Chandan Sen

Summary

Affiliation: The Ohio State University
Country: USA

Publications

  1. pmc Transcriptome-wide analysis of blood vessels laser captured from human skin and chronic wound-edge tissue
    Sashwati Roy
    Comprehensive Wound Center, Department of Surgery, Davis Heart and Lung Research Institute, Ohio State University Medical Center, Columbus, OH 43210, USA
    Proc Natl Acad Sci U S A 104:14472-7. 2007
  2. pmc Improvement of human keratinocyte migration by a redox active bioelectric dressing
    Jaideep Banerjee
    Department of Surgery, Davis Heart and Lung Research Institute, The Ohio State University Wexner Medical Center, Columbus, Ohio, United States of America
    PLoS ONE 9:e89239. 2014
  3. pmc First evidence of sternal wound biofilm following cardiac surgery
    Haytham Elgharably
    Department of Surgery, The Ohio State University Wexner Medical Center, Columbus, Ohio, USA
    PLoS ONE 8:e70360. 2013
  4. pmc OxymiRs in cutaneous development, wound repair and regeneration
    Chandan K Sen
    Center for Regenerative Medicine and Cell Based Therapies, Comprehensive Wound Center and Davis Heart and Lung Research Institute, The Ohio State University Medical Center, Columbus, OH 43210, USA
    Semin Cell Dev Biol 23:971-80. 2012
  5. pmc Downregulation of endothelial microRNA-200b supports cutaneous wound angiogenesis by desilencing GATA binding protein 2 and vascular endothelial growth factor receptor 2
    Yuk Cheung Chan
    Department of Surgery, Davis Heart and Lung Research Institute, The Ohio State University Medical Center, Columbus, OH 43210, USA
    Arterioscler Thromb Vasc Biol 32:1372-82. 2012
  6. pmc Micromanaging vascular biology: tiny microRNAs play big band
    Chandan K Sen
    Laboratory of Molecular Medicine, Department of Surgery, Davis Heart and Lung Research Institute, Ohio State University Medical Center, Columbus, Ohio 43210, USA
    J Vasc Res 46:527-40. 2009
  7. pmc Tocotrienols in health and disease: the other half of the natural vitamin E family
    Chandan K Sen
    Laboratory of Molecular Medicine, Department of Surgery, Davis Heart and Lung Research Institute, The Ohio State University Medical Center, Columbus, OH 43210, United States
    Mol Aspects Med 28:692-728. 2007
  8. pmc Human skin wounds: a major and snowballing threat to public health and the economy
    Chandan K Sen
    Department of Surgery, The Ohio State University Comprehensive Wound Center, Columbus, Ohio 43210, USA
    Wound Repair Regen 17:763-71. 2009
  9. pmc Redox signals in wound healing
    Chandan K Sen
    Comprehensive Wound Center, Department of Surgery, Davis Heart and Lung Research Institute, The Ohio State University Medical Center, Columbus, Ohio 43210, USA
    Biochim Biophys Acta 1780:1348-61. 2008
  10. pmc Wound healing essentials: let there be oxygen
    Chandan K Sen
    The Comprehensive Wound Center, Department of Surgery and Davis Heart and Lung Research Institute, The Ohio State University Medical Center, Columbus, Ohio, USA
    Wound Repair Regen 17:1-18. 2009

Research Grants

  1. microRNA Control of Wound Healing
    Chandan K Sen; Fiscal Year: 2010
  2. Vitamin E Neuroprotection: Novel Molecular Mechanisms
    Chandan Sen; Fiscal Year: 2002
  3. Tissue oxygenation and wound angiogenesis
    Chandan Sen; Fiscal Year: 2007
  4. Oxygen Sensitive Signaling in Primary Cardiac Fibroblast
    Chandan Sen; Fiscal Year: 2006
  5. Vitamin E Neuroprotection: Novel Molecular Mechanisms
    Chandan Sen; Fiscal Year: 2009
  6. Oxygen Sensitive Signaling in Primary Cardiac Fibroblast
    Chandan Sen; Fiscal Year: 2007
  7. Redox Control of Wound Healing
    Chandan Sen; Fiscal Year: 2007
  8. Tissue oxygenation and wound angiogenesis
    Chandan K Sen; Fiscal Year: 2010
  9. Redox Control of Wound Healing
    Chandan Sen; Fiscal Year: 2005
  10. Conference--Wound Healing : O2 and Emerging Therapeutics
    Chandan Sen; Fiscal Year: 2002

Collaborators

Detail Information

Publications91

  1. pmc Transcriptome-wide analysis of blood vessels laser captured from human skin and chronic wound-edge tissue
    Sashwati Roy
    Comprehensive Wound Center, Department of Surgery, Davis Heart and Lung Research Institute, Ohio State University Medical Center, Columbus, OH 43210, USA
    Proc Natl Acad Sci U S A 104:14472-7. 2007
    ..Sets of genes with known vascular functions but never connected to wound healing were identified to be differentially expressed in wound-derived blood vessels paving the way for innovative clinically relevant hypotheses...
  2. pmc Improvement of human keratinocyte migration by a redox active bioelectric dressing
    Jaideep Banerjee
    Department of Surgery, Davis Heart and Lung Research Institute, The Ohio State University Wexner Medical Center, Columbus, Ohio, United States of America
    PLoS ONE 9:e89239. 2014
    ..Electric fields generated by a Ag/Zn BED can cross-talk with keratinocytes via redox-dependent processes improving keratinocyte migration, a critical event in wound re-epithelialization. ..
  3. pmc First evidence of sternal wound biofilm following cardiac surgery
    Haytham Elgharably
    Department of Surgery, The Ohio State University Wexner Medical Center, Columbus, Ohio, USA
    PLoS ONE 8:e70360. 2013
    ..Clinical introduction of the biofilm infection concept in deep SWI may advance the current management strategies from standard antimicrobial therapy to anti-biofilm strategy. ..
  4. pmc OxymiRs in cutaneous development, wound repair and regeneration
    Chandan K Sen
    Center for Regenerative Medicine and Cell Based Therapies, Comprehensive Wound Center and Davis Heart and Lung Research Institute, The Ohio State University Medical Center, Columbus, OH 43210, USA
    Semin Cell Dev Biol 23:971-80. 2012
    ..This emerging paradigm has major implications in untangling the complexities underlying diseases associated with ischemia and related hypoxic insult such as chronic wounds...
  5. pmc Downregulation of endothelial microRNA-200b supports cutaneous wound angiogenesis by desilencing GATA binding protein 2 and vascular endothelial growth factor receptor 2
    Yuk Cheung Chan
    Department of Surgery, Davis Heart and Lung Research Institute, The Ohio State University Medical Center, Columbus, OH 43210, USA
    Arterioscler Thromb Vasc Biol 32:1372-82. 2012
    ..MicroRNAs (miRs) regulate angiogenesis by posttranscriptional silencing of target genes. The significance of angiostatic miR-200b in switching on skin wound angiogenesis was tested...
  6. pmc Micromanaging vascular biology: tiny microRNAs play big band
    Chandan K Sen
    Laboratory of Molecular Medicine, Department of Surgery, Davis Heart and Lung Research Institute, Ohio State University Medical Center, Columbus, Ohio 43210, USA
    J Vasc Res 46:527-40. 2009
    ..Prudent targeting of non-coding genes such as miRNAs, which in turn regulates large sets of coding genes, holds promise in gene therapy. Recent developments in miRNA biology offer lucrative opportunities to manage vascular health...
  7. pmc Tocotrienols in health and disease: the other half of the natural vitamin E family
    Chandan K Sen
    Laboratory of Molecular Medicine, Department of Surgery, Davis Heart and Lung Research Institute, The Ohio State University Medical Center, Columbus, OH 43210, United States
    Mol Aspects Med 28:692-728. 2007
    ..The current state of knowledge warrants strategic investment into investigating the lesser known forms of vitamin E...
  8. pmc Human skin wounds: a major and snowballing threat to public health and the economy
    Chandan K Sen
    Department of Surgery, The Ohio State University Comprehensive Wound Center, Columbus, Ohio 43210, USA
    Wound Repair Regen 17:763-71. 2009
    ..The immense economic and social impact of wounds in our society calls for allocation of a higher level of attention and resources to understand biological mechanisms underlying cutaneous wound complications...
  9. pmc Redox signals in wound healing
    Chandan K Sen
    Comprehensive Wound Center, Department of Surgery, Davis Heart and Lung Research Institute, The Ohio State University Medical Center, Columbus, Ohio 43210, USA
    Biochim Biophys Acta 1780:1348-61. 2008
    ..The objective of this review is to describe our current understanding of how redox-sensitive processes may drive dermal tissue repair...
  10. pmc Wound healing essentials: let there be oxygen
    Chandan K Sen
    The Comprehensive Wound Center, Department of Surgery and Davis Heart and Lung Research Institute, The Ohio State University Medical Center, Columbus, Ohio, USA
    Wound Repair Regen 17:1-18. 2009
    ..Oxygen dosing based on the specific need of a wound therefore seems prudent. Therapeutic approaches targeting the oxygen sensing and redox signaling pathways are promising...
  11. pmc Palm oil-derived natural vitamin E alpha-tocotrienol in brain health and disease
    Chandan K Sen
    Department of Surgery, The Ohio State University Medical Center, Columbus, Ohio, USA
    J Am Coll Nutr 29:314S-323S. 2010
    ..Despite such therapeutic potential, the scientific literature on tocotrienols accounts for roughly 1% of the total literature on vitamin E, thus warranting further investment and investigation...
  12. pmc Oxygenation state as a driver of myofibroblast differentiation and wound contraction: hypoxia impairs wound closure
    Chandan K Sen
    Comprehensive Wound Center, Davis Heart and Lung Research Institute, Department of Surgery, The Ohio State University Medical Center, Columbus, Ohio 43210, USA
    J Invest Dermatol 130:2701-3. 2010
    ..They present compelling evidence indicating tissue hypoxia conflicts with wound closure. We are reminded that correcting wound tissue hypoxia is critical for the tissue's response to other therapeutic interventions...
  13. pmc Tocotrienols: Vitamin E beyond tocopherols
    Chandan K Sen
    Department of Surgery, Davis Heart and Lung Research Institute, The Ohio State University Medical Center, Columbus, Ohio 43210, USA
    Life Sci 78:2088-98. 2006
    ..The current state of knowledge warrants strategic investment into the lesser known forms of vitamin E. This will enable prudent selection of the appropriate vitamin E molecule for studies addressing a specific need...
  14. pmc MicroRNAs as new maestro conducting the expanding symphony orchestra of regenerative and reparative medicine
    Chandan K Sen
    Davis Heart and Lung Research Institute and Comprehensive Wound Center, The Ohio State University Medical Center, Columbus, Ohio 43210, USA
    Physiol Genomics 43:517-20. 2011
    ..Treatment of skin wounds has lower barriers because it lends itself to local delivery of miRNA mimics and antagonizing agents minimizing risks associated with systemic off-target toxicity...
  15. ncbi request reprint Perceived hyperoxia: oxygen-induced remodeling of the reoxygenated heart
    Chandan K Sen
    Laboratory of Molecular Medicine, 512 Davis Heart and Lung Research Institute, Department of Surgery, The Ohio State University Medical Center, 473 W 12th Avenue, Columbus, 43210, USA
    Cardiovasc Res 71:280-8. 2006
    ..Understanding of the underlying mechanisms of this and other myocardial healing responses should prove to be instrumental in developing productive therapeutic approaches to mend the infarcted heart...
  16. ncbi request reprint Oxidant-induced vascular endothelial growth factor expression in human keratinocytes and cutaneous wound healing
    Chandan K Sen
    Laboratory of Molecular Medicine, Dorothy M Davis Heart and Lung Research Institute, Department of Surgery Center for Minimally Invasive Surgery, The Ohio State University Medical Center, Columbus, Ohio 43210, USA
    J Biol Chem 277:33284-90. 2002
    ..Taken together, the results of this study indicate that wound healing is subject to redox control...
  17. ncbi request reprint Dermal wound healing properties of redox-active grape seed proanthocyanidins
    Savita Khanna
    Department of Surgery, Heart and Lung Research Institute, The Ohio State University Medical Center, Columbus, OH 43210, USA
    Free Radic Biol Med 33:1089-96. 2002
    ..In summary, our current study provides firm evidence to support that topical application of GSPE represents a feasible and productive approach to support dermal wound healing...
  18. pmc Fra-2 mediates oxygen-sensitive induction of transforming growth factor beta in cardiac fibroblasts
    Sashwati Roy
    Department of Surgery, The Ohio State University Medical Center, 513 Davis Heart and Lung Research Institute, 473 West 12th Avenue, Columbus, OH 43210, USA
    Cardiovasc Res 87:647-55. 2010
    ....
  19. ncbi request reprint Oxygen: from the benefits of inducing VEGF expression to managing the risk of hyperbaric stress
    Viren Patel
    Laboratory of Molecular Medicine, Department of Surgery, The Ohio State University Medical Center, Columbus, OH 43210, USA
    Antioxid Redox Signal 7:1377-87. 2005
    ..This is of special concern for people with inadequate intake of dietary antioxidants. Nutritional antioxidant supplementation may offset HBO-induced oxidative stress...
  20. ncbi request reprint Anti-angiogenic property of edible berries
    Sashwati Roy
    Laboratory of Molecular Medicine, Department of Surgery, 512 Heart and Lung Research Institute, Ohio State University Medical Center, 473 W 12th Avenue, Columbus, OH 43210, USA
    Free Radic Res 36:1023-31. 2002
    ..Matrigel assay using human dermal microvascular endothelial cells showed that edible berries impair angiogenesis...
  21. pmc A mathematical model of ischemic cutaneous wounds
    Chuan Xue
    Mathematical Biosciences Institute and Department of Mathematics, Ohio State University, Columbus, OH 43210, USA
    Proc Natl Acad Sci U S A 106:16782-7. 2009
    ..Simulations of the model demonstrate how ischemic conditions may limit macrophage recruitment to the wound-site and impair wound closure. The results are in general agreement with experimental findings...
  22. ncbi request reprint Copper-induced vascular endothelial growth factor expression and wound healing
    Chandan K Sen
    Laboratory of Molecular Medicine, Department of Surgery, 512 Davis Heart and Lung Research Institute, The Ohio State University Medical Center, Columbus, Ohio 43210, USA
    Am J Physiol Heart Circ Physiol 282:H1821-7. 2002
    ..Copper-sensitive pathways regulate key mediators of wound healing such as angiogenesis and extracellular matrix remodeling. Copper-based therapeutics represents a feasible approach to promote dermal wound healing...
  23. ncbi request reprint Evidence for the involvement of miRNA in redox regulated angiogenic response of human microvascular endothelial cells
    Shani Shilo
    Comprehensive Wound Center, Department of Surgery, The Ohio State University Medical Center, Columbus, Ohio 43210, USA
    Arterioscler Thromb Vasc Biol 28:471-7. 2008
    ..A Dicer knockdown approach was used to test the significance of miRNA in regulating the redox state and angiogenic response of human microvascular endothelial cells (HMECs)...
  24. pmc Characterization of a preclinical model of chronic ischemic wound
    Sashwati Roy
    Comprehensive Wound Center, Davis Heart and Lung Research Institute, Department of Surgery, The Ohio State University Medical Center, Columbus, Ohio 43210, USA
    Physiol Genomics 37:211-24. 2009
    ..This study provides a thorough database that may serve as a valuable reference tool to develop novel hypotheses aiming to elucidate the biology of ischemic chronic wounds in a preclinical setting...
  25. ncbi request reprint Laser microdissection and capture of pure cardiomyocytes and fibroblasts from infarcted heart regions: perceived hyperoxia induces p21 in peri-infarct myocytes
    Donald E Kuhn
    Laboratory of Molecular Medicine, Department of Surgery, Davis Heart and Lung Research Institute, The Ohio State University Medical Center, Columbus, OH 43210, USA
    Am J Physiol Heart Circ Physiol 292:H1245-53. 2007
    ..This work presents the first account of an analytical technique that applies the LMPC technology to study myocardial remodeling with a cell-type specific resolution...
  26. ncbi request reprint Transcriptome of the subcutaneous adipose tissue in response to oral supplementation of type 2 Leprdb obese diabetic mice with niacin-bound chromium
    Cameron Rink
    Laboratory of Molecular Medicine, Department of Surgery, Davis Heart and Lung Research Institute, The Ohio State University Medical Center, Columbus, Ohio 43210, USA
    Physiol Genomics 27:370-9. 2006
    ..Further studies testing the molecular basis of NBC function and long-term outcomes are warranted...
  27. ncbi request reprint Transcriptome analysis of the ischemia-reperfused remodeling myocardium: temporal changes in inflammation and extracellular matrix
    Sashwati Roy
    Department of Surgery, Davis Heart and Lung Research Institute, The Ohio State University Medical Center, Columbus, Ohio, USA
    Physiol Genomics 25:364-74. 2006
    ..Taken together, this work presents the first evidence gained from the use of DNA microarrays to understand the molecular mechanisms implicated in the early and late inflammatory phases of the I-R heart...
  28. pmc Redox modification of ryanodine receptors contributes to sarcoplasmic reticulum Ca2+ leak in chronic heart failure
    Dmitry Terentyev
    Departments of Physiology and Cell Biology, College of Medicine, Ohio State University, Columbus, OH, USA
    Circ Res 103:1466-72. 2008
    ..These findings suggest that redox modification contributes to abnormal function of RyR2s in HF, presenting a potential therapeutic target for treating HF...
  29. ncbi request reprint Revisiting the essential role of oxygen in wound healing
    Gayle M Gordillo
    Department of Surgery, Laboratory of Molecular Medicine, 512 Davis Heart and Lung Research Institute, Ohio State University, 473 West 12th Ave, Columbus, OH 43210, USA
    Am J Surg 186:259-63. 2003
    ..Given that many growth factors require ROS for their function, it is reasonable to assume that approaches to correct wound pO(2) will serve as an effective adjunct in treating chronic wounds...
  30. ncbi request reprint Oxygen sensing by primary cardiac fibroblasts: a key role of p21(Waf1/Cip1/Sdi1)
    Sashwati Roy
    Laboratory of Molecular Medicine, Department of Surgery, Davis Heart and Lung Research Institute, The Ohio State University Medical Center, Columbus 43210, USA
    Circ Res 92:264-71. 2003
    ..CFs deficient in p21 were resistant to such O2 sensitivity. This study raises the vital broad-based issue of controlling ambient O2 during the culture of primary cells isolated from organs...
  31. pmc Dermal wound healing is subject to redox control
    Sashwati Roy
    Laboratory of Molecular Medicine, Department of Surgery, Comprehensive Wound Center, Davis Heart and Lung Research Institute, The Ohio State University Medical Center, Columbus, OH 43210, USA
    Mol Ther 13:211-20. 2006
    ..Taken together, this work presents the first in vivo evidence indicating that strategies to influence the redox environment of the wound site may have a bearing on healing outcomes...
  32. ncbi request reprint MicroRNA in cutaneous wound healing: a new paradigm
    Shani Shilo
    Laboratory of Molecular Medicine, Department of Surgery, Davis Heart and Lung Research Institute, The Ohio State University Medical Center, Columbus, Ohio, USA
    DNA Cell Biol 26:227-37. 2007
    ..If tested positive, this hypothesis is likely to lead to completely novel diagnostic and therapeutic strategies for the treatment of problem wounds...
  33. ncbi request reprint Algorithms for mapping of mRNA targets for microRNA
    Ilya Ioshikhes
    Department of Biomedical Informatics, Davis Heart and Lung Research Institute, The Ohio State University Medical Center, Columbus, Ohio 43210, USA
    DNA Cell Biol 26:265-72. 2007
    ..Strategies for improvement of the current bioinformatics tools and effective approaches for biological validation are discussed...
  34. pmc Differentiation of bone marrow mesenchymal stem cells into the smooth muscle lineage by blocking ERK/MAPK signaling pathway
    Kenichi Tamama
    Department of Pathology, Ohio State University Medical Center, Columbus, Ohio 43210, USA
    Stem Cells Dev 17:897-908. 2008
    ..This approach has obvious implications for cell therapeutics and tissue engineering of hollow visceral organs such as blood vessels...
  35. pmc Evidence-based recommendations for the use of topical oxygen therapy in the treatment of lower extremity wounds
    Gayle M Gordillo
    Division of Plastic Surgery, Department of Surgery, College of Medicine, The Ohio State University, Columbus, Ohio 43210, USA
    Int J Low Extrem Wounds 8:105-11. 2009
    ..Randomized controlled trials are not yet reported and clearly necessary. The current body of evidence suggests that topical oxygen therapy may be considered as a second line of therapy for refractory wounds...
  36. pmc MicroRNA expression in response to murine myocardial infarction: miR-21 regulates fibroblast metalloprotease-2 via phosphatase and tensin homologue
    Sashwati Roy
    Department of Surgery, Davis Heart and Lung Research Institute, The Ohio State University Medical Center, 473 West 12th Avenue, Columbus, OH 43210, USA
    Cardiovasc Res 82:21-9. 2009
    ..For the first time, we sought to test how myocardial ischaemia-reperfusion (IR) changes miR expression...
  37. pmc P21waf1/cip1/sdi1 as a central regulator of inducible smooth muscle actin expression and differentiation of cardiac fibroblasts to myofibroblasts
    Sashwati Roy
    Laboratory of Molecular Medicine, Department of Surgery, Davis Heart and Lung Research Institute, The Ohio State University Medical Center, Columbus, OH 43210, USA
    Mol Biol Cell 18:4837-46. 2007
    ..This observation establishes p21 as a central regulator of reperfusion-induced phenotypic switch of CFs to myofibroblasts...
  38. pmc Assessment of wound-site redox environment and the significance of Rac2 in cutaneous healing
    Navdeep Ojha
    Department of Surgery, Ohio State University Medical Center, Columbus, OH 43210, USA
    Free Radic Biol Med 44:682-91. 2008
    ..Taken together, the findings of this study support that the wound site is rich in oxidants. Rac2 significantly contributes to oxidant production at the wound site and supports the healing process...
  39. doi request reprint Redox regulation of the VEGF signaling path and tissue vascularization: Hydrogen peroxide, the common link between physical exercise and cutaneous wound healing
    Sashwati Roy
    Department of Surgery, Davis Heart and Lung Research Institute, The Ohio State University Medical Center, Columbus, OH 43210, USA
    Free Radic Biol Med 44:180-92. 2008
    ..Numerous antioxidants exhibit antiangiogenic properties. Current evidence lends firm credence to the hypothesis that low-level endogenous H(2)O(2) supports vascular growth...
  40. pmc Oral administration of blueberry inhibits angiogenic tumor growth and enhances survival of mice with endothelial cell neoplasm
    Gayle Gordillo
    Division of Plastic Surgery, Department of Surgery, Davis Heart Lung Research Institute, The Ohio State University, Columbus, Ohio 43210, USA
    Antioxid Redox Signal 11:47-58. 2009
    ..Oral administration of BBE represents a potential therapeutic antiangiogenic strategy for treating endothelial cell neoplasms in children...
  41. doi request reprint Characterization of the structural and functional changes in the myocardium following focal ischemia-reperfusion injury
    Navdeep Ojha
    Department of Surgery, Davis Heart and Lung Research Institute, The Ohio State University Medical Center, Columbus, OH, USA
    Am J Physiol Heart Circ Physiol 294:H2435-43. 2008
    ..Myocardial remodeling following I/R includes secondary myocyte death followed by the loss of cardiac function over time...
  42. pmc Topical oxygen therapy induces vascular endothelial growth factor expression and improves closure of clinically presented chronic wounds
    Gayle M Gordillo
    The Comprehensive Wound Center, The Ohio State University Medical Center, Columbus, Ohio 43210, USA
    Clin Exp Pharmacol Physiol 35:957-64. 2008
    ..Treatment with TO is associated with an induction of VEGF expression in wound edge tissue and an improvement in wound size...
  43. pmc Translational informatics: enabling high-throughput research paradigms
    Philip R O Payne
    Department of Biomedical Informatics, The Ohio State University, Columbus, Ohio 43210, USA
    Physiol Genomics 39:131-40. 2009
    ..The objective of presenting such findings and constructs is to provide the clinical and translational research community with a common frame of reference for discussing and expanding upon such models and methodologies...
  44. pmc Hypoxia inducible microRNA 210 attenuates keratinocyte proliferation and impairs closure in a murine model of ischemic wounds
    Sabyasachi Biswas
    Department of Surgery, Ohio State University Medical Center, Columbus, OH 43210, USA
    Proc Natl Acad Sci U S A 107:6976-81. 2010
    ....
  45. ncbi request reprint Mitochondrial nitric oxide synthase
    Pedram Ghafourifar
    Department of Surgery and Davis Heart and Lung Research Institute, The Ohio State University, Columbus, Ohio 43210, USA
    Front Biosci 12:1072-8. 2007
    ..The present article reviews the current understanding of the interactions between mitochondria, and NO and peroxynitrite...
  46. ncbi request reprint Oxygen, oxidants, and antioxidants in wound healing: an emerging paradigm
    Chandan K Sen
    Laboratory of Molecular Medicine, Dorothy M Davis Heart and Lung Research Institute, Department of Surgery CMIS, The Ohio State University Medical Center, Columbus, Ohio 43210, USA
    Ann N Y Acad Sci 957:239-49. 2002
    ..Strategies to manipulate the redox environment in the wound are likely to be of outstanding significance in wound healing...
  47. ncbi request reprint Dermal excisional wound healing in pigs following treatment with topically applied pure oxygen
    Richard B Fries
    Laboratory of Molecular Medicine, Dorothy M Davis Heart and Lung Research Institute and Comprehensive Wound Center, Department of Surgery, The Ohio State University Medical Center, Columbus, OH 43210, USA
    Mutat Res 579:172-81. 2005
    ..Topically applied pure oxygen has the potential of benefiting some wound types. Further studies testing the potential of topical oxygen in pre-clinical and clinical settings are warranted...
  48. ncbi request reprint Characterization of perceived hyperoxia in isolated primary cardiac fibroblasts and in the reoxygenated heart
    Sashwati Roy
    Laboratory of Molecular Medicine, Department of Surgery, Davis Heart and Lung Research Institute, The Ohio State University Medical Center, 473 West 12th Avenue, Columbus, OH 43210, USA
    J Biol Chem 278:47129-35. 2003
    ..Furthermore, the first evidence demonstrating activation of perceived hyperoxia sensitive genes in the cardiac I-R tissue is presented...
  49. ncbi request reprint Body weight and abdominal fat gene expression profile in response to a novel hydroxycitric acid-based dietary supplement
    Sashwati Roy
    Laboratory of Molecular Medicine, Department of Surgery, The Ohio State University Medical Center, Columbus, OH 43210, USA
    Gene Expr 11:251-62. 2004
    ..Functional characterization of HCA-SX-sensitive genes revealed that upregulation of genes encoding serotonin receptors represent a distinct effect of dietary HCA-SX supplementation...
  50. doi request reprint HSP27 regulates p53 transcriptional activity in doxorubicin-treated fibroblasts and cardiac H9c2 cells: p21 upregulation and G2/M phase cell cycle arrest
    C D Venkatakrishnan
    The Ohio State University, Columbus, OH 43210, USA
    Am J Physiol Heart Circ Physiol 294:H1736-44. 2008
    ..Overall, HSP27 binding to p53 attenuated the cellular toxicity by upregulating p21 and prevented cell death...
  51. ncbi request reprint Anti-angiogenic property of edible berry in a model of hemangioma
    Mustafa Atalay
    Laboratory of Molecular Medicine, Department of Surgery, 512 Dorothy M Davis Heart and Lung Research Institute, The Ohio State University Medical Center, 473 W 12th Avenue, Columbus 43210, USA
    FEBS Lett 544:252-7. 2003
    ..The current results provide the first in vivo evidence substantiating the anti-angiogenic property of edible berries...
  52. ncbi request reprint Laser microdissection and pressure-catapulting technique to study gene expression in the reoxygenated myocardium
    Donald E Kuhn
    Laboratory of Molecular Medicine, Department of Surgery, Davis Heart and Lung Research Institute, Ohio State University Medical Center, 473 W 12th Avenue, Columbus, OH 43210, USA
    Am J Physiol Heart Circ Physiol 290:H2625-32. 2006
    ..This work reports a sophisticated yet rapid approach to measurement of relative gene expressions from tissue elements captured from spatially resolved microscopic regions in the heart with micrometer-level precision...
  53. pmc Characterization of the acute temporal changes in excisional murine cutaneous wound inflammation by screening of the wound-edge transcriptome
    Sashwati Roy
    Comprehensive Wound Center, Department of Surgery, Davis Heart and Lung Research Institute, The Ohio State University Medical Center, Columbus, Ohio 43210, USA
    Physiol Genomics 34:162-84. 2008
    ..This study provides a digested database that may serve as a valuable reference tool to develop novel hypotheses aiming to elucidate the biology of cutaneous wound healing comprehensively...
  54. doi request reprint Redox-active antioxidant modulation of lipid signaling in vascular endothelial cells: vitamin C induces activation of phospholipase D through phospholipase A2, lipoxygenase, and cyclooxygenase
    Emily Steinhour
    Lipid Signaling and Lipidomics Laboratory, Division of Pulmonary, Allergy, Critical Care, and Sleep Medicine, Department of Medicine, College of Medicine, The Ohio State University, Columbus, OH, USA
    Mol Cell Biochem 315:97-112. 2008
    ....
  55. ncbi request reprint Hyperbaric oxygen therapy ameliorates stress-impaired dermal wound healing
    Praveen K Gajendrareddy
    Department of Oral Biology, College of Dentistry, The Ohio State University, Columbus, OH 43210, USA
    Brain Behav Immun 19:217-22. 2005
    ..Our current findings represent the first experimental evidence, demonstrating that HBO corrects stress-impaired dermal wound healing...
  56. ncbi request reprint Human genome screen to identify the genetic basis of the anti-inflammatory effects of Boswellia in microvascular endothelial cells
    Sashwati Roy
    Laboratory of Molecular Medicine, Department of Surgery, The Ohio State University Medical Center, Columbus, Ohio 43210, USA
    DNA Cell Biol 24:244-55. 2005
    ..These findings warrant further research aimed at identifying the signaling mechanisms by which BE exerts its anti-inflammatory effects...
  57. ncbi request reprint The general case for redox control of wound repair
    Chandan K Sen
    Dorothy M Davis Heart and Lung Research Institute, Department of Surgery, The Ohio State University Medical Center, Columbus, Ohio 43210, USA
    Wound Repair Regen 11:431-8. 2003
    ..While a window of therapeutic opportunity seems to exist under conditions of low concentrations of reactive oxygen species, high levels may complicate regeneration and remodeling of nascent tissue...
  58. ncbi request reprint Perceived hyperoxia: oxygen-regulated signal transduction pathways in the heart
    Sashwati Roy
    Laboratory of Molecular Medicine, Department of Surgery, Davis Heart and Lung Research Institute, The Ohio State University Medical Center, Columbus, Ohio 43210, USA
    Methods Enzymol 381:133-9. 2004
  59. pmc Wound angiogenesis as a function of tissue oxygen tension: a mathematical model
    Richard C Schugart
    Mathematical Bioscience Institute, Ohio State University, Columbus, OH 43210, USA
    Proc Natl Acad Sci U S A 105:2628-33. 2008
    ..The simulated results agree with the reported literature on the biology of wound healing. The proposed model represents a useful tool to analyze strategies for improved healing and generate a hypothesis for experimental testing...
  60. pmc Oxygen-sensitive outcomes and gene expression in acute ischemic stroke
    Cameron Rink
    Department of Surgery, The Ohio State University Medical Center, 473 W 12th Avenue, Columbus, OH 43210, USA
    J Cereb Blood Flow Metab 30:1275-87. 2010
    ..The findings provide key information relevant to understanding oxygen-dependent molecular mechanisms in the AIS-affected brain...
  61. pmc Characterization of the potent neuroprotective properties of the natural vitamin E alpha-tocotrienol
    Savita Khanna
    Laboratory of Molecular Medicine, Department of Surgery, Davis Heart and Lung Research Institute, The Ohio State University Medical Center, Colombus, Ohio 43210, USA
    J Neurochem 98:1474-86. 2006
    ..Oral supplementation of alpha-tocotrienol to humans results in a peak plasma concentration of 3 microm. Thus, oral alpha-tocotrienol may be neuroprotective by antioxidant-independent as well as antioxidant-dependent mechanisms...
  62. pmc The role of the NADPH oxidase complex, p38 MAPK, and Akt in regulating human monocyte/macrophage survival
    Yijie Wang
    Dorothy M Davis Heart and Lung Research Institute, Department of Internal Medicine, Ohio State University Medical Center, Columbus, OH 43210, USA
    Am J Respir Cell Mol Biol 36:68-77. 2007
    ..These findings demonstrate that ROS generated from the NADPH oxidase complex contribute to monocyte/macrophage survival induced by M-CSF via regulation of Akt and p38 MAPK...
  63. ncbi request reprint A key angiogenic role of monocyte chemoattractant protein-1 in hemangioendothelioma proliferation
    Gayle M Gordillo
    Division of Plastic Surgery, The Ohio State University Medical Center, 410 W 10th Ave, Columbus, OH 43210, USA
    Am J Physiol Cell Physiol 287:C866-73. 2004
    ..This study has produced the first in vivo evidence of a complete response for any neoplasm, specifically a vascular proliferative lesion, to anti-MCP-1 therapy in animals with intact immune systems...
  64. ncbi request reprint Protocols for topical and systemic oxygen treatments in wound healing
    Gayle M Gordillo
    Laboratory of Molecular Medicine, Department of Surgery, The Ohio State University Medical Center, Columbus, Ohio 43210, USA
    Methods Enzymol 381:575-85. 2004
  65. ncbi request reprint Reactive oxygen species and EGR-1 gene expression in surgical postoperative peritoneal adhesions
    Sashwati Roy
    Department of Surgery, Center for Minimally Invasive Surgery, Laboratory of Molecular Medicine, Davis Heart and Lung Research Institute, The Ohio State University, 473 W 12th Avenue, Columbus, OH 73210, USA
    World J Surg 28:316-20. 2004
    ..The newly developed rodent model of adhesion may present a useful approach to reproducibly and objectively study molecular mechanisms underlying the dynamic process of de novo adhesion tissue formation...
  66. pmc Tocotrienols: the emerging face of natural vitamin E
    Chandan K Sen
    Laboratory of Molecular Medicine, Department of Surgery, Davis Heart and Lung Research Institute, The Ohio State University Medical Center, Columbus, Ohio 43210, USA
    Vitam Horm 76:203-61. 2007
    ..The current state of knowledge warrants strategic investment into the lesser known forms of vitamin E. This will enable prudent selection of the appropriate vitamin E molecule for studies addressing a specific health need...
  67. ncbi request reprint Natural vitamin E alpha-tocotrienol: retention in vital organs in response to long-term oral supplementation and withdrawal
    Viren Patel
    Laboratory of Molecular Medicine, Department of Surgery, Dorothy M Davis Heart and Lung Research Institute, The Ohio State University Medical Center, Columbus, OH 43210, USA
    Free Radic Res 40:763-71. 2006
    ....
  68. pmc Natural vitamin E α-tocotrienol protects against ischemic stroke by induction of multidrug resistance-associated protein 1
    Han A Park
    Department of Surgery, Davis Heart and Lung Research Institute, Ohio State University Medical Center, Columbus, Ohio, USA
    Stroke 42:2308-14. 2011
    ..Multidrug resistance-associated protein 1 (MRP1), a key mediator of intracellular oxidized glutathione efflux from neural cells, may therefore possess neuroprotective functions...
  69. ncbi request reprint Heat shock protein 60 response to exercise in diabetes: effects of alpha-lipoic acid supplementation
    Niku K J Oksala
    Department of Physiology, University of Kuopio, Finland
    J Diabetes Complications 20:257-61. 2006
    ..Acute exercise increased liver 4-HNE, which was offset by LA. In conclusion, diabetes induced oxidative stress and impaired myocardial HSP60 expression, while LA partially offsets these alterations in a tissue-specific manner...
  70. ncbi request reprint Significance of oxygen therapeutics
    Gayle M Gordillo
    Wound Repair Regen 11:393; author reply 393. 2003
  71. ncbi request reprint Oxygen: at the foundation of wound healing--introduction
    Thomas K Hunt
    World J Surg 28:291-3. 2004
    ..A historical and evolutionary perspective on the role of oxygen in wound healing--from the classical physiology of oxygen in the wound to the refined concept of redox signaling--is presented...
  72. ncbi request reprint Redox regulation of mitochondrial permeability transition: effects of uncoupler, lipoic acid and its positively charged analog LA-plus and selenium
    Oren Tirosh
    Institute of Biochemistry, Food Science and Nutrition, The Hebrew University of Jerusalem, Rehovot 76100, Israel
    Biofactors 17:297-306. 2003
  73. ncbi request reprint Restraint stress alters lung gene expression in an experimental influenza A viral infection
    Andrea Engler
    Laboratory of Neuroendocrine Immunology, Section of Oral Biology, College of Dentistry, The Ohio State University Health Sciences Center, Columbus, OH 43210, USA
    J Neuroimmunol 162:103-11. 2005
    ....
  74. pmc Aerobically derived lactate stimulates revascularization and tissue repair via redox mechanisms
    Thomas K Hunt
    Wound Healing Laboratory, University of California San Francisco, San Francisco, California 94143 0522, USA
    Antioxid Redox Signal 9:1115-24. 2007
    ..Accumulated lactate, therefore, appears to convey the impression of "metabolic need" for vascularization, even in well-oxygenated and pH-neutral conditions. Lactate and oxygen together stimulate angiogenesis and matrix deposition...
  75. pmc 12(S)-hydroperoxyeicosatetraenoic acid (12-HETE) increases mitochondrial nitric oxide by increasing intramitochondrial calcium
    Rafal R Nazarewicz
    Department of Surgery, Davis Heart and Lung Research Institute, Institute of Mitochondrial Biology, The Ohio State University, 460 West 12th Avenue, Columbus, OH 43210, USA
    Arch Biochem Biophys 468:114-20. 2007
    ..Similarly, in HL-1 cardiac myocytes, 12-HETE increases intramitochondrial calcium and mitochondrial NO, and induces apoptosis. The present study suggests a novel mechanism for 12-HETE toxicity...
  76. ncbi request reprint Simultaneous detection of tocopherols and tocotrienols in biological samples using HPLC-coulometric electrode array
    Sashwati Roy
    Departments of Surgery and Molecular and Cellular Biochemistry, Laboratory of Molecular Medicine, Davis Heart and Lung Research Institute, Ohio State University, Columbus, Ohio 43210, USA
    Methods Enzymol 352:326-32. 2002
  77. ncbi request reprint Hemangioma model for in vivo angiogenesis: inducible oxidative stress and MCP-1 expression in EOMA cells
    Gayle M Gordillo
    Department of Surgery, Laboratory of Molecular Medicine, Davis Heart and Lung Research Institute, Ohio State University, Columbus, Ohio 43210, USA
    Methods Enzymol 352:422-32. 2002
  78. pmc Vitamin E sensitive genes in the developing rat fetal brain: a high-density oligonucleotide microarray analysis
    Sashwati Roy
    Laboratory of Molecular Medicine, Department of Surgery and Molecular and Cellular Biochemistry, Davis Heart and Lung Research Institute, The Ohio State University Medical Center, 473 W 12th Avenue, Columbus 43210, USA
    FEBS Lett 530:17-23. 2002
    ..The enrichment is more in fetal brain tissue. Using a GeneChip microarray expression profiling approach we have identified a specific set of vitamin E sensitive genes in the developing rat fetal brain...
  79. ncbi request reprint Transcriptome of primary adipocytes from obese women in response to a novel hydroxycitric acid-based dietary supplement
    Sashwati Roy
    Laboratory of Molecular Medicine and the Microarray Core Facility, Department of Surgery, Davis Heart and Lung Research Institute, The Ohio State University Medical Center, Columbus, Ohio 43210, USA
    DNA Cell Biol 26:627-39. 2007
    ..Although HCA-SX seems to be conditionally effective in weight management in experimental animals and in humans, its mechanism of action remains unclear...
  80. pmc Delivery of orally supplemented alpha-tocotrienol to vital organs of rats and tocopherol-transport protein deficient mice
    Savita Khanna
    Laboratory of Molecular Medicine, Department of Surgery, Davis Heart and Lung Research Institute, The Ohio State University Medical Center, Columbus, OH 43210, USA
    Free Radic Biol Med 39:1310-9. 2005
    ..Examination of whether alpha-TCT may benefit humans suffering from neurological disorders because of congenital TTP deficiency is warranted...
  81. ncbi request reprint Wound site neutrophil transcriptome in response to psychological stress in young men
    Sashwati Roy
    Laboratory of Molecular Medicine, Department of Surgery, Davis Heart and Lung Research Institute, The Ohio State University Medical Center, Columbus, OH 43210, USA
    Gene Expr 12:273-87. 2005
    ..Further effort to gain a more comprehensive understanding of the functional significance of such behavior-genome interaction is warranted...
  82. ncbi request reprint DNA microarray technology in nutraceutical and food safety
    Yiwen Liu-Stratton
    Laboratory of Molecular Medicine and DNA Microarray and Genetics Facility, Department of Surgery, Dorothy M Davis Heart and Lung Research Institute, The Ohio State University Medical Center, 473 W 12th Avenue, Columbus, OH 43210, USA
    Toxicol Lett 150:29-42. 2004
    ..Optimization of this technology to specifically address food safety is a vast resource that remains to be mined. Efforts to develop diagnostic custom arrays and simplified bioinformatics tools for field use are warranted...
  83. pmc Neuroprotective properties of the natural vitamin E alpha-tocotrienol
    Savita Khanna
    Department of Surgery, The Ohio State University Medical Center, Columbus, Ohio, USA
    Stroke 36:2258-64. 2005
    ....
  84. ncbi request reprint Microarray analysis of gene expression: considerations in data mining and statistical treatment
    Joseph S Verducci
    Davis Heart and Lung Research Institute, Department of Surgery, The Ohio State University, Columbus, Ohio, USA
    Physiol Genomics 25:355-63. 2006
    ....
  85. ncbi request reprint Regulation of vascular responses to inflammation: inducible matrix metalloproteinase-3 expression in human microvascular endothelial cells is sensitive to antiinflammatory Boswellia
    Sashwati Roy
    Laboratory of Molecular Medicine, Department of Surgery, The Ohio State University Medical Center, Columbus, OH 43210, USA
    Antioxid Redox Signal 8:653-60. 2006
    ..In all experiments, both in vitro and in vivo, BE30% was more effective than BE3%. In sum, this work lends support to our previous report that BE has potent antiinflammatory properties both in vitro as well as in vivo...
  86. ncbi request reprint Dietary antioxidants for the athlete
    Mustafa Atalay
    512 Davis Heart and Lung Research Institute, 473 West 12th Avenue, The Ohio State University Medical Center, Columbus, OH 43210, USA
    Curr Sports Med Rep 5:182-6. 2006
    ..Overall well being of the athlete, faster recovery, and minimization of injury time could all be affected by antioxidant therapy...
  87. ncbi request reprint Relief from a heavy heart: redox-sensitive NF-kappaB as a therapeutic target in managing cardiac hypertrophy
    Chandan K Sen
    Am J Physiol Heart Circ Physiol 289:H17-9. 2005
  88. ncbi request reprint miRNA: licensed to kill the messenger
    Chandan K Sen
    DNA Cell Biol 26:193-4. 2007
    ..Having acknowledged the potential risk, we have to recognize that new knowledge about the functional roles of miRNA is revolutionizing cell biology and will have a major impact on biomedical research imminently...

Research Grants21

  1. microRNA Control of Wound Healing
    Chandan K Sen; Fiscal Year: 2010
    ..This light originates from recent breakthrough discoveries recognizing a novel class of genes - previously thought to be junk - called microRNAs as being of critical significance in health and disease. ..
  2. Vitamin E Neuroprotection: Novel Molecular Mechanisms
    Chandan Sen; Fiscal Year: 2002
    ..This study will lay the foundation for a safe and efficient approach to prevent death and secure normal functioning of neurons under challenging conditions. ..
  3. Tissue oxygenation and wound angiogenesis
    Chandan Sen; Fiscal Year: 2007
    ..Determine whether oxygenation accelerates wound closure; iii. Determine if correction of wound hypoxia facilitates angiogenesis and blood flow. ..
  4. Oxygen Sensitive Signaling in Primary Cardiac Fibroblast
    Chandan Sen; Fiscal Year: 2006
    ..This raises a significant broad-based issue of controlling ambient O2 during cell culture. Finally, an isolated cell culture model to study chronic moderate hypoxia followed by reoxygenation is offered. ..
  5. Vitamin E Neuroprotection: Novel Molecular Mechanisms
    Chandan Sen; Fiscal Year: 2009
    ..NARRATIVE The project seeks to establish 1-tocotrienol, a natural vitamin E poorly present in American diet, as a dietary ingredient effective against stroke-related damage to the neural tissue. ..
  6. Oxygen Sensitive Signaling in Primary Cardiac Fibroblast
    Chandan Sen; Fiscal Year: 2007
    ..This raises a significant broad-based issue of controlling ambient O2 during cell culture. Finally, an isolated cell culture model to study chronic moderate hypoxia followed by reoxygenation is offered. ..
  7. Redox Control of Wound Healing
    Chandan Sen; Fiscal Year: 2007
    ..Determine the significance of NADPH oxidases at the wound site; and Aim 3. Characterize the redox-sensitive mechanisms that regulate wound angiogenesis. ..
  8. Tissue oxygenation and wound angiogenesis
    Chandan K Sen; Fiscal Year: 2010
    ..Determine whether oxygenation accelerates wound closure;iii. Determine if correction of wound hypoxia facilitates angiogenesis and blood flow. ..
  9. Redox Control of Wound Healing
    Chandan Sen; Fiscal Year: 2005
    ..Determine the significance of NADPH oxidases at the wound site; and Aim 3. Characterize the redox-sensitive mechanisms that regulate wound angiogenesis. ..
  10. Conference--Wound Healing : O2 and Emerging Therapeutics
    Chandan Sen; Fiscal Year: 2002
    ..Oxygen Sensing Oxidant Signaling & Redox Regulated Gene Expression Oxygen Therapy of Wounds Potential and Limitations of Clinical Gene Therapy for Wound Care Wound Angiogenesis Inflammation and Bacterial Control Clinical Care ..
  11. Vitamin E Neuroprotection: Novel Molecular Mechanisms
    Chandan Sen; Fiscal Year: 2003
    ..This study will lay the foundation for a safe and efficient approach to prevent death and secure normal functioning of neurons under challenging conditions. ..
  12. Vitamin E Neuroprotection: Novel Molecular Mechanisms
    Chandan Sen; Fiscal Year: 2004
    ..This study will lay the foundation for a safe and efficient approach to prevent death and secure normal functioning of neurons under challenging conditions. ..
  13. Redox Control of Wound Healing
    Chandan Sen; Fiscal Year: 2004
    ..Determine the significance of NADPH oxidases at the wound site; and Aim 3. Characterize the redox-sensitive mechanisms that regulate wound angiogenesis. ..
  14. Oxygen Sensitive Signaling in Primary Cardiac Fibroblast
    Chandan Sen; Fiscal Year: 2004
    ..This raises a significant broad-based issue of controlling ambient O2 during cell culture. Finally, an isolated cell culture model to study chronic moderate hypoxia followed by reoxygenation is offered. ..
  15. Vitamin E Neuroprotection: Novel Molecular Mechanisms
    Chandan Sen; Fiscal Year: 2005
    ..This study will lay the foundation for a safe and efficient approach to prevent death and secure normal functioning of neurons under challenging conditions. ..
  16. Oxygen Sensitive Signaling in Primary Cardiac Fibroblast
    Chandan Sen; Fiscal Year: 2005
    ..This raises a significant broad-based issue of controlling ambient O2 during cell culture. Finally, an isolated cell culture model to study chronic moderate hypoxia followed by reoxygenation is offered. ..
  17. Tissue oxygenation and wound angiogenesis
    Chandan Sen; Fiscal Year: 2009
    ..Determine whether oxygenation accelerates wound closure; iii. Determine if correction of wound hypoxia facilitates angiogenesis and blood flow. ..
  18. Vitamin E Neuroprotection: Novel Molecular Mechanisms
    Chandan K Sen; Fiscal Year: 2010
    ..NARRATIVE The project seeks to establish 1-tocotrienol, a natural vitamin E poorly present in American diet, as a dietary ingredient effective against stroke-related damage to the neural tissue. ..
  19. Redox Control of Wound Healing
    Chandan Sen; Fiscal Year: 2006
    ..Determine the significance of NADPH oxidases at the wound site; and Aim 3. Characterize the redox-sensitive mechanisms that regulate wound angiogenesis. ..