Sheela Sharma

Summary

Affiliation: The Hamner Institutes for Health Sciences
Country: USA

Publications

  1. ncbi request reprint Quantitative morphometry of respiratory tract epithelial cells as a tool for testing chemopreventive agent efficacy
    Sheela Sharma
    Division of Toxicology and Preclinical Studies, The Hamner Institutes for Health Sciences, P O Box 12137, Research Triangle Park, NC 27709, USA
    Anticancer Res 30:737-42. 2010
  2. pmc Chemopreventive efficacy and mechanism of licofelone in a mouse lung tumor model via aspiration
    Sheela Sharma
    Center for Preclinical Safety and Efficacy, The Hamner Institutes for Health Sciences, Six Davis Drive, Research Triangle Park, NC 27709, USA
    Cancer Prev Res (Phila) 4:1233-42. 2011
  3. doi request reprint Toxicity profile of solvents by aspiration approach for topical agent delivery to respiratory tract epithelium
    Sheela Sharma
    Division of Toxicology and Preclinical Studies, The Hamner Institutes for Health Sciences, Research Triangle Park, NC 27709, USA
    Int J Toxicol 30:358-66. 2011
  4. pmc Differential activity of NO synthase inhibitors as chemopreventive agents in a primary rat tracheal epithelial cell transformation system
    Sheela Sharma
    Cellular and Molecular Toxicology Program, ManTech Environmental Technology, Inc, Research Triangle Park, NC 27709, USA
    Neoplasia 4:332-6. 2002
  5. ncbi request reprint The chemopreventive efficacy of inhaled oltipraz particulates in the B[a]P-induced A/J mouse lung adenoma model
    Sheela Sharma
    Cellular and Molecular Toxicology Program, Alion Life and Environmental Sciences, Research Triangle Park, NC 27709, USA
    Carcinogenesis 27:1721-7. 2006
  6. doi request reprint Genotoxicity of intermittent co-exposure to benzene and toluene in male CD-1 mice
    Barbara A Wetmore
    The Hamner Institutes for Health Sciences, 6 Davis Drive, PO Box 12137, Research Triangle Park, NC 27709 2137, USA
    Chem Biol Interact 173:166-78. 2008

Detail Information

Publications6

  1. ncbi request reprint Quantitative morphometry of respiratory tract epithelial cells as a tool for testing chemopreventive agent efficacy
    Sheela Sharma
    Division of Toxicology and Preclinical Studies, The Hamner Institutes for Health Sciences, P O Box 12137, Research Triangle Park, NC 27709, USA
    Anticancer Res 30:737-42. 2010
    ..As there is strong correlation between the FIA and morphometry data, morphometry analysis is useful for rapid screening of potential chemopreventive agents...
  2. pmc Chemopreventive efficacy and mechanism of licofelone in a mouse lung tumor model via aspiration
    Sheela Sharma
    Center for Preclinical Safety and Efficacy, The Hamner Institutes for Health Sciences, Six Davis Drive, Research Triangle Park, NC 27709, USA
    Cancer Prev Res (Phila) 4:1233-42. 2011
    ..This is the first study to show that the aspiration route can be an excellent inexpensive alternative to inhalation for direct delivery of drugs to rodent lungs for efficacy testing of potential chemopreventive agents...
  3. doi request reprint Toxicity profile of solvents by aspiration approach for topical agent delivery to respiratory tract epithelium
    Sheela Sharma
    Division of Toxicology and Preclinical Studies, The Hamner Institutes for Health Sciences, Research Triangle Park, NC 27709, USA
    Int J Toxicol 30:358-66. 2011
    ..1% and 2% PEG-400, and 1% labrasol by longer dosing. All solvents except for 10% ethanol and 2% PEG-400 are suitable for agent aspiration...
  4. pmc Differential activity of NO synthase inhibitors as chemopreventive agents in a primary rat tracheal epithelial cell transformation system
    Sheela Sharma
    Cellular and Molecular Toxicology Program, ManTech Environmental Technology, Inc, Research Triangle Park, NC 27709, USA
    Neoplasia 4:332-6. 2002
    ..The data from this study identify NOS inhibitors as a novel class of chemopreventive agents that can be developed for lung cancer prevention...
  5. ncbi request reprint The chemopreventive efficacy of inhaled oltipraz particulates in the B[a]P-induced A/J mouse lung adenoma model
    Sheela Sharma
    Cellular and Molecular Toxicology Program, Alion Life and Environmental Sciences, Research Triangle Park, NC 27709, USA
    Carcinogenesis 27:1721-7. 2006
    ..The data from this study show that oltipraz is an effective agent for lung cancer prevention, when it is delivered directly to the target tissue as aerosolized particulates...
  6. doi request reprint Genotoxicity of intermittent co-exposure to benzene and toluene in male CD-1 mice
    Barbara A Wetmore
    The Hamner Institutes for Health Sciences, 6 Davis Drive, PO Box 12137, Research Triangle Park, NC 27709 2137, USA
    Chem Biol Interact 173:166-78. 2008
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