Affiliation: The University of Texas
Liu Y, Deguchi Y, Tian R, Wei D, Wu L, Chen W, et al
. Pleiotropic Effects of PPARD Accelerate Colorectal Tumorigenesis, Progression, and Invasion. Cancer Res. 2019;79:954-969 pubmed publisher
Mao F, Xu M, Zuo X, Yu J, Xu W, Moussalli M, et al
. 15-Lipoxygenase-1 suppression of colitis-associated colon cancer through inhibition of the IL-6/STAT3 signaling pathway. FASEB J. 2015;29:2359-70 pubmed publisher
..25 in 15-LOX-1-PPAR-Î´-Gut mice (P = 0.0006). Identification of 15-LOX-1 suppression of PPAR-Î´ to inhibit IL-6/STAT3 signaling-driven CAC tumorigenesis provides mechanistic insights that can be used to molecularly target CAC. ..
Xu M, Zuo X, Shureiqi I. Targeting peroxisome proliferator-activated receptor-β/δ in colon cancer: how to aim?. Biochem Pharmacol. 2013;85:607-611 pubmed publisher
..Definitive studies are therefore needed to establish the exact role of PPARδ in human colorectal tumorigenesis and to provide a theoretical basis for PPARδ therapeutic targeting. ..
Liu Y, Colby J, Zuo X, Jaoude J, Wei D, Shureiqi I. The Role of PPAR-δ in Metabolism, Inflammation, and Cancer: Many Characters of a Critical Transcription Factor. Int J Mol Sci. 2018;19: pubmed publisher
..This review discusses the complex relationship between PPAR-δ in health and disease and highlights our current knowledge regarding the different roles that PPAR-δ plays in metabolism, inflammation, and cancer. ..
Colby J, Jaoude J, Liu F, Shureiqi I. Oxygenated lipid signaling in tumor-associated macrophages-focus on colon cancer. Cancer Metastasis Rev. 2018;37:289-315 pubmed publisher
..The purpose of this review is to give an overview of what is currently known regarding PUFA-derived mediator signaling in tumor-associated macrophages in CRC. ..
Shureiqi I, Jiang W, Fischer S, Xu X, Chen D, Lee J, et al
. GATA-6 transcriptional regulation of 15-lipoxygenase-1 during NSAID-induced apoptosis in colorectal cancer cells. Cancer Res. 2002;62:1178-83 pubmed
..Ectopic GATA-6 expression blocked NSAID induction of 15-LOX-1 and apoptosis. NSAIDs down-regulate GATA-6 to transcriptionally up-regulate 15-LOX-1 and induce apoptosis in colorectal cancer cells. ..
Shureiqi I, Zuo X, Broaddus R, Wu Y, Guan B, Morris J, et al
. The transcription factor GATA-6 is overexpressed in vivo and contributes to silencing 15-LOX-1 in vitro in human colon cancer. FASEB J. 2007;21:743-53 pubmed
..Maintaining 15-LOX-1 transcriptional silencing in cancer cells is a multifactorial process involving GATA-6 overexpression and other regulatory events. ..
Shureiqi I. Molecular Predicators of Duodenal Familial Adenomatous Polyposis Chemoprevention: Do Chemopreventive Drugs Hit Their Presumed Molecular Targets?. Cancer Prev Res (Phila). 2018;11:1-3 pubmed publisher
..This perspective discusses the significance and limitations of the study. Cancer Prev Res; 11(1); 1-3. ©2017 AACRSee related article by Delker et al., p. 4. ..
Shureiqi I, Jiang W, Zuo X, Wu Y, Stimmel J, Leesnitzer L, et al
. The 15-lipoxygenase-1 product 13-S-hydroxyoctadecadienoic acid down-regulates PPAR-delta to induce apoptosis in colorectal cancer cells. Proc Natl Acad Sci U S A. 2003;100:9968-73 pubmed
..Our findings indicate that the down-regulation of PPAR-delta by 15-LOX-1 through 13-S-HODE is an apoptotic signaling pathway that is activated by NSAIDs. ..