Peter Schultz

Summary

Affiliation: The Scripps Research Institute
Country: USA

Publications

  1. ncbi request reprint Generation of a bacterium with a 21 amino acid genetic code
    Ryan A Mehl
    Department of Chemistry, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    J Am Chem Soc 125:935-9. 2003
  2. ncbi request reprint A genetically encoded infrared probe
    Kathryn C Schultz
    Department of Chemistry and The Skaggs Institute for Chemical Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    J Am Chem Soc 128:13984-5. 2006
  3. pmc Genetic incorporation of unnatural amino acids into proteins in Mycobacterium tuberculosis
    Feng Wang
    Department of Chemistry and The Skaggs Institute for Chemical Biology, The Scripps Research Institute, La Jolla, California, United States of America
    PLoS ONE 5:e9354. 2010
  4. pmc A chemical genomic analysis of decoquinate, a Plasmodium falciparum cytochrome b inhibitor
    Tae Gyu Nam
    Department of Chemistry, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, United States
    ACS Chem Biol 6:1214-22. 2011
  5. ncbi request reprint The chemistry of the antibody molecule
    Peter G Schultz
    Department of Chemistry, The Skaggs Institute for Chemical Biology, The Scripps Research Institute, La Jolla, CA 92037, USA
    Angew Chem Int Ed Engl 41:4427-37. 2002
  6. ncbi request reprint A new strategy for the site-specific modification of proteins in vivo
    Zhiwen Zhang
    Department of Chemistry and Skaggs Institute for Chemical Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, USA
    Biochemistry 42:6735-46. 2003
  7. pmc Searching for interferon-induced genes that inhibit hepatitis B virus replication in transgenic mouse hepatocytes
    Stefan F Wieland
    Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, California 92037, USA
    J Virol 77:1227-36. 2003
  8. pmc Structural evidence for substrate strain in antibody catalysis
    Jun Yin
    Department of Chemistry, University of California, Berkeley, CA 94720, USA
    Proc Natl Acad Sci U S A 100:856-61. 2003
  9. ncbi request reprint A rugged energy landscape mechanism for trapping of transmembrane receptors during endocytosis
    Stuart S Licht
    Department of Chemistry, The Scripps Research Institute, La Jolla, California 92037, USA
    Biochemistry 42:2916-25. 2003
  10. ncbi request reprint A genetically encoded fluorescent amino acid
    Jiangyun Wang
    Department of Chemistry and The Skaggs Institute for Chemical Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, USA
    J Am Chem Soc 128:8738-9. 2006

Research Grants

  1. IN VIVO INCORPORATION OF UNNATURAL AMINO ACIDS
    Peter Schultz; Fiscal Year: 2005
  2. Nucleic Acids with Novel Structures and Functions
    Peter Schultz; Fiscal Year: 2005
  3. SYNTHESIS OF CATALYTIC ANTIBODIES
    Peter Schultz; Fiscal Year: 2006
  4. IN VIVO INCORPORATION OF UNNATURAL AMINO ACIDS
    Peter Schultz; Fiscal Year: 2006
  5. IN VIVO INCORPORATION OF UNNATURAL AMINO ACIDS
    Peter Schultz; Fiscal Year: 2007
  6. SYNTHESIS OF CATALYTIC ANTIBODIES
    Peter Schultz; Fiscal Year: 2007
  7. IN VIVO INCORPORATION OF UNNATURAL AMINO ACIDS
    Peter Schultz; Fiscal Year: 2007
  8. SYNTHESIS OF CATALYTIC ANTIBODIES
    Peter Schultz; Fiscal Year: 2009
  9. IN VIVO INCORPORATION OF UNNATURAL AMINO ACIDS
    Peter Schultz; Fiscal Year: 2009
  10. IN VIVO INCORPORATION OF UNNATURAL AMINO ACIDS
    Peter G Schultz; Fiscal Year: 2010

Collaborators

Detail Information

Publications64

  1. ncbi request reprint Generation of a bacterium with a 21 amino acid genetic code
    Ryan A Mehl
    Department of Chemistry, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    J Am Chem Soc 125:935-9. 2003
    ..This and other such organisms may provide an opportunity to examine the evolutionary consequences of adding new amino acids to the genetic repertoire, as well as generate proteins with new or enhanced biological functions...
  2. ncbi request reprint A genetically encoded infrared probe
    Kathryn C Schultz
    Department of Chemistry and The Skaggs Institute for Chemical Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    J Am Chem Soc 128:13984-5. 2006
    ..This methodology provides a useful infrared reporter of protein structure, biomolecular interactions, and conformational changes...
  3. pmc Genetic incorporation of unnatural amino acids into proteins in Mycobacterium tuberculosis
    Feng Wang
    Department of Chemistry and The Skaggs Institute for Chemical Biology, The Scripps Research Institute, La Jolla, California, United States of America
    PLoS ONE 5:e9354. 2010
    ..The establishment of the unnatural amino acid expression system in Mtb, an intracellular pathogen, should facilitate studies of TB biology and vaccine development...
  4. pmc A chemical genomic analysis of decoquinate, a Plasmodium falciparum cytochrome b inhibitor
    Tae Gyu Nam
    Department of Chemistry, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, United States
    ACS Chem Biol 6:1214-22. 2011
    ..The basis for this difference was revealed by molecular docking studies, in which both of these inhibitors were shown to have distinctly different modes of binding within the ubiquinol-binding site of cytochrome b...
  5. ncbi request reprint The chemistry of the antibody molecule
    Peter G Schultz
    Department of Chemistry, The Skaggs Institute for Chemical Biology, The Scripps Research Institute, La Jolla, CA 92037, USA
    Angew Chem Int Ed Engl 41:4427-37. 2002
    ..Importantly, theses studies are providing fundamental molecular insights into many biological, chemical, and physical phenomena, as well as changing the way we approach the synthesis of new molecular function...
  6. ncbi request reprint A new strategy for the site-specific modification of proteins in vivo
    Zhiwen Zhang
    Department of Chemistry and Skaggs Institute for Chemical Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, USA
    Biochemistry 42:6735-46. 2003
    ..The genetic incorporation of a nonproteinogenic "ketone handle" into proteins provides a powerful tool for the introduction of biophysical probes for the structural and functional analysis of proteins in vitro or in vivo...
  7. pmc Searching for interferon-induced genes that inhibit hepatitis B virus replication in transgenic mouse hepatocytes
    Stefan F Wieland
    Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, California 92037, USA
    J Virol 77:1227-36. 2003
    ..We have already exploited this information by demonstrating that the antiviral activity of IFN-alpha/beta and IFN-gamma is proteasome dependent...
  8. pmc Structural evidence for substrate strain in antibody catalysis
    Jun Yin
    Department of Chemistry, University of California, Berkeley, CA 94720, USA
    Proc Natl Acad Sci U S A 100:856-61. 2003
    ..A comparison of these structures with the corresponding structures of the affinity-matured antibody 7G12 reveals the molecular mechanism by which the immune system evolves binding energy to catalyze this reaction...
  9. ncbi request reprint A rugged energy landscape mechanism for trapping of transmembrane receptors during endocytosis
    Stuart S Licht
    Department of Chemistry, The Scripps Research Institute, La Jolla, California 92037, USA
    Biochemistry 42:2916-25. 2003
    ..This mechanism, which allows efficient trapping to coexist with rapid exchange, may also be relevant to other biological processes involving binding in heterogeneous chemical environments...
  10. ncbi request reprint A genetically encoded fluorescent amino acid
    Jiangyun Wang
    Department of Chemistry and The Skaggs Institute for Chemical Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, USA
    J Am Chem Soc 128:8738-9. 2006
    ....
  11. pmc Crystal structure of a biosynthetic sulfo-hirudin complexed to thrombin
    Chang C Liu
    Department of Chemistry and The Skaggs Institute for Chemical Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, USA
    J Am Chem Soc 129:10648-9. 2007
  12. ncbi request reprint The incorporation of a photoisomerizable amino acid into proteins in E. coli
    Mohua Bose
    Department of Chemistry, The Scripps Research Institute, La Jolla, California 92037, USA
    J Am Chem Soc 128:388-9. 2006
    ..The ability to selectively incorporate AzoPhe into proteins at defined sites should make it possible to regulate a variety of biological processes with light, including enzyme, receptor, and ion channel activity...
  13. ncbi request reprint Three sweet receptor genes are clustered in human chromosome 1
    Jiayu Liao
    Department of Chemistry, Skaggs Institute for Chemical Biology, Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, USA
    Mamm Genome 14:291-301. 2003
    ..All three hT1Rs genes are expressed selectively in human taste receptor cells in the fungiform papillae, consistent with their role in taste perception...
  14. ncbi request reprint A role for chemistry in stem cell biology
    Sheng Ding
    Department of Chemistry and The Skaggs Institute for Chemical Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, USA
    Nat Biotechnol 22:833-40. 2004
    ..Such molecules will likely provide new insights into stem cell biology, and may ultimately contribute to effective medicines for tissue repair and regeneration...
  15. ncbi request reprint A small molecule with osteogenesis-inducing activity in multipotent mesenchymal progenitor cells
    Xu Wu
    Department of Chemistry and The Skaggs Institute for Chemical Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, USA
    J Am Chem Soc 124:14520-1. 2002
    ..It differentiates multipotent mesenchymal progenitor cells into an osteoblast lineage. It will serve as a unique chemical tool to study the molecular mechanisms of osteogenesis of stem cells and bone development...
  16. pmc In vivo incorporation of unnatural amino acids to probe structure, dynamics, and ligand binding in a large protein by nuclear magnetic resonance spectroscopy
    Susan E Cellitti
    Genomics Institute of the Novartis Research Foundation, 10675 John Jay Hopkins Drive, San Diego, California 92121 1125, USA
    J Am Chem Soc 130:9268-81. 2008
    ....
  17. ncbi request reprint Inhibition and reversal of myogenic differentiation by purine-based microtubule assembly inhibitors
    Omar D Perez
    Department of Chemistry, University of California, Berkeley 94720, USA
    Chem Biol 9:475-83. 2002
    ..These results suggest that myoseverin may have applications in muscle regeneration and stem cell differentiation...
  18. ncbi request reprint Structural characterization of a p-acetylphenylalanyl aminoacyl-tRNA synthetase
    James M Turner
    Department of Chemistry, The Scripps Research Institute, La Jolla, California 92037, USA
    J Am Chem Soc 127:14976-7. 2005
    ..Molecular recognition is due to altered hydrogen bonding and packing interactions with bound substrate that result from changes in both side-chain and backbone conformation...
  19. ncbi request reprint Small molecules and future regenerative medicine
    Sheng Ding
    Department of Chemistry, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Curr Top Med Chem 5:383-95. 2005
    ..Such molecules will likely provide new insights into stem cell biology, and may ultimately contribute to effective medicines for tissue repair and regeneration...
  20. ncbi request reprint Genetic introduction of a diketone-containing amino acid into proteins
    Huaqiang Zeng
    Department of Chemistry and The Skaggs Institute for Chemical Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Bioorg Med Chem Lett 16:5356-9. 2006
    ..Proteins containing this unnatural amino acid can be efficiently and selectively modified with hydroxylamine derivatives of fluorophores and other biophysical probes...
  21. ncbi request reprint An efficient system for the evolution of aminoacyl-tRNA synthetase specificity
    Stephen W Santoro
    Department of Chemistry and The Skaggs Institute for Chemical Biology, The Scripps Research Institute, SR202, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Nat Biotechnol 20:1044-8. 2002
    ..The new enzymes can be used to produce milligram-per-liter quantities of unnatural amino acid-containing protein in E. coli...
  22. pmc Genomic analysis of the host response to hepatitis C virus infection
    Andrew I Su
    Department of Chemistry, The Scripps Research Institute, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 99:15669-74. 2002
    ..Our results reveal genome-wide transcriptional changes that reflect the establishment, spread, and control of infection, and they reveal potentially unique antiviral programs associated with clearance of HCV infection...
  23. ncbi request reprint Recombinant expression of selectively sulfated proteins in Escherichia coli
    Chang C Liu
    Department of Chemistry and Skaggs Institute for Chemical Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, USA
    Nat Biotechnol 24:1436-40. 2006
    ..This general approach to the biosynthesis of sulfated proteins should facilitate further study and application of tyrosine sulfation...
  24. ncbi request reprint The genetic incorporation of a distance probe into proteins in Escherichia coli
    Meng Lin Tsao
    Department of Chemistry and The Skaggs Institute for Chemical Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, USA
    J Am Chem Soc 128:4572-3. 2006
    ..Thus, the pNO2-Phe/Trp pair should be a useful biophysical probe of protein structure and function...
  25. ncbi request reprint Identification of the tyrosine phosphatase PTP-MEG2 as an antagonist of hepatic insulin signaling
    Charles Y Cho
    Genomics Institute of the Novartis Research Foundation, 10675 John Jay Hopkins Drive, San Diego, CA 92121, USA
    Cell Metab 3:367-78. 2006
    ..These data implicate PTP-MEG2 as a mediator of blood glucose homeostasis through antagonism of insulin signaling, and suggest that modulation of PTP-MEG2 activity may be an effective strategy in the treatment of type 2 diabetes...
  26. ncbi request reprint A chemical toolkit for proteins--an expanded genetic code
    Jianming Xie
    Department of Chemistry and Skaggs Institute for Chemical Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, USA
    Nat Rev Mol Cell Biol 7:775-82. 2006
    ..This provides a powerful tool for exploring protein structure and function in vitro and in vivo, and for generating proteins with new or enhanced properties...
  27. pmc A genetically encoded fluorescent amino acid
    Daniel Summerer
    Department of Chemistry, The Scripps Research Institute, 10550 North Torrey Pines Road, SR202, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 103:9785-9. 2006
    ..The strategy described here should be applicable to a number of different fluorophores in both prokaryotic and eukaryotic organisms, and it should facilitate both biochemical and cellular studies of protein structure and function...
  28. ncbi request reprint Efficient incorporation of unnatural amino acids into proteins in Escherichia coli
    Youngha Ryu
    Department of Chemistry and The Skaggs Institute for Chemical Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, USA
    Nat Methods 3:263-5. 2006
    ..jannaschii tyrosyl-tRNA synthetase (MjTyrRS) is expressed under control of a mutant glnS (glnS') promoter...
  29. ncbi request reprint Identification and characterization of small-molecule inducers of epidermal keratinocyte differentiation
    Jiyong Hong
    ACS Chem Biol 2:171-5. 2007
    ....
  30. doi request reprint Site-specific incorporation of methyl- and acetyl-lysine analogues into recombinant proteins
    Jiantao Guo
    Department of Chemistry and The Skaggs Institute for Chemical Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Angew Chem Int Ed Engl 47:6399-401. 2008
  31. doi request reprint Gene expression signatures and small-molecule compounds link a protein kinase to Plasmodium falciparum motility
    Nobutaka Kato
    Department of Cell Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, ICND202 La Jolla, California 92037, USA
    Nat Chem Biol 4:347-56. 2008
    ..falciparum and a large reduction in intracellular parasites in Toxoplasma gondii, which suggests a possible role for PfCDPK1 in regulation of parasite motility during egress and invasion...
  32. ncbi request reprint Addition of an alpha-hydroxy acid to the genetic code of bacteria
    Jiantao Guo
    Department of Chemistry and The Skaggs Institute for Chemical Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Angew Chem Int Ed Engl 47:722-5. 2008
  33. ncbi request reprint A genetically encoded diazirine photocrosslinker in Escherichia coli
    Eric M Tippmann
    Department of Chemistry and The Skaggs Institute for Chemical Biology, The Scripps Research Institute, 10550 N Torrey Pines Rd, La Jolla, CA 92037, USA
    Chembiochem 8:2210-4. 2007
  34. ncbi request reprint Site-specific insertion of 3-aminotyrosine into subunit alpha2 of E. coli ribonucleotide reductase: direct evidence for involvement of Y730 and Y731 in radical propagation
    Mohammad R Seyedsayamdost
    Department of Chemistry, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, Massachusetts 02139 4307, USA
    J Am Chem Soc 129:15060-71. 2007
    ..The observed NH2Y. may constitute the first detection of an amino acid radical intermediate in the proposed radical propagation pathway during turnover...
  35. pmc Gene expression during the priming phase of liver regeneration after partial hepatectomy in mice
    Andrew I Su
    Department of Chemistry and Molecular and Experimental Medicine, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 99:11181-6. 2002
    ..The genome-wide changes that are observed provide a detailed and comprehensive map of the initial priming stage of liver regeneration...
  36. pmc Inhibition of histone deacetylase activity induces developmental plasticity in oligodendrocyte precursor cells
    Costas A Lyssiotis
    The Skaggs Institute of Chemical Biology and Department of Chemistry, The Scripps Research Institute, 10550 North Torry Pines Road, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 104:14982-7. 2007
    ..This series of experiments demonstrates that global histone acetylation, induced by HDAC inhibition, can partially reverse the lineage restriction of OPCs, thereby inducing developmental plasticity...
  37. ncbi request reprint A small-molecule antagonist of the hedgehog signaling pathway
    Jongkook Lee
    Dept of Chemistry and The Skaggs Institute for Chemical Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, USA
    Chembiochem 8:1916-9. 2007
  38. ncbi request reprint Structural basis for the recognition of para-benzoyl-L-phenylalanine by evolved aminoacyl-tRNA synthetases
    Wenshe Liu
    Department of Chemistry and The Skaggs Institute for Chemical Biology, The Scripps Research Institute, 10550 N Torrey Pines Rd, La Jolla, CA 92037, USA
    Angew Chem Int Ed Engl 46:6073-5. 2007
  39. ncbi request reprint An improved system for the generation and analysis of mutant proteins containing unnatural amino acids in Saccharomyces cerevisiae
    Shawn Chen
    Department of Chemistry and The Skaggs Institute for Chemical Biology, The Scripps Research Institute, La Jolla, CA 92037, USA
    J Mol Biol 371:112-22. 2007
    ..Mass spectrometric analysis of the hSOD mutants was performed with high dynamic range using multiple reaction monitoring that provided new insights into the factors that control the fidelity of unnatural amino acid incorporation...
  40. ncbi request reprint Structural plasticity and the evolution of antibody affinity and specificity
    Jun Yin
    Department of Chemistry, University of California at Berkeley, Berkeley, CA 94720, USA
    J Mol Biol 330:651-6. 2003
    ....
  41. ncbi request reprint A synthetic small molecule that induces neuronal differentiation of adult hippocampal neural progenitor cells
    Masaki Warashina
    Department of Chemistry and The Skaggs Institute for Chemical Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, SR202, La Jolla, CA 92037, USA
    Angew Chem Int Ed Engl 45:591-3. 2006
  42. pmc Synthetic small molecules that control stem cell fate
    Sheng Ding
    Department of Chemistry and The Skaggs Institute for Chemical Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 100:7632-7. 2003
    ..This and such other molecules are likely to provide insights into the molecular mechanisms that control stem cell fate, and may ultimately be useful to in vivo stem cell biology and therapy...
  43. pmc Addition of the keto functional group to the genetic code of Escherichia coli
    Lei Wang
    Department of Chemistry, University of California, Berkeley 94720, USA
    Proc Natl Acad Sci U S A 100:56-61. 2003
    ..This additional genetically encoded amino acid should greatly expand our ability to manipulate protein structure and function both in vitro and in living cells...
  44. ncbi request reprint A potent and highly selective sulfotransferase inhibitor
    Eli Chapman
    Department of Chemistry and The Skaggs Institute for Chemical Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, USA
    J Am Chem Soc 124:14524-5. 2002
    ..The most potent of these inhibitors was tested against a variety of other purine binding enzymes and showed remarkable specificity...
  45. ncbi request reprint The selective incorporation of alkenes into proteins in Escherichia coli
    Zhiwen Zhang
    Department of Chemistry, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Angew Chem Int Ed Engl 41:2840-2. 2002
  46. pmc Profiling protein function with small molecule microarrays
    Nicolas Winssinger
    Genomics Institute of the Novartis Research Foundation, 10675 John Jay Hopkins Drive, San Diego, CA 92121, USA
    Proc Natl Acad Sci U S A 99:11139-44. 2002
    ....
  47. pmc Addition of a photocrosslinking amino acid to the genetic code of Escherichiacoli
    Jason W Chin
    Department of Chemistry and The Skaggs Institute for Chemical Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 99:11020-4. 2002
    ..Irradiation resulted in efficient crosslinking (>50%) of the protein subunits. This methodology may prove useful for discovering and defining protein interactions in vitro and in vivo...
  48. ncbi request reprint Coordinated transcription of key pathways in the mouse by the circadian clock
    Satchidananda Panda
    The Genomics Institute of the Novartis Research Foundation, San Diego, California 92121, USA
    Cell 109:307-20. 2002
    ..Importantly, rate-limiting steps in these various pathways were key sites of circadian control, highlighting the fundamental role that circadian clocks play in cellular and organismal physiology...
  49. pmc Directed evolution of the site specificity of Cre recombinase
    Stephen W Santoro
    Department of Chemistry and The Skaggs Institute for Chemical Biology, The Scripps Research Institute, SR202, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 99:4185-90. 2002
    ..This and other systems should contribute to our understanding of protein-DNA recognition and may eventually be used to evolve custom-tailored recombinases that can be used for gene study and inactivation...
  50. pmc Large-scale analysis of the human and mouse transcriptomes
    Andrew I Su
    Department of Chemistry, The Scripps Research Institute, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 99:4465-70. 2002
    ..Finally, to allow the scientific community to use this resource, we have built a free and publicly accessible website (http://expression.gnf.org) that integrates data visualization and curation of current gene annotations...
  51. ncbi request reprint Adding L-3-(2-Naphthyl)alanine to the genetic code of E. coli
    Lei Wang
    Department of Chemistry, University of California at Berkeley, Berkeley, California 94720, USA
    J Am Chem Soc 124:1836-7. 2002
    ..The expansion of the genetic code to include amino acids beyond the common 20 would provide an opportunity to better understand and possibly enhance protein (and perhaps organismal) function...
  52. ncbi request reprint Directed evolution of the substrate specificities of a site-specific recombinase and an aminoacyl-tRNA synthetase using fluorescence-activated cell sorting (FACS)
    Stephen W Santoro
    Department of Chemistry and the Skaggs Instutute for Chemical Biology, The Scripps Research Institute, La Jolla, CA, USA
    Methods Mol Biol 230:291-312. 2003
  53. ncbi request reprint Progress toward an expanded eukaryotic genetic code
    Jason W Chin
    Department of Chemistry, Skaggs Institute for Chemical Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Chem Biol 10:511-9. 2003
    ..This method will facilitate the isolation of a range of aminoacyl-tRNA synthetase (aaRS)/tRNA(CUA) activities from large libraries of mutant synthetases...
  54. ncbi request reprint Adding amino acids to the genetic repertoire
    Jianming Xie
    Department of Chemistry and Skaggs Institute for Chemical Biology, The Scripps Research Institute, La Jolla, CA 92037, USA
    Curr Opin Chem Biol 9:548-54. 2005
    ....
  55. ncbi request reprint Site-specific incorporation of the mucin-type N-acetylgalactosamine-alpha-O-threonine into protein in Escherichia coli
    Ran Xu
    Department of Chemistry, and The Skaggs Institute for Chemical Biology, The Scripps Research Institute, 10550 Torrey Pines Road, La Jolla, California 92037, USA
    J Am Chem Soc 126:15654-5. 2004
    ..coli to contain the other major O-linked glycan, N-acetylgalactosamine-alpha-O-threonine (GalNAc-a-Thr)...
  56. ncbi request reprint An expanding genetic code
    T Ashton Cropp
    Department of Chemistry and Biochemistry, University of Maryland, College Park, MD 20742, USA
    Trends Genet 20:625-30. 2004
    ..Moreover, by lifting the constraints of the existing 20-amino-acid code, it should be possible to generate proteins and perhaps entire organisms with new or enhanced properties...
  57. ncbi request reprint Substrate recognition by the AAA+ chaperone ClpB
    Christian Schlieker
    Zentrum fur Molekulare Biologie, Universitat Heidelberg, Im Neuenheimer Feld 282, Heidelberg 69120, Germany
    Nat Struct Mol Biol 11:607-15. 2004
    ..The location of the identified binding site also suggests a possible translocation mechanism as an integral part of the ClpB-dependent disaggregation reaction...
  58. pmc Identification of p53 regulators by genome-wide functional analysis
    Qihong Huang
    Department of Chemistry, The Scripps Research Institute, Mail Stop SR202, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 101:3456-61. 2004
    ..These results suggest that these transcription factors are members of an evolutionarily conserved network that governs p53 function...
  59. ncbi request reprint A new strategy for the synthesis of glycoproteins
    Zhiwen Zhang
    Department of Chemistry, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Science 303:371-3. 2004
    ..This approach should be generally applicable to other posttranslational modifications such as protein phosphorylation, acetylation, and methylation...
  60. ncbi request reprint Dedifferentiation of lineage-committed cells by a small molecule
    Shuibing Chen
    Department of Chemistry and The Skaggs Institute for Chemical Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, USA
    J Am Chem Soc 126:410-1. 2004
    ..This and other such molecules are likely to provide new insights into the molecular mechanisms that control cellular dedifferentiation and may ultimately be useful to in vivo stem cell biology and therapy...
  61. ncbi request reprint Site-specific incorporation of a redox-active amino acid into proteins
    Lital Alfonta
    Department of Chemistry and The Skaggs Institute for Chemical Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    J Am Chem Soc 125:14662-3. 2003
    ..The ability to incorporate a redox-active amino acid site specifically into proteins should facilitate the study of electron transfer in proteins, as well as enable the engineering of redox proteins with novel properties...
  62. ncbi request reprint Adding amino acids with novel reactivity to the genetic code of Saccharomyces cerevisiae
    Alexander Deiters
    Department of Chemistry, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, USA
    J Am Chem Soc 125:11782-3. 2003
    ..As an example, we have shown that proteins containing these amino acids can be efficiently bioconjugated with small organic molecules by a [3 + 2] cycloaddition reaction that is mild enough for the manipulation of biological samples...
  63. ncbi request reprint An expanded eukaryotic genetic code
    Jason W Chin
    Department of Chemistry and Skaggs Institute for Chemical Biology, Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Science 301:964-7. 2003
    ....
  64. ncbi request reprint A combinatorial scaffold approach toward kinase-directed heterocycle libraries
    Sheng Ding
    Department of Chemistry and The Skaggs Institute for Chemical Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, USA
    J Am Chem Soc 124:1594-6. 2002
    ..Libraries consisting of discrete and highly diverse heterocyclic small molecules constructed with these chemistries are currently being evaluated in a variety of cell and protein-based assays...

Research Grants29

  1. IN VIVO INCORPORATION OF UNNATURAL AMINO ACIDS
    Peter Schultz; Fiscal Year: 2005
    ..These studies should dramatically expand our ability to manipulate protein structure in order to create proteins with new functions and to probe protein structure and function in vitro and in vivo. ..
  2. Nucleic Acids with Novel Structures and Functions
    Peter Schultz; Fiscal Year: 2005
    ..In addition to the applications described above, these experiments will likely provide new insights into nucleic acid structure, function and recognition. ..
  3. SYNTHESIS OF CATALYTIC ANTIBODIES
    Peter Schultz; Fiscal Year: 2006
    ..abstract_text> ..
  4. IN VIVO INCORPORATION OF UNNATURAL AMINO ACIDS
    Peter Schultz; Fiscal Year: 2006
    ..These studies should dramatically expand our ability to manipulate protein structure in order to create proteins with new functions and to probe protein structure and function in vitro and in vivo. ..
  5. IN VIVO INCORPORATION OF UNNATURAL AMINO ACIDS
    Peter Schultz; Fiscal Year: 2007
    ..These studies should dramatically expand our ability to manipulate protein structure in order to create proteins with new functions and to probe protein structure and function in vitro and in vivo. ..
  6. SYNTHESIS OF CATALYTIC ANTIBODIES
    Peter Schultz; Fiscal Year: 2007
    ..These latter projects will provide new insights into the evolution of protein structure and function, and the role of redox processes in biological recognition and cell signaling, respectively. ..
  7. IN VIVO INCORPORATION OF UNNATURAL AMINO ACIDS
    Peter Schultz; Fiscal Year: 2007
    ..These studies should dramatically expand our ability to manipulate protein structure in order to create proteins with new functions and to probe protein structure and function in vitro and in vivo. ..
  8. SYNTHESIS OF CATALYTIC ANTIBODIES
    Peter Schultz; Fiscal Year: 2009
    ..These latter projects will provide new insights into the evolution of protein structure and function, and the role of redox processes in biological recognition and cell signaling, respectively. ..
  9. IN VIVO INCORPORATION OF UNNATURAL AMINO ACIDS
    Peter Schultz; Fiscal Year: 2009
    ..The result will be new tools to study protein function in vitro and in vivo. It should also be possible to create homogenous "chemically mutated" therapeutic proteins and vaccines with enhanced activities and improved pharmacology. ..
  10. IN VIVO INCORPORATION OF UNNATURAL AMINO ACIDS
    Peter G Schultz; Fiscal Year: 2010
    ..The result will be new tools to study protein function in vitro and in vivo. It should also be possible to create homogenous "chemically mutated" therapeutic proteins and vaccines with enhanced activities and improved pharmacology. ..
  11. Nucleic Acids with Novel Structures and Functions
    Peter Schultz; Fiscal Year: 2004
    ..In addition to the applications described above, these experiments will likely provide new insights into nucleic acid structure, function and recognition. ..
  12. Single Molecule Studies of Biomolecules
    Peter Schultz; Fiscal Year: 2004
    ..abstract_text> ..
  13. IN VIVO INCORPORATION OF UNNATURAL AMINO ACIDS
    Peter Schultz; Fiscal Year: 2001
    ..abstract_text> ..
  14. Single Molecule Studies of Biomolecules
    Peter Schultz; Fiscal Year: 2001
    ..abstract_text> ..
  15. IN VIVO INCORPORATION OF UNNATURAL AMINO ACIDS
    Peter Schultz; Fiscal Year: 2002
    ..abstract_text> ..
  16. Single Molecule Studies of Biomolecules
    Peter Schultz; Fiscal Year: 2002
    ..abstract_text> ..
  17. Nucleic Acids with Novel Structures and Functions
    Peter Schultz; Fiscal Year: 2002
    ..In addition to the applications described above, these experiments will likely provide new insights into nucleic acid structure, function and recognition. ..
  18. SYNTHESIS OF CATALYTIC ANTIBODIES
    Peter Schultz; Fiscal Year: 2003
    ..abstract_text> ..
  19. IN VIVO INCORPORATION OF UNNATURAL AMINO ACIDS
    Peter Schultz; Fiscal Year: 2003
    ..abstract_text> ..
  20. Single Molecule Studies of Biomolecules
    Peter Schultz; Fiscal Year: 2003
    ..abstract_text> ..
  21. Nucleic Acids with Novel Structures and Functions
    Peter Schultz; Fiscal Year: 2003
    ..In addition to the applications described above, these experiments will likely provide new insights into nucleic acid structure, function and recognition. ..
  22. SYNTHESIS OF CATALYTIC ANTIBODIES
    Peter G Schultz; Fiscal Year: 2010
    ..These latter projects will provide new insights into the evolution of protein structure and function, and the role of redox processes in biological recognition and cell signaling, respectively. ..