Daniel Schoenberg

Summary

Affiliation: The Ohio State University
Country: USA

Publications

  1. pmc SMG6 cleavage generates metastable decay intermediates from nonsense-containing β-globin mRNA
    Roshan Mascarenhas
    Center for RNA Biology, The Ohio State University, Columbus, Ohio, United States of America Department of Molecular and Cellular Biochemistry, The Ohio State University, Columbus, Ohio, United States of America
    PLoS ONE 8:e74791. 2013
  2. pmc Regulation of cytoplasmic mRNA decay
    Daniel R Schoenberg
    Department of Molecular and Cellular Biochemistry and Center for RNA Biology, The Ohio State University, Columbus, Ohio 43210, USA
    Nat Rev Genet 13:246-59. 2012
  3. pmc KSRP-PMR1-exosome association determines parathyroid hormone mRNA levels and stability in transfected cells
    Morris Nechama
    Minerva Center for Calcium and Bone Metabolism, Nephrology Services, Hadassah Hebrew University Medical Center, Jerusalem, Israel
    BMC Cell Biol 10:70. 2009
  4. pmc Mechanisms of endonuclease-mediated mRNA decay
    Daniel R Schoenberg
    Center for RNA Biology and Department of Molecular and Cellular Biochemistry, The Ohio State University, Columbus, OH, USA
    Wiley Interdiscip Rev RNA 2:582-600. 2011
  5. pmc Re-capping the message
    Daniel R Schoenberg
    Department of Molecular and Cellular Biochemistry and Center for RNA Biology, The Ohio State University, Columbus, OH 43210, USA
    Trends Biochem Sci 34:435-42. 2009
  6. ncbi request reprint Characterization of mRNA endonucleases
    D R Schoenberg
    Department of Pharmacology, Ohio State University College of Medicine, Columbus, Ohio 43210 1239, USA
    Methods 17:60-73. 1999
  7. ncbi request reprint Endonuclease-mediated mRNA decay involves the selective targeting of PMR1 to polyribosome-bound substrate mRNA
    Feng Yang
    Department of Molecular and Cellular Biochemistry, The Ohio State Biochemistry Program, The Comprehensive Cancer Center, The Ohio State University, Columbus, OH 43210, USA
    Mol Cell 14:435-45. 2004
  8. pmc The 90-kDa heat shock protein stabilizes the polysomal ribonuclease 1 mRNA endonuclease to degradation by the 26S proteasome
    Yong Peng
    Department of Molecular and Cellular Biochemistry, RNA Group and the Comprehensive Cancer Center, The Ohio State University, Columbus, OH 43210, USA
    Mol Biol Cell 19:546-52. 2008
  9. pmc U2AF modulates poly(A) length control by the poly(A)-limiting element
    Haidong Gu
    Department of Molecular and Cellular Biochemistry and the Comprehensive Cancer Center, The Ohio State University, Columbus, OH 43210, USA
    Nucleic Acids Res 31:6264-71. 2003
  10. pmc The poly(A)-limiting element enhances mRNA accumulation by increasing the efficiency of pre-mRNA 3' processing
    Jing Peng
    Department of Molecular and Cellular Biochemistry, The Ohio State University, Columbus, 43210 1218, USA
    RNA 11:958-65. 2005

Research Grants

  1. REGULATED POLYADENYLATION OF MESSENGER RNA
    Daniel Schoenberg; Fiscal Year: 2004
  2. HORMONAL REGULATION OF MRNA STABILITY
    Daniel Schoenberg; Fiscal Year: 2004
  3. Beta-globin mRNA decay in erythroid cells
    Daniel Schoenberg; Fiscal Year: 2005
  4. HORMONAL REGULATION OF MRNA STABILITY
    Daniel Schoenberg; Fiscal Year: 2005
  5. HORMONAL REGULATION OF MRNA STABILITY
    Daniel Schoenberg; Fiscal Year: 2006
  6. HORMONAL REGULATION OF MRNA STABILITY
    Daniel Schoenberg; Fiscal Year: 2007
  7. HORMONAL REGULATION OF MRNA STABILITY
    Daniel Schoenberg; Fiscal Year: 2007
  8. Nonsense codon activation of endonuclease-mediated mRNA decay
    Daniel Schoenberg; Fiscal Year: 2009
  9. Nonsense codon activation of endonuclease-mediated mRNA decay
    Daniel R Schoenberg; Fiscal Year: 2010
  10. HORMONAL REGULATION OF MESSENGER RNA STABILITY
    Daniel R Schoenberg; Fiscal Year: 2010

Collaborators

  • LYNNE MAQUAT
  • Elizabeth L Murray
  • Yong Peng
  • Yuichi Otsuka
  • Jing Peng
  • Roshan Mascarenhas
  • Stephen J Kolb
  • Morris Nechama
  • Xiaoqiang Liu
  • Feng Yang
  • Haidong Gu
  • Julie A Dougherty
  • Scott Sutton
  • Paola Briata
  • Madhubanti Sarkar
  • Roberto Gherzi
  • Nancy L Kedersha
  • Osnat Bell
  • Tally Naveh-Many

Detail Information

Publications19

  1. pmc SMG6 cleavage generates metastable decay intermediates from nonsense-containing β-globin mRNA
    Roshan Mascarenhas
    Center for RNA Biology, The Ohio State University, Columbus, Ohio, United States of America Department of Molecular and Cellular Biochemistry, The Ohio State University, Columbus, Ohio, United States of America
    PLoS ONE 8:e74791. 2013
    ..Importantly, none of these altered the phosphorylation state of Upf1. These data provide the first proof for accumulation of stable NMD products by SMG6 endonuclease cleavage. ..
  2. pmc Regulation of cytoplasmic mRNA decay
    Daniel R Schoenberg
    Department of Molecular and Cellular Biochemistry and Center for RNA Biology, The Ohio State University, Columbus, Ohio 43210, USA
    Nat Rev Genet 13:246-59. 2012
    ..This Review examines our current understanding of how mammalian cell mRNA decay is controlled by different signalling pathways and lays out a framework for future research...
  3. pmc KSRP-PMR1-exosome association determines parathyroid hormone mRNA levels and stability in transfected cells
    Morris Nechama
    Minerva Center for Calcium and Bone Metabolism, Nephrology Services, Hadassah Hebrew University Medical Center, Jerusalem, Israel
    BMC Cell Biol 10:70. 2009
    ..AUF1 and Unr stabilize PTH mRNA while KSRP, recruiting the exoribonucleolytic complex exosome, promotes PTH mRNA decay...
  4. pmc Mechanisms of endonuclease-mediated mRNA decay
    Daniel R Schoenberg
    Center for RNA Biology and Department of Molecular and Cellular Biochemistry, The Ohio State University, Columbus, OH, USA
    Wiley Interdiscip Rev RNA 2:582-600. 2011
    ....
  5. pmc Re-capping the message
    Daniel R Schoenberg
    Department of Molecular and Cellular Biochemistry and Center for RNA Biology, The Ohio State University, Columbus, OH 43210, USA
    Trends Biochem Sci 34:435-42. 2009
    ..Furthermore, a cytoplasmic form of capping enzyme was recently identified that, together with a novel kinase, generates capped ends from cleaved RNAs. These and other findings provide evidence for re-capping and its possible functions...
  6. ncbi request reprint Characterization of mRNA endonucleases
    D R Schoenberg
    Department of Pharmacology, Ohio State University College of Medicine, Columbus, Ohio 43210 1239, USA
    Methods 17:60-73. 1999
    ....
  7. ncbi request reprint Endonuclease-mediated mRNA decay involves the selective targeting of PMR1 to polyribosome-bound substrate mRNA
    Feng Yang
    Department of Molecular and Cellular Biochemistry, The Ohio State Biochemistry Program, The Comprehensive Cancer Center, The Ohio State University, Columbus, OH 43210, USA
    Mol Cell 14:435-45. 2004
    ..Thus, endonuclease-mediated mRNA decay occurs on a polysome-bound complex containing PMR1 and its substrate mRNA...
  8. pmc The 90-kDa heat shock protein stabilizes the polysomal ribonuclease 1 mRNA endonuclease to degradation by the 26S proteasome
    Yong Peng
    Department of Molecular and Cellular Biochemistry, RNA Group and the Comprehensive Cancer Center, The Ohio State University, Columbus, OH 43210, USA
    Mol Biol Cell 19:546-52. 2008
    ..We present a model where Hsp90 interacts transiently to stabilize PMR1 in a manner similar to its interaction with c-Src, thus facilitating the tyrosine phosphorylation and targeting of PMR1 to polysomes...
  9. pmc U2AF modulates poly(A) length control by the poly(A)-limiting element
    Haidong Gu
    Department of Molecular and Cellular Biochemistry and the Comprehensive Cancer Center, The Ohio State University, Columbus, OH 43210, USA
    Nucleic Acids Res 31:6264-71. 2003
    ..This reverted to a discrete, <20 nt poly(A) tail in cells expressing U2AF65. Our results suggest that U2AF modulates the function of the PLE, perhaps by facilitating the binding of another protein to the element...
  10. pmc The poly(A)-limiting element enhances mRNA accumulation by increasing the efficiency of pre-mRNA 3' processing
    Jing Peng
    Department of Molecular and Cellular Biochemistry, The Ohio State University, Columbus, 43210 1218, USA
    RNA 11:958-65. 2005
    ..In addition, they show that PLE-containing mRNA with a <20-nt poly(A) tail is as stable as mRNA with a 100- to 200-nt poly(A) tail...
  11. pmc A+U-rich instability elements differentially activate 5'-3' and 3'-5' mRNA decay
    Elizabeth L Murray
    Department of Molecular and Cellular Biochemistry, The Ohio State University, 1645 Neil Ave, Columbus, OH 43210 1218, USA
    Mol Cell Biol 27:2791-9. 2007
    ..In contrast, the GM-CSF ARE activated decay primarily from the mRNA 5' end. These data were supported by reciprocal RNA interference knockdowns, and we present evidence that the 5'-3' and 3'-5' decay pathways are functionally linked...
  12. pmc RNA processing defects associated with diseases of the motor neuron
    Stephen J Kolb
    Department of Neurology, Ohio State University Medical Center, Hamilton Hall, Room 337B, 1645 Neil Avenue, Columbus, Ohio 43210 1228, USA
    Muscle Nerve 41:5-17. 2010
    ..This review provides a summary of currently recognized RNA processing defects linked to human motor neuron diseases...
  13. pmc Identification of a cytoplasmic complex that adds a cap onto 5'-monophosphate RNA
    Yuichi Otsuka
    Department of Molecular and Cellular Biochemistry, The Ohio State University, Columbus, OH 43210 1218, USA
    Mol Cell Biol 29:2155-67. 2009
    ....
  14. pmc The cytoskeleton-associated Ena/VASP proteins are unanticipated partners of the PMR1 mRNA endonuclease
    Yong Peng
    Department of Molecular and Cellular Biochemistry, The Ohio State University, Columbus, 43210, USA
    RNA 15:576-87. 2009
    ..Under these conditions xPMR60 colocalizes with VASP along one edge of the cell...
  15. pmc Assays for determining poly(A) tail length and the polarity of mRNA decay in mammalian cells
    Elizabeth L Murray
    Department of Molecular and Cellular Biochemistry and The RNA Group, The Ohio State University, Columbus, Ohio, USA
    Methods Enzymol 448:483-504. 2008
    ..Finally, it requires only a short sequence for target recognition and quantitation. Therefore, it can be applied to determining the decay polarity of a mRNA by measuring the decay rates of different portions of that mRNA...
  16. pmc c-Src activates endonuclease-mediated mRNA decay
    Yong Peng
    Department of Molecular and Cellular Biochemistry, The RNA Group and the Comprehensive Cancer Center, The Ohio State University, Columbus, OH 43210, USA
    Mol Cell 25:779-87. 2007
    ..Similarly, only active c-Src induces PMR1-mediated mRNA decay. Finally, we show that EGF rapidly induces c-Src phosphorylation of PMR1, providing a direct link between tyrosine kinase-mediated signal transduction and mRNA decay...
  17. pmc Application of the Invader RNA assay to the polarity of vertebrate mRNA decay
    Elizabeth L Murray
    Department of Molecular and Cellular Biochemistry, The Ohio State University, Columbus, OH, USA
    Methods Mol Biol 419:259-76. 2008
    ....
  18. pmc In vivo and in vitro analysis of poly(A) length effects on mRNA translation
    Jing Peng
    Department of Molecular and Cellular Biochemistry, The Ohio State University, Columbus, OH, USA
    Methods Mol Biol 419:215-30. 2008
    ..This approach is particularly useful for characterizing cis-acting elements that work in conjunction with poly(A) in regulating translation...
  19. pmc Approaches for studying PMR1 endonuclease-mediated mRNA decay
    Yuichi Otsuka
    Department of Molecular and Cellular Biochemistry and The RNA Group, The Ohio State University, Columbus, Ohio, USA
    Methods Enzymol 448:241-63. 2008
    ..Although the various techniques described here have proven their usefulness in studying PMR1, they can be generalized to studying decay by any other mRNA endonuclease...

Research Grants28

  1. REGULATED POLYADENYLATION OF MESSENGER RNA
    Daniel Schoenberg; Fiscal Year: 2004
    ....
  2. HORMONAL REGULATION OF MRNA STABILITY
    Daniel Schoenberg; Fiscal Year: 2004
    ..abstract_text> ..
  3. Beta-globin mRNA decay in erythroid cells
    Daniel Schoenberg; Fiscal Year: 2005
    ..The long-term goal is to identify new therapeutic targets for treating beta-thalassemia and other diseases caused by PTCs by better understanding the enzymatic mechanisms responsible for the degradation of PTC-containing mRNAs. ..
  4. HORMONAL REGULATION OF MRNA STABILITY
    Daniel Schoenberg; Fiscal Year: 2005
    ....
  5. HORMONAL REGULATION OF MRNA STABILITY
    Daniel Schoenberg; Fiscal Year: 2006
    ....
  6. HORMONAL REGULATION OF MRNA STABILITY
    Daniel Schoenberg; Fiscal Year: 2007
    ....
  7. HORMONAL REGULATION OF MRNA STABILITY
    Daniel Schoenberg; Fiscal Year: 2007
    ..abstract_text> ..
  8. Nonsense codon activation of endonuclease-mediated mRNA decay
    Daniel Schoenberg; Fiscal Year: 2009
    ..This research seeks to understand how these defective gene products are destroyed and how this information might be used to develop new treatments for this debilitating disease. ..
  9. Nonsense codon activation of endonuclease-mediated mRNA decay
    Daniel R Schoenberg; Fiscal Year: 2010
    ..This research seeks to understand how these defective gene products are destroyed and how this information might be used to develop new treatments for this debilitating disease. ..
  10. HORMONAL REGULATION OF MESSENGER RNA STABILITY
    Daniel R Schoenberg; Fiscal Year: 2010
    ..This research seeks to identify the components of the PMR1 decay complex, identify the scope of PMR1-mediated decay and relate both of these to the invasive growth of cancer cells. ..
  11. Relationship of Cytoplasmic Capping to Post-transcriptional Gene Regulation
    Daniel R Schoenberg; Fiscal Year: 2010
    ..This proposal examines cytoplasmic capping as a new regulatory process with broad implications for post- transcriptional gene regulation, RNA silencing and translational control. ..
  12. REGULATED POLYADENYLATION OF MESSENGER RNA
    Daniel Schoenberg; Fiscal Year: 2003
    ....
  13. HORMONAL REGULATION OF MRNA STABILITY
    Daniel Schoenberg; Fiscal Year: 2003
    ..abstract_text> ..
  14. POLYADENYLATION OF AN ESTROGEN REGULATED MESSENGER RNA
    Daniel Schoenberg; Fiscal Year: 1999
    ....
  15. HORMONAL REGULATION OF MESSENGER RNA STABILITY
    Daniel Schoenberg; Fiscal Year: 1999
    ....
  16. HORMONAL REGULATION OF MESSENGER RNA STABILITY
    Daniel Schoenberg; Fiscal Year: 2000
    ....
  17. POLYADENYLATION OF AN ESTROGEN REGULATED MESSENGER RNA
    Daniel Schoenberg; Fiscal Year: 2000
    ....
  18. REGULATED POLYADENYLATION OF MESSENGER RNA
    Daniel Schoenberg; Fiscal Year: 2001
    ....
  19. HORMONAL REGULATION OF MRNA STABILITY
    Daniel Schoenberg; Fiscal Year: 2001
    ..abstract_text> ..
  20. REGULATED POLYADENYLATION OF MESSENGER RNA
    Daniel Schoenberg; Fiscal Year: 2002
    ....
  21. HORMONAL REGULATION OF MRNA STABILITY
    Daniel Schoenberg; Fiscal Year: 2002
    ..abstract_text> ..
  22. HORMONAL REGULATION OF MRNA STABILITY
    Daniel Schoenberg; Fiscal Year: 2009
    ....