DANA M contact SMALL
Affiliation: The John B. Pierce Laboratory
- Gustatory agnosiaD M Small
The John B Pierce Laboratory, Yale University School of Medicine, 290 Congress Avenue, New Haven, CT 06519, USA
Neurology 64:311-7. 2005..To report the assessment of a patient exhibiting gustatory agnosia...
- Central gustatory processing in humansDana M Small
The John B Pierce Laboratory and Yale University, New Haven, CT 06519, USA
Adv Otorhinolaryngol 63:191-220. 2006..The section on the gustatory pathway describes what is known about how taste intensity, quality and affective value are represented in the human brain. The chapter concludes with a review of flavor processing...
- Ventromedial prefrontal cortex response to concentrated sucrose reflects liking rather than sweet quality codingKristin J Rudenga
The John B Pierce Laboratory, 290 Congress Avenue, New Haven, CT 06520, USA
Chem Senses 38:585-94. 2013..Likers versus dislikers did not differ in their diet, alcohol use, body weight, gender, or taq1A allele status, but likers were more likely to report emotional eating. None of these factors influenced response in the vmPFC. ..
- Sensory neuroscience: taste responses in primary olfactory cortexDana M Small
The John B Pierce Laboratory, 290 Congress Avenue, New Haven, CT 06519, USA
Curr Biol 23:R157-9. 2013..A new electrophysiological study in rodents demonstrates that taste-odor convergence occurs in posterior piriform olfactory cortex and calls for a reformulation of classic models of the central representation of flavor...
- The role of the human orbitofrontal cortex in taste and flavor processingDana M Small
The John B Pierce Laboratory, New Haven, CT 06519, USA
Ann N Y Acad Sci 1121:136-51. 2007..Thus, it is likely that, in addition to serving as higher-order gustatory cortex, the OFC integrates multiple sensory inputs and computes reward value to guide feeding behavior...
- Differential neural responses evoked by orthonasal versus retronasal odorant perception in humansDana M Small
The John B Pierce Laboratory, New Haven, Connecticut 06519, USA
Neuron 47:593-605. 2005..These findings demonstrate differential neural recruitment depending upon the route of odorant administration and suggest that its effect is influenced by whether an odorant represents a food...
- Separable substrates for anticipatory and consummatory food chemosensationDana M Small
John B Pierce Laboratory, New Haven, CT 06519, USA
Neuron 57:786-97. 2008..Moreover, since ratings of perceived pleasantness of FO+, FO-, and drink were similar, the response in the amygdala and thalamus cannot reflect acquired affective value but rather predictive meaning or biological relevance...
- Monetary incentives enhance processing in brain regions mediating top-down control of attentionDana M Small
Northwestern University Brain Mapping Group and Cognitive Neurology and Alzheimer s Disease Center, Chicago, IL 60611, USA
Cereb Cortex 15:1855-65. 2005..They also show that different cognitive and motivational mechanisms may produce a common effect upon unimodal cortices in order to enhance processing to serve the current behavioral goal...
- Experience-dependent neural integration of taste and smell in the human brainDana M Small
Cognitive Neurology and Alzheimer s Disease Center, Northwestern University Feinberg School of Medicine, Chicago, IL 60611 3008, USA
J Neurophysiol 92:1892-903. 2004....
- Individual differences in the neurophysiology of reward and the obesity epidemicD M Small
The John B Pierce Laboratory, Department of Psychiatry, Yale University School of Medicine, New Haven, CT 06519, USA
Int J Obes (Lond) 33:S44-8. 2009..The aim of this review is to highlight several possible ways by which individual differences in the neurophysiology of food reward may lead to overeating...
- Taste representation in the human insulaDana M Small
The John B Pierce Laboratory, 290 Congress Avenue, New Haven, CT 06519, USA
Brain Struct Funct 214:551-61. 2010....
- Changes in brain activity related to eating chocolate: from pleasure to aversionD M Small
Neuropsychology Cognitive Neuroscience Unit, and Northwestern Cognitive Brain Mapping Group, Northwestern University School of Medicine, Chicago, IL 60611, USA
Brain 124:1720-33. 2001..Therefore, these results support the hypothesis that there are two separate motivational systems: one orchestrating approach and another avoidance behaviours...
- Increased intensity perception of aversive taste following right anteromedial temporal lobe removal in humansD M Small
Northwestern Brain Mapping Group, Northwestern University Medical School, Chicago, Illinois 60611, USA
Brain 124:1566-75. 2001..This finding complements existing literature indicating that the AMTL is important for processing aversive taste, and suggests that inhibitory mechanisms may play an important role in such processing...
- Toward an understanding of the brain substrates of reward in humansDana M Small
Cognitive Neurology and Alzheimer s Disease Center, Northwestern University Medical School, 320 East Superior, Searle 11 465, Chicago, IL 60611, USA
Neuron 33:668-71. 2002..now provide evidence that this network is differentially modulated by anticipation versus receipt of a food reward and suggest an additional effect of valence of the stimulus...
- Dissociation of neural representation of intensity and affective valuation in human gustationDana M Small
Cognitive Neurology and Alzheimer s Disease Center, Northwestern University Feinberg Medical School, 320 East Superior Street, Chicago, IL 60611, USA
Neuron 39:701-11. 2003..They also show that amygdala activity may be driven by stimulus intensity irrespective of valence, casting doubt upon the notion that the amygdala responds preferentially to negative stimuli...
- How does food's appearance or smell influence the way it tastes?Dana M Small
Sci Am 299:100. 2008
- Modulation of the spatial attention network by incentives in healthy aging and mild cognitive impairmentLisa A Bagurdes
Cognitive Neurology and Alzheimer s Disease Center, Northwestern University Feinberg School of Medicine, United States
Neuropsychologia 46:2943-8. 2008..These results suggest a reorganization of the relationships between the limbic system and spatial attention network in healthy aging and MCI...
- Odor/taste integration and the perception of flavorDana M Small
The John B Pierce Laboratory and Section of Otolaryngology, Yale University School of Medicine, 290 Congress Avenue, New Haven, CT 06519, USA
Exp Brain Res 166:345-57. 2005....
- Trying to detect taste in a tasteless solution: modulation of early gustatory cortex by attention to tasteMaria G Veldhuizen
Affective Sensory Neuroscience, The John B Pierce Laboratory, 290 Congress Avenue, New Haven, CT 06519, USA
Chem Senses 32:569-81. 2007....
- Taste and olfactory intensity perception changes following left insular strokeY Erica Mak
The John B Pierce Laboratory, Yale University School of Medicine, New Haven, CT 06519, USA
Behav Neurosci 119:1693-700. 2005..These results show that a left posterior insula lesion may affect taste and olfactory perception similarly by increasing sensitivity contralateral to the lesion. One possible mechanism is release from inhibition at the cortical level...
- Sleep deprivation alters functioning within the neural network underlying the covert orienting of attentionBryce A Mander
Department of Neurology, Northwestern University, Feinberg School of Medicine, Chicago, IL 60611, USA
Brain Res 1217:148-56. 2008..These changes may render sleep-deprived individuals less able to anticipate the locations of upcoming events, and more susceptible to distraction by stimuli at irrelevant locations...
- Feeding-induced dopamine release in dorsal striatum correlates with meal pleasantness ratings in healthy human volunteersDana M Small
McConnell Brain Imaging Center, Montreal Neurological Institute and McGill University, 3801 University Street, Montreal, Quebec, Canada H3A 2B4
Neuroimage 19:1709-15. 2003..These results suggest that feeding is associated with dopamine release in the dorsal, but not the ventral striatum, and that the amount of dopamine released correlates with the degree of experienced pleasure...
- Increased taste intensity perception exhibited by patients with chronic back painDana M Small
The John B Pierce Laboratory, Yale University, New Haven, CT, USA
Pain 120:124-30. 2006..e. increased sensitivity). The selectivity of the taste disturbance suggests interaction between pain and taste at specific brain sites and provides further evidence that CBP involves specific brain abnormalities...
- Neural substrates of taste, smell and flavor in humansDANA SMALL; Fiscal Year: 2006..g., Alzheimer's disease) or patients who may respond abnormally to food stimuli (e.g., bulimia). This research will also provide important information into the nature of polymodal sensory integration. ..
- Interactions Between Nicotine Addiction and Food RewardDANA SMALL; Fiscal Year: 2006..If brain response does predict weight gain then we will have developed a method to identify individuals at risk for relapse so that they can be targeted for further therapeutic intervention. ..
- Cognitive and affective influences on taste processingDANA SMALL; Fiscal Year: 2007..This research will provide fundamental information about human gustation and it will provide important baseline data for future studies of gustatory processing in the obese and individuals with an eating, drug or alcohol disorder. ..
- The role of the amygdala in weight gain susceptibilityDANA M contact SMALL; Fiscal Year: 2010....
- Cognitive and affective influences on taste processingDana M Small; Fiscal Year: 2010..This research will provide fundamental information about human gustation and it will provide important baseline data for future studies of gustatory processing in the obese and individuals with an eating, drug or alcohol disorder. ..