Yu Shen

Summary

Affiliation: The University of Texas
Country: USA

Publications

  1. pmc Tamoxifen chemoprevention treatment and time to first diagnosis of estrogen receptor-negative breast cancer
    Yu Shen
    Department of Biostatistics, The University of Texas MD Anderson Cancer Center, Houston, TX 77030 4095, USA
    J Natl Cancer Inst 100:1448-53. 2008
  2. ncbi request reprint Nonparametric estimation of asymptomatic duration from a randomized prospective cancer screening trial
    Yu Shen
    Department of Biostatistics and Applied Mathematics, MD Anderson Cancer Center, University of Texas, Houston, 77030, USA
    Biometrics 61:992-9. 2005
  3. ncbi request reprint A model-based comparison of breast cancer screening strategies: mammograms and clinical breast examinations
    Yu Shen
    Department of Biostatistics and Applied Mathematics, M D Anderson Cancer Center University of Texas, 1515 Holcombe Boulevard, Box 447, Houston, TX 77030, USA
    Cancer Epidemiol Biomarkers Prev 14:529-32. 2005
  4. pmc Patterns of treatment for early stage breast cancers at the M. D. Anderson Cancer Center from 1997 to 2004
    Yu Shen
    Department of Biostatistics, The University of Texas M D Anderson Cancer Center, Houston, Texas, USA
    Cancer 115:2041-51. 2009
  5. ncbi request reprint Robust modeling in screening studies: estimation of sensitivity and preclinical sojourn time distribution
    Yu Shen
    Department of Biostatistics and Applied Mathematics, M D Anderson Cancer Center, University of Texas, Houston, TX 77030, USA
    Biostatistics 6:604-14. 2005
  6. ncbi request reprint Adaptive design: estimation and inference with censored data in a semiparametric model
    Yu Shen
    Department of Biostatistics, M D Anderson Cancer Center, Houston, TX 77030, USA
    Biostatistics 8:306-22. 2007
  7. ncbi request reprint Are there racial differences in breast cancer treatments and clinical outcomes for women treated at M.D. Anderson Cancer Center?
    Yu Shen
    Department of Biostatistics and Applied Mathematics, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Blvd, Unit 447, Houston, TX 77030, USA
    Breast Cancer Res Treat 102:347-56. 2007
  8. pmc Neoadjuvant chemotherapy in small cell urothelial cancer improves pathologic downstaging and long-term outcomes: results from a retrospective study at the MD Anderson Cancer Center
    Siobhan P Lynch
    Department of Cancer Medicine, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
    Eur Urol 64:307-13. 2013
  9. ncbi request reprint Role of detection method in predicting breast cancer survival: analysis of randomized screening trials
    Yu Shen
    Department of Biostatistics and Applied Mathematics, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX 77030, USA
    J Natl Cancer Inst 97:1195-203. 2005
  10. pmc Prognostic role of detection method and its relationship with tumor biomarkers in breast cancer: the university of Texas M.D. Anderson Cancer Center experience
    Wenli Dong
    Department of Biostatistics, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
    Cancer Epidemiol Biomarkers Prev 17:1096-103. 2008

Detail Information

Publications67

  1. pmc Tamoxifen chemoprevention treatment and time to first diagnosis of estrogen receptor-negative breast cancer
    Yu Shen
    Department of Biostatistics, The University of Texas MD Anderson Cancer Center, Houston, TX 77030 4095, USA
    J Natl Cancer Inst 100:1448-53. 2008
    ..Its effect on the time to first diagnosis of breast cancer has not been reported. We used information from the randomized, placebo-controlled Breast Cancer Prevention Trial (BCPT) to make that evaluation...
  2. ncbi request reprint Nonparametric estimation of asymptomatic duration from a randomized prospective cancer screening trial
    Yu Shen
    Department of Biostatistics and Applied Mathematics, MD Anderson Cancer Center, University of Texas, Houston, 77030, USA
    Biometrics 61:992-9. 2005
    ..We illustrate the methodology using data from a randomized breast cancer screening trial...
  3. ncbi request reprint A model-based comparison of breast cancer screening strategies: mammograms and clinical breast examinations
    Yu Shen
    Department of Biostatistics and Applied Mathematics, M D Anderson Cancer Center University of Texas, 1515 Holcombe Boulevard, Box 447, Houston, TX 77030, USA
    Cancer Epidemiol Biomarkers Prev 14:529-32. 2005
    ..Annual mammography combined with CBE every 6 months will lead to a 41% increase in the quality-adjusted life years compared with annual mammography and CBE from 50 to 79, whereas the total cost increases by 30%...
  4. pmc Patterns of treatment for early stage breast cancers at the M. D. Anderson Cancer Center from 1997 to 2004
    Yu Shen
    Department of Biostatistics, The University of Texas M D Anderson Cancer Center, Houston, Texas, USA
    Cancer 115:2041-51. 2009
    ..D. Anderson Cancer Center (MDACC)...
  5. ncbi request reprint Robust modeling in screening studies: estimation of sensitivity and preclinical sojourn time distribution
    Yu Shen
    Department of Biostatistics and Applied Mathematics, M D Anderson Cancer Center, University of Texas, Houston, TX 77030, USA
    Biostatistics 6:604-14. 2005
    ..The different estimation methods provide complimentary tools to obtain the unknown parameters. The methods are applied to three breast cancer early-detection trials...
  6. ncbi request reprint Adaptive design: estimation and inference with censored data in a semiparametric model
    Yu Shen
    Department of Biostatistics, M D Anderson Cancer Center, Houston, TX 77030, USA
    Biostatistics 8:306-22. 2007
    ..Extensive simulation studies show that the asymptotic confidence intervals have reasonable nominal probability of coverage, and the proposed point estimators are nearly unbiased with practical sample sizes...
  7. ncbi request reprint Are there racial differences in breast cancer treatments and clinical outcomes for women treated at M.D. Anderson Cancer Center?
    Yu Shen
    Department of Biostatistics and Applied Mathematics, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Blvd, Unit 447, Houston, TX 77030, USA
    Breast Cancer Res Treat 102:347-56. 2007
    ..To determine the influence of race on breast cancer treatment and on recurrence and breast cancer specific death...
  8. pmc Neoadjuvant chemotherapy in small cell urothelial cancer improves pathologic downstaging and long-term outcomes: results from a retrospective study at the MD Anderson Cancer Center
    Siobhan P Lynch
    Department of Cancer Medicine, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
    Eur Urol 64:307-13. 2013
    ..Small cell urothelial carcinoma (SCUC) is a rare, aggressive malignancy with a propensity for early microscopic metastases. Data suggest that neoadjuvant chemotherapy may lead to improved survival compared with initial surgery...
  9. ncbi request reprint Role of detection method in predicting breast cancer survival: analysis of randomized screening trials
    Yu Shen
    Department of Biostatistics and Applied Mathematics, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX 77030, USA
    J Natl Cancer Inst 97:1195-203. 2005
    ..We also address whether method of detection is an independent prognostic factor in breast cancer...
  10. pmc Prognostic role of detection method and its relationship with tumor biomarkers in breast cancer: the university of Texas M.D. Anderson Cancer Center experience
    Wenli Dong
    Department of Biostatistics, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
    Cancer Epidemiol Biomarkers Prev 17:1096-103. 2008
    ..To assess the effect of tumor detection method (screening versus symptom-based diagnosis) in predicting breast cancer survival and investigate how biological features of breast cancer are related to the tumor detection method...
  11. ncbi request reprint Prognostic factors and risk assessment in chronic myelomonocytic leukemia: validation study of the M.D. Anderson Prognostic Scoring System
    Miloslav Beran
    Department of Leukemia, The University of Texas M D Anderson Cancer Center, Houston, TX 77230, USA
    Leuk Lymphoma 48:1150-60. 2007
    ....
  12. ncbi request reprint The proteasome inhibitor bortezomib synergizes with gemcitabine to block the growth of human 253JB-V bladder tumors in vivo
    Ashish M Kamat
    Department of Urology, University of Texas MD Anderson Cancer Center, Houston, TX, USA
    Mol Cancer Ther 3:279-90. 2004
    ..Together, our results demonstrate that bortezomib has significant antiproliferative activity in aggressive bladder cancer cells, which is best exploited within the context of combination chemotherapy...
  13. pmc A phase 2 clinical trial of sequential neoadjuvant chemotherapy with ifosfamide, doxorubicin, and gemcitabine followed by cisplatin, gemcitabine, and ifosfamide in locally advanced urothelial cancer: final results
    Arlene O Siefker-Radtke
    Department of Genitourinary Medical Oncology, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Cancer 119:540-7. 2013
    ..Sequential chemotherapy also has not been well studied in the neoadjuvant setting. The authors explored sequential neoadjuvant ifosfamide-based chemotherapy in a patient cohort at high risk of noncurative cystectomy...
  14. pmc CD8 tumor-infiltrating lymphocytes are predictive of survival in muscle-invasive urothelial carcinoma
    Padmanee Sharma
    Department of Genitourinary Medical Oncology, University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Proc Natl Acad Sci U S A 104:3967-72. 2007
    ..001) and overall survival (P = 0.018) than did patients with similar-staged UC and fewer intratumoral CD8 TILs. We conclude that the extent of intratumoral CD8 TILs is an important prognostic indicator in advanced UC...
  15. pmc Cost-effectiveness analysis of mammography and clinical breast examination strategies: a comparison with current guidelines
    Charlotte Hsieh Ahern
    Department of Medicine, The Dan L Duncan Cancer Center at Baylor College of Medicine, Houston, TX 77030 4009, USA
    Cancer Epidemiol Biomarkers Prev 18:718-25. 2009
    ..We considered costs of screening examinations, subsequent work-up, biopsy, and treatment interventions after diagnosis...
  16. ncbi request reprint Surveillance for recurrent bladder cancer using a point-of-care proteomic assay
    H Barton Grossman
    Department of Urology, M D Anderson Cancer Center, Houston, Tex 77030, USA
    JAMA 295:299-305. 2006
    ..At least 50% of patients with a history of bladder cancer have recurrences, so rigorous surveillance is necessary. Cystoscopy is standard but can fail to detect some bladder cancers, so a urine test is frequently part of the evaluation...
  17. ncbi request reprint Soluble vascular endothelial growth factor receptor 1, and not receptor 2, is an independent prognostic factor in acute myeloid leukemia and myelodysplastic syndromes
    Qinglong Hu
    Department of Hematopathology, The University of Texas M D Anderson Cancer Center, Houston, Texas, USA
    Cancer 100:1884-91. 2004
    ..Vascular endothelial growth factor (VEGF) and its receptors (VEGFRs) are major regulators of angiogenesis, which plays a key role in the growth and dissemination of solid tumors and hematologic neoplasms...
  18. doi request reprint Randomized phase II trial evaluation of erectile function after attempted unilateral cavernous nerve-sparing retropubic radical prostatectomy with versus without unilateral sural nerve grafting for clinically localized prostate cancer
    John W Davis
    Department of Urology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Eur Urol 55:1135-43. 2009
    ..Nonrandomized studies of unilateral nerve-sparing (UNS) radical prostatectomy (RP) have reported improved recovery of erectile function if the sacrificed cavernous nerve is reconstructed with a sural nerve graft (SNG)...
  19. ncbi request reprint Adaptive design and estimation in randomized clinical trials with correlated observations
    Guosheng Yin
    Department of Biostatistics and Applied Mathematics, M D Anderson Cancer Center, The University of Texas, Houston, Texas 77030, USA
    Biometrics 61:362-9. 2005
    ..Estimation of the parameter of interest and its confidence interval are proposed. We conduct simulation studies to examine the operating characteristics and illustrate the proposed method with an example...
  20. ncbi request reprint Evidence supporting preoperative chemotherapy for small cell carcinoma of the bladder: a retrospective review of the M. D. Anderson cancer experience
    Arlene O Siefker-Radtke
    Center for Genitourinary Oncology, and Department of Genitourinary Medical Oncology, The University of Texas M D Anderson Cancer Center, Houston, 77030 4009, USA
    J Urol 172:481-4. 2004
    ..Neuroendocrine tumors of the bladder comprise a small subset of all bladder tumors. To improve our understanding of this tumor and define outcomes with current management, we performed a retrospective review of these cases...
  21. ncbi request reprint C-kit receptor expression in acute leukemias-association with patient and disease characteristics and with outcome
    Anne S Tsao
    MD Anderson Cancer Center, University of Texas, 1515 Holcombe Boulevard, P O Box 428 Houston, TX 77030, USA
    Leuk Res 28:373-8. 2004
    ..However, after accounting for these covariates, multivariate analysis indicates that higher c-kit expression predicts higher CR rates, although there was no effect on DFS in CR...
  22. ncbi request reprint Prognostic significance of monocytosis in patients with myeloproliferative disorders
    Miloslav Beran
    Departments of Leukemia, UT MD Anderson Cancer Center, PO Box 301402, Houston, TX 77230, USA
    Leuk Lymphoma 47:417-23. 2006
    ..The diagnosis of CMML is prognostically significant and independently associated with a shorter survival and a higher risk of death than BCR/ABL-negative CML or Ph(1-) BCR/ABL-unknown CML...
  23. ncbi request reprint Myelodysplastic syndrome is not merely "preleukemia"
    Maher Albitar
    Department of Hematopathology, The University of Texas MD Anderson Cancer Center, Houston 77030 4095, USA
    Blood 100:791-8. 2002
    ....
  24. ncbi request reprint Multimodality management of urachal carcinoma: the M. D. Anderson Cancer Center experience
    Arlene O Siefker-Radtke
    Center for Genitourinary Oncology, Department of Genitourinary Medical Oncology, The University of Texas M D Anderson Cancer Center, Houston, USA
    J Urol 169:1295-8. 2003
    ..To improve our understanding of urachal carcinoma and define outcome with current management, we performed a retrospective review of cases seen at the M. D. Anderson Cancer Center...
  25. doi request reprint Randomized trial of adjuvant thalidomide versus observation in patients with completely resected high-risk renal cell carcinoma
    Vitaly Margulis
    Department of Urology, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA
    Urology 73:337-41. 2009
    ..To evaluate the effect of adjuvant thalidomide on recurrence-free survival (RFS) after nephrectomy for high-risk metastatic renal cell carcinoma (RCC)...
  26. ncbi request reprint A Bayesian approach to jointly modeling toxicity and biomarker expression in a phase I/II dose-finding trial
    B Nebiyou Bekele
    Department of Biostatistics and Applied Mathematics, The University of Texas, M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, Texas 77030, USA
    Biometrics 61:343-54. 2005
    ..Extensive simulation studies show that the design reliably chooses the preferred dose using both toxicity and expression outcomes under various clinical scenarios...
  27. ncbi request reprint Pharmacodynamic analysis of target inhibition and endothelial cell death in tumors treated with the vascular endothelial growth factor receptor antagonists SU5416 or SU6668
    Darren W Davis
    Department of Cancer Biology, University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
    Clin Cancer Res 11:678-89. 2005
    ....
  28. pmc Correlation between CpG methylation profiles and hormone receptor status in breast cancers
    Weiwei Feng
    Department of Experimental Therapeutics, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX 77030, USA
    Breast Cancer Res 9:R57. 2007
    ..The present study was undertaken to determine whether methylation of a set of growth-suppressor genes would correlate to the expression of estrogen receptors (ERs) and progesterone receptors (PRs)...
  29. ncbi request reprint Estimation of age-specific sensitivity and sojourn time in breast cancer screening studies
    Xiuyu J Cong
    Department of Statistics, Rice University, Houston, TX 77005, USA
    Stat Med 24:3123-38. 2005
    ..The proposed methods are illustrated using data from two large breast cancer screening trials. The results show that the screening sensitivity increases with age at screening examinations based on these two trials...
  30. pmc Monitoring late-onset toxicities in phase I trials using predicted risks
    B Nebiyou Bekele
    Department of Biostatistics, MD Anderson Cancer Center, Houston, TX 77030, USA
    Biostatistics 9:442-57. 2008
    ..This advantage increases with accrual rate, but the price of this additional safety is that the trial takes longer to complete on average...
  31. ncbi request reprint Symptomatic local recurrence of prostate carcinoma after radiation therapy
    Dan Leibovici
    Department of Urology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Cancer 103:2060-6. 2005
    ..Most reports on the results of RT for localized prostate carcinoma (PC) do not address this endpoint. The objective of this study was to determine the incidence of SLRPC and to identify the risk factors for this endpoint...
  32. ncbi request reprint Self-designing trial combined with classical group sequential monitoring
    Guosheng Yin
    Department of Biostatistics and Applied Mathematics, M D Anderson Cancer Center, The University of Texas, Houston, Texas, USA
    J Biopharm Stat 15:667-75. 2005
    ..The futility stopping rule allows the trial to be terminated when there is no beneficial treatment effect. We conduct simulation studies to evaluate the performance of the proposed design...
  33. ncbi request reprint Liposomal amphotericin B versus the combination of fluconazole and itraconazole as prophylaxis for invasive fungal infections during induction chemotherapy for patients with acute myelogenous leukemia and myelodysplastic syndrome
    Gloria N Mattiuzzi
    Department of Leukemia, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Cancer 97:450-6. 2003
    ..The authors evaluated the efficacy and toxicity of liposomal amphotericin B (L-AmB) compared with a combination of fluconazole plus itraconazole (F+I) as prophylaxis in this setting...
  34. doi request reprint Analysis of the expression of biomarkers in urinary bladder cancer using a tissue microarray
    Loleta D Harris
    Department of Urology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Mol Carcinog 47:678-85. 2008
    ..Although the expression of these genes correlated with factors known to be associated with patient outcome, none of them was an independent predictor of progression-free or overall survival...
  35. pmc p63 expression defines a lethal subset of muscle-invasive bladder cancers
    Woonyoung Choi
    Department of Urology, The University of Texas M D Anderson Cancer Center, Houston, Texas, United States of America
    PLoS ONE 7:e30206. 2012
    ..Previous studies demonstrated that p63 is downregulated in muscle-invasive bladder cancers, but the relationship between p63 expression and survival is not clear...
  36. pmc Buckley-James-type estimator with right-censored and length-biased data
    Jing Ning
    Division of Biostatistics, The University of Texas School of Public Health, Houston, Texas 77030, USA
    Biometrics 67:1369-78. 2011
    ..We assess the finite-sample properties of the proposed estimators against the estimators obtained from the existing methods. Data from a prevalent cohort study of patients with dementia are used to illustrate the proposed methodology...
  37. ncbi request reprint Validation of criteria used to predict extraprostatic cancer extension: a tool for use in selecting patients for nerve sparing radical prostatectomy
    Ashish M Kamat
    Department of Urology, University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    J Urol 174:1262-5. 2005
    ..We present prospectively collected data to validate our results...
  38. ncbi request reprint Quantitative analysis of biomarkers defines an optimal biological dose for recombinant human endostatin in primary human tumors
    Darren W Davis
    Department of Cancer Biology, The University of Texas M D Anderson Cancer Center, Houston, Texas, USA
    Clin Cancer Res 10:33-42. 2004
    ..The results, including tumor blood flow measured by positron emission tomography, were analyzed using a quadratic polynomial model...
  39. ncbi request reprint Comparison between pediatric acute myeloid leukemia (AML) and adult AML in VEGF and KDR (VEGF-R2) protein levels
    Sima Jeha
    Department of Pediatrics, University of Texas, M D Anderson Cancer Center, P O Box 072, 1515 Holcombe Boulevard, Houston, TX 77030, USA
    Leuk Res 26:399-402. 2002
    ..Unlike in adults, VEGF and VEGF-R2 levels in pediatric AML patients did not correlate with survival. This data suggest that the role of VEGF and its receptor VEGF-R2 in pediatrics AML may be different from that in adult AML...
  40. ncbi request reprint Correlation of metastasis related gene expression and relapse-free survival in patients with locally advanced bladder cancer treated with cystectomy and chemotherapy
    Joel W Slaton
    Department of Urology, The University of Texas M D Anderson Cancer Center, Houston, 77030USA
    J Urol 171:570-4. 2004
    ....
  41. pmc Imputation for semiparametric transformation models with biased-sampling data
    Hao Liu
    Division of Biostatistics, Dan L Duncan Cancer Center, Baylor College of Medicine, Houston, TX 77030, USA
    Lifetime Data Anal 18:470-503. 2012
    ..Simulation studies show that under small to moderate sample sizes, the proposed procedure has smaller mean square errors than two existing estimation procedures. Finally, we demonstrate the estimation procedure by a real data example...
  42. pmc Association between contralateral prophylactic mastectomy and breast cancer outcomes by hormone receptor status
    Abenaa M Brewster
    Department of Clinical Cancer Prevention, The University of Texas MD Anderson Cancer Center, Houston, Texas 77230 1439, USA
    Cancer 118:5637-43. 2012
    ..The objective of this study was to evaluate the benefits of CPM using a propensity scoring approach that reduces selection bias from the nonrandom assignment of patients in observational studies...
  43. ncbi request reprint Is there a role for surgery in the management of metastatic urothelial cancer? The M. D. Anderson experience
    Arlene O Siefker-Radtke
    Center for Genitourinary Oncology and Department of Medical Oncology, The University of Texas M D Anderson Cancer Center, Houston, 77030 4009, USA
    J Urol 171:145-8. 2004
    ..The role of surgery for metastatic disease is not well established for urothelial cancer, but is sometimes undertaken in the face of persistent or recurrent disease that can be surgically resected...
  44. ncbi request reprint A renal mass in the setting of a nonrenal malignancy: When is a renal tumor biopsy appropriate?
    Ricardo F Sanchez-Ortiz
    Department of Urology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Cancer 101:2195-201. 2004
    ..In determining whether it represents a metastasis, patients are frequently subjected to percutaneous renal biopsies. The authors evaluated their experience with this dilemma to formulate management guidelines...
  45. ncbi request reprint Detection of bladder cancer using a point-of-care proteomic assay
    H Barton Grossman
    Department of Urology, M D Anderson Cancer Center, Houston, Tex 77030, USA
    JAMA 293:810-6. 2005
    ..Urine tests are frequently part of an evaluation, but have either been nonspecific for cancer or required specialized analysis at a laboratory...
  46. ncbi request reprint Cancer-testis antigens: expression and correlation with survival in human urothelial carcinoma
    Padmanee Sharma
    Department of Genitourinary Medical Oncology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Clin Cancer Res 12:5442-7. 2006
    ..These antigens were evaluated for both the degree of expression and prognostic value in cancer of the urothelium...
  47. pmc Nomogram to predict the benefit of radiation for older patients with breast cancer treated with conservative surgery
    Jeffrey M Albert
    The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
    J Clin Oncol 30:2837-43. 2012
    ..However, it is not known whether this recommendation should extend to other older women. Accordingly, we developed a nomogram to predict the likelihood of long-term breast preservation with and without RT...
  48. ncbi request reprint Clinical significance of plasma endostatin in acute myeloid leukemia/myelodysplastic syndrome
    Raymond Lai
    Department of Hematopathology, The University of Texas M D Anderson Cancer Center, Houston, Texas, USA
    Cancer 94:14-7. 2002
    ..Endostatin, a C-terminal fragment of collagen XVIII, is an endogenous angiogenesis inhibitor. While endostatin is being investigated for its usefulness in treating solid tumors, its significance in hematologic malignancies is unknown...
  49. pmc Prostate cancer incidence in U.S. Air Force aviators compared with non-aviators
    David Rogers
    MD Anderson Cancer Center, Houston, TX 77030, USA
    Aviat Space Environ Med 82:1067-70. 2011
    ..Instead, our study compared prostate cancer incidence rates among officer aviators and non-aviators in the U.S. Air Force (USAF) to reduce confounding by socioeconomic status and frequency of medical exams...
  50. ncbi request reprint Increased apoptosis in metastatic human colonic adenocarcinomas
    Paula M Termuhlen
    Departments of Cancer Biology, Surgical Oncology, University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, Texas 77030, USA
    Cancer Biol Ther 1:58-63. 2002
    ..Our data demonstrate that the molecular events associated with acquisition of the metastatic phenotype sensitize colon cancer cells to some pro-apoptotic stimuli...
  51. ncbi request reprint DNA methylation and environmental exposures in human hepatocellular carcinoma
    Lanlan Shen
    Department of Leukemia, The University of Texas M D Anderson Cancer Center, Houston, 77030, USA
    J Natl Cancer Inst 94:755-61. 2002
    ..To determine whether CIMP is associated with the development of hepatocellular carcinoma (HCC) and with exposure to environmental agents, we examined the methylation status of CpG islands in HCCs from countries with various HCC risks...
  52. ncbi request reprint Estimation of a parameter and its exact confidence interval following sequential sample size reestimation trials
    Yi Cheng
    Department of Mathematical Sciences, Indiana University at South Bend, South Bend, Indiana 46634, USA
    Biometrics 60:910-8. 2004
    ..Extensive simulation studies show that the exact confidence intervals have accurate nominal probability of coverage, and the proposed point estimates are nearly unbiased with practical sample sizes...
  53. ncbi request reprint Marginal analysis of correlated failure time data with informative cluster sizes
    Xiuyu J Cong
    Department of Biometrics and Data Management, Boehringer Ingelheim Pharmaceuticals, P O Box 368, Ridgefield, Connecticut 06877, USA
    Biometrics 63:663-72. 2007
    ..We conduct simulation studies to assess and compare the finite-sample behaviors of the estimators and apply the proposed methods to a dental study as an illustration...
  54. ncbi request reprint Development of a tightly regulated U6 promoter for shRNA expression
    Xiaoyu Lin
    Cancer Research, Global Pharmaceutical Research and Development, AP10 L01, Abbott Laboratories, 100 Abbott Park Road, Abbott Park, IL 60064, USA
    FEBS Lett 577:376-80. 2004
    ..As a consequence of its tighter regulation, the 2O2 system greatly improved the success rate in making inducible knockdown cell lines...
  55. ncbi request reprint [Diagnosis and treatment of urachal remnants with heterotopia sinus: a report of 2 cases]
    Xuan Wen Zhu
    Department of Urology, First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310003, China
    Zhonghua Nan Ke Xue 11:142-4. 2005
    ..To probe into the diagnosis and treatment of urachal remnants with heterotopic sinus...
  56. ncbi request reprint Evaluation of loss of heterozygosity before and after interferon therapy in patients with hepatitis C virus infection who developed hepatocellular carcinoma during follow up
    Seiji Suzuki
    Departments of Clinical Molecular Informative Medicine, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan
    J Gastroenterol Hepatol 18:1364-72. 2003
    ....
  57. ncbi request reprint [Discussion of naive Bayesian algorithm in prognosis prediction of primary liver cancer]
    Yu Shen
    Dept of Bio Medical Engineering, Shanghai Jiaotong University, Shanghai, China
    Space Med Med Eng (Beijing) 17:350-4. 2004
    ..To apply naive Bayesian algorithm in prognosis prediction of primary liver cancer and to predict the survival expectation of patients after transcatheter arterial chemoembolization (TACE)...
  58. ncbi request reprint Evaluating hypoxia-inducible factor-1alpha as a cancer therapeutic target via inducible RNA interference in vivo
    Leiming Li
    Cancer Research, Global Pharmaceutical Research and Development, Abbott Laboratories, Abbott Park, Illinois 60064, USA
    Cancer Res 65:7249-58. 2005
    ..In addition to broad implications on in vivo validation of cancer targets, results from this study will also be instructive for practical applications of HIF-1-based cancer therapeutics...
  59. ncbi request reprint Hypoxia-inducible factor-1 inhibition in combination with temozolomide treatment exhibits robust antitumor efficacy in vivo
    Leiming Li
    Cancer Research, Global Pharmaceutical Research and Development, Abbott Laboratories, Abbott Park, Illinois 60064, USA
    Clin Cancer Res 12:4747-54. 2006
    ..However, these hypotheses have not been rigorously tested in tumor models in vivo. The present study was carried out to evaluate the antitumor efficacy of combining HIF-1 inhibition with angiogenesis inhibitors or cytotoxic agents...
  60. ncbi request reprint Transition to burst synchronization in coupled neuron networks
    Yu Shen
    Department of Chemical Physics, University of Science and Technology of China, Hefei, Anhui, 230026, People s Republic of China
    Phys Rev E Stat Nonlin Soft Matter Phys 77:031920. 2008
    ..A reasonable mechanism behind such phenomena is given by using local mean field approximation, and the role of network topology is also discussed. The case when the neurons are coupled via chemical synapses is also briefly discussed...
  61. ncbi request reprint The clinical significance of soluble CD86 levels in patients with acute myeloid leukemia and myelodysplastic syndrome
    Barry D Hock
    Haematology Research Group, Christchurch Hospital, Christchurch, New Zealand
    Cancer 98:1681-8. 2003
    ..Levels of the soluble form of CD86 (sCD86) are elevated in a proportion of patients with leukemia. Although it is a potential modulator of antitumor responses, the significance of sCD86 in patients with hematologic malignancies is unknown...
  62. pmc Defining the optimal parameters for hairpin-based knockdown constructs
    Leiming Li
    Cancer Research, Global Pharmaceutical Research and Development, AP10, Abbott Laboratories, Abbott Park, Illinois 60064, USA
    RNA 13:1765-74. 2007
    ..Based on the characteristic nucleotide preferences in the functional versus the nonfunctional shRNAs, we developed a computer program that outperforms an advanced siRNA selection algorithm for the enrichment of highly functional shRNAs...
  63. ncbi request reprint Anti-implantation effect of droloxifene in rats and its relationship with anti-estrogenic activity
    Yong Huang
    Shanghai Institute of Materia Media, Shanghai Institute for Biological Sciences, Chinese Academy of Sciences, Graduate School of the Chinese Academy of Sciences, Shanghai 201203, China
    Acta Pharmacol Sin 26:1243-7. 2005
    ..To investigate the anti-implantation effect of droloxifene and study the possible relationship between the anti-estrogenic activity of droloxifene and its anti-implantation effect...
  64. ncbi request reprint Discovery on Target 2007--CHI's Fifth Annual Conference. RNAi for Drug Discovery and Therapeutics
    Yu Shen
    Abbott Laboratories, 100 Abbott Park Road, Abbott Park, IL 60064, USA
    IDrugs 10:848-50. 2007
  65. pmc A chemical genomics screen highlights the essential role of mitochondria in HIF-1 regulation
    Xiaoyu Lin
    Cancer Research and Advanced Technology, Global Pharmaceutical Research and Development, AP10, Abbott Laboratories, 100 Abbott Park Road, Abbott Park, IL 60064, USA
    Proc Natl Acad Sci U S A 105:174-9. 2008
    ..These results also suggest that targeting mitochondrial ROS production might be a highly effective way of blocking HIF-1 activity in tumors...
  66. ncbi request reprint Advances in the development of siRNA-based therapeutics for cancer
    Yu Shen
    Sirna Therapeutics, Abbott Laboratories, 100 Abbott Park Road, Abbott Park, IL 60031, USA
    IDrugs 11:572-8. 2008
    ..An unbiased, independent evaluation of various tumor-delivery approaches will be a critical starting point in identifying the most promising delivery platforms for the development of siRNA-based cancer therapeutics...
  67. ncbi request reprint Generation of cloned goats (Capra hircus) from transfected foetal fibroblast cells, the effect of donor cell cycle
    Xiangang Zou
    The Babraham Institute, Babraham, Cambridge, United Kingdom
    Mol Reprod Dev 61:164-72. 2002
    ..This study demonstrates that a foreign gene, such as the neo-resistant gene, can be introduced into goat foetal fibroblast cells, and that the resulting transgenic cells are capable of being cloned to produce 100% transgenic animals...

Research Grants10

  1. STATISTICAL METHODS FOR BREAST CANCER SCREENING STUDIES
    Yu Shen; Fiscal Year: 2007
    ..abstract_text> ..
  2. STATISTICAL METHODS FOR BREAST CANCER SCREENING STUDIES
    Yu Shen; Fiscal Year: 2003
    ..In summary, the proposed research has the potential to increase the efficiency and reduce the cost of future periodic screening trials. ..
  3. Statistical Methods for Breast Cancer Prevention and Treatment Studies
    Yu Shen; Fiscal Year: 2010
    ..With the proposed analytic methods, the improved estimations of screening benefit and treatment intervention will better inform health policy and clinical practice in breast cancer prevention and treatment. ..