Research Topics
| Peter SchultzSummaryAffiliation: The Scripps Research Institute Country: USA Publications
Research Grants
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Detail Information
Publications
Generation of a bacterium with a 21 amino acid genetic codeRyan A Mehl
Department of Chemistry, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
J Am Chem Soc 125:935-9. 2003..This and other such organisms may provide an opportunity to examine the evolutionary consequences of adding new amino acids to the genetic repertoire, as well as generate proteins with new or enhanced biological functions...- A genetically encoded infrared probeKathryn C Schultz
Department of Chemistry and The Skaggs Institute for Chemical Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
J Am Chem Soc 128:13984-5. 2006..This methodology provides a useful infrared reporter of protein structure, biomolecular interactions, and conformational changes... - The chemistry of the antibody moleculePeter G Schultz
Department of Chemistry, The Skaggs Institute for Chemical Biology, The Scripps Research Institute, La Jolla, CA 92037, USA
Angew Chem Int Ed Engl 41:4427-37. 2002..Importantly, theses studies are providing fundamental molecular insights into many biological, chemical, and physical phenomena, as well as changing the way we approach the synthesis of new molecular function... 
Structural evidence for substrate strain in antibody catalysisJun Yin
Department of Chemistry, University of California, Berkeley, CA 94720, USA
Proc Natl Acad Sci U S A 100:856-61. 2003..A comparison of these structures with the corresponding structures of the affinity-matured antibody 7G12 reveals the molecular mechanism by which the immune system evolves binding energy to catalyze this reaction...- A rugged energy landscape mechanism for trapping of transmembrane receptors during endocytosisStuart S Licht
Department of Chemistry, The Scripps Research Institute, La Jolla, California 92037, USA
Biochemistry 42:2916-25. 2003..This mechanism, which allows efficient trapping to coexist with rapid exchange, may also be relevant to other biological processes involving binding in heterogeneous chemical environments... - A new strategy for the site-specific modification of proteins in vivoZhiwen Zhang
Department of Chemistry and Skaggs Institute for Chemical Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, USA
Biochemistry 42:6735-46. 2003..The genetic incorporation of a nonproteinogenic "ketone handle" into proteins provides a powerful tool for the introduction of biophysical probes for the structural and functional analysis of proteins in vitro or in vivo... - Recombinant expression of selectively sulfated proteins in Escherichia coliChang C Liu
Department of Chemistry and Skaggs Institute for Chemical Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, USA
Nat Biotechnol 24:1436-40. 2006..This general approach to the biosynthesis of sulfated proteins should facilitate further study and application of tyrosine sulfation... - Structural characterization of a p-acetylphenylalanyl aminoacyl-tRNA synthetaseJames M Turner
Department of Chemistry, The Scripps Research Institute, La Jolla, California 92037, USA
J Am Chem Soc 127:14976-7. 2005..Molecular recognition is due to altered hydrogen bonding and packing interactions with bound substrate that result from changes in both side-chain and backbone conformation... - Genetic introduction of a diketone-containing amino acid into proteinsHuaqiang Zeng
Department of Chemistry and The Skaggs Institute for Chemical Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
Bioorg Med Chem Lett 16:5356-9. 2006..Proteins containing this unnatural amino acid can be efficiently and selectively modified with hydroxylamine derivatives of fluorophores and other biophysical probes... - Three sweet receptor genes are clustered in human chromosome 1Jiayu Liao
Department of Chemistry, Skaggs Institute for Chemical Biology, Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, USA
Mamm Genome 14:291-301. 2003..All three hT1Rs genes are expressed selectively in human taste receptor cells in the fungiform papillae, consistent with their role in taste perception... - A genetically encoded fluorescent amino acidJiangyun Wang
Department of Chemistry and The Skaggs Institute for Chemical Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, USA
J Am Chem Soc 128:8738-9. 2006.... - The incorporation of a photoisomerizable amino acid into proteins in E. coliMohua Bose
Department of Chemistry, The Scripps Research Institute, La Jolla, California 92037, USA
J Am Chem Soc 128:388-9. 2006..The ability to selectively incorporate AzoPhe into proteins at defined sites should make it possible to regulate a variety of biological processes with light, including enzyme, receptor, and ion channel activity... - A role for chemistry in stem cell biologySheng Ding
Department of Chemistry and The Skaggs Institute for Chemical Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, USA
Nat Biotechnol 22:833-40. 2004..Such molecules will likely provide new insights into stem cell biology, and may ultimately contribute to effective medicines for tissue repair and regeneration... - Small molecules and future regenerative medicineSheng Ding
Department of Chemistry, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
Curr Top Med Chem 5:383-95. 2005..Such molecules will likely provide new insights into stem cell biology, and may ultimately contribute to effective medicines for tissue repair and regeneration... - Searching for interferon-induced genes that inhibit hepatitis B virus replication in transgenic mouse hepatocytesStefan F Wieland
Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, California 92037, USA
J Virol 77:1227-36. 2003..We have already exploited this information by demonstrating that the antiviral activity of IFN-alpha/beta and IFN-gamma is proteasome dependent... - In vivo incorporation of unnatural amino acids to probe structure, dynamics, and ligand binding in a large protein by nuclear magnetic resonance spectroscopySusan E Cellitti
Genomics Institute of the Novartis Research Foundation, 10675 John Jay Hopkins Drive, San Diego, California 92121 1125, USA
J Am Chem Soc 130:9268-81. 2008.... - A small molecule with osteogenesis-inducing activity in multipotent mesenchymal progenitor cellsXu Wu
Department of Chemistry and The Skaggs Institute for Chemical Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, USA
J Am Chem Soc 124:14520-1. 2002..It differentiates multipotent mesenchymal progenitor cells into an osteoblast lineage. It will serve as a unique chemical tool to study the molecular mechanisms of osteogenesis of stem cells and bone development... - Genomic analysis of the host response to hepatitis C virus infectionAndrew I Su
Department of Chemistry, The Scripps Research Institute, La Jolla, CA 92037, USA
Proc Natl Acad Sci U S A 99:15669-74. 2002..Our results reveal genome-wide transcriptional changes that reflect the establishment, spread, and control of infection, and they reveal potentially unique antiviral programs associated with clearance of HCV infection... - An efficient system for the evolution of aminoacyl-tRNA synthetase specificityStephen W Santoro
Department of Chemistry and The Skaggs Institute for Chemical Biology, The Scripps Research Institute, SR202, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
Nat Biotechnol 20:1044-8. 2002..The new enzymes can be used to produce milligram-per-liter quantities of unnatural amino acid-containing protein in E. coli... - Crystal structure of a biosynthetic sulfo-hirudin complexed to thrombinChang C Liu
Department of Chemistry and The Skaggs Institute for Chemical Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, USA
J Am Chem Soc 129:10648-9. 2007 - Inhibition and reversal of myogenic differentiation by purine-based microtubule assembly inhibitorsOmar D Perez
Department of Chemistry, University of California, Berkeley 94720, USA
Chem Biol 9:475-83. 2002..These results suggest that myoseverin may have applications in muscle regeneration and stem cell differentiation... - Structural basis for the recognition of para-benzoyl-L-phenylalanine by evolved aminoacyl-tRNA synthetasesWenshe Liu
Department of Chemistry and The Skaggs Institute for Chemical Biology, The Scripps Research Institute, 10550 N. Torrey Pines Rd, La Jolla, CA 92037, USA
Angew Chem Int Ed Engl 46:6073-5. 2007 - The genetic incorporation of a distance probe into proteins in Escherichia coliMeng-Lin Tsao
Department of Chemistry and The Skaggs Institute for Chemical Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, USA
J Am Chem Soc 128:4572-3. 2006..Thus, the pNO2-Phe/Trp pair should be a useful biophysical probe of protein structure and function... - Efficient incorporation of unnatural amino acids into proteins in Escherichia coliYoungha Ryu
Department of Chemistry and The Skaggs Institute for Chemical Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, USA
Nat Methods 3:263-5. 2006..jannaschii tyrosyl-tRNA synthetase (MjTyrRS) is expressed under control of a mutant glnS (glnS') promoter... - Addition of an alpha-hydroxy acid to the genetic code of bacteriaJiantao Guo
Department of Chemistry and The Skaggs Institute for Chemical Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
Angew Chem Int Ed Engl 47:722-5. 2008 
Gene expression signatures and small-molecule compounds link a protein kinase to Plasmodium falciparum motilityNobutaka Kato
Department of Cell Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, ICND202 La Jolla, California 92037, USA
Nat Chem Biol 4:347-56. 2008..falciparum and a large reduction in intracellular parasites in Toxoplasma gondii, which suggests a possible role for PfCDPK1 in regulation of parasite motility during egress and invasion...- A synthetic small molecule that induces neuronal differentiation of adult hippocampal neural progenitor cellsMasaki Warashina
Department of Chemistry and The Skaggs Institute for Chemical Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, SR202, La Jolla, CA 92037, USA
Angew Chem Int Ed Engl 45:591-3. 2006 - Adding amino acids to the genetic repertoireJianming Xie
Department of Chemistry and Skaggs Institute for Chemical Biology, The Scripps Research Institute, La Jolla, CA 92037, USA
Curr Opin Chem Biol 9:548-54. 2005.... - Identification of the tyrosine phosphatase PTP-MEG2 as an antagonist of hepatic insulin signalingCharles Y Cho
Genomics Institute of the Novartis Research Foundation, 10675 John Jay Hopkins Drive, San Diego, CA 92121, USA
Cell Metab 3:367-78. 2006..These data implicate PTP-MEG2 as a mediator of blood glucose homeostasis through antagonism of insulin signaling, and suggest that modulation of PTP-MEG2 activity may be an effective strategy in the treatment of type 2 diabetes... - A genetically encoded fluorescent amino acidDaniel Summerer
Department of Chemistry, The Scripps Research Institute, 10550 North Torrey Pines Road, SR202, La Jolla, CA 92037, USA
Proc Natl Acad Sci U S A 103:9785-9. 2006..The strategy described here should be applicable to a number of different fluorophores in both prokaryotic and eukaryotic organisms, and it should facilitate both biochemical and cellular studies of protein structure and function... - A chemical toolkit for proteins--an expanded genetic codeJianming Xie
Department of Chemistry and Skaggs Institute for Chemical Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, USA
Nat Rev Mol Cell Biol 7:775-82. 2006..This provides a powerful tool for exploring protein structure and function in vitro and in vivo, and for generating proteins with new or enhanced properties... - A genetically encoded diazirine photocrosslinker in Escherichia coliEric M Tippmann
Department of Chemistry and The Skaggs Institute for Chemical Biology, The Scripps Research Institute, 10550 N. Torrey Pines Rd, La Jolla, CA 92037, USA
Chembiochem 8:2210-4. 2007 - Site-specific insertion of 3-aminotyrosine into subunit alpha2 of E. coli ribonucleotide reductase: direct evidence for involvement of Y730 and Y731 in radical propagationMohammad R Seyedsayamdost
Department of Chemistry, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, Massachusetts 02139 4307, USA
J Am Chem Soc 129:15060-71. 2007..The observed NH2Y. may constitute the first detection of an amino acid radical intermediate in the proposed radical propagation pathway during turnover... - A small-molecule antagonist of the hedgehog signaling pathwayJongkook Lee
Dept. of Chemistry and The Skaggs Institute for Chemical Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, USA
Chembiochem 8:1916-9. 2007 - Inhibition of histone deacetylase activity induces developmental plasticity in oligodendrocyte precursor cellsCostas A Lyssiotis
The Skaggs Institute of Chemical Biology and Department of Chemistry, The Scripps Research Institute, 10550 North Torry Pines Road, La Jolla, CA 92037, USA
Proc Natl Acad Sci U S A 104:14982-7. 2007..This series of experiments demonstrates that global histone acetylation, induced by HDAC inhibition, can partially reverse the lineage restriction of OPCs, thereby inducing developmental plasticity... - Identification and characterization of small-molecule inducers of epidermal keratinocyte differentiationJiyong Hong
ACS Chem Biol 2:171-5. 2007.... - An improved system for the generation and analysis of mutant proteins containing unnatural amino acids in Saccharomyces cerevisiaeShawn Chen
Department of Chemistry and The Skaggs Institute for Chemical Biology, The Scripps Research Institute, La Jolla, CA 92037, USA
J Mol Biol 371:112-22. 2007..Mass spectrometric analysis of the hSOD mutants was performed with high dynamic range using multiple reaction monitoring that provided new insights into the factors that control the fidelity of unnatural amino acid incorporation... - Site-specific incorporation of methyl- and acetyl-lysine analogues into recombinant proteinsJiantao Guo
Department of Chemistry and The Skaggs Institute for Chemical Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
Angew Chem Int Ed Engl 47:6399-401. 2008 - Site-specific incorporation of the mucin-type N-acetylgalactosamine-alpha-O-threonine into protein in Escherichia coliRan Xu
Department of Chemistry, and The Skaggs Institute for Chemical Biology, The Scripps Research Institute, 10550 Torrey Pines Road, La Jolla, California 92037, USA
J Am Chem Soc 126:15654-5. 2004..coli to contain the other major O-linked glycan, N-acetylgalactosamine-alpha-O-threonine (GalNAc-a-Thr)... - Addition of the keto functional group to the genetic code of Escherichia coliLei Wang
Department of Chemistry, University of California, Berkeley 94720, USA
Proc Natl Acad Sci U S A 100:56-61. 2003..This additional genetically encoded amino acid should greatly expand our ability to manipulate protein structure and function both in vitro and in living cells... - A potent and highly selective sulfotransferase inhibitorEli Chapman
Department of Chemistry and The Skaggs Institute for Chemical Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, USA
J Am Chem Soc 124:14524-5. 2002..The most potent of these inhibitors was tested against a variety of other purine binding enzymes and showed remarkable specificity... - The selective incorporation of alkenes into proteins in Escherichia coliZhiwen Zhang
Department of Chemistry, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
Angew Chem Int Ed Engl 41:2840-2. 2002 - Gene expression during the priming phase of liver regeneration after partial hepatectomy in miceAndrew I Su
Department of Chemistry and Molecular and Experimental Medicine, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
Proc Natl Acad Sci U S A 99:11181-6. 2002..The genome-wide changes that are observed provide a detailed and comprehensive map of the initial priming stage of liver regeneration... - Profiling protein function with small molecule microarraysNicolas Winssinger
Genomics Institute of the Novartis Research Foundation, 10675 John Jay Hopkins Drive, San Diego, CA 92121, USA
Proc Natl Acad Sci U S A 99:11139-44. 2002.... - Addition of a photocrosslinking amino acid to the genetic code of EscherichiacoliJason W Chin
Department of Chemistry and The Skaggs Institute for Chemical Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
Proc Natl Acad Sci U S A 99:11020-4. 2002..Irradiation resulted in efficient crosslinking (>50%) of the protein subunits. This methodology may prove useful for discovering and defining protein interactions in vitro and in vivo... - Coordinated transcription of key pathways in the mouse by the circadian clockSatchidananda Panda
The Genomics Institute of the Novartis Research Foundation, San Diego, California 92121, USA
Cell 109:307-20. 2002..Importantly, rate-limiting steps in these various pathways were key sites of circadian control, highlighting the fundamental role that circadian clocks play in cellular and organismal physiology... - Directed evolution of the site specificity of Cre recombinaseStephen W Santoro
Department of Chemistry and The Skaggs Institute for Chemical Biology, The Scripps Research Institute, SR202, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
Proc Natl Acad Sci U S A 99:4185-90. 2002..This and other systems should contribute to our understanding of protein-DNA recognition and may eventually be used to evolve custom-tailored recombinases that can be used for gene study and inactivation... - Large-scale analysis of the human and mouse transcriptomesAndrew I Su
Department of Chemistry, The Scripps Research Institute, La Jolla, CA 92037, USA
Proc Natl Acad Sci U S A 99:4465-70. 2002..Finally, to allow the scientific community to use this resource, we have built a free and publicly accessible website (http://expression.gnf.org) that integrates data visualization and curation of current gene annotations... - Adding L-3-(2-Naphthyl)alanine to the genetic code of E. coliLei Wang
Department of Chemistry, University of California at Berkeley, Berkeley, California 94720, USA
J Am Chem Soc 124:1836-7. 2002..The expansion of the genetic code to include amino acids beyond the common 20 would provide an opportunity to better understand and possibly enhance protein (and perhaps organismal) function... - Synthetic small molecules that control stem cell fateSheng Ding
Department of Chemistry and The Skaggs Institute for Chemical Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
Proc Natl Acad Sci U S A 100:7632-7. 2003..This and such other molecules are likely to provide insights into the molecular mechanisms that control stem cell fate, and may ultimately be useful to in vivo stem cell biology and therapy... - Directed evolution of the substrate specificities of a site-specific recombinase and an aminoacyl-tRNA synthetase using fluorescence-activated cell sorting (FACS)Stephen W Santoro
Department of Chemistry and the Skaggs Instutute for Chemical Biology, The Scripps Research Institute, La Jolla, CA, USA
Methods Mol Biol 230:291-312. 2003 - An expanding genetic codeT Ashton Cropp
Department of Chemistry and Biochemistry, University of Maryland, College Park, MD 20742, USA
Trends Genet 20:625-30. 2004..Moreover, by lifting the constraints of the existing 20-amino-acid code, it should be possible to generate proteins and perhaps entire organisms with new or enhanced properties... - Substrate recognition by the AAA+ chaperone ClpBChristian Schlieker
Zentrum fur Molekulare Biologie, Universitat Heidelberg, Im Neuenheimer Feld 282, Heidelberg 69120, Germany
Nat Struct Mol Biol 11:607-15. 2004..The location of the identified binding site also suggests a possible translocation mechanism as an integral part of the ClpB-dependent disaggregation reaction... - Identification of p53 regulators by genome-wide functional analysisQihong Huang
Department of Chemistry, The Scripps Research Institute, Mail Stop SR202, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
Proc Natl Acad Sci U S A 101:3456-61. 2004..These results suggest that these transcription factors are members of an evolutionarily conserved network that governs p53 function... - A new strategy for the synthesis of glycoproteinsZhiwen Zhang
Department of Chemistry, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
Science 303:371-3. 2004..This approach should be generally applicable to other posttranslational modifications such as protein phosphorylation, acetylation, and methylation... - Dedifferentiation of lineage-committed cells by a small moleculeShuibing Chen
Department of Chemistry and The Skaggs Institute for Chemical Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, USA
J Am Chem Soc 126:410-1. 2004..This and other such molecules are likely to provide new insights into the molecular mechanisms that control cellular dedifferentiation and may ultimately be useful to in vivo stem cell biology and therapy... - Site-specific incorporation of a redox-active amino acid into proteinsLital Alfonta
Department of Chemistry and The Skaggs Institute for Chemical Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
J Am Chem Soc 125:14662-3. 2003..The ability to incorporate a redox-active amino acid site specifically into proteins should facilitate the study of electron transfer in proteins, as well as enable the engineering of redox proteins with novel properties... - Adding amino acids with novel reactivity to the genetic code of Saccharomyces cerevisiaeAlexander Deiters
Department of Chemistry, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, USA
J Am Chem Soc 125:11782-3. 2003..As an example, we have shown that proteins containing these amino acids can be efficiently bioconjugated with small organic molecules by a [3 + 2] cycloaddition reaction that is mild enough for the manipulation of biological samples... - An expanded eukaryotic genetic codeJason W Chin
Department of Chemistry and Skaggs Institute for Chemical Biology, Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
Science 301:964-7. 2003.... - Structural plasticity and the evolution of antibody affinity and specificityJun Yin
Department of Chemistry, University of California at Berkeley, Berkeley, CA 94720, USA
J Mol Biol 330:651-6. 2003.... - Progress toward an expanded eukaryotic genetic codeJason W Chin
Department of Chemistry, Skaggs Institute for Chemical Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
Chem Biol 10:511-9. 2003..This method will facilitate the isolation of a range of aminoacyl-tRNA synthetase (aaRS)/tRNA(CUA) activities from large libraries of mutant synthetases... - A combinatorial scaffold approach toward kinase-directed heterocycle librariesSheng Ding
Department of Chemistry and The Skaggs Institute for Chemical Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, USA
J Am Chem Soc 124:1594-6. 2002..Libraries consisting of discrete and highly diverse heterocyclic small molecules constructed with these chemistries are currently being evaluated in a variety of cell and protein-based assays...
Research Grants
- Nucleic Acids with Novel Structures and FunctionsPeter Schultz; Fiscal Year: 2005..In addition to the applications described above, these experiments will likely provide new insights into nucleic acid structure, function and recognition. ..
- SYNTHESIS OF CATALYTIC ANTIBODIESPeter Schultz; Fiscal Year: 2006..abstract_text> ..
- IN VIVO INCORPORATION OF UNNATURAL AMINO ACIDSPeter Schultz; Fiscal Year: 2007..These studies should dramatically expand our ability to manipulate protein structure in order to create proteins with new functions and to probe protein structure and function in vitro and in vivo. ..
- SYNTHESIS OF CATALYTIC ANTIBODIESPeter Schultz; Fiscal Year: 2007..These latter projects will provide new insights into the evolution of protein structure and function, and the role of redox processes in biological recognition and cell signaling, respectively. ..
- IN VIVO INCORPORATION OF UNNATURAL AMINO ACIDSPeter Schultz; Fiscal Year: 2007..These studies should dramatically expand our ability to manipulate protein structure in order to create proteins with new functions and to probe protein structure and function in vitro and in vivo. ..
- IN VIVO INCORPORATION OF UNNATURAL AMINO ACIDSPeter G Schultz; Fiscal Year: 2010..The result will be new tools to study protein function in vitro and in vivo. It should also be possible to create homogenous "chemically mutated" therapeutic proteins and vaccines with enhanced activities and improved pharmacology. ..
- Single Molecule Studies of BiomoleculesPeter Schultz; Fiscal Year: 2004..abstract_text> ..
- SYNTHESIS OF CATALYTIC ANTIBODIESPeter Schultz; Fiscal Year: 2003..abstract_text> ..
- IN VIVO INCORPORATION OF UNNATURAL AMINO ACIDSPeter Schultz; Fiscal Year: 2003..abstract_text> ..
- SYNTHESIS OF CATALYTIC ANTIBODIESPeter G Schultz; Fiscal Year: 2010..These latter projects will provide new insights into the evolution of protein structure and function, and the role of redox processes in biological recognition and cell signaling, respectively. ..