Research Topics
| CRAIG SLAWECKISummaryAffiliation: The Scripps Research Institute Country: USA Publications
Research Grants
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Detail Information
Publications
Adolescent vulnerabilities to chronic alcohol or nicotine exposure: findings from rodent modelsSusan Barron
Psychology Department, University of Kentucky, Lexington, KY 40506 0044, USA
Alcohol Clin Exp Res 29:1720-5. 2005..data suggesting that genetic differences could play a role in adolescent vulnerability to ethanol; (3) Craig Slawecki, who presented data looking at the effects of chronic exposure to alcohol or nicotine on neurophysiologic and ..- Comparison of anxiety-like behavior in adolescent and adult Sprague-Dawley ratsCraig J Slawecki
Department of Neuropharmacology, The Scripps Research Institute, La Jolla, CA 92037, USA
Behav Neurosci 119:1477-83. 2005..These studies demonstrate that adolescents display increased anxiety-like behavior when test conditions are more aversive and following exposure to stress... - Exposure to sucrose-quinine solutions does not increase ethanol consumptionC J Slawecki
Department of Physiology and Pharmacology, The Wake Forest University School of Medicine, Winston Salem, NC, USA
Alcohol 16:329-35. 1998..Rather, exposure to taste and postingestive factors associated with ethanol may be necessary to increase ethanol intake... - Comparison of the onset of hypoactivity and anxiety-like behavior during alcohol withdrawal in adolescent and adult ratsCraig J Slawecki
Department of Neuropharmacology, The Scripps Research Institute, La Jolla, California 92037, USA
Alcohol Clin Exp Res 28:598-607. 2004..The objective of these studies was to compare the appearance of ethanol withdrawal-related behaviors in adolescent and adult rats... - Long-term neurobehavioral effects of alcohol or nicotine exposure in adolescent animal modelsCraig J Slawecki
The Scripps Research Institute, Department of Neuropharmacology, CVN14, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
Ann N Y Acad Sci 1021:448-52. 2004..These findings support the hypothesis that adolescents are uniquely susceptible to the effects of chronic alcohol and nicotine exposure... - Electrophysiological effects of allopregnanolone in rats with a history of ethanol exposureCraig J Slawecki
Department of Neuropharmacology, The Scripps Research Institute, La Jolla, California 92037, USA
Alcohol Clin Exp Res 29:66-74. 2005..The purpose of this study was to examine the neurophysiological effects of ALLO in rats with a history of chronic EtOH exposure after a protracted period of abstinence... - Effect of ethanol on brain neuropeptides in adolescent and adult ratsCraig J Slawecki
Scripps Research Institute, Department of Neuropharmacology, CVN 14, 10550 N Torrey Pines Road, La Jolla, California 92307, USA
J Stud Alcohol 66:46-52. 2005..This study assessed the effects of ethanol exposure on several neuropeptides to begin to elucidate potential substrates that could mediate the differential effects of ethanol on adolescent and adult rats... - Neurophysiologic consequences of neonatal ethanol exposure in the ratCraig J Slawecki
The Scripps Research Institute, Department of Neuropharmacology, CVN 14, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
Alcohol 34:187-96. 2004..This neurobehavioral profile in the rat is consistent with clinical observations of attention deficits and hyperactivity in children exposed to ethanol during prenatal development... - Assessment of sustained attention in ad libitum fed Wistar rats: effects of MK-801Craig J Slawecki
The Scripps Research Institute, Department of Neuropharmacology, CVN 14, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
Physiol Behav 85:346-53. 2005..However, evidence indicates that dietary restriction can have profound effects on brain function and on the neurobehavioral effects of drugs... - Increased CRF-like and NPY-like immunoreactivity in adult rats exposed to nicotine during adolescence: relation to anxiety-like and depressive-like behaviorCraig J Slawecki
Department of Neuropharmacology, CVN 14, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
Neuropeptides 39:369-77. 2005..This study further examined the impact of adolescent nicotine exposure on anxiety-like and depressive-like behavior, as well as on levels of corticotropin-releasing factor (CRF) and neuropeptide Y (NPY) in this model... - Antagonism of neuropeptide YY1 receptors does not inhibit ethanol's effects on cortical EEG and ERPs in Wistar ratsCraig J Slawecki
The Scripps Research Institute, Department of Neuropharmacology, CFN 14, 10550 North Torrey Pines Road, La Jolla, California 92037, USA
J Stud Alcohol 66:559-66. 2005..In the present study, the NPY Y1 receptor antagonist BIBP3226 was administered alone or in combination with a moderate dose of ethanol to determine whether it interacted with the neurobehavioral effects of ethanol... - Enhanced prepulse inhibition following adolescent ethanol exposure in Sprague-Dawley ratsCraig J Slawecki
Scripps Research Institute, Department of Neuropharmacology, La Jolla, California 92037, USA
Alcohol Clin Exp Res 29:1829-36. 2005..Six days after the cessation of ethanol vapor exposure, the ASR and PPI were assessed... - Neurobehavioral profiles during the acute phase of ethanol withdrawal in adolescent and adult Sprague-Dawley ratsCraig J Slawecki
The Scripps Research Institute, Molecular and Integrative Neuroscience Department, La Jolla, CA 92037, USA
Behav Brain Res 170:41-51. 2006..Adolescent and adult rats show differential sensitivity to many of the effects of ethanol... - Neurokinin type-3 receptor stimulation impairs ethanol-associated appetitive behavior in Wistar ratsCraig J Slawecki
The Scripps Research Institute, Department of Neuropharmacology, La Jolla, CA 92037, USA
Alcohol Clin Exp Res 27:1962-70. 2003..In a follow-up study, senktide's effects on ethanol self-administration after intracerebroventricular (ICV) infusion were examined... - Increased anxiety-like behavior in adult rats exposed to nicotine as adolescentsCraig J Slawecki
Department of Neuropharmacology, CVN 14, Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
Pharmacol Biochem Behav 75:355-61. 2003..The purpose of this study was to further define the behavioral effects of nicotine exposure during adolescence... - Periadolescent alcohol exposure has lasting effects on adult neurophysiological function in ratsC J Slawecki
Department of Neuropharmacology, The Scripps Research Institute, La Jolla, CA 92037, USA
Brain Res Dev Brain Res 128:63-72. 2001..In addition, these data indicate that, in the absence of overt behavioral differences, there are long-lasting changes in the functional brain activity of adult rats briefly exposed to high levels of EtOH during the periadolescent period... - Effects of allopregnanolone on the EEG of alcohol-preferring and alcohol-nonpreferring ratsC J Slawecki
Department of Neuropharmacology, Scripps Research Institute, La Jolla, California 92037, USA
Alcohol Clin Exp Res 24:1369-75. 2000..The neuroactive steroid allopregnanolone is also a positive modulator of GABA-A receptors; therefore, we hypothesized that P and NP rats would respond differently to intraperitoneally administered allopregnanolone... - Neurophysiological findings and drinking levels in high-alcohol-drinking (HAD) and low-alcohol-drinking (LAD) ratsC J Slawecki
The Scripps Research Institute, Department of Neuropharmacoloy, La Jolla, California 92037, USA
Alcohol Clin Exp Res 24:1492-9. 2000.... - Differences in neurophysiological indices of associative learning in alcohol-preferring and nonpreferring ratsC J Slawecki
The Scripps Research Institute, Department of Neuropharmacology, La Jolla, California, USA
Alcohol Clin Exp Res 23:828-34. 1999..They also suggest more enhanced associative learning in P rats than in NP rats. This enhanced learning could be an innate trait of P rats or the result of altered learning due to differences in anxiety between P and NP rats... - Effects of adolescent ethanol exposure on ethanol consumption in adult ratsCraig J Slawecki
The Scripps Research Institute, Department of Neuropharmacology, CVN 14, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
Alcohol 26:23-30. 2002..Overall, these findings indicate that forced exposure to ethanol vapor during adolescence does not seem to be sufficient to alter initiation or maintenance of limited-access ethanol self-administration... - Comparison of the neurophysiological effects of allopregnanolone and ethanol in ratsC J Slawecki
Scripps Research Institute, Department of Neuropharmacology, La Jolla, CA 92037, USA
Psychopharmacology (Berl) 149:351-9. 2000..Although ethanol and allopregnanolone have similar behavioral effects, their macro-electrophysiological profiles have not been directly compared... - Altered EEG responses to ethanol in adult rats exposed to ethanol during adolescenceCraig J Slawecki
Scripps Research Institute, Department of Neuropharmacology, La Jolla, California 92037, USA
Alcohol Clin Exp Res 26:246-54. 2002..This study was designed to assess long-term changes in EEG activity after EtOH challenge in adult rats exposed to EtOH during adolescence... - Lasting effects of adolescent nicotine exposure on the electroencephalogram, event related potentials, and locomotor activity in the ratCraig J Slawecki
The Scripps Research Institute, Department of Neuropharmacology, CVN 14, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
Brain Res Dev Brain Res 138:15-25. 2002..These changes may be indicative of a lasting 'nicotine abstinence syndrome' characterized by increased arousal, anxiety, or emotionality... - EEG and ERP profiles in the high alcohol preferring (HAP) and low alcohol preferring (LAP) mice: relationship to ethanol preferenceCraig J Slawecki
Department of Neuropharmacology, The Scripps Research Institute, CVN 14, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
Brain Res 961:243-54. 2003..Decreased P3 latency in LAPs compared to HAPs and HS/Ibgs mice may be a 'protective factor'... - The effects of corticotropin-releasing factor on the cortical EEG are reduced following adolescent nicotine exposureCraig J Slawecki
Department of Neuropharmacology, The Scripps Research Institute, La Jolla, CA 92037, USA
Neuropeptides 37:66-73. 2003..Given the role of CRF systems in behavioral responses to stress and anxiety, these data suggest that adolescent nicotine exposure may produce long-term decreases in neurophysiological responses to stress... - Effects of neuropeptide Y on appetitive and consummatory behaviors associated with alcohol drinking in wistar rats with a history of ethanol exposureAnnika Thorsell
The Scripps Research Institute, Department of Neuropharmacology, La Jolla, California 92037, USA
Alcohol Clin Exp Res 29:584-90. 2005..Furthermore, NPY has a greater impact on the consummatory factors mediating ethanol intake than appetitive factors mediating ethanol seeking... - Effects of neuropeptide Y and corticotropin-releasing factor on ethanol intake in Wistar rats: interaction with chronic ethanol exposureAnnika Thorsell
The Scripps Research Institute, Department of Neuropharmacology, Mail Drop CVN-14, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
Behav Brain Res 161:133-40. 2005..Furthermore, the results presented here suggest that a balance between the stress-related peptides NPY and CRF may be involved in the regulation of ethanol intake... - The effects of social isolation on neuropeptide Y levels, exploratory and anxiety-related behaviors in ratsAnnika Thorsell
The Scripps Research Institute, Department of Neuropharmacology (CVN-14, 10550 N. Torrey Pines Rd, La Jolla, CA 92037, USA
Pharmacol Biochem Behav 83:28-34. 2006.... - Two-choice reaction time performance in Sprague-Dawley rats exposed to alcohol during adolescence or adulthoodCraig J Slawecki
Molecular and Integrative Neuroscience Department, The Scripps Research Institute, La Jolla, California 92037, USA
Behav Pharmacol 17:605-14. 2006.... - Effect of social isolation on ethanol consumption and substance P/neurokinin expression in Wistar ratsAnnika Thorsell
The Scripps Research Institute, Department of Neuropharmacology (CVN-14, 10550 N. Torrey Pines Road, La Jolla, CA 92037, USA
Alcohol 36:91-7. 2005..These data indicate that endogenous SP and neurokinin levels are reduced by isolation housing, but this was not associated with alterations in drinking levels using a two-bottle choice procedure... - Increased alcohol drinking in isolate-housed alcohol-preferring ratsCindy L Ehlers
Molecular and Integrative Neurosciences Department, The Scripps Research Institute, La Jolla, CA 92037, USA
Behav Neurosci 121:111-9. 2007..Selective enhancement of limited access ethanol drinking in P rats may represent a model whereby genetic liability to excessive drinking is enhanced by specific environmental exposures... - Neuropeptide Y administration into the amygdala does not affect ethanol consumptionSimon N Katner
The Scripps Research Institute, Department of Neuropharmacology, CVN 14, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
Alcohol 28:29-38. 2002..Overall, these findings support the suggestion that NPY administration into the central nucleus of the amygdala does not alter consumption of 10 E, 2S, or food, nor the cortical electroencephalographic or locomotor activity... - Event-related potential responses to alcohol-related stimuli in African-American young adults: relation to family history of alcoholism and drug usageCindy L Ehlers
Department of Neuropharmacology, The Scripps Research Institute, La Jolla, CA 92037, USA
Alcohol Alcohol 38:332-8. 2003..Taken together these studies further suggest that ERPs can provide specific information on alcoholism risk as well as use of other misused drugs...
Research Grants
- Neurobehavioral Consequences of Adolescent AlcoholCRAIG SLAWECKI; Fiscal Year: 2005..AIM 3: To investigate the neurochemical substrates underlying the lasting neurobehavioral consequences of adolescent ethanol exposure, with a focus on NMDA systems ..