S A Saghir

Summary

Affiliation: The Dow Chemical Company
Country: USA

Publications

  1. pmc Low-dose pharmacokinetics and oral bioavailability of dichloroacetate in naive and GST-zeta-depleted rats
    Shakil A Saghir
    Battelle Pacific Northwest National Laboratory, Richland, Washington, USA
    Environ Health Perspect 110:757-63. 2002
  2. ncbi Strategies to assess systemic exposure of chemicals in subchronic/chronic diet and drinking water studies
    Shakil A Saghir
    Toxicology and Environmental Research and Consulting, The Dow Chemical Company, 1803 Building, Midland, MI 48674, USA
    Toxicol Appl Pharmacol 211:245-60. 2006
  3. ncbi Effects of black carbon and montmorillonite clay on multiphasic hexachlorobenzene desorption from sediments
    Yunzhou Chai
    Toxicology and Environmental Research and Consulting, The Dow Chemical Company, 1803 Building, Midland, MI 48674, United States
    Chemosphere 69:1204-12. 2007
  4. doi Assessment of diurnal systemic dose of agrochemicals in regulatory toxicity testing--an integrated approach without additional animal use
    Shakil A Saghir
    The Dow Chemical Company, Toxicology and Environmental Research and Consulting, Midland, MI 48674, USA
    Regul Toxicol Pharmacol 63:321-32. 2012
  5. doi Role of iodine in diiodomethyl-p-tolylsulfone induced reproductive toxicity in rats: proposed mode of action
    Shakil A Saghir
    Toxicology and Environmental Research and Consulting, The Dow Chemical Company, 1803 Building, Midland, MI 48674, USA
    Regul Toxicol Pharmacol 62:496-503. 2012
  6. doi Role of iodine in the toxicity of diiodomethyl-p-tolylsulfone (DIMPTS) in rats: ADME
    Shakil A Saghir
    Toxicology and Environmental Research and Consulting, The Dow Chemical Company, 1803 Building, Midland, MI 48674, USA
    Regul Toxicol Pharmacol 62:482-95. 2012
  7. ncbi Pharmacokinetics of aminomethylpropanol in rats following oral and a novel dermal study design
    Shakil A Saghir
    Toxicology and Environmental Research and Consulting, The Dow Chemical Company, 1803 Building, Midland, MI 48674, United States
    Food Chem Toxicol 46:678-87. 2008
  8. doi Mechanism of trifluralin-induced thyroid tumors in rats
    Shakil A Saghir
    Toxicology and Environmental Research and Consulting, The Dow Chemical Company, Midland, MI 48674, USA
    Toxicol Lett 180:38-45. 2008
  9. doi Simulation of repeated dose kinetics of methyl isobutyl ketone in humans from experimental single-dose inhalation exposure
    Shakil A Saghir
    Toxicology and Environmental Research and Consulting, The Dow Chemical Company, 1803 Building, Midland, MI 48674, USA
    Regul Toxicol Pharmacol 52:180-8. 2008
  10. doi Mechanism of ethylbenzene-induced mouse-specific lung tumor: metabolism of ethylbenzene by rat, mouse, and human liver and lung microsomes
    Shakil A Saghir
    Toxicology and Environmental Research and Consulting, The Dow Chemical Company, Midland, Michigan 48674, USA
    Toxicol Sci 107:352-66. 2009

Detail Information

Publications24

  1. pmc Low-dose pharmacokinetics and oral bioavailability of dichloroacetate in naive and GST-zeta-depleted rats
    Shakil A Saghir
    Battelle Pacific Northwest National Laboratory, Richland, Washington, USA
    Environ Health Perspect 110:757-63. 2002
    ....
  2. ncbi Strategies to assess systemic exposure of chemicals in subchronic/chronic diet and drinking water studies
    Shakil A Saghir
    Toxicology and Environmental Research and Consulting, The Dow Chemical Company, 1803 Building, Midland, MI 48674, USA
    Toxicol Appl Pharmacol 211:245-60. 2006
    ..Determining these parameters in the early stages of testing will provide critical information to improve the appropriate design of other longer-term toxicity studies...
  3. ncbi Effects of black carbon and montmorillonite clay on multiphasic hexachlorobenzene desorption from sediments
    Yunzhou Chai
    Toxicology and Environmental Research and Consulting, The Dow Chemical Company, 1803 Building, Midland, MI 48674, United States
    Chemosphere 69:1204-12. 2007
    ....
  4. doi Assessment of diurnal systemic dose of agrochemicals in regulatory toxicity testing--an integrated approach without additional animal use
    Shakil A Saghir
    The Dow Chemical Company, Toxicology and Environmental Research and Consulting, Midland, MI 48674, USA
    Regul Toxicol Pharmacol 63:321-32. 2012
    ..Such data should also be useful in mode of action studies and to improve human risk assessments...
  5. doi Role of iodine in diiodomethyl-p-tolylsulfone induced reproductive toxicity in rats: proposed mode of action
    Shakil A Saghir
    Toxicology and Environmental Research and Consulting, The Dow Chemical Company, 1803 Building, Midland, MI 48674, USA
    Regul Toxicol Pharmacol 62:496-503. 2012
    ..These data support the hypothesis that the dystocia, altered neonatal survival and hypothyroidism following repeated dietary administration of DIMPTS were due to excessive iodine released from DIMPTS during absorption and metabolism...
  6. doi Role of iodine in the toxicity of diiodomethyl-p-tolylsulfone (DIMPTS) in rats: ADME
    Shakil A Saghir
    Toxicology and Environmental Research and Consulting, The Dow Chemical Company, 1803 Building, Midland, MI 48674, USA
    Regul Toxicol Pharmacol 62:482-95. 2012
    ..These data show that the liberated iodide is the ultimate toxicant of DIMPTS, which is readily transported to pups through milk, while the methyltolylsulfone backbone structure (MPTS) of DIMPTS is relatively nontoxic...
  7. ncbi Pharmacokinetics of aminomethylpropanol in rats following oral and a novel dermal study design
    Shakil A Saghir
    Toxicology and Environmental Research and Consulting, The Dow Chemical Company, 1803 Building, Midland, MI 48674, United States
    Food Chem Toxicol 46:678-87. 2008
    ..Additionally, systemically absorbed dose will be rapidly eliminated from the body with little remaining at the application site...
  8. doi Mechanism of trifluralin-induced thyroid tumors in rats
    Shakil A Saghir
    Toxicology and Environmental Research and Consulting, The Dow Chemical Company, Midland, MI 48674, USA
    Toxicol Lett 180:38-45. 2008
    ....
  9. doi Simulation of repeated dose kinetics of methyl isobutyl ketone in humans from experimental single-dose inhalation exposure
    Shakil A Saghir
    Toxicology and Environmental Research and Consulting, The Dow Chemical Company, 1803 Building, Midland, MI 48674, USA
    Regul Toxicol Pharmacol 52:180-8. 2008
    ..On the basis of these results, it is concluded that accumulation of MIBK in workers due to repeated inhalation exposure is not likely to occur at the current TLV-TWA concentration of 50 ppm...
  10. doi Mechanism of ethylbenzene-induced mouse-specific lung tumor: metabolism of ethylbenzene by rat, mouse, and human liver and lung microsomes
    Shakil A Saghir
    Toxicology and Environmental Research and Consulting, The Dow Chemical Company, Midland, Michigan 48674, USA
    Toxicol Sci 107:352-66. 2009
    ....
  11. doi In vitro metabolism and covalent binding of ethylbenzene to microsomal protein as a possible mechanism of ethylbenzene-induced mouse lung tumorigenesis
    Shakil A Saghir
    Toxicology and Environmental Research and Consulting, The Dow Chemical Company, Midland, MI 48674, USA
    Regul Toxicol Pharmacol 57:129-35. 2010
    ..In contrast, CYP2E1 appears to be the primary CYP isozyme responsible for the reactive metabolites of EB in the liver...
  12. doi Dermal penetration of ethylene glycol through human skin in vitro
    Shakil A Saghir
    Toxicology and Environmental Research and Consulting, The Dow Chemical Company, Midland, MI 48674, USA
    Int J Toxicol 29:268-76. 2010
    ..5 x 10(-4) and 2.6 x 10(-4) cm/h. These findings demonstrate that EG dermal penetration is expected to be very low and to be slow, indicating very limited systemic or internal dose of EG due to dermal exposure...
  13. doi Kinetics of trihalogenated acetic acid metabolism and isoform specificity in liver microsomes
    Shakil A Saghir
    Toxicology and Environmental Research and Consulting, The Dow Chemical Company, Midland, MI 48674, USA
    Int J Toxicol 30:551-61. 2011
    ....
  14. ncbi Effect of organic carbon content, clay type, and aging on the oral bioavailability of hexachlorobenzene in rats
    Shakil A Saghir
    Toxicology and Environmental Research and Consulting, The Dow Chemical Company, Midland, Michigan 48674, USA
    Environ Toxicol Chem 26:2420-9. 2007
    ..Increase in the fecal elimination and decrease in oral bioavailability of (14)C-HCB was related to the increase in clay and black carbon...
  15. ncbi Oral absorption, metabolism and excretion of 1-phenoxy-2-propanol in rats
    S A Saghir
    Toxicology and Environmental Research and Consulting, The Dow Chemical Company, Midland, MI 48674, USA
    Xenobiotica 33:1059-71. 2003
    ..4. Rapid oral absorption, metabolism and urinary excretion of 1-phenoxy-2-propanol in rats were similar to other propylene glycol ethers...
  16. ncbi Investigation of the formation of N-nitrosodiethanolamine in B6C3F1 mice following topical administration of triethanolamine
    Shakil A Saghir
    Toxicology and Environmental Research and Consulting, The Dow Chemical Company, Midland, MI 48642, USA
    Regul Toxicol Pharmacol 43:10-8. 2005
    ..Levels of NDELA measured in blood and ingesta after a single oral dose of TEA and NaNO(2) were less than those in DEA controls. These findings in toto confirm the lack of any significant formation of NDELA from TEA in vivo...
  17. ncbi Pharmacokinetics and bioavailability of diisopropanolamine (DIPA) in rats following intravenous or dermal application
    S A Saghir
    Toxicology and Environmental Research and Consulting, The Dow Chemical Company, Bldg 1803, Midland, MI 48674, United States
    Food Chem Toxicol 45:2047-56. 2007
    ....
  18. ncbi Validation of Haber's Rule (dose x time = constant) in rats and mice for monochloroacetic acid and 2,3,7,8-tetrachlorodibenzo-p-dioxin under conditions of kinetic steady state
    Shakil A Saghir
    Department of Pharmacology, Toxicology, and Therapeutics, University of Kansas Medical Center, 3901 Rainbow Blvd, Mail Stop 1018, Kansas City, KS 66160 7417, USA
    Toxicology 215:48-56. 2005
    ....
  19. ncbi Kinetics of monochloroacetic acid in adult male rats after intravenous injection of a subtoxic and a toxic dose
    S A Saghir
    Department of Pharmacology, Toxicology, and Therapeutics, University of Kansas Medical Center, Kansas City, Kansas 66160, USA
    J Pharmacol Exp Ther 296:612-22. 2001
    ..The rate-determining step in the toxicity of MCA was identified as its detoxification by the liver. A therapeutic approach in MCA intoxications is suggested...
  20. doi Effects of aging and sediment composition on hexachlorobenzene desorption resistance compared to oral bioavailability in rats
    Yunzhou Chai
    Toxicology and Environmental Research and Consulting, The Dow Chemical Company, 1803 Building, Midland, MI 48674, United States
    Chemosphere 72:432-41. 2008
    ..These results showed that montmorillonite clay, black carbon and aging reduced physicochemical availability and ultimately bioavailability of sediment-bound HCB...
  21. ncbi Kinetics of monochloroacetic acid at subtoxic and toxic doses in rats after single oral and dermal administrations
    Shakil A Saghir
    Department of Pharmacology, Toxicology, and Therapeutics, University of Kansas Medical Center, 3901 Rainbow Boulevard, Kansas City, Kansas 66160, USA
    Toxicol Sci 76:51-64. 2003
    ....
  22. ncbi Preparation, characterization, and scale-up of ketoconazole with enhanced dissolution and bioavailability
    Edmund J Elder
    Dowpharma, The Dow Chemical Company, Midland, Michigan, USA
    Drug Dev Ind Pharm 33:755-65. 2007
    ....
  23. ncbi Toxicokinetics and oral bioavailability of halogenated acetic acids mixtures in naïve and GSTzeta-depleted rats
    Shakil A Saghir
    Battelle Pacific Northwest National Laboratory, Sequim, Washington 98352, USA
    Toxicol Sci 84:214-24. 2005
    ..When considering HAA dosimetry, importance should be placed on both the components of the mixture and prior exposure history to di-HAAs...
  24. doi Physiologically based pharmacokinetic model development and simulations for ethylene dichloride (1,2-dichloroethane) in rats
    Lisa M Sweeney
    The Sapphire Group, Dayton Office, 2661 Commons Boulevard, Suite 240, 2nd Floor, Dayton, OH 45431, USA
    Regul Toxicol Pharmacol 51:311-23. 2008
    ....