Research Topics
Genomes and Genes
| Leonard D ShultzSummaryAffiliation: The Jackson Laboratory Country: USA Publications
| Collaborators
|
Detail Information
Publications
NOD/LtSz-Rag1null mice: an immunodeficient and radioresistant model for engraftment of human hematolymphoid cells, HIV infection, and adoptive transfer of NOD mouse diabetogenic T cellsL D Shultz
The Jackson Laboratory, Bar Harbor, ME 04609, USA
J Immunol 164:2496-507. 2000..These data demonstrate the advantages of NOD/LtSz-Rag1null mice as a radiation and lymphoma-resistant model for long-term analyses of engrafted human hematolymphoid cells or diabetogenic NOD lymphoid cells...- NOD/LtSz-Rag1nullPfpnull mice: a new model system with increased levels of human peripheral leukocyte and hematopoietic stem-cell engraftmentLeonard D Shultz
The Jackson Laboratory, Bar Harbor, ME 04609, USA
Transplantation 76:1036-42. 2003.... - Mutations at the mouse ichthyosis locus are within the lamin B receptor gene: a single gene model for human Pelger-Huët anomalyLeonard D Shultz
The Jackson Laboratory, Bar Harbor, ME 04609, USA
Hum Mol Genet 12:61-9. 2003..These spontaneous Lbr mutations confirm the molecular basis of human PHA and provide a small animal model for determination of the precise function of LBR in normal and pathological states... - Regulation of human short-term repopulating cell (STRC) engraftment in NOD/SCID mice by host CD122+ cellsLeonard D Shultz
The Jackson Laboratory, 600 Main Street, Bar Harbor, Maine 04609, USA
Exp Hematol 31:551-8. 2003..The objective of these studies was to deplete NK cells both by genetic manipulation of the hosts and by antibody depletion of cell populations that may regulate engraftment with human STRC... - Humanized mice in translational biomedical researchLeonard D Shultz
The Jackson Laboratory, 600 Main Street, Bar Harbor, Maine 04609, USA
Nat Rev Immunol 7:118-30. 2007.... - Mechanisms of anemia in SHP-1 protein tyrosine phosphatase-deficient "viable motheaten" miceBonnie L Lyons
The Jackson Laboratory, Bar Harbor, ME 04609, USA
Exp Hematol 31:234-43. 2003..The aim of this study was to investigate the mechanisms underlying anemia in me(v)/me(v) mice... - Human lymphoid and myeloid cell development in NOD/LtSz-scid IL2R gamma null mice engrafted with mobilized human hemopoietic stem cellsLeonard D Shultz
The Jackson Laboratory, Bar Harbor, ME 04609, USA
J Immunol 174:6477-89. 2005..Thus, NOD-scid IL2Rgamma(null) mice engrafted with human mobilized blood stem cells provide a new in vivo long-lived model of robust multilineage human HSC engraftment... - Absence of CD5 dramatically reduces progression of pulmonary inflammatory lesions in SHP-1 protein-tyrosine phosphatase-deficient 'viable motheaten' miceMelissa J Joliat
The Jackson Laboratory, Bar Harbor, ME 04609, USA
J Autoimmun 18:105-17. 2002..Study of CD5(null)me(v)/ me(v) mice may provide further insight into the role of CD5 in cell signaling and may help explain the observed association of CD5(+) B-cells with autoimmune disease... - Multiple defects in innate and adaptive immunologic function in NOD/LtSz-scid miceL D Shultz
Jackson Laboratory, Bar Harbor, ME 04609
J Immunol 154:180-91. 1995..B-17/Sz-scid/scid animals. The multiple defects in innate and adaptive immunity unique to the NOD/LtSz-scid/scid mouse provide an excellent in vivo environment for reconstitution with human hematopoietic cells... - Genetic disassociation of autoimmunity and resistance to costimulation blockade-induced transplantation tolerance in nonobese diabetic miceTodd Pearson
Program in Immunology and Virology, University of Massachusetts Medical School, Worcester, MA 01655, USA
J Immunol 171:185-95. 2003..The outcomes of tolerance induction protocols tested in NOD mice may not accurately predict outcomes in human subjects... - T cell developmental defects in 'viable motheaten' mice deficient in SHP-1 protein-tyrosine phosphatase. Developmental defects are corrected in vitro in the presence of normal hematopoietic-origin stromal cells and in vivo by exogenous IL-7Sherri W Christianson
The Jackson Laboratory, 600 Main Street, Bar Harbor, ME 04609, USA
J Autoimmun 18:119-30. 2002..We conclude that abnormal T cell development in me(v)/ me(v) mice may in part be due to defects in the ability of bone marrow-derived accessory cells to provide bioavailable IL-7 to developing thymocytes... 
The mouse mutation "thrombocytopenia and cardiomyopathy" (trac) disrupts Abcg5: a spontaneous single gene model for human hereditary phytosterolemia/sitosterolemiaThomas H Chase
The Jackson Laboratory, Bar Harbor, ME, USA
Blood 115:1267-76. 2010..The trac mutation provides a new clinically significant animal model for human phytosterolemia and provides a new means for studying the role of phytosterols in hematologic diseases and testing therapeutic interventions...- Development of functional human blood and immune systems in NOD/SCID/IL2 receptor {gamma} chain(null) miceFumihiko Ishikawa
Department of Cancer Immunology and AIDS, Dana Farber Cancer Institute, 44 Binney St, no 770, Boston, MA 02115, USA
Blood 106:1565-73. 2005..Thus, the NOD/SCID/IL2rgamma(null) newborn system might be an important experimental model to study the human hemato-lymphoid system... - Deficiency of SHP-1 protein-tyrosine phosphatase in "viable motheaten" mice results in retinal degenerationBonnie L Lyons
The Jackson Laboratory, Bar Harbor, Maine 04609, USA
Invest Ophthalmol Vis Sci 47:1201-9. 2006..These mice exhibit immune dysfunction, hyperproliferation of myeloid cells, and regenerative anemia. This study focused on the role of SHP-1 in retinal homeostasis... - Establishment and characterization of a new osteogenic cell line (MOS-J) from a spontaneous C57BL/6J mouse osteosarcomaMelissa J Joliat
Jackson Laboratory, 600 Main Street, Bar Harbor, ME 04609, USA
In Vivo 16:223-8. 2002..These characteristics indicate the potential utility of the MOS-J osteosarcoma cell line as a model for studies of human osteosarcoma and bone biology... - Generation of functional human T-cell subsets with HLA-restricted immune responses in HLA class I expressing NOD/SCID/IL2r gamma(null) humanized miceLeonard D Shultz
The Jackson Laboratory, Bar Harbor, ME 04609
Proc Natl Acad Sci U S A 107:13022-7. 2010.... - Long-term engraftment and expansion of tumor-derived memory T cells following the implantation of non-disrupted pieces of human lung tumor into NOD-scid IL2Rgamma(null) miceMichelle R Simpson-Abelson
State University of New York, Department of Microbiology and Immunology and The Witebsky Center for Microbial Pathogenesis and Immunology, University at Buffalo, Buffalo, NY 14214, USA
J Immunol 180:7009-18. 2008..We conclude that the NOD-scid IL2Rgamma(null) tumor xenograft model provides an opportunity to study tumor and tumor-stromal cell interactions in situ for prolonged periods... - Prolonged survival of neonatal porcine islet xenografts in mice treated with a donor-specific transfusion and anti-CD154 antibodyMichael C Appel
Department of Medicine, Division of Diabetes, University of Massachusetts Medical School, Worcester, MA 01605, USA
Transplantation 77:1341-9. 2004.... - Rejection of human islets and human HLA-A2.1 transgenic mouse islets by alloreactive human lymphocytes in immunodeficient NOD-scid and NOD-Rag1(null)Prf1(null) miceScott J Banuelos
Department of Surgery, University of Massachusetts Medical School, Worcester, MA 01605, USA
Clin Immunol 112:273-83. 2004..host disease (GVHD). We propose that diabetic NOD-RagI(null)Prf1(null) mice co-engrafted with HLA-A2 mouse transgenic islets and allogeneic human PBMC provide an effective in vivo model of human islet allograft rejection... - Epidermal dendritic cell populations in the flaky skin mutant mouseJ P Sundberg
Jackson Laboratory, Bar Harbor, ME 04609
Immunol Invest 22:389-401. 1993..These studies suggest that the psoriasiform dermatitis in the flaky skin mouse mutation is associated with abnormalities at the level of hematopoietic progenitor cells... - The flaky skin (fsn) mutation in mice: map location and description of the anemiaW G Beamer
Jackson Laboratory, Bar Harbor, ME 04609 1500, USA
Blood 86:3220-6. 1995..The mechanism whereby fsn induces the reported pleiotropic effects has yet to be elucidated... - Creation of "humanized" mice to study human immunityTodd Pearson
Diabetes Division, University of Massachusetts Medical School, Worcester, Massachusetts, USA
Curr Protoc Immunol . 2008.... - Cancer stem cells are enriched in the side population cells in a mouse model of gliomaMolly A Harris
The Jackson Laboratory, Bar Harbor, Maine 04609, USA
Cancer Res 68:10051-9. 2008..In conclusion, this study shows that CSCs exist in a mouse glioma model, suggesting that this model can be used to study the molecular and cellular characteristics of CSCs in vivo and to further test the CSC hypothesis... - Accelerated wound healing of alkali-burned corneas in MRL mice is associated with a reduced inflammatory signatureMotonobu Ueno
Jackson Laboratory, Bar Harbor, ME 04609, USA
Invest Ophthalmol Vis Sci 46:4097-106. 2005..However, the rapid-healing phenotype is not intrinsic to MRL hematopoietic progenitor cells... - T cell-specific siRNA delivery suppresses HIV-1 infection in humanized micePriti Kumar
Immune Disease Institute and Department of Pediatrics, Harvard Medical School, Boston, MA 02115, USA
Cell 134:577-86. 2008..Moreover, scFvCD7-9R could deliver antiviral siRNAs to naive T cells in Hu-HSC mice and effectively suppress viremia in infected mice. Thus, siRNA therapy for HIV infection appears to be feasible in a preclinical animal model... - Evaluation of donor-specific transfusion sources: unique failure of bone marrow cells to induce prolonged skin allograft survival with anti-CD154 monoclonal antibodyThomas G Markees
Department of Medicine, University of Massachusetts Medical School, Worcester, MA 01605, USA
Transplantation 78:1601-8. 2004..It is unknown if other lymphohematopoietic cell populations can be used as a DST... - Development of new-generation HU-PBMC-NOD/SCID mice to study human islet alloreactivityMarie King
Diabetes Division, University of Massachusetts Medical School, 373 Plantation Street, Suite 218, Worcester, MA 01605, USA
Ann N Y Acad Sci 1103:90-3. 2007..Herein, we describe the challenges of recapitulating human immunity in humanized mice and features of NOD-scid Il2rgamma(null) mice that help overcome them... - Anti-mouse CD154 antibody treatment facilitates generation of mixed xenogeneic rat hematopoietic chimerism, prevents wasting disease and prolongs xenograft survival in miceHideyuki Masaki
Division of Diabetes, University of Massachusetts Medical School, Worcester, MA, USA
Xenotransplantation 13:224-32. 2006..The goal of this study was to determine if co-stimulation blockade would facilitate chimerism and xenograft tolerance in irradiation-conditioned concordant recipients... - In childhood acute lymphoblastic leukemia, blasts at different stages of immunophenotypic maturation have stem cell propertiesChristoph le Viseur
Department of Pediatric Hematology and Oncology, University Children s Hospital Munster, 48129 Munster, Germany
Cancer Cell 14:47-58. 2008..Sorted blast populations mirrored normal B precursor cells with transcription of a number of stage-appropriate genes. These observations inform a model for leukemia-propagating stem cells in childhood ALL... - Expanded CD34+ human umbilical cord blood cells generate multiple lymphohematopoietic lineages in NOD-scid IL2rgamma(null) miceLisa J Giassi
Division of Diabetes, Department of Medicine, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
Exp Biol Med (Maywood) 233:997-1012. 2008..Ex vivo expanded CD34(+) human UCB cells have the capacity to generate multiple hematopoietic lineages and a functional human immune system upon transplantation into TNFalpha-treated NOD-scid IL2rgamma(null) mice... - Dysferlin deficiency and the development of cardiomyopathy in a mouse model of limb-girdle muscular dystrophy 2BThomas H Chase
The Jackson Laboratory, Bar Harbor, Maine 04609, USA
Am J Pathol 175:2299-308. 2009..This damage results in transient functional deficits at 10 months of age, but, unlike in skeletal muscle, the cell injury is sublethal and causes only mild cardiomyopathy even at advanced ages... - Emv30null NOD-scid mice. An improved host for adoptive transfer of autoimmune diabetes and growth of human lymphohematopoietic cellsD V Serreze
Jackson Laboratory, Bar Harbor, Maine 04609, USA
Diabetes 44:1392-8. 1995..Significantly, the ability of standard NOD T-cells to transfer IDDM to the Emv30null NOD-scid stock was not impaired.(ABSTRACT TRUNCATED AT 250 WORDS).. - An assay for human hematopoietic stem cells based on transplantation into nonobese diabetic recombination activating gene-null perforin-null miceHitoshi Minamiguchi
Department of Veterans Affairs Medical Center, Medical University of South Carolina, Charleston, South Carolina 29401-5799, USA
Biol Blood Marrow Transplant 11:487-94. 2005..Accordingly, conditioned newborn NOD- Rag1 null Prf1 null mice provide a desirable model for an assay of long-term transplantable human HSCs... - Regulation of skin and islet allograft survival in mice treated with costimulation blockade is mediated by different CD4+ cell subsets and different mechanismsScott J Banuelos
Department of Surgery, University of Massachusetts Medical School, 373 Plantation Street, Worcester, MA 01605, USA
Transplantation 78:660-7. 2004..It appears that skin and islet transplantation tolerance are mediated by different CD4 cell subsets and different mechanisms... - TLR agonists abrogate costimulation blockade-induced prolongation of skin allograftsThomas B Thornley
Division of Diabetes, Department of Medicine, University of Massachusetts Medical School, Worcester, MA 01605, USA
J Immunol 176:1561-70. 2006..We conclude that TLR signaling abrogates the effects of costimulation blockade by preventing alloreactive CD8+ T cell apoptosis through a mechanism not dependent on TNFR2 or IL-12R signaling... - Human cord blood--derived cells generate insulin-producing cells in vivoShuro Yoshida
Department of Medicine and Biosystemic Science, Kyushu University Graduate School of Medicine, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan
Stem Cells 23:1409-16. 2005..Taken together, human CB contains progenitor cells, which can generate insulin-producing cells in recipient pancreatic tissues across a xenogeneic histocompatibility barrier by fusion-dependent and -independent mechanisms... - Alloimmune injury and rejection of human skin grafts on human peripheral blood lymphocyte-reconstituted non-obese diabetic severe combined immunodeficient beta2-microglobulin-null miceNicole A Turgeon
University of Massachusetts Medical School, Worcester, Massachussetts 01605, USA
Exp Biol Med (Maywood) 228:1096-104. 2003..It is proposed that Hu-PBL-NOD-scid B2mnull mice engrafted with human skin will provide a useful model for analysis of interventions designed to modulate human allograft rejection... - A new Hu-PBL model for the study of human islet alloreactivity based on NOD-scid mice bearing a targeted mutation in the IL-2 receptor gamma chain geneMarie King
Department of Medicine, University of Massachusetts Medical School, 373 Plantation Street, Worcester, MA 01655, USA
Clin Immunol 126:303-14. 2008..These data suggest that humanized NOD-scid Il2rgamma(null) mice may represent an important surrogate for investigating in vivo mechanisms of human islet allograft rejection... - Dystrophin and dysferlin double mutant mice: a novel model for rhabdomyosarcomaVishnu Hosur
The Jackson Laboratory, Bar Harbor, ME, USA
Cancer Genet 205:232-41. 2012..The present finding bolsters the correlation between MD and sarcomas, and provides a model not only to examine the cellular origins but also to identify mechanisms and signal transduction pathways triggering development of RMS... - Severe defects in immunity and hematopoiesis caused by SHP-1 protein-tyrosine-phosphatase deficiencyL D Shultz
Jackson Laboratory, Bar Harbor, ME 04609, USA
Trends Biotechnol 15:302-7. 1997..This natural model for a specific protein-tyrosine-phosphatase deficiency is being widely utilized to determine the role of SHP-1 in the negative regulation of multiple signaling pathways in a number of hematopoietic lineages... - Lanceolate hair-J (lahJ): a mouse model for human hair disordersJ P Sundberg
The Jackson Laboratory, Bar Harbor, Maine 04609 1500, USA
Exp Dermatol 9:206-18. 2000..Homozygotes for either of these allelic mouse mutations have elevated serum IgE levels, a feature also common with human Netherton's syndrome... - Spontaneous mutations in the mouse Sharpin gene result in multiorgan inflammation, immune system dysregulation and dermatitisR E Seymour
The Jackson Laboratory, Bar Harbor, ME 04609, USA
Genes Immun 8:416-21. 2007..These are the first examples of disease-causing mutations in the Sharpin gene and demonstrate the importance of SHARPIN protein in normal immune development and control of inflammation... - The nonobese diabetic scid mouse: model for spontaneous thymomagenesis associated with immunodeficiencyM Prochazka
Jackson Laboratory, Bar Harbor, ME 04609
Proc Natl Acad Sci U S A 89:3290-4. 1992..We propose that the unusual features of T-cell ontogeny characteristic of the NOD inbred strain synergize with the scid-imparted block in thymocyte development, leading to activation of the NOD-unique Emv-30 to initiate thymomagenesis... - Multiple low-dose streptozocin-induced diabetes in NOD-scid/scid mice in the absence of functional lymphocytesI C Gerling
Jackson Laboratory, Bar Harbor, ME 04609
Diabetes 43:433-40. 1994..We conclude that IDDM induced by MD-STZ is not mediated by T-cell- or B-cell-dependent autoimmune mechanisms in a fashion analogous to the spontaneous IDDM characteristic of NOD mice... - Expression of terminal differentiation proteins defines stages of mouse mammary gland developmentI Mikaelian
Igor Mikaelian, Box 98, The Jackson Laboratory, 600 Main Street, Bar Harbor, ME 04609 1500, USA
Vet Pathol 43:36-49. 2006..Finally, consistent with results of earlier studies, keratins 1, 10, 13, and 15, and filaggrin, involucrin, and loricrin were not detected at any stage of mammary gland development... - CSF-1 regulation of Il6 gene expression by murine macrophages: a pivotal role for GM-CSFR Evans
The Jackson Laboratory, Bar Harbor, Maine 04609, USA
J Leukoc Biol 64:810-6. 1998.... - Development and progression of psoriasiform dermatitis and systemic lesions in the flaky skin (fsn) mouse mutantJ P Sundberg
Jackson Laboratory, Bar Harbor, ME 04609 1500, USA
Pathobiology 65:271-86. 1997..This spontaneous mouse mutation provides a useful model for modulating neovascularization and keratinocyte hyperproliferation, especially since the cutaneous changes resemble some forms of psoriasis in humans... - Human acute leukemia cells injected in NOD/LtSz-scid/IL-2Rgamma null mice generate a faster and more efficient disease compared to other NOD/scid-related strainsAlice Agliano
Division of Hematology Oncology, Department of Medicine, European Institute of Oncology, Milan, Italy
Int J Cancer 123:2222-7. 2008..These models will be instrumental to studies on leukemia-initiating stem cells, leukemia biology, preclinical treatment studies, and to obtain patient-specific preclinical models to design and investigate patient-tailored therapies... - Humanized NOD/LtSz-scid IL2 receptor common gamma chain knockout mice in diabetes researchLeonard D Shultz
Division of Diabetes, Department of Medicine, 373 Plantation Street, Biotech 2, Suite 218, Worcester, MA 01605, USA
Ann N Y Acad Sci 1103:77-89. 2007..Overall, development of these new generations of humanized mice should facilitate in vivo studies of the human immune system as well as permit the investigation of the pathogenesis and effector phases of human T1D... - Targeting gastrin-releasing peptide receptors on small cell lung cancer cells with a bispecific molecule that activates polyclonal T lymphocytesJiehua Zhou
Division of Blood and Marrow Transplantation, Department of Medicine and Moores University of California at San Diego Cancer Center, University of California San Diego, La Jolla, California, USA
Clin Cancer Res 12:2224-31. 2006..Clinical trials of this bispecific molecule through adoptive transfer of ex vivo activated T cells in GRP receptor-positive tumors, such as SCLC, are warranted... - The leukotriene B4 receptor (BLT1) is required for effector CD8+ T cell-mediated, mast cell-dependent airway hyperresponsivenessChristian Taube
Division of Cell Biology, Department of Pediatrics, National Jewish Medical and Research Center, Denver, CO 80206, USA
J Immunol 176:3157-64. 2006..Together, these data define the important role for mast cells and the LTB4-BLT1 pathway in the development of CD8+ T cell-mediated allergic responses in the lung... - Disruption of the Jnk2 (Mapk9) gene reduces destructive insulitis and diabetes in a mouse model of type I diabetesAnja Jaeschke
Howard Hughes Medical Institute and Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, MA 01605, USA
Proc Natl Acad Sci U S A 102:6931-5. 2005..We conclude that JNK protein kinases may have important roles in diabetes, including functions of JNK1 in type 2 diabetes and JNK2 in type 1 diabetes... - Autoimmune diabetes and resistance to xenograft transplantation tolerance in NOD miceEthel J Gordon
University of Massachusetts Medical School, Diabetes Division, Department of Medicine, 373 Plantation St, Biotech 2, Suite 218, Worcester, MA 01605, USA
Diabetes 54:107-15. 2005..We conclude that the resistance of NOD mice to xenograft tolerance induction involves some mechanisms that also participate in the expression of autoimmunity and other mechanisms that are distinct... - Appearance of human plasma cells following differentiation of human B cells in NOD/SCID mouse spleenKentaro Kikuchi
Division of Rheumatology, Allergy and Clinical Immunology, University of California at Davis School of Medicine, TB 192, Davis, CA 95616, USA
Clin Dev Immunol 10:197-202. 2003..The model will be useful for studying the differentiation of human B cells and generation of plasma cells... - Distinct osteoclast precursors in the bone marrow and extramedullary organs characterized by responsiveness to Toll-like receptor ligands and TNF-alphaShin ichi Hayashi
Department of Molecular and Cellular Biology, School of Life Science, Faculty of Medicine, Institute of Regenerative Medicine and Biofunction, Graduate School of Medical Science, Tottori University, Tottori, Japan
J Immunol 171:5130-9. 2003.... - Human cord blood- and bone marrow-derived CD34+ cells regenerate gastrointestinal epithelial cellsFumihiko Ishikawa
Department of Medicine and Biosystemic Science, Kyushu University Graduate School of Medicine, Fukuoka, Japan
FASEB J 18:1958-60. 2004..On the basis of these findings, it is concluded that purified human cord blood and bone marrow CD34+ progenitor cells can generate gastrointestinal epithelial cells across allogeneic and xenogeneic histocompatibility barriers... - Humanized mice as a preclinical tool for infectious disease and biomedical researchLeonard D Shultz
The Jackson Laboratory, Bar Harbor, Maine, USA
Ann N Y Acad Sci 1245:50-4. 2011..Immunodeficient mice bearing an IL2rγ(null) mutation permit engraftment of a functional human immune system and study of human-specific infectious agents that was not previously possible... - Initiation of autoimmune diabetes in NOD/Lt mice is MHC class I-dependentD V Serreze
The Jackson Laboratory, Bar Harbor, ME 04609, USA
J Immunol 158:3978-86. 1997.... - Brugian infections in the peritoneal cavities of laboratory mice: kinetics of infection and cellular responsesT V Rajan
The University of Connecticut Health Center, 263 Farmington Avenue, 06030 3105, USA
Exp Parasitol 100:235-47. 2002..These granulomas may represent an important mechanism by which worms are eliminated... - Inflammation and autoimmunity caused by a SHP1 mutation depend on IL-1, MyD88, and a microbial triggerBen A Croker
Department of Genetics, The Scripps Research Institute, 10550 N Torrey Pines Road, La Jolla, CA 92037, USA
Proc Natl Acad Sci U S A 105:15028-33. 2008..The SHP1-deficient phenotype is driven by microbes, which activate TLR signaling pathways to elicit IL-1 production. IL-1 signaling via MyD88 elicits inflammatory disease... - Bombesin/gastrin-releasing peptide receptor: a potential target for antibody-mediated therapy of small cell lung cancerJiehua Zhou
Division of Blood and Marrow Transplantation, Department of Medicine, University of California San Diego, La Jolla, California 92093-0960, USA
Clin Cancer Res 9:4953-60. 2003..CONCLUSIONS: Combined chemotherapy and immunotherapy targeting BN/GRP-R with a BsMol significantly enhances targeted SCLC cell killing... - Mouse neutrophils lacking lamin B-receptor expression exhibit aberrant development and lack critical functional responsesPeter Gaines
University of Massachusetts Lowell, Department of Biological Sciences, Lowell, MA 01854, USA peter_uml edu
Exp Hematol 36:965-76. 2008..In this study, we have investigated roles for LBR in mediating neutrophil development and activation of multiple neutrophil functions, including chemotaxis and the respiratory burst... - Purified human hematopoietic stem cells contribute to the generation of cardiomyocytes through cell fusionFumihiko Ishikawa
Department of Medicine and Biosystemic Science, Kyushu University Graduate School of Medical Sciences, 3 1 1 Maidashi, Higashi ku, Fukuoka 812 8582, Japan
FASEB J 20:950-2. 2006.... - A new murine model of humoral immuno-deficiency specifically affects class switching to T-independent antigensIgor I Kuzin
Department of Medicine, University of Rochester School of Medicine and Dentistry, Rochester 14625, USA
Eur J Immunol 34:1807-16. 2004..This new mouse model will be of interest for the understanding of mechanisms involved in TI immune responses and may provide new insights into the molecular basis of human Ig deficiencies... - Islet allograft survival induced by costimulation blockade in NOD mice is controlled by allelic variants of Idd3Todd Pearson
The University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
Diabetes 53:1972-8. 2004.... - TGF-beta1 inhibits T-bet induction by IFN-gamma in murine CD4+ T cells through the protein tyrosine phosphatase Src homology region 2 domain-containing phosphatase-1Il Kyoo Park
Department of Pathology, Dartmouth Medical School, Lebanon, NH 03756, USA
J Immunol 175:5666-74. 2005..Together, these data show that TGF-beta1 suppresses IFN-gamma signaling and transcriptional responses in CD4+ T cells through the PTP Shp-1... - Type 1 IFN mediates cross-talk between innate and adaptive immunity that abrogates transplantation toleranceThomas B Thornley
Department of Medicine, Division of Diabetes, University of Massachusetts Medical School, Worcester, MA 01655, USA
J Immunol 179:6620-9. 2007..Blocking of type 1 IFN-dependent pathways in patients may improve allograft survival in the presence of exogenous TLR ligands... - Humanized mice: are we there yet?Francesca Macchiarini
Division of Allergy, Immunology, and Transplantation, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892, USA
J Exp Med 202:1307-11. 2005.... - Lipopolysaccharide-induced osteoclastogenesis in Src homology 2-domain phosphatase-1-deficient viable motheaten miceShin ichi Hayashi
Division of Immunology, Department of Molecular and Cellular Biology, School of Life Science, Faculty of Medicine, Tottori University, 86 Nishi Machi, Yonago, Tottori 683 8503, Japan
Endocrinology 145:2721-9. 2004..These results indicate that a defect of Src homology 2-domain phosphatase-1 function not only accelerates physiological osteoclast development by RANKL/RANK, but also acquires a novel pathway for osteoclastogenesis by LPS... - Humanized mice for immune system investigation: progress, promise and challengesLeonard D Shultz
The Jackson Laboratory, 600 Main Street, Bar Harbor, Maine 04609, USA
Nat Rev Immunol 12:786-98. 2012..In this Review, we discuss recent advances in the development and utilization of humanized mice, the lessons learnt, the remaining challenges and the promise of using humanized mice for the in vivo study of human immunology... - Enhanced humoral and HLA-A2-restricted dengue virus-specific T-cell responses in humanized BLT NSG miceSmita Jaiswal
Division of Infectious Diseases and Immunology, University of Massachusetts Medical School, Worcester, MA, USA
Immunology 136:334-43. 2012..The BLT-NSG mice will allow assessment of human immune responses to DENV vaccines and the effects of previous immunity on subsequent DENV infections... - A deficiency of ceramide biosynthesis causes cerebellar purkinje cell neurodegeneration and lipofuscin accumulationLihong Zhao
The Jackson Laboratory, Bar Harbor, Maine, United States of America
PLoS Genet 7:e1002063. 2011.... - A null mutation in inositol polyphosphate 4-phosphatase type I causes selective neuronal loss in weeble mutant miceA Nystuen
The Jackson Laboratory, 600 Main Street, Bar Harbor, ME 04609, USA
Neuron 32:203-12. 2001..Although other mutations in phosphoinositide enzymes are associated with synaptic defects without neuronal loss, weeble shows that Inpp4a is critical for the survival of a subset of neurons during postnatal development in mice... - Mapping of the flaky skin (fsn) mutation on distal mouse chromosome 17S C Pelsue
Jackson Laboratory, Bar Harbor, Maine 04609-1500, USA
Mamm Genome 6:758. 1995 - Lymphadenopathy, elevated serum IgE levels, autoimmunity, and mast cell accumulation in flaky skin mutant miceS C Pelsue
The Jackson Laboratory, Bar Harbor, ME 04609, USA
Eur J Immunol 28:1379-88. 1998..These marked immunological abnormalities suggest that the fsn locus encodes a major immunoregulatory molecule important in multiple immune and hematopoietic functions... - In vivo distribution of human adipose-derived mesenchymal stem cells in novel xenotransplantation modelsTodd E Meyerrose
Washington University School of Medicine, Division of Oncology, Hematopoietic Development and Malignancy Section, St Louis, Missouri 63110, USA
Stem Cells 25:220-7. 2007..AMSC are easily obtained and highly amenable to current transduction protocols for retroviral transduction, making them an excellent avenue for cell-based therapies that involve a wide range of end tissue targets... - SHP-1 regulates STAT6 phosphorylation and IL-4-mediated function in a cell type-specific mannerZan Huang
The Department of Cell Biology, Loyola University Chicago, Stritch School of Medicine, Maywood, IL 60153, USA
Cytokine 29:118-24. 2005..Thus, our data suggest that SHP-1 may regulate IL-4-induced STAT6 phosphorylation and IL-4-mediated functions in a cell type-specific manner... - The developmental program of human dendritic cells is operated independently of conventional myeloid and lymphoid pathwaysFumihiko Ishikawa
Research Unit for Human Disease Model, Rikagaku Kenkyusho RIKEN Research Center for Allergy and Immunology, Yokohama, Japan
Blood 110:3591-660. 2007..We propose that human DCs use unique and flexible developmental programs that cannot be categorized into the conventional myeloid or lymphoid pathway... - Mutations in the gene encoding the lamin B receptor produce an altered nuclear morphology in granulocytes (Pelger-Huët anomaly)Katrin Hoffmann
Gene Mapping Center, Max Delbrück Center for Molecular Medicine and Franz Volhard Clinic, HELIOS Klinikum, Charite, Humboldt University, Berlin, Germany
Nat Genet 31:410-4. 2002..Our findings have implications for understanding nuclear envelope-heterochromatin interactions, the pathogenesis of Pelger-like conditions in leukemia, infection and toxic drug reactions, and the evolution of neutrophil nuclear shape... - Curly bare (cub), a new mouse mutation on chromosome 11 causing skin and hair abnormalities, and a modifier gene (mcub) on chromosome 5Kenneth R Johnson
The Jackson Laboratory, 600 Main Street, Bar Harbor, ME 04609, USA
Genomics 81:6-14. 2003..The similarity of the wavy coat phenotype to those of Tgfa and Egfr mutations and the map positions of cub and mcub suggest candidate genes that interact in the EGF receptor signal transduction pathway... - Enhanced human CD4+ T cell engraftment in beta2-microglobulin-deficient NOD-scid miceS W Christianson
The Jackson Laboratory, Bar Harbor, ME 04609, USA
J Immunol 158:3578-86. 1997.... - Mutations at the murine motheaten locus are within the hematopoietic cell protein-tyrosine phosphatase (Hcph) geneL D Shultz
Jackson Laboratory, Bar Harbor, Maine 04609
Cell 73:1445-54. 1993..These findings provide the first available animal models for a specific protein-tyrosine phosphatase deficiency, thus facilitating determination of the precise role of this signaling molecule in hematopoiesis... - Constant rate of steady-state self-antigen trafficking from skin to regional lymph nodesMiya Yoshino
Division of Immunology, Department of Molecular and Cellular Biology, School of Life Science, Faculty of Medicine, Tottori University, Yonago, 683 8503, Japan
Int Immunol 18:1541-8. 2006.... - Age-related alterations in the lymphohematopoietic and B-lineage precursor populations in NZB miceZhe-Xiong Lian
Division of Rheumatology/Allergy and Clinical Immunology, University of California at Davis, Davis, California 95616, USA
Stem Cells 20:293-300. 2002.... - Primed peritoneal B lymphocytes are sufficient to transfer protection against Brugia pahangi infection in miceNatalia Paciorkowski
Department of Pathology, University of Connecticut Health Center, Farmington, Connecticut 06030-3105, USA
Infect Immun 71:1370-8. 2003..pahangi infection. The data demonstrate a critical role of B lymphocytes in antifilarial immunity in naïve mice and in the memory response in primed mice... - Treatment and transfer of emphysema by a new bone marrow transplantation method from normal mice to Tsk mice and vice versaYasushi Adachi
First Department of Pathology, Kansai Medical University, Moriguchi City, Osaka, Japan, 570-0023
Stem Cells 24:2071-7. 2006..Six months after IBM-BMT, the [Tsk-->C3H] mice showed emphysema. These results strongly suggest that emphysema in Tsk mice originates from defects of stem cells in the bone marrow... - Increased frequency of pre-pro B cells in the bone marrow of New Zealand Black (NZB) mice: implications for a developmental block in B cell differentiationZhe-Xiong Lian
Division of Rheumatology, Allergy and Clinical Immunology, University of California at Davis School of Medicine, 95616, USA
Dev Immunol 9:35-45. 2002..The decreased frequency of precursor B cells in the Pre-Pro B cell population occurs at the most primitive stage of B cell differentiation... - Defective repair of radiation-induced chromosomal damage in scid/scid miceJ E Disney
Jackson Laboratory, Bar Harbor, ME 04609
Cytogenet Cell Genet 59:39-44. 1992..The scid mutation may provide important clues for understanding the relationship between mitotic recombination and DNA repair in higher eukaryotic cells... - Gene for ovarian granulosa cell tumor susceptibility, Gct, in SWXJ recombinant inbred strains of mice revealed by dehydroepiandrosteroneW G Beamer
Jackson Laboratory, Bar Harbor, Maine 04609
Cancer Res 48:5092-5. 1988..These data support a heritable basis for GC tumorigenesis in the SWR model involving a small number of genes... - Granulosa cell tumorigenesis in genetically hypogonadal-immunodeficient mice grafted with ovaries from tumor-susceptible donorsW G Beamer
Jackson Laboratory, Bar Harbor, Maine 04609
Cancer Res 53:3741-6. 1993..We hypothesize that ovarian androgens synthesized in response to normal gonadotropin stimulation initiate spontaneous tumorigenesis in the genetically susceptible ovary... - Genetic mapping of the IL-12 alpha chain gene (Il12a) on mouse chromosome 3P A Schweitzer
The Jackson Laboratory, Bar Harbor, Maine 04609, USA
Mamm Genome 7:394-5. 1996 - The interleukin-12 beta subunit (p40) maps to mouse chromosome 11N Noben-Trauth
The Jackson Laboratory, 600 Main Street, Bar Harbor, Maine 04609, USA
Mamm Genome 7:392. 1996 - The inner nuclear membrane protein lamin B receptor forms distinct microdomains and links epigenetically marked chromatin to the nuclear envelopeDimitra Makatsori
Laboratory of Biology, The University of Ioannina, School of Medicine, 45 110 Ioannina, Greece
J Biol Chem 279:25567-73. 2004..The organization of these membrane assemblies is affected significantly in heterozygous ic (ichthyosis) mutants, resulting in a variety of structural abnormalities and nuclear defects... - Chemotherapy-resistant human AML stem cells home to and engraft within the bone-marrow endosteal regionFumihiko Ishikawa
Research Unit for Human Disease Models, RIKEN Research Center for Allergy and Immunology, 1 7 22 Suehiro cho Tsurumi ku, Yokohama 230 0045, Japan
Nat Biotechnol 25:1315-21. 2007..These results indicate the potential utility of this AML xenograft model in the development of novel therapeutic strategies targeted at LS cells...