Bruno Sainz

Summary

Affiliation: The Scripps Research Institute
Country: USA

Publications

  1. pmc Synergistic inhibition of human cytomegalovirus replication by interferon-alpha/beta and interferon-gamma
    Bruno Sainz
    Department of Microbiology and Immunology, Program in Molecular Pathogenesis and Immunity, Tulane University Health Sciences Center, 1430 Tulane Avenue, SL 38, New Orleans, LA 70112, USA
    Virol J 2:14. 2005
  2. pmc Inhibition of severe acute respiratory syndrome-associated coronavirus (SARS-CoV) infectivity by peptides analogous to the viral spike protein
    Bruno Sainz
    Department of Microbiology and Immunology, Tulane University Health Sciences Center, New Orleans, LA 70112, USA
    Virus Res 120:146-55. 2006
  3. pmc Identification and characterization of the putative fusion peptide of the severe acute respiratory syndrome-associated coronavirus spike protein
    Bruno Sainz
    Department of Microbiology and Immunology, Tulane University Health Sciences Center, 1430 Tulane Avenue, SL 43, New Orleans, LA 70112, USA
    J Virol 79:7195-206. 2005
  4. ncbi request reprint Interferon-beta and interferon-gamma synergistically inhibit the replication of severe acute respiratory syndrome-associated coronavirus (SARS-CoV)
    Bruno Sainz
    Department of Microbiology and Immunology, Program in Molecular Pathogenesis and Immunity, Tulane University Health Sciences Center, New Orleans, LA 70112, USA
    Virology 329:11-7. 2004
  5. pmc Alpha/Beta interferon and gamma interferon synergize to inhibit the replication of herpes simplex virus type 1
    Bruno Sainz
    Department of Microbiology and Immunology, Tulane University Health Sciences Center, Program in Molecular Pathogenesis and Immunity, New Orleans, Louisiana 70112, USA
    J Virol 76:11541-50. 2002
  6. pmc Permissive human cytomegalovirus infection of a first trimester extravillous cytotrophoblast cell line
    Heather L LaMarca
    Interdisciplinary Program in Molecular and Cellular Biology, Tulane University Health Sciences Center, New Orleans, LA, USA
    Virol J 1:8. 2004
  7. ncbi request reprint The aromatic domain of the coronavirus class I viral fusion protein induces membrane permeabilization: putative role during viral entry
    Bruno Sainz
    Department of Microbiology and Immunology, Program in Molecular Pathogenesis and Immunity, Tulane University Health Sciences Center, New Orleans, Louisiana 70112, USA
    Biochemistry 44:947-58. 2005
  8. ncbi request reprint Anti-20S proteasome antibodies in psoriatic arthritis
    Ines Colmegna
    Section of Rheumatology, Department of Medicine, Louisiana State University Health Sciences Center, New Orleans, USA
    J Rheumatol 35:674-6. 2008
  9. ncbi request reprint Synergistic inhibition of SARS-coronavirus replication by type I and type II IFN
    Eric C Mossel
    Colorado State University, Fort Collins 80523, USA
    Adv Exp Med Biol 581:503-6. 2006
  10. pmc Production of infectious hepatitis C virus by well-differentiated, growth-arrested human hepatoma-derived cells
    Bruno Sainz
    Department of Molecular and Experimental Medicine, The Scripps Research Institute, 10550 North Torrey Pines Road, SBR 10, La Jolla, CA 92037, USA
    J Virol 80:10253-7. 2006

Research Grants

  1. MINORITY PREDOCTORAL FELLOWSHIP PROGRAM
    Bruno Sainz; Fiscal Year: 2004

Collaborators

Detail Information

Publications11

  1. pmc Synergistic inhibition of human cytomegalovirus replication by interferon-alpha/beta and interferon-gamma
    Bruno Sainz
    Department of Microbiology and Immunology, Program in Molecular Pathogenesis and Immunity, Tulane University Health Sciences Center, 1430 Tulane Avenue, SL 38, New Orleans, LA 70112, USA
    Virol J 2:14. 2005
    ..To determine whether this phenomenon is shared by other herpesviruses, we investigated the effects of IFNs on human cytomegalovirus (HCMV) replication...
  2. pmc Inhibition of severe acute respiratory syndrome-associated coronavirus (SARS-CoV) infectivity by peptides analogous to the viral spike protein
    Bruno Sainz
    Department of Microbiology and Immunology, Tulane University Health Sciences Center, New Orleans, LA 70112, USA
    Virus Res 120:146-55. 2006
    ..The antiviral activity of the CoV peptides tested provides an attractive basis for the development of new fusion peptide inhibitors corresponding to regions outside the fusion protein heptad repeat regions...
  3. pmc Identification and characterization of the putative fusion peptide of the severe acute respiratory syndrome-associated coronavirus spike protein
    Bruno Sainz
    Department of Microbiology and Immunology, Tulane University Health Sciences Center, 1430 Tulane Avenue, SL 43, New Orleans, LA 70112, USA
    J Virol 79:7195-206. 2005
    ..Based on the activity of SARS(WW-I), we propose that the hydrophobic stretch of 19 aa corresponding to residues 770 to 788 is a fusion peptide of the SARS-CoV S2 subunit...
  4. ncbi request reprint Interferon-beta and interferon-gamma synergistically inhibit the replication of severe acute respiratory syndrome-associated coronavirus (SARS-CoV)
    Bruno Sainz
    Department of Microbiology and Immunology, Program in Molecular Pathogenesis and Immunity, Tulane University Health Sciences Center, New Orleans, LA 70112, USA
    Virology 329:11-7. 2004
    ..These studies suggest that combination IFN treatment warrants further investigation as a treatment for SARS...
  5. pmc Alpha/Beta interferon and gamma interferon synergize to inhibit the replication of herpes simplex virus type 1
    Bruno Sainz
    Department of Microbiology and Immunology, Tulane University Health Sciences Center, Program in Molecular Pathogenesis and Immunity, New Orleans, Louisiana 70112, USA
    J Virol 76:11541-50. 2002
    ..Because IFN-alpha or IFN-beta is produced by most cells as an innate response to virus infection, the results imply that IFN-gamma secreted by T cells may provide a critical second signal that potently inhibits HSV-1 replication in vivo...
  6. pmc Permissive human cytomegalovirus infection of a first trimester extravillous cytotrophoblast cell line
    Heather L LaMarca
    Interdisciplinary Program in Molecular and Cellular Biology, Tulane University Health Sciences Center, New Orleans, LA, USA
    Virol J 1:8. 2004
    ..Our findings suggest that these cells may serve as useful tools for future mechanistic studies of HCMV pathogenesis during early pregnancy...
  7. ncbi request reprint The aromatic domain of the coronavirus class I viral fusion protein induces membrane permeabilization: putative role during viral entry
    Bruno Sainz
    Department of Microbiology and Immunology, Program in Molecular Pathogenesis and Immunity, Tulane University Health Sciences Center, New Orleans, Louisiana 70112, USA
    Biochemistry 44:947-58. 2005
    ....
  8. ncbi request reprint Anti-20S proteasome antibodies in psoriatic arthritis
    Ines Colmegna
    Section of Rheumatology, Department of Medicine, Louisiana State University Health Sciences Center, New Orleans, USA
    J Rheumatol 35:674-6. 2008
    ....
  9. ncbi request reprint Synergistic inhibition of SARS-coronavirus replication by type I and type II IFN
    Eric C Mossel
    Colorado State University, Fort Collins 80523, USA
    Adv Exp Med Biol 581:503-6. 2006
  10. pmc Production of infectious hepatitis C virus by well-differentiated, growth-arrested human hepatoma-derived cells
    Bruno Sainz
    Department of Molecular and Experimental Medicine, The Scripps Research Institute, 10550 North Torrey Pines Road, SBR 10, La Jolla, CA 92037, USA
    J Virol 80:10253-7. 2006
    ....
  11. ncbi request reprint The immediate-early protein, ICP0, is essential for the resistance of herpes simplex virus to interferon-alpha/beta
    Peter Härle
    Department of Ophthalmology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma 73104, USA
    Virology 293:295-304. 2002
    ..This concept is discussed in light of its potential relevance to the establishment of latent HSV-1 infections...

Research Grants1

  1. MINORITY PREDOCTORAL FELLOWSHIP PROGRAM
    Bruno Sainz; Fiscal Year: 2004
    ..The goal of the studies proposed herein is to elucidate the mechanism(s) by which IFN-beta and IFN-gamma inhibit HSV-1 replication and to identify the cellular factors that are involved in this process. ..