REUBEN JAMES SHAW

Summary

Affiliation: The Salk Institute
Country: USA

Publications

  1. ncbi request reprint DNA damage-induced association of ATM with its target proteins requires a protein interaction domain in the N terminus of ATM
    Norvin Fernandes
    Department of Radiation Oncology, Harvard Medical School, Dana Farber Cancer Institute, Boston, Massachusetts 02115, USA
    J Biol Chem 280:15158-64. 2005
  2. pmc Raptor is phosphorylated by cdc2 during mitosis
    Dana M Gwinn
    Molecular and Cell Biology Laboratory, Dulbecco Center for Cancer Research, La Jolla, California, United States of America
    PLoS ONE 5:e9197. 2010
  3. pmc Metabolism and cancer mix in Madrid
    Reuben J Shaw
    Dulbecco Center for Cancer Research, Howard Hughes Medical Institute and Salk Institute for Biological Studies, La Jolla, California, USA
    EMBO Rep 11:249-51. 2010
  4. doi request reprint Tumor suppression by LKB1: SIK-ness prevents metastasis
    Reuben J Shaw
    Molecular and Cell Biology Laboratory, The Salk Institute for Biological Studies, La Jolla, CA 92037, USA
    Sci Signal 2:pe55. 2009
  5. pmc LKB1 and AMP-activated protein kinase control of mTOR signalling and growth
    R J Shaw
    Molecular and Cell Biology Laboratory, The Salk Institute for Biological Studies, La Jolla, CA 92037, USA
    Acta Physiol (Oxf) 196:65-80. 2009
  6. ncbi request reprint Raptor swoops in on metabolism
    Reuben J Shaw
    Molecular and Cell Biology Laboratory, The Salk Institute for Biological Studies, La Jolla, CA 92037, USA
    Cell Metab 8:343-4. 2008
  7. pmc LKB1: cancer, polarity, metabolism, and now fertility
    Reuben J Shaw
    Dulbecco Center for Cancer Research, Molecular and Cell Biology Laboratory, The Salk Institute for Biological Studies, La Jolla, CA 92037, USA
    Biochem J 416:e1-3. 2008
  8. pmc mTOR signaling: RAG GTPases transmit the amino acid signal
    Reuben J Shaw
    Molecular and Cell Biology Laboratory, The Salk Institute for Biological Studies, La Jolla, CA 92037, USA
    Trends Biochem Sci 33:565-8. 2008
  9. ncbi request reprint Glucose metabolism and cancer
    Reuben J Shaw
    Dulbecco Center for Cancer Research, The Salk Institute for Biological Studies, La Jolla, CA 92037, USA
    Curr Opin Cell Biol 18:598-608. 2006
  10. pmc The kinase LKB1 mediates glucose homeostasis in liver and therapeutic effects of metformin
    Reuben J Shaw
    Department of Systems Biology, Harvard Medical School, Boston, MA 02115, USA
    Science 310:1642-6. 2005

Collaborators

Detail Information

Publications23

  1. ncbi request reprint DNA damage-induced association of ATM with its target proteins requires a protein interaction domain in the N terminus of ATM
    Norvin Fernandes
    Department of Radiation Oncology, Harvard Medical School, Dana Farber Cancer Institute, Boston, Massachusetts 02115, USA
    J Biol Chem 280:15158-64. 2005
    ..Furthermore, this domain of ATM is required for ATM to form nuclear foci following exposure to ionizing radiation...
  2. pmc Raptor is phosphorylated by cdc2 during mitosis
    Dana M Gwinn
    Molecular and Cell Biology Laboratory, Dulbecco Center for Cancer Research, La Jolla, California, United States of America
    PLoS ONE 5:e9197. 2010
    ..As mTOR has been previously tied to mitotic control, we examined further how raptor may contribute to this process...
  3. pmc Metabolism and cancer mix in Madrid
    Reuben J Shaw
    Dulbecco Center for Cancer Research, Howard Hughes Medical Institute and Salk Institute for Biological Studies, La Jolla, California, USA
    EMBO Rep 11:249-51. 2010
    ..It confirmed that the outlines of the main pathways involved in coordinating nutrient uptake and metabolism with cell growth have begun to emerge...
  4. doi request reprint Tumor suppression by LKB1: SIK-ness prevents metastasis
    Reuben J Shaw
    Molecular and Cell Biology Laboratory, The Salk Institute for Biological Studies, La Jolla, CA 92037, USA
    Sci Signal 2:pe55. 2009
    ..Reduced SIK1 expression is correlated with poor prognosis in two large human breast cancer data sets. These findings suggest that SIK1 is a key upstream regulator of p53-dependent anoikis that may be targeted in tumorigenesis...
  5. pmc LKB1 and AMP-activated protein kinase control of mTOR signalling and growth
    R J Shaw
    Molecular and Cell Biology Laboratory, The Salk Institute for Biological Studies, La Jolla, CA 92037, USA
    Acta Physiol (Oxf) 196:65-80. 2009
    ..These findings have broad implications for the control of cell growth by nutrients in a number of cellular and organismal contexts...
  6. ncbi request reprint Raptor swoops in on metabolism
    Reuben J Shaw
    Molecular and Cell Biology Laboratory, The Salk Institute for Biological Studies, La Jolla, CA 92037, USA
    Cell Metab 8:343-4. 2008
    ..In this issue, two reports utilizing tissue-specific knockout mice detail key roles for mTORC1 in skeletal muscle and adipose tissue function...
  7. pmc LKB1: cancer, polarity, metabolism, and now fertility
    Reuben J Shaw
    Dulbecco Center for Cancer Research, Molecular and Cell Biology Laboratory, The Salk Institute for Biological Studies, La Jolla, CA 92037, USA
    Biochem J 416:e1-3. 2008
    ..Male mice lacking the LKB1(s) isoform have dramatic defects in spermatozoa, resulting in sterility...
  8. pmc mTOR signaling: RAG GTPases transmit the amino acid signal
    Reuben J Shaw
    Molecular and Cell Biology Laboratory, The Salk Institute for Biological Studies, La Jolla, CA 92037, USA
    Trends Biochem Sci 33:565-8. 2008
    ..Two recent complimentary studies provide compelling evidence that the Rag family of small GTPases is both necessary and sufficient to transmit a positive signal from amino acids to mTOR...
  9. ncbi request reprint Glucose metabolism and cancer
    Reuben J Shaw
    Dulbecco Center for Cancer Research, The Salk Institute for Biological Studies, La Jolla, CA 92037, USA
    Curr Opin Cell Biol 18:598-608. 2006
    ..Several promising therapeutic strategies based on modulation of AMPK, HIF and other metabolic targets have been proposed to exploit the addiction of tumor cells to increased glucose uptake and glycolysis...
  10. pmc The kinase LKB1 mediates glucose homeostasis in liver and therapeutic effects of metformin
    Reuben J Shaw
    Department of Systems Biology, Harvard Medical School, Boston, MA 02115, USA
    Science 310:1642-6. 2005
    ..Finally, we show that metformin, one of the most widely prescribed type 2 diabetes therapeutics, requires LKB1 in the liver to lower blood glucose levels...
  11. ncbi request reprint Ras, PI(3)K and mTOR signalling controls tumour cell growth
    Reuben J Shaw
    Dulbecco Laboratory for Cancer Research, The Salk Institute, 10010 N Torrey Pines Road, La Jolla, California 9203, USA
    Nature 441:424-30. 2006
    ..The preponderance of mutations in these interconnected pathways suggests that the loss of growth-control checkpoints and promotion of cell survival in nutrient-limited conditions may be an obligate event in tumorigenesis...
  12. pmc The tumor suppressor LKB1 kinase directly activates AMP-activated kinase and regulates apoptosis in response to energy stress
    Reuben J Shaw
    Department of Systems Biology, Harvard Medical School, and Division of Signal Transduction, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
    Proc Natl Acad Sci U S A 101:3329-35. 2004
    ..The role of LKB1/AMPK in the survival of a subset of genetically defined tumor cells may provide opportunities for cancer therapeutics...
  13. pmc Cardiac-specific deletion of LKB1 leads to hypertrophy and dysfunction
    Yasumasa Ikeda
    Molecular Cardiology Whitaker Cardiovascular Institute, Boston University School of Medicine, Boston, Massachusetts 02118, USA
    J Biol Chem 284:35839-49. 2009
    ..Cardiac hypertrophy and dysfunction in LKB1-deficient hearts are associated with alterations in AMPK and mTOR/p70S6 kinase/eEF2 signaling and with a reduction in vascular endothelial growth factor expression and vessel rarefaction...
  14. pmc mTOR and HIF-1alpha-mediated tumor metabolism in an LKB1 mouse model of Peutz-Jeghers syndrome
    David B Shackelford
    Dulbecco Center for Cancer Research, The Salk Institute for Biological Studies, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 106:11137-42. 2009
    ..These findings suggest a number of therapeutic modalities for the treatment and detection of hamartomas in PJS patients, and potential for the screening and treatment of the 30% of sporadic human lung cancers bearing LKB1 mutations...
  15. ncbi request reprint The LKB1 tumor suppressor negatively regulates mTOR signaling
    Reuben J Shaw
    Department of Systems Biology, Harvard Medical School and Division of Signal Transduction, Beth Israel Deaconess Medical Center, Boston, Massachusetts 02115, USA
    Cancer Cell 6:91-9. 2004
    ..These findings position aberrant mTOR activation at the nexus of these germline neoplastic conditions and suggest the use of mTOR inhibitors in the treatment of Peutz-Jeghers syndrome...
  16. pmc The LKB1-AMPK pathway: metabolism and growth control in tumour suppression
    David B Shackelford
    Dulbecco Center for Cancer Research, Molecular and Cell Biology Laboratory, The Salk Institute for Biological Studies, La Jolla, California 92037, USA
    Nat Rev Cancer 9:563-75. 2009
    ..The connection of AMPK with several tumour suppressors suggests that therapeutic manipulation of this pathway using established diabetes drugs warrants further investigation in patients with cancer...
  17. pmc AMPK regulates the circadian clock by cryptochrome phosphorylation and degradation
    Katja A Lamia
    Gene Expression Laboratory, The Salk Institute, La Jolla, CA 92037, USA
    Science 326:437-40. 2009
    ..Thus, phosphorylation by AMPK enables cryptochrome to transduce nutrient signals to circadian clocks in mammalian peripheral organs...
  18. pmc AMPK phosphorylation of raptor mediates a metabolic checkpoint
    Dana M Gwinn
    Molecular and Cell Biology Laboratory, Dulbecco Center for Cancer Research, Salk Institute for Biological Studies, La Jolla, CA 92037, USA
    Mol Cell 30:214-26. 2008
    ..These findings uncover a conserved effector of AMPK that mediates its role as a metabolic checkpoint coordinating cell growth with energy status...
  19. ncbi request reprint Resveratrol improves health and survival of mice on a high-calorie diet
    Joseph A Baur
    Department of Pathology, Paul F Glenn Laboratories for the Biological Mechanisms of Aging, Harvard Medical School, 77 Avenue Louis Pasteur, Boston, Massachusetts 02115, USA
    Nature 444:337-42. 2006
    ..These data show that improving general health in mammals using small molecules is an attainable goal, and point to new approaches for treating obesity-related disorders and diseases of ageing...
  20. pmc AMPK and PPARdelta agonists are exercise mimetics
    Vihang A Narkar
    Gene Expression Laboratory, Salk Institute, La Jolla, CA 92037, USA
    Cell 134:405-15. 2008
    ..These results demonstrate that AMPK-PPARdelta pathway can be targeted by orally active drugs to enhance training adaptation or even to increase endurance without exercise...
  21. pmc LKB1 deficiency in Tie2-Cre-expressing cells impairs ischemia-induced angiogenesis
    Koji Ohashi
    Molecular Cardiology Whitaker Cardiovascular Institute, Boston University School of Medicine, Boston, Massachusetts 02118, USA
    J Biol Chem 285:22291-8. 2010
    ..These observations suggest that the LKB1-AMPK signaling axis in endothelial cells is a positive regulator of the revascularization response to tissue ischemia...
  22. pmc Optimizing dietary restriction for genetic epistasis analysis and gene discovery in C. elegans
    William Mair
    Molecular and Cell Biology Laboratory, The Salk Institute for Biological Studies, La Jolla, California, United States of America
    PLoS ONE 4:e4535. 2009
    ..1, highlighting the importance of first optimizing DR to identify universal regulators of DR mediated longevity...

Research Grants4

  1. Role of LKB1 and AMPK in Metformin and TZD Control of Glucose Metabolism in Liver
    REUBEN SHAW; Fiscal Year: 2007
    ..These studies will better illuminate the mechanism of action of these two widely used type 2 diabetes modalities, as well as identifying many new targets for the development of future therapeutics. ..
  2. Role of LKB1 and AMPK in Metformin and TZD Control of Glucose Metabolism in Liver
    REUBEN SHAW; Fiscal Year: 2009
    ..These studies will better illuminate the mechanism of action of these two widely used type 2 diabetes modalities, as well as identifying many new targets for the development of future therapeutics. ..
  3. Role of LKB1 and AMPK in Metformin and TZD Control of Glucose Metabolism in Liver
    REUBEN JAMES SHAW; Fiscal Year: 2010
    ..These studies will better illuminate the mechanism of action of these two widely used type 2 diabetes modalities, as well as identifying many new targets for the development of future therapeutics. ..