis for substrate recognition across the MMP family...
  30. ncbi request reprint Redox control of integrin adhesion receptors
    Jeffrey W Smith
    Cancer Research Center, Burnham Institute, La Jolla, California 92037, USA
    Methods Enzymol 353:156-63. 2002
  31. ncbi request reprint Maspin alters the carcinoma proteome
    Emily I Chen
    Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, California 92037, USA
    FASEB J 19:1123-4. 2005
    ..These observations reveal for the first time the far reaching effects of maspin on multiple protein networks and a new hypothesis of maspin function based on the regulation of proteasome function...
  32. pmc One-step fabrication of polymeric Janus nanoparticles for drug delivery
    Hui Xie
    The Sanford Burnham Medical Research Institute, La Jolla, California 92037, United States
    Langmuir 28:4459-63. 2012
    ..To the best of our knowledge, this is the first demonstration of biocompatible Janus nanoparticles that encapsulate a hydrophobic drug (paclitaxel) on one side and a hydrophilic drug (doxorubicin hydrochloride) on the other...
  33. ncbi request reprint Methods for analysis of the integrin ligand binding event
    Jeffrey W Smith
    Burnham Institute, La Jolla, California 92037, USA
    Methods Cell Biol 69:247-59. 2002
  34. ncbi request reprint Novel antagonists of the thioesterase domain of human fatty acid synthase
    Robyn D Richardson
    Cancer Research Center and Center on Proteolytic Pathways, Burnham Institute for Medical Research, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA
    Mol Cancer Ther 6:2120-6. 2007
    ..This set of novel FAS antagonists provides an important pharmacologic lead for further development of anticancer therapeutics...
  35. pmc High throughput substrate phage display for protease profiling
    Boris Ratnikov
    Center on Proteolytic Pathways, Burnham Institute for Medical Research, La Jolla, CA, USA
    Methods Mol Biol 539:93-114. 2009
    ..The semiautomated platform allows one to obtain an order of magnitude more data, thus permitting precise comparisons among related proteases to define their functional distinctions...
  36. pmc Comparative metabolic flux profiling of melanoma cell lines: beyond the Warburg effect
    David A Scott
    Cancer Research Center, Sanford Burnham Medical Research Institute, La Jolla, California 92037, USA
    J Biol Chem 286:42626-34. 2011
    ..Altogether, this study, which is the first comprehensive comparative analysis of metabolism in melanoma cells, provides a foundation for targeting metabolism for therapeutic benefit in melanoma...
  37. ncbi request reprint A unique substrate binding mode discriminates membrane type-1 matrix metalloproteinase from other matrix metalloproteinases
    Steven J Kridel
    Program on Cell Adhesion, The Cancer Research Center, The Burnham Institute, La Jolla, California 92037, USA
    J Biol Chem 277:23788-93. 2002
    ..Altogether the study provides a structural basis for selective and non-selective substrate recognition by MT1-MMP. The findings in this report are likely to explain several aspects of MT1-MMP biology...
  38. ncbi request reprint S-nitrosylation of matrix metalloproteinases: signaling pathway to neuronal cell death
    Zezong Gu
    Center for Neuroscience and Aging, Program in Cell Adhesion and Extracellular Matrix Biology, The Burnham Institute, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA
    Science 297:1186-90. 2002
    ..These findings suggest a potential extracellular proteolysis pathway to neuronal cell death in which S-nitrosylation activates MMPs, and further oxidation results in a stable posttranslational modification with pathological activity...
  39. pmc Polymer particle shape independently influences binding and internalization by macrophages
    Gaurav Sharma
    Sanford Burnham Medical Research Institute, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA
    J Control Release 147:408-12. 2010
    ..The results of the study also give mechanistic guidance on how particle shape can be manipulated to design drug carriers to evade macrophages, or alternatively to target macrophages...
  40. pmc Profiling constitutive proteolytic events in vivo
    John C Timmer
    Burnham Institute for Medical Research, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA
    Biochem J 407:41-8. 2007
    ..Taken together, our results demonstrate how to rapidly distinguish real proteolysis that occurs in vivo from the predictions based on in vitro experiments...
  41. ncbi request reprint Inhibition of endothelial cell proliferation and angiogenesis by orlistat, a fatty acid synthase inhibitor
    Cecille D Browne
    Cancer Research Center, Burnham Institute for Medical Research, 10901 North Torrey Pines Rd, La Jolla, CA 92037, USA
    FASEB J 20:2027-35. 2006
    ..Thus, orlistat is an antiangiogenic agent with a novel mechanism of action...
  42. ncbi request reprint Orlistat is a novel inhibitor of fatty acid synthase with antitumor activity
    Steven J Kridel
    Cancer Research Center, The Burnham Institute, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA
    Cancer Res 64:2070-5. 2004
    ..By virtue of its ability to inhibit fatty acid synthase, Orlistat halts tumor cell proliferation, induces tumor cell apoptosis, and inhibits the growth of PC-3 tumors in nude mice...
  43. pmc Efficient synthetic inhibitors of anthrax lethal factor
    Martino Forino
    Burnham Institute, Cancer Research Center and Infectious and Inflammatory Disease Center, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 102:9499-504. 2005
    ..Our data strongly indicate that the scaffold of inhibitors we have identified is the foundation for the development of novel, safe, and effective emergency therapy of postexposure inhalation anthrax...
  44. ncbi request reprint A novel variant of ileal bile acid binding protein is up-regulated through nuclear factor-kappaB activation in colorectal adenocarcinoma
    Changming Fang
    Cancer Research Center, Burnham Institute for Medical Research, La Jolla, California 92037, USA
    Cancer Res 67:9039-46. 2007
    ..Collectively, the studies point toward a unique bile acid response pathway involving NF-kappaB and IBABP-L that could be useful for diagnosis and could potentially be targeted for therapeutic benefit...
  45. pmc CutDB: a proteolytic event database
    Yoshinobu Igarashi
    Burnham Institute for Medical Research, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA
    Nucleic Acids Res 35:D546-9. 2007
    ..CutDB is publicly available at http://cutdb.burnham.org...
  46. ncbi request reprint An alternative processing of integrin alpha(v) subunit in tumor cells by membrane type-1 matrix metalloproteinase
    Boris I Ratnikov
    Burnham Institute, 10901 N Torrey Pines Road, La Jolla, California 92037, USA
    J Biol Chem 277:7377-85. 2002
    ....
  47. pmc Mass spectrometry-based label-free quantitative proteomics
    Wenhong Zhu
    Center on Proteolytic Pathways, Burnham Institute for Medical Research, 10901 N Torrey Pines Road, La Jolla, CA 92037, USA
    J Biomed Biotechnol 2010:840518. 2010
    ..In this paper, we will discuss the technologies of these label-free quantitative methods, statistics, available computational software, and their applications in complex proteomics studies...
  48. ncbi request reprint Gene expression profiling of tumor xenografts: In vivo analysis of organ-specific metastasis
    Hyerim Lee
    The Cancer Research Center, Program on Cell Adhesion at The Burnham Institute, La Jolla, CA 92037, USA
    Int J Cancer 107:528-34. 2003
    ..This raises the hypothesis that tumors preferentially metastasize to lymph nodes by using CD73 to mimic part of the lymphocyte homing process...
  49. doi request reprint Beta-lactam congeners of orlistat as inhibitors of fatty acid synthase
    Wei Zhang
    Department of Chemistry, Texas A and M University, College Station, TX 77842 3012, USA
    Bioorg Med Chem Lett 18:2491-4. 2008
    ..While in general these derivatives showed lower potency compared to beta-lactones, a reasonably potent, lead compound (-)-9 (IC(50)=8.6microM) was discovered that suggests that this class of compounds should be evaluated further...
  50. ncbi request reprint Total synthesis and comparative analysis of orlistat, valilactone, and a transposed orlistat derivative: Inhibitors of fatty acid synthase
    Gil Ma
    Department of Chemistry, Texas A and M University, College Station, Texas 77842 3012, USA
    Org Lett 8:4497-500. 2006
    ..Comparative antagonistic activity of these derivatives toward a recombinant form of the thioesterase domain of fatty acid synthase is reported along with comparative activity-based profiling...
  51. ncbi request reprint Practical, catalytic, asymmetric synthesis of beta-lactones via a sequential ketene dimerization/hydrogenation process: inhibitors of the thioesterase domain of fatty acid synthase
    Vikram C Purohit
    Department of Chemistry, Texas A and M University, P O Box 30012, College Station, Texas 77842 3012, USA
    J Org Chem 71:4549-58. 2006
    ..28 +/- 0.06 microM). In addition, mechanistic studies of the ketene dimerization process by ReactionView infrared spectroscopy support previous findings that ketene formation is rate determining...
  52. doi request reprint HTS identifies novel and specific uncompetitive inhibitors of the two-component NS2B-NS3 proteinase of West Nile virus
    Paul A Johnston
    Pittsburgh Molecular Library Screening Center, Department of Pharmacology, University of Pittsburgh Drug Discovery Institute, University of Pittsburgh, Pittsburgh, PA 15260, USA
    Assay Drug Dev Technol 5:737-50. 2007
    ..We also provide the structural basis for additional species-selective allosteric inhibitors of flaviviruses...
  53. ncbi request reprint Hypercalcemia
    Michelle M Shepard
    Department of Internal Medicine, Division of Nephrology, Medical University of South Carolina, Charleston, South Carolina 29425, USA
    Am J Med Sci 334:381-5. 2007
    ..Calcium stores, serum measurement, and regulation are reviewed as an introduction to understanding the etiology and treatment of hypercalcemia...

Research Grants37

  1. A Variant of Ileal Bile Acid Binding Protein in Colon Cancer
    Jeffrey Smith; Fiscal Year: 2006
    ....
  2. Vascular Integrins and Nitric Oxide
    Jeffrey Smith; Fiscal Year: 2007
    ..abstract_text> ..
  3. Metalloproteinases in Tumor Progression and Metastasis
    Jeffrey Smith; Fiscal Year: 2007
    ..These chemical leads will be improved by iterative structure-based modifications and will be tested in cell-based assays and ultimately in animal models of tumor progression. ..
  4. Center on Proteolytic Pathways(RMI)
    Jeffrey Smith; Fiscal Year: 2007
    ..An Outreach component is planned to ensure that the CPP achieves high visibility, and ultimately numerous connections, with the scientific research community. ..
  5. Nanotherapy for Vulnerable Plaque
    Jeffrey Smith; Fiscal Year: 2007
    ..abstract_text> ..
  6. Metalloproteinases in Tumor Progression and Metastasis
    Jeffrey Smith; Fiscal Year: 2009
    ..These chemical leads will be improved by iterative structure-based modifications and will be tested in cell-based assays and ultimately in animal models of tumor progression. ..
  7. FXR signaling pathway is a valid target for chemoprevention in colorectal cancer
    Jeffrey Smith; Fiscal Year: 2009
    ..Results from this study are likely to provide new methods for chemoprevention, and novel assays for identifying responsive sub-populations. ..
  8. Applied Biosystems QStar Pulsar I with oMALDI Source
    Jeffrey Smith; Fiscal Year: 2003
    ..The acquisition of the Q-Star instrument will enhance the Burnham Institute's broad, long-term effort of supporting and enabling world-class science at the interface of biology and mass spectrometry. ..
  9. ALPHA V INTEGRINS IN BREAST CANCER
    Jeffrey Smith; Fiscal Year: 2002
    ..Results from these analyses will greatly augment the interpretation of results obtained from the experiments on tumor metastasis. ..
  10. MECHANISM OF ACTIVATION OF PLATELET GPIIB AND GPIIIA
    Jeffrey Smith; Fiscal Year: 2001
    ..Binding studies will be performed between Ca2+ and purified conformers of dormant and active IIb-IIIa. Results from this analysis should determine which class of ion binding sites regulate activation of the integrin. ..
  11. DISINTEGRINS & METALLOPROTEINASES IN ORTHOPEDIC DISEASE
    Jeffrey Smith; Fiscal Year: 2002
    ..Homology-based PCR will be used to clone osteoclast ADAMs. Antibodies against these ADAMs will be used in attempts to block osteoclast differentiation. ..