Narine Sarvazyan

Summary

Affiliation: The George Washington University
Country: USA

Publications

  1. pmc Interaction between spiral and paced waves in cardiac tissue
    Konstantin Agladze
    Pharmacology and Physiology Department, The George Washington University, 2300 Eye Street, Washington, DC 20037
    Am J Physiol Heart Circ Physiol 293:H503-13. 2007
  2. pmc Phthalate exposure changes the metabolic profile of cardiac muscle cells
    Nikki Gillum Posnack
    Department of Pharmacology and Physiology, The George Washington University, Washington, DC, USA
    Environ Health Perspect 120:1243-51. 2012
  3. pmc Clinically relevant concentrations of di (2-ethylhexyl) phthalate (DEHP) uncouple cardiac syncytium
    Nikki Gillum
    Pharmacology and Physiology Department, The George Washington University, 2300 Eye Street, Washington, DC 20037, USA
    Toxicol Appl Pharmacol 236:25-38. 2009
  4. pmc Adhesion proteins, stem cells, and arrhythmogenesis
    Nikki Gillum
    Pharmacology and Physiology Department, The George Washington University, 2300 Eye Street, Washington, DC 20037, USA
    Cardiovasc Toxicol 8:1-13. 2008
  5. pmc Preprocessing of fluoresced transmembrane potential signals for cardiac optical mapping
    Huda Asfour
    The George Washington University, Washington, DC 20052, USA
    Conf Proc IEEE Eng Med Biol Soc 2011:227-30. 2011
  6. pmc Immunological barriers to stem-cell based cardiac repair
    Zaruhi Karabekian
    Pharmacology and Physiology Department, The George Washington University, 2300 Eye Street, Washington, DC 20037, USA
    Stem Cell Rev 7:315-25. 2011
  7. doi request reprint Development of an undergraduate pharmacogenomics curriculum
    Travis J O'Brien
    The George Washington University Medical Center, Ross Hall Room 660A, 2300 Eye Street, NW, Washington, DC 20037, USA
    Pharmacogenomics 10:1979-86. 2009
  8. pmc Exposure to phthalates affects calcium handling and intercellular connectivity of human stem cell-derived cardiomyocytes
    Nikki Gillum Posnack
    Department of Pharmacology and Physiology, The George Washington University, Washington, DC, United States of America
    PLoS ONE 10:e0121927. 2015
  9. pmc Physiological response of cardiac tissue to bisphenol A: alterations in ventricular pressure and contractility
    Nikki Gillum Posnack
    Department of Pharmacology and Physiology, School of Medicine and Health Sciences, The George Washington University, Washington, District of Columbia and
    Am J Physiol Heart Circ Physiol 309:H267-75. 2015
  10. pmc Properties of blebbistatin for cardiac optical mapping and other imaging applications
    Luther M Swift
    Department of Pharmacology and Physiology, The George Washington University Medical Center, 2300 Eye Street, Washington, DC 20037, USA
    Pflugers Arch 464:503-12. 2012

Collaborators

  • Matthew W Kay
  • Huda Asfour
  • Michael A Laflamme
  • Travis J O'Brien
  • H G Mandel
  • Norman H Lee
  • Federico M Goodsaid
  • Nikki Gillum Posnack
  • Zaruhi Karabekian
  • Luther Swift
  • Ara Arutunyan
  • Nikki Gillum
  • Luther M Swift
  • Hao Ding
  • Rafael Jaimes
  • Nikki G Posnack
  • Valentin Krinsky
  • Alain Pumir
  • Karina Bakunts
  • Konstantin Agladze
  • Gulnaz Stybayeva
  • Sana Idrees
  • Rabia Idrees
  • Aria Jamshidi
  • Rafael Jaimes Iii
  • Akhil Chandra
  • Daina Brooks
  • Marco Mercader
  • Daniel A B Gil
  • Ronald Brown
  • Elissa W P Wong
  • Ronald P Brown
  • Nikki D Gillum
  • Brian Martell
  • Vishal Khatri
  • Jane McHowat

Detail Information

Publications22

  1. pmc Interaction between spiral and paced waves in cardiac tissue
    Konstantin Agladze
    Pharmacology and Physiology Department, The George Washington University, 2300 Eye Street, Washington, DC 20037
    Am J Physiol Heart Circ Physiol 293:H503-13. 2007
    ..The data were complemented by numerical simulations, which was used to further analyze experimentally observed behavior...
  2. pmc Phthalate exposure changes the metabolic profile of cardiac muscle cells
    Nikki Gillum Posnack
    Department of Pharmacology and Physiology, The George Washington University, Washington, DC, USA
    Environ Health Perspect 120:1243-51. 2012
    ..They can also act as endocrine-disrupting chemicals and have been linked to the rise in metabolic disorders. However, the effect of phthalates on cardiac metabolism remains largely unknown...
  3. pmc Clinically relevant concentrations of di (2-ethylhexyl) phthalate (DEHP) uncouple cardiac syncytium
    Nikki Gillum
    Pharmacology and Physiology Department, The George Washington University, 2300 Eye Street, Washington, DC 20037, USA
    Toxicol Appl Pharmacol 236:25-38. 2009
    ..The data indicate that DEHP, in clinically relevant concentrations, can impair the electrical and mechanical behavior of a cardiac cell network. Applicability of these findings to human patients remains to be established...
  4. pmc Adhesion proteins, stem cells, and arrhythmogenesis
    Nikki Gillum
    Pharmacology and Physiology Department, The George Washington University, 2300 Eye Street, Washington, DC 20037, USA
    Cardiovasc Toxicol 8:1-13. 2008
    ..We conclude with a brief discussion of how the modulation of cell adhesion via modification of coupling proteins within transplanted cells may facilitate engraftment and alleviate the arrhythmogenic potential of cardiac grafts...
  5. pmc Preprocessing of fluoresced transmembrane potential signals for cardiac optical mapping
    Huda Asfour
    The George Washington University, Washington, DC 20052, USA
    Conf Proc IEEE Eng Med Biol Soc 2011:227-30. 2011
    ....
  6. pmc Immunological barriers to stem-cell based cardiac repair
    Zaruhi Karabekian
    Pharmacology and Physiology Department, The George Washington University, 2300 Eye Street, Washington, DC 20037, USA
    Stem Cell Rev 7:315-25. 2011
    ..Overall, this approach facilitates the development of universal donor stem cells suitable for the regeneration of many different tissue types...
  7. doi request reprint Development of an undergraduate pharmacogenomics curriculum
    Travis J O'Brien
    The George Washington University Medical Center, Ross Hall Room 660A, 2300 Eye Street, NW, Washington, DC 20037, USA
    Pharmacogenomics 10:1979-86. 2009
    ..This course offers the advantage of exposing students to the concepts of pharmacogenomics prior to their enrollment in PhD, PharmD or MD/DO graduate programs...
  8. pmc Exposure to phthalates affects calcium handling and intercellular connectivity of human stem cell-derived cardiomyocytes
    Nikki Gillum Posnack
    Department of Pharmacology and Physiology, The George Washington University, Washington, DC, United States of America
    PLoS ONE 10:e0121927. 2015
    ..Yet, there is little direct evidence linking phthalate exposure to adverse effects in human cells, including cardiomyocytes...
  9. pmc Physiological response of cardiac tissue to bisphenol A: alterations in ventricular pressure and contractility
    Nikki Gillum Posnack
    Department of Pharmacology and Physiology, School of Medicine and Health Sciences, The George Washington University, Washington, District of Columbia and
    Am J Physiol Heart Circ Physiol 309:H267-75. 2015
    ..In conclusion, BPA exposure significantly impaired cardiac performance in a dose-dependent manner, having a major negative impact upon electrical conduction, intracellular Ca(2+) handing, and ventricular contractility. ..
  10. pmc Properties of blebbistatin for cardiac optical mapping and other imaging applications
    Luther M Swift
    Department of Pharmacology and Physiology, The George Washington University Medical Center, 2300 Eye Street, Washington, DC 20037, USA
    Pflugers Arch 464:503-12. 2012
    ..Our findings provide important new information about the properties of this myosin II inhibitor, which will aid in the proper design and interpretation of studies that use this compound...
  11. pmc Gene expression profiling of DEHP-treated cardiomyocytes reveals potential causes of phthalate arrhythmogenicity
    Nikki Gillum Posnack
    The Pharmacology and Physiology Department, The George Washington University, 2300 Eye Street, Washington, DC 20037, USA
    Toxicology 279:54-64. 2011
    ..We have recently reported that clinically relevant concentrations of DEHP can affect electrical coupling between cardiac myocytes causing significant rhythm disturbances. The underlying causes for this effect are currently unknown...
  12. pmc Signal decomposition of transmembrane voltage-sensitive dye fluorescence using a multiresolution wavelet analysis
    Huda Asfour
    Department of Electrical and Computer Engineering, The George Washington University, Washington, DC 20052, USA
    IEEE Trans Biomed Eng 58:2083-93. 2011
    ..It is a promising approach for studying wavefronts without aggressive mechanical tissue constraint or electromechanical uncoupling agents and is, useful for single-camera systems that do not provide for ratiometric imaging...
  13. doi request reprint Downregulation of beta-microglobulin to diminish T-lymphocyte lysis of non-syngeneic cell sources of engineered heart tissue constructs
    Zaruhi Karabekian
    Pharmacology and Physiology Department, The George Washington University, School of Medicine and Health Sciences, 2300 Eye Street, Washington DC 20037, USA
    Biomed Mater 10:034101. 2015
    ..Use of shRNA against beta-2-microglobulin offers a simple and effective approach to minimize immunogenicity of the main cellular components of cardiac tissue constructs in non-syngeneic recipients...
  14. pmc Visualization of epicardial cryoablation lesions using endogenous tissue fluorescence
    Luther Swift
    From the Department of Pharmacology and Physiology, George Washington University School of Medicine and Health Sciences, Washington, DC L S, D A B G, M K, N S Department of Electrical and Computer Engineering, George Washington School of Engineering and Applied Science, Washington, DC D A B G, R J, M K and Division of Cardiology, George Washington University School of Medicine and Health Sciences and Medical Faculty Associates, Washington, DC M M
    Circ Arrhythm Electrophysiol 7:929-37. 2014
    ..We seek to develop an approach that will enable real-time visualization of tissue necrosis during cryo- or radiofrequency ablation procedures...
  15. pmc Formation of cardiac fibers in Matrigel matrix
    Karina Bakunts
    Pharmacology and Physiology Department, The George Washington University, Washington, DC 20037, USA
    Biotechniques 44:341-8. 2008
    ..The described approach allows continuous structural and functional monitoring of 20-300-micron-thick cardiac fibers and provides easy access to epitopes for immunostaining purposes...
  16. pmc Effects of N-cadherin overexpression on the adhesion properties of embryonic stem cells
    Zaruhi Karabekian
    Pharmacology and Physiology Department, The George Washington University, Washington, DC 20037, USA
    Cell Adh Migr 3:305-10. 2009
    ..The findings suggest that N-cadherin overexpression can facilitate electromechanical integration of stem cells into excitable tissues with endogenously high levels of N-cadherin, such as the heart and brain...
  17. pmc Locations of ectopic beats coincide with spatial gradients of NADH in a regional model of low-flow reperfusion
    Matthew Kay
    Department of Pharmacology and Physiology, George Washington University, 2300 Eye Street NW, Washington, DC 20037, USA
    Am J Physiol Heart Circ Physiol 294:H2400-5. 2008
    ..The origins of ectopic beats were traceable to areas of high spatial gradients of changes in NADH fluorescence caused by low-flow reperfusion...
  18. pmc Controlled regional hypoperfusion in Langendorff heart preparations
    Luther Swift
    Department of Pharmacology, The George Washington University, Washington, DC 20052, USA
    Physiol Meas 29:269-79. 2008
    ....
  19. pmc Genesis of ectopic waves: role of coupling, automaticity, and heterogeneity
    Alain Pumir
    Institut Non Lineaire de Nice, Valbonne, France
    Biophys J 89:2332-49. 2005
    ..These studies add to the understanding of initiation and progression of arrhythmias and can be applied to other phenomena that deal with assemblies of coupled oscillators...
  20. pmc Multiple injury approach and its use for toxicity studies
    Ara Arutunyan
    Department of Physiology, Texas Tech University Health Sciences Center, Lubbock, TX 79430, USA
    Cardiovasc Toxicol 4:1-10. 2004
    ..These possibilities are illustrated in cultures of neonatal rat cardiomyocytes using oxidant- and calcium-sensitive fluorescent indicators...
  21. ncbi request reprint Inhibition of membrane-associated calcium-independent phospholipase A2 as a potential culprit of anthracycline cardiotoxicity
    Luther Swift
    Department of Physiology, Texas Tech University Health Sciences Center, Lubbock, Texas 79430, USA
    Cancer Res 63:5992-8. 2003
    ..The results suggest that iPLA(2) inhibition may be the initial step in a chain of events leading to chronic cardiotoxicity of the anthracyclines...
  22. pmc Behavior of ectopic surface: effects of beta-adrenergic stimulation and uncoupling
    Ara Arutunyan
    Physiology Department, Texas Tech University Health Sciences Center, 3601 4th St, Lubbock TX 79430, USA
    Am J Physiol Heart Circ Physiol 285:H2531-42. 2003
    ..This transient condition appears to serve as an essential step for the ectopic activity to "mature" before escaping into the surrounding control network...