Research Topics
Genomes and GenesSpecies | G A SchwartingSummaryAffiliation: The Shriver Center Country: USA Publications
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Detail Information
Publications
Semaphorin 3A is required for guidance of olfactory axons in miceG A Schwarting
The Shriver Center, Waltham, Massachusetts 02452, USA
J Neurosci 20:7691-7. 2000..These observations indicate that Sema3A expression by ensheathing cells plays an important role in guiding olfactory axons into specific compartments of the OB...- Expression of gamma-aminobutyric acid and gonadotropin-releasing hormone during neuronal migration through the olfactory systemS A Tobet
The Shriver Center, Harvard Medical School, Program in Neuroscience, Waltham, Massachusetts 02254, USA
Endocrinology 137:5415-20. 1996.... - Effects of gamma-aminobutyric acid(A) receptor manipulation on migrating gonadotropin-releasing hormone neurons through the entire migratory route in vivo and in vitroE P Bless
Eunice Kennedy Shriver Center, Division of Biomedical Sciences, Waltham, Massachusetts 02452, USA
Endocrinology 141:1254-62. 2000..These results suggest that GABA's influence on GnRH development changes as the cells move out of the nasal compartment and extend processes toward the median eminence... - Deleted in colorectal cancer (DCC) regulates the migration of luteinizing hormone-releasing hormone neurons to the basal forebrainG A Schwarting
The Shriver Center, Waltham, Massachusetts 02452, USA
J Neurosci 21:911-9. 2001..Loss of DCC function results in the migration of many LHRH neurons to inappropriate destinations... - Developmental aspect of the gonadotropin-releasing hormone systemS A Tobet
Program in Neuroscience, The Shriver Center, School of Medicine, The University of Massachusetts, 200 Trapelo Road, Waltham, MA 02452, USA
Mol Cell Endocrinol 185:173-84. 2001..By combining molecular inquiries with genetic models, single cell analyses, and an in vitro migration model, we are beginning to decipher one of the most critical events in the establishment of the reproductive axis... - Lactosamine differentially affects olfactory sensory neuron projections to the olfactory bulbGerald A Schwarting
Shriver Center, Waltham, Massachusetts 02452, USA
Dev Neurobiol 67:1627-40. 2007..Neurons that are normally lactosamine negative, survive early postnatal degeneration in beta3GnT1-/- mice but extend axons that converge on inappropriate targets in the mutant OB... - Lactosamine modulates the rate of migration of GnRH neurons during mouse developmentElizabeth Bless
Curis Inc, Cambridge, MA 02138, USA
Eur J Neurosci 24:654-60. 2006..These results suggest that the loss of lactosamine on a subset of GnRH neurons impeded the rate of migration from the nose to the brain... - Semaphorin 3A-mediated axon guidance regulates convergence and targeting of P2 odorant receptor axonsGerald A Schwarting
The Shriver Center, 200 Trapelo Road, Waltham, MA 02452, USA
Eur J Neurosci 19:1800-10. 2004..Furthermore, Sema3A plays a key role in the convergence of axons expressing the odorant receptor P2 onto their appropriate targets... - Beta1,3-N-acetylglucosaminyltransferase 1 glycosylation is required for axon pathfinding by olfactory sensory neuronsTimothy R Henion
Shriver Center, Waltham, Massachusetts 02452, USA
J Neurosci 25:1894-903. 2005..These results reveal an essential role for lactosamine in sensory axon pathfinding and in the formation of OB synaptic connections... - Minireview: recent progress in gonadotropin-releasing hormone neuronal migrationStuart A Tobet
Colorado State University, Department of Biomedical Sciences, 1617 Campus Delivery, Fort Collins, Colorado 80523, USA
Endocrinology 147:1159-65. 2006..It is likely that the multiple external factors converge on selective signal transduction pathways to engage the mechanical mechanisms needed to modulate GnRH neuronal movement and ultimately migration... - Stromal cell-derived factor-1 (chemokine C-X-C motif ligand 12) and chemokine C-X-C motif receptor 4 are required for migration of gonadotropin-releasing hormone neurons to the forebrainGerald A Schwarting
Shriver Center University of Massachusetts Medical Center, Waltham, Massachusetts 02452, USA
J Neurosci 26:6834-40. 2006..The MM is smaller in CXCR4-/- mice, suggesting that some MM cells also require SDF-1/CXCR4 function for migration and survival... - Netrin 1-mediated chemoattraction regulates the migratory pathway of LHRH neuronsGerald A Schwarting
The Shriver Center, 200 Trapelo Road, Waltham, MA 02452, USA
Eur J Neurosci 19:11-20. 2004..Loss of function through a genetic deletion in either Dcc or Ntn1 results in the migration of many LHRH neurons to inappropriate destinations... - Olfactory axon guidance: the modified rulesGerald A Schwarting
Shriver Center and Department of Cell Biology, University of Massachusetts Medical School, Worcester, Massachusetts, USA
J Neurosci Res 86:11-7. 2008..This review focuses attention on these non-OR factors and their roles in olfactory axon guidance... - Overexpression of glutamic acid decarboxylase-67 (GAD-67) in gonadotropin-releasing hormone neurons disrupts migratory fate and female reproductive function in miceSabine Heger
Division of Neuroscience, Oregon National Regional Primate Research Center, Oregon Health and Science University, Beaverton, Oregon 97006, USA
Endocrinology 144:2566-79. 2003..The possibility arises that similar abnormalities in GABA homeostasis may contribute to syndromes of hypothalamic amenorrhea/oligomenorrhea in humans... - Notch1 expression and ligand interactions in progenitor cells of the mouse olfactory epitheliumGerald A Schwarting
Shriver Center UMMS, 200 Trapelo Road, Waltham, MA 02452, USA
J Mol Histol 38:543-53. 2007..Taken together, these results further support a role for Notch signaling in the regulation of olfactory neurogenesis and cell diversity...