Jeffry D Schroeter

Summary

Affiliation: The Hamner Institutes for Health Sciences
Country: USA

Publications

  1. ncbi request reprint Application of physiological computational fluid dynamics models to predict interspecies nasal dosimetry of inhaled acrolein
    Jeffry D Schroeter
    The Hamner Institutes for Health Sciences, Research Triangle Park, North Carolina 27709 2137, USA
    Inhal Toxicol 20:227-43. 2008
  2. doi request reprint A computational fluid dynamics approach to assess interhuman variability in hydrogen sulfide nasal dosimetry
    Jeffry D Schroeter
    The Hamner Institutes for Health Sciences, Research Triangle Park, North Carolina 27709 2137, USA
    Inhal Toxicol 22:277-86. 2010
  3. doi request reprint Analysis of manganese tracer kinetics and target tissue dosimetry in monkeys and humans with multi-route physiologically based pharmacokinetic models
    Jeffry D Schroeter
    The Hamner Institutes for Health Sciences, Research Triangle Park, North Carolina 27709 2137, USA
    Toxicol Sci 120:481-98. 2011
  4. ncbi request reprint Risk assessment dosimetry model for inhaled particulate matter: II. Laboratory surrogates (rat)
    Ted B Martonen
    Experimental Toxicology Division, National Health and Environmental Effects Research Laboratory, US Environmental Protection Agency, Mail Drop 74, 86 T W Alexander Drive, Research Triangle Park, NC 27711, USA
    Toxicol Lett 138:133-42. 2003
  5. ncbi request reprint Use of a pharmacokinetic-driven computational fluid dynamics model to predict nasal extraction of hydrogen sulfide in rats and humans
    Jeffry D Schroeter
    CIIT Centers for Health Research, Research Triangle Park, North Carolina 27709 2137, USA
    Toxicol Sci 94:359-67. 2006
  6. doi request reprint Application of a multi-route physiologically based pharmacokinetic model for manganese to evaluate dose-dependent neurological effects in monkeys
    Jeffry D Schroeter
    The Hamner Institutes for Health Sciences, Research Triangle Park, North Carolina, USA
    Toxicol Sci 129:432-46. 2012
  7. ncbi request reprint Incorporation of tissue reaction kinetics in a computational fluid dynamics model for nasal extraction of inhaled hydrogen sulfide in rats
    Jeffry D Schroeter
    CIIT Centers for Health Research, 6 Davis Drive, P O Box 12137, Research Triangle Park, North Carolina 27709 2137, USA
    Toxicol Sci 90:198-207. 2006
  8. doi request reprint Physiologically based pharmacokinetic modeling of fetal and neonatal manganese exposure in humans: describing manganese homeostasis during development
    Miyoung Yoon
    Center for Human Health Assessment, The Hamner Institutes for Health Sciences, Research Triangle Park, North Carolina 27709, USA
    Toxicol Sci 122:297-316. 2011
  9. ncbi request reprint Nasal uptake of inhaled acrolein in rats
    Melanie F Struve
    CIIT at The Hamner Institutes for Health Sciences, Research Triangle Park, North Carolina, USA
    Inhal Toxicol 20:217-25. 2008
  10. ncbi request reprint Analysis of particle deposition in the turbinate and olfactory regions using a human nasal computational fluid dynamics model
    Jeffry D Schroeter
    CIIT Centers for Health Research, Research Triangle Park, North Carolina, 27709 2137, USA
    J Aerosol Med 19:301-13. 2006

Detail Information

Publications16

  1. ncbi request reprint Application of physiological computational fluid dynamics models to predict interspecies nasal dosimetry of inhaled acrolein
    Jeffry D Schroeter
    The Hamner Institutes for Health Sciences, Research Triangle Park, North Carolina 27709 2137, USA
    Inhal Toxicol 20:227-43. 2008
    ..Assuming that equivalent tissue dose will induce similar effects across species, a NOAEL human equivalent concentration for inhaled acrolein was estimated to be 8 ppb...
  2. doi request reprint A computational fluid dynamics approach to assess interhuman variability in hydrogen sulfide nasal dosimetry
    Jeffry D Schroeter
    The Hamner Institutes for Health Sciences, Research Triangle Park, North Carolina 27709 2137, USA
    Inhal Toxicol 22:277-86. 2010
    ..These preliminary results suggest that differences in nasal anatomy and ventilation among adults and children do not have a significant effect on H(2)S dosimetry in the olfactory region...
  3. doi request reprint Analysis of manganese tracer kinetics and target tissue dosimetry in monkeys and humans with multi-route physiologically based pharmacokinetic models
    Jeffry D Schroeter
    The Hamner Institutes for Health Sciences, Research Triangle Park, North Carolina 27709 2137, USA
    Toxicol Sci 120:481-98. 2011
    ....
  4. ncbi request reprint Risk assessment dosimetry model for inhaled particulate matter: II. Laboratory surrogates (rat)
    Ted B Martonen
    Experimental Toxicology Division, National Health and Environmental Effects Research Laboratory, US Environmental Protection Agency, Mail Drop 74, 86 T W Alexander Drive, Research Triangle Park, NC 27711, USA
    Toxicol Lett 138:133-42. 2003
    ..The findings of our work clearly demonstrate that interspecies simulations can be employed to design animal tests a priori so that the results can be effectively and efficiently extrapolated to human conditions in a meaningful manner...
  5. ncbi request reprint Use of a pharmacokinetic-driven computational fluid dynamics model to predict nasal extraction of hydrogen sulfide in rats and humans
    Jeffry D Schroeter
    CIIT Centers for Health Research, Research Triangle Park, North Carolina 27709 2137, USA
    Toxicol Sci 94:359-67. 2006
    ....
  6. doi request reprint Application of a multi-route physiologically based pharmacokinetic model for manganese to evaluate dose-dependent neurological effects in monkeys
    Jeffry D Schroeter
    The Hamner Institutes for Health Sciences, Research Triangle Park, North Carolina, USA
    Toxicol Sci 129:432-46. 2012
    ..These results also provide strong evidence of a dose-dependent transition in the mode of action for the neurological effects of Mn that needs to be considered in risk assessments for this essential metal...
  7. ncbi request reprint Incorporation of tissue reaction kinetics in a computational fluid dynamics model for nasal extraction of inhaled hydrogen sulfide in rats
    Jeffry D Schroeter
    CIIT Centers for Health Research, 6 Davis Drive, P O Box 12137, Research Triangle Park, North Carolina 27709 2137, USA
    Toxicol Sci 90:198-207. 2006
    ..The CFD model provides estimates of localized H2S flux to airway walls and can be used to calibrate lesion sites by dose...
  8. doi request reprint Physiologically based pharmacokinetic modeling of fetal and neonatal manganese exposure in humans: describing manganese homeostasis during development
    Miyoung Yoon
    Center for Human Health Assessment, The Hamner Institutes for Health Sciences, Research Triangle Park, North Carolina 27709, USA
    Toxicol Sci 122:297-316. 2011
    ..This PBPK approach can assess expected Mn tissue concentration during early life and compares contributions of different Mn sources, such as breast or cow milk, formula, food, drinking water, and inhalation, with tissue concentration...
  9. ncbi request reprint Nasal uptake of inhaled acrolein in rats
    Melanie F Struve
    CIIT at The Hamner Institutes for Health Sciences, Research Triangle Park, North Carolina, USA
    Inhal Toxicol 20:217-25. 2008
    ....
  10. ncbi request reprint Analysis of particle deposition in the turbinate and olfactory regions using a human nasal computational fluid dynamics model
    Jeffry D Schroeter
    CIIT Centers for Health Research, Research Triangle Park, North Carolina, 27709 2137, USA
    J Aerosol Med 19:301-13. 2006
    ....
  11. doi request reprint Dosimetry of nasal uptake of water-soluble and reactive gases: a first study of interhuman variability
    Guilherme J M Garcia
    The Hamner Institutes for Health Sciences, 6 Davis Drive, Research Triangle Park, NC 27709, USA
    Inhal Toxicol 21:607-18. 2009
    ..6-fold among the 7 individuals studied. Children and adults displayed very similar patterns of nasal gas uptake; no significant differences were noted between the two age groups...
  12. ncbi request reprint Risk assessment dosimetry model for inhaled particulate matter: I. Human subjects
    Ted B Martonen
    Experimental Toxicology Division, National Health and Environmental Effects Research Laboratory, US Environmental Protection Agency, Research Triangle Park, NC 27711, USA
    Toxicol Lett 138:119-32. 2003
    ..We propose, therefore, that mathematical models be used in a complementary manner with inhalation exposure experiments and be actively integrated into PM risk assessment protocols...
  13. ncbi request reprint Characterization of deposition from nasal spray devices using a computational fluid dynamics model of the human nasal passages
    Julia S Kimbell
    The Hamner Institutes for Health Sciences
    J Aerosol Med 20:59-74. 2007
    ..These predictions contribute to more effective design of drug delivery devices through a better understanding of the effects of nasal airflow and spray characteristics on particle transport in the nose...
  14. ncbi request reprint Airway identification within planar gamma camera images using computer models of lung morphology
    Jeffry D Schroeter
    Curriculum in Toxicology, University of North Carolina, Chapel Hill, North Carolina, USA
    Pharm Res 22:1692-9. 2005
    ..Herein, a computer modeling technique of the three-dimensional (3-D) branching structure of human lung airways was applied to assist in the interpretation of planar gamma camera images...
  15. ncbi request reprint Factors affecting the deposition of inhaled porous drug particles
    Cynthia J Musante
    Entelos, Inc, Menlo Park, California 94025, USA
    J Pharm Sci 91:1590-600. 2002
    ....
  16. ncbi request reprint A computer model of lung morphology to analyze SPECT images
    Jeffry D Schroeter
    Curriculum in Toxicology, University of North Carolina, Chapel Hill, NC 27599, USA
    Comput Med Imaging Graph 26:237-46. 2002
    ..The computer models serve as customized templates, which when analyzed alongside gamma scintigraphy images, can assist in the interpretation of human test data...