DAVID R SCHUBERT

Summary

Affiliation: The Salk Institute
Country: USA

Publications

  1. ncbi A different perspective on GM food
    David Schubert
    Salk Institute, 10010 N. Torrey Pines Road, La Jolla, CA 92037, USA
    Nat Biotechnol 20:969. 2002
  2. ncbi An alternative approach to drug discovery for Alzheimer's disease dementia
    David Schubert
    The Salk Institute for Biological Studies, Cellular Neurobiology Laboratory, 10010 North Torrey Pines Road, La Jolla, CA 92037 1002, USA
    Future Med Chem 4:1681-8. 2012
  3. ncbi The induction of HIF-1 reduces astrocyte activation by amyloid beta peptide
    David Schubert
    Cellular Neurobiology Laboratory, The Salk Institute, La Jolla, CA 92037, USA
    Eur J Neurosci 29:1323-34. 2009
  4. ncbi The problem with nutritionally enhanced plants
    DAVID R SCHUBERT
    Cellular Neurobiology Laboratory, The Salk Institute for Biological Studies, La Jolla, California 92037 1099, USA
    J Med Food 11:601-5. 2008
  5. ncbi Oxidative glutamate toxicity can be a component of the excitotoxicity cascade
    D Schubert
    Cellular Neurobiology Laboratory, The Salk Institute for Biological Studies, La Jolla, California 92037, USA
    J Neurosci 21:7455-62. 2001
  6. ncbi Cerium and yttrium oxide nanoparticles are neuroprotective
    David Schubert
    The Salk Institute, 10010 N Torrey Pines Rd, La Jolla, CA 92037, USA
    Biochem Biophys Res Commun 342:86-91. 2006
  7. ncbi F-spondin promotes nerve precursor differentiation
    David Schubert
    The Salk Institute, La Jolla, California 92037, USA
    J Neurochem 96:444-53. 2006
  8. ncbi Glucose metabolism and Alzheimer's disease
    David Schubert
    Cellular Neurobiology Laboratory, The Salk Institute for Biological Studies, 10010 N, Torrey Pines Road, La Jolla, CA 92037, USA
    Ageing Res Rev 4:240-57. 2005
  9. ncbi The specificity of neuroprotection by antioxidants
    Yuanbin Liu
    Cellular Neurobiology Laboratory, The Salk Institute for Biological Studies, 10010 N, Torrey Pines Road, La Jolla, California 92037 1099 USA
    J Biomed Sci 16:98. 2009
  10. ncbi Promoting basal levels of autophagy in the nervous system enhances longevity and oxidant resistance in adult Drosophila
    Anne Simonsen
    Cellular Neurobiology Laboratory, The Salk Institute for Biological Studies, La Jolla, California 92037, USA
    Autophagy 4:176-84. 2008

Research Grants

  1. A Novel Family of Neuroprotective Compounds for Stroke
    DAVID R SCHUBERT; Fiscal Year: 2010
  2. PHYSIOLOGY OF NERVE, GLIAL AND MUSCLE CELL LINES
    David Schubert; Fiscal Year: 2005
  3. Redox Sensitive Proteins in Aging and Neurodegeneration
    David Schubert; Fiscal Year: 2006
  4. Development and Testing of a Novel Neuroprotective Drug
    David Schubert; Fiscal Year: 2006
  5. Regulation of APP Degradation and ABeta Secretion
    David Schubert; Fiscal Year: 2007
  6. PHYSIOLOGY OF NERVE, GLIAL, AND MUSCLE CELL LINES
    David Schubert; Fiscal Year: 1999
  7. PHYSIOLOGY OF NERVE, GLIAL, AND MUSCLE CELL LINES
    David Schubert; Fiscal Year: 1993
  8. PHYSIOLOGY OF NERVE, GLIAL AND MUSCLE CELL LINES
    David Schubert; Fiscal Year: 1992
  9. PHYSIOLOGY OF NERVE, GLIAL, AND MUSCLE CELL LINES
    David Schubert; Fiscal Year: 1980
  10. Pan-Lipoxygenase Inhibitors for CNS Disease
    DAVID R SCHUBERT; Fiscal Year: 2010

Collaborators

Detail Information

Publications11

  1. ncbi A different perspective on GM food
    David Schubert
    Salk Institute, 10010 N. Torrey Pines Road, La Jolla, CA 92037, USA
    Nat Biotechnol 20:969. 2002
  2. ncbi An alternative approach to drug discovery for Alzheimer's disease dementia
    David Schubert
    The Salk Institute for Biological Studies, Cellular Neurobiology Laboratory, 10010 North Torrey Pines Road, La Jolla, CA 92037 1002, USA
    Future Med Chem 4:1681-8. 2012
    ..This approach to neurodegenerative disease drug discovery is likely to produce safe and effective drugs...
  3. ncbi The induction of HIF-1 reduces astrocyte activation by amyloid beta peptide
    David Schubert
    Cellular Neurobiology Laboratory, The Salk Institute, La Jolla, CA 92037, USA
    Eur J Neurosci 29:1323-34. 2009
    ..They may also explain the therapeutic success of metal chelators in animal models of AD...
  4. ncbi The problem with nutritionally enhanced plants
    DAVID R SCHUBERT
    Cellular Neurobiology Laboratory, The Salk Institute for Biological Studies, La Jolla, California 92037 1099, USA
    J Med Food 11:601-5. 2008
    ..This will require a mandatory, scientifically rigorous review process...
  5. ncbi Oxidative glutamate toxicity can be a component of the excitotoxicity cascade
    D Schubert
    Cellular Neurobiology Laboratory, The Salk Institute for Biological Studies, La Jolla, California 92037, USA
    J Neurosci 21:7455-62. 2001
    ..These results suggest that oxidative glutamate toxicity toward neurons lacking functional NMDA receptors can be a component of the excitotoxicity-initiated cell death pathway...
  6. ncbi Cerium and yttrium oxide nanoparticles are neuroprotective
    David Schubert
    The Salk Institute, 10010 N Torrey Pines Rd, La Jolla, CA 92037, USA
    Biochem Biophys Res Commun 342:86-91. 2006
    ..It follows that this group of nanoparticles could be used to modulate oxidative stress in biological systems...
  7. ncbi F-spondin promotes nerve precursor differentiation
    David Schubert
    The Salk Institute, La Jolla, California 92037, USA
    J Neurochem 96:444-53. 2006
    ..Therefore, F-spondin can alter cell differentiation in multiple ways, depending upon its concentration and distribution between substrate-attached and soluble forms...
  8. ncbi Glucose metabolism and Alzheimer's disease
    David Schubert
    Cellular Neurobiology Laboratory, The Salk Institute for Biological Studies, 10010 N, Torrey Pines Road, La Jolla, CA 92037, USA
    Ageing Res Rev 4:240-57. 2005
    ..This shift is at least in part mediated by the transcription factor HIF-1. The clinical implications of this change in glucose metabolism are discussed in the context of aging and Alzheimer's disease...
  9. ncbi The specificity of neuroprotection by antioxidants
    Yuanbin Liu
    Cellular Neurobiology Laboratory, The Salk Institute for Biological Studies, 10010 N, Torrey Pines Road, La Jolla, California 92037 1099 USA
    J Biomed Sci 16:98. 2009
    ..The aim of this study is to examine the specificity of the interaction between the antioxidants and ROS production in stressed cells...
  10. ncbi Promoting basal levels of autophagy in the nervous system enhances longevity and oxidant resistance in adult Drosophila
    Anne Simonsen
    Cellular Neurobiology Laboratory, The Salk Institute for Biological Studies, La Jolla, California 92037, USA
    Autophagy 4:176-84. 2008
    ....
  11. ncbi Metabolic links between diabetes and Alzheimer's disease
    Pamela A Maher
    Cellular Neurobiology Laboratory, The Salk Institute for Biological Studies, La Jolla, CA 92037 1099, USA
    Expert Rev Neurother 9:617-30. 2009
    ..It is therefore likely that the only successful therapy will involve the use of drugs with multiple targets in concert with changes in diet and lifestyle...

Research Grants38

  1. A Novel Family of Neuroprotective Compounds for Stroke
    DAVID R SCHUBERT; Fiscal Year: 2010
    ..abstract_text> ..
  2. PHYSIOLOGY OF NERVE, GLIAL AND MUSCLE CELL LINES
    David Schubert; Fiscal Year: 2005
    ..This work is directly relevant to CNS trauma and stroke as well as to all chronic degenerative diseases where oxidative stress is a pathological hallmark. ..
  3. Redox Sensitive Proteins in Aging and Neurodegeneration
    David Schubert; Fiscal Year: 2006
    ..These proteins, in turn, will be used as targets for the identification of potentially therapeutic antioxidants that could be useful in preventing age-and disease-associated damage to the CNS. ..
  4. Development and Testing of a Novel Neuroprotective Drug
    David Schubert; Fiscal Year: 2006
    ..The results from these studies will determine the therapeutic potential of this novel compound. ..
  5. Regulation of APP Degradation and ABeta Secretion
    David Schubert; Fiscal Year: 2007
    ..In addition, understanding how cells regulate the degradation of proteins is critical to the study of a wide range of diseases, particularly those in the nervous system that are characterized by the intracellular protein accumulation. ..
  6. PHYSIOLOGY OF NERVE, GLIAL, AND MUSCLE CELL LINES
    David Schubert; Fiscal Year: 1999
    ..The experiments in this proposal should help define the role of protein growth factors in the developing nervous system. Hopefully, this information will lead to a treatment for some neurodegenerative diseases and CNS trauma. ..
  7. PHYSIOLOGY OF NERVE, GLIAL, AND MUSCLE CELL LINES
    David Schubert; Fiscal Year: 1993
    ..The experiments in this proposal should help define the role of protein growth factors in the developing nervous system. Hopefully, this information will lead to a treatment for some neurodegenerative diseases and CNS trauma...
  8. PHYSIOLOGY OF NERVE, GLIAL AND MUSCLE CELL LINES
    David Schubert; Fiscal Year: 1992
    ..The extracellular molecules released by regenerating sciatic nerve in vivo will be studied with respect to their effects on Schwann cell migraton, adhesion, and differentiation...
  9. PHYSIOLOGY OF NERVE, GLIAL, AND MUSCLE CELL LINES
    David Schubert; Fiscal Year: 1980
    ..The role of extracellular substrate attached material in cell-cell and cell-substratum adhesion will also be studied. ..
  10. Pan-Lipoxygenase Inhibitors for CNS Disease
    DAVID R SCHUBERT; Fiscal Year: 2010
    ..To push these drugs to the clinic and to identify more and perhaps better therapeutic targets, we need to understand exactly how these drugs function, and that is the goal of this proposal. ..