S Shete

Summary

Affiliation: The University of Texas
Country: USA

Publications

  1. pmc A powerful hybrid approach to select top single-nucleotide polymorphisms for genome-wide association study
    Jian Wang
    Department of Epidemiology, The University of Texas M D Anderson Cancer Center, Houston, 77030, USA
    BMC Genet 12:3. 2011
  2. ncbi request reprint Calculation of exact p-values when SNPs are tested using multiple genetic models
    Rajesh Talluri
    Department of Biostatistics, The University of Texas MD Anderson Cancer Center, Houston, TX, USA
    BMC Genet 15:75. 2014
  3. pmc A linkage disequilibrium-based approach to selecting disease-associated rare variants
    Rajesh Talluri
    Department of Biostatistics, The University of Texas MD Anderson Cancer Center, Houston, Texas, United States of America
    PLoS ONE 8:e69226. 2013
  4. pmc Method for evaluating multiple mediators: mediating effects of smoking and COPD on the association between the CHRNA5-A3 variant and lung cancer risk
    Jian Wang
    Department of Biostatistics, The University of Texas MD Anderson Cancer Center, Houston, Texas, United States of America
    PLoS ONE 7:e47705. 2012
  5. pmc Testing Hardy-Weinberg proportions in a frequency-matched case-control genetic association study
    Jian Wang
    Department of Epidemiology, The University of Texas MD Anderson Cancer Center, Houston, Texas, United States of America
    PLoS ONE 6:e27642. 2011
  6. pmc The moderating role of parental smoking on their children's attitudes toward smoking among a predominantly minority sample: a cross-sectional analysis
    Anna V Wilkinson
    Department of Epidemiology, Unit 1340, The University of Texas M, d, Anderson Cancer Center, PO Box 301439, Houston, TX 77230, USA
    Subst Abuse Treat Prev Policy 3:18. 2008
  7. pmc The null distribution of stochastic search gene suggestion: a Bayesian approach to gene mapping
    Michael D Swartz
    Department of Epidemiology, University of Texas M, Anderson Cancer Center, Box 301439, Houston, Texas 77230 1439, USA
    BMC Proc 1:S113. 2007
  8. pmc Seeking gene relationships in gene expression data using support vector machine regression
    Robert Yu
    Department of Epidemiology, Unit 1340, The University of Texas M, Anderson Cancer Center, 1155 Hermann Pressler Boulevard, Houston, Texas 77030, USA
    BMC Proc 1:S51. 2007
  9. pmc Comparison of genome-wide single-nucleotide polymorphism linkage analyses in Caucasian and Hispanic NARAC families
    Wei V Chen
    Department of Epidemiology, Anderson Cancer Center, Houston, Texas 77030, USA
    BMC Proc 1:S97. 2007
  10. pmc Joint linkage and imprinting analyses of GAW15 rheumatoid arthritis and gene expression data
    Xiaojun Zhou
    Department of Epidemiology, Unit 1340, The University of Texas M, Anderson Cancer Center, 1155 Hermann Pressler Boulevard, Houston, TX, 77030, USA
    BMC Proc 1:S53. 2007

Research Grants

Collaborators

Detail Information

Publications88

  1. pmc A powerful hybrid approach to select top single-nucleotide polymorphisms for genome-wide association study
    Jian Wang
    Department of Epidemiology, The University of Texas M D Anderson Cancer Center, Houston, 77030, USA
    BMC Genet 12:3. 2011
    ..We proposed a hybrid approach for selecting candidate SNPs from the discovery stage of GWA study, based on both p values and ORs, and conducted a simulation study to demonstrate the performance of our approach...
  2. ncbi request reprint Calculation of exact p-values when SNPs are tested using multiple genetic models
    Rajesh Talluri
    Department of Biostatistics, The University of Texas MD Anderson Cancer Center, Houston, TX, USA
    BMC Genet 15:75. 2014
    ..g., asymptotic multivariate normality or independence among the tests)...
  3. pmc A linkage disequilibrium-based approach to selecting disease-associated rare variants
    Rajesh Talluri
    Department of Biostatistics, The University of Texas MD Anderson Cancer Center, Houston, Texas, United States of America
    PLoS ONE 8:e69226. 2013
    ..The power comparisons after controlling the type 1 error show that the proposed linkage disequilibrium-based subset selection approach is an attractive alternative method for subset selection of rare variants. ..
  4. pmc Method for evaluating multiple mediators: mediating effects of smoking and COPD on the association between the CHRNA5-A3 variant and lung cancer risk
    Jian Wang
    Department of Biostatistics, The University of Texas MD Anderson Cancer Center, Houston, Texas, United States of America
    PLoS ONE 7:e47705. 2012
    ..3% through smoking alone, 30.2% through COPD alone, and 20.6% through the path including both smoking and COPD, and the total genetic variant-lung cancer association explained by the two mediators was 69.1%...
  5. pmc Testing Hardy-Weinberg proportions in a frequency-matched case-control genetic association study
    Jian Wang
    Department of Epidemiology, The University of Texas MD Anderson Cancer Center, Houston, Texas, United States of America
    PLoS ONE 6:e27642. 2011
    ....
  6. pmc The moderating role of parental smoking on their children's attitudes toward smoking among a predominantly minority sample: a cross-sectional analysis
    Anna V Wilkinson
    Department of Epidemiology, Unit 1340, The University of Texas M, d, Anderson Cancer Center, PO Box 301439, Houston, TX 77230, USA
    Subst Abuse Treat Prev Policy 3:18. 2008
    ..The goals of the current analysis were to examine these two potential mechanisms...
  7. pmc The null distribution of stochastic search gene suggestion: a Bayesian approach to gene mapping
    Michael D Swartz
    Department of Epidemiology, University of Texas M, Anderson Cancer Center, Box 301439, Houston, Texas 77230 1439, USA
    BMC Proc 1:S113. 2007
    ..In order to assess the null distribution we used the simulated data with the "answers" known...
  8. pmc Seeking gene relationships in gene expression data using support vector machine regression
    Robert Yu
    Department of Epidemiology, Unit 1340, The University of Texas M, Anderson Cancer Center, 1155 Hermann Pressler Boulevard, Houston, Texas 77030, USA
    BMC Proc 1:S51. 2007
    ..The model was subsequently used to search for and capture similarly related genes. SVMR shows promising capability in modeling and seeking gene relationships through expression data...
  9. pmc Comparison of genome-wide single-nucleotide polymorphism linkage analyses in Caucasian and Hispanic NARAC families
    Wei V Chen
    Department of Epidemiology, Anderson Cancer Center, Houston, Texas 77030, USA
    BMC Proc 1:S97. 2007
    ..A larger sample size of the Hispanic group is needed to identify linkage regions...
  10. pmc Joint linkage and imprinting analyses of GAW15 rheumatoid arthritis and gene expression data
    Xiaojun Zhou
    Department of Epidemiology, Unit 1340, The University of Texas M, Anderson Cancer Center, 1155 Hermann Pressler Boulevard, Houston, TX, 77030, USA
    BMC Proc 1:S53. 2007
    ..03 for imprinting, but increase in the LOD score did not meet the required threshold to reliably identify imprinting as the correct mode of inheritance in genome-wide linkage scans...
  11. pmc Examining the effect of linkage disequilibrium on multipoint linkage analysis
    Qiqing Huang
    Department of Epidemiology, University of Texas M D Anderson Cancer Center, Houston, Texas, USA
    BMC Genet 6:S83. 2005
    ..Bias can be eliminated with parental data and can be reduced when additional markers not in LD are included in the analyses...
  12. pmc Analysis of genes for alcoholism using two-disease-locus models
    Chih Chieh Wu
    Department of Epidemiology, The University of Texas M D Anderson Cancer Center, Houston, Texas, USA
    BMC Genet 6:S149. 2005
    ..We investigated the genetic linkage, pattern of disease inheritance, and pair-wise genetic epistasis of these loci using the TLINKAGE program for two-disease-locus analysis...
  13. pmc Analysis of alcoholism data using support vector machines
    Robert Yu
    Department of Epidemiology, Unit 1340, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    BMC Genet 6:S136. 2005
    ..g., 96% in the fourfold cross-validations. However, owing to the limited sample data, we were not able to test the predictions of the classifiers in the new sample data...
  14. pmc Effects of population structure on genetic association studies
    Hongyan Xu
    Department of Epidemiology, Unit 1340, University of Texas M D Anderson Cancer Center, 1155 Hermann Pressler Boulevard, Houston, TX 77030, USA
    BMC Genet 6:S109. 2005
    ..The approach presented in this paper could be used to select the appropriate number of markers for use in the genomic control method of correcting population structure...
  15. ncbi request reprint A note on the optimal measure of allelic association
    S Shete
    Department of Epidemiology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Ann Hum Genet 67:189-91. 2003
    ..In particular, we have shown that this measure has intuitive appeal and the estimator for this measure has several statistically optimal properties such as consistency, asymptotic unbiasedness and asymptotic efficiency...
  16. pmc Genetic imprinting analysis for alcoholism genes using variance components approach
    Sanjay Shete
    Department of Epidemiology, Unit 1340, University of Texas M D Anderson Cancer Center, 1155 Hermann Pressler Boulevard, Houston, TX 77030, USA
    BMC Genet 6:S161. 2005
    ..Our results suggest that allowing for the possibility of imprinting can increase the power to detect linkage for localizing genes for alcoholism...
  17. ncbi request reprint Parametric approach to genomic imprinting analysis with applications to Angelman's syndrome
    Sanjay Shete
    Department of Epidemiology, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Hum Hered 59:26-33. 2005
    ..These analyses showed that the proposed approach is very powerful for detecting imprinted genes in large pedigrees...
  18. ncbi request reprint Mixed-effects logistic approach for association following linkage scan for complex disorders
    H Xu
    Department of Epidemiology, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Ann Hum Genet 71:230-7. 2007
    ..Our method can be further extended to accommodate more complex pedigree structures...
  19. ncbi request reprint TLINKAGE-IMPRINT: a model-based approach to performing two-locus genetic imprinting analysis
    Sanjay Shete
    Department of Epidemiology, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Hum Hered 62:145-56. 2006
    ..2000] to obtain a method for qualitative trait linkage analyses that explicitly models imprinting and can be applied to large pedigrees...
  20. pmc Genome-wide high-density SNP linkage search for glioma susceptibility loci: results from the Gliogene Consortium
    Sanjay Shete
    Department of Epidemiology, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA
    Cancer Res 71:7568-75. 2011
    ..81 (P = 0.00001). The genomic regions we have implicated in this study may offer novel insights into glioma susceptibility, focusing future work to identify genes that cause familial glioma...
  21. pmc Individual-specific liability groups in genetic linkage, with applications to kindreds with Li-Fraumeni syndrome
    Sanjay Shete
    Department of Epidemiology, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Am J Hum Genet 70:813-7. 2002
    ..Application of our method to these families yielded significantly higher LOD scores and more-accurate recombination fractions than did analysis that did not account for individual-specific covariate information...
  22. ncbi request reprint Adding further power to the Haseman and Elston method for detecting linkage in larger sibships: weighting sums and differences
    Sanjay Shete
    Department of Epidemiology, University of Texas, M D Anderson Cancer Center, Houston, Tex 77030, USA
    Hum Hered 55:79-85. 2003
    ..Control of the type I error probabilities for sibships of any size can be improved by using a generalized estimating equation approach and the robust sandwich estimate of the variance, or a Monte-Carlo permutation test...
  23. ncbi request reprint Effect of winsorization on power and type 1 error of variance components and related methods of QTL detection
    Sanjay Shete
    Department of Epidemiology, University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
    Behav Genet 34:153-9. 2004
    ..A robust version of the LRT that adjusts for sample kurtosis showed the best power for nonnormal data. Finally, phenotype winsorization of nonnormal data reduces the bias in estimation of the major gene variance component...
  24. ncbi request reprint Uniformly minimum variance unbiased estimation of gene diversity
    Sanjay Shete
    Department of Epidemiology, Box 189, University of Texas, M D Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX 77030, USA
    J Hered 94:421-4. 2003
    ..In accordance with the simulation results, I found that the uniformly minimum variance estimator developed in this report is more accurate for estimation of gene diversity than the maximum likelihood estimator...
  25. pmc Genomic imprinting and linkage test for quantitative-trait Loci in extended pedigrees
    Sanjay Shete
    Department of Epidemiology, The University of Texas M D Anderson Cancer Center, Houston, TX, 77030, USA
    Am J Hum Genet 73:933-8. 2003
    ..We found that the proposed method is more powerful and uses extended-pedigree information most efficiently...
  26. pmc Testing for genetic linkage in families by a variance-components approach in the presence of genomic imprinting
    Sanjay Shete
    Department of Epidemiology, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Am J Hum Genet 70:751-7. 2002
    ..Optimal strategies for a genome scan of potentially imprinted traits are discussed...
  27. pmc A test for genetic association that incorporates information about deviation from Hardy-Weinberg proportions in cases
    Jian Wang
    Department of Epidemiology, M D Anderson Cancer Center, University of Texas, Houston, TX 77030, USA
    Am J Hum Genet 83:53-63. 2008
    ..Results from simulation studies and real-disease studies demonstrate that the proposed approach is more powerful than the traditional logistic-regression model. The type I error probabilities of our approach were also well controlled...
  28. ncbi request reprint Variance components analysis for genetic linkage of time to onset for disease
    C I Amos
    Department of Epidemiology, University of Texas M.D. Anderson Cancer Center, 1515 Holcombe Blvd, Box 189, Houston, TX 77030, USA
    Genet Epidemiol 21:S768-73. 2001
    ....
  29. ncbi request reprint Polymorphisms and haplotypes of the NBS1 gene are associated with risk of sporadic breast cancer in non-Hispanic white women <or=55 years
    Jiachun Lu
    Department of Epidemiology, The University of Texas M D Anderson Cancer Center Houston, TX 77030, USA
    Carcinogenesis 27:2209-16. 2006
    ..006). These findings suggest that NBS1 polymorphisms and haplotypes may contribute to the etiology of sporadic breast cancer in young non-Hispanic white women. Large studies are warranted to confirm these findings...
  30. ncbi request reprint Haplotypes of two variants in p16 (CDKN2/MTS-1/INK4a) exon 3 and risk of squamous cell carcinoma of the head and neck: a case-control study
    Yuxin Zheng
    Department of Epidemiology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Cancer Epidemiol Biomarkers Prev 11:640-5. 2002
    ..We conclude that these polymorphic p16 genotypes or haplotypes may not play a major role in the etiology of SCCHN, if any. However, our limited sample size and power call for larger studies for additional verification of our findings...
  31. ncbi request reprint A novel approach to detect parent-of-origin effects from pedigree data with application to Beckwith-Wiedemann syndrome
    Sanjay Shete
    Department of Epidemiology, The University of Texas M D Anderson Cancer Center, Houston, TX, USA
    Ann Hum Genet 71:804-14. 2007
    ....
  32. ncbi request reprint Adaptations of linkage and association methods for the study of asthma, a complex trait
    C H Bosken
    Department of Epidemiology, M. D. Anderson Cancer Center, University of Texas, Houston, Texas, USA
    Genet Epidemiol 21:S89-96. 2001
    ..In addition, haplotype analysis may help to identify specific genetic effects...
  33. pmc Myozenin 2 is a novel gene for human hypertrophic cardiomyopathy
    Adriana Osio
    Center for Cardiovascular Genetic Research, The Brown Foundation Institute of Molecular Medicine, University of Texas Health Sciences Center, Houston, TX 77030, USA
    Circ Res 100:766-8. 2007
    ..It was absent in 2 normal family members and 517 controls. Both mutations affect highly conserved amino acids. We conclude MYOZ2 is a novel causal gene for human HCM...
  34. pmc Major histocompatibility complex (MHC) class II alleles, haplotypes and epitopes which confer susceptibility or protection in systemic sclerosis: analyses in 1300 Caucasian, African-American and Hispanic cases and 1000 controls
    Frank C Arnett
    Division of Rheumatology, Department of Internal Medicine, The University of Texas Health Science Center at Houston UTHSC H, 6431 Fannin Street, MSB 5 270, Houston, TX 77030, USA
    Ann Rheum Dis 69:822-7. 2010
    ....
  35. pmc Using both cases and controls for testing hardy-weinberg proportions in a genetic association study
    Jian Wang
    Department of Epidemiology, The University of Texas M D Anderson Cancer Center, Houston, TX, USA
    Hum Hered 69:212-8. 2010
    ..In this paper, we showed the inappropriateness of the HWP test in controls and proposed a mixture HWP (mHWP) exact test using a mixture sample that mimics the general population...
  36. ncbi request reprint Familial thoracic aortic aneurysms and dissections: three families with early-onset ascending and descending aortic dissections in women
    Van Tran-Fadulu
    Department of Internal Medicine, Division of Medical Genetics, The University of Texas Medical School at Houston, Houston, Texas 77030, USA
    Am J Med Genet A 140:1196-202. 2006
    ..Thus, a novel unidentified loci may be responsible for the phenotype in these three families...
  37. ncbi request reprint Methylenetetrahydrofolate reductase polymorphisms and risk of squamous cell carcinoma of the head and neck: a case-control analysis
    Ana S Neumann
    Department of Epidemiology, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Int J Cancer 115:131-6. 2005
    ..Future studies should incorporate detailed data on alcohol consumption, dietary folate intake and related serologic measurements...
  38. ncbi request reprint Comparison of haplotype inference methods using genotypic data from unrelated individuals
    Hongyan Xu
    Department of Epidemiology, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Hum Hered 58:63-8. 2004
    ..The accuracy, efficiency, and computational time of these methods have been under intense scrutiny. In this report, our aim was to evaluate haplotype inference methods for genotypic data from unrelated individuals...
  39. ncbi request reprint Modulation of repair of ultraviolet damage in the host-cell reactivation assay by polymorphic XPC and XPD/ERCC2 genotypes
    Yawei Qiao
    Department of Epidemiology, The University of Texas M D Anderson Cancer Center, Houston, 1515 Holcombe Boulevard, TX 77030, USA
    Carcinogenesis 23:295-9. 2002
    ..We concluded that these NER polymorphisms may modulate DRC and may be useful biomarkers for identifying individuals at risk of developing cancer...
  40. ncbi request reprint Modulation of nucleotide excision repair capacity by XPD polymorphisms in lung cancer patients
    M R Spitz
    Department of Epidemiology, The University of Texas M D Anderson Cancer Center, Houston 77030, USA
    Cancer Res 61:1354-7. 2001
    ..These results suggest that the two XPD polymorphisms have a modulating effect on DRC, especially in the cases...
  41. ncbi request reprint Effect of Box-Cox transformation on power of Haseman-Elston and maximum-likelihood variance components tests to detect quantitative trait Loci
    C J Etzel
    Department of Epidemiology, University of Texas, M D Anderson Cancer Center, Houston, Tex 77030, USA
    Hum Hered 55:108-16. 2003
    ..We repeated the same simulations using a larger sample size (200 sib pairs) and found similar results...
  42. ncbi request reprint From genotype to phenotype: correlating XRCC1 polymorphisms with mutagen sensitivity
    Yunfei Wang
    Department of Epidemiology, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    DNA Repair (Amst) 2:901-8. 2003
    ..To our knowledge, this is the largest study conducted evaluating the functional relevance of these polymorphisms...
  43. ncbi request reprint Complex segregation analysis reveals a multigene model for lung cancer
    Hongyan Xu
    Department of Epidemiology, Unit 189, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
    Hum Genet 116:121-7. 2005
    ..The results provide evidence that multiple genetic factors contribute to lung cancer and may act as a guide in further studies to localize susceptibility genes in lung cancer...
  44. ncbi request reprint GLIOGENE an International Consortium to Understand Familial Glioma
    Beatrice Malmer
    Department of Epidemiology, The University of Texas M D Anderson Cancer Center, Unit 1340, P O Box 301439, Houston, TX 77230 1439, USA
    Cancer Epidemiol Biomarkers Prev 16:1730-4. 2007
    ..Here, we review the rationale for studying familial glioma and our proposed strategy for the GLIOGENE study...
  45. pmc Mediating effects of smoking and chronic obstructive pulmonary disease on the relation between the CHRNA5-A3 genetic locus and lung cancer risk
    Jian Wang
    Department of Epidemiology, The University of Texas M D Anderson Cancer Center, Houston, Texas
    Cancer 116:3458-62. 2010
    ..However, it has not been established whether the association between genetic variants and lung cancer risk is a direct one or one mediated by nicotine dependence...
  46. pmc Ignoring linkage disequilibrium among tightly linked markers induces false-positive evidence of linkage for affected sib pair analysis
    Qiqing Huang
    Department of Epidemiology, University of Texas M D Anderson Cancer Center, Houston, TX 77030 4009, USA
    Am J Hum Genet 75:1106-12. 2004
    ..Bias can be eliminated by inclusion of parental genotype data and can be reduced when additional unaffected siblings are included in the analysis...
  47. pmc A genome-wide association study identifies a locus on chromosome 14q21 as a predictor of leukocyte telomere length and as a marker of susceptibility for bladder cancer
    Jian Gu
    Department of Epidemiology, Unit 1340, The University of Texas MD Anderson Cancer Center, 1155 Pressler Blvd, Houston, TX 77030, USA
    Cancer Prev Res (Phila) 4:514-21. 2011
    ..In conclusion, we found that the SNP rs398652 on 14q21 was associated with longer telomere length and a reduced risk of bladder cancer and that a portion of the effect of this SNP on bladder cancer risk was mediated by telomere length...
  48. pmc Influence of subjective social status on the relationship between positive outcome expectations and experimentation with cigarettes
    Anna V Wilkinson
    Department of Epidemiology, The University of Texas M D Anderson Cancer Center, Houston, TX 77230 1439, USA
    J Adolesc Health 44:342-8. 2009
    ..The goal of this study was to test the hypothesis that SSS moderates the relationship between POE and experimentation with cigarettes...
  49. pmc Molecular epidemiology, cancer-related symptoms, and cytokines pathway
    Cielito C Reyes-Gibby
    Department of Epidemiology, Division of Cancer Prevention and Population Sciences, The University of Texas, MD Anderson Cancer Center, Houston, TX 77030 4009, USA
    Lancet Oncol 9:777-85. 2008
    ..Likewise, they could identify subgroups who might benefit most from symptom intervention, and contribute to developing personalized and more effective therapies for persistent symptoms...
  50. pmc The influence of tumor necrosis factor-alpha -308 G/A and IL-6 -174 G/C on pain and analgesia response in lung cancer patients receiving supportive care
    Cielito C Reyes-Gibby
    Department of Epidemiology, Division of Cancer Prevention, The University of Texas M D Anderson Cancer Center, 1155 Pressler Street Unit 1340, Houston, TX 77030 4009, USA
    Cancer Epidemiol Biomarkers Prev 17:3262-7. 2008
    ....
  51. pmc Detection of disease-associated deletions in case-control studies using SNP genotypes with application to rheumatoid arthritis
    Chih Chieh Wu
    Unit 1340, Department of Epidemiology, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Hum Genet 126:303-15. 2009
    ..We detected disease-associated deletions within the region of human leukocyte antigen in which genomic deletions were previously discovered in rheumatoid arthritis patients...
  52. pmc Polymorphisms of LIG4, BTBD2, HMGA2, and RTEL1 genes involved in the double-strand break repair pathway predict glioblastoma survival
    Yanhong Liu
    Departments of Epidemiology, Neuro Oncology, and Pathology, TheUniversity of Texas MD Anderson CancerCente, Houston, TX 77030, USA
    J Clin Oncol 28:2467-74. 2010
    ..Therefore, identifying the genetic variants that influence this small number of unusually long-term survivors may provide important insight into tumor biology and treatment...
  53. pmc Effects of measured susceptibility genes on cancer risk in family studies
    Chih Chieh Wu
    Department of Epidemiology, Unit 1340, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Hum Genet 127:349-57. 2010
    ....
  54. pmc Gamma-radiation sensitivity and polymorphisms in RAD51L1 modulate glioma risk
    Yanhong Liu
    Department of Epidemiology, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Carcinogenesis 31:1762-9. 2010
    ..However, polymorphisms in DNA strand break repair genes that may determine mutagen sensitivity are not well studied in cancer risk, especially in gliomas...
  55. pmc Exposure to smoking imagery in the movies and experimenting with cigarettes among Mexican heritage youth
    Anna V Wilkinson
    Department of Epidemiology, The University of Texas M D Anderson Cancer Center, Houston, 77030, USA
    Cancer Epidemiol Biomarkers Prev 18:3435-43. 2009
    ..Among Mexican-born youth, exposure to smoking imagery in the movies may be an important part of the acculturation process associated with smoking initiation...
  56. pmc Association of the C8orf13-BLK region with systemic sclerosis in North-American and European populations
    Pravitt Gourh
    Division of Rheumatology and Clinical Immunogenetics, Department of Internal Medicine, University of Texas Health Science Center at Houston UTHSC H, Houston, TX 77030, USA
    J Autoimmun 34:155-62. 2010
    ..The current report sought to determine if polymorphisms in the C8orf13-BLK region (chromosome 8p23.1-B lymphoid tyrosine kinase), which is associated with SLE, are associated also with SSc...
  57. pmc Neuropathic pain in breast cancer survivors: using the ID pain as a screening tool
    Cielito Reyes-Gibby
    Department of Epidemiology, Division of Cancer Prevention, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030 4009, USA
    J Pain Symptom Manage 39:882-9. 2010
    ..This study provides evidence for ID Pain as a valid screening measure for NP in breast cancer survivors...
  58. pmc Role of inflammation gene polymorphisms on pain severity in lung cancer patients
    Cielito C Reyes-Gibby
    Department of Epidemiology, Division of Cancer Prevention, The University of Texas M D Anderson Cancer Center, Unit 1340, 1155 Pressler Street, Houston, TX 77030 4009, USA
    Cancer Epidemiol Biomarkers Prev 18:2636-42. 2009
    ..This study suggests the importance of inflammation gene polymorphisms in modulating pain severity. Additional studies are needed to validate our findings...
  59. pmc Genetic and nongenetic covariates of pain severity in patients with adenocarcinoma of the pancreas: assessing the influence of cytokine genes
    Cielito C Reyes-Gibby
    Department of Epidemiology, Division of Cancer Prevention, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030 4009, USA
    J Pain Symptom Manage 38:894-902. 2009
    ..23, 95% CI=1.4, 4.7) for severe pain relative to the AA genotypes. We provide preliminary evidence of the role of IL-8 in the severity of pain in pancreatic cancer patients. Additional studies are needed in larger cohorts of patients...
  60. pmc Chemotherapy-induced peripheral neuropathy as a predictor of neuropathic pain in breast cancer patients previously treated with paclitaxel
    Cielito C Reyes-Gibby
    Department of Epidemiology, The University of Texas M D Anderson Cancer Center, Houston, 77030, USA
    J Pain 10:1146-50. 2009
    ..5% versus 45%; P = .08) for pain than those without NP. The results of this study confirm that CIPN is a predictor of NP, suggesting that survivors treated with paclitaxel should be regularly monitored for NP beyond treatment...
  61. pmc Finding factors influencing risk: comparing Bayesian stochastic search and standard variable selection methods applied to logistic regression models of cases and controls
    Michael D Swartz
    Department of Epidemiology, Unit 1340, UTMD Anderson Cancer Center, Houston, TX 77230 1439, USA
    Stat Med 27:6158-74. 2008
    ..This study shows that the Bayesian methods offer a way to use prior information to both increase power and decrease false-positive results when selecting factors to model complex disease risk...
  62. pmc Genome-wide association scan of tag SNPs identifies a susceptibility locus for lung cancer at 15q25.1
    Christopher I Amos
    Department of Epidemiology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Nat Genet 40:616-22. 2008
    ..Haplotype analysis was consistent with there being a single risk variant in this region. We conclude that variation in a region of 15q25.1 containing nicotinic acetylcholine receptors genes contributes to lung cancer risk...
  63. ncbi request reprint Positional identification of microdeletions with genetic markers
    Christopher I Amos
    Department of Epidemiology, M D Anderson Cancer Center, Houston, TX 77030, USA
    Hum Hered 56:107-18. 2003
    ..On the other hand, heterogeneity of causation, with only some families showing a microdeletion had a more severe influence upon the ability to identify de novo microdeletions...
  64. ncbi request reprint Androgen receptor polymorphisms and risk of biochemical failure among prostatectomy patients
    Sara S Strom
    Department of Epidemiology, The University of Texas M D Anderson Cancer Center, Houston, Texas, USA
    Prostate 60:343-51. 2004
    ..Little is known about the role of inherited genotypes in prostate cancer (PC) progression. This prospective study evaluated the predictive value of androgen receptor (AR) polymorphisms (CAG and GGC repeats) among prostatectomy patients...
  65. ncbi request reprint Linkage analysis of affected sib pairs allowing for parent-of-origin effects
    Chih Chieh Wu
    Department of Epidemiology, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Unit 189, Houston, TX 77030, USA
    Ann Hum Genet 69:113-26. 2005
    ..We also provide useful strategies to determine the optimal tests to use while performing a genome scan...
  66. ncbi request reprint Genetic mapping of a third Li-Fraumeni syndrome predisposition locus to human chromosome 1q23
    Linda L Bachinski
    Section of Cancer Genetics, Department of Molecular Genetics, University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Cancer Res 65:427-31. 2005
    ..Identification ofa third predisposing gene and its underlying mutation(s) should provide insight into other genetic events that predispose to the genesis of the diverse tumor types associated with LFS and its variants...
  67. ncbi request reprint p53 Genotypes and Haplotypes Associated With Lung Cancer Susceptibility and Ethnicity
    Xifeng Wu
    Department of Epidemiology, The University of Texas M D Anderson Cancer Center, Houston, 77030, USA
    J Natl Cancer Inst 94:681-90. 2002
    ..We also examined the functionality of the p53 variants in apoptosis and DNA repair...
  68. ncbi request reprint Joint effects of germ-line p53 mutation and sex on cancer risk in Li-Fraumeni syndrome
    Chih Chieh Wu
    Department of Epidemiology, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Cancer Res 66:8287-92. 2006
    ..1-fold higher odds of having cancer than did men with mutations (95% CI, 2.5-20.3). These findings provide quantitative cancer risk assessments for LFS families...
  69. pmc Exploring joint effects of genes and the clinical efficacy of morphine for cancer pain: OPRM1 and COMT gene
    Cielito C Reyes-Gibby
    Department of Epidemiology, U T M D Anderson Cancer Center, Houston, TX, USA
    Pain 130:25-30. 2007
    ..Future studies are needed to further characterize the joint effects of multiple genes, along with demographic and clinical variables, in predicting opioid dose...
  70. ncbi request reprint A risk model for prediction of lung cancer
    Margaret R Spitz
    Department of Epidemiology Unit 1340, The University of Texas M D Anderson Cancer Center, PO Box 301439, Houston, TX 77230 1439, USA
    J Natl Cancer Inst 99:715-26. 2007
    ..Reliable risk prediction tools for estimating individual probability of lung cancer have important public health implications. We constructed and validated a comprehensive clinical tool for lung cancer risk prediction by smoking status...
  71. ncbi request reprint Imprinting detection by extending a regression-based QTL analysis method
    Olga Y Gorlova
    Department of Epidemiology, MD Anderson Cancer Center, University of Texas, Unit 1340, 1155 Pressler Street, Houston, TX 77030, USA
    Hum Genet 122:159-74. 2007
    ..A parent-of-origin effect consistent with maternal imprinting was suggested at 99.67-111.26 Mb for body mass index, bioelectrical impedance analysis, waist circumference, and leptin concentration...
  72. ncbi request reprint Cytokine genes and pain severity in lung cancer: exploring the influence of TNF-alpha-308 G/A IL6-174G/C and IL8-251T/A
    Cielito C Reyes-Gibby
    Department of Epidemiology, Division of Cancer Prevention, The University of Texas M D Anderson Cancer Center, Unit 1340, 1155 Pressler Street, Houston, TX 77030 4009, USA
    Cancer Epidemiol Biomarkers Prev 16:2745-51. 2007
    ..We explored if polymorphisms in candidate cytokine genes could explain variability in self-reported pain in lung cancer patients of all stages...
  73. pmc Genome-wide mapping of modifier chromosomal loci for human hypertrophic cardiomyopathy
    E Warwick Daw
    Department of Epidemiology, MD Anderson Cancer Center, Houston, TX 77030, USA
    Hum Mol Genet 16:2463-71. 2007
    ....
  74. ncbi request reprint Statistical methods for anomalous discrete time series based on minimum cell count
    Chih Chieh Wu
    Department of Epidemiology, Unit 1340, The University of Texas M D Anderson Cancer Center, 1155 Pressler Street, Houston, Texas 77030, USA
    Biom J 50:86-96. 2008
    ..Data on a temporal series of adolescent suicide from the US National Center for Health Statistics were analyzed using these methods...
  75. pmc Sensation seeking, risk behaviors, and alcohol consumption among Mexican origin youth
    Anna V Wilkinson
    Department of Epidemiology, University of Texas M D Anderson Cancer Center, Houston, TX 77230, USA
    J Adolesc Health 48:65-72. 2011
    ..To examine factors associated with ever use of alcohol among Mexican origin youth...
  76. ncbi request reprint Genome-wide association study identifies five susceptibility loci for glioma
    Sanjay Shete
    Department of Epidemiology, The University of Texas M D Anderson Cancer Center, Houston, Texas, USA
    Nat Genet 41:899-904. 2009
    ..3 (rs498872, PHLDB1; P = 1.07 x 10(-8)). These data show that common low-penetrance susceptibility alleles contribute to the risk of developing glioma and provide insight into disease causation of this primary brain tumor...
  77. ncbi request reprint Perception among upper middle class adolescent in Bombay regarding sex and sexuality
    M S Selvan
    Dept of Epidemiology, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Blvd, Houston, Texas 77030, USA
    Indian J Public Health 49:250-1. 2005
    ..However, there were significant differences between the responses of male and female adolescents...
  78. pmc HER-2 gene amplification can be acquired as breast cancer progresses
    Songdong Meng
    Cancer Immunobiology Center, University of Texas Southwestern Medical Center, 6000 Harry Hines Boulevard, Dallas, TX 75390, USA
    Proc Natl Acad Sci U S A 101:9393-8. 2004
    ..e., 37.5% (95% confidence interval of 18.8-59.4%). Four of the 9 patients were treated with Herceptin-containing therapy. One had a complete response and 2 had a partial response...
  79. ncbi request reprint Data mining of RNA expression and DNA genotype data: presentation group 5 contributions to Genetic Analysis Workshop 15
    Catherine T Falk
    Genet Epidemiol 31:S43-50. 2007
    ..The collection of papers and methods offer a starting point for further exploration of complex interactions in human genetic data now readily available...
  80. ncbi request reprint Lack of an association between the angiotensin-converting enzyme insertion/deletion polymorphism and intracranial aneurysms in a Caucasian population in the United States
    Hariyadarshi Pannu
    Department of Internal Medicine and Neurosurgery, The University of Texas Medical School at Houston, Texas, USA
    J Neurosurg 103:92-6. 2005
    ....
  81. ncbi request reprint The role of MMP-2 and MMP-9 polymorphisms in sporadic intracranial aneurysms
    Hariyadarshi Pannu
    Department of Internal Medicine and Neurosurgery, The University of Texas Medical School at Houston, USA
    J Neurosurg 105:418-23. 2006
    ....
  82. ncbi request reprint Improving the power of sib pair quantitative trait loci detection by phenotype winsorization
    Jose R Fernandez
    Department of Nutrition Sciences, Division of Physiology and Metabolism, The University of Alabama at Birmingham, 35294 3360, USA
    Hum Hered 53:59-67. 2002
    ..We evaluated the robustness and power of reducing the influence of subjects with extreme phenotypic values by Winsorizing non-normal distributions in three versions of Haseman-Elston regression-based methods of QTL linkage analysis...
  83. ncbi request reprint Genetic linkage and imprinting effects on body mass index in children and young adults
    Olga Y Gorlova
    Department of Epidemiology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
    Eur J Hum Genet 11:425-32. 2003
    ..1-q32 (maternal expression), 10p14-q11 (paternal expression), and 12p12-pter (paternal expression) in children, and 4q31-qter (paternal expression) and 8p (paternal expression) in adults...
  84. ncbi request reprint The worldwide distribution of the VHL 598C>T mutation indicates a single founding event
    Enli Liu
    Baylor College of Medicine and Veterans Affairs Medical Center, Houston, TX, USA
    Blood 103:1937-40. 2004
    ..Haplotype analysis indicated a founder effect. We conclude that the VHL 598C>T mutation, the most common defect of congenital polycythemia yet found, was spread from a single founder 1,000 to 62,000 years ago...
  85. ncbi request reprint Promoter polymorphism (-786t>C) in the endothelial nitric oxide synthase gene is associated with risk of sporadic breast cancer in non-Hispanic white women age younger than 55 years
    Jiachun Lu
    Department of Epidemiology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Cancer 107:2245-53. 2006
    ..Most breast cancers develop from mammary epithelial cells; therefore, NO may play a role in their development. It was hypothesized that eNOS polymorphisms are associated with risk of breast cancer...
  86. ncbi request reprint Mutations in transforming growth factor-beta receptor type II cause familial thoracic aortic aneurysms and dissections
    Hariyadarshi Pannu
    Department of Internal Medicine, Institute of Molecular Medicine, The University of Texas Health Science Center, Houston, TX, USA
    Circulation 112:513-20. 2005
    ..Having mapped a TAAD locus to 3p24-25, we sequenced the gene for transforming growth factor-beta receptor type II (TGFBR2) to determine whether mutations in this gene resulted in familial TAAD...
  87. ncbi request reprint Linkage analyses of rheumatoid arthritis and related quantitative phenotypes: the GAW15 experience
    Saurabh Ghosh
    Human Genetics Unit, Indian Statistical Institute, 203 B T Road, Kolkata 700 108, India
    Genet Epidemiol 31:S86-95. 2007
    ..In this report, we discuss the different strategies explored by the different investigators with the common goal of improving the power to detect linkage...
  88. ncbi request reprint Circulating tumor cells in patients with breast cancer dormancy
    Songdong Meng
    Cancer Immunobiology Center, University of Texas Southwestern Medical Center, Dallas, Texas 75390 8576, USA
    Clin Cancer Res 10:8152-62. 2004
    ....

Research Grants3

  1. Statistical Methods for Gene-Gene and Gene-Environment *
    Sanjay Shete; Fiscal Year: 2004
    ..D. Anderson Cancer Center in an ongoing study of genetic susceptibility to lung cancer. ..
  2. Genome Wide Association Study of Head and Neck Cancer
    Sanjay Shete; Fiscal Year: 2009
    ....
  3. Genome Wide Association Study of Head and Neck Cancer
    Sanjay Shete; Fiscal Year: 2010
    ....