Regine Sitruk-Ware

Summary

Affiliation: The Rockefeller University
Country: USA

Publications

  1. ncbi request reprint Pharmacological profile of progestins
    Regine Sitruk Ware
    Rockefeller University and Population Council, New York, NY, USA
    Maturitas 61:151-7. 2008
  2. pmc Contraception technology: past, present and future
    Regine Sitruk-Ware
    Population Council, New York, NY 10065, USA
    Contraception 87:319-30. 2013
  3. doi request reprint Characteristics and metabolic effects of estrogen and progestins contained in oral contraceptive pills
    Regine Sitruk-Ware
    Population Council and Rockefeller University, New York, NY 10065, USA
    Best Pract Res Clin Endocrinol Metab 27:13-24. 2013
  4. pmc Comparative actions of progesterone, medroxyprogesterone acetate, drospirenone and nestorone on breast cancer cell migration and invasion
    Xiao Dong Fu
    Molecular and Cellular Gynecological Endocrinology Laboratory MCGEL, Department of Reproductive Medicine and Child Development, University of Pisa, Pisa 56100, Italy
    BMC Cancer 8:166. 2008
  5. ncbi request reprint Contraception: an international perspective
    Regine Sitruk-Ware
    Population Council, New York, NY 10021, USA
    Contraception 73:215-22. 2006
  6. ncbi request reprint Mifepristone and misoprostol sequential regimen side effects, complications and safety
    Regine Sitruk-Ware
    Center for Biomedical Research, Population Council, Rockefeller University, New York, NY 10021, USA
    Contraception 74:48-55. 2006
  7. ncbi request reprint Routes of delivery for progesterone and progestins
    Regine Sitruk-Ware
    Rockefeller University and Population Council, New York, NY, USA
    Maturitas 57:77-80. 2007
  8. ncbi request reprint Effects of oral and transvaginal ethinyl estradiol on hemostatic factors and hepatic proteins in a randomized, crossover study
    Regine Sitruk-Ware
    Center for Biomedical Research, Population Council, New York, NY 10021, USA
    J Clin Endocrinol Metab 92:2074-9. 2007
  9. ncbi request reprint Comparison of the impact of vaginal and oral administration of combined hormonal contraceptives on hepatic proteins sensitive to estrogen
    Regine L Sitruk-Ware
    Center for Biomedical Research, Population Council, New York, NY 10021, USA
    Contraception 75:430-7. 2007
  10. pmc Pharmacokinetic study to compare the absorption and tolerability of two doses of levonorgestrel following single vaginal administration of levonorgestrel in Carraguard gel: a new formulation for "dual protection" contraception
    Regine Sitruk-Ware
    Population Council, Center for Biomedical Research, New York, NY 10021, USA
    Contraception 75:454-60. 2007

Research Grants

  1. Cooporative Contraceptive Research Center
    Regine Sitruk Ware; Fiscal Year: 2007
  2. Evaluation of a progesterone vaginal ring as a new contraceptive option in India
    REGINE SITRUK contact WARE; Fiscal Year: 2010

Collaborators

Detail Information

Publications46

  1. ncbi request reprint Pharmacological profile of progestins
    Regine Sitruk Ware
    Rockefeller University and Population Council, New York, NY, USA
    Maturitas 61:151-7. 2008
    ..The progestins available for therapy exhibit profound differences according to their structure or metabolites and it is inappropriate to consider the various effects of the old and new molecules as class-effects...
  2. pmc Contraception technology: past, present and future
    Regine Sitruk-Ware
    Population Council, New York, NY 10065, USA
    Contraception 87:319-30. 2013
    ..It is hoped that the introduction of new methods with additional health benefits would help women and couples with unmet needs to obtain access to a wider range of contraceptives with improved acceptability...
  3. doi request reprint Characteristics and metabolic effects of estrogen and progestins contained in oral contraceptive pills
    Regine Sitruk-Ware
    Population Council and Rockefeller University, New York, NY 10065, USA
    Best Pract Res Clin Endocrinol Metab 27:13-24. 2013
    ..Large surveillance studies are warranted to confirm this hypothesis...
  4. pmc Comparative actions of progesterone, medroxyprogesterone acetate, drospirenone and nestorone on breast cancer cell migration and invasion
    Xiao Dong Fu
    Molecular and Cellular Gynecological Endocrinology Laboratory MCGEL, Department of Reproductive Medicine and Child Development, University of Pisa, Pisa 56100, Italy
    BMC Cancer 8:166. 2008
    ..Cell migration and invasion are central for these processes, and require dynamic cytoskeletal and cell membrane rearrangements for cell motility to be enacted...
  5. ncbi request reprint Contraception: an international perspective
    Regine Sitruk-Ware
    Population Council, New York, NY 10021, USA
    Contraception 73:215-22. 2006
    ..In the future, contraceptives may be combined with other medicinal agents to provide dual protection against both pregnancy and other preventable conditions, such as sexually transmitted infections...
  6. ncbi request reprint Mifepristone and misoprostol sequential regimen side effects, complications and safety
    Regine Sitruk-Ware
    Center for Biomedical Research, Population Council, Rockefeller University, New York, NY 10021, USA
    Contraception 74:48-55. 2006
    ..Special emphasis is given to the rare but relevant safety issues, that is, heavy uterine bleeding, pelvic infections and continuing pregnancies. The rationale for warnings and contraindications for use of the product are also explained...
  7. ncbi request reprint Routes of delivery for progesterone and progestins
    Regine Sitruk-Ware
    Rockefeller University and Population Council, New York, NY, USA
    Maturitas 57:77-80. 2007
    ..The assumption that these new delivery systems should lead to an improved risk/benefit ratio in HT will need to be demonstrated in larger randomized controlled studies...
  8. ncbi request reprint Effects of oral and transvaginal ethinyl estradiol on hemostatic factors and hepatic proteins in a randomized, crossover study
    Regine Sitruk-Ware
    Center for Biomedical Research, Population Council, New York, NY 10021, USA
    J Clin Endocrinol Metab 92:2074-9. 2007
    ..Evaluation of the impact of delivery route on these changes is difficult due to an interaction between EE and the progestin component...
  9. ncbi request reprint Comparison of the impact of vaginal and oral administration of combined hormonal contraceptives on hepatic proteins sensitive to estrogen
    Regine L Sitruk-Ware
    Center for Biomedical Research, Population Council, New York, NY 10021, USA
    Contraception 75:430-7. 2007
    ..We also investigated the effect of delivery route, which is known to modify the hepatic effects of estradiol, but has not been widely studied with EE...
  10. pmc Pharmacokinetic study to compare the absorption and tolerability of two doses of levonorgestrel following single vaginal administration of levonorgestrel in Carraguard gel: a new formulation for "dual protection" contraception
    Regine Sitruk-Ware
    Population Council, Center for Biomedical Research, New York, NY 10021, USA
    Contraception 75:454-60. 2007
    ....
  11. doi request reprint The use of newer progestins for contraception
    Regine Sitruk-Ware
    Population Council and Rockefeller University, New York, NY 10065, USA
    Contraception 82:410-7. 2010
    ..Risks and benefits of the new progestins depend upon the type of molecular structure, the type of estrogen associated in a combination and the route of administration...
  12. doi request reprint Metabolic effects of contraceptive steroids
    Regine Sitruk-Ware
    Center for Biomedical Research, Population Council, Rockefeller University, New York, NY, USA
    Rev Endocr Metab Disord 12:63-75. 2011
    ..So far, the contraindications and warnings for use of current COCs also apply to the estradiol-based COCs...
  13. ncbi request reprint Vaginal delivery of contraceptives
    Regine Sitruk-Ware
    Center for Biomedical Research, Population Council, New York, NY 10021, USA
    Expert Opin Drug Deliv 2:729-36. 2005
    ..This review will address the specifics of the vaginal route for delivering contraceptive steroids and describe the various systems available or under evaluation...
  14. ncbi request reprint Pharmacological properties of mifepristone: toxicology and safety in animal and human studies
    Regine Sitruk-Ware
    Center for Biomedical Research, Population Council Regine Sitruk Ware Center for Biomedical Research, 1230 York Avenue, 6th Floor, New York, NY 10021, USA
    Contraception 68:409-20. 2003
    ..Although political and philosophical obstacles have delayed research, the use of mifepristone for other potential indications in gynecology or oncology should be investigated...
  15. ncbi request reprint Progestins and cardiovascular risk markers
    R Sitruk-Ware
    Department of Endocrinology, St Antoine Hospital, Paris, France
    Steroids 65:651-8. 2000
    ..Unfortunately, most of these large trials have selected the same HRT regimen for their study design. Further studies with other treatment regimens are thus needed and should consider the various steroids used in different countries...
  16. ncbi request reprint Pharmacological profile of progestins
    Regine Sitruk-Ware
    Rockefeller University and Population Council, New York, NY, USA
    Maturitas 47:277-83. 2004
    ..The progestins available for therapy exhibit profound differences according to their structure or metabolites and it is inappropriate to consider the various effects of the old and new molecules as class-effects...
  17. ncbi request reprint Progestogens in hormonal replacement therapy: new molecules, risks, and benefits
    Regine Sitruk-Ware
    Center for Biomedical Research, Population Council, 1230 York Ave, New York, NY 10021, USA
    Menopause 9:6-15. 2002
    ..Complying with the classic contraindications of HRT and selecting molecules devoid of estrogenic, androgenic, or glucocorticoid effect should allow a larger use of the progestins without any major drawback...
  18. ncbi request reprint Hormonal replacement therapy
    Regine Sitruk-Ware
    Rockefeller University and Population Council, New York, NY, USA
    Rev Endocr Metab Disord 3:243-56. 2002
  19. ncbi request reprint New progestogens: a review of their effects in perimenopausal and postmenopausal women
    Regine Sitruk-Ware
    Rockefeller University and Population Council, New York, New York, USA
    Drugs Aging 21:865-83. 2004
    ....
  20. ncbi request reprint Exogenous progestagens and the human breast
    Regine Sitruk-Ware
    Population Council, Rockefeller University, New York, NY 10021, USA
    Maturitas 49:58-66. 2004
    ....
  21. doi request reprint Parenteral administration of progestins for hormonal replacement therapy
    Anita Nath
    Tietze fellow from the Population Council, New York, NY 10065, USA
    Eur J Contracept Reprod Health Care 14:88-96. 2009
    ..Although parenteral administration of progesterone or low-dose progestins should in theory be associated with fewer side-effects than oral therapy, the long-term safety of the newer systems warrants further evaluation...
  22. ncbi request reprint Nestorone: clinical applications for contraception and HRT
    Regine Sitruk-Ware
    Center for Biomedical Research, Population Council, Rockefeller University, 1230 York Avenue, Weiss Bldg, 6th Floor, New York, NY 10021, USA
    Steroids 68:907-13. 2003
    ..Nestorone has also been used effectively in a single implant for contraception in breastfeeding women and shows promise for use in transdermal systems as a contraceptive or for HT when combined with estrogen...
  23. ncbi request reprint The levonorgestrel intrauterine system for use in peri- and postmenopausal women
    Regine Sitruk-Ware
    Center for Biomedical Research Population Council, Rockefeller University, New York, NY 10021, USA
    Contraception 75:S155-60. 2007
    ..In addition, the insertion of the system needs a skilled health provider and may be difficult or painful when the uterus is small or atrophic. The development of smaller devices is warranted for these specific situations...
  24. ncbi request reprint Preclinical and clinical properties of trimegestone: a potent and selective progestin
    Regine Sitruk-Ware
    Rockefeller University and Population Council, New York 10021, USA
    Gynecol Endocrinol 23:310-9. 2007
    ..Therefore, it may be concluded that TMG provides a clinically proven option in hormone therapy for both clinicians and patients...
  25. ncbi request reprint New progestagens for contraceptive use
    Regine Sitruk-Ware
    Rockefeller University and Population Council, New York, NY, USA
    Hum Reprod Update 12:169-78. 2006
    ..Given their pharmacological properties, it is likely that the new progestins may have neutral effects on metabolic or vascular risks. However, this hypothesis must be confirmed in large clinical trials...
  26. ncbi request reprint Cyclical mastalgia and breast cancer risk: results of a French cohort study
    Genevieve Plu-Bureau
    Department of Reproductive Endocrinology, Hospital Necker, Paris, France
    Cancer Epidemiol Biomarkers Prev 15:1229-31. 2006
    ..It might be a confounding factor when assessing the effects of hormonal treatments on breast cancer risk such as hormonal replacement therapy or oral contraceptives...
  27. doi request reprint Single-dose pharmacokinetics of Nestorone, a potential female-contraceptive
    Pramod Vishwanath Prasad
    Center for Biomedical Research, The Population Council, The Rockefeller University, 1230 York Avenue, New York, NY 10065, USA
    Steroids 75:252-64. 2010
    ..The distribution, metabolism, and excretion profiles of (3)H Nestorone obtained in this study provide a fairly good insight about its fate in women...
  28. ncbi request reprint Delivery options for contraceptives
    Regine Sitruk-Ware
    Center for Biomedical Research, Rockefeller University, 1230 York Avenue, New York, NY 10021, USA
    Drug Discov Today 10:977-85. 2005
    ..A contraceptive method providing dual medical benefits might increase motivation for consistent use, thus reducing contraceptive failures and unwanted pregnancies...
  29. ncbi request reprint The levonorgestrel intrauterine system: long-term contraception and therapeutic effects
    Regine Sitruk-Ware
    Population Council, 1230 York Avenue, New York 10021, USA
    Womens Health (Lond Engl) 1:171-82. 2005
    ..It is one of the most effective methods of contraception and is approved in more than 100 countries for 5 years of use...
  30. doi request reprint Progesterone vaginal ring for contraceptive use during lactation
    Anita Nath
    Population Council, New York, NY 10065, USA
    Contraception 82:428-34. 2010
    ..Further evaluation of the PVR acceptability in different populations where breastfeeding is popular and highly recommended for the infant's benefit is warranted...
  31. ncbi request reprint Progestins in hormonal therapy (HT) today, tomorrow and the next day: a roundtable discussion
    Regine Sitruk-Ware
    Center for Biomedical Research, Population Council, Rockefeller University, 1230 York Ave, Weiss Bldg, 6th Floor, New York, NY 10021, USA
    Steroids 68:973-9. 2003
  32. doi request reprint Postpartum unintended pregnancy and contraception practice among rural-to-urban migrant women in Shanghai
    Yong Mei Huang
    Center for Biomedical Research, Population Council, Rockefeller University, New York, NY 10065, USA
    Contraception 86:731-8. 2012
    ..Rural-to-urban migrant women in Shanghai have poor reproductive health; the incidence of postpartum unintended pregnancy and contraceptive practices has not been adequately studied in this population...
  33. doi request reprint Distribution, metabolism and excretion of a synthetic androgen 7alpha-methyl-19-nortestosterone, a potential male-contraceptive
    Pramod Vishwanath Prasad
    Center for Biomedical Research, The Population Council, The Rockefeller University, 1230 York Avenue, New York, NY 10065, USA
    Steroids 74:121-31. 2009
    ....
  34. ncbi request reprint New delivery systems in contraception: vaginal rings
    Elof D B Johansson
    Center for Biomedical Research, Population Council, New York, NY 10021, USA
    Am J Obstet Gynecol 190:S54-9. 2004
    ..Combination rings are associated with very low pregnancy rates and side effects consistent with those of oral contraceptives...
  35. ncbi request reprint Estrogen and progestogens--different routes of administration
    Regine Sitruk-Ware
    Climacteric 8:1-2. 2005
  36. ncbi request reprint Effects of levonorgestrel-releasing IUS and progesterone receptor modulator PRM CDB-2914 on uterine leiomyomas
    Takeshi Maruo
    Department of Obstetrics and Gynecology, Kobe University Graduate School of Medicine, Kobe, 650 0017, Japan
    Contraception 75:S99-103. 2007
    ..The cell type-specific action of CDB2914 on leiomyoma cells, without affecting the surrounding normal myometrial cells, is meaningful for understanding the usefulness of CDB2914 in the medical treatment of uterine myomas...
  37. ncbi request reprint Mifepristone does not induce cervical softening in non-pregnant women
    Avraham Ben-Chetrit
    Women s Health Center Ramat Eshkol, Department of Obstetrics and Gynecology, and Institute of Hormone Research, Shaare Zedek Medical Center, Jerusalem, Israel
    Hum Reprod 19:2372-6. 2004
    ..We used the progesterone antagonist mifepristone as a cervical ripening agent and evaluated its effect prior to office hysteroscopy...
  38. pmc Effect of a single vaginal administration of levonorgestrel in Carraguard gel on the ovulatory process: a potential candidate for "dual protection" emergency contraception
    Vivian Brache
    PROFAMILIA, Biomedical Research Department, P O Box 1053, Santo Domingo 10401, Dominican Republic
    Contraception 76:111-6. 2007
    ..75 mg of levonorgestrel (CARRA/LNG gel) administered in a single dose at different stages of follicle development over subsequent follicle rupture and hormonal levels...
  39. ncbi request reprint An initial pharmacokinetic study with a Metered Dose Transdermal Systemfor delivery of the progestogen Nestorone as a possible future contraceptive
    Ian S Fraser
    Department of Obstetrics and Gynaecology, University of Sydney, NSW 2006, Australia
    Contraception 76:432-8. 2007
    ..This study aimed to test metered spray delivery of a precise dosage of Nestorone (NES) progestogen as a possible transdermal progestogen-only contraceptive...
  40. ncbi request reprint Long-term administration of mifepristone (RU486): clinical tolerance during extended treatment of meningioma
    Steven M Grunberg
    Division of Hematology Oncology, University of Vermont College of Medicine, Burlington, Vermont, USA
    Cancer Invest 24:727-33. 2006
    ..Meningioma is a benign central nervous system tumor that is often progesterone-but not estrogen-receptor positive, making long-term antiprogestational therapy a logical treatment strategy...
  41. ncbi request reprint Bone and muscle protective potential of the prostate-sparing synthetic androgen 7alpha-methyl-19-nortestosterone: evidence from the aged orchidectomized male rat model
    Katrien Venken
    Laboratory for Experimental Medicine and Endocrinology, Onderwijs en Navorsing, Campus Gasthuisberg, Leuven, Belgium
    Bone 36:663-70. 2005
    ..Our findings support the need for human studies to explore the potential of MENT as an option for androgen replacement in aging men...
  42. doi request reprint Progesterone receptor modulator CDB-2914 induces extracellular matrix metalloproteinase inducer in cultured human uterine leiomyoma cells
    Qin Xu
    Department of Obstetrics and Gynecology, Kobe University Graduate School of Medicine, 7 5 1 Kusunoki cho, Chuo Ku, Kobe, Hyogo Prefecture 650 0017, Japan
    Mol Hum Reprod 14:181-91. 2008
    ..These results suggest that CDB-2914 modulates the expression of EMMPRIN, MMPs, TIMPs and collagens in cultured leiomyoma cells without comparable effects on myometrial cells...
  43. ncbi request reprint Management of patients receiving long-term treatment with mifepristone
    Irving M Spitz
    Institute of Hormone Research, Jerusalem, Israel
    Fertil Steril 84:1719-26. 2005
    ..To determine clinical side effects and biochemical and hematological abnormalities in patients with nonresectable meningioma on long-term mifepristone (RU 486) therapy...
  44. ncbi request reprint Progesterone receptor modulator CDB-2914 down-regulates proliferative cell nuclear antigen and Bcl-2 protein expression and up-regulates caspase-3 and poly(adenosine 5'-diphosphate-ribose) polymerase expression in cultured human uterine leiomyoma cells
    Qin Xu
    Department of Obstetrics and Gynecology, Kobe University Graduate School of Medicine, Chuo Ku, Kobe 650 0017, Japan
    J Clin Endocrinol Metab 90:953-61. 2005
    ....
  45. doi request reprint Determinants of the rate and extent of spermatogenic suppression during hormonal male contraception: an integrated analysis
    Peter Y Liu
    Department of Andrology, ANZAC Research Institute, University of Sydney and Concord Hospital, Concord, New South Wales 2139, Australia
    J Clin Endocrinol Metab 93:1774-83. 2008
    ..Male hormonal contraceptive methods require effective suppression of sperm output...
  46. ncbi request reprint Progesterone receptor modulator CDB-2914 down-regulates vascular endothelial growth factor, adrenomedullin and their receptors and modulates progesterone receptor content in cultured human uterine leiomyoma cells
    Qin Xu
    Department of Obstetrics and Gynecology, Kobe University Graduate School of Medicine, Kobe, Japan
    Hum Reprod 21:2408-16. 2006
    ....

Research Grants3

  1. Cooporative Contraceptive Research Center
    Regine Sitruk Ware; Fiscal Year: 2007
    ..The overall goal is to explore the prospect of the Adjudin-FSH mutant conjugate's candidacy as a male contraceptive, by targeting germ cell adhesion. Alternative delivery routes will be studied. ..
  2. Evaluation of a progesterone vaginal ring as a new contraceptive option in India
    REGINE SITRUK contact WARE; Fiscal Year: 2010
    ....