J D Smith

Summary

Affiliation: The Rockefeller University
Country: USA

Publications

  1. ncbi request reprint Human apolipoprotein E allele-specific brain expressing transgenic mice
    J D Smith
    Laboratory of Biochemical Genetics and Metabolism, The Rockefeller University, New York, NY 10021, USA
    Neurobiol Aging 19:407-13. 1998
  2. ncbi request reprint Apolipoprotein E4: an allele associated with many diseases
    J D Smith
    Laboratory of Biomedical Genetics and Metabolism, The Rockefeller University, New York, NY 10021, USA
    Ann Med 32:118-27. 2000
  3. ncbi request reprint Effect of estradiol on neuronal Swedish-mutated beta-amyloid precursor protein metabolism: reversal by astrocytic cells
    B Vincent
    Laboratory of Biochemical Genetics and Metabolism, Rockefeller University, 1230 York Avenue, New York, New York 10021, USA
    Biochem Biophys Res Commun 271:82-5. 2000
  4. ncbi request reprint Genetic background determines the extent of atherosclerosis in ApoE-deficient mice
    H M Dansky
    Laboratory of Biochemical Genetics, Rockefeller University, New York, NY 10021, USA
    Arterioscler Thromb Vasc Biol 19:1960-8. 1999
  5. ncbi request reprint Astrocytes down-regulate neuronal beta-amyloid precursor protein expression and modify its processing in an apolipoprotein E isoform-specific manner
    B Vincent
    Laboratory of Biochemical Genetics and Metabolism, The Rockefeller University, 1230 York Avenue, New York, NY 10021, USA
    Eur J Neurosci 14:256-66. 2001
  6. ncbi request reprint Genetic modifiers of atherosclerosis in mice
    J D Smith
    The Rockefeller University, New York, New York 10021, USA
    Ann N Y Acad Sci 947:247-52; discussion 252-3. 2001
  7. ncbi request reprint Stably transfected ABCA1 antisense cell line has decreased ABCA1 mRNA and cAMP-induced cholesterol efflux to apolipoprotein AI and HDL
    P Zheng
    The Rockefeller University, 1230 York Avenue, New York, NY 10021, USA
    Biochim Biophys Acta 1534:121-8. 2001
  8. pmc Apo A-I inhibits foam cell formation in Apo E-deficient mice after monocyte adherence to endothelium
    H M Dansky
    Laboratory of Biochemical Genetics and Metabolism, The Rockefeller University, New York, New York 10021, USA
    J Clin Invest 104:31-9. 1999
  9. ncbi request reprint Further characterization of the metabolic properties of triglyceride-rich lipoproteins from human and mouse apoC-III transgenic mice
    K Aalto-Setala
    Laboratory of Biochemical Genetics and Metabolism, Rockefeller University, New York, NY 10021 6399, USA
    J Lipid Res 37:1802-11. 1996
  10. pmc Targeted disruption of the class B scavenger receptor CD36 protects against atherosclerotic lesion development in mice
    M Febbraio
    Department of Medicine, Division of Hematology and Medical Oncology, Center of Vascular Biology, Weill Medical College of Cornell University, New York, New York 10021, USA
    J Clin Invest 105:1049-56. 2000

Collaborators

Detail Information

Publications19

  1. ncbi request reprint Human apolipoprotein E allele-specific brain expressing transgenic mice
    J D Smith
    Laboratory of Biochemical Genetics and Metabolism, The Rockefeller University, New York, NY 10021, USA
    Neurobiol Aging 19:407-13. 1998
    ..Aged apoE4 transgenic mouse brain failed to demonstrate any evidence of senile plaques. These mice may be useful for elucidation of the mechanism by which apoE4 is associated with Alzheimer's disease...
  2. ncbi request reprint Apolipoprotein E4: an allele associated with many diseases
    J D Smith
    Laboratory of Biomedical Genetics and Metabolism, The Rockefeller University, New York, NY 10021, USA
    Ann Med 32:118-27. 2000
    ..The apoE polymorphism also affects response to head trauma, cognitive decline upon ageing and several other disorders. Thus, common genetic variation in the apoE gene may be associated with successful ageing...
  3. ncbi request reprint Effect of estradiol on neuronal Swedish-mutated beta-amyloid precursor protein metabolism: reversal by astrocytic cells
    B Vincent
    Laboratory of Biochemical Genetics and Metabolism, Rockefeller University, 1230 York Avenue, New York, New York 10021, USA
    Biochem Biophys Res Commun 271:82-5. 2000
    ..Altogether, our data indicate that astrocytes interfere with estrogen in the regulation of sAPPalpha secretion, probably via secreted factor(s)...
  4. ncbi request reprint Genetic background determines the extent of atherosclerosis in ApoE-deficient mice
    H M Dansky
    Laboratory of Biochemical Genetics, Rockefeller University, New York, NY 10021, USA
    Arterioscler Thromb Vasc Biol 19:1960-8. 1999
    ..Thus, a genomic approach may succeed in identifying the genes responsible for the variation in atherosclerosis susceptibility in these 2 strains of ApoE-deficient mice, which could not be explained by measured plasma parameters...
  5. ncbi request reprint Astrocytes down-regulate neuronal beta-amyloid precursor protein expression and modify its processing in an apolipoprotein E isoform-specific manner
    B Vincent
    Laboratory of Biochemical Genetics and Metabolism, The Rockefeller University, 1230 York Avenue, New York, NY 10021, USA
    Eur J Neurosci 14:256-66. 2001
    ..Thus, apoE and astrocytic factor(s) may modulate the pathogenesis of Alzheimer's disease...
  6. ncbi request reprint Genetic modifiers of atherosclerosis in mice
    J D Smith
    The Rockefeller University, New York, New York 10021, USA
    Ann N Y Acad Sci 947:247-52; discussion 252-3. 2001
    ..We have performed quantitative trait locus mapping on two F2 cohorts and discovered atherosclerosis susceptibility loci on chromosomes 10, 14, and 19...
  7. ncbi request reprint Stably transfected ABCA1 antisense cell line has decreased ABCA1 mRNA and cAMP-induced cholesterol efflux to apolipoprotein AI and HDL
    P Zheng
    The Rockefeller University, 1230 York Avenue, New York, NY 10021, USA
    Biochim Biophys Acta 1534:121-8. 2001
    ..These data demonstrate that ABCA1 is necessary for the cAMP-induced lipid efflux to both apoAI and HDL...
  8. pmc Apo A-I inhibits foam cell formation in Apo E-deficient mice after monocyte adherence to endothelium
    H M Dansky
    Laboratory of Biochemical Genetics and Metabolism, The Rockefeller University, New York, New York 10021, USA
    J Clin Invest 104:31-9. 1999
    ....
  9. ncbi request reprint Further characterization of the metabolic properties of triglyceride-rich lipoproteins from human and mouse apoC-III transgenic mice
    K Aalto-Setala
    Laboratory of Biochemical Genetics and Metabolism, Rockefeller University, New York, NY 10021 6399, USA
    J Lipid Res 37:1802-11. 1996
    ..This could explain the predicted functional lipase deficiency in apoC-III transgenic mice based on the observation of a prolonged residence time of enlarged triglyceride-rich lipoproteins...
  10. pmc Targeted disruption of the class B scavenger receptor CD36 protects against atherosclerotic lesion development in mice
    M Febbraio
    Department of Medicine, Division of Hematology and Medical Oncology, Center of Vascular Biology, Weill Medical College of Cornell University, New York, New York 10021, USA
    J Clin Invest 105:1049-56. 2000
    ..These results support a major role for CD36 in atherosclerotic lesion development in vivo and suggest that blockade of CD36 can be protective even in more extreme proatherogenic circumstances...
  11. pmc Combined hyperlipidemia in transgenic mice overexpressing human apolipoprotein Cl
    N S Shachter
    Department of Medicine, College of Physicians and Surgeons of Columbia University, New York, New York 10032, USA
    J Clin Invest 98:846-55. 1996
    ....
  12. ncbi request reprint Promoter polymorphisms of hepatic lipase gene influence HDL(2) but not HDL(3) in African American men: CARDIA study
    S H Juo
    Columbia Genome Center, Columbia University, New York, NY 10032, USA
    J Lipid Res 42:258-64. 2001
    ..The change of the anthropometric variables was not significantly associated with genotypes. In conclusion, our results indicated that the LIPC promoter polymorphism has exclusive effects on HDL(2)-C but not HDL(3)-C levels...
  13. pmc Cytochrome P450 1A1 promoter as a genetic switch for the regulatable and physiological expression of a plasma protein in transgenic mice
    J D Smith
    Laboratory of Biochemical Genetics and Metabolism, Rockefeller University, New York, NY 10021, USA
    Proc Natl Acad Sci U S A 92:11926-30. 1995
    ..These finding suggest a strategy to temporarily ameliorate genetic deficiencies that would otherwise lead to fetal or neonatal lethality...
  14. pmc Decreased atherosclerosis in mice deficient in both macrophage colony-stimulating factor (op) and apolipoprotein E
    J D Smith
    Laboratory of Biochemical Genetics and Metabolism, Rockefeller University, New York, NY 10021, USA
    Proc Natl Acad Sci U S A 92:8264-8. 1995
    ..The data support the hypothesis that macrophage colony-stimulating factor and its effects on macrophage development and function play a key role in atherogenesis...
  15. ncbi request reprint Scavenger receptor-BI inhibits ATP-binding cassette transporter 1- mediated cholesterol efflux in macrophages
    W Chen
    Division of Molecular Medicine, Department of Medicine, Columbia University, New York, New York 10032, USA
    J Biol Chem 275:30794-800. 2000
    ..SR-BI and ABC1 appear to have distinct and competing roles in mediating cholesterol flux between HDL and macrophages. In nonpolarized cells, SR-BI promotes the reuptake of cholesterol actively effluxed by ABC1, creating a futile cycle...
  16. ncbi request reprint Identification of cAMP analogue inducible genes in RAW264 macrophages
    Y Takahashi
    Laboratory of Biochemical Genetics and Metabolism, Box 179, The Rockefeller University, 1230 York Avenue, New York, NY 10021, USA
    Biochim Biophys Acta 1492:385-94. 2000
    ..ABC1 was upregulated in RAW cells by cAMP, concurrent with the cAMP induction of lipid efflux to apolipoprotein A1...
  17. ncbi request reprint Brain region-specific up-regulation of mouse apolipoprotein E by pharmacological estrogen treatments
    J Levin-Allerhand
    The Rockefeller University, New York, New York 10021, USA
    J Neurochem 79:796-803. 2001
    ..Measurement of mRNA levels in estrogen versus placebo-treated wild-type mice indicated that the effect of 17 beta-estradiol on apoE was not associated with changes in apoE mRNA levels...
  18. pmc Lipidation of apolipoprotein E influences its isoform-specific interaction with Alzheimer's amyloid beta peptides
    T Tokuda
    Department of Pathology, New York University School of Medicine, 550 First Avenue, New York, NY 10016, USA
    Biochem J 348:359-65. 2000
    ....
  19. ncbi request reprint Severe hypercholesterolemia and atherosclerosis in apolipoprotein E-deficient mice created by homologous recombination in ES cells
    A S Plump
    Laboratory of Biochemical Genetics and Metabolism, The Rockefeller University, New York, New York 10021 6399
    Cell 71:343-53. 1992
    ..apoE-deficient mice are a promising small animal model to help understand the role of apoE in vivo and the genetic and environmental determinants of atherosclerosis...