Lanlan Shen

Summary

Affiliation: The University of Texas
Country: USA

Publications

  1. ncbi request reprint DNA methylation changes after 5-aza-2'-deoxycytidine therapy in patients with leukemia
    Allen S Yang
    Department of Leukemia, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Cancer Res 66:5495-503. 2006
  2. ncbi request reprint Optimizing annealing temperature overcomes bias in bisulfite PCR methylation analysis
    Lanlan Shen
    Department of Leukemia, M D Anderson Cancer Center, Houston, TX 77030, USA
    Biotechniques 42:48, 50, 52 passim. 2007
  3. pmc Genome-wide profiling of DNA methylation reveals a class of normally methylated CpG island promoters
    Lanlan Shen
    Department of Leukemia, The University of Texas at M D Anderson Cancer Center, Houston, Texas, USA
    PLoS Genet 3:2023-36. 2007
  4. ncbi request reprint Drug sensitivity prediction by CpG island methylation profile in the NCI-60 cancer cell line panel
    Lanlan Shen
    Department of Leukemia, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Cancer Res 67:11335-43. 2007
  5. doi request reprint Gene silencing in cancer by histone H3 lysine 27 trimethylation independent of promoter DNA methylation
    Yutaka Kondo
    Department of Leukemia, University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, Texas 77030, USA
    Nat Genet 40:741-50. 2008
  6. pmc Identification of novel tumor markers in prostate, colon and breast cancer by unbiased methylation profiling
    Woonbok Chung
    Department of Leukemia, Baylor College of Medicine, Houston, Texas, United States of America
    PLoS ONE 3:e2079. 2008
  7. pmc Integrated genetic and epigenetic analysis identifies three different subclasses of colon cancer
    Lanlan Shen
    Department of Leukemia, University of Texas M D Anderson Cancer Center, Houston, TX 77030
    Proc Natl Acad Sci U S A 104:18654-9. 2007
  8. pmc DNA methylation profiles of primary colorectal carcinoma and matched liver metastasis
    Kazuo Konishi
    Department of Leukemia, Division of Cancer Medicine, The University of Texas M D Anderson Cancer Center, Houston, Texas, United States of America
    PLoS ONE 6:e27889. 2011
  9. pmc Epigenetic-genetic interactions in the APC/WNT, RAS/RAF, and P53 pathways in colorectal carcinoma
    Yutaka Suehiro
    Department of Pathology, Division of Pathology and Laboratory Medicine, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Clin Cancer Res 14:2560-9. 2008
  10. pmc High-throughput methylation profiling by MCA coupled to CpG island microarray
    Marcos R H Estecio
    Department of Leukemia, UT M D Anderson Cancer Center, Houston, Texas 77030, USA
    Genome Res 17:1529-36. 2007

Collaborators

Detail Information

Publications56

  1. ncbi request reprint DNA methylation changes after 5-aza-2'-deoxycytidine therapy in patients with leukemia
    Allen S Yang
    Department of Leukemia, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Cancer Res 66:5495-503. 2006
    ..In conclusion, we show dose-dependent hypomethylation after decitabine at low doses. Increasing the dose, which has been shown previously to result in a reduced response rate, was not accompanied by further hypomethylation...
  2. ncbi request reprint Optimizing annealing temperature overcomes bias in bisulfite PCR methylation analysis
    Lanlan Shen
    Department of Leukemia, M D Anderson Cancer Center, Houston, TX 77030, USA
    Biotechniques 42:48, 50, 52 passim. 2007
  3. pmc Genome-wide profiling of DNA methylation reveals a class of normally methylated CpG island promoters
    Lanlan Shen
    Department of Leukemia, The University of Texas at M D Anderson Cancer Center, Houston, Texas, USA
    PLoS Genet 3:2023-36. 2007
    ....
  4. ncbi request reprint Drug sensitivity prediction by CpG island methylation profile in the NCI-60 cancer cell line panel
    Lanlan Shen
    Department of Leukemia, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Cancer Res 67:11335-43. 2007
    ..Our results confirm that epigenetic profiles are useful in identifying molecular mediators for cancer drug sensitivity (pharmaco-epigenomics)...
  5. doi request reprint Gene silencing in cancer by histone H3 lysine 27 trimethylation independent of promoter DNA methylation
    Yutaka Kondo
    Department of Leukemia, University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, Texas 77030, USA
    Nat Genet 40:741-50. 2008
    ..These data establish EZH2-mediated H3K27triM as a mechanism of tumor-suppressor gene silencing in cancer that is potentially independent of promoter DNA methylation...
  6. pmc Identification of novel tumor markers in prostate, colon and breast cancer by unbiased methylation profiling
    Woonbok Chung
    Department of Leukemia, Baylor College of Medicine, Houston, Texas, United States of America
    PLoS ONE 3:e2079. 2008
    ..Our data identify new targets of transcriptional silencing in cancer, and provide new biomarkers that could be useful in screening for prostate cancer and other cancers...
  7. pmc Integrated genetic and epigenetic analysis identifies three different subclasses of colon cancer
    Lanlan Shen
    Department of Leukemia, University of Texas M D Anderson Cancer Center, Houston, TX 77030
    Proc Natl Acad Sci U S A 104:18654-9. 2007
    ..Together, our integrated genetic and epigenetic analysis reveals that colon cancers correspond to three molecularly distinct subclasses of disease...
  8. pmc DNA methylation profiles of primary colorectal carcinoma and matched liver metastasis
    Kazuo Konishi
    Department of Leukemia, Division of Cancer Medicine, The University of Texas M D Anderson Cancer Center, Houston, Texas, United States of America
    PLoS ONE 6:e27889. 2011
    ..The contribution of DNA methylation to the metastatic process in colorectal cancers (CRCs) is unclear...
  9. pmc Epigenetic-genetic interactions in the APC/WNT, RAS/RAF, and P53 pathways in colorectal carcinoma
    Yutaka Suehiro
    Department of Pathology, Division of Pathology and Laboratory Medicine, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Clin Cancer Res 14:2560-9. 2008
    ....
  10. pmc High-throughput methylation profiling by MCA coupled to CpG island microarray
    Marcos R H Estecio
    Department of Leukemia, UT M D Anderson Cancer Center, Houston, Texas 77030, USA
    Genome Res 17:1529-36. 2007
    ..In summary, MCAM is a suitable technique to discover methylated genes and to profile methylation changes in clinical samples in a high-throughput fashion...
  11. pmc DNA methylation predicts survival and response to therapy in patients with myelodysplastic syndromes
    Lanlan Shen
    Department of Leukemia and Biostatistics, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    J Clin Oncol 28:605-13. 2010
    ..Epigenetic therapy using decitabine, a DNA hypomethylating agent, is clinically effective for the treatment of MDS. Therefore, we investigated the association between DNA methylation and clinical outcome in MDS...
  12. ncbi request reprint Rare CpG island methylator phenotype in ulcerative colitis-associated neoplasias
    Kazuo Konishi
    Department of Leukemia, University of Texas MD Anderson Cancer Center, Houston, Texas, USA
    Gastroenterology 132:1254-60. 2007
    ..Whether this translates into hypermethylation in UC-associated cancers (UC-Cs) is not known...
  13. pmc LINE-1 hypomethylation in cancer is highly variable and inversely correlated with microsatellite instability
    Marcos R H Estecio
    Department of Leukemia, University of Texas M D Anderson Cancer Center, Houston, Texas, United States of America
    PLoS ONE 2:e399. 2007
    ..This study was performed to determine the relationship between DNA hypomethylation, hypermethylation and microsatellite instability in cancer...
  14. pmc Sensitive and specific detection of early gastric cancer with DNA methylation analysis of gastric washes
    Yoshiyuki Watanabe
    Department of Leukemia, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Gastroenterology 136:2149-58. 2009
    ..We hypothesized that methylation analysis of DNA recovered from gastric washes could be used to detect gastric cancer...
  15. pmc Epigenetic maturation in colonic mucosa continues beyond infancy in mice
    Richard Kellermayer
    Department of Pediatrics, Baylor College of Medicine, USDA ARS Children s Nutrition Research Center, Houston, TX 77030, USA
    Hum Mol Genet 19:2168-76. 2010
    ..Transcript Profiling: Gene Expression Omnibus (http://www.ncbi.nlm.nih.gov/geo/), accession numbers: GSE18031 (DNA methylation arrays), GSE19506 (gene expression arrays)...
  16. ncbi request reprint RIL, a LIM gene on 5q31, is silenced by methylation in cancer and sensitizes cancer cells to apoptosis
    Yanis A Boumber
    Department of Leukemia, The University of Texas M D Anderson Cancer Center, 1515 Holcombe, Houston, TX 77030, USA
    Cancer Res 67:1997-2005. 2007
    ..In MDS, RIL methylation is a marker of adverse prognosis independent of chromosome 5 and 7 deletions. Our data suggest that RIL is a good candidate TSG silenced by hypermethylation in cancer...
  17. pmc Aberrant CpG island methylation in acute myeloid leukemia is accentuated at relapse
    Heike Kroeger
    Department of Leukemia, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
    Blood 112:1366-73. 2008
    ..0% to 15.2% (median 10.6%) genes in relapse (P < .001). Our data suggest that DNA methylation is involved in AML progression and provide a rationale for the use of epigenetic agents in remission maintenance...
  18. ncbi request reprint CpG island methylation profiling in human melanoma cell lines
    Carmen S Tellez
    Department of Leukemia, The University of Texas M D Anderson Cancer Center, Houston, Texas, USA
    Melanoma Res 19:146-55. 2009
    ..We conclude that aberrant hypermethylation, is frequent in melanoma cell lines, directly correlated with global DNA methylation, and independent of BRAF and NRAS mutations...
  19. pmc Concordant DNA methylation in synchronous colorectal carcinomas
    Kazuo Konishi
    Department of Leukemia, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Cancer Prev Res (Phila) 2:814-22. 2009
    ..Screening for and secondary prevention of colon cancer should take this fact into account...
  20. pmc Association between DNA methylation and shortened survival in patients with advanced colorectal cancer treated with 5-fluorouracil based chemotherapy
    Lanlan Shen
    The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA
    Clin Cancer Res 13:6093-8. 2007
    ..We sought to determine the prognostic significance of CIMP in advanced colorectal cancer patients treated with 5-fluorouracil (5-FU) in an Eastern Cooperative Oncology Group clinical trial...
  21. pmc An Sp1/Sp3 binding polymorphism confers methylation protection
    Yanis A Boumber
    Department of Leukemia, MD Anderson Cancer Center, University of Texas, Houston, Texas, United States of America
    PLoS Genet 4:e1000162. 2008
    ..Our finding demonstrates that, in some genes, hypermethylation in cancer is dictated by protein-DNA interactions at the promoters and provides a novel mechanism by which genetic polymorphisms can influence an epigenetic state...
  22. pmc Genome architecture marked by retrotransposons modulates predisposition to DNA methylation in cancer
    Marcos R H Estecio
    Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA
    Genome Res 20:1369-82. 2010
    ....
  23. pmc Comparison and quantitative verification of mapping algorithms for whole-genome bisulfite sequencing
    Govindarajan Kunde-Ramamoorthy
    Department of Pediatrics, Baylor College of Medicine, USDA ARS Children s Nutrition Research Center, Houston, TX 77030, USA, Department of Molecular and Cell Biology, Baylor College of Medicine, Houston, TX 77030, USA, Department of Biology and Biochemistry, University of Houston, Houston, TX 77204, USA and Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA
    Nucleic Acids Res 42:e43. 2014
    ..Of these algorithms, Bismark provides an attractive combination of processing speed, genomic coverage and quantitative accuracy, whereas Pash offers considerably higher genomic coverage. ..
  24. ncbi request reprint MGMT promoter methylation and field defect in sporadic colorectal cancer
    Lanlan Shen
    Department of Leukemia, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    J Natl Cancer Inst 97:1330-8. 2005
    ..The DNA repair gene O6-methylguanine-DNA methyltransferase (MGMT) is frequently methylated in colorectal cancer. We hypothesized that MGMT methylation could be one of the mediators of field cancerization in the colon mucosa...
  25. pmc Widespread and tissue specific age-related DNA methylation changes in mice
    Shinji Maegawa
    Department of Leukemia, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Genome Res 20:332-40. 2010
    ..We conclude that epigenetic deregulation is a common feature of aging in mammals...
  26. ncbi request reprint Hypomethylation of long interspersed nuclear element-1 in hepatocellular carcinomas
    Mi Jung Kim
    Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
    Mod Pathol 22:442-9. 2009
    ..In hepatocellular carcinomas, hypermethylation of CpG islands, and CpG island methylator phenotype status seems to correlate with levels of long interspersed nuclear element-1 hypomethylation...
  27. pmc Chromatin immunoprecipitation microarrays for identification of genes silenced by histone H3 lysine 9 methylation
    Yutaka Kondo
    Department of Leukemia, University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Proc Natl Acad Sci U S A 101:7398-403. 2004
    ..This unbiased approach confirms the tight coupling between DNA methylation and histone modifications in cancer and could be used to probe gene silencing in nonneoplastic conditions as well...
  28. pmc Induction of hypomethylation and molecular response after decitabine therapy in patients with chronic myelomonocytic leukemia
    Yasuhiro Oki
    Department of Leukemia, University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Blood 111:2382-4. 2008
    ..Our data suggest a predominantly noncytotoxic mechanism of action for decitabine, leading to altered biology of the neoplastic clone and/or normal cells. This trial was registered at www.ClinicalTrials.gov as #NCT00067808...
  29. pmc Developmentally programmed 3' CpG island methylation confers tissue- and cell-type-specific transcriptional activation
    Da Hai Yu
    Department of Pediatrics, Baylor College of Medicine, USDA ARS Children s Nutrition Research Center, Houston, Texas, USA
    Mol Cell Biol 33:1845-58. 2013
    ..These findings expand the classic view of mammalian CGI methylation as a mechanism for transcriptional silencing and indicate a functional role for 3' CGI methylation in developmental gene regulation...
  30. pmc Repetitive elements and enforced transcriptional repression co-operate to enhance DNA methylation spreading into a promoter CpG-island
    Yan Zhang
    Department of Leukemia, The University of Texas MD Anderson Cancer Center, The University of Texas Health Science Center at Houston, Houston, TX 77030, USA
    Nucleic Acids Res 40:7257-68. 2012
    ....
  31. ncbi request reprint Silencing of bidirectional promoters by DNA methylation in tumorigenesis
    Jingmin Shu
    Department of Leukemia, M D Anderson Cancer Center, Houston, Texas 77030, USA
    Cancer Res 66:5077-84. 2006
    ....
  32. pmc Frequent alteration of MLL3 frameshift mutations in microsatellite deficient colorectal cancer
    Yoshiyuki Watanabe
    Department of Leukemia, The University of Texas M D Anderson Cancer Center, Houston, Texas, United States of America
    PLoS ONE 6:e23320. 2011
    ..Mutations in MLL3 were found in a whole genome analysis of colorectal cancer but have not been confirmed by a separate study...
  33. ncbi request reprint Aberrant DNA methylation of p57KIP2 identifies a cell-cycle regulatory pathway with prognostic impact in adult acute lymphocytic leukemia
    Lanlan Shen
    Department of Leukemia, University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Blood 101:4131-6. 2003
    ..02). Our results indicate that p57KIP2 is frequently methylated in adult patients with ALL, and that inactivation of a pathway composed of p73, p15, and p57KIP2 predicts for poor prognosis in Ph-negative patients...
  34. ncbi request reprint Delta DNMT3B variants regulate DNA methylation in a promoter-specific manner
    Jie Wang
    Department of Thoracic Head and Neck Medical Oncology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Cancer Res 67:10647-52. 2007
    ..We conclude that promoter DNA methylation can be differentially regulated and DeltaDNMT3Bs are involved in regulation of such promoter-specific de novo DNA methylation...
  35. pmc 15-Lipoxygenase-1 transcriptional silencing by DNA methyltransferase-1 independently of DNA methylation
    Xiangsheng Zuo
    Department of Clinical Cancer Prevention, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX 77030 4009, USA
    FASEB J 22:1981-92. 2008
    ..DNMT-1 has a direct suppressive role in 15-LOX-1 transcriptional silencing that is independent of 15-LOX-1 promoter DNA methylation...
  36. pmc Correlation between CpG methylation profiles and hormone receptor status in breast cancers
    Weiwei Feng
    Department of Experimental Therapeutics, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX 77030, USA
    Breast Cancer Res 9:R57. 2007
    ..The present study was undertaken to determine whether methylation of a set of growth-suppressor genes would correlate to the expression of estrogen receptors (ERs) and progesterone receptors (PRs)...
  37. ncbi request reprint Age-related DNA methylation changes in normal human prostate tissues
    Bernard Kwabi-Addo
    Department of Pathology, Baylor College of Medicine, The University of Texas M D Anderson Cancer Center, Houston, Texas, USA
    Clin Cancer Res 13:3796-802. 2007
    ..We examined the extent of gene methylation in pathologically normal human prostate as a function of age...
  38. pmc Critical role of histone methylation in tumor suppressor gene silencing in colorectal cancer
    Yutaka Kondo
    Department of Leukemia, The University of Texas M D Anderson Cancer Center, Houston 77030, USA
    Mol Cell Biol 23:206-15. 2003
    ..Our results suggest that reduced H3 Lys-4 methylation and increased H3 Lys-9 methylation play a critical role in the maintenance of promoter DNA methylation-associated gene silencing in colorectal cancer...
  39. ncbi request reprint Phenotype of microsatellite-stable colorectal carcinomas with CpG island methylation
    Lucian R Chirieac
    Department of Pathology, Division of Pathology and Laboratory Medicine, University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Am J Surg Pathol 29:429-36. 2005
    ..5, P = 0.03). Our epigenotype-phenotype correlation study shows that microsatellite-stable CRC with CpG island methylation have a distinctive pathologic phenotype with both similarities to and differences from MSI-H tumors...
  40. pmc Season of conception in rural gambia affects DNA methylation at putative human metastable epialleles
    Robert A Waterland
    Department of Pediatrics, Baylor College of Medicine, USDA ARS Children s Nutrition Research Center, Houston, Texas, United States of America
    PLoS Genet 6:e1001252. 2010
    ..MEs should therefore facilitate an improved understanding of the role of interindividual epigenetic variation in human disease...
  41. ncbi request reprint Methods of DNA methylation analysis
    Lanlan Shen
    Department of Leukemia, University of Texas MD Anderson Cancer Center, USA
    Curr Opin Clin Nutr Metab Care 10:576-81. 2007
    ..To provide guidance for investigators who are new to the field of DNA methylation analysis...
  42. pmc Effects of TET2 mutations on DNA methylation in chronic myelomonocytic leukemia
    Jumpei Yamazaki
    Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX, USA
    Epigenetics 7:201-7. 2012
    ..0% and 9.8%, respectively) (p = 0.016). Thus, TET2 mutations affect global methylation in CMML but most of the changes are likely to be outside gene promoters...
  43. pmc Epigenomic profiling indicates a role for DNA methylation in early postnatal liver development
    Robert A Waterland
    Department of Pediatrics, Baylor College of Medicine, USDA Children s Nutrition Research Center, 1100 Bates St, Ste 5080, Houston, TX 77030, USA
    Hum Mol Genet 18:3026-38. 2009
    ..These in vivo data clearly indicate a role for DNA methylation in mammalian differentiation, and provide the novel insight that critical windows in mammalian developmental epigenetics extend well beyond early embryonic development...
  44. ncbi request reprint P14 methylation in human colon cancer is associated with microsatellite instability and wild-type p53
    Lanlan Shen
    Department of Leukemia, The University of Texas at M D Anderson Cancer Center, Houston, Texas 77030, USA
    Gastroenterology 124:626-33. 2003
    ..The p14 (ARF) gene on chromosome 9p is deleted and/or silenced by hypermethylation in a subset of human malignancies. There is evidence suggesting that p14 suppresses tumorigenicity by stabilizing the p53 protein...
  45. pmc Foxa1 functions as a pioneer transcription factor at transposable elements to activate Afp during differentiation of embryonic stem cells
    Joseph H Taube
    Department of Biochemistry and Molecular Biology, Graduate School of Biomedical Sciences, Center for Stem Cell and Developmental Biology, University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA
    J Biol Chem 285:16135-44. 2010
    ....
  46. ncbi request reprint DNA methylation and environmental exposures in human hepatocellular carcinoma
    Lanlan Shen
    Department of Leukemia, The University of Texas M D Anderson Cancer Center, Houston, 77030, USA
    J Natl Cancer Inst 94:755-61. 2002
    ..To determine whether CIMP is associated with the development of hepatocellular carcinoma (HCC) and with exposure to environmental agents, we examined the methylation status of CpG islands in HCCs from countries with various HCC risks...
  47. ncbi request reprint Decitabine improves patient outcomes in myelodysplastic syndromes: results of a phase III randomized study
    Hagop Kantarjian
    Department of Leukemia, University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Cancer 106:1794-803. 2006
    ..Decitabine indirectly depletes methylcytosine and causes hypomethylation of target gene promoters...
  48. ncbi request reprint Vascular endothelial growth factor receptor-1 activation mediates epithelial to mesenchymal transition in human pancreatic carcinoma cells
    Anthony D Yang
    Department of Surgical Oncology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77230 1402, USA
    Cancer Res 66:46-51. 2006
    ..Given our previous finding of VEGFR-1-mediated tumor cell invasion and migration in pancreatic carcinoma cells, we hypothesize that VEGFR-1 plays a role in tumor progression in pancreatic cancer through the induction of EMT...
  49. pmc Understanding the development of human bladder cancer by using a whole-organ genomic mapping strategy
    Tadeusz Majewski
    Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
    Lab Invest 88:694-721. 2008
    ..These analyses provided new insights on the involvement of several non-coding sequences mapping to the region and identified novel target genes, termed forerunner (FR) genes, involved in early phases of cancer development...
  50. pmc Forerunner genes contiguous to RB1 contribute to the development of in situ neoplasia
    Sangkyou Lee
    Department of Pathology, University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
    Proc Natl Acad Sci U S A 104:13732-7. 2007
    ..We also show that homozygous inactivation of P2RY5 was antecedent to the loss of RB1 during tumor development, and that nucleotide substitutions in P2RY5 represent a cancer predisposing factor...
  51. pmc HLTF gene silencing in human colon cancer
    Helen R Moinova
    Cancer Center and Department of Medicine at Case Western Reserve University, Cleveland, OH 44106, USA
    Proc Natl Acad Sci U S A 99:4562-7. 2002
    ..These findings show that HLTF is a common target for methylation and epigenetic gene silencing in colon cancer and suggest HLTF is a candidate colon cancer suppressor gene...
  52. doi request reprint Variable DNA methylation patterns associated with progression of disease in hepatocellular carcinomas
    Wentao Gao
    Division of Molecular Oncology, Aichi Cancer Center Research Institute, 1 1 Kanokoden, Chikusa ku, Nagoya 464 8681, Japan
    Carcinogenesis 29:1901-10. 2008
    ..Our global epigenome analysis reveals distinct patterns of methylation that are probably to represent different pathophysiologic processes in HCCs...
  53. ncbi request reprint Epigenetic inactivation of EGFR by CpG island hypermethylation in cancer
    Alberto J Montero
    Division of Hematology Oncology, Medical University of South Carolina, Charleston, South Carolina, USA
    Cancer Biol Ther 5:1494-501. 2006
    ..In conclusion, EGFR is hypermethylated and silenced in a subset of solid tumor cell lines and primary tumor specimens, and cotreatment with decitabine and gefitinib has an additive effect only in EGFR methylated breast cancer cell lines...
  54. pmc Downregulation of histone H3 lysine 9 methyltransferase G9a induces centrosome disruption and chromosome instability in cancer cells
    Yutaka Kondo
    Division of Molecular Oncology, Aichi Cancer Center Research Institute, Nagoya, Japan
    PLoS ONE 3:e2037. 2008
    ..Cancer cells are characterized by prominent epigenetic dysregulation, including histone modifications. However, the functional roles of the histone methyltransferases (HMT) in cancer remain unclear...
  55. ncbi request reprint Lack of p21(CIP1) DNA methylation in acute lymphocytic leukemia
    Lanlan Shen
    Blood 100:3432-3; author reply 3433-4. 2002
  56. ncbi request reprint CIMP, at last
    Jean Pierre J Issa
    Gastroenterology 129:1121-4. 2005