Robert E Shaddy

Summary

Affiliation: The Children's Hospital of Philadelphia
Country: USA

Publications

  1. ncbi request reprint Intermediate effects of treatment with metoprolol or carvedilol in children with left ventricular systolic dysfunction
    Richard V Williams
    Division of Cardiology, Department of Pediatrics, Primary Children s Medical Center and the University of Utah, Salt Lake City 84113, USA
    J Heart Lung Transplant 21:906-9. 2002
  2. ncbi request reprint Paediatric heart failure trials...and tribulations
    Robert E Shaddy
    Primary Children s Medical Center, University of Utah School of Medicine, Salt Lake City, Utah 84113, USA
    Cardiol Young 17:354-5. 2007
  3. doi request reprint Ethics and clinical trials in congenital heart disease
    Robert E Shaddy
    Division of Pediatric Cardiology, The Children s Hospital of Philadelphia, PA 19104, USA
    World J Pediatr Congenit Heart Surg 4:50-2. 2013
  4. ncbi request reprint Carvedilol for children and adolescents with heart failure: a randomized controlled trial
    Robert E Shaddy
    Department of Pediatrics, University of Utah School of Medicine and Primary Children s Medical Center, Salt Lake City, USA
    JAMA 298:1171-9. 2007
  5. doi request reprint Applying heart failure guidelines to adult congenital heart disease patients
    Robert E Shaddy
    Division of Cardiology, The Children s Hospital of Philadelphia, and University of Pennsylvania School of Medicine, 34th Street and Civic Center Blvd, Philadelphia, PA 19104 4399, USA
    Expert Rev Cardiovasc Ther 6:165-74. 2008
  6. ncbi request reprint Two-year reduction of panel reactive human leukocyte antigen antibodies in children receiving mycophenolate mofetil after valved allograft placement
    Jeffrey B Anderson
    Department of Pediatrics, University of North Carolina School of Medicine, North Carolina Children s Hospital, Chapel Hill, NC, USA
    Transplantation 80:414-6. 2005
  7. doi request reprint BNP levels predict outcome in pediatric heart failure patients: post hoc analysis of the Pediatric Carvedilol Trial
    Scott R Auerbach
    Division of Pediatric Cardiology, Columbia University, Morgan Stanley Children s Hospital of New York Presbyterian, New York, NY, USA
    Circ Heart Fail 3:606-11. 2010
  8. ncbi request reprint The Pediatric Randomized Carvedilol Trial in Children with Heart Failure: rationale and design
    Robert E Shaddy
    University of Utah Health Sciences Center, Salt Lake City, Utah, USA
    Am Heart J 144:383-9. 2002
  9. ncbi request reprint QT dispersion after beta-blocker therapy (carvedilol or metoprolol) in children with heart failure
    Susan P Etheridge
    Division of Cardiology, Department of Pediatrics, University of Utah and Primary Children s Medical Center, 100 North Medical Drive, Salt Lake City, UT 84113, USA
    Am J Cardiol 91:1497-500, A8. 2003
  10. pmc Immunologic considerations in heart transplantation for congenital heart disease
    Beth D Kaufman
    Children s Hospital of Philadelphia, Philadelphia, PA 19104 4399, USA
    Curr Cardiol Rev 7:67-71. 2011

Detail Information

Publications33

  1. ncbi request reprint Intermediate effects of treatment with metoprolol or carvedilol in children with left ventricular systolic dysfunction
    Richard V Williams
    Division of Cardiology, Department of Pediatrics, Primary Children s Medical Center and the University of Utah, Salt Lake City 84113, USA
    J Heart Lung Transplant 21:906-9. 2002
    ..When added to conventional therapy, beta-blocker therapy resulted in an increase in ejection-phase indices of left ventricular systolic performance at intermediate follow-up in pediatric patients with systolic dysfunction...
  2. ncbi request reprint Paediatric heart failure trials...and tribulations
    Robert E Shaddy
    Primary Children s Medical Center, University of Utah School of Medicine, Salt Lake City, Utah 84113, USA
    Cardiol Young 17:354-5. 2007
  3. doi request reprint Ethics and clinical trials in congenital heart disease
    Robert E Shaddy
    Division of Pediatric Cardiology, The Children s Hospital of Philadelphia, PA 19104, USA
    World J Pediatr Congenit Heart Surg 4:50-2. 2013
    ..There is a strong need for well-designed clinical trials in congenital heart disease. Research in children, including children with congenital heart disease, must adhere to the highest ethical standards at all times. ..
  4. ncbi request reprint Carvedilol for children and adolescents with heart failure: a randomized controlled trial
    Robert E Shaddy
    Department of Pediatrics, University of Utah School of Medicine and Primary Children s Medical Center, Salt Lake City, USA
    JAMA 298:1171-9. 2007
    ..Although beta-blockers improve symptoms and survival in adults with heart failure, little is known about these medications in children and adolescents...
  5. doi request reprint Applying heart failure guidelines to adult congenital heart disease patients
    Robert E Shaddy
    Division of Cardiology, The Children s Hospital of Philadelphia, and University of Pennsylvania School of Medicine, 34th Street and Civic Center Blvd, Philadelphia, PA 19104 4399, USA
    Expert Rev Cardiovasc Ther 6:165-74. 2008
    ..For those patients without a systemic left ventricle (e.g., a systemic right ventricle or single ventricle), there is currently no foundation for evidence-based therapy...
  6. ncbi request reprint Two-year reduction of panel reactive human leukocyte antigen antibodies in children receiving mycophenolate mofetil after valved allograft placement
    Jeffrey B Anderson
    Department of Pediatrics, University of North Carolina School of Medicine, North Carolina Children s Hospital, Chapel Hill, NC, USA
    Transplantation 80:414-6. 2005
    ..This study demonstrates the ability to persistently alter the HLA class I antibody response using 3 months of MMF following allograft implantation in children...
  7. doi request reprint BNP levels predict outcome in pediatric heart failure patients: post hoc analysis of the Pediatric Carvedilol Trial
    Scott R Auerbach
    Division of Pediatric Cardiology, Columbia University, Morgan Stanley Children s Hospital of New York Presbyterian, New York, NY, USA
    Circ Heart Fail 3:606-11. 2010
    ..This study was designed to determine whether BNP levels predict outcomes in patients with moderate symptomatic HF...
  8. ncbi request reprint The Pediatric Randomized Carvedilol Trial in Children with Heart Failure: rationale and design
    Robert E Shaddy
    University of Utah Health Sciences Center, Salt Lake City, Utah, USA
    Am Heart J 144:383-9. 2002
    ..Little is known about its safety, efficacy, pharmacokinetics, and dosing profile in children...
  9. ncbi request reprint QT dispersion after beta-blocker therapy (carvedilol or metoprolol) in children with heart failure
    Susan P Etheridge
    Division of Cardiology, Department of Pediatrics, University of Utah and Primary Children s Medical Center, 100 North Medical Drive, Salt Lake City, UT 84113, USA
    Am J Cardiol 91:1497-500, A8. 2003
  10. pmc Immunologic considerations in heart transplantation for congenital heart disease
    Beth D Kaufman
    Children s Hospital of Philadelphia, Philadelphia, PA 19104 4399, USA
    Curr Cardiol Rev 7:67-71. 2011
    ....
  11. doi request reprint Allosensitization and outcomes in pediatric heart transplantation
    William T Mahle
    Department of Pediatrics, Children s Healthcare of Atlanta, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    J Heart Lung Transplant 30:1221-7. 2011
    ..We sought to define the association between elevated PRA and outcomes using data from the multi-institutional Pediatric Heart Transplant Study Group...
  12. ncbi request reprint Panel-reactive antibodies late after allograft implantation in children
    David K Hooper
    Department of Pediatrics, University of Utah School of Medicine and Primary Children s Medical Center, Salt Lake City, Utah 84113, USA
    Ann Thorac Surg 79:641-4; discussion 645. 2005
    ..The purpose of this study was to prospectively determine the level of HLA sensitization several years after implantation of cryopreserved allografts in children...
  13. doi request reprint Pediatric heart transplantation from donors with depressed ventricular function: an analysis of the United Network of Organ Sharing Database
    Joseph W Rossano
    Department of Pediatrics and Department of Surgery, The Cardiac Center, The Children s Hospital of Philadelphia, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA
    Circ Heart Fail 6:1223-9. 2013
    ..We aimed to test the hypothesis that pediatric heart transplant recipients of grafts with depressed ventricular function would have comparable survival with those with normal function...
  14. ncbi request reprint Evidence for lack of myocardial injury in children with acute rheumatic carditis
    Richard V Williams
    Division of Cardiology, Department of Pediatrics, Primary Children s Medical Center and the University of Utah, Salt Lake City UT 84113, USA
    Cardiol Young 12:519-23. 2002
    ..This supports the concept that acute valvar regurgitation is the major hemodynamic abnormality in these patients...
  15. ncbi request reprint The impact and outcome of transplant coronary artery disease in a pediatric population: a 9-year multi-institutional study
    Elfriede Pahl
    Children s Memorial Hospital, Department of Pediatrics, Northwestern University, Feinberg School of Medicine, Chicago, Illinois 60611, USA
    J Heart Lung Transplant 24:645-51. 2005
    ..The purpose of this study was to determine the angiographic incidence of TCAD, potential risk factors, and outcomes in a large pediatric cohort...
  16. doi request reprint Clinical performance of decellularized cryopreserved valved allografts compared with standard allografts in the right ventricular outflow tract
    Phillip T Burch
    Division of Cardiothoracic Surgery, Primary Children s Medical Center and the University of Utah, Salt Lake City, Utah, USA
    Ann Thorac Surg 90:1301-5; discussion 1306. 2010
    ..To assess functional results and durability, we studied a group of patients with DCAs implanted between 2000 and 2005 and compared them with a similar group with SCAs...
  17. ncbi request reprint Immune response to allograft implantation in children with congenital heart defects
    Cammon B Arrington
    University of Utah, Department of Pediatrics, Division of Pediatric Cardiology, 100 N Medical Drive, Salt Lake City, UT 84132, USA
    Expert Rev Cardiovasc Ther 4:695-701. 2006
    ..The aim of this review is to discuss the immunogenicity of cryopreserved allograft tissue and measures that may minimize the deleterious effect of the immune system on allograft function and durability...
  18. ncbi request reprint Early failure of a tricuspid valve replacement with a mitral valve homograft in a heart transplant recipient
    Rami Alharethi
    Utah Transplantation Affiliated Hospitals UTAH Cardiac Transplant Program, LDS Hospital, Primary Children s Medical Center, Salt Lake City, Utah 84143, USA
    J Heart Lung Transplant 23:1460-2. 2004
    ..Tricuspid valve replacement was repeated with a porcine bioprosthesis with excellent recovery and function for >2 years. The mitral valve homograft displayed inflammatory features consistent with humoral immune-mediated destruction...
  19. ncbi request reprint The sensitized pediatric heart transplant candidate: causes, consequences, and treatment options
    Robert E Shaddy
    Department of Pediatrics, University of Utah School of Medicine and Primary Children s Medical Center, Salt Lake City, UT, USA
    Pediatr Transplant 9:208-14. 2005
    ..Improved methods of diagnosing, preventing, and treating this problem can only lead to better outcomes for children who require heart transplantation...
  20. ncbi request reprint Rheumatic fever in children younger than 5 years: is the presentation different?
    Lloyd Y Tani
    Department of Pediatrics, University of Utah, and Primary Children s Medical Center, Salt Lake City, UT 84113, USA
    Pediatrics 112:1065-8. 2003
    ..To review our experience with children who presented with rheumatic fever (RF) before 5 years of age and to compare their presentation with that of older children...
  21. ncbi request reprint Ventricular remodeling in children with left ventricular dysfunction secondary to various cardiomyopathies
    Lloyd Y Tani
    Department of Pediatrics, University of Utah School of Medicine, Salt Lake City, Utah, USA
    Am J Cardiol 96:1157-61. 2005
    ..In conclusion, LV remodeling occurs in children with LV dysfunction. The reversal of this remodeling with a decrease in the degree of MR and the size of the mitral annulus occurs as systolic function improves...
  22. doi request reprint Persistence of anti-human leukocyte antibodies in congenital heart disease late after surgery using allografts and whole blood
    Matthew J O'Connor
    Division of Cardiology, Department of Pediatrics, University of Pennsylvania Perelman School of Medicine, Philadelphia, USA
    J Heart Lung Transplant 32:390-7. 2013
    ..Allografts are used for vascular reconstruction in many forms of congenital heart disease. Although allografts induce anti-human leukocyte antibody (HLA) formation, much about this response is unknown...
  23. doi request reprint Outpatient management of pediatric heart failure
    Matthew J O'Connor
    Division of Cardiology, The Children s Hospital of Philadelphia, 34th Street and Civic Center Boulevard, Philadelphia, PA 19104 4399, USA
    Heart Fail Clin 6:515-29, ix. 2010
    ..This review focuses on the current state-of-the-art with respect to the outpatient management of heart failure in children...
  24. ncbi request reprint Mycophenolic mofetil reduces the HLA antibody response of children to valved allograft implantation
    Robert E Shaddy
    Department of Pediatrics, University of Utah School of Medicine and Primary Children s Medical Center, Salt Lake City, Utah 84113, USA
    Ann Thorac Surg 77:1734-9; discussion 1739. 2004
    ..Mycophenolic mofetil (MMF) is a powerful immunosuppressant that inhibits the proliferation of both T cells and B cells and has been reported to possibly reduce HLA panel reactive antibody (PRA) in sensitized transplant recipients...
  25. ncbi request reprint Is Doppler an accurate predictor of catheterization gradients for postoperative branch pulmonary stenosis?
    Deborah U Frank
    Department of Pediatrics, Primary Children s Medical Center and the University of Utah, Salt Lake City, USA
    J Am Soc Echocardiogr 15:1140-4. 2002
    ..These findings suggest that Doppler gradients should be interpreted cautiously in this setting...
  26. ncbi request reprint Spectrum of left ventricular dysfunction in potential pediatric heart transplant donors
    James J Paul
    Department of Pediatrics, University of Utah, Salt Lake City, Utah 84113 1100, USA
    J Heart Lung Transplant 22:548-52. 2003
    ..Therefore, the purpose of this study was to determine the spectrum of myocardial dysfunction in potential pediatric heart transplant donors...
  27. doi request reprint Wasting or obesity at time of transplant does not predict pediatric heart transplant outcomes: analysis of ISHLT pediatric heart transplant registry
    Beth D Kaufman
    Pediatric Heart Transplant Program, Department of Pediatrics, School of Medicine, University of Pennsylvania, Division of Cardiology, Children s Hospital of Philadelphia, Philadelphia, Pennsylvania 19104 4399, USA
    J Heart Lung Transplant 28:1273-8. 2009
    ..Single-center studies identify BMI as a potential predictor of outcome after HT in children; large-scale analyses in pediatric HT have not been performed...
  28. ncbi request reprint Long-term, randomized comparison of balloon angioplasty and surgery for native coarctation of the aorta in childhood
    Collin G Cowley
    Department of Pediatrics, University of Utah and Primary Children s Medical Center, Salt Lake City, Utah, USA
    Circulation 111:3453-6. 2005
    ..A prior randomized, short-term comparison of BA and surgery for native CoA in 36 children demonstrated equivalent relief of obstruction. The risk of aneurysm formation and possibly restenosis was higher among patients treated with BA...
  29. ncbi request reprint Immunology and failure of valved allografts in children
    Robert E Shaddy
    Department of Pediatrics, University of Utah School of Medicine, Salt Lake City, USA
    Ann Thorac Surg 74:1271-5. 2002
    ..This review presents data on the immunologic and nonimmunologic risk factors implicated in valved allograft failure, in addition to ongoing investigation into the improvement of allograft function...
  30. doi request reprint Heart transplant after the Fontan operation
    Joseph W Rossano
    Department of Pediatrics, Perelman School of Medicine, The Cardiac Center, The Children s Hospital of Philadelphia, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America
    Cardiol Young 23:840-5. 2013
    ..This review will cover the indications and evaluation for heart transplantation, management of patients while waiting for heart transplantation and the current outcomes of transplantation in this population. ..
  31. doi request reprint The failing Fontan: etiology, diagnosis and management
    David J Goldberg
    Division of Cardiology, The Children s Hospital of Philadelphia, 34th and Civic Center Blvd Philadelphia, PA 19104, USA
    Expert Rev Cardiovasc Ther 9:785-93. 2011
    ..In the meantime, continued development of medical therapeutics targeted at the specific problems of the Fontan circulation will be beneficial and might reduce the need for cardiac transplantation...
  32. ncbi request reprint Transcatheter treatment of a large traumatic ventricular septal defect
    Collin G Cowley
    Division of Pediatric Cardiology, University of Utah, Primary Children s Medical Center, Salt Lake City, Utah 84113, USA
    Catheter Cardiovasc Interv 61:144-6. 2004
    ..The risks of standard open heart repair using cardiopulmonary bypass were felt to be prohibitive due to coexistent injuries. This case demonstrates the feasibility of transcatheter therapy for traumatic ventricular septal defects...
  33. ncbi request reprint Immunogenicity of decellularized cryopreserved allografts in pediatric cardiac surgery: comparison with standard cryopreserved allografts
    John A Hawkins
    Department of Pediatric Cardiothoracic Surgery, University of Utah Hospital, Salt Lake City 84113, USA
    J Thorac Cardiovasc Surg 126:247-52; discussion 252-3. 2003
    ..This preliminary study examined the HLA antibody response to these decellularized allografts and compared it with the response to standard allograft material...