Ann Marie Simeone

Summary

Affiliation: The University of Texas
Country: USA

Publications

  1. pmc TIMP-2 mediates the anti-invasive effects of the nitric oxide-releasing prodrug JS-K in breast cancer cells
    Ann Marie Simeone
    Department of Experimental Therapeutics, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
    Breast Cancer Res 10:R44. 2008
  2. ncbi N-(4-Hydroxyphenyl)retinamide is more potent than other phenylretinamides in inhibiting the growth of BRCA1-mutated breast cancer cells
    Ann Marie Simeone
    Department of Experimental Therapeutics, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
    Carcinogenesis 26:1000-7. 2005
  3. ncbi N-(4-Hydroxyphenyl)retinamide and nitric oxide pro-drugs exhibit apoptotic and anti-invasive effects against bone metastatic breast cancer cells
    Ann Marie Simeone
    Department of Experimental Therapeutics, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Carcinogenesis 27:568-77. 2006
  4. ncbi A novel mechanism by which N-(4-hydroxyphenyl)retinamide inhibits breast cancer cell growth: the production of nitric oxide
    Ann Marie Simeone
    Department of Bioimmunotherapy, Sections of Immunobiology and Drug Carriers, University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
    Mol Cancer Ther 1:1009-17. 2002
  5. pmc Differential regulation of the aggressive phenotype of inflammatory breast cancer cells by prostanoid receptors EP3 and EP4
    Fredika M Robertson
    Department of Experimental Therapeutics, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Cancer 116:2806-14. 2010
  6. ncbi Cyclooxygenase-2 is essential for HER2/neu to suppress N- (4-hydroxyphenyl)retinamide apoptotic effects in breast cancer cells
    Ann Marie Simeone
    Department of Bioimmunotherapy, Section of Immunobiology and Drug Carriers, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Cancer Res 64:1224-8. 2004
  7. doi JS-K, a nitric oxide-releasing prodrug, induces breast cancer cell death while sparing normal mammary epithelial cells
    Vanity McMurtry
    Department of Experimental Therapeutics, University of Texas MD Anderson Cancer Center, Houston, TX, USA
    Int J Oncol 38:963-71. 2011
  8. ncbi HER2/neu reduces the apoptotic effects of N-(4-hydroxyphenyl)retinamide (4-HPR) in breast cancer cells by decreasing nitric oxide production
    Ann Marie Simeone
    Department of Bioimmunotherapy, Section of Immunobiology and Drug Carriers, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
    Oncogene 22:6739-47. 2003
  9. ncbi Molecular and pharmacological blockade of the EP4 receptor selectively inhibits both proliferation and invasion of human inflammatory breast cancer cells
    Fredika M Robertson
    Department of Experimental Therapeutics, 1515 Holcombe Blvd, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    J Exp Ther Oncol 7:299-312. 2008
  10. pmc Programmed cell death 4 inhibits breast cancer cell invasion by increasing tissue inhibitor of metalloproteinases-2 expression
    Rene Nieves-Alicea
    Department of Experimental Therapeutics, The University of Texas MD Anderson Cancer Center, Unit 422, Houston, TX 77030, USA
    Breast Cancer Res Treat 114:203-9. 2009

Collaborators

Detail Information

Publications14

  1. pmc TIMP-2 mediates the anti-invasive effects of the nitric oxide-releasing prodrug JS-K in breast cancer cells
    Ann Marie Simeone
    Department of Experimental Therapeutics, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
    Breast Cancer Res 10:R44. 2008
    ..NO prodrugs generate large amounts of NO upon metabolism by appropriate intracellular enzymes, and therefore could have potential in the prevention and therapy of metastatic breast cancer...
  2. ncbi N-(4-Hydroxyphenyl)retinamide is more potent than other phenylretinamides in inhibiting the growth of BRCA1-mutated breast cancer cells
    Ann Marie Simeone
    Department of Experimental Therapeutics, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
    Carcinogenesis 26:1000-7. 2005
    ..These in vitro results suggest that 4-HPR may be an effective chemopreventive agent against breast tumors that exhibit BRCA1 mutations because of its ability to induce NO-mediated apoptosis in such tumors...
  3. ncbi N-(4-Hydroxyphenyl)retinamide and nitric oxide pro-drugs exhibit apoptotic and anti-invasive effects against bone metastatic breast cancer cells
    Ann Marie Simeone
    Department of Experimental Therapeutics, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Carcinogenesis 27:568-77. 2006
    ..These in vitro results suggest that 4-HPR and NO pro-drugs may be effective chemopreventive agents against bone metastatic breast cancer...
  4. ncbi A novel mechanism by which N-(4-hydroxyphenyl)retinamide inhibits breast cancer cell growth: the production of nitric oxide
    Ann Marie Simeone
    Department of Bioimmunotherapy, Sections of Immunobiology and Drug Carriers, University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
    Mol Cancer Ther 1:1009-17. 2002
    ..When combined with 4-HPR, IFN-gamma and TAM enhanced NOSII expression. Thus, we have identified a novel mechanism by which 4-HPR induces apoptosis in breast cancer cells, i.e., by increasing NOS expression to induce NO production...
  5. pmc Differential regulation of the aggressive phenotype of inflammatory breast cancer cells by prostanoid receptors EP3 and EP4
    Fredika M Robertson
    Department of Experimental Therapeutics, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Cancer 116:2806-14. 2010
    ....
  6. ncbi Cyclooxygenase-2 is essential for HER2/neu to suppress N- (4-hydroxyphenyl)retinamide apoptotic effects in breast cancer cells
    Ann Marie Simeone
    Department of Bioimmunotherapy, Section of Immunobiology and Drug Carriers, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Cancer Res 64:1224-8. 2004
    ..Combining 4-HPR with COX-2 inhibitors may be a novel chemopreventive strategy against HER2/neu-overexpressing breast tumors...
  7. doi JS-K, a nitric oxide-releasing prodrug, induces breast cancer cell death while sparing normal mammary epithelial cells
    Vanity McMurtry
    Department of Experimental Therapeutics, University of Texas MD Anderson Cancer Center, Houston, TX, USA
    Int J Oncol 38:963-71. 2011
    ..The selective anti-tumor activity of JS-K warrants its further investigation in breast tumors...
  8. ncbi HER2/neu reduces the apoptotic effects of N-(4-hydroxyphenyl)retinamide (4-HPR) in breast cancer cells by decreasing nitric oxide production
    Ann Marie Simeone
    Department of Bioimmunotherapy, Section of Immunobiology and Drug Carriers, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
    Oncogene 22:6739-47. 2003
    ....
  9. ncbi Molecular and pharmacological blockade of the EP4 receptor selectively inhibits both proliferation and invasion of human inflammatory breast cancer cells
    Fredika M Robertson
    Department of Experimental Therapeutics, 1515 Holcombe Blvd, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    J Exp Ther Oncol 7:299-312. 2008
    ..This is the first report using both a selective pharmacologic inhibitor and a molecular shRNA knockdown approach to demonstrate that EP4 is directly involved in regulation of proliferation and invasion of IBC cells...
  10. pmc Programmed cell death 4 inhibits breast cancer cell invasion by increasing tissue inhibitor of metalloproteinases-2 expression
    Rene Nieves-Alicea
    Department of Experimental Therapeutics, The University of Texas MD Anderson Cancer Center, Unit 422, Houston, TX 77030, USA
    Breast Cancer Res Treat 114:203-9. 2009
    ..Here we report the novel findings that suppression of PDCD4 expression is vital for the invasive activity of COX-2 mediated by PGE(2) and IL-8, and that PDCD4 increases TIMP-2 expression to inhibit breast cancer cell invasion...
  11. doi Leptin utilizes Jun N-terminal kinases to stimulate the invasion of MCF-7 breast cancer cells
    Vanity McMurtry
    Department of Experimental Therapeutics, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX, USA
    Clin Exp Metastasis 26:197-204. 2009
    ..Furthermore, inhibition of JNK suppressed leptin-mediated breast cancer cell invasion. Here we report the novel findings that leptin increased invasion of breast cancer cells by activating JNK, resulting in increased MMP-2 activity...
  12. ncbi Cyclooxygenase-2 uses the protein kinase C/ interleukin-8/urokinase-type plasminogen activator pathway to increase the invasiveness of breast cancer cells
    Ann Marie Simeone
    Department of Experimental Therapeutics, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Int J Oncol 30:785-92. 2007
    ..Herein we demonstrate for the first time a detailed mechanism by which COX-2 increases breast cancer invasion: the PKC/IL-8/uPA pathway...
  13. ncbi Cyclooxygenase-2 protein reduces tamoxifen and N-(4-hydroxyphenyl)retinamide inhibitory effects in breast cancer cells
    Ana M Tari
    Department of Experimental Therapeutics, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
    Lab Invest 85:1357-67. 2005
    ..Here we report the novel findings that COX-2 uses PGE2 to stimulate the activities of protein kinases A and C to induce selectively tamoxifen and 4-HPR resistance in ERalpha-positive breast cancer cells...
  14. ncbi Cyclosporin A enhances the apoptotic effects of N-(4-hydroxyphenyl)retinamide in breast cancer cells
    Soo Jeong Lim
    Section of Immunobiology and Drug Carriers, Department of Bioimmunotherapy, University of Texas M D Anderson Cancer Center, Houston 77030, USA
    Int J Cancer 101:243-7. 2002
    ..Thus, the 4HPR and cyclosporin A combination may potentially be a novel therapeutic modality against breast tumors...