Affiliation: The Rockefeller University
Sitruk Ware R, Nath A. The use of newer progestins for contraception. Contraception. 2010;82:410-7 pubmed publisher
..Risks and benefits of the new progestins depend upon the type of molecular structure, the type of estrogen associated in a combination and the route of administration. ..
Sitruk Ware R, Nath A, Mishell D. Contraception technology: past, present and future. Contraception. 2013;87:319-30 pubmed publisher
..It is hoped that the introduction of new methods with additional health benefits would help women and couples with unmet needs to obtain access to a wider range of contraceptives with improved acceptability. ..
Huang Y, Jensen J, Brache V, Cochon L, Williams A, Miranda M, et al
. A randomized study on pharmacodynamic effects of vaginal rings delivering the progesterone receptor modulator ulipristal acetate: research for a novel estrogen-free, method of contraception. Contraception. 2014;90:565-74 pubmed publisher
..The prevention of occasional excessive withdrawal bleeding, either by a progestin or by using higher UPA levels to increase follicle suppression may permit prolonged treatment. ..
Sitruk Ware R. Hormonal contraception and thrombosis. Fertil Steril. 2016;106:1289-1294 pubmed publisher
..Careful consideration of individual risk factors should be given before prescribing to avoid cumulative risks and minimize the occurrence of unwanted events. ..
Sitruk Ware R. Mifepristone and misoprostol sequential regimen side effects, complications and safety. Contraception. 2006;74:48-55 pubmed
..Special emphasis is given to the rare but relevant safety issues, that is, heavy uterine bleeding, pelvic infections and continuing pregnancies. The rationale for warnings and contraindications for use of the product are also explained. ..
Sitruk Ware R, Ménard J, Rad M, Burggraaf J, de Kam M, Tokay B, et al
. Comparison of the impact of vaginal and oral administration of combined hormonal contraceptives on hepatic proteins sensitive to estrogen. Contraception. 2007;75:430-7 pubmed
..No treatment difference was observed for angiotensinogen, which is sensitive only to estrogen. The observed treatment differences were therefore most likely due to the difference in androgenicity between NES and LNG. ..
Fu X, Giretti M, Goglia L, Flamini M, Sanchez A, Baldacci C, et al
. Comparative actions of progesterone, medroxyprogesterone acetate, drospirenone and nestorone on breast cancer cell migration and invasion. BMC Cancer. 2008;8:166 pubmed publisher
..These findings support the concept that each progestin acts differently on breast cancer cells, which may have relevant clinical implications. ..