Research Topics
Genomes and GenesSpecies | M A SchwartzSummaryAffiliation: The Scripps Research Institute Country: USA Publications
| Collaborators
|
Detail Information
Publications
Interactions between mitogenic stimuli, or, a thousand and one connectionsM A Schwartz
Department of Vascular Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
Curr Opin Cell Biol 11:197-202. 1999..These interactions enable cells to integrate information from multiple stimuli that regulate cell cycle progression...- Integrin signaling revisitedM A Schwartz
Dept of Vascular Biology, Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
Trends Cell Biol 11:466-70. 2001..Most striking is the merger with studies of other receptors, the cytoskeleton and mechanical forces within the general field of signaling networks... - Integrins and cell proliferation: regulation of cyclin-dependent kinases via cytoplasmic signaling pathwaysM A Schwartz
Department of Vascular Biology, The Scripps Research Institute, La Jolla, CA 92037, USA
J Cell Sci 114:2553-60. 2001..Regulation of cyclin D1 by the ERK pathway may provide a paradigm for understanding how cell adhesion can determine cell cycle progression... - Networks and crosstalk: integrin signalling spreadsMartin A Schwartz
Division of Vascular Biology, Department of Cell Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, USA
Nat Cell Biol 4:E65-8. 2002..We discuss how adhesive signalling is coordinately regulated through intersecting networks. We also examine some examples of how some forms of integrin crosstalk may lead to unforeseen and potentially deleterious responses... - Signaling networks linking integrins and rho family GTPasesM A Schwartz
Dept of Vascular Biology, The Scripps Research Institute, La Jolla, CA 92037, USA
Trends Biochem Sci 25:388-91. 2000..Recently, it has also become apparent that integrins regulate Rho GTPases and vice versa. Integrins and GTPases might therefore be organized into complex signaling cascades that regulate cell behavior... 
Integrin-mediated mechanotransduction requires its dynamic interaction with specific extracellular matrix (ECM) ligandsS Jalali
Department of Bioengineering and The Whitaker Institute of Biomedical Engineering, University of California, San Diego, La Jolla, CA 92093-0427, USA
Proc Natl Acad Sci U S A 98:1042-6. 2001..Our results indicate that the dynamic formation of new connections between integrins and their specific ECM ligands is critical in relaying the signals induced by shear stress to intracellular pathways...- Death effector domain protein PEA-15 potentiates Ras activation of extracellular signal receptor-activated kinase by an adhesion-independent mechanismJ W Ramos
Department of Vascular Biology, The Scripps Research Institute, La Jolla, California 92037, USA
Mol Biol Cell 11:2863-72. 2000..In contrast, the DED of PEA-15 is essential for its capacity to activate ERK. The ability of PEA-15 to simultaneously inhibit apoptosis and potentiate Ras-to-Erk signaling may be of importance for oncogenic processes... - Activation of integrins in endothelial cells by fluid shear stress mediates Rho-dependent cytoskeletal alignmentE Tzima
Department of Vascular Biology, The Scripps Research Institute, 10550 N.Torrey Pines Road, La Jolla, CA 92037, USA
EMBO J 20:4639-47. 2001..This transient inhibition is necessary for cytoskeletal alignment in the direction of flow. The results therefore define the role of integrins and Rho in a pathway leading to endothelial cell adaptation to flow... - Increased filamin binding to beta-integrin cytoplasmic domains inhibits cell migrationD A Calderwood
Department of Vascular Biology, The Scripps Research Institute, 10550 N Torrey Pines Rd, La Jolla, California 92037, USA
Nat Cell Biol 3:1060-8. 2001..Thus, tight filamin binding restricts integrin-dependent cell migration by inhibiting transient membrane protrusion and cell polarization... - Rac recruits high-affinity integrin alphavbeta3 to lamellipodia in endothelial cell migrationW B Kiosses
Department of Vascular Biology, 10550 North Torrey Pines Road, La Jolla, California 92037, USA
Nat Cell Biol 3:316-20. 2001..By using WOW-1, we have identified the selective recruitment of high-affinity integrins as a mechanism by which lamellipodia promote formation of new adhesions at the leading edge in cell migration... - c-Abl tyrosine kinase binds and phosphorylates phospholipid scramblase 1J Sun
Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, California 92037, USA
J Biol Chem 276:28984-90. 2001..These findings indicate that c-Abl binds and phosphorylates PLSCR1, and raise the possibility that an interaction between c-Abl and plasma membrane PLSCR1 might contribute to the cellular response to genotoxic stress... - Insulin-like growth factor receptor cooperates with integrin alpha v beta 5 to promote tumor cell dissemination in vivoP C Brooks
Department of Immunology, Scripps Research Institute, La Jolla, California 92037, USA
J Clin Invest 99:1390-8. 1997..These findings provide evidence that integrin ligation, in conjunction with cytokine activation, plays an important role in the dissemination of malignant tumor cells... - Biologically active fragment of a human tRNA synthetase inhibits fluid shear stress-activated responses of endothelial cellsE Tzima
Department of Molecular Biology, The Scripps Research Institute, La Jolla, CA 92037, USA
Proc Natl Acad Sci U S A 100:14903-7. 2003..Thus, this biological fragment of TrpRS may have a role in the maintenance of vascular homeostasis... 
Affinity modulation of platelet integrin alphaIIbbeta3 by beta3-endonexin, a selective binding partner of the beta3 integrin cytoplasmic tailH Kashiwagi
Department of Vascular Biology, The Scripps Research Institute, La Jolla, California 92037, USA
J Cell Biol 137:1433-43. 1997..By analogy, the adhesive function of platelets may be regulated by such protein-protein interactions at the level of the cytoplasmic tails of alphaIIbbeta3...- Integrins regulate the association and phosphorylation of paxillin by c-AblJ M Lewis
Department of Vascular Biology, The Scripps Research Institute, La Jolla, California 92037, USA
J Biol Chem 273:14225-30. 1998..In addition, paxillin was found to serve as substrate for the adhesion-activated c-Abl kinase. These results suggest that c-Abl may mediate effects of integrins on cell functions by phosphorylating paxillin... - Differential alphav integrin-mediated Ras-ERK signaling during two pathways of angiogenesisJohn D Hood
Department of Immunology, The Scripps Research Institute, La Jolla, CA 92037, USA
J Cell Biol 162:933-43. 2003..Thus, integrins alphavbeta3 and alphavbeta5 differentially regulate the Ras-ERK pathway, accounting for distinct vascular responses during two pathways of angiogenesis... - Integrins regulate Rac targeting by internalization of membrane domainsMiguel A Del Pozo
Department of Cell Biology, Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
Science 303:839-42. 2004..Regulation of lipid rafts by integrin signals may regulate the location of membrane domains such as lipid rafts and thereby control domain-specific signaling events in anchorage-dependent cells... - Rho mediates the shear-enhancement of endothelial cell migration and traction force generationYan-Ting Shiu
Department of Bioengineering and The Whitaker Institute of Biomedical Engineering, University of California at San Diego, La Jolla, California 92093-0427, USA
Biophys J 86:2558-65. 2004..Our results indicate that shear stress enhances the migration speed of endothelial cells by modulating the biophysical force of tractions through the biochemical pathway of Rho-p160ROCK... - VE-cadherin links tRNA synthetase cytokine to anti-angiogenic functionEleni Tzima
Skaggs Institute for Chemical Biology, Department of Chemistry and Molecular Biology, The Scripps Research Institute, La Jolla, California 92037, USA
J Biol Chem 280:2405-8. 2005..Binding of T2-TrpRS inhibited VEGF-induced ERK activation and EC migration. Thus, a VE-cadherin-dependent pathway is proposed to link T2-TrpRS to inhibition of new blood vessel formation... - Guanine exchange-dependent and -independent effects of Vav1 on integrin-induced T cell spreadingMiguel Angel del Pozo
Division of Cell Biology, La Jolla Institute for Allergy and Immunology, San Diego, CA 92121, USA
J Immunol 170:41-7. 2003..In contrast, a point mutation in the SH2 domain of Vav1 abolished this synergistic effect. Therefore, our results suggest a new regulatory effect of Vav1 in T cell spreading, which is independent of its guanine exchange factor activity... - A fragment of paxillin binds the alpha 4 integrin cytoplasmic domain (tail) and selectively inhibits alpha 4-mediated cell migrationShouchun Liu
Department of Vascular Biology and Cell Biology, The Scripps Research Institute, La Jolla, California 92037, USA
J Biol Chem 277:20887-94. 2002..Thus, paxillin binding to the alpha(4) tail leads to enhanced cell migration and inhibition of the alpha(4)-paxillin interaction selectively blocks the alpha4-dependent cellular responses... - Localized Rac activation dynamics visualized in living cellsV S Kraynov
Department of Cell Biology, The Scripps Research Institute, La Jolla, CA 92037, USA
Science 290:333-7. 2000..FLAIR exemplifies a generally applicable approach for examining spatio-temporal control of protein activity... - Suppression of integrin activation: a novel function of a Ras/Raf-initiated MAP kinase pathwayP E Hughes
Department of Vascular Biology, The Scripps Research Institute, La Jolla, California 92037, USA
Cell 88:521-30. 1997..Thus, regulation of integrin affinity state is a novel, transcription-independent function of a Ras-linked MAP kinase pathway that may mediate a negative feedback loop in integrin function... - Zizimin1, a novel Cdc42 activator, reveals a new GEF domain for Rho proteinsNahum Meller
Division of Vascular Biology, Department of Cell Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla CA 92037, USA
Nat Cell Biol 4:639-47. 2002..CZH2-containing proteins constitute a new superfamily that includes the so-called 'CDM' proteins that bind to and activate Rac. Together, the results suggest that CZH2 is a new GEF domain for the Rho family of proteins... - Integrin-dependent actomyosin contraction regulates epithelial cell scatteringJohan de Rooij
Department of Cell Biology, The Scripps Research Institute, La Jolla, CA 92037, USA
J Cell Biol 171:153-64. 2005..We conclude that integrin-dependent actomyosin traction force mediates the disruption of cell-cell adhesion during epithelial cell scattering... - Regulation of inositol lipid kinases by Rho and RacX D Ren
Department of Vascular Biology, Scripps Research Institute, La Jolla, California 92037, USA
Curr Opin Genet Dev 8:63-7. 1998..Rho family GTPases also interact with phosphatidylinositol 3-kinase, though this kinase can be either upstream or downstream of the GTPases depending upon the system... - Matrix and meaningMartin A Schwartz
Scripps Research Institute, Department of Vascular Biology, La Jolla, California 92037, USA
Methods Cell Biol 69:13-6. 2002 - In vivo dynamics of Rac-membrane interactionsKonstadinos Moissoglu
Cardiovascular Research Center, University of Virginia, Charlottesville, VA 22908, USA
Mol Biol Cell 17:2770-9. 2006..These results indicate that RhoGDI controls Rac function mainly through effects on activation and/or membrane association... - Integrating adhesion, protrusion, and contraction during cell migrationMartin A Schwartz
Department of Microbiology, University of Virginia School of Medicine, Charlottesville, VA 22908, USA
Cell 125:1223-5. 2006..In this issue of Cell, reveal how adhesion and cytoskeletal dynamics are integrated to optimize migration speed... - Matrix-specific suppression of integrin activation in shear stress signalingA Wayne Orr
Department of Microbiology, University of Virginia, Charlottesville, VA 22908, USA
Mol Biol Cell 17:4686-97. 2006..Thus, integrins actively cross-inhibit through specific kinase pathways. These mechanisms may determine cellular responses to complex extracellular matrices... - Rac, membrane heterogeneity, caveolin and regulation of growth by integrinsMiguel A Del Pozo
Integrin Signalling Laboratory, Centro Nacional de Investigaciones Cardiovasculares, Melchor Fernandez Almagro 3, Madrid, Spain
Trends Cell Biol 17:246-50. 2007..This mechanism can account for the control of multiple pathways by integrins, thus providing an important mechanism for anchorage dependence of growth... - A fluorescence resonance energy transfer activation sensor for Arf6Brian Hall
Robert M Berne Cardiovascular Research Center, University of Virginia, Charlottesville, VA 22908, USA
Anal Biochem 374:243-9. 2008..The addition of platelet-derived growth factor (PDGF) to fibroblasts triggered a rapid and transient increase in FRET, indicative of Arf6 activation. These reagents should be useful for investigations of Arf6 activation and function... - Function of the N-terminus of zizimin1: autoinhibition and membrane targetingNahum Meller
Cardiovascular Research Center, University of Virginia, Charlottesville, VA 22908, USA
Biochem J 409:525-33. 2008..The N-terminal PH (pleckstrin homology) domain binds phosphoinositides and mediates zizimin1 membrane targeting. These results define two novel functions for the N-terminal region of zizimin1... - Blocking p21-activated kinase reduces lipopolysaccharide-induced acute lung injury by preventing polymorphonuclear leukocyte infiltrationJörg Reutershan
Robert M Berne Cardiovascular Research Center, University of Virginia, Charlottesville, VA 22908 1394, USA
Am J Respir Crit Care Med 175:1027-35. 2007..p21-Activated kinase (PAK) is an effector of small GTPases and has been implicated in cell migration... - Integrin-mediated adhesion regulates membrane orderKatharina Gaus
Centre for Vascular Research, School of Medical Sciences, University of New South Wales, Sydney, 2052 NSW, Australia
J Cell Biol 174:725-34. 2006..These results show that lipid raft properties are conferred by assembly of specific protein complexes. The ordered state within focal adhesions may have important consequences for signaling at these sites... - 12/15-lipoxygenase regulates intercellular adhesion molecule-1 expression and monocyte adhesion to endothelium through activation of RhoA and nuclear factor-kappaBDavid T Bolick
Cardiovascular Research Center, University of Virginia, Charlottesville, VA 22908, USA
Arterioscler Thromb Vasc Biol 25:2301-7. 2005..These findings identify a major signaling pathway in EC through which 12/15-LO contributes to vascular inflammation and atherosclerosis... - Phospho-caveolin-1 mediates integrin-regulated membrane domain internalizationMiguel A Del Pozo
Centro Nacional de Investigaciones Cardiovasculares CNIC, Madrid 28029, Spain
Nat Cell Biol 7:901-8. 2005..These data define a novel molecular mechanism for growth and tumour suppression by caveolin-1... - Cell adhesion receptors in mechanotransductionMartin A Schwartz
Department of Microbiology and Biomedical Engineering, Cardiovascular Research Center and Mellon Urological Cancer Research Institute, University of Virginia Charlottesville, VA 22908, USA
Curr Opin Cell Biol 20:551-6. 2008..Studies of developing organisms suggest that these mechanisms contribute to tissue level responses to tension and compression, thereby linking morphogenetic movements to cell fate decisions... - Rho-ROCK-LIMK-cofilin pathway regulates shear stress activation of sterol regulatory element binding proteinsTong Lin
Division of Biomedical Sciences, University of California, Riverside, Riverside, Calif 92521-0121, USA
Circ Res 92:1296-304. 2003..By enhancing the SREBP-mediated cholesterol metabolism, this unique mechanism may contribute to endothelial cell functions under flow... - Zizimin2: a novel, DOCK180-related Cdc42 guanine nucleotide exchange factor expressed predominantly in lymphocytesAkihiko Nishikimi
Laboratory of Experimental Animal Model Research, National Institute for Longevity Sciences, National Center for Geriatrics and Gerontology, 36 3, Gengo, Morioka cho, Obu City, Aichi 474 8522, Japan
FEBS Lett 579:1039-46. 2005..Their tissue distributions are distinct, however, with zizimin2 expressed predominantly in lymphocytes and an opposite pattern for zizimin1. Zizimin3 was also analyzed and showed distinct GTPase specificity and tissue distribution... - Cell migration: integrating signals from front to backAnne J Ridley
Ludwig Institute for Cancer Research, Royal Free and University College School of Medicine, London W1W 7BS, UK
Science 302:1704-9. 2003.... - The intermediate S1' pocket of the endometase/matrilysin-2 active site revealed by enzyme inhibition kinetic studies, protein sequence analyses, and homology modelingHyun I Park
Department of Chemistry and Biochemistry and Institute of Molecular Biophysics, Florida State University, Tallahassee, Florida 32306 4390, USA
J Biol Chem 278:51646-53. 2003.... - Catalytic- and ecto-domains of membrane type 1-matrix metalloproteinase have similar inhibition profiles but distinct endopeptidase activitiesDouglas R Hurst
Department of Chemistry and Biochemistry and Institute of Molecular Biophysics, 203 Dittmer Laboratory of Chemistry Building, Florida State University, Tallahassee, FL 32306, U.S.A
Biochem J 377:775-9. 2004..Ratios of K (i) values for the inhibitor pairs were found to correlate between the enzyme forms with a slope of 1.03, suggesting that the haemopexin domain does not significantly modify the enzyme active-site structure... - Enzymatic properties of rat myelencephalon-specific proteaseSachiko I Blaber
Institute of Molecular Biophysics, Florida State University, Tallahassee, Florida 32306 4380, USA
Biochemistry 41:1165-73. 2002.... - Rho proteins in cell migration and metastasisBrian Titus
Department of Molecular Physiology and Biological Physics, University of Virginia, Charlottesville, USA
Crit Rev Eukaryot Gene Expr 15:103-14. 2005..The aim of this review is to examine the fundamental role of migration in cancer progression and to discuss the role of the Rho family of small G proteins and their effectors in this process... - Inhibition of enzyme activity of and cell-mediated substrate cleavage by membrane type 1 matrix metalloproteinase by newly developed mercaptosulphide inhibitorsDouglas R Hurst
Department of Chemistry and Biochemistry and Institute of Molecular Biophysics, Florida State University, Tallahassee, FL 32306-4390, USA
Biochem J 392:527-36. 2005..These results provide a model for mercaptosulphide inhibitor binding to MT1-MMP that may aid in the design of more potent and selective inhibitors for MT1-MMP...