Rekha Seshadri

Summary

Affiliation: The Institute for Genomic Research
Country: USA

Publications

  1. ncbi request reprint Preliminary assessment of genome differences between the reference Nine Mile isolate and two human endocarditis isolates of Coxiella burnetii
    Paul A Beare
    Coxiella Pathogenesis Section, Laboratory of Intracellular Parasites, Rocky Mountain Laboratories, NIAID, NIH, Hamilton, MT 59840, USA
    Ann N Y Acad Sci 1063:64-7. 2005
  2. ncbi request reprint Bacterial genomics and pathogen evolution
    David M Raskin
    Department of Microbiology and Molecular Genetics, Harvard Medical School, Boston, MA 02115, USA
    Cell 124:703-14. 2006
  3. ncbi request reprint Genome analysis of Coxiella burnetii species: insights into pathogenesis and evolution and implications for biodefense
    Rekha Seshadri
    The Institute for Genomic Research, Rockville, MD 20850, USA
    Ann N Y Acad Sci 1063:442-50. 2005
  4. ncbi request reprint Genome sequence of the PCE-dechlorinating bacterium Dehalococcoides ethenogenes
    Rekha Seshadri
    Institute for Genomic Research, 9712 Medical Center Drive, Rockville, MD 20850, USA
    Science 307:105-8. 2005
  5. ncbi request reprint Genome sequence of the dissimilatory metal ion-reducing bacterium Shewanella oneidensis
    John F Heidelberg
    The Institute for Genomic Research, 9712 Medical Center Drive, Rockville, MD 20850, USA
    Nat Biotechnol 20:1118-23. 2002
  6. pmc Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes
    Rekha Seshadri
    The Institute for Genomic Research, 9712 Medical Center Drive, Rockville, MD 20850, USA
    Proc Natl Acad Sci U S A 101:5646-51. 2004
  7. pmc Complete genome sequence of the Q-fever pathogen Coxiella burnetii
    Rekha Seshadri
    The Institute for Genomic Research, 9712 Medical Center Drive, Rockville, MD 20850, USA
    Proc Natl Acad Sci U S A 100:5455-60. 2003
  8. ncbi request reprint The genome sequence of the anaerobic, sulfate-reducing bacterium Desulfovibrio vulgaris Hildenborough
    John F Heidelberg
    The Institute for Genomic Research, 9712 Medical Center Drive, Rockville, Maryland 20850, USA
    Nat Biotechnol 22:554-9. 2004
  9. pmc Skewed genomic variability in strains of the toxigenic bacterial pathogen, Clostridium perfringens
    Garry S A Myers
    The Institute for Genomic Research, Rockville, Maryland 20850, USA
    Genome Res 16:1031-40. 2006
  10. ncbi request reprint Complete genome sequence of the plant commensal Pseudomonas fluorescens Pf-5
    Ian T Paulsen
    The Institute for Genomic Research, Rockville, Maryland, USA
    Nat Biotechnol 23:873-8. 2005

Collaborators

Detail Information

Publications20

  1. ncbi request reprint Preliminary assessment of genome differences between the reference Nine Mile isolate and two human endocarditis isolates of Coxiella burnetii
    Paul A Beare
    Coxiella Pathogenesis Section, Laboratory of Intracellular Parasites, Rocky Mountain Laboratories, NIAID, NIH, Hamilton, MT 59840, USA
    Ann N Y Acad Sci 1063:64-7. 2005
    ..burnetii and to provide important insight into the genome architecture and genetic diversity of this pathogen...
  2. ncbi request reprint Bacterial genomics and pathogen evolution
    David M Raskin
    Department of Microbiology and Molecular Genetics, Harvard Medical School, Boston, MA 02115, USA
    Cell 124:703-14. 2006
    ..However, a major stumbling block in the genomics revolution has been the large number of genes with unknown function that have been identified in every organism sequenced to date...
  3. ncbi request reprint Genome analysis of Coxiella burnetii species: insights into pathogenesis and evolution and implications for biodefense
    Rekha Seshadri
    The Institute for Genomic Research, Rockville, MD 20850, USA
    Ann N Y Acad Sci 1063:442-50. 2005
    ....
  4. ncbi request reprint Genome sequence of the PCE-dechlorinating bacterium Dehalococcoides ethenogenes
    Rekha Seshadri
    Institute for Genomic Research, 9712 Medical Center Drive, Rockville, MD 20850, USA
    Science 307:105-8. 2005
    ..Genome analysis provides insights into the organism's complex nutrient requirements and suggests that an ancestor was a nitrogen-fixing autotroph...
  5. ncbi request reprint Genome sequence of the dissimilatory metal ion-reducing bacterium Shewanella oneidensis
    John F Heidelberg
    The Institute for Genomic Research, 9712 Medical Center Drive, Rockville, MD 20850, USA
    Nat Biotechnol 20:1118-23. 2002
    ....
  6. pmc Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes
    Rekha Seshadri
    The Institute for Genomic Research, 9712 Medical Center Drive, Rockville, MD 20850, USA
    Proc Natl Acad Sci U S A 101:5646-51. 2004
    ....
  7. pmc Complete genome sequence of the Q-fever pathogen Coxiella burnetii
    Rekha Seshadri
    The Institute for Genomic Research, 9712 Medical Center Drive, Rockville, MD 20850, USA
    Proc Natl Acad Sci U S A 100:5455-60. 2003
    ..burnetii genome. These analyses suggest that the obligate intracellular lifestyle of C. burnetii may be a relatively recent innovation...
  8. ncbi request reprint The genome sequence of the anaerobic, sulfate-reducing bacterium Desulfovibrio vulgaris Hildenborough
    John F Heidelberg
    The Institute for Genomic Research, 9712 Medical Center Drive, Rockville, Maryland 20850, USA
    Nat Biotechnol 22:554-9. 2004
    ....
  9. pmc Skewed genomic variability in strains of the toxigenic bacterial pathogen, Clostridium perfringens
    Garry S A Myers
    The Institute for Genomic Research, Rockville, Maryland 20850, USA
    Genome Res 16:1031-40. 2006
    ....
  10. ncbi request reprint Complete genome sequence of the plant commensal Pseudomonas fluorescens Pf-5
    Ian T Paulsen
    The Institute for Genomic Research, Rockville, Maryland, USA
    Nat Biotechnol 23:873-8. 2005
    ..In addition to six known secondary metabolites produced by P. fluorescens Pf-5, three novel secondary metabolite biosynthesis gene clusters were also identified that may contribute to the biocontrol properties of P. fluorescens Pf-5...
  11. pmc Genome sequence of Aeromonas hydrophila ATCC 7966T: jack of all trades
    Rekha Seshadri
    The Institute for Genomic Research, Division of J Craig Venter Institute, Rockville, MD 20850, USA
    J Bacteriol 188:8272-82. 2006
    ..These enzymes may have bioremediative as well as industrial potential. Thus, the A. hydrophila genome sequence provides valuable insights into its ability to flourish in both aquatic and host environments...
  12. pmc Comparative genomics of emerging human ehrlichiosis agents
    Julie C Dunning Hotopp
    The Institute for Genomic Research, Rockville, Maryland, USA
    PLoS Genet 2:e21. 2006
    ..These discoveries provide significant insights into the biology of these obligate intracellular pathogens...
  13. pmc Genomic insights into methanotrophy: the complete genome sequence of Methylococcus capsulatus (Bath)
    Naomi Ward
    The Institute for Genomic Research, Rockville, Maryland, USA
    PLoS Biol 2:e303. 2004
    ..We have gained evidence for greater metabolic flexibility than was previously known, and for genetic components that may have biotechnological potential...
  14. pmc The Brucella suis genome reveals fundamental similarities between animal and plant pathogens and symbionts
    Ian T Paulsen
    The Institute for Genomic Research, 9712 Medical Center Drive, Rockville, MD 20850, USA
    Proc Natl Acad Sci U S A 99:13148-53. 2002
    ..A limited repertoire of genes homologous to known bacterial virulence factors were identified...
  15. ncbi request reprint Fur-regulated genes in Coxiella burnetii
    Heather L Briggs
    TAMUS Health Science Center, Department of Medical Microbiology and Immunology, College Station, TX 77843 1114, USA
    Ann N Y Acad Sci 1063:68-72. 2005
    ..burnetii. The results of a genomic screen for putative Fur-regulated genes and Fur boxes and the development of a two-plasmid system to analyze these Fur boxes will also be illustrated...
  16. pmc Limited role for iron regulation in Coxiella burnetii pathogenesis
    Heather L Briggs
    Department of Microbial and Molecular Pathogenesis, Texas A and M University System Health Science Center, College Station, TX 77843 1114, USA
    Infect Immun 76:2189-201. 2008
    ....
  17. pmc Identification and cloning of immunodominant antigens of Coxiella burnetii
    Guoquan Zhang
    Department of Medical Microbiology and Immunology, Texas A and M University System Health Science Center, College Station, Texas 77843 1114, USA
    Infect Immun 72:844-52. 2004
    ..These results suggest that these proteins may play critical roles in the development of protective immunity and that they are logical candidates for vaccine and serodiagnostic reagents...
  18. ncbi request reprint Sugar metabolism by Brucellae
    Richard C Essenberg
    Department of Biochemistry and Molecular Biology, 246 Noble Research Center, Oklahoma State University, Stillwater, OK 74078, USA
    Vet Microbiol 90:249-61. 2002
    ..A few questions remain, such as whether Brucella uses the Entner-Doudoroff pathway. Some of the genes in carbohydrate utilization have been shown to be important in virulence...
  19. pmc CAMERA: a community resource for metagenomics
    Rekha Seshadri
    J Craig Venter Institute, Rockville, Maryland, United States of America
    PLoS Biol 5:e75. 2007
  20. ncbi request reprint Bacteria to the rescue
    Rekha Seshadri
    Nat Biotechnol 23:1236-7. 2005