SAID SIF

Summary

Affiliation: The Ohio State University
Country: USA

Publications

  1. ncbi request reprint ATP-dependent nucleosome remodeling complexes: enzymes tailored to deal with chromatin
    SAID SIF
    Department of Molecular and Cellular Biochemistry, College of Medicine and Public Health, The Ohio State University, Columbus, Ohio 43210, USA
    J Cell Biochem 91:1087-98. 2004
  2. pmc Purification and characterization of mSin3A-containing Brg1 and hBrm chromatin remodeling complexes
    S Sif
    Department of Molecular Biology, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    Genes Dev 15:603-18. 2001
  3. pmc Defective co-activator recruitment in osteoclasts from microphthalmia-oak ridge mutant mice
    Sudarshana M Sharma
    Department of Molecular and Cellular Biochemistry, Comprehensive Cancer Center, The Ohio State University, Columbus, Ohio, USA
    J Cell Physiol 220:230-7. 2009
  4. pmc Human SWI/SNF-associated PRMT5 methylates histone H3 arginine 8 and negatively regulates expression of ST7 and NM23 tumor suppressor genes
    Sharmistha Pal
    Department of Molecular and Cellular Biochemistry, Ohio State University College of Medicine, Columbus, OH 43210, USA
    Mol Cell Biol 24:9630-45. 2004
  5. ncbi request reprint Interplay between chromatin remodelers and protein arginine methyltransferases
    Sharmistha Pal
    Department of Molecular and Cellular Biochemistry, College of Medicine, The Ohio State University, Columbus, Ohio 43210, USA
    J Cell Physiol 213:306-15. 2007
  6. pmc Protein arginine methyltransferase 5 suppresses the transcription of the RB family of tumor suppressors in leukemia and lymphoma cells
    Li Wang
    Department of Molecular and Cellular Biochemistry, Ohio State University College of Medicine, Columbus, OH 43210, USA
    Mol Cell Biol 28:6262-77. 2008
  7. pmc Protein arginine methyltransferase 7 regulates cellular response to DNA damage by methylating promoter histones H2A and H4 of the polymerase δ catalytic subunit gene, POLD1
    Vrajesh Karkhanis
    Department of Molecular and Cellular Biochemistry, College of Medicine, Ohio State University, Columbus, OH 43210, USA
    J Biol Chem 287:29801-14. 2012
  8. pmc Bromodomain protein 7 interacts with PRMT5 and PRC2, and is involved in transcriptional repression of their target genes
    Sookil Tae
    Department of Molecular and Cellular Biochemistry, College of Medicine, The Ohio State University, Columbus, Ohio, OH 43210, USA
    Nucleic Acids Res 39:5424-38. 2011
  9. pmc mSin3A/histone deacetylase 2- and PRMT5-containing Brg1 complex is involved in transcriptional repression of the Myc target gene cad
    Sharmistha Pal
    Department of Molecular and Cellular Biochemistry, College of Medicine and Public Health, The Ohio State University, Columbus, Ohio 43210, USA
    Mol Cell Biol 23:7475-87. 2003
  10. ncbi request reprint Reconstitution of a core chromatin remodeling complex from SWI/SNF subunits
    M L Phelan
    Department of Molecular Biology, Massachusetts General Hospital, Boston 02114, USA
    Mol Cell 3:247-53. 1999

Collaborators

  • Li Wang
  • Anthony N Imbalzano
  • Michael R Grever
  • Sarmila Majumder
  • Antara Datta
  • R E Kingston
  • Yingjie Zhang
  • Y Nakatani
  • S Huang
  • Joomyeong Kim
  • Sharmistha Pal
  • Vrajesh Karkhanis
  • Sudarshana M Sharma
  • Sookil Tae
  • Hediye Erdjument-Bromage
  • Paul Tempst
  • Yu Jie Hu
  • Robert A Baiocchi
  • Michael C Ostrowski
  • M Fuchs
  • E K Sullivan
  • K A Piffat
  • Kevin Velasco
  • Mariana Yaneva
  • J DiRenzo
  • Uma Sankar
  • M L Phelan
  • Samson T Jacob
  • Kim C Mansky
  • Agnieszka Bronisz
  • Krupen Patel
  • Rong Hu
  • John C Byrd
  • Sheethal N Vishwanath
  • Lynne Lacomis
  • Jitendra Kumar
  • Romy Yun
  • R Drapkin
  • T D Gilmore
  • D M Livingston
  • A Liss
  • V Ogryzko
  • J R Guyon
  • C S Weirich
  • T Ikura
  • J Nehyba
  • T Ikeda
  • W S Lane
  • R Hrdlickova
  • H R Bose
  • J Gerber
  • M Brown
  • Y Shang
  • M Phelan
  • M Myers
  • G J Narlikar

Detail Information

Publications22

  1. ncbi request reprint ATP-dependent nucleosome remodeling complexes: enzymes tailored to deal with chromatin
    SAID SIF
    Department of Molecular and Cellular Biochemistry, College of Medicine and Public Health, The Ohio State University, Columbus, Ohio 43210, USA
    J Cell Biochem 91:1087-98. 2004
    ....
  2. pmc Purification and characterization of mSin3A-containing Brg1 and hBrm chromatin remodeling complexes
    S Sif
    Department of Molecular Biology, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    Genes Dev 15:603-18. 2001
    ..These unexpected functional characteristics indicate that these hSWI/SNF complexes play diverse regulatory roles...
  3. pmc Defective co-activator recruitment in osteoclasts from microphthalmia-oak ridge mutant mice
    Sudarshana M Sharma
    Department of Molecular and Cellular Biochemistry, Comprehensive Cancer Center, The Ohio State University, Columbus, Ohio, USA
    J Cell Physiol 220:230-7. 2009
    ..Cathepsin K may thus represent a unique class of Mitf-regulated osteoclast-specific genes that are important for osteoclast function...
  4. pmc Human SWI/SNF-associated PRMT5 methylates histone H3 arginine 8 and negatively regulates expression of ST7 and NM23 tumor suppressor genes
    Sharmistha Pal
    Department of Molecular and Cellular Biochemistry, Ohio State University College of Medicine, Columbus, OH 43210, USA
    Mol Cell Biol 24:9630-45. 2004
    ..These findings suggest that the BRG1- and hBRM-associated PRMT5 regulates cell growth and proliferation by controlling expression of genes involved in tumor suppression...
  5. ncbi request reprint Interplay between chromatin remodelers and protein arginine methyltransferases
    Sharmistha Pal
    Department of Molecular and Cellular Biochemistry, College of Medicine, The Ohio State University, Columbus, Ohio 43210, USA
    J Cell Physiol 213:306-15. 2007
    ..In this review, we will focus on the latest findings and biological roles of ATP-dependent chromatin remodeling complexes and PRMT enzymes, and how their aberrant expression is linked to cancer...
  6. pmc Protein arginine methyltransferase 5 suppresses the transcription of the RB family of tumor suppressors in leukemia and lymphoma cells
    Li Wang
    Department of Molecular and Cellular Biochemistry, Ohio State University College of Medicine, Columbus, OH 43210, USA
    Mol Cell Biol 28:6262-77. 2008
    ....
  7. pmc Protein arginine methyltransferase 7 regulates cellular response to DNA damage by methylating promoter histones H2A and H4 of the polymerase δ catalytic subunit gene, POLD1
    Vrajesh Karkhanis
    Department of Molecular and Cellular Biochemistry, College of Medicine, Ohio State University, Columbus, OH 43210, USA
    J Biol Chem 287:29801-14. 2012
    ..These results provide evidence for the important role played by PRMT7 in epigenetic regulation of DNA repair genes and cellular response to DNA damage...
  8. pmc Bromodomain protein 7 interacts with PRMT5 and PRC2, and is involved in transcriptional repression of their target genes
    Sookil Tae
    Department of Molecular and Cellular Biochemistry, College of Medicine, The Ohio State University, Columbus, Ohio, OH 43210, USA
    Nucleic Acids Res 39:5424-38. 2011
    ..These findings highlight the role played by BRD7 in PRMT5- and PRC2-induced transcriptional silencing, and indicate that recruitment of specific RDMs and KDMs is required for efficient transcriptional derepression...
  9. pmc mSin3A/histone deacetylase 2- and PRMT5-containing Brg1 complex is involved in transcriptional repression of the Myc target gene cad
    Sharmistha Pal
    Department of Molecular and Cellular Biochemistry, College of Medicine and Public Health, The Ohio State University, Columbus, Ohio 43210, USA
    Mol Cell Biol 23:7475-87. 2003
    ..These results suggest that hSWI/SNF complexes, through their ability to interact with activator and repressor proteins, control expression of genes involved in cell growth and proliferation...
  10. ncbi request reprint Reconstitution of a core chromatin remodeling complex from SWI/SNF subunits
    M L Phelan
    Department of Molecular Biology, Massachusetts General Hospital, Boston 02114, USA
    Mol Cell 3:247-53. 1999
    ..The addition of INI1, BAF155, and BAF170 to BRG1 increases remodeling activity to a level comparable to that of the whole hSWI/SNF complex. These data define the functional core of the hSWI/SNF complex...
  11. pmc The BRG1- and hBRM-associated factor BAF57 induces apoptosis by stimulating expression of the cylindromatosis tumor suppressor gene
    Li Wang
    Department of Molecular and Cellular Biochemistry, Ohio State University College of Medicine, 1645 Neil Ave, Columbus, OH 43210, USA
    Mol Cell Biol 25:7953-65. 2005
    ..These findings demonstrate the importance of BAF57 in cell growth regulation and provide a novel link between hSWI/SNF chromatin remodelers and apoptosis...
  12. pmc Versatility of PRMT5-induced methylation in growth control and development
    Vrajesh Karkhanis
    Department of Molecular and Cellular Biochemistry, College of Medicine, The Ohio State University, Columbus, OH 43210, USA
    Trends Biochem Sci 36:633-41. 2011
    ..These studies not only provide insight into the molecular mechanisms by which PRMT5 contributes to growth control, but also justify therapeutic targeting of PRMT5...
  13. pmc Methylation of histone H3 and H4 by PRMT5 regulates ribosomal RNA gene transcription
    Sarmila Majumder
    Department of Molecular and Cellular Biochemistry, Ohio State University, Columbus, Ohio 43210, USA
    J Cell Biochem 109:553-63. 2010
    ..These data suggest a key role of PRMT5 and the two methylated histones in regulating rRNA promoter activity...
  14. pmc Low levels of miR-92b/96 induce PRMT5 translation and H3R8/H4R3 methylation in mantle cell lymphoma
    Sharmistha Pal
    Department of Molecular and Cellular Biochemistry, The Ohio State University, Columbus, OH 43210, USA
    EMBO J 26:3558-69. 2007
    ..Thus, our studies indicate that aberrant expression of PRMT5 leads to altered epigenetic modification of chromatin, which in turn impacts transcriptional performance of anti-cancer genes and growth of transformed lymphoid cells...
  15. ncbi request reprint Ikaros DNA-binding proteins direct formation of chromatin remodeling complexes in lymphocytes
    J Kim
    Cutaneous Biology Research Center, Massachusetts General Hospital, Harvard Medical School, Charlestown 02129, USA
    Immunity 10:345-55. 1999
    ..These studies reveal that Ikaros proteins are capable of targeting chromatin remodeling and deacetylation complexes in vivo. We propose that the restructuring of chromatin is a key aspect of Ikaros function in lymphocyte differentiation...
  16. pmc BRG-1 is recruited to estrogen-responsive promoters and cooperates with factors involved in histone acetylation
    J DiRenzo
    Department of Adult Oncology, Dana Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02115, USA
    Mol Cell Biol 20:7541-9. 2000
    ....
  17. ncbi request reprint The mouse C/EBPdelta gene promoter is regulated by STAT3 and Sp1 transcriptional activators, chromatin remodeling and c-Myc repression
    Yingjie Zhang
    Department of Veterinary Biosciences, Ohio State University, Columbus, Ohio 43210, USA
    J Cell Biochem 102:1256-70. 2007
    ..These results provide a molecular model of C/EBPdelta transcriptional regulation under G(0) growth arrest conditions...
  18. pmc Mitotic inactivation of a human SWI/SNF chromatin remodeling complex
    S Sif
    Department of Molecular Biology, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    Genes Dev 12:2842-51. 1998
    ..We propose that this transitional inactivation and reactivation of hSWI/SNF is required for formation of a repressed chromatin structure during mitosis and reformation of an active chromatin structure as cells leave mitosis...
  19. pmc Transcriptional activation domains of human heat shock factor 1 recruit human SWI/SNF
    E K Sullivan
    Department of Molecular Biology, Massachusetts General Hospital, Boston, MA 02114, USA
    Mol Cell Biol 21:5826-37. 2001
    ....
  20. ncbi request reprint MITF and PU.1 recruit p38 MAPK and NFATc1 to target genes during osteoclast differentiation
    Sudarshana M Sharma
    Department of Molecular and Cellular Biochemistry and the Comprehensive Cancer Center, Ohio State University, Columbus, Ohio 43210, USA
    J Biol Chem 282:15921-9. 2007
    ..1 as nuclear effectors that integrate CSF-1/RANKL signals during osteoclast differentiation to initiate expression of target genes, whereas a complex that includes NFATc1 may act to maintain target gene expression in differentiated cells...
  21. ncbi request reprint The p400 complex is an essential E1A transformation target
    M Fuchs
    Dana Farber Cancer Institute, Boston, MA, USA
    Cell 106:297-307. 2001
    ..Furthermore, E1A and c-myc each alter the subunit composition of p400 complexes, implying that physiological p400 complex formation contributes to transformation suppression...
  22. ncbi request reprint The chicken RelB transcription factor has transactivation sequences and a tissue-specific expression pattern that are distinct from mammalian RelB
    K A Piffat
    Department of Biology, Boston University, Boston, Massachusetts 02215, USA
    Mol Cell Biol Res Commun 4:266-75. 2001
    ..Thus, chicken RelB has functional properties similar to other vertebrate RelB proteins. However, Western blotting of diverse chicken tissues indicates that chicken RelB is more widely expressed than mammalian RelB...

Research Grants6

  1. ROLE OF CHROMATIN REMODELERS IN B AND T CELL DEVELOPMENT
    SAID SIF; Fiscal Year: 2004
    ..abstract_text> ..
  2. Effects of human SWI/SNF-associated PRMT5 on lymphomagenesis
    SAID SIF; Fiscal Year: 2007
    ....
  3. Effects of human SWI/SNF-associated PRMT5 on lymphomagenesis
    SAID SIF; Fiscal Year: 2011
    ..abstract_text> ..