Brian M Slomovitz

Summary

Affiliation: The University of Texas
Country: USA

Publications

  1. ncbi request reprint Prophylactic surgery to reduce the risk of gynecologic cancers in the Lynch syndrome
    Kathleen M Schmeler
    Department of Gynecologic Oncology, The University of Texas M D Anderson Cancer Center, Houston, TX 77230 1439, USA
    N Engl J Med 354:261-9. 2006
  2. ncbi request reprint Are women ready for the HPV vaccine?
    Brian M Slomovitz
    Department of Gynecologic Oncology, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Gynecol Oncol 103:151-4. 2006
  3. ncbi request reprint Prophylactic bilateral salpingo-oophorectomy compared with surveillance in women with BRCA mutations
    Kathleen M Schmeler
    Department of Gynecologic Oncology, University of Texas MD Anderson Cancer Center, Houston, Texas 77230, USA
    Obstet Gynecol 108:515-20. 2006
  4. doi request reprint A prospective phase II study of chemoradiation followed by adjuvant chemotherapy for FIGO stage I-IIIA (1988) uterine papillary serous carcinoma of the endometrium
    Anuja Jhingran
    Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
    Gynecol Oncol 129:304-9. 2013
  5. ncbi request reprint Women with synchronous primary cancers of the endometrium and ovary: do they have Lynch syndrome?
    Pamela T Soliman
    Department of Gynecologic Oncology, University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    J Clin Oncol 23:9344-50. 2005
  6. ncbi request reprint Imatinib mesylate (gleevec)--targeted kinases are expressed in uterine sarcomas
    Jimmy J Caudell
    Department of Gynecologic Oncology, The University of Texas M D Anderson Cancer Center, Houston, TX 77030 4009, USA
    Appl Immunohistochem Mol Morphol 13:167-70. 2005
  7. doi request reprint Efficacy of letrozole in the treatment of recurrent platinum- and taxane-resistant high-grade cancer of the ovary or peritoneum
    Pedro T Ramirez
    Department of Gynecologic Oncology, The University of Texas M D Anderson Cancer Center, Houston, TX 77230 1439, USA
    Gynecol Oncol 110:56-9. 2008
  8. doi request reprint A phase 2 study of the oral mammalian target of rapamycin inhibitor, everolimus, in patients with recurrent endometrial carcinoma
    Brian M Slomovitz
    Department of Gynecologic Oncology, The University of Texas M D Anderson Cancer Center, Houston, Texas, USA
    Cancer 116:5415-9. 2010
  9. ncbi request reprint Comparison of total laparoscopic and abdominal radical hysterectomy for patients with early-stage cervical cancer
    Michael Frumovitz
    Department of Gynecologic Oncology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Obstet Gynecol 110:96-102. 2007
  10. doi request reprint Loss of tuberous sclerosis complex-2 function and activation of mammalian target of rapamycin signaling in endometrial carcinoma
    Karen H Lu
    Department of Gynecologic Oncology, The University of Texas M D Anderson Cancer Center, Smithville, Texas 78957, USA
    Clin Cancer Res 14:2543-50. 2008

Detail Information

Publications34

  1. ncbi request reprint Prophylactic surgery to reduce the risk of gynecologic cancers in the Lynch syndrome
    Kathleen M Schmeler
    Department of Gynecologic Oncology, The University of Texas M D Anderson Cancer Center, Houston, TX 77230 1439, USA
    N Engl J Med 354:261-9. 2006
    ..We designed this study to determine the reduction in the risk of gynecologic cancers associated with prophylactic hysterectomy and bilateral salpingo-oophorectomy in women with the Lynch syndrome...
  2. ncbi request reprint Are women ready for the HPV vaccine?
    Brian M Slomovitz
    Department of Gynecologic Oncology, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Gynecol Oncol 103:151-4. 2006
    ..Because vaccination for both boys and girls will be critical to reduce the incidence of this disease, we evaluated the willingness of women to accept the HPV vaccine and to consent to having their children vaccinated...
  3. ncbi request reprint Prophylactic bilateral salpingo-oophorectomy compared with surveillance in women with BRCA mutations
    Kathleen M Schmeler
    Department of Gynecologic Oncology, University of Texas MD Anderson Cancer Center, Houston, Texas 77230, USA
    Obstet Gynecol 108:515-20. 2006
    ..The objective of this study was to evaluate clinical factors associated with choosing prophylactic bilateral salpingo-oophorectomy (BSO) over surveillance in women with a BRCA1 or BRCA2 mutation...
  4. doi request reprint A prospective phase II study of chemoradiation followed by adjuvant chemotherapy for FIGO stage I-IIIA (1988) uterine papillary serous carcinoma of the endometrium
    Anuja Jhingran
    Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
    Gynecol Oncol 129:304-9. 2013
    ....
  5. ncbi request reprint Women with synchronous primary cancers of the endometrium and ovary: do they have Lynch syndrome?
    Pamela T Soliman
    Department of Gynecologic Oncology, University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    J Clin Oncol 23:9344-50. 2005
    ..The purpose of our study was to determine the likelihood of MMR defects (MSH2, MSH6, MLH1) in women with synchronous endometrial and ovarian cancer...
  6. ncbi request reprint Imatinib mesylate (gleevec)--targeted kinases are expressed in uterine sarcomas
    Jimmy J Caudell
    Department of Gynecologic Oncology, The University of Texas M D Anderson Cancer Center, Houston, TX 77030 4009, USA
    Appl Immunohistochem Mol Morphol 13:167-70. 2005
    ..These results indicate that many uterine sarcomas express 1 or more of the kinases targeted by imatinib mesylate and that further investigation of imatinib as a therapy for uterine sarcomas is warranted...
  7. doi request reprint Efficacy of letrozole in the treatment of recurrent platinum- and taxane-resistant high-grade cancer of the ovary or peritoneum
    Pedro T Ramirez
    Department of Gynecologic Oncology, The University of Texas M D Anderson Cancer Center, Houston, TX 77230 1439, USA
    Gynecol Oncol 110:56-9. 2008
    ..To evaluate the efficacy and safety of letrozole in patients with recurrent platinum- and taxane-resistant estrogen receptor-positive (ER+) high-grade cancer of the ovary or peritoneum...
  8. doi request reprint A phase 2 study of the oral mammalian target of rapamycin inhibitor, everolimus, in patients with recurrent endometrial carcinoma
    Brian M Slomovitz
    Department of Gynecologic Oncology, The University of Texas M D Anderson Cancer Center, Houston, Texas, USA
    Cancer 116:5415-9. 2010
    ..Loss of PTEN or activation of PIK3CA results in constitutive activation of AKT, which leads to up-regulation of mammalian target of rapamycin (mTOR). Everolimus is an oral rapamycin analog that acts by selectively inhibiting mTOR...
  9. ncbi request reprint Comparison of total laparoscopic and abdominal radical hysterectomy for patients with early-stage cervical cancer
    Michael Frumovitz
    Department of Gynecologic Oncology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Obstet Gynecol 110:96-102. 2007
    ..To compare intraoperative, pathologic, and postoperative outcomes of total laparoscopic radical hysterectomy with abdominal radical hysterectomy and pelvic lymphadenectomy for women with early-stage cervical cancer...
  10. doi request reprint Loss of tuberous sclerosis complex-2 function and activation of mammalian target of rapamycin signaling in endometrial carcinoma
    Karen H Lu
    Department of Gynecologic Oncology, The University of Texas M D Anderson Cancer Center, Smithville, Texas 78957, USA
    Clin Cancer Res 14:2543-50. 2008
    ....
  11. ncbi request reprint Role of appendectomy at the time of primary surgery in patients with early-stage ovarian cancer
    Pedro T Ramirez
    Department of Gynecologic Oncology, The University of Texas M D Anderson Cancer Center, PO Box 301439, Unit 1362, Houston, TX 77230 1439, USA
    Gynecol Oncol 103:888-90. 2006
    ..To determine whether appendectomy is warranted in patients with apparent early-stage ovarian cancer who undergo surgery for staging and cytoreduction and to determine the complication rate associated with appendectomy in such patients...
  12. ncbi request reprint Risk factors for young premenopausal women with endometrial cancer
    Pamela T Soliman
    Department of Gynecologic Oncology, The University of Texas M D Anderson Cancer Center, Houston, Texas, USA
    Obstet Gynecol 105:575-80. 2005
    ..The objective of this study was to conduct a clinical and pathologic review of endometrial cancers diagnosed in premenopausal women aged younger than 50 years, to better identify the risk factors for this subgroup of women...
  13. ncbi request reprint Endometrial cancer in young, normal-weight women
    Kathleen M Schmeler
    Department of Gynecologic Oncology, The University of Texas, M D Anderson Cancer Center, PO Box 301439, Unit 1362, Houston, TX 77230 1439, USA
    Gynecol Oncol 99:388-92. 2005
    ..To determine if young, normal-weight women with endometrial cancer have unique risk factors and clinical characteristics when compared with young, overweight and obese women with endometrial cancer...
  14. ncbi request reprint Expression of imatinib mesylate-targeted kinases in endometrial carcinoma
    Brian M Slomovitz
    Department of Gynecologic Oncology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030 4009, USA
    Gynecol Oncol 95:32-6. 2004
    ..To determine whether imatinib mesylate could be a potentially useful agent in the treatment of endometrial cancer, we assessed the expressions of Abl, c-Kit, and PDGFR in both primary and recurrent endometrial carcinoma...
  15. ncbi request reprint Synchronous primary cancers of the endometrium and ovary: a single institution review of 84 cases
    Pamela T Soliman
    Department of Gynecologic Oncology, University of Texas, M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030 4009, USA
    Gynecol Oncol 94:456-62. 2004
    ..The purpose of this study was to characterize patients diagnosed with synchronous primary cancers of the endometrium and ovary with an emphasis on risk factors...
  16. ncbi request reprint Supracervical hysterectomy in patients with advanced epithelial ovarian cancer
    Michael R Milam
    Department of Gynecologic Oncology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Obstet Gynecol 109:641-6. 2007
    ..To assess whether supracervical hysterectomy (SCH) is a reasonable alternative to total abdominal hysterectomy in patients with advanced ovarian cancer...
  17. ncbi request reprint Frozen section analyses as predictors of lymphatic spread in patients with early-stage uterine cancer
    Michael Frumovitz
    Department of Gynecologic Oncology, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
    J Am Coll Surg 199:388-93. 2004
    ..This clinical decision method has never been critically examined...
  18. ncbi request reprint Total laparoscopic radical hysterectomy and lymphadenectomy: the M. D. Anderson Cancer Center experience
    Pedro T Ramirez
    Department of Gynecologic Oncology, The University of Texas M D Anderson Cancer Center, PO Box 301439, Unit 1362, Houston, TX 77230 1439, USA
    Gynecol Oncol 102:252-5. 2006
    ..To retrospectively evaluate the feasibility and morbidity of total laparoscopic radical hysterectomy and lymphadenectomy...
  19. ncbi request reprint Electrothermal bipolar coagulation for pelvic exenterations
    Brian M Slomovitz
    Department of Gynecologic Oncology, The University of Texas M D Anderson Cancer Center, 1155 Pressler Boulevard, Unit 1362, Houston, TX 77030, USA
    Gynecol Oncol 102:534-6. 2006
    ....
  20. ncbi request reprint Reduced progression of endometrial hyperplasia with oral mTOR inhibition in the Pten heterozygote murine model
    Michael R Milam
    Department of Gynecologic Oncology, M D Anderson Cancer Center, Houston, TX 77030, USA
    Am J Obstet Gynecol 196:247.e1-5. 2007
    ..The objective of this study was to evaluate an oral mTOR inhibitor (mTOR-I) on the reduction of endometrial hyperplasia in an animal model...
  21. ncbi request reprint Association between adiponectin, insulin resistance, and endometrial cancer
    Pamela T Soliman
    Department of Gynecologic Oncology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77230 1439, USA
    Cancer 106:2376-81. 2006
    ..The purpose of the current study was to determine whether there was an independent association between adiponectin level and endometrial cancer...
  22. ncbi request reprint Practice patterns of SGO members for stage IIIA endometrial cancer
    Christine M Lee
    Department of Gynecologic Oncology, Division of Surgery, Unit 440, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030 4009, USA
    Gynecol Oncol 98:77-83. 2005
    ..The aim of this study was to survey the Society of Gynecologic Oncologists (SGO) members and fellows about their approach to the treatment of patients with stage IIIA endometrial cancer...
  23. pmc The search continues: looking for predictive biomarkers for response to mammalian target of rapamycin inhibition in endometrial cancer
    Larissa A Meyer
    Departments of Gynecologic Oncology and Reproductive Medicine, Pathology Laboratory Medicine, Biostatistics, and Hematopathology, The University of Texas M D Anderson Cancer Center, Houston, TX
    Int J Gynecol Cancer 24:713-7. 2014
    ..The objective of this study was to determine if biomarker expression in the PI3K/mTOR pathway or KRAS mutations would predict response to therapy with everolimus, an mTOR inhibitor...
  24. ncbi request reprint Does tamoxifen use affect prognosis in breast cancer patients who develop endometrial cancer?
    Brian M Slomovitz
    Department of Gynecologic Oncology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030 4009, USA
    Obstet Gynecol 104:255-60. 2004
    ..The purpose of this study was to estimate whether a history of tamoxifen use is a prognostic factor for such patients...
  25. ncbi request reprint Serous adenocarcinoma of the inguinal region arising from endometriosis followed by a successful pregnancy
    Brian M Slomovitz
    Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, New York Presbyterian Hospital Weill Medical College of Cornell University, New York, NY 10021, USA
    Gynecol Oncol 87:152-4. 2002
    ..Inguinal serous carcinoma arising from endometriosis is an unusual cancer. It is uncertain how patients with these tumors should be managed, especially those patients who desire future fertility...
  26. ncbi request reprint Her-2/neu overexpression and amplification in uterine papillary serous carcinoma
    Brian M Slomovitz
    Department of Gynecologic Oncology, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Blvd, Unit 440, Houston, TX 77030 4009, USA
    J Clin Oncol 22:3126-32. 2004
    ..The purpose of this study was to evaluate the protein expression and gene amplification of Her-2/neu in UPSC and to determine its prognostic value...
  27. ncbi request reprint Coordinate expression of Cdc25B and ER-alpha is frequent in low-grade endometrioid endometrial carcinoma but uncommon in high-grade endometrioid and nonendometrioid carcinomas
    Weiguo Wu
    Department of Gynecologic Oncology, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
    Cancer Res 63:6195-9. 2003
    ..However, in UPSC/CCC, cdc25B is highly expressed without coordinate increase in phosphorylated ER-alpha. Cdc25B may play important roles in the development and progression of EEC and UPSC/CCC by different mechanisms...
  28. doi request reprint The PI3K/AKT/mTOR pathway as a therapeutic target in endometrial cancer
    Brian M Slomovitz
    Morristown Medical Center, Women s Cancer Center, Morristown, New Jersey 07962, USA
    Clin Cancer Res 18:5856-64. 2012
    ..Clinical validation of these findings is ongoing...
  29. ncbi request reprint Methemoglobinemia induced by topical vaginal sulfanilamide cream in a patient with cervical cancer: a case report
    Ian Bristol
    Department of Radiation Oncology, Unit 97, U T M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
    Gynecol Oncol 97:953-6. 2005
    ..The clinical consequences of acute methemoglobinemia can be devastating and include lethargy, headache, and dyspnea and, as methemoglobin concentrations rise, respiratory depression, confusion, seizures, and even death...
  30. ncbi request reprint Uterine papillary serous carcinoma (UPSC): a single institution review of 129 cases
    Brian M Slomovitz
    Department of Gynecologic Oncology, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Gynecol Oncol 91:463-9. 2003
    ..The identified characteristics were then correlated with overall survival (OS)...
  31. ncbi request reprint Development of metastatic endometrial endometrioid adenocarcinoma while on progestin therapy for endometrial hyperplasia
    Jennifer M Rubatt
    Department of Obstetrics and Gynecology, VCUMC Medical College of Virginia, VA 23287, USA
    Gynecol Oncol 99:472-6. 2005
    ..The risk of progression to a high-stage endometrial cancer is quite low, with only two previously reported cases in the English literature...
  32. ncbi request reprint A comparative analysis of 57 serous borderline tumors with and without a noninvasive micropapillary component
    Brian M Slomovitz
    Department of Obstetrics and Gynecology, New York Presbyterian Hospital Weill Medical College of Cornell University, New York, New York, USA
    Am J Surg Pathol 26:592-600. 2002
    ..Stage I MSBTs demonstrate clinical features that are similar to low-stage SBTs. Focal micropapillary architecture (<5 mm) has no bearing on outcome. MSBTs in the general population are not strongly associated with invasive implants...
  33. ncbi request reprint Retroperitoneal lymph node resection in patients with cervical cancer
    Israel Zighelboim
    Division of Gynecologic Oncology, Department of Obstetrics and Gynecology Washington University School of Medicine and Alvin J Siteman Cancer Center, St Louis, MO, USA
    Surg Oncol 15:79-83. 2006
    ..To determine predictive factors precluding complete resection of metastatic lymph nodes identified by pre-operative imaging in patients with cervical cancer...
  34. ncbi request reprint Ovarian mucinous cystadenocarcinoma with virilization
    Farr Nezhat
    Department of Pathology, Mount Sinai Medical Center, New York, New York 10029, USA
    Gynecol Oncol 84:468-72. 2002
    ..Ovarian neoplasms, other than sex cord--stromal tumors, are rare causes of hyperandrogenism. Only two cases of primary mucinous carcinomas associated with virilization have been reported...