GEORGE SIGGINS

Summary

Affiliation: The Scripps Research Institute
Country: USA

Publications

  1. ncbi request reprint The tipsy terminal: presynaptic effects of ethanol
    George Robert Siggins
    Department of Neuropharmacology and Alcohol Research Center, The Scripps Research Institute, CVN 12, 10550 N Torrey Pines Road, La Jolla, CA 92037, USA
    Pharmacol Ther 107:80-98. 2005
  2. ncbi request reprint Glutamatergic transmission in opiate and alcohol dependence
    George Robert Siggins
    Department of Neuropharmacology, Department of Molecular Biology, The Scripps Research Institute, 10550 Torrey Pines Road, La Jolla, California 92037, USA
    Ann N Y Acad Sci 1003:196-211. 2003
  3. ncbi request reprint Interaction of the hypocretins with neurotransmitters in the nucleus accumbens
    Gilles Martin
    Department of Neuropharmacology, The Scripps Research Institute, La Jolla, CA 92037, USA
    Regul Pept 104:111-7. 2002
  4. pmc Cellular and behavioral interactions of gabapentin with alcohol dependence
    Marisa Roberto
    Committee on the Neurobiology of Addictive Disorders, Pearson Center for Alcoholism and Addiction Research, The Scripps Research Institute, La Jolla, California 92037, USA
    J Neurosci 28:5762-71. 2008
  5. pmc Nociceptin/orphanin FQ presynaptically decreases GABAergic transmission and blocks the ethanol-induced increase of GABA release in central amygdala
    Marisa Roberto
    Molecular and Integrative Neurosciences Department, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 103:9715-20. 2006
  6. ncbi request reprint Chronic ethanol exposure and protracted abstinence alter NMDA receptors in central amygdala
    Marisa Roberto
    Department of Neuropharmacology, The Scripps Research Institute, La Jolla, CA 92037, USA
    Neuropsychopharmacology 31:988-96. 2006
  7. ncbi request reprint Chronic morphine treatment alters N-methyl-D-aspartate receptors in freshly isolated neurons from nucleus accumbens
    Gilles Martin
    Department of Neuropharmacology, The Scripps Research Institute, La Jolla, CA, USA
    J Pharmacol Exp Ther 311:265-73. 2004
  8. ncbi request reprint Acute and chronic ethanol alter glutamatergic transmission in rat central amygdala: an in vitro and in vivo analysis
    Marisa Roberto
    Department of Neuropharmacology, The Scripps Research Institute, La Jolla, California 92037, USA
    J Neurosci 24:1594-603. 2004
  9. ncbi request reprint The sleep-modulating peptide cortistatin augments the h-current in hippocampal neurons
    Paul Schweitzer
    Department of Neuropharmacology, The Scripps Research Institute, La Jolla, California 92037, USA
    J Neurosci 23:10884-91. 2003
  10. pmc Ethanol increases GABAergic transmission at both pre- and postsynaptic sites in rat central amygdala neurons
    Marisa Roberto
    Department of Neuropharmacology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 100:2053-8. 2003

Research Grants

Detail Information

Publications16

  1. ncbi request reprint The tipsy terminal: presynaptic effects of ethanol
    George Robert Siggins
    Department of Neuropharmacology and Alcohol Research Center, The Scripps Research Institute, CVN 12, 10550 N Torrey Pines Road, La Jolla, CA 92037, USA
    Pharmacol Ther 107:80-98. 2005
    ..Such studies could lead to the formulation of new treatment strategies for alcohol intoxication, alcohol abuse, and alcoholism...
  2. ncbi request reprint Glutamatergic transmission in opiate and alcohol dependence
    George Robert Siggins
    Department of Neuropharmacology, Department of Molecular Biology, The Scripps Research Institute, 10550 Torrey Pines Road, La Jolla, California 92037, USA
    Ann N Y Acad Sci 1003:196-211. 2003
    ..These combined findings suggest that changes in glutamatergic transmission in NAcc and CeA may underlie the neuroadaptions that lead to opiate and ethanol dependence...
  3. ncbi request reprint Interaction of the hypocretins with neurotransmitters in the nucleus accumbens
    Gilles Martin
    Department of Neuropharmacology, The Scripps Research Institute, La Jolla, CA 92037, USA
    Regul Pept 104:111-7. 2002
    ..Our results strongly suggest that the hypocretin peptides may be inhibitory peptides, probably via binding hcrt receptor 2...
  4. pmc Cellular and behavioral interactions of gabapentin with alcohol dependence
    Marisa Roberto
    Committee on the Neurobiology of Addictive Disorders, Pearson Center for Alcoholism and Addiction Research, The Scripps Research Institute, La Jolla, California 92037, USA
    J Neurosci 28:5762-71. 2008
    ....
  5. pmc Nociceptin/orphanin FQ presynaptically decreases GABAergic transmission and blocks the ethanol-induced increase of GABA release in central amygdala
    Marisa Roberto
    Molecular and Integrative Neurosciences Department, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 103:9715-20. 2006
    ..Our data suggest that nociceptin has a role in regulating the GABAergic system and opposing the effect elicited by ethanol. Thus, nociceptin may represent a therapeutic target for alleviating alcohol dependence...
  6. ncbi request reprint Chronic ethanol exposure and protracted abstinence alter NMDA receptors in central amygdala
    Marisa Roberto
    Department of Neuropharmacology, The Scripps Research Institute, La Jolla, CA 92037, USA
    Neuropsychopharmacology 31:988-96. 2006
    ..These data indicate that CET induces reversible neuroadaptations in synaptic function, gene expression, and protein composition of NMDAR at CeA synapses...
  7. ncbi request reprint Chronic morphine treatment alters N-methyl-D-aspartate receptors in freshly isolated neurons from nucleus accumbens
    Gilles Martin
    Department of Neuropharmacology, The Scripps Research Institute, La Jolla, CA, USA
    J Pharmacol Exp Ther 311:265-73. 2004
    ....
  8. ncbi request reprint Acute and chronic ethanol alter glutamatergic transmission in rat central amygdala: an in vitro and in vivo analysis
    Marisa Roberto
    Department of Neuropharmacology, The Scripps Research Institute, La Jolla, California 92037, USA
    J Neurosci 24:1594-603. 2004
    ....
  9. ncbi request reprint The sleep-modulating peptide cortistatin augments the h-current in hippocampal neurons
    Paul Schweitzer
    Department of Neuropharmacology, The Scripps Research Institute, La Jolla, California 92037, USA
    J Neurosci 23:10884-91. 2003
    ..Our results indicate that CST targets a specific conductance unaffected by SST to modulate cellular mechanisms implicated in sleep regulation...
  10. pmc Ethanol increases GABAergic transmission at both pre- and postsynaptic sites in rat central amygdala neurons
    Marisa Roberto
    Department of Neuropharmacology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 100:2053-8. 2003
    ..These findings add further support to the contention that the ethanol-GABA interaction in CeA plays an important role in the reinforcing effects of ethanol...
  11. ncbi request reprint Targeted disruption of RC3 reveals a calmodulin-based mechanism for regulating metaplasticity in the hippocampus
    Thomas Krucker
    Departments of Neuropharmacology and Molecular Biology, The Scripps Research Institute, La Jolla, California 92037, USA
    J Neurosci 22:5525-35. 2002
    ..We propose an mGluR-dependent CaM-based sliding threshold mechanism for metaplasticity that is governed by the phosphorylation states of RC3 and CaMKII...
  12. ncbi request reprint Potential neuroprotective effects of acamprosate
    George F Koob
    Department of Neuropharmacology, The Scripps Research Institute, La Jolla, California, USA
    Alcohol Clin Exp Res 26:586-92. 2002
    ..Siggins; (3) Acamprosate and glutamate during ethanol withdrawal, by Philippe De Witte; (4) Clinical evidence of protective CNS effects of acamprosate in alcohol-dependent individuals, by Barbara J. Mason...
  13. pmc Protein kinase C epsilon mediation of CRF- and ethanol-induced GABA release in central amygdala
    Michal Bajo
    Molecular and Integrative Neurosciences Department, Committee on Neurobiology of Addictive Disorders, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 105:8410-5. 2008
    ..These results identify a PKCepsilon signaling pathway in the CeA that is activated by CRF(1) receptor stimulation, mediates GABA release at nerve terminals, and regulates anxiety and alcohol consumption...
  14. ncbi request reprint Acute exposure to CXC chemokine ligand 10, but not its chronic astroglial production, alters synaptic plasticity in mouse hippocampal slices
    Roman Vlkolinsky
    Department of Neuropharmacology, CVN 12, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    J Neuroimmunol 150:37-47. 2004
    ..The effect was probably receptor-mediated because CXCL10-induced inhibition of LTP was not observed in CXCR3 KO mice. Our findings suggest that acute exposure to CXCL10 alters synaptic plasticity via CXCR3 in mouse hippocampus...
  15. ncbi request reprint Cortistatin overexpression in transgenic mice produces deficits in synaptic plasticity and learning
    Melanie K Tallent
    Department of Pharmacology and Physiology, Drexel University, University College of Medicine, Philadelphia, PA 19102, USA
    Mol Cell Neurosci 30:465-75. 2005
    ..Our findings implicate cortistatin in the modulation of synaptic plasticity and cognitive function. Thus, increases in hippocampal cortistatin expression during aging could have an impact on age-related cognitive deficits...
  16. ncbi request reprint Galanin alters GABAergic neurotransmission in the dorsal raphe nucleus
    Lisa M Sharkey
    Molecular and Integrative Neurosciences Department, The Harold L Dorris Neurological Research Center, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Neurochem Res 33:285-91. 2008
    ..These findings may enhance understanding of the cellular mechanisms underlying the effects of antidepressant treatments on galanin and galanin receptors in DRN...

Research Grants25

  1. MORPHINE-LIKE BRAIN PEPTIDES--CELLULAR NEUROBIOLOGY
    GEORGE SIGGINS; Fiscal Year: 1993
    ..These studies should help more clearly specify the role of opioid peptides and their receptors in normal, opiate-seeking and opiate addictive-tolerant behavior, and help to provide a cellular basis for therapeusis of "craving."..
  2. MORPHINE LIKE BRAIN PEPTIDES--CELLULAR NEUROBIOLOGY
    GEORGE SIGGINS; Fiscal Year: 2003
    ..abstract_text> ..
  3. SOMATOSTATIN RELATED PEPTIDES AND BRAIN FUNCTION
    GEORGE SIGGINS; Fiscal Year: 2003
    ..abstract_text> ..
  4. Morphine Like Brain Peptides-Cellular Neurobiology
    GEORGE SIGGINS; Fiscal Year: 2007
    ..These studies may help define the role of opioids and their receptors in behavior and provide rational targets for therapeusis of opiate "craving. ..
  5. Electrophysiology of alcohol in extended amygdala
    GEORGE SIGGINS; Fiscal Year: 2007
    ....
  6. MORPHINE-LIKE BRAIN PEPTIDES--CELLULAR NEUROBIOLOGY
    GEORGE SIGGINS; Fiscal Year: 1992
    ..These studies should help more clearly specify the role of opioid peptides and their receptors in normal, opiate-seeking and opiate addictive-tolerant behavior, perhaps provide a cellular basis for therapeusis of "craving"...