Affiliation: The Ohio State University
- Resistance against syncytium-inducing human immunodeficiency virus type 1 (HIV-1) in selected CD4(+) T cells from an HIV-1-infected nonprogressor: evidence of a novel pathway of resistance mediated by a soluble factor(s) that acts after virus entryK Saha
Departments of Pediatrics, Molecular Virology, Immunology, and Medical Genetics, Division of Molecular Medicine, Children s Hospital Research Foundation, The Ohio State University, Columbus, Ohio 43205, USA
J Virol 73:7891-8. 1999..Our results also suggest a novel mechanism of inhibition of SI viruses that acts at a stage after virus entry...
- Isolation of primary HIV-1 that target CD8+ T lymphocytes using CD8 as a receptorK Saha
Division of Molecular Medicine, Department of Pediatrics, Children s Research Institute and The Ohio State University Medical Center, Columbus, Ohio 43205, USA
Nat Med 7:65-72. 2001..Novel changes were observed in envelope sequences of CD8-tropic viruses. These results provide initial evidence that HIV-1 can mutate to infect CD8+ cells using CD8 as a receptor...
- Evidence of productively infected CD8+ T cells in patients with AIDS: implications for HIV-1 pathogenesisK Saha
Children s Research Institute, Department of Pediatrics and Molecular Virology, Immunology, and Medical Genetics, The Ohio State University Medical Center, Columbus, Ohio 43205 2696, USA
J Acquir Immune Defic Syndr 26:199-207. 2001..Direct infection of CD8+ T lymphocytes may play a role in the eventual failure of these cells in HIV-1 infection...
- Infection of human and non-human cells by a highly fusogenic primary CD4-independent HIV-1 isolate with a truncated envelope cytoplasmic tailKunal Saha
Department of Pediatrics and Molecular Virology, Immunology and Medical Genetics, Children s Research Institute and Ohio State University Medical Center, Columbus, 43205, USA
Virology 337:30-44. 2005..In vivo evolution of similar HIV-1 mutants may have important implications in AIDS pathogenesis...
- CXCR4-dependent infection of CD8+, but not CD4+, lymphocytes by a primary human immunodeficiency virus type 1 isolateBouchra Zerhouni
Department of Pediatrics, Children s Research Institute, Ohio State University Medical Center, 700 Children s Drive, Room W532, Columbus, OH 43205, USA
J Virol 78:12288-96. 2004..Finally, our findings suggest that a more careful evaluation is necessary before the random use of AMD3100 as a new entry inhibitor in patients harboring SI HIV-1 strains...
- Isolation of CD4-independent primary human immunodeficiency virus type 1 isolates that are syncytium inducing and acutely cytopathic for CD8+ lymphocytesBouchra Zerhouni
Children s Research Institute, Children s Hospital, Department of Molecular Virology, The Ohio State University Medical Center, Columbus, Ohio, USA
J Virol 78:1243-55. 2004..In addition, this study also provides evidence of primary HIV-1 variants that are syncytium inducing and acutely cytopathic for CD8(+) lymphocytes...