M A Schwartz

Summary

Affiliation: The Scripps Research Institute
Country: USA

Publications

  1. ncbi request reprint Integrin signaling revisited
    M A Schwartz
    Dept of Vascular Biology, Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Trends Cell Biol 11:466-70. 2001
  2. ncbi request reprint Integrins and cell proliferation: regulation of cyclin-dependent kinases via cytoplasmic signaling pathways
    M A Schwartz
    Department of Vascular Biology, The Scripps Research Institute, La Jolla, CA 92037, USA
    J Cell Sci 114:2553-60. 2001
  3. ncbi request reprint Networks and crosstalk: integrin signalling spreads
    Martin A Schwartz
    Division of Vascular Biology, Department of Cell Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, USA
    Nat Cell Biol 4:E65-8. 2002
  4. ncbi request reprint Signaling networks linking integrins and rho family GTPases
    M A Schwartz
    Dept of Vascular Biology, The Scripps Research Institute, La Jolla, CA 92037, USA
    Trends Biochem Sci 25:388-91. 2000
  5. ncbi request reprint Interactions between mitogenic stimuli, or, a thousand and one connections
    M A Schwartz
    Department of Vascular Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Curr Opin Cell Biol 11:197-202. 1999
  6. pmc Integrin-mediated mechanotransduction requires its dynamic interaction with specific extracellular matrix (ECM) ligands
    S Jalali
    Department of Bioengineering and The Whitaker Institute of Biomedical Engineering, University of California, San Diego, La Jolla, CA 92093-0427, USA
    Proc Natl Acad Sci U S A 98:1042-6. 2001
  7. pmc Death effector domain protein PEA-15 potentiates Ras activation of extracellular signal receptor-activated kinase by an adhesion-independent mechanism
    J W Ramos
    Department of Vascular Biology, The Scripps Research Institute, La Jolla, California 92037, USA
    Mol Biol Cell 11:2863-72. 2000
  8. ncbi request reprint Increased filamin binding to beta-integrin cytoplasmic domains inhibits cell migration
    D A Calderwood
    Department of Vascular Biology, The Scripps Research Institute, 10550 N Torrey Pines Rd, La Jolla, California 92037, USA
    Nat Cell Biol 3:1060-8. 2001
  9. pmc Activation of integrins in endothelial cells by fluid shear stress mediates Rho-dependent cytoskeletal alignment
    E Tzima
    Department of Vascular Biology, The Scripps Research Institute, 10550 N.Torrey Pines Road, La Jolla, CA 92037, USA
    EMBO J 20:4639-47. 2001
  10. ncbi request reprint Rac recruits high-affinity integrin alphavbeta3 to lamellipodia in endothelial cell migration
    W B Kiosses
    Department of Vascular Biology, 10550 North Torrey Pines Road, La Jolla, California 92037, USA
    Nat Cell Biol 3:316-20. 2001

Collaborators

Detail Information

Publications47

  1. ncbi request reprint Integrin signaling revisited
    M A Schwartz
    Dept of Vascular Biology, Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Trends Cell Biol 11:466-70. 2001
    ..Most striking is the merger with studies of other receptors, the cytoskeleton and mechanical forces within the general field of signaling networks...
  2. ncbi request reprint Integrins and cell proliferation: regulation of cyclin-dependent kinases via cytoplasmic signaling pathways
    M A Schwartz
    Department of Vascular Biology, The Scripps Research Institute, La Jolla, CA 92037, USA
    J Cell Sci 114:2553-60. 2001
    ..Regulation of cyclin D1 by the ERK pathway may provide a paradigm for understanding how cell adhesion can determine cell cycle progression...
  3. ncbi request reprint Networks and crosstalk: integrin signalling spreads
    Martin A Schwartz
    Division of Vascular Biology, Department of Cell Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, USA
    Nat Cell Biol 4:E65-8. 2002
    ..We discuss how adhesive signalling is coordinately regulated through intersecting networks. We also examine some examples of how some forms of integrin crosstalk may lead to unforeseen and potentially deleterious responses...
  4. ncbi request reprint Signaling networks linking integrins and rho family GTPases
    M A Schwartz
    Dept of Vascular Biology, The Scripps Research Institute, La Jolla, CA 92037, USA
    Trends Biochem Sci 25:388-91. 2000
    ..Recently, it has also become apparent that integrins regulate Rho GTPases and vice versa. Integrins and GTPases might therefore be organized into complex signaling cascades that regulate cell behavior...
  5. ncbi request reprint Interactions between mitogenic stimuli, or, a thousand and one connections
    M A Schwartz
    Department of Vascular Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Curr Opin Cell Biol 11:197-202. 1999
    ..These interactions enable cells to integrate information from multiple stimuli that regulate cell cycle progression...
  6. pmc Integrin-mediated mechanotransduction requires its dynamic interaction with specific extracellular matrix (ECM) ligands
    S Jalali
    Department of Bioengineering and The Whitaker Institute of Biomedical Engineering, University of California, San Diego, La Jolla, CA 92093-0427, USA
    Proc Natl Acad Sci U S A 98:1042-6. 2001
    ..Our results indicate that the dynamic formation of new connections between integrins and their specific ECM ligands is critical in relaying the signals induced by shear stress to intracellular pathways...
  7. pmc Death effector domain protein PEA-15 potentiates Ras activation of extracellular signal receptor-activated kinase by an adhesion-independent mechanism
    J W Ramos
    Department of Vascular Biology, The Scripps Research Institute, La Jolla, California 92037, USA
    Mol Biol Cell 11:2863-72. 2000
    ..In contrast, the DED of PEA-15 is essential for its capacity to activate ERK. The ability of PEA-15 to simultaneously inhibit apoptosis and potentiate Ras-to-Erk signaling may be of importance for oncogenic processes...
  8. ncbi request reprint Increased filamin binding to beta-integrin cytoplasmic domains inhibits cell migration
    D A Calderwood
    Department of Vascular Biology, The Scripps Research Institute, 10550 N Torrey Pines Rd, La Jolla, California 92037, USA
    Nat Cell Biol 3:1060-8. 2001
    ..Thus, tight filamin binding restricts integrin-dependent cell migration by inhibiting transient membrane protrusion and cell polarization...
  9. pmc Activation of integrins in endothelial cells by fluid shear stress mediates Rho-dependent cytoskeletal alignment
    E Tzima
    Department of Vascular Biology, The Scripps Research Institute, 10550 N.Torrey Pines Road, La Jolla, CA 92037, USA
    EMBO J 20:4639-47. 2001
    ..This transient inhibition is necessary for cytoskeletal alignment in the direction of flow. The results therefore define the role of integrins and Rho in a pathway leading to endothelial cell adaptation to flow...
  10. ncbi request reprint Rac recruits high-affinity integrin alphavbeta3 to lamellipodia in endothelial cell migration
    W B Kiosses
    Department of Vascular Biology, 10550 North Torrey Pines Road, La Jolla, California 92037, USA
    Nat Cell Biol 3:316-20. 2001
    ..By using WOW-1, we have identified the selective recruitment of high-affinity integrins as a mechanism by which lamellipodia promote formation of new adhesions at the leading edge in cell migration...
  11. pmc Regulation of the small GTP-binding protein Rho by cell adhesion and the cytoskeleton
    X D Ren
    Department of Vascular Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    EMBO J 18:578-85. 1999
    ..Our results show that ECM, cytoskeletal structures and soluble factors all contribute to regulation of Rho activity...
  12. pmc Insulin-like growth factor receptor cooperates with integrin alpha v beta 5 to promote tumor cell dissemination in vivo
    P C Brooks
    Department of Immunology, Scripps Research Institute, La Jolla, California 92037, USA
    J Clin Invest 99:1390-8. 1997
    ..These findings provide evidence that integrin ligation, in conjunction with cytokine activation, plays an important role in the dissemination of malignant tumor cells...
  13. ncbi request reprint c-Abl tyrosine kinase binds and phosphorylates phospholipid scramblase 1
    J Sun
    Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, California 92037, USA
    J Biol Chem 276:28984-90. 2001
    ..These findings indicate that c-Abl binds and phosphorylates PLSCR1, and raise the possibility that an interaction between c-Abl and plasma membrane PLSCR1 might contribute to the cellular response to genotoxic stress...
  14. pmc Biologically active fragment of a human tRNA synthetase inhibits fluid shear stress-activated responses of endothelial cells
    E Tzima
    Department of Molecular Biology, The Scripps Research Institute, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 100:14903-7. 2003
    ..Thus, this biological fragment of TrpRS may have a role in the maintenance of vascular homeostasis...
  15. pmc Affinity modulation of platelet integrin alphaIIbbeta3 by beta3-endonexin, a selective binding partner of the beta3 integrin cytoplasmic tail
    H Kashiwagi
    Department of Vascular Biology, The Scripps Research Institute, La Jolla, California 92037, USA
    J Cell Biol 137:1433-43. 1997
    ..By analogy, the adhesive function of platelets may be regulated by such protein-protein interactions at the level of the cytoplasmic tails of alphaIIbbeta3...
  16. ncbi request reprint Integrins regulate the association and phosphorylation of paxillin by c-Abl
    J M Lewis
    Department of Vascular Biology, The Scripps Research Institute, La Jolla, California 92037, USA
    J Biol Chem 273:14225-30. 1998
    ..In addition, paxillin was found to serve as substrate for the adhesion-activated c-Abl kinase. These results suggest that c-Abl may mediate effects of integrins on cell functions by phosphorylating paxillin...
  17. pmc Differential alphav integrin-mediated Ras-ERK signaling during two pathways of angiogenesis
    John D Hood
    Department of Immunology, The Scripps Research Institute, La Jolla, CA 92037, USA
    J Cell Biol 162:933-43. 2003
    ..Thus, integrins alphavbeta3 and alphavbeta5 differentially regulate the Ras-ERK pathway, accounting for distinct vascular responses during two pathways of angiogenesis...
  18. ncbi request reprint Integrins regulate Rac targeting by internalization of membrane domains
    Miguel A Del Pozo
    Department of Cell Biology, Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Science 303:839-42. 2004
    ..Regulation of lipid rafts by integrin signals may regulate the location of membrane domains such as lipid rafts and thereby control domain-specific signaling events in anchorage-dependent cells...
  19. pmc Rho mediates the shear-enhancement of endothelial cell migration and traction force generation
    Yan Ting Shiu
    Department of Bioengineering and The Whitaker Institute of Biomedical Engineering, University of California at San Diego, La Jolla, California 92093 0427, USA
    Biophys J 86:2558-65. 2004
    ..Our results indicate that shear stress enhances the migration speed of endothelial cells by modulating the biophysical force of tractions through the biochemical pathway of Rho-p160ROCK...
  20. ncbi request reprint VE-cadherin links tRNA synthetase cytokine to anti-angiogenic function
    Eleni Tzima
    Skaggs Institute for Chemical Biology, Department of Chemistry and Molecular Biology, The Scripps Research Institute, La Jolla, California 92037, USA
    J Biol Chem 280:2405-8. 2005
    ..Binding of T2-TrpRS inhibited VEGF-induced ERK activation and EC migration. Thus, a VE-cadherin-dependent pathway is proposed to link T2-TrpRS to inhibition of new blood vessel formation...
  21. ncbi request reprint Guanine exchange-dependent and -independent effects of Vav1 on integrin-induced T cell spreading
    Miguel Angel del Pozo
    Division of Cell Biology, La Jolla Institute for Allergy and Immunology, San Diego, CA 92121, USA
    J Immunol 170:41-7. 2003
    ..In contrast, a point mutation in the SH2 domain of Vav1 abolished this synergistic effect. Therefore, our results suggest a new regulatory effect of Vav1 in T cell spreading, which is independent of its guanine exchange factor activity...
  22. ncbi request reprint A fragment of paxillin binds the alpha 4 integrin cytoplasmic domain (tail) and selectively inhibits alpha 4-mediated cell migration
    Shouchun Liu
    Department of Vascular Biology and Cell Biology, The Scripps Research Institute, La Jolla, California 92037, USA
    J Biol Chem 277:20887-94. 2002
    ..Thus, paxillin binding to the alpha(4) tail leads to enhanced cell migration and inhibition of the alpha(4)-paxillin interaction selectively blocks the alpha4-dependent cellular responses...
  23. ncbi request reprint Suppression of integrin activation: a novel function of a Ras/Raf-initiated MAP kinase pathway
    P E Hughes
    Department of Vascular Biology, The Scripps Research Institute, La Jolla, California 92037, USA
    Cell 88:521-30. 1997
    ..Thus, regulation of integrin affinity state is a novel, transcription-independent function of a Ras-linked MAP kinase pathway that may mediate a negative feedback loop in integrin function...
  24. ncbi request reprint Localized Rac activation dynamics visualized in living cells
    V S Kraynov
    Department of Cell Biology, The Scripps Research Institute, La Jolla, CA 92037, USA
    Science 290:333-7. 2000
    ..FLAIR exemplifies a generally applicable approach for examining spatio-temporal control of protein activity...
  25. ncbi request reprint Zizimin1, a novel Cdc42 activator, reveals a new GEF domain for Rho proteins
    Nahum Meller
    Division of Vascular Biology, Department of Cell Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla CA 92037, USA
    Nat Cell Biol 4:639-47. 2002
    ..CZH2-containing proteins constitute a new superfamily that includes the so-called 'CDM' proteins that bind to and activate Rac. Together, the results suggest that CZH2 is a new GEF domain for the Rho family of proteins...
  26. pmc Integrin-dependent actomyosin contraction regulates epithelial cell scattering
    Johan de Rooij
    Department of Cell Biology, The Scripps Research Institute, La Jolla, CA 92037, USA
    J Cell Biol 171:153-64. 2005
    ..We conclude that integrin-dependent actomyosin traction force mediates the disruption of cell-cell adhesion during epithelial cell scattering...
  27. ncbi request reprint Regulation of inositol lipid kinases by Rho and Rac
    X D Ren
    Department of Vascular Biology, Scripps Research Institute, La Jolla, California 92037, USA
    Curr Opin Genet Dev 8:63-7. 1998
    ..Rho family GTPases also interact with phosphatidylinositol 3-kinase, though this kinase can be either upstream or downstream of the GTPases depending upon the system...
  28. ncbi request reprint Matrix and meaning
    Martin A Schwartz
    Scripps Research Institute, Department of Vascular Biology, La Jolla, California 92037, USA
    Methods Cell Biol 69:13-6. 2002
  29. pmc Cell adhesion receptors in mechanotransduction
    Martin A Schwartz
    Department of Microbiology and Biomedical Engineering, Cardiovascular Research Center and Mellon Urological Cancer Research Institute, University of Virginia Charlottesville, VA 22908, USA
    Curr Opin Cell Biol 20:551-6. 2008
    ..Studies of developing organisms suggest that these mechanisms contribute to tissue level responses to tension and compression, thereby linking morphogenetic movements to cell fate decisions...
  30. pmc In vivo dynamics of Rac-membrane interactions
    Konstadinos Moissoglu
    Cardiovascular Research Center, University of Virginia, Charlottesville, VA 22908, USA
    Mol Biol Cell 17:2770-9. 2006
    ..These results indicate that RhoGDI controls Rac function mainly through effects on activation and/or membrane association...
  31. ncbi request reprint Integrating adhesion, protrusion, and contraction during cell migration
    Martin A Schwartz
    Department of Microbiology, University of Virginia School of Medicine, Charlottesville, VA 22908, USA
    Cell 125:1223-5. 2006
    ..In this issue of Cell, reveal how adhesion and cytoskeletal dynamics are integrated to optimize migration speed...
  32. pmc Matrix-specific suppression of integrin activation in shear stress signaling
    A Wayne Orr
    Department of Microbiology, University of Virginia, Charlottesville, VA 22908, USA
    Mol Biol Cell 17:4686-97. 2006
    ..Thus, integrins actively cross-inhibit through specific kinase pathways. These mechanisms may determine cellular responses to complex extracellular matrices...
  33. pmc Integrin-mediated adhesion regulates membrane order
    Katharina Gaus
    Centre for Vascular Research, School of Medical Sciences, University of New South Wales, Sydney, 2052 NSW, Australia
    J Cell Biol 174:725-34. 2006
    ..These results show that lipid raft properties are conferred by assembly of specific protein complexes. The ordered state within focal adhesions may have important consequences for signaling at these sites...
  34. ncbi request reprint Rac, membrane heterogeneity, caveolin and regulation of growth by integrins
    Miguel A Del Pozo
    Integrin Signalling Laboratory, Centro Nacional de Investigaciones Cardiovasculares, Melchor Fernandez Almagro 3, Madrid, Spain
    Trends Cell Biol 17:246-50. 2007
    ..This mechanism can account for the control of multiple pathways by integrins, thus providing an important mechanism for anchorage dependence of growth...
  35. pmc A fluorescence resonance energy transfer activation sensor for Arf6
    Brian Hall
    Robert M Berne Cardiovascular Research Center, University of Virginia, Charlottesville, VA 22908, USA
    Anal Biochem 374:243-9. 2008
    ..The addition of platelet-derived growth factor (PDGF) to fibroblasts triggered a rapid and transient increase in FRET, indicative of Arf6 activation. These reagents should be useful for investigations of Arf6 activation and function...
  36. pmc Blocking p21-activated kinase reduces lipopolysaccharide-induced acute lung injury by preventing polymorphonuclear leukocyte infiltration
    Jörg Reutershan
    Robert M Berne Cardiovascular Research Center, University of Virginia, Charlottesville, VA 22908 1394, USA
    Am J Respir Crit Care Med 175:1027-35. 2007
    ..p21-Activated kinase (PAK) is an effector of small GTPases and has been implicated in cell migration...
  37. pmc Function of the N-terminus of zizimin1: autoinhibition and membrane targeting
    Nahum Meller
    Cardiovascular Research Center, University of Virginia, Charlottesville, VA 22908, USA
    Biochem J 409:525-33. 2008
    ..The N-terminal PH (pleckstrin homology) domain binds phosphoinositides and mediates zizimin1 membrane targeting. These results define two novel functions for the N-terminal region of zizimin1...
  38. ncbi request reprint 12/15-lipoxygenase regulates intercellular adhesion molecule-1 expression and monocyte adhesion to endothelium through activation of RhoA and nuclear factor-kappaB
    David T Bolick
    Cardiovascular Research Center, University of Virginia, Charlottesville, VA 22908, USA
    Arterioscler Thromb Vasc Biol 25:2301-7. 2005
    ..We have previously shown a 3.5-fold increase in endothelial intercellular adhesion molecule (ICAM)-1 expression in mice overexpressing the 12/15-LO gene. We examined whether 12/15-LO activity regulated endothelial ICAM-1 expression...
  39. ncbi request reprint Rho-ROCK-LIMK-cofilin pathway regulates shear stress activation of sterol regulatory element binding proteins
    Tong Lin
    Division of Biomedical Sciences, University of California, Riverside, Riverside, Calif 92521 0121, USA
    Circ Res 92:1296-304. 2003
    ..By enhancing the SREBP-mediated cholesterol metabolism, this unique mechanism may contribute to endothelial cell functions under flow...
  40. ncbi request reprint Cell migration: integrating signals from front to back
    Anne J Ridley
    Ludwig Institute for Cancer Research, Royal Free and University College School of Medicine, London W1W 7BS, UK
    Science 302:1704-9. 2003
    ....
  41. ncbi request reprint Zizimin2: a novel, DOCK180-related Cdc42 guanine nucleotide exchange factor expressed predominantly in lymphocytes
    Akihiko Nishikimi
    Laboratory of Experimental Animal Model Research, National Institute for Longevity Sciences, National Center for Geriatrics and Gerontology, 36 3, Gengo, Morioka cho, Obu City, Aichi 474 8522, Japan
    FEBS Lett 579:1039-46. 2005
    ..Their tissue distributions are distinct, however, with zizimin2 expressed predominantly in lymphocytes and an opposite pattern for zizimin1. Zizimin3 was also analyzed and showed distinct GTPase specificity and tissue distribution...
  42. pmc Phospho-caveolin-1 mediates integrin-regulated membrane domain internalization
    Miguel A Del Pozo
    Centro Nacional de Investigaciones Cardiovasculares CNIC, Madrid 28029, Spain
    Nat Cell Biol 7:901-8. 2005
    ..These data define a novel molecular mechanism for growth and tumour suppression by caveolin-1...
  43. ncbi request reprint Rho proteins in cell migration and metastasis
    Brian Titus
    Department of Molecular Physiology and Biological Physics, University of Virginia, Charlottesville, USA
    Crit Rev Eukaryot Gene Expr 15:103-14. 2005
    ..The aim of this review is to examine the fundamental role of migration in cancer progression and to discuss the role of the Rho family of small G proteins and their effectors in this process...
  44. pmc Inhibition of enzyme activity of and cell-mediated substrate cleavage by membrane type 1 matrix metalloproteinase by newly developed mercaptosulphide inhibitors
    Douglas R Hurst
    Department of Chemistry and Biochemistry and Institute of Molecular Biophysics, Florida State University, Tallahassee, FL 32306 4390, USA
    Biochem J 392:527-36. 2005
    ..These results provide a model for mercaptosulphide inhibitor binding to MT1-MMP that may aid in the design of more potent and selective inhibitors for MT1-MMP...
  45. pmc Catalytic- and ecto-domains of membrane type 1-matrix metalloproteinase have similar inhibition profiles but distinct endopeptidase activities
    Douglas R Hurst
    Department of Chemistry and Biochemistry and Institute of Molecular Biophysics, 203 Dittmer Laboratory of Chemistry Building, Florida State University, Tallahassee, FL 32306, U S A
    Biochem J 377:775-9. 2004
    ..Ratios of K (i) values for the inhibitor pairs were found to correlate between the enzyme forms with a slope of 1.03, suggesting that the haemopexin domain does not significantly modify the enzyme active-site structure...
  46. ncbi request reprint The intermediate S1' pocket of the endometase/matrilysin-2 active site revealed by enzyme inhibition kinetic studies, protein sequence analyses, and homology modeling
    Hyun I Park
    Department of Chemistry and Biochemistry and Institute of Molecular Biophysics, Florida State University, Tallahassee, Florida 32306 4390, USA
    J Biol Chem 278:51646-53. 2003
    ....
  47. ncbi request reprint Enzymatic properties of rat myelencephalon-specific protease
    Sachiko I Blaber
    Institute of Molecular Biophysics, Florida State University, Tallahassee, Florida 32306 4380, USA
    Biochemistry 41:1165-73. 2002
    ....