Robert E Shaddy
Affiliation: The Children's Hospital of Philadelphia
- Intermediate effects of treatment with metoprolol or carvedilol in children with left ventricular systolic dysfunctionRichard V Williams
Division of Cardiology, Department of Pediatrics, Primary Children s Medical Center and the University of Utah, Salt Lake City 84113, USA
J Heart Lung Transplant 21:906-9. 2002..When added to conventional therapy, beta-blocker therapy resulted in an increase in ejection-phase indices of left ventricular systolic performance at intermediate follow-up in pediatric patients with systolic dysfunction...
- Carvedilol for children and adolescents with heart failure: a randomized controlled trialRobert E Shaddy
Department of Pediatrics, University of Utah School of Medicine and Primary Children s Medical Center, Salt Lake City, USA
JAMA 298:1171-9. 2007..Although beta-blockers improve symptoms and survival in adults with heart failure, little is known about these medications in children and adolescents...
- Applying heart failure guidelines to adult congenital heart disease patientsRobert E Shaddy
Division of Cardiology, The Children s Hospital of Philadelphia, and University of Pennsylvania School of Medicine, 34th Street and Civic Center Blvd, Philadelphia, PA 19104 4399, USA
Expert Rev Cardiovasc Ther 6:165-74. 2008..For those patients without a systemic left ventricle (e.g., a systemic right ventricle or single ventricle), there is currently no foundation for evidence-based therapy...
- Two-year reduction of panel reactive human leukocyte antigen antibodies in children receiving mycophenolate mofetil after valved allograft placementJeffrey B Anderson
Department of Pediatrics, University of North Carolina School of Medicine, North Carolina Children's Hospital, Chapel Hill, NC, USA
Transplantation 80:414-6. 2005..This study demonstrates the ability to persistently alter the HLA class I antibody response using 3 months of MMF following allograft implantation in children...
- The Pediatric Randomized Carvedilol Trial in Children with Heart Failure: rationale and designRobert E Shaddy
University of Utah Health Sciences Center, Salt Lake City, Utah, USA
Am Heart J 144:383-9. 2002..Little is known about its safety, efficacy, pharmacokinetics, and dosing profile in children...
- QT dispersion after beta-blocker therapy (carvedilol or metoprolol) in children with heart failureSusan P Etheridge
Division of Cardiology, Department of Pediatrics, University of Utah and Primary Children's Medical Center, 100 North Medical Drive, Salt Lake City, UT 84113, USA
Am J Cardiol 91:1497-500, A8. 2003
- Immunologic considerations in heart transplantation for congenital heart diseaseBeth D Kaufman
Children s Hospital of Philadelphia, Philadelphia, PA 19104 4399, USA
Curr Cardiol Rev 7:67-71. 2011....
- Allosensitization and outcomes in pediatric heart transplantationWilliam T Mahle
Department of Pediatrics, Children s Healthcare of Atlanta, Emory University School of Medicine, Atlanta, Georgia 30322, USA
J Heart Lung Transplant 30:1221-7. 2011..We sought to define the association between elevated PRA and outcomes using data from the multi-institutional Pediatric Heart Transplant Study Group...
- Panel-reactive antibodies late after allograft implantation in childrenDavid K Hooper
Department of Pediatrics, University of Utah School of Medicine and Primary Children's Medical Center, Salt Lake City, Utah 84113, USA
Ann Thorac Surg 79:641-4; discussion 645. 2005..Therefore, children who have received cryopreserved allografts before cardiac transplantation may be at greater risk for transplant rejection...
- Evidence for lack of myocardial injury in children with acute rheumatic carditisRichard V Williams
Division of Cardiology, Department of Pediatrics, Primary Children s Medical Center and the University of Utah, Salt Lake City UT 84113, USA
Cardiol Young 12:519-23. 2002..This supports the concept that acute valvar regurgitation is the major hemodynamic abnormality in these patients...
- Clinical performance of decellularized cryopreserved valved allografts compared with standard allografts in the right ventricular outflow tractPhillip T Burch
Division of Cardiothoracic Surgery, Primary Children s Medical Center and the University of Utah, Salt Lake City, Utah, USA
Ann Thorac Surg 90:1301-5; discussion 1306. 2010..To assess functional results and durability, we studied a group of patients with DCAs implanted between 2000 and 2005 and compared them with a similar group with SCAs...
- Immune response to allograft implantation in children with congenital heart defectsCammon B Arrington
University of Utah, Department of Pediatrics, Division of Pediatric Cardiology, 100 N Medical Drive, Salt Lake City, UT 84132, USA
Expert Rev Cardiovasc Ther 4:695-701. 2006..The aim of this review is to discuss the immunogenicity of cryopreserved allograft tissue and measures that may minimize the deleterious effect of the immune system on allograft function and durability...
- The impact and outcome of transplant coronary artery disease in a pediatric population: a 9-year multi-institutional studyElfriede Pahl
Children s Memorial Hospital, Department of Pediatrics, Northwestern University, Feinberg School of Medicine, Chicago, Illinois 60611, USA
J Heart Lung Transplant 24:645-51. 2005..The purpose of this study was to determine the angiographic incidence of TCAD, potential risk factors, and outcomes in a large pediatric cohort...
- Early failure of a tricuspid valve replacement with a mitral valve homograft in a heart transplant recipientRami Alharethi
Utah Transplantation Affiliated Hospitals (UTAH) Cardiac Transplant Program, LDS Hospital, Primary Children's Medical Center, Salt Lake City, Utah 84143, USA
J Heart Lung Transplant 23:1460-2. 2004..Tricuspid valve replacement was repeated with a porcine bioprosthesis with excellent recovery and function for >2 years. The mitral valve homograft displayed inflammatory features consistent with humoral immune-mediated destruction...
- The sensitized pediatric heart transplant candidate: causes, consequences, and treatment optionsRobert E Shaddy
Department of Pediatrics, University of Utah School of Medicine and Primary Children s Medical Center, Salt Lake City, UT, USA
Pediatr Transplant 9:208-14. 2005..Improved methods of diagnosing, preventing, and treating this problem can only lead to better outcomes for children who require heart transplantation...
- Ventricular remodeling in children with left ventricular dysfunction secondary to various cardiomyopathiesLloyd Y Tani
Department of Pediatrics, University of Utah School of Medicine, Salt Lake City, Utah, USA
Am J Cardiol 96:1157-61. 2005..In conclusion, LV remodeling occurs in children with LV dysfunction. The reversal of this remodeling with a decrease in the degree of MR and the size of the mitral annulus occurs as systolic function improves...
- Rheumatic fever in children younger than 5 years: is the presentation different?Lloyd Y Tani
Department of Pediatrics, University of Utah, and Primary Children s Medical Center, Salt Lake City, UT 84113, USA
Pediatrics 112:1065-8. 2003..To review our experience with children who presented with rheumatic fever (RF) before 5 years of age and to compare their presentation with that of older children...
- Outpatient management of pediatric heart failureMatthew J O'Connor
Division of Cardiology, The Children s Hospital of Philadelphia, 34th Street and Civic Center Boulevard, Philadelphia, PA 19104 4399, USA
Heart Fail Clin 6:515-29, ix. 2010..This review focuses on the current state-of-the-art with respect to the outpatient management of heart failure in children...
- Is Doppler an accurate predictor of catheterization gradients for postoperative branch pulmonary stenosis?Deborah U Frank
Department of Pediatrics, Primary Children s Medical Center and the University of Utah, Salt Lake City, USA
J Am Soc Echocardiogr 15:1140-4. 2002..These findings suggest that Doppler gradients should be interpreted cautiously in this setting...
- Spectrum of left ventricular dysfunction in potential pediatric heart transplant donorsJames J Paul
Department of Pediatrics, University of Utah, Salt Lake City, Utah 84113-1100, USA
J Heart Lung Transplant 22:548-52. 2003..To avoid wasting a valuable, limited resource, further study is needed to identify the donors suitable for pediatric heart transplantation...
- Mycophenolic mofetil reduces the HLA antibody response of children to valved allograft implantationRobert E Shaddy
Department of Pediatrics, University of Utah School of Medicine and Primary Children s Medical Center, Salt Lake City, Utah 84113, USA
Ann Thorac Surg 77:1734-9; discussion 1739. 2004..Mycophenolic mofetil (MMF) is a powerful immunosuppressant that inhibits the proliferation of both T cells and B cells and has been reported to possibly reduce HLA panel reactive antibody (PRA) in sensitized transplant recipients...
- Paediatric heart failure trials...and tribulationsRobert E Shaddy
Primary Children's Medical Center, University of Utah School of Medicine, Salt Lake City, Utah 84113, USA
Cardiol Young 17:354-5. 2007
- Wasting or obesity at time of transplant does not predict pediatric heart transplant outcomes: analysis of ISHLT pediatric heart transplant registryBeth D Kaufman
Pediatric Heart Transplant Program, Department of Pediatrics, School of Medicine, University of Pennsylvania, Division of Cardiology, Children s Hospital of Philadelphia, Philadelphia, Pennsylvania 19104 4399, USA
J Heart Lung Transplant 28:1273-8. 2009..Single-center studies identify BMI as a potential predictor of outcome after HT in children; large-scale analyses in pediatric HT have not been performed...
- Long-term, randomized comparison of balloon angioplasty and surgery for native coarctation of the aorta in childhoodCollin G Cowley
Department of Pediatrics, University of Utah and Primary Children s Medical Center, Salt Lake City, Utah, USA
Circulation 111:3453-6. 2005..A prior randomized, short-term comparison of BA and surgery for native CoA in 36 children demonstrated equivalent relief of obstruction. The risk of aneurysm formation and possibly restenosis was higher among patients treated with BA...
- Immunology and failure of valved allografts in childrenRobert E Shaddy
Department of Pediatrics, University of Utah School of Medicine, Salt Lake City, USA
Ann Thorac Surg 74:1271-5. 2002..This review presents data on the immunologic and nonimmunologic risk factors implicated in valved allograft failure, in addition to ongoing investigation into the improvement of allograft function...
- Transcatheter treatment of a large traumatic ventricular septal defectCollin G Cowley
Division of Pediatric Cardiology, University of Utah, Primary Children s Medical Center, Salt Lake City, Utah 84113, USA
Catheter Cardiovasc Interv 61:144-6. 2004..The risks of standard open heart repair using cardiopulmonary bypass were felt to be prohibitive due to coexistent injuries. This case demonstrates the feasibility of transcatheter therapy for traumatic ventricular septal defects...
- The failing Fontan: etiology, diagnosis and managementDavid J Goldberg
Division of Cardiology, The Children s Hospital of Philadelphia, 34th and Civic Center Blvd Philadelphia, PA 19104, USA
Expert Rev Cardiovasc Ther 9:785-93. 2011..In the meantime, continued development of medical therapeutics targeted at the specific problems of the Fontan circulation will be beneficial and might reduce the need for cardiac transplantation...
- Immunogenicity of decellularized cryopreserved allografts in pediatric cardiac surgery: comparison with standard cryopreserved allograftsJohn A Hawkins
Department of Pediatric Cardiothoracic Surgery, University of Utah Hospital, Salt Lake City 84113, USA
J Thorac Cardiovasc Surg 126:247-52; discussion 252-3. 2003..This preliminary study examined the HLA antibody response to these decellularized allografts and compared it with the response to standard allograft material...