C K Sen

Summary

Affiliation: The Ohio State University
Country: USA

Publications

  1. ncbi request reprint Oxygen: from the benefits of inducing VEGF expression to managing the risk of hyperbaric stress
    Viren Patel
    Laboratory of Molecular Medicine, Department of Surgery, The Ohio State University Medical Center, Columbus, OH 43210, USA
    Antioxid Redox Signal 7:1377-87. 2005
  2. ncbi request reprint Perceived hyperoxia: oxygen-induced remodeling of the reoxygenated heart
    Chandan K Sen
    Laboratory of Molecular Medicine, 512 Davis Heart and Lung Research Institute, Department of Surgery, The Ohio State University Medical Center, 473 W 12th Avenue, Columbus, 43210, USA
    Cardiovasc Res 71:280-8. 2006
  3. doi request reprint Evidence for the involvement of miRNA in redox regulated angiogenic response of human microvascular endothelial cells
    Shani Shilo
    Comprehensive Wound Center, Department of Surgery, The Ohio State University Medical Center, Columbus, Ohio 43210, USA
    Arterioscler Thromb Vasc Biol 28:471-7. 2008
  4. pmc Characterization of the acute temporal changes in excisional murine cutaneous wound inflammation by screening of the wound-edge transcriptome
    Sashwati Roy
    Comprehensive Wound Center, Department of Surgery, Davis Heart and Lung Research Institute, The Ohio State University Medical Center, Columbus, Ohio 43210, USA
    Physiol Genomics 34:162-84. 2008
  5. ncbi request reprint Thiol homeostasis and supplements in physical exercise
    C K Sen
    Departments of Surgery and Molecular and Cellular Biochemistry, The Ohio State University Medical Center, Columbus, OH 43210 1252, USA
    Am J Clin Nutr 72:653S-69S. 2000
  6. ncbi request reprint Oxidant-induced vascular endothelial growth factor expression in human keratinocytes and cutaneous wound healing
    Chandan K Sen
    Laboratory of Molecular Medicine, Dorothy M Davis Heart and Lung Research Institute, Department of Surgery Center for Minimally Invasive Surgery, The Ohio State University Medical Center, Columbus, Ohio 43210, USA
    J Biol Chem 277:33284-90. 2002
  7. ncbi request reprint Copper-induced vascular endothelial growth factor expression and wound healing
    Chandan K Sen
    Laboratory of Molecular Medicine, Department of Surgery, 512 Davis Heart and Lung Research Institute, The Ohio State University Medical Center, Columbus, Ohio 43210, USA
    Am J Physiol Heart Circ Physiol 282:H1821-7. 2002
  8. ncbi request reprint Tocotrienol: the natural vitamin E to defend the nervous system?
    Chandan K Sen
    Davis Heart and Lung Research Institute, 473 West 12th Avenue, The Ohio State University Medical Center, Columbus, Ohio 43210, USA
    Ann N Y Acad Sci 1031:127-42. 2004
  9. ncbi request reprint Antioxidants in exercise nutrition
    C K Sen
    Department of Surgery and Molecular and Cellular Biochemistry, Davis Heart and Lung Research Institute, The Ohio State University Medical Center, Columbus 43210, USA
    Sports Med 31:891-908. 2001
  10. ncbi request reprint The general case for redox control of wound repair
    Chandan K Sen
    Dorothy M Davis Heart and Lung Research Institute, Department of Surgery, The Ohio State University Medical Center, Columbus, Ohio 43210, USA
    Wound Repair Regen 11:431-8. 2003

Collaborators

Detail Information

Publications83

  1. ncbi request reprint Oxygen: from the benefits of inducing VEGF expression to managing the risk of hyperbaric stress
    Viren Patel
    Laboratory of Molecular Medicine, Department of Surgery, The Ohio State University Medical Center, Columbus, OH 43210, USA
    Antioxid Redox Signal 7:1377-87. 2005
    ..This is of special concern for people with inadequate intake of dietary antioxidants. Nutritional antioxidant supplementation may offset HBO-induced oxidative stress...
  2. ncbi request reprint Perceived hyperoxia: oxygen-induced remodeling of the reoxygenated heart
    Chandan K Sen
    Laboratory of Molecular Medicine, 512 Davis Heart and Lung Research Institute, Department of Surgery, The Ohio State University Medical Center, 473 W 12th Avenue, Columbus, 43210, USA
    Cardiovasc Res 71:280-8. 2006
    ..Understanding of the underlying mechanisms of this and other myocardial healing responses should prove to be instrumental in developing productive therapeutic approaches to mend the infarcted heart...
  3. doi request reprint Evidence for the involvement of miRNA in redox regulated angiogenic response of human microvascular endothelial cells
    Shani Shilo
    Comprehensive Wound Center, Department of Surgery, The Ohio State University Medical Center, Columbus, Ohio 43210, USA
    Arterioscler Thromb Vasc Biol 28:471-7. 2008
    ..A Dicer knockdown approach was used to test the significance of miRNA in regulating the redox state and angiogenic response of human microvascular endothelial cells (HMECs)...
  4. pmc Characterization of the acute temporal changes in excisional murine cutaneous wound inflammation by screening of the wound-edge transcriptome
    Sashwati Roy
    Comprehensive Wound Center, Department of Surgery, Davis Heart and Lung Research Institute, The Ohio State University Medical Center, Columbus, Ohio 43210, USA
    Physiol Genomics 34:162-84. 2008
    ..This study provides a digested database that may serve as a valuable reference tool to develop novel hypotheses aiming to elucidate the biology of cutaneous wound healing comprehensively...
  5. ncbi request reprint Thiol homeostasis and supplements in physical exercise
    C K Sen
    Departments of Surgery and Molecular and Cellular Biochemistry, The Ohio State University Medical Center, Columbus, OH 43210 1252, USA
    Am J Clin Nutr 72:653S-69S. 2000
    ..These agents may have antioxidant effects at the biochemical level but are also known to influence redox-sensitive cell signaling...
  6. ncbi request reprint Oxidant-induced vascular endothelial growth factor expression in human keratinocytes and cutaneous wound healing
    Chandan K Sen
    Laboratory of Molecular Medicine, Dorothy M Davis Heart and Lung Research Institute, Department of Surgery Center for Minimally Invasive Surgery, The Ohio State University Medical Center, Columbus, Ohio 43210, USA
    J Biol Chem 277:33284-90. 2002
    ..Taken together, the results of this study indicate that wound healing is subject to redox control...
  7. ncbi request reprint Copper-induced vascular endothelial growth factor expression and wound healing
    Chandan K Sen
    Laboratory of Molecular Medicine, Department of Surgery, 512 Davis Heart and Lung Research Institute, The Ohio State University Medical Center, Columbus, Ohio 43210, USA
    Am J Physiol Heart Circ Physiol 282:H1821-7. 2002
    ..Copper-sensitive pathways regulate key mediators of wound healing such as angiogenesis and extracellular matrix remodeling. Copper-based therapeutics represents a feasible approach to promote dermal wound healing...
  8. ncbi request reprint Tocotrienol: the natural vitamin E to defend the nervous system?
    Chandan K Sen
    Davis Heart and Lung Research Institute, 473 West 12th Avenue, The Ohio State University Medical Center, Columbus, Ohio 43210, USA
    Ann N Y Acad Sci 1031:127-42. 2004
    ..Dietary supplementation studies have established that tocotrienol, fed orally, does reach the brain. The current findings point towards tocotrienol as a potent neuroprotective form of natural vitamin E...
  9. ncbi request reprint Antioxidants in exercise nutrition
    C K Sen
    Department of Surgery and Molecular and Cellular Biochemistry, Davis Heart and Lung Research Institute, The Ohio State University Medical Center, Columbus 43210, USA
    Sports Med 31:891-908. 2001
    ..Efforts to determine individual needs of athletes and a balanced diet rich in antioxidant supplements are highly recommended...
  10. ncbi request reprint The general case for redox control of wound repair
    Chandan K Sen
    Dorothy M Davis Heart and Lung Research Institute, Department of Surgery, The Ohio State University Medical Center, Columbus, Ohio 43210, USA
    Wound Repair Regen 11:431-8. 2003
    ..While a window of therapeutic opportunity seems to exist under conditions of low concentrations of reactive oxygen species, high levels may complicate regeneration and remodeling of nascent tissue...
  11. ncbi request reprint Antioxidant regulation of cell adhesion
    C K Sen
    Departments of Surgery and Molecular and Cellular Biochemistry, Heart and Lung Research Institute, The Ohio State University Medical Center, Columbus, OH 43210, USA
    Med Sci Sports Exerc 33:377-81. 2001
    ..Whether such regulation has a redox component remains to be tested. Antioxidant supplementation studies testing the effect of exercise on cell adhesion should provide critical insight...
  12. ncbi request reprint Antioxidant and redox regulation of cellular signaling: introduction
    C K Sen
    Departments of Surgery and Molecular and Cellular Biochemistry, Heart and Lung Research Institute, The Ohio State University Medical Center, Columbus, OH 43210, USA
    Med Sci Sports Exerc 33:368-70. 2001
    ..The five component articles of this symposium discuss skeletal muscle contraction, cell adhesion, heat shock proteins, programmed cell death, and carbohydrate metabolism as they relate to physical exercise...
  13. ncbi request reprint Oxygen, oxidants, and antioxidants in wound healing: an emerging paradigm
    Chandan K Sen
    Laboratory of Molecular Medicine, Dorothy M Davis Heart and Lung Research Institute, Department of Surgery CMIS, The Ohio State University Medical Center, Columbus, Ohio 43210, USA
    Ann N Y Acad Sci 957:239-49. 2002
    ..Strategies to manipulate the redox environment in the wound are likely to be of outstanding significance in wound healing...
  14. ncbi request reprint Dermal wound healing properties of redox-active grape seed proanthocyanidins
    Savita Khanna
    Department of Surgery, Heart and Lung Research Institute, The Ohio State University Medical Center, Columbus, OH 43210, USA
    Free Radic Biol Med 33:1089-96. 2002
    ..In summary, our current study provides firm evidence to support that topical application of GSPE represents a feasible and productive approach to support dermal wound healing...
  15. ncbi request reprint Anti-angiogenic property of edible berries
    Sashwati Roy
    Laboratory of Molecular Medicine, Department of Surgery, 512 Heart and Lung Research Institute, Ohio State University Medical Center, 473 W 12th Avenue, Columbus, OH 43210, USA
    Free Radic Res 36:1023-31. 2002
    ..Matrigel assay using human dermal microvascular endothelial cells showed that edible berries impair angiogenesis...
  16. ncbi request reprint Upregulation of oxidant-induced VEGF expression in cultured keratinocytes by a grape seed proanthocyanidin extract
    S Khanna
    Laboratory of Molecular Medicine, Department of Surgery, The Ohio State University Medical Center, Columbus, OH, USA
    Free Radic Biol Med 31:38-42. 2001
    ..The current results suggest that GSPE may have beneficial therapeutic effects in promoting dermal wound healing and other related skin disorders...
  17. ncbi request reprint Update on thiol status and supplements in physical exercise
    C K Sen
    Laboratory of Molecular Medicine, Department of Surgery, 512 Heart and Lung Research Institute, The Ohio State University Medical Center, Columbus, OH 43210, USA
    Can J Appl Physiol 26:S4-12. 2001
    ..Under certain conditions oxidants may function as cellular messengers that regulate a multitude of signal transduction pathways. In light of this, the significance of oxidants in various aspects of biology needs to be revisited...
  18. doi request reprint Redox regulation of the VEGF signaling path and tissue vascularization: Hydrogen peroxide, the common link between physical exercise and cutaneous wound healing
    Sashwati Roy
    Department of Surgery, Davis Heart and Lung Research Institute, The Ohio State University Medical Center, Columbus, OH 43210, USA
    Free Radic Biol Med 44:180-92. 2008
    ..Numerous antioxidants exhibit antiangiogenic properties. Current evidence lends firm credence to the hypothesis that low-level endogenous H(2)O(2) supports vascular growth...
  19. pmc Neuroprotective properties of the natural vitamin E alpha-tocotrienol
    Savita Khanna
    Department of Surgery, The Ohio State University Medical Center, Columbus, Ohio, USA
    Stroke 36:2258-64. 2005
    ....
  20. pmc Assessment of wound-site redox environment and the significance of Rac2 in cutaneous healing
    Navdeep Ojha
    Department of Surgery, Ohio State University Medical Center, Columbus, OH 43210, USA
    Free Radic Biol Med 44:682-91. 2008
    ..Taken together, the findings of this study support that the wound site is rich in oxidants. Rac2 significantly contributes to oxidant production at the wound site and supports the healing process...
  21. pmc Molecular basis of vitamin E action: tocotrienol modulates 12-lipoxygenase, a key mediator of glutamate-induced neurodegeneration
    Savita Khanna
    Laboratory of Molecular Medicine, Department of Surgery, Dorothy M Davis Heart and Lung Research Institute, The Ohio State University Medical Center, Columbus, Ohio 43210, USA
    J Biol Chem 278:43508-15. 2003
    ..These findings lend further support to alpha-tocotrienol as a potent neuroprotective form of vitamin E...
  22. pmc Dermal wound healing is subject to redox control
    Sashwati Roy
    Laboratory of Molecular Medicine, Department of Surgery, Comprehensive Wound Center, Davis Heart and Lung Research Institute, The Ohio State University Medical Center, Columbus, OH 43210, USA
    Mol Ther 13:211-20. 2006
    ..Taken together, this work presents the first in vivo evidence indicating that strategies to influence the redox environment of the wound site may have a bearing on healing outcomes...
  23. pmc Nanomolar vitamin E alpha-tocotrienol inhibits glutamate-induced activation of phospholipase A2 and causes neuroprotection
    Savita Khanna
    Department of Surgery, Dorothy M Davis Heart and Lung Research Institute, The Ohio State University Medical Center, Columbus, OH 43210, USA
    J Neurochem 112:1249-60. 2010
    ..This work presents first evidence recognizing glutamate-induced changes in cPLA(2) as a novel mechanism responsible for neuroprotection observed in response to nanomolar concentrations of TCT...
  24. pmc Glutathione disulfide induces neural cell death via a 12-lipoxygenase pathway
    H A Park
    Department of Surgery, Davis Heart and Lung Research Institute, The Ohio State University Medical Center, Columbus, OH 43210, USA
    Cell Death Differ 16:1167-79. 2009
    ..Strategies directed at improving or arresting cellular GSSG clearance may be effective in minimizing oxidative stress-related tissue injury or potentiating the killing of tumor cells, respectively...
  25. pmc Wound healing essentials: let there be oxygen
    Chandan K Sen
    The Comprehensive Wound Center, Department of Surgery and Davis Heart and Lung Research Institute, The Ohio State University Medical Center, Columbus, Ohio, USA
    Wound Repair Regen 17:1-18. 2009
    ..Oxygen dosing based on the specific need of a wound therefore seems prudent. Therapeutic approaches targeting the oxygen sensing and redox signaling pathways are promising...
  26. ncbi request reprint Revisiting the essential role of oxygen in wound healing
    Gayle M Gordillo
    Department of Surgery, Laboratory of Molecular Medicine, 512 Davis Heart and Lung Research Institute, Ohio State University, 473 West 12th Ave, Columbus, OH 43210, USA
    Am J Surg 186:259-63. 2003
    ..Given that many growth factors require ROS for their function, it is reasonable to assume that approaches to correct wound pO(2) will serve as an effective adjunct in treating chronic wounds...
  27. pmc A mathematical model of ischemic cutaneous wounds
    Chuan Xue
    Mathematical Biosciences Institute and Department of Mathematics, Ohio State University, Columbus, OH 43210, USA
    Proc Natl Acad Sci U S A 106:16782-7. 2009
    ..Simulations of the model demonstrate how ischemic conditions may limit macrophage recruitment to the wound-site and impair wound closure. The results are in general agreement with experimental findings...
  28. ncbi request reprint A key angiogenic role of monocyte chemoattractant protein-1 in hemangioendothelioma proliferation
    Gayle M Gordillo
    Division of Plastic Surgery, The Ohio State University Medical Center, 410 W 10th Ave, Columbus, OH 43210, USA
    Am J Physiol Cell Physiol 287:C866-73. 2004
    ..This study has produced the first in vivo evidence of a complete response for any neoplasm, specifically a vascular proliferative lesion, to anti-MCP-1 therapy in animals with intact immune systems...
  29. pmc Topical oxygen therapy induces vascular endothelial growth factor expression and improves closure of clinically presented chronic wounds
    Gayle M Gordillo
    The Comprehensive Wound Center, The Ohio State University Medical Center, Columbus, Ohio 43210, USA
    Clin Exp Pharmacol Physiol 35:957-64. 2008
    ..Treatment with TO is associated with an induction of VEGF expression in wound edge tissue and an improvement in wound size...
  30. pmc Redox signals in wound healing
    Chandan K Sen
    Comprehensive Wound Center, Department of Surgery, Davis Heart and Lung Research Institute, The Ohio State University Medical Center, Columbus, Ohio 43210, USA
    Biochim Biophys Acta 1780:1348-61. 2008
    ..The objective of this review is to describe our current understanding of how redox-sensitive processes may drive dermal tissue repair...
  31. pmc Characterization of the potent neuroprotective properties of the natural vitamin E alpha-tocotrienol
    Savita Khanna
    Laboratory of Molecular Medicine, Department of Surgery, Davis Heart and Lung Research Institute, The Ohio State University Medical Center, Colombus, Ohio 43210, USA
    J Neurochem 98:1474-86. 2006
    ..Oral supplementation of alpha-tocotrienol to humans results in a peak plasma concentration of 3 microm. Thus, oral alpha-tocotrienol may be neuroprotective by antioxidant-independent as well as antioxidant-dependent mechanisms...
  32. pmc Characterization of a preclinical model of chronic ischemic wound
    Sashwati Roy
    Comprehensive Wound Center, Davis Heart and Lung Research Institute, Department of Surgery, The Ohio State University Medical Center, Columbus, Ohio 43210, USA
    Physiol Genomics 37:211-24. 2009
    ..This study provides a thorough database that may serve as a valuable reference tool to develop novel hypotheses aiming to elucidate the biology of ischemic chronic wounds in a preclinical setting...
  33. pmc Hypoxia inducible microRNA 210 attenuates keratinocyte proliferation and impairs closure in a murine model of ischemic wounds
    Sabyasachi Biswas
    Department of Surgery, Ohio State University Medical Center, Columbus, OH 43210, USA
    Proc Natl Acad Sci U S A 107:6976-81. 2010
    ....
  34. ncbi request reprint Dermal excisional wound healing in pigs following treatment with topically applied pure oxygen
    Richard B Fries
    Laboratory of Molecular Medicine, Dorothy M Davis Heart and Lung Research Institute and Comprehensive Wound Center, Department of Surgery, The Ohio State University Medical Center, Columbus, OH 43210, USA
    Mutat Res 579:172-81. 2005
    ..Topically applied pure oxygen has the potential of benefiting some wound types. Further studies testing the potential of topical oxygen in pre-clinical and clinical settings are warranted...
  35. ncbi request reprint Anti-angiogenic property of edible berry in a model of hemangioma
    Mustafa Atalay
    Laboratory of Molecular Medicine, Department of Surgery, 512 Dorothy M Davis Heart and Lung Research Institute, The Ohio State University Medical Center, 473 W 12th Avenue, Columbus 43210, USA
    FEBS Lett 544:252-7. 2003
    ..The current results provide the first in vivo evidence substantiating the anti-angiogenic property of edible berries...
  36. ncbi request reprint Hemangioma model for in vivo angiogenesis: inducible oxidative stress and MCP-1 expression in EOMA cells
    Gayle M Gordillo
    Department of Surgery, Laboratory of Molecular Medicine, Davis Heart and Lung Research Institute, Ohio State University, Columbus, Ohio 43210, USA
    Methods Enzymol 352:422-32. 2002
  37. ncbi request reprint Glutamate-induced c-Src activation in neuronal cells
    Savita Khanna
    Departments of Surgery and Molecular and Cellular Biochemistry, Laboratory of Molecular Medicine, Davis Heart and Lung Research Institute, Ohio State University, Columbus, Ohio 43210, USA
    Methods Enzymol 352:191-8. 2002
  38. ncbi request reprint Physical exercise induces activation of NF-kappaB in human peripheral blood lymphocytes
    J Vider
    Department of Surgery, Davis Heart and Lung Research Institute, The Ohio State University Medical Center, Columbus, USA
    Antioxid Redox Signal 3:1131-7. 2001
    ..Exercise-induced NF-kappaB activation in lymphocytes was associated with elevated levels of lipid peroxidation by-products in the plasma...
  39. ncbi request reprint Natural vitamin E alpha-tocotrienol: retention in vital organs in response to long-term oral supplementation and withdrawal
    Viren Patel
    Laboratory of Molecular Medicine, Department of Surgery, Dorothy M Davis Heart and Lung Research Institute, The Ohio State University Medical Center, Columbus, OH 43210, USA
    Free Radic Res 40:763-71. 2006
    ....
  40. ncbi request reprint MicroRNA in cutaneous wound healing: a new paradigm
    Shani Shilo
    Laboratory of Molecular Medicine, Department of Surgery, Davis Heart and Lung Research Institute, The Ohio State University Medical Center, Columbus, Ohio, USA
    DNA Cell Biol 26:227-37. 2007
    ..If tested positive, this hypothesis is likely to lead to completely novel diagnostic and therapeutic strategies for the treatment of problem wounds...
  41. pmc Tocotrienols: the emerging face of natural vitamin E
    Chandan K Sen
    Laboratory of Molecular Medicine, Department of Surgery, Davis Heart and Lung Research Institute, The Ohio State University Medical Center, Columbus, Ohio 43210, USA
    Vitam Horm 76:203-61. 2007
    ..The current state of knowledge warrants strategic investment into the lesser known forms of vitamin E. This will enable prudent selection of the appropriate vitamin E molecule for studies addressing a specific health need...
  42. ncbi request reprint Transcriptome of primary adipocytes from obese women in response to a novel hydroxycitric acid-based dietary supplement
    Sashwati Roy
    Laboratory of Molecular Medicine and the Microarray Core Facility, Department of Surgery, Davis Heart and Lung Research Institute, The Ohio State University Medical Center, Columbus, Ohio 43210, USA
    DNA Cell Biol 26:627-39. 2007
    ..Although HCA-SX seems to be conditionally effective in weight management in experimental animals and in humans, its mechanism of action remains unclear...
  43. pmc Wound angiogenesis as a function of tissue oxygen tension: a mathematical model
    Richard C Schugart
    Mathematical Bioscience Institute, Ohio State University, Columbus, OH 43210, USA
    Proc Natl Acad Sci U S A 105:2628-33. 2008
    ..The simulated results agree with the reported literature on the biology of wound healing. The proposed model represents a useful tool to analyze strategies for improved healing and generate a hypothesis for experimental testing...
  44. doi request reprint Oxygenation state as a driver of myofibroblast differentiation and wound contraction: hypoxia impairs wound closure
    Chandan K Sen
    Comprehensive Wound Center, Davis Heart and Lung Research Institute, Department of Surgery, The Ohio State University Medical Center, Columbus, Ohio 43210, USA
    J Invest Dermatol 130:2701-3. 2010
    ..They present compelling evidence indicating tissue hypoxia conflicts with wound closure. We are reminded that correcting wound tissue hypoxia is critical for the tissue's response to other therapeutic interventions...
  45. pmc Oral administration of blueberry inhibits angiogenic tumor growth and enhances survival of mice with endothelial cell neoplasm
    Gayle Gordillo
    Division of Plastic Surgery, Department of Surgery, Davis Heart Lung Research Institute, The Ohio State University, Columbus, Ohio 43210, USA
    Antioxid Redox Signal 11:47-58. 2009
    ..Oral administration of BBE represents a potential therapeutic antiangiogenic strategy for treating endothelial cell neoplasms in children...
  46. pmc Redox modification of ryanodine receptors contributes to sarcoplasmic reticulum Ca2+ leak in chronic heart failure
    Dmitry Terentyev
    Departments of Physiology and Cell Biology, College of Medicine, Ohio State University, Columbus, OH, USA
    Circ Res 103:1466-72. 2008
    ..These findings suggest that redox modification contributes to abnormal function of RyR2s in HF, presenting a potential therapeutic target for treating HF...
  47. ncbi request reprint Oxygen sensing by primary cardiac fibroblasts: a key role of p21(Waf1/Cip1/Sdi1)
    Sashwati Roy
    Laboratory of Molecular Medicine, Department of Surgery, Davis Heart and Lung Research Institute, The Ohio State University Medical Center, Columbus 43210, USA
    Circ Res 92:264-71. 2003
    ..CFs deficient in p21 were resistant to such O2 sensitivity. This study raises the vital broad-based issue of controlling ambient O2 during the culture of primary cells isolated from organs...
  48. pmc Fra-2 mediates oxygen-sensitive induction of transforming growth factor beta in cardiac fibroblasts
    Sashwati Roy
    Department of Surgery, The Ohio State University Medical Center, 513 Davis Heart and Lung Research Institute, 473 West 12th Avenue, Columbus, OH 43210, USA
    Cardiovasc Res 87:647-55. 2010
    ....
  49. pmc The role of the NADPH oxidase complex, p38 MAPK, and Akt in regulating human monocyte/macrophage survival
    Yijie Wang
    Dorothy M Davis Heart and Lung Research Institute, Department of Internal Medicine, Ohio State University Medical Center, Columbus, OH 43210, USA
    Am J Respir Cell Mol Biol 36:68-77. 2007
    ..These findings demonstrate that ROS generated from the NADPH oxidase complex contribute to monocyte/macrophage survival induced by M-CSF via regulation of Akt and p38 MAPK...
  50. ncbi request reprint Laser microdissection and pressure-catapulting technique to study gene expression in the reoxygenated myocardium
    Donald E Kuhn
    Laboratory of Molecular Medicine, Department of Surgery, Davis Heart and Lung Research Institute, Ohio State University Medical Center, 473 W 12th Avenue, Columbus, OH 43210, USA
    Am J Physiol Heart Circ Physiol 290:H2625-32. 2006
    ..This work reports a sophisticated yet rapid approach to measurement of relative gene expressions from tissue elements captured from spatially resolved microscopic regions in the heart with micrometer-level precision...
  51. ncbi request reprint Protocols for topical and systemic oxygen treatments in wound healing
    Gayle M Gordillo
    Laboratory of Molecular Medicine, Department of Surgery, The Ohio State University Medical Center, Columbus, Ohio 43210, USA
    Methods Enzymol 381:575-85. 2004
  52. pmc Micromanaging vascular biology: tiny microRNAs play big band
    Chandan K Sen
    Laboratory of Molecular Medicine, Department of Surgery, Davis Heart and Lung Research Institute, Ohio State University Medical Center, Columbus, Ohio 43210, USA
    J Vasc Res 46:527-40. 2009
    ..Prudent targeting of non-coding genes such as miRNAs, which in turn regulates large sets of coding genes, holds promise in gene therapy. Recent developments in miRNA biology offer lucrative opportunities to manage vascular health...
  53. pmc Tocotrienols: Vitamin E beyond tocopherols
    Chandan K Sen
    Department of Surgery, Davis Heart and Lung Research Institute, The Ohio State University Medical Center, Columbus, Ohio 43210, USA
    Life Sci 78:2088-98. 2006
    ..The current state of knowledge warrants strategic investment into the lesser known forms of vitamin E. This will enable prudent selection of the appropriate vitamin E molecule for studies addressing a specific need...
  54. ncbi request reprint Simultaneous detection of tocopherols and tocotrienols in biological samples using HPLC-coulometric electrode array
    Sashwati Roy
    Departments of Surgery and Molecular and Cellular Biochemistry, Laboratory of Molecular Medicine, Davis Heart and Lung Research Institute, Ohio State University, Columbus, Ohio 43210, USA
    Methods Enzymol 352:326-32. 2002
  55. doi request reprint Redox-active antioxidant modulation of lipid signaling in vascular endothelial cells: vitamin C induces activation of phospholipase D through phospholipase A2, lipoxygenase, and cyclooxygenase
    Emily Steinhour
    Lipid Signaling and Lipidomics Laboratory, Division of Pulmonary, Allergy, Critical Care, and Sleep Medicine, Department of Medicine, College of Medicine, The Ohio State University, Columbus, OH, USA
    Mol Cell Biochem 315:97-112. 2008
    ....
  56. ncbi request reprint Body weight and abdominal fat gene expression profile in response to a novel hydroxycitric acid-based dietary supplement
    Sashwati Roy
    Laboratory of Molecular Medicine, Department of Surgery, The Ohio State University Medical Center, Columbus, OH 43210, USA
    Gene Expr 11:251-62. 2004
    ..Functional characterization of HCA-SX-sensitive genes revealed that upregulation of genes encoding serotonin receptors represent a distinct effect of dietary HCA-SX supplementation...
  57. ncbi request reprint Wound site neutrophil transcriptome in response to psychological stress in young men
    Sashwati Roy
    Laboratory of Molecular Medicine, Department of Surgery, Davis Heart and Lung Research Institute, The Ohio State University Medical Center, Columbus, OH 43210, USA
    Gene Expr 12:273-87. 2005
    ..Further effort to gain a more comprehensive understanding of the functional significance of such behavior-genome interaction is warranted...
  58. pmc Gadolinium-containing phosphatidylserine liposomes for molecular imaging of atherosclerosis
    Andrei Maiseyeu
    Davis Heart and Lung Research Institute, Ohio State University, Columbus, OH, USA
    J Lipid Res 50:2157-63. 2009
    ..Gd-PS-enriched liposomes enhance atherosclerotic plaque and colocalize with macrophages in experimental atherosclerosis...
  59. ncbi request reprint Hyperbaric oxygen therapy ameliorates stress-impaired dermal wound healing
    Praveen K Gajendrareddy
    Department of Oral Biology, College of Dentistry, The Ohio State University, Columbus, OH 43210, USA
    Brain Behav Immun 19:217-22. 2005
    ..Our current findings represent the first experimental evidence, demonstrating that HBO corrects stress-impaired dermal wound healing...
  60. pmc Delivery of orally supplemented alpha-tocotrienol to vital organs of rats and tocopherol-transport protein deficient mice
    Savita Khanna
    Laboratory of Molecular Medicine, Department of Surgery, Davis Heart and Lung Research Institute, The Ohio State University Medical Center, Columbus, OH 43210, USA
    Free Radic Biol Med 39:1310-9. 2005
    ..Examination of whether alpha-TCT may benefit humans suffering from neurological disorders because of congenital TTP deficiency is warranted...
  61. pmc Oxygen-sensitive outcomes and gene expression in acute ischemic stroke
    Cameron Rink
    Department of Surgery, The Ohio State University Medical Center, 473 W 12th Avenue, Columbus, OH 43210, USA
    J Cereb Blood Flow Metab 30:1275-87. 2010
    ..The findings provide key information relevant to understanding oxygen-dependent molecular mechanisms in the AIS-affected brain...
  62. doi request reprint Evidence-based recommendations for the use of topical oxygen therapy in the treatment of lower extremity wounds
    Gayle M Gordillo
    Division of Plastic Surgery, Department of Surgery, College of Medicine, The Ohio State University, Columbus, Ohio 43210, USA
    Int J Low Extrem Wounds 8:105-11. 2009
    ..Randomized controlled trials are not yet reported and clearly necessary. The current body of evidence suggests that topical oxygen therapy may be considered as a second line of therapy for refractory wounds...
  63. ncbi request reprint Dietary antioxidants for the athlete
    Mustafa Atalay
    512 Davis Heart and Lung Research Institute, 473 West 12th Avenue, The Ohio State University Medical Center, Columbus, OH 43210, USA
    Curr Sports Med Rep 5:182-6. 2006
    ..Overall well being of the athlete, faster recovery, and minimization of injury time could all be affected by antioxidant therapy...
  64. ncbi request reprint DNA microarray technology in nutraceutical and food safety
    Yiwen Liu-Stratton
    Laboratory of Molecular Medicine and DNA Microarray and Genetics Facility, Department of Surgery, Dorothy M Davis Heart and Lung Research Institute, The Ohio State University Medical Center, 473 W 12th Avenue, Columbus, OH 43210, USA
    Toxicol Lett 150:29-42. 2004
    ..Optimization of this technology to specifically address food safety is a vast resource that remains to be mined. Efforts to develop diagnostic custom arrays and simplified bioinformatics tools for field use are warranted...
  65. pmc Vitamin E sensitive genes in the developing rat fetal brain: a high-density oligonucleotide microarray analysis
    Sashwati Roy
    Laboratory of Molecular Medicine, Department of Surgery and Molecular and Cellular Biochemistry, Davis Heart and Lung Research Institute, The Ohio State University Medical Center, 473 W 12th Avenue, Columbus 43210, USA
    FEBS Lett 530:17-23. 2002
    ..The enrichment is more in fetal brain tissue. Using a GeneChip microarray expression profiling approach we have identified a specific set of vitamin E sensitive genes in the developing rat fetal brain...
  66. doi request reprint Characterization of the structural and functional changes in the myocardium following focal ischemia-reperfusion injury
    Navdeep Ojha
    Department of Surgery, Davis Heart and Lung Research Institute, The Ohio State University Medical Center, Columbus, OH, USA
    Am J Physiol Heart Circ Physiol 294:H2435-43. 2008
    ..Myocardial remodeling following I/R includes secondary myocyte death followed by the loss of cardiac function over time...
  67. ncbi request reprint Reactive oxygen species and EGR-1 gene expression in surgical postoperative peritoneal adhesions
    Sashwati Roy
    Department of Surgery, Center for Minimally Invasive Surgery, Laboratory of Molecular Medicine, Davis Heart and Lung Research Institute, The Ohio State University, 473 W 12th Avenue, Columbus, OH 73210, USA
    World J Surg 28:316-20. 2004
    ..The newly developed rodent model of adhesion may present a useful approach to reproducibly and objectively study molecular mechanisms underlying the dynamic process of de novo adhesion tissue formation...
  68. ncbi request reprint Laser microdissection and capture of pure cardiomyocytes and fibroblasts from infarcted heart regions: perceived hyperoxia induces p21 in peri-infarct myocytes
    Donald E Kuhn
    Laboratory of Molecular Medicine, Department of Surgery, Davis Heart and Lung Research Institute, The Ohio State University Medical Center, Columbus, OH 43210, USA
    Am J Physiol Heart Circ Physiol 292:H1245-53. 2007
    ..This work presents the first account of an analytical technique that applies the LMPC technology to study myocardial remodeling with a cell-type specific resolution...
  69. ncbi request reprint Regulation of c-Src activity in glutamate-induced neurodegeneration
    Savita Khanna
    Laboratory of Molecular Medicine, Department of Surgery, Davis Heart and Lung Research Institute, The Ohio State University Medical Center, Columbus, Ohio 43210, USA
    J Biol Chem 282:23482-90. 2007
    ..Findings of this study present a new paradigm that addresses the regulation of c-Src under neurodegenerative conditions...
  70. pmc Oxygen-sensitive reset of hypoxia-inducible factor transactivation response: prolyl hydroxylases tune the biological normoxic set point
    Savita Khanna
    Laboratory of Molecular Medicine, Davis Heart and Lung Research Institute, Department of Surgery, The Ohio State University Medical Center, Columbus, 43210, USA
    Free Radic Biol Med 40:2147-54. 2006
    ..siRNA dependent knockdown of PHD expression revealed that O(2)-sensitive regulation of PHD may contribute to tuning the normoxic set point in biological cells...
  71. pmc Aerobically derived lactate stimulates revascularization and tissue repair via redox mechanisms
    Thomas K Hunt
    Wound Healing Laboratory, University of California San Francisco, San Francisco, California 94143 0522, USA
    Antioxid Redox Signal 9:1115-24. 2007
    ..Accumulated lactate, therefore, appears to convey the impression of "metabolic need" for vascularization, even in well-oxygenated and pH-neutral conditions. Lactate and oxygen together stimulate angiogenesis and matrix deposition...
  72. ncbi request reprint Heat shock protein 60 response to exercise in diabetes: effects of alpha-lipoic acid supplementation
    Niku K J Oksala
    Department of Physiology, University of Kuopio, Finland
    J Diabetes Complications 20:257-61. 2006
    ..Acute exercise increased liver 4-HNE, which was offset by LA. In conclusion, diabetes induced oxidative stress and impaired myocardial HSP60 expression, while LA partially offsets these alterations in a tissue-specific manner...
  73. ncbi request reprint Oxygen: at the foundation of wound healing--introduction
    Thomas K Hunt
    World J Surg 28:291-3. 2004
    ..A historical and evolutionary perspective on the role of oxygen in wound healing--from the classical physiology of oxygen in the wound to the refined concept of redox signaling--is presented...
  74. ncbi request reprint Redox regulation of mitochondrial permeability transition: effects of uncoupler, lipoic acid and its positively charged analog LA-plus and selenium
    Oren Tirosh
    Institute of Biochemistry, Food Science and Nutrition, The Hebrew University of Jerusalem, Rehovot 76100, Israel
    Biofactors 17:297-306. 2003
  75. ncbi request reprint Transcriptome analysis of the ischemia-reperfused remodeling myocardium: temporal changes in inflammation and extracellular matrix
    Sashwati Roy
    Department of Surgery, Davis Heart and Lung Research Institute, The Ohio State University Medical Center, Columbus, Ohio, USA
    Physiol Genomics 25:364-74. 2006
    ..Taken together, this work presents the first evidence gained from the use of DNA microarrays to understand the molecular mechanisms implicated in the early and late inflammatory phases of the I-R heart...
  76. ncbi request reprint Joint International Conference on EPR Spectroscopy and wound healing
    Narasimham L Parinandi
    Center for Biomedical EPR Spectroscopy and Imaging, and Comprehensive Wound Care Center, Davis Heart and Lung Research Institute, The Ohio State University, Columbus, 43210, USA
    Antioxid Redox Signal 8:1385-7. 2006
    ..This should lead to emerging applications of EPR technology in biomedical research and clinical practice...
  77. ncbi request reprint Molecular mechanisms of cardioprotection by a novel grape seed proanthocyanidin extract
    Debasis Bagchi
    Department of Pharmacy Sciences, Medical Center, School of Pharmacy and Creighton University Health Professions, 2500 California Plaza, Omaha, NE 68178, USA
    Mutat Res 523:87-97. 2003
    ..These results demonstrate that GSPE may serve as a potential therapeutic tool in promoting cardiovascular health via a number of novel mechanisms...
  78. ncbi request reprint Alpha-lipoic Acid modulates heat shock factor-1 expression in streptozotocin-induced diabetic rat kidney
    Niku K J Oksala
    Institute of Biomedicine, Physiology, University of Kuopio, Kuopio, Finland
    Antioxid Redox Signal 9:497-506. 2007
    ..However, LA supplementation did not affect these HSPs at the protein level. These findings suggest that in addition to its antiglomerulosclerotic effects, LA can induce cytoprotective response in SID...
  79. ncbi request reprint Relief from a heavy heart: redox-sensitive NF-kappaB as a therapeutic target in managing cardiac hypertrophy
    Chandan K Sen
    Am J Physiol Heart Circ Physiol 289:H17-9. 2005
  80. pmc Tocotrienols in health and disease: the other half of the natural vitamin E family
    Chandan K Sen
    Laboratory of Molecular Medicine, Department of Surgery, Davis Heart and Lung Research Institute, The Ohio State University Medical Center, Columbus, OH 43210, United States
    Mol Aspects Med 28:692-728. 2007
    ..The current state of knowledge warrants strategic investment into investigating the lesser known forms of vitamin E...
  81. ncbi request reprint Significance of oxygen therapeutics
    Gayle M Gordillo
    Wound Repair Regen 11:393; author reply 393. 2003
  82. ncbi request reprint Temperature measurement on tissue surface during laser irradiation
    Surya C Gnyawali
    Department of Physics, Oklahoma State University, Stillwater, OK 74078, USA
    Med Biol Eng Comput 46:159-68. 2008
    ..More importantly, when used with immunotherapy as a precursor of immunological responses, the selective photothermal treatment can be guided by the tissue temperature profiles both in the tumor and on the surface...
  83. pmc Transcriptome-wide analysis of blood vessels laser captured from human skin and chronic wound-edge tissue
    Sashwati Roy
    Comprehensive Wound Center, Department of Surgery, Davis Heart and Lung Research Institute, Ohio State University Medical Center, Columbus, OH 43210, USA
    Proc Natl Acad Sci U S A 104:14472-7. 2007
    ..Sets of genes with known vascular functions but never connected to wound healing were identified to be differentially expressed in wound-derived blood vessels paving the way for innovative clinically relevant hypotheses...