S S Segal

Summary

Affiliation: The John B. Pierce Laboratory
Country: USA

Publications

  1. pmc Role for endothelial cell conduction in ascending vasodilatation and exercise hyperaemia in hamster skeletal muscle
    S S Segal
    The John B Pierce Laboratory and Department of Cellular and Molecular Physiology, Yale University School of Medicine, New Haven, CT 06519, USA
    J Physiol 536:937-46. 2001
  2. ncbi request reprint Special edition of Microcirculation commemorating the 50th anniversary of the Microcirculatory Society, Inc
    Steven S Segal
    The John B Pierce Laboratory, Yale University School of Medicine, New Haven, CT 06519, USA
    Microcirculation 12:1-4. 2005
  3. pmc Spread of vasodilatation and vasoconstriction along feed arteries and arterioles of hamster skeletal muscle
    S S Segal
    The John B Pierce Laboratory and Department of Cellular and Molecular Physiology, Yale University School of Medicine, New Haven, CT 06519, USA
    J Physiol 516:283-91. 1999
  4. ncbi request reprint Motor nerve topology reflects myocyte morphology in hamster retractor and epitrochlearis muscles
    S S Segal
    John B Pierce Laboratory, Yale University School of Medicine, New Haven, Connecticut 06519, USA
    J Morphol 246:103-17. 2000
  5. ncbi request reprint Regulation of blood flow in the microcirculation
    Steven S Segal
    The John B Pierce Laboratory and Department of Cellular and Molecular Physiology, Yale University School of Medicine, New Haven, CT 06519, USA
    Microcirculation 12:33-45. 2005
  6. ncbi request reprint Codistribution of NOS and caveolin throughout peripheral vasculature and skeletal muscle of hamsters
    S S Segal
    The John B Pierce Laboratory, Boyer Center for Molecular Medicine, Yale University School of Medicine, New Haven, Connecticut 06519, USA
    Am J Physiol 277:H1167-77. 1999
  7. ncbi request reprint Simulation of motor unit recruitment and microvascular unit perfusion: spatial considerations
    A J Fuglevand
    John B Pierce Laboratory, Yale University School of Medicine, New Haven, Connecticut 06519, USA
    J Appl Physiol 83:1223-34. 1997
  8. pmc Direct evidence for the importance of endothelium-derived nitric oxide in vascular remodeling
    R D Rudic
    Department of Pharmacology, Yale University School of Medicine, Boyer Center for Molecular Medicine, New Haven, Connecticut 06536, USA
    J Clin Invest 101:731-6. 1998
  9. ncbi request reprint Arteriolar smooth muscle Ca2+ dynamics during blood flow control in hamster cheek pouch
    Johan Fredrik Brekke
    The John B Pierce Laboratory and Department of Cellular and Molecular Physiology, Yale University School of Medicine, 290 Congress Ave, New Haven, Connecticut 06519, USA
    J Appl Physiol 101:307-15. 2006
  10. ncbi request reprint In response to "Point:Counterpoint: There is/is not capillary recruitment in active skeletal muscle during exercise"
    Steven S Segal
    J Appl Physiol 104:897. 2008

Collaborators

Detail Information

Publications27

  1. pmc Role for endothelial cell conduction in ascending vasodilatation and exercise hyperaemia in hamster skeletal muscle
    S S Segal
    The John B Pierce Laboratory and Department of Cellular and Molecular Physiology, Yale University School of Medicine, New Haven, CT 06519, USA
    J Physiol 536:937-46. 2001
    ..We propose that this signalling pathway underlies ascending vasodilatation and promotes the full expression of exercise hyperaemia...
  2. ncbi request reprint Special edition of Microcirculation commemorating the 50th anniversary of the Microcirculatory Society, Inc
    Steven S Segal
    The John B Pierce Laboratory, Yale University School of Medicine, New Haven, CT 06519, USA
    Microcirculation 12:1-4. 2005
    ....
  3. pmc Spread of vasodilatation and vasoconstriction along feed arteries and arterioles of hamster skeletal muscle
    S S Segal
    The John B Pierce Laboratory and Department of Cellular and Molecular Physiology, Yale University School of Medicine, New Haven, CT 06519, USA
    J Physiol 516:283-91. 1999
    ....
  4. ncbi request reprint Motor nerve topology reflects myocyte morphology in hamster retractor and epitrochlearis muscles
    S S Segal
    John B Pierce Laboratory, Yale University School of Medicine, New Haven, Connecticut 06519, USA
    J Morphol 246:103-17. 2000
    ..epitrochlearis and 100 in m. retractor. Differences in fiber morphology, innervation topology, and neuromuscular organization may contribute to the heterogeneity of metabolic demand and oxygen supply in skeletal muscle...
  5. ncbi request reprint Regulation of blood flow in the microcirculation
    Steven S Segal
    The John B Pierce Laboratory and Department of Cellular and Molecular Physiology, Yale University School of Medicine, New Haven, CT 06519, USA
    Microcirculation 12:33-45. 2005
    ..These pathways are being defined with refreshing new insight as novel approaches are applied to understanding the cellular and molecular mechanisms of blood flow control...
  6. ncbi request reprint Codistribution of NOS and caveolin throughout peripheral vasculature and skeletal muscle of hamsters
    S S Segal
    The John B Pierce Laboratory, Boyer Center for Molecular Medicine, Yale University School of Medicine, New Haven, Connecticut 06519, USA
    Am J Physiol 277:H1167-77. 1999
    ....
  7. ncbi request reprint Simulation of motor unit recruitment and microvascular unit perfusion: spatial considerations
    A J Fuglevand
    John B Pierce Laboratory, Yale University School of Medicine, New Haven, Connecticut 06519, USA
    J Appl Physiol 83:1223-34. 1997
    ..Such conditions are similar to those that arise in neuromuscular disorders, with aging, or during electrical stimulation of muscle, respectively...
  8. pmc Direct evidence for the importance of endothelium-derived nitric oxide in vascular remodeling
    R D Rudic
    Department of Pharmacology, Yale University School of Medicine, Boyer Center for Molecular Medicine, New Haven, Connecticut 06536, USA
    J Clin Invest 101:731-6. 1998
    ....
  9. ncbi request reprint Arteriolar smooth muscle Ca2+ dynamics during blood flow control in hamster cheek pouch
    Johan Fredrik Brekke
    The John B Pierce Laboratory and Department of Cellular and Molecular Physiology, Yale University School of Medicine, 290 Congress Ave, New Haven, Connecticut 06519, USA
    J Appl Physiol 101:307-15. 2006
    ..05), whereas dilation (23 +/- 5 microm) was sustained. Resolution of arteriolar SMC [Ca2+]i in vivo discriminates key signaling events that govern the local control of tissue blood flow...
  10. ncbi request reprint In response to "Point:Counterpoint: There is/is not capillary recruitment in active skeletal muscle during exercise"
    Steven S Segal
    J Appl Physiol 104:897. 2008
  11. pmc Sympathetic nerves inhibit conducted vasodilatation along feed arteries during passive stretch of hamster skeletal muscle
    Sara J Haug
    The John B Pierce Laboratory, Department of Cellular and Molecular Physiology, Yale University, 290 Congress Avenue, New Haven, CT 06519, USA
    J Physiol 552:273-82. 2003
    ..This autonomic feedback mechanism can restrict muscle blood flow during passive stretch...
  12. ncbi request reprint Propagated endothelial Ca2+ waves and arteriolar dilation in vivo: measurements in Cx40BAC GCaMP2 transgenic mice
    Yvonne N Tallini
    Biomedical Sciences Department, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA
    Circ Res 101:1300-9. 2007
    ....
  13. pmc Electromechanical and pharmacomechanical signalling pathways for conducted vasodilatation along endothelium of hamster feed arteries
    Timothy L Domeier
    The John B Pierce Laboratory, New Haven, CT 06519, USA
    J Physiol 579:175-86. 2007
    ..Thus, ACh triggers electromechanical relaxation of smooth muscle cells along the vessel initiated by local KCa, and the ensuing 'wave' of Ca2+ along the endothelium releases autacoids to promote pharmacomechanical relaxation...
  14. ncbi request reprint Propagation of calcium waves along endothelium of hamster feed arteries
    Torben R Uhrenholt
    The John B Pierce Laboratory, Yale University, New Haven, CT, USA
    Am J Physiol Heart Circ Physiol 292:H1634-40. 2007
    ..05). Thus Ca(2+) waves propagate along the endothelium of resistance vessels with vasomotor tone, and this signaling pathway is compromised during maximal dilation with nifedipine or SNP...
  15. ncbi request reprint Conduction of hyperpolarization along hamster feed arteries: augmentation by acetylcholine
    Geoffrey G Emerson
    The John B Pierce Laboratory and Department of Cellular and Molecular Physiology, Yale University School of Medicine, New Haven, Connecticut 06519, USA
    Am J Physiol Heart Circ Physiol 283:H102-9. 2002
    ..9 +/- 0.1 mm, 60% further (P < 0.05) than responses evoked by purely electrical stimuli. These findings indicate that ACh augments the conduction of hyperpolarization along the vessel wall...
  16. ncbi request reprint Comment on Point:Counterpoint "The muscle pump is/is not an important determinant of muscle blood flow during exercise"
    Jurgen W G E VanTeeffelen
    J Appl Physiol 99:2451. 2005
  17. ncbi request reprint Ischemia-reperfusion impairs ascending vasodilation in feed arteries of hamster skeletal muscle
    Miriam C J de With
    The John B Pierce Laboratory and Yale University, New Haven, Connecticut 06519, USA
    Microcirculation 12:551-61. 2005
    ..Whereas ischemia-reperfusion (I-R) can affect endothelial cell function, the effect of I-R on AVD is unknown. The authors tested the hypothesis that I-R (1h-1h) would impair AVD...
  18. ncbi request reprint Abolition of arteriolar dilation but not constriction to histamine in cremaster muscle of eNOS-/- mice
    Geoffrey W Payne
    The John B Pierce Laboratory, Yale University School of Medicine, 290 Congress Avenue, New Haven, CT 06519, USA
    Am J Physiol Heart Circ Physiol 285:H493-8. 2003
    ..Thus histamine can increase as well as decrease muscle blood flow, according to local concentration. However, when NO production is compromised, only vasoconstriction and flow reduction occur...
  19. pmc Interaction between sympathetic nerve activation and muscle fibre contraction in resistance vessels of hamster retractor muscle
    Jurgen W G E VanTeeffelen
    The John B Pierce Laboratory and Department of Cellular and Molecular Physiology, Yale University School of Medicine, New Haven, CT 06519, USA
    J Physiol 550:563-74. 2003
    ..Such concerted interaction will promote oxygen extraction when blood flow is restricted to maintain arterial pressure...
  20. ncbi request reprint Microvessels promote motor nerve survival and regeneration through local VEGF release following ectopic reattachment
    Shawn E Bearden
    The John B Pierce Laboratory and Department of Cellular and Molecular Physiology, Yale University School of Medicine, New Haven, Connecticut 06519, USA
    Microcirculation 11:633-44. 2004
    ..The authors investigated whether axons would associate with blood vessels in a regenerating system and questioned whether VEGF is integral to neurotization following axotomy...
  21. pmc Arteriolar network architecture and vasomotor function with ageing in mouse gluteus maximus muscle
    Shawn E Bearden
    The John B Pierce Laboratory, Yale University School of Medicine, 290 Congress Ave, New Haven, CT 06519, USA
    J Physiol 561:535-45. 2004
    ..05). With arteriolar network architecture maintained during ageing, the impairment in conducted vasodilatation and attenuation of postcontraction vasodilatation may compromise exercise tolerance...
  22. ncbi request reprint Contribution of active membrane processes to conducted hyperpolarization in arterioles of hamster cheek pouch
    Glenis J Crane
    The John B Piercy Laboratory, New Haven, Connecticut, USA
    Microcirculation 11:425-33. 2004
    ..The authors tested the hypothesis that the conduction of hyperpolarization involves active membrane processes as the signal travels along the arteriolar wall...
  23. ncbi request reprint Independence of connexin expression and vasomotor conduction from sympathetic innervation in hamster feed arteries
    Robin C Looft-Wilson
    The John B Piercy Laboratory, New Haven, Connecticut 06519, USA
    Microcirculation 11:397-408. 2004
    ..In feed arteries of the hamster retractor muscle (RFA), the authors tested whether sympathetic denervation would alter the expression of connexin isoforms and the conduction of vasomotor responses...
  24. ncbi request reprint Homocellular conduction along endothelium and smooth muscle of arterioles in hamster cheek pouch: unmasking an NO wave
    Stephane Budel
    The John B Pierce Laboratory, Yale University School of Medicine, 290 Congress Ave, New Haven, Conn 06519 1403, USA
    Circ Res 93:61-8. 2003
    ..Thus, conduction of vasodilation entails a wave of NO release along arteriolar endothelium that is masked when smooth muscle provides a parallel conduction pathway...
  25. ncbi request reprint Histamine inhibits conducted vasodilation through endothelium-derived NO production in arterioles of mouse skeletal muscle
    Geoffrey W Payne
    The John B Pierce Laboratory, Yale University School of Medicine, New Haven, Connecticut 06519, USA
    FASEB J 18:280-6. 2004
    ..These findings indicate that histamine inhibits cell-to-cell coupling through an NO-dependent mechanism and suggests a dynamic interaction among intercellular adhesion molecules and gap junction channels along arteriolar endothelium...
  26. ncbi request reprint Expression of homocellular and heterocellular gap junctions in hamster arterioles and feed arteries
    Shaun L Sandow
    Division of Neuroscience, John Curtin School of Medical Research, Australian National University, ACT 0200 Canberra, Australia
    Cardiovasc Res 60:643-53. 2003
    ....
  27. ncbi request reprint Connexin expression and conducted vasodilation along arteriolar endothelium in mouse skeletal muscle
    Robin C Looft-Wilson
    The John B Pierce Laboratory, Yale University School of Medicine, New Haven, Connecticut 06519, USA
    J Appl Physiol 97:1152-8. 2004
    ..We conclude that vasodilation is conducted along the endothelium of mouse skeletal muscle arterioles and that connexin40 and connexin37 are the primary connexins forming gap junction channels between arteriolar endothelial cells...