Research Topics
| S S SegalSummaryAffiliation: The John B. Pierce Laboratory Country: USA Publications
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Detail Information
Publications
Role for endothelial cell conduction in ascending vasodilatation and exercise hyperaemia in hamster skeletal muscleS S Segal
The John B Pierce Laboratory and Department of Cellular and Molecular Physiology, Yale University School of Medicine, New Haven, CT 06519, USA
J Physiol 536:937-46. 2001..We propose that this signalling pathway underlies ascending vasodilatation and promotes the full expression of exercise hyperaemia...
Special edition of Microcirculation commemorating the 50th anniversary of the Microcirculatory Society, IncSteven S Segal
The John B Pierce Laboratory, Yale University School of Medicine, New Haven, CT 06519, USA
Microcirculation 12:1-4. 2005....- Spread of vasodilatation and vasoconstriction along feed arteries and arterioles of hamster skeletal muscleS S Segal
The John B Pierce Laboratory and Department of Cellular and Molecular Physiology, Yale University School of Medicine, New Haven, CT 06519, USA
J Physiol 516:283-91. 1999.... - Motor nerve topology reflects myocyte morphology in hamster retractor and epitrochlearis musclesS S Segal
John B Pierce Laboratory, Yale University School of Medicine, New Haven, Connecticut 06519, USA
J Morphol 246:103-17. 2000..epitrochlearis and 100 in m. retractor. Differences in fiber morphology, innervation topology, and neuromuscular organization may contribute to the heterogeneity of metabolic demand and oxygen supply in skeletal muscle... - Regulation of blood flow in the microcirculationSteven S Segal
The John B Pierce Laboratory and Department of Cellular and Molecular Physiology, Yale University School of Medicine, New Haven, CT 06519, USA
Microcirculation 12:33-45. 2005..These pathways are being defined with refreshing new insight as novel approaches are applied to understanding the cellular and molecular mechanisms of blood flow control... - Codistribution of NOS and caveolin throughout peripheral vasculature and skeletal muscle of hamstersS S Segal
The John B Pierce Laboratory, Boyer Center for Molecular Medicine, Yale University School of Medicine, New Haven, Connecticut 06519, USA
Am J Physiol 277:H1167-77. 1999.... - Simulation of motor unit recruitment and microvascular unit perfusion: spatial considerationsA J Fuglevand
John B Pierce Laboratory, Yale University School of Medicine, New Haven, Connecticut 06519, USA
J Appl Physiol 83:1223-34. 1997..Such conditions are similar to those that arise in neuromuscular disorders, with aging, or during electrical stimulation of muscle, respectively... - Direct evidence for the importance of endothelium-derived nitric oxide in vascular remodelingR D Rudic
Department of Pharmacology, Yale University School of Medicine, Boyer Center for Molecular Medicine, New Haven, Connecticut 06536, USA
J Clin Invest 101:731-6. 1998.... - Arteriolar smooth muscle Ca2+ dynamics during blood flow control in hamster cheek pouchJohan Fredrik Brekke
The John B. Pierce Laboratory and Department of Cellular and Molecular Physiology, Yale University School of Medicine, 290 Congress Ave, New Haven, Connecticut 06519, USA
J Appl Physiol 101:307-15. 2006..05), whereas dilation (23 +/- 5 microm) was sustained. Resolution of arteriolar SMC [Ca2+]i in vivo discriminates key signaling events that govern the local control of tissue blood flow... - In response to "Point:Counterpoint: There is/is not capillary recruitment in active skeletal muscle during exercise"Steven S Segal
J Appl Physiol 104:897. 2008 - Sympathetic nerves inhibit conducted vasodilatation along feed arteries during passive stretch of hamster skeletal muscleSara J Haug
The John B. Pierce Laboratory, Department of Cellular and Molecular Physiology, Yale University, 290 Congress Avenue, New Haven, CT 06519, USA
J Physiol 552:273-82. 2003..This autonomic feedback mechanism can restrict muscle blood flow during passive stretch... - Propagated endothelial Ca2+ waves and arteriolar dilation in vivo: measurements in Cx40BAC GCaMP2 transgenic miceYvonne N Tallini
Biomedical Sciences Department, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA
Circ Res 101:1300-9. 2007.... - Electromechanical and pharmacomechanical signalling pathways for conducted vasodilatation along endothelium of hamster feed arteriesTimothy L Domeier
The John B Pierce Laboratory, New Haven, CT 06519, USA
J Physiol 579:175-86. 2007..Thus, ACh triggers electromechanical relaxation of smooth muscle cells along the vessel initiated by local KCa, and the ensuing 'wave' of Ca2+ along the endothelium releases autacoids to promote pharmacomechanical relaxation... - Propagation of calcium waves along endothelium of hamster feed arteriesTorben R Uhrenholt
The John B Pierce Laboratory, Yale University, New Haven, CT, USA
Am J Physiol Heart Circ Physiol 292:H1634-40. 2007..05). Thus Ca(2+) waves propagate along the endothelium of resistance vessels with vasomotor tone, and this signaling pathway is compromised during maximal dilation with nifedipine or SNP... - Conduction of hyperpolarization along hamster feed arteries: augmentation by acetylcholineGeoffrey G Emerson
The John B. Pierce Laboratory and Department of Cellular and Molecular Physiology, Yale University School of Medicine, New Haven, Connecticut 06519, USA
Am J Physiol Heart Circ Physiol 283:H102-9. 2002..9 +/- 0.1 mm, 60% further (P < 0.05) than responses evoked by purely electrical stimuli. These findings indicate that ACh augments the conduction of hyperpolarization along the vessel wall... - Comment on Point:Counterpoint "The muscle pump is/is not an important determinant of muscle blood flow during exercise"Jurgen W G E VanTeeffelen
J Appl Physiol 99:2451. 2005 - Ischemia-reperfusion impairs ascending vasodilation in feed arteries of hamster skeletal muscleMiriam C J de With
The John B Pierce Laboratory and Yale University, New Haven, Connecticut 06519, USA
Microcirculation 12:551-61. 2005..Respective components of endothelial cell signaling events may differ in their susceptibility to I-R... - Abolition of arteriolar dilation but not constriction to histamine in cremaster muscle of eNOS-/- miceGeoffrey W Payne
The John B Pierce Laboratory, Yale University School of Medicine, 290 Congress Avenue, New Haven, CT 06519, USA
Am J Physiol Heart Circ Physiol 285:H493-8. 2003..Thus histamine can increase as well as decrease muscle blood flow, according to local concentration. However, when NO production is compromised, only vasoconstriction and flow reduction occur... - Interaction between sympathetic nerve activation and muscle fibre contraction in resistance vessels of hamster retractor muscleJurgen W G E VanTeeffelen
The John B. Pierce Laboratory and Department of Cellular and Molecular Physiology, Yale University School of Medicine, New Haven, CT 06519, USA
J Physiol 550:563-74. 2003..Such concerted interaction will promote oxygen extraction when blood flow is restricted to maintain arterial pressure... - Microvessels promote motor nerve survival and regeneration through local VEGF release following ectopic reattachmentShawn E Bearden
The John B Pierce Laboratory and Department of Cellular and Molecular Physiology, Yale University School of Medicine, New Haven, Connecticut 06519, USA
Microcirculation 11:633-44. 2004..The authors investigated whether axons would associate with blood vessels in a regenerating system and questioned whether VEGF is integral to neurotization following axotomy... - Arteriolar network architecture and vasomotor function with ageing in mouse gluteus maximus muscleShawn E Bearden
The John B. Pierce Laboratory, Yale University School of Medicine, 290 Congress Ave, New Haven, CT 06519, USA
J Physiol 561:535-45. 2004..05). With arteriolar network architecture maintained during ageing, the impairment in conducted vasodilatation and attenuation of postcontraction vasodilatation may compromise exercise tolerance... - Contribution of active membrane processes to conducted hyperpolarization in arterioles of hamster cheek pouchGlenis J Crane
The John B. Piercy Laboratory, New Haven, Connecticut, USA
Microcirculation 11:425-33. 2004..Signal augmentation will promote blood flow to tissue regions from which hyperpolarization of arterioles originates... - Independence of connexin expression and vasomotor conduction from sympathetic innervation in hamster feed arteriesRobin C Looft-Wilson
The John B. Piercy Laboratory, New Haven, Connecticut 06519, USA
Microcirculation 11:397-408. 2004..05) in denervated vessels. CONCLUSIONS: The profile of connexin expression and the conduction of vasomotor responses are largely independent of sympathetic innervation in feed arteries of the hamster retractor muscle (RFA)... - Homocellular conduction along endothelium and smooth muscle of arterioles in hamster cheek pouch: unmasking an NO waveStephane Budel
The John B Pierce Laboratory, Yale University School of Medicine, 290 Congress Ave, New Haven, Conn 06519 1403, USA
Circ Res 93:61-8. 2003..Thus, conduction of vasodilation entails a wave of NO release along arteriolar endothelium that is masked when smooth muscle provides a parallel conduction pathway... - Histamine inhibits conducted vasodilation through endothelium-derived NO production in arterioles of mouse skeletal muscleGeoffrey W Payne
The John B Pierce Laboratory, Yale University School of Medicine, New Haven, Connecticut 06519, USA
FASEB J 18:280-6. 2004..These findings indicate that histamine inhibits cell-to-cell coupling through an NO-dependent mechanism and suggests a dynamic interaction among intercellular adhesion molecules and gap junction channels along arteriolar endothelium... - Expression of homocellular and heterocellular gap junctions in hamster arterioles and feed arteriesShaun L Sandow
Division of Neuroscience, John Curtin School of Medical Research, Australian National University, ACT 0200 Canberra, Australia
Cardiovasc Res 60:643-53. 2003.... - Connexin expression and conducted vasodilation along arteriolar endothelium in mouse skeletal muscleRobin C Looft-Wilson
The John B. Pierce Laboratory, Yale University School of Medicine, New Haven, Connecticut 06519, USA
J Appl Physiol 97:1152-8. 2004..We conclude that vasodilation is conducted along the endothelium of mouse skeletal muscle arterioles and that connexin40 and connexin37 are the primary connexins forming gap junction channels between arteriolar endothelial cells...