A Safdar

Summary

Affiliation: The University of Texas
Country: USA

Publications

  1. ncbi Changing trends in etiology of bacteremia in patients with cancer
    A Safdar
    Department of Infectious Diseases, Infection Control, and Employee Health, Unit 402, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
    Eur J Clin Microbiol Infect Dis 25:522-6. 2006
  2. doi Multiple-dose granulocyte-macrophage-colony-stimulating factor plus 23-valent polysaccharide pneumococcal vaccine in patients with chronic lymphocytic leukemia: a prospective, randomized trial of safety and immunogenicity
    Amar Safdar
    Department of Infectious Diseases, Infection Control, and Employee Health, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Cancer 113:383-7. 2008
  3. ncbi Curvularia--favorable response to oral itraconazole therapy in two patients with locally invasive phaeohyphomycosis
    A Safdar
    Department of Infectious Diseases, Infection Control and Employee Health, 402, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, Texas 77030 4095, USA
    Clin Microbiol Infect 9:1219-23. 2003
  4. ncbi Strongyloidiasis in patients at a comprehensive cancer center in the United States
    Amar Safdar
    Department of Infectious Diseases, Infection Control, and Employee Health, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Cancer 100:1531-6. 2004
  5. doi Immune modulatory activity of ribavirin for serious human metapneumovirus disease: early i.v. therapy may improve outcomes in immunosuppressed SCT recipients
    A Safdar
    Department of Infectious Diseases, Infection Control and Employee Health, MD Anderson Cancer Center, Houston, TX, USA
    Bone Marrow Transplant 41:707-8. 2008
  6. ncbi Clinical significance of non-Candida fungal blood isolation in patients undergoing high-risk allogeneic hematopoietic stem cell transplantation (1993-2001)
    Amar Safdar
    Division of Infectious Diseases, Department of Internal Medicine, University of South Carolina School of Medicine, Columbia, South Carolina, USA
    Cancer 100:2456-61. 2004
  7. doi Stenotrophomonas maltophilia: changing spectrum of a serious bacterial pathogen in patients with cancer
    Amar Safdar
    Dept of Infectious Diseases, Infection Control, and Employee Health, 402, The M D Anderson Cancer Center, University of Texas, 1515 Holcombe Blvd, Houston, TX 77030, USA
    Clin Infect Dis 45:1602-9. 2007
  8. ncbi Difficulties with fungal infections in acute myelogenous leukemia patients: immune enhancement strategies
    Amar Safdar
    Department of Infectious Diseases, Infection Control, and Employee Health, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Oncologist 12:2-6. 2007
  9. ncbi The safety of interferon-gamma-1b therapy for invasive fungal infections after hematopoietic stem cell transplantation
    Amar Safdar
    Department of Infectious Diseases, Infection Control, and Employee Health, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Cancer 103:731-9. 2005
  10. ncbi Mycobacterium lentiflavum, a recently identified slow-growing mycobacterial species: clinical significance in immunosuppressed cancer patients and summary of reported cases of infection
    A Safdar
    Department of Infectious Diseases, Infection Control and Employee Health, Division of Internal Medicine, Unit 402, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030 4095, USA
    Eur J Clin Microbiol Infect Dis 24:554-8. 2005

Detail Information

Publications79

  1. ncbi Changing trends in etiology of bacteremia in patients with cancer
    A Safdar
    Department of Infectious Diseases, Infection Control, and Employee Health, Unit 402, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
    Eur J Clin Microbiol Infect Dis 25:522-6. 2006
    ..5). The spectrum of BSI continues to change and its prognostic implications in cancer patients needs further study...
  2. doi Multiple-dose granulocyte-macrophage-colony-stimulating factor plus 23-valent polysaccharide pneumococcal vaccine in patients with chronic lymphocytic leukemia: a prospective, randomized trial of safety and immunogenicity
    Amar Safdar
    Department of Infectious Diseases, Infection Control, and Employee Health, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Cancer 113:383-7. 2008
    ....
  3. ncbi Curvularia--favorable response to oral itraconazole therapy in two patients with locally invasive phaeohyphomycosis
    A Safdar
    Department of Infectious Diseases, Infection Control and Employee Health, 402, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, Texas 77030 4095, USA
    Clin Microbiol Infect 9:1219-23. 2003
    ..Both patients showed excellent responses to treatment with itraconazole suspension. Oral itraconazole may provide a safe and effective alternative for patients with locally invasive non-disseminated mycoses due to Curvularia species...
  4. ncbi Strongyloidiasis in patients at a comprehensive cancer center in the United States
    Amar Safdar
    Department of Infectious Diseases, Infection Control, and Employee Health, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Cancer 100:1531-6. 2004
    ..The frequency of Strongyloides stercoralis infestation and complication in patients with cancer in the United States is unknown...
  5. doi Immune modulatory activity of ribavirin for serious human metapneumovirus disease: early i.v. therapy may improve outcomes in immunosuppressed SCT recipients
    A Safdar
    Department of Infectious Diseases, Infection Control and Employee Health, MD Anderson Cancer Center, Houston, TX, USA
    Bone Marrow Transplant 41:707-8. 2008
  6. ncbi Clinical significance of non-Candida fungal blood isolation in patients undergoing high-risk allogeneic hematopoietic stem cell transplantation (1993-2001)
    Amar Safdar
    Division of Infectious Diseases, Department of Internal Medicine, University of South Carolina School of Medicine, Columbia, South Carolina, USA
    Cancer 100:2456-61. 2004
    ..The authors hypothesized that isolation of non-Candida fungi from blood cultures in patients undergoing high-risk HSCT would have clinical significance...
  7. doi Stenotrophomonas maltophilia: changing spectrum of a serious bacterial pathogen in patients with cancer
    Amar Safdar
    Dept of Infectious Diseases, Infection Control, and Employee Health, 402, The M D Anderson Cancer Center, University of Texas, 1515 Holcombe Blvd, Houston, TX 77030, USA
    Clin Infect Dis 45:1602-9. 2007
    ..Agents that improve outer-membrane permeability and broad-spectrum beta-lactamase inhibitors may favorably impact difficult-to-treat (i.e., multidrug resistant) S. maltophilia infections...
  8. ncbi Difficulties with fungal infections in acute myelogenous leukemia patients: immune enhancement strategies
    Amar Safdar
    Department of Infectious Diseases, Infection Control, and Employee Health, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Oncologist 12:2-6. 2007
    ..In difficult-to-treat fungal infections, the addition of cytokines appears to improve outcome and may be considered early in severely immunosuppressed patients with AML...
  9. ncbi The safety of interferon-gamma-1b therapy for invasive fungal infections after hematopoietic stem cell transplantation
    Amar Safdar
    Department of Infectious Diseases, Infection Control, and Employee Health, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Cancer 103:731-9. 2005
    ..The authors sought to evaluate the safety of adjuvant recombinant interferon-gamma-1b as an immune-modulatory therapy HSCT recipients...
  10. ncbi Mycobacterium lentiflavum, a recently identified slow-growing mycobacterial species: clinical significance in immunosuppressed cancer patients and summary of reported cases of infection
    A Safdar
    Department of Infectious Diseases, Infection Control and Employee Health, Division of Internal Medicine, Unit 402, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030 4095, USA
    Eur J Clin Microbiol Infect Dis 24:554-8. 2005
    ..M. lentiflavum was not clinically significant, even in these severely immunosuppressed cancer patients...
  11. ncbi Baculovirus-expressed influenza vaccine. A novel technology for safe and expeditious vaccine production for human use
    Amar Safdar
    MD Anderson Cancer Center, Department of Infectious Diseases, Infection Control and Employee Health, Houston, Texas 77030, USA
    Expert Opin Investig Drugs 16:927-34. 2007
    ..In addition, a highly purified recombinant protein vaccine results in an improved influenza vaccine response in those with high-risk medical conditions...
  12. ncbi Vancomycin tolerance, a potential mechanism for refractory gram-positive bacteremia observational study in patients with cancer
    Amar Safdar
    Department of Infectious Diseases, Infection Control, and Employee Health, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Cancer 106:1815-20. 2006
    ..The clinical significance of infections caused by vancomycin-tolerant (Vt) gram-positive organisms in patients with cancer remains unclear...
  13. ncbi High-dose caspofungin combination antifungal therapy in patients with hematologic malignancies and hematopoietic stem cell transplantation
    A Safdar
    Department of Infectious Diseases, Infection Control, and Employee Health, MD Anderson Cancer Center, Houston, TX 77030, USA
    Bone Marrow Transplant 39:157-64. 2007
    ..04) and/or interferon gamma (26 vs 5% in SD group; P=0.003) immune enhancement. Further studies are needed to evaluate efficacy of HD-CAP in severely immunosuppressed cancer patients with invasive fungal infections...
  14. ncbi Dose-related safety and immunogenicity of baculovirus-expressed trivalent influenza vaccine: a double-blind, controlled trial in adult patients with non-Hodgkin B cell lymphoma
    Amar Safdar
    Department of Infectious Diseases, Infection Control, and Employee Health, University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    J Infect Dis 194:1394-7. 2006
    ..For each vaccine, the highest frequencies of increases in neutralizing antibody levels and the highest mean titers occurred in those given the 135- microg vaccine...
  15. ncbi Recombinant interferon gamma1b immune enhancement in 20 patients with hematologic malignancies and systemic opportunistic infections treated with donor granulocyte transfusions
    Amar Safdar
    Department of Infectious Diseases, Infection Control, and Employee Health, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Cancer 106:2664-71. 2006
    ..The authors evaluated the safety and efficacy of immune enhancement using recombinant interferon gamma1b (rIFN-gamma1b) in patients with cancer who received GTX for refractory, systemic, opportunistic infections...
  16. ncbi Strategies to enhance immune function in hematopoietic transplantation recipients who have fungal infections
    A Safdar
    Department of Infectious Diseases, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
    Bone Marrow Transplant 38:327-37. 2006
    ....
  17. ncbi Impact of high-dose granulocyte transfusions in patients with cancer with candidemia: retrospective case-control analysis of 491 episodes of Candida species bloodstream infections
    Amar Safdar
    Department of Infectious Diseases, Infection Control, and Employee Health, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Cancer 101:2859-65. 2004
    ..The authors sought to determine the impact of high-dose (approximately 5.5 x 10(10) cells) GTX in patients with candidemia...
  18. ncbi Listeriosis in patients at a comprehensive cancer center, 1955-1997
    Amar Safdar
    Infectious Diseases Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, and Weill Medical College of Cornell University, New York, New York, USA
    Clin Infect Dis 37:359-64. 2003
    ..The presence of advanced liver disease may have increased the risk of systemic listeriosis in susceptible patients with underlying cancer...
  19. doi Drug-induced nephrotoxicity caused by amphotericin B lipid complex and liposomal amphotericin B: a review and meta-analysis
    Amar Safdar
    Immunology Research Program, Department of Infectious Diseases, Infection Control and Employee Health, The Anderson Cancer Center, Houston, Texas 77030, USA
    Medicine (Baltimore) 89:236-44. 2010
    ..09; n = 839); the 7 remaining studies were more homogenous by Breslow-Day test (p = 0.054). Our results suggest that nephrotoxicity is generally similar for ABLC and L-AmB in patients receiving antifungal therapy and prophylaxis...
  20. doi Infections in non-myeloablative hematopoietic stem cell transplantation patients with lymphoid malignancies: spectrum of infections, predictors of outcome and proposed guidelines for fungal infection prevention
    A Safdar
    Department of Infectious Diseases, The University of Texas MD Anderson Cancer Center, Houston, TX, USA
    Bone Marrow Transplant 45:339-47. 2010
    ..On the basis of our results, we propose that NST recipients with lymphoma treated with high-dose corticosteroids for GVHD be considered for antifungal prophylaxis or pre-emptive antifungal therapy...
  21. ncbi Inhaled therapeutics for prevention and treatment of pneumonia
    Amar Safdar
    The University of Texas, Department of Infectious Diseases, M D Anderson Cancer Center, Infection Control and Employee Health, 402, 1515 Holcombe Boulevard, Texas 77030, Houston, USA
    Expert Opin Drug Saf 8:435-49. 2009
    ..These therapeutics are still in their infancy but show great promise...
  22. ncbi De novo T-lymphocyte responses against baculovirus-derived recombinant influenzavirus hemagglutinin generated by a naive umbilical cord blood model of dendritic cell vaccination
    Amar Safdar
    Department of Infectious Diseases, Infection Control, and Employee Health, University of Texas, M D Anderson Cancer Center, Houston, TX 77030, United States
    Vaccine 27:1479-84. 2009
    ....
  23. pmc Antimicrobial activities against 84 Listeria monocytogenes isolates from patients with systemic listeriosis at a comprehensive cancer center (1955-1997)
    Amar Safdar
    Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    J Clin Microbiol 41:483-5. 2003
    ....
  24. ncbi Clinical microbiological case: severe relapsing septal panniculitis in a healthy man from the south-eastern USA
    A Safdar
    Division of Infectious Diseases, Department of Medicine, University of South Carolina School of Medicine, Columbia, USA
    Clin Microbiol Infect 8:801-2; 830-2. 2002
  25. ncbi Clinical microbiological case: infection imitating lymphocutaneous sporotrichosis during pregnancy in a healthy woman from the south-eastern USA
    A Safdar
    Department of Infectious Diseases, Infection Control, and Employee Health, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Clin Microbiol Infect 9:221, 244-6. 2003
  26. ncbi Breakthrough Scedosporium apiospermum (Pseudallescheria boydii) brain abscess during therapy for invasive pulmonary aspergillosis following high-risk allogeneic hematopoietic stem cell transplantation. Scedosporiasis and recent advances in antifungal ther
    A Safdar
    Infectious Diseases, Memorial Sloan Kettering Cancer Center, New York, NY, USA
    Transpl Infect Dis 4:212-7. 2002
    ....
  27. ncbi Candida glabrata and Candida krusei fungemia after high-risk allogeneic marrow transplantation: no adverse effect of low-dose fluconazole prophylaxis on incidence and outcome
    A Safdar
    Division of Infectious Diseases, Department of Medicine, University of South Carolina School of Medicine, Columbia, SC 29203, USA
    Bone Marrow Transplant 28:873-8. 2001
    ..krusei breakthrough infections was similar to what is seen with high-dose fluconazole (400 mg) prophylaxis, and no adverse effects of low-dose fluconazole in terms of increased incidence of non-susceptible Candida species was seen...
  28. ncbi Fatal cytomegalovirus pneumonia in patients with haematological malignancies: an autopsy-based case-control study
    H A Torres
    Department of Infectious Diseases, Infection Control, and Employee Health, The University of Texas, M D Anderson Cancer Center, Houston, TX 77230 1402, USA
    Clin Microbiol Infect 14:1160-6. 2008
    ..Complete remission of an HM does not preclude the development of CMV pneumonia among patients with prolonged lymphopenia...
  29. ncbi Fungal endophthalmitis in a tertiary care cancer center: a review of 23 cases
    G A Lamaris
    Department of Infectious Diseases, Infection Control and Employee Health, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Eur J Clin Microbiol Infect Dis 27:343-7. 2008
    ..FE in cancer patients occurs in the setting of severe, frequently disseminated opportunistic mycoses, is caused predominantly by hyalohyphomycetes, and is a marker for high 4-week mortality...
  30. ncbi Stenotrophomonas maltophilia pneumonia in cancer patients without traditional risk factors for infection, 1997-2004
    G Aisenberg
    Department of Infectious Diseases, Infection Control, and Employee Health, Unit 402, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Eur J Clin Microbiol Infect Dis 26:13-20. 2007
    ..51-241.2; p < 0.0006). The results of this study indicate S. maltophilia pneumonia is a serious infection even in non-neutropenic, non-ICU patients with cancer...
  31. ncbi Streptococcus pneumoniae infections in 47 hematopoietic stem cell transplantation recipients: clinical characteristics of infections and vaccine-breakthrough infections, 1989-2005
    Souad Youssef
    Department of Infectious Diseases, M D Anderson Cancer Center, Houston, Texas 77030, USA
    Medicine (Baltimore) 86:69-77. 2007
    ..It is noteworthy that there were no cases of extrapulmonary organ infection in HSCT recipients who presented with S. pneumoniae infection at our institution...
  32. ncbi Inhaled aminoglycosides in cancer patients with ventilator-associated Gram-negative bacterial pneumonia: safety and feasibility in the era of escalating drug resistance
    D E Ghannam
    Department of Infectious Diseases, Infection Control, and Employee Health, Unit 402, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
    Eur J Clin Microbiol Infect Dis 28:253-9. 2009
    ..7; 95% CI, 3.3, 412.2; P < 0.003). In critically ill cancer patients with Gram-negative VAP, inhaled aminoglycosides were tolerated without serious toxicity and may lead to improved outcome...
  33. ncbi Influence of type of cancer and hematopoietic stem cell transplantation on clinical presentation of Pneumocystis jiroveci pneumonia in cancer patients
    H A Torres
    Department of Infectious Diseases, Infection Control and Employee Health, The University of Texas M D Anderson Cancer Center, Houston, TX, USA
    Eur J Clin Microbiol Infect Dis 25:382-8. 2006
    ..jiroveci pneumonia in cancer patients may be affected by the category of cancer and the history of hematopoietic stem cell transplantation. P. jiroveci pneumonia remains a rare yet severe infection in cancer patients...
  34. ncbi Hematogenous infections due to Candida parapsilosis: changing trends in fungemic patients at a comprehensive cancer center during the last four decades
    Amar Safdar
    Departments of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York, USA
    Diagn Microbiol Infect Dis 44:11-6. 2002
    ..parapsilosis infection. This study emphasizes the importance of periodic evaluation of candidemia, especially at centers caring for patients at risk...
  35. ncbi Fungal osteoarticular infections in patients treated at a comprehensive cancer centre: a 10-year retrospective review
    P R Kumashi
    Department of Infectious Diseases, Infection Control and Employee Health, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Clin Microbiol Infect 12:621-6. 2006
    ..FOAI is a rare, yet severe, manifestation of localised or systemic mycoses, caused predominantly by moulds, and is seen typically in patients with haematological malignancies...
  36. ncbi Infectious morbidity in critically ill patients with cancer
    A Safdar
    Department of Medicine, Division of Infectious Diseases, University of South Carolina School of Medicine, Columbia, South Carolina, USA
    Crit Care Clin 17:531-70, vii-viii. 2001
    ..The immune dysfunction may be caused by the underlying malignancy, by antineoplastic chemotherapy, or by invasive procedures during supportive care...
  37. ncbi Listeriosis in recipients of allogeneic blood and marrow transplantation: thirteen year review of disease characteristics, treatment outcomes and a new association with human cytomegalovirus infection
    A Safdar
    Infectious Diseases Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, Weill Medical College of Cornell University, New York, NY, USA
    Bone Marrow Transplant 29:913-6. 2002
    ..The association between primary HCMV reactivation and subsequent listeric infection emphasizes the significance of HCMV-related dysfunction in hosts' cellular immune responses, especially in the setting of allogeneic transplantation...
  38. ncbi Prospective evaluation of Candida species colonization in hospitalized cancer patients: impact on short-term survival in recipients of marrow transplantation and patients with hematological malignancies
    A Safdar
    Infectious Diseases Service, Department of Medicine, Memorial Sloan Kettering Cancer Center MSKCC, New York, NY, USA
    Bone Marrow Transplant 30:931-5. 2002
    ..1%) (P < 0.025). This study shows that patients with hematologic cancer and recipients of marrow transplant with Candida colonization of multiple body sites, and colonization with C. glabata or C. krusei have poor survival...
  39. ncbi Polymicrobial infection in patients with cancer: an underappreciated and underreported entity
    Kenneth V I Rolston
    The University of Texas, M D Anderson Cancer Center, Houston, TX 77030, USA
    Clin Infect Dis 45:228-33. 2007
    ....
  40. pmc Prospective study of Candida species in patients at a comprehensive cancer center
    A Safdar
    Infectious Diseases Service, Department of Medicine, Memorial Sloan-Kettering Cancer Center and Department of Medicine, Weill Medical College of Cornell University, New York, USA
    Antimicrob Agents Chemother 45:2129-33. 2001
    ..4). This study reinforces the importance of periodic, prospective surveillance of clinical fungal isolates to determine appropriate prophylactic, empiric, and preemptive antifungal therapy for the highly susceptible patient population...
  41. ncbi Inhaled corticosteroids stabilize constrictive bronchiolitis after hematopoietic stem cell transplantation
    L Bashoura
    Department of Pulmonary Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
    Bone Marrow Transplant 41:63-7. 2008
    ..We conclude that high-dose inhaled corticosteroids may be effective in the treatment of PTCB and propose a plausible mechanism of its action. A prospective evaluation of its efficacy is warranted...
  42. ncbi Oral topical cidofovir: novel route of drug delivery in a severely immunosuppressed patient with refractory multidrug-resistant herpes simplex virus infection
    C R Sims
    Department of Infectious Diseases, Infection Control, and Employee Health, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Transpl Infect Dis 9:256-9. 2007
    ..The use of 3% cidofovir in a saline rinse for refractory mucosal HSV infection appears promising but needs prospective evaluation...
  43. ncbi Candidemia in a tertiary care cancer center: in vitro susceptibility and its association with outcome of initial antifungal therapy
    Anastasia Antoniadou
    Department of Infectious Diseases, Infection Control and Employee Health, Unit 402, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
    Medicine (Baltimore) 82:309-21. 2003
    ..04, but not in univariate analysis), indicating the complexity of the variables that influence the response to antifungal treatment in cancer patients with candidemia...
  44. pmc Prospective, multicenter surveillance study of Candida glabrata: fluconazole and itraconazole susceptibility profiles in bloodstream, invasive, and colonizing strains and differences between isolates from three urban teaching hospitals in New York City (C
    Amar Safdar
    Infectious Diseases Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York, USA
    Antimicrob Agents Chemother 46:3268-72. 2002
    ..glabrata organisms isolated from hospitals in the same geographic region emphasizes the significance of periodic susceptibility surveillance programs for individual institutions, especially those providing care to patients at risk...
  45. ncbi Bioimmunoadjuvants for the treatment of neoplastic and infectious disease: Coley's legacy revisited
    William K Decker
    Department of Stem Cell Transplantation and Cellular Therapy, University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Cytokine Growth Factor Rev 20:271-81. 2009
    ..The discussion is limited to molecules that have been able to show therapeutic promise in the clinical setting...
  46. ncbi Neuraminidase inhibitors improve outcome of patients with leukemia and influenza: an observational study
    Roy F Chemaly
    Department of Infectious Diseases, Infection Control, and Employee Health, The University of Texas M D Anderson Cancer Center, Houston, TX 77230 1402, USA
    Clin Infect Dis 44:964-7. 2007
    ..001). The use of neuraminidase inhibitor therapy seems to improve the outcome of influenza in patients with leukemia...
  47. ncbi Respiratory viral infections in adults with hematologic malignancies and human stem cell transplantation recipients: a retrospective study at a major cancer center
    Roy F Chemaly
    Department of Infectious Diseases, Infection Control and Employee Health, University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Medicine (Baltimore) 85:278-87. 2006
    ..HSCT recipients and patients with hematologic malignancies who develop upper respiratory infection due to CRVs should be considered for antiviral therapy of proven efficacy to reduce the risk of pneumonia and death...
  48. ncbi Zygomycosis in a tertiary-care cancer center in the era of Aspergillus-active antifungal therapy: a case-control observational study of 27 recent cases
    Dimitrios P Kontoyiannis
    Department of Infectious Diseases, Infection Control, and Employee Health, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    J Infect Dis 191:1350-60. 2005
    ..Anecdotal evidence suggests a rise in zygomycosis in association with voriconazole (VRC) use in immunosuppressed patients...
  49. ncbi Antimicrobial susceptibility of 128 Salmonella enterica serovar typhi and paratyphi A isolates from northern India
    Amar Safdar
    Department of Infectious Diseases, Infection Control, and Employee Health, The University of Texas MD Anderson Cancer Center, Houston, USA
    Chemotherapy 50:88-91. 2004
    ..Ceftriaxone and ciprofloxacin remain favorable choices for treatment of patients with enteric fever in this region...
  50. ncbi Central venous catheter and Stenotrophomonas maltophilia bacteremia in cancer patients
    Maha Boktour
    Department of Infectious Diseases, Infection Control and Employee Health, University of Texas M D Anderson Cancer Center, Houston, Texas 77230, USA
    Cancer 106:1967-73. 2006
    ..Stenotrophomonas maltophilia bacteremia is frequently found in cancer patients. This study attempted to determine how often the catheters were the source of this infection and the risk factors associated with catheter-related bacteremias...
  51. pmc Francisella tularensis peritonitis in stomach cancer patient
    Xiang Y Han
    University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Emerg Infect Dis 10:2238-40. 2004
    ..holarctica, which was identified by sequencing analysis of the 16S rDNA. The infection resolved with antimicrobial treatment. Antibodies detected 4 weeks after onset disappeared after chemotherapy-associated lymphopenia...
  52. doi Dendritic cell vaccines for the immunocompromised patient: prevention of influenza virus infection
    William K Decker
    Department of Stem Cell Transplantation and Cellular Therapy, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
    Expert Rev Vaccines 9:721-30. 2010
    ..The results suggest that DC immunotherapy for influenza prophylaxis is safe and feasible and that clinical studies might be warranted...
  53. ncbi Prospective epidemiologic analysis of triazole-resistant nosocomial Candida glabrata isolated from patients at a comprehensive cancer center
    Amar Safdar
    Infectious Diseases Service, Department of Medicine, Memorial Sloan Kettering Cancer Center and Department of Medicine, Weill Medical College of Cornell University, New York, USA
    Int J Infect Dis 6:198-201. 2002
    ..The emergence of Candida glabrata infections among patients with compromised immunity has become a serious concern, especially at centers caring for individuals with cancer...
  54. ncbi Invasive fungal infections in patients with hematologic malignancies in a tertiary care cancer center: an autopsy study over a 15-year period (1989-2003)
    Georgios Chamilos
    Department of Infectious Diseases, Infection Control and Employee Health, Unit 402, Laboratory Medicine, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX 77030, USA
    Haematologica 91:986-9. 2006
    ..The complex and evolving epidemiology of IFI in severely immunocompromised patients is not well captured by current diagnostic methods...
  55. ncbi Mycobacterium tuberculosis at a comprehensive cancer centre: active disease in patients with underlying malignancy during 1990-2000
    G R De La Rosa
    The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
    Clin Microbiol Infect 10:749-52. 2004
    ..001; OR 8.67). At this institution, active tuberculosis was rare, and was seen mostly in immigrants. Recent high-dose corticosteroid therapy is a significant predictor of mortality in cancer patients with tuberculosis...
  56. ncbi Infections in 100 cord blood transplantations: spectrum of early and late posttransplant infections in adult and pediatric patients 1996-2005
    Amar Safdar
    Department of Infectious Diseases, Infection Control, and Employee Health, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Medicine (Baltimore) 86:324-33. 2007
    ..47; p < 0.007) were less likely to die from infection. More effective measures for surveillance and prevention of late cytomegalovirus and varicella zoster virus infections in children with CBT and chronic GVHD are needed...
  57. ncbi Bacteremia caused by Achromobacter and Alcaligenes species in 46 patients with cancer (1989-2003)
    Gabriel Aisenberg
    Department of Infectious Diseases, Infection Control, and Employee Health, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Cancer 101:2134-40. 2004
    ..The authors sought to determine the incidence and characteristics of bloodstream infections caused by these organisms in patients with underlying malignancies...
  58. ncbi Streptococcus pneumoniae bacteremia in patients with cancer: disease characteristics and outcomes in the era of escalating drug resistance (1998-2002)
    Padmavati Kumashi
    Department of Infectious Diseases, Infection Control, and Employee Health, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Medicine (Baltimore) 84:303-12. 2005
    ..pneumoniae, and other conventional predictors of unfavorable outcome were not associated with increased mortality rates in these high-risk patients with cancer...
  59. ncbi Intracranial perineural extension of invasive mycosis: a novel mechanism of disease propagation by Aspergillus fumigatus
    Amar Safdar
    Division of Infectious Diseases, Department of Medicine, University of South Carolina School of Medicine, PalmettoRichland Memorial Hospital, Columbia, SC 29203, USA
    Clin Infect Dis 35:e50-3. 2002
    ..The patient responded to a combination of antifungal and adjuvant recombinant cytokine therapy...
  60. ncbi Extrapulmonary tuberculosis active infection misdiagnosed as cancer: Mycobacterium tuberculosis disease in patients at a Comprehensive Cancer Center (2001-2005)
    Gabriel M Aisenberg
    Department of Infectious Diseases, Infection Control, and Employee Health, The University of Texas MD Anderson Cancer Center, Houston, 77030, USA
    Cancer 104:2882-7. 2005
    ..S., even in immunosuppressed cancer patients. This study evaluated characteristics and frequency of extrapulmonary tuberculosis in patients at a tertiary care referral cancer center...
  61. ncbi Culture-positive and culture-negative endocarditis in patients with cancer: a retrospective observational study, 1994-2004
    Syed Wamique Yusuf
    Department of Cardiology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Medicine (Baltimore) 85:86-94. 2006
    ..The clinical spectrums of CPE and CNE differed in these patients with cancer. In patients with CNE, embolic cerebrovascular and fatal myocardial infarction were relatively common...
  62. ncbi Progressive cutaneous hyalohyphomycosis due to Paecilomyces lilacinus: rapid response to treatment with caspofungin and itraconazole
    Amar Safdar
    Division of Infectious Diseases, Department of Medicine, University of South Carolina School of Medicine, Columbia, SC 29203, USA
    Clin Infect Dis 34:1415-7. 2002
    ..The infection responded favorably to caspofungin and itraconazole combination therapy...
  63. ncbi Characteristics and outcome of respiratory syncytial virus infection in patients with leukemia
    Harrys A Torres
    Department of Infectious Diseases, Infection Control and Employee Health, The University of Texas M D Anderson Cancer Center, Houston, TX, USA
    Haematologica 92:1216-23. 2007
    ..The aim of this study was to determine the characteristics, and the outcome of RSV infection with or without therapy with aerosolized ribavirin in leukemia patients...
  64. ncbi The predictors of outcome in immunocompetent patients with hematogenous candidiasis
    Amar Safdar
    University of South Carolina School of Medicine, Columbia, SC 29203, USA
    Int J Infect Dis 8:180-6. 2004
    ..Clinical parameters that predict outcome in non-immunosuppressed candidemic patients are not fully understood...
  65. doi Herpes simplex virus lower respiratory tract infection in patients with solid tumors
    Gabriel M Aisenberg
    Department of Infectious Diseases, Infection Control, and Employee Health, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Cancer 115:199-206. 2009
    ..In the current study, the authors attempted to determine the clinical relevance of this finding among ST patients...
  66. ncbi Aerosolized ribavirin-induced reversible hepatotoxicity in a hematopoietic stem cell transplant recipient with Hodgkin lymphoma
    Jorge Chaves
    Department of Lymphoma and Myeloma, Section of Cytokines and Supportive Oncology, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Clin Infect Dis 42:e72-5. 2006
    ....
  67. ncbi Clinical microbiological case: cardiac tamponade due to hemorrhagic pericarditis in a non-immunocompromised woman from south-eastern United States
    A Safdar
    Division of Infectious Diseases, Department of Medicine, University of South Carolina School of Medicine, Columbia, SC 29203, USA
    Clin Microbiol Infect 8:243-4, 248-51. 2002
  68. ncbi Scedosporium infection in a tertiary care cancer center: a review of 25 cases from 1989-2006
    Gregory A Lamaris
    Department of Infectious Diseases, Infection Control and Employee Heath, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Clin Infect Dis 43:1580-4. 2006
    ..Cases of S. prolificans infection occurred only after 2000. Dissemination occurred in 16 patients (64%). The 12-week mortality rates were 70% and 100% for S. apiospermum and S. prolificans infection, respectively...
  69. ncbi Prosthetic valve endocarditis due to vancomycin-resistant Enterococcus faecium: treatment with chloramphenicol plus minocycline
    Amar Safdar
    Division of Infectious Diseases, Department of Medicine, University of South Carolina School of Medicine, Columbia, SC, 29203, USA
    Clin Infect Dis 34:E61-3. 2002
    ..The combination of parenteral chloramphenicol plus minocycline therapy was administered for 8 weeks and resulted in cure after treatment with quinupristin-dalfopristin had failed...
  70. ncbi Inactive pulmonary tuberculosis mimicking metastasis from papillary thyroid carcinoma in diagnostic radioiodine whole-body scintigraphy
    Michalis K Picolos
    Department of Endocrine Neoplasia and Hormonal Disorders, The University of Texas, M D Anderson Cancer Center, Houston, Texas 77030, USA
    Thyroid 15:1105-6. 2005
  71. doi Caspofungin-mediated beta-glucan unmasking and enhancement of human polymorphonuclear neutrophil activity against Aspergillus and non-Aspergillus hyphae
    Gregory A Lamaris
    Department of Infectious Diseases, Infection Control, and Employee Health, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    J Infect Dis 198:186-92. 2008
    ..We investigated whether caspofungin and other echinocandins have immune-enhancing properties that influence human polymorphonuclear neutrophil (PMN)-mediated mold hyphal damage...
  72. ncbi Prolonged candidemia in patients with cancer
    Amar Safdar
    Clin Infect Dis 35:778-9. 2002
  73. ncbi Efficacy of vancomycin plus levofloxacin combination therapy for refractory pericarditis due to multiresistant Streptococcus pneumoniae
    Amar Safdar
    Int J Infect Dis 7:287. 2003
  74. doi Progressive fusariosis: unpredictable posaconazole bioavailability, and feasibility of recombinant interferon-gamma plus granulocyte macrophage-colony stimulating factor for refractory disseminated infection
    Roshan Lewis
    Leuk Lymphoma 49:163-5. 2008
  75. doi Human herpesvirus-6 DNAemia in immunosuppressed adult patients with leukemia at risk for mold infection
    Roy F Chemaly
    Haematologica 93:157-8. 2008
    ..HHV-6 DNA was detected from whole blood specimens in 11 patients (30%). History of granulocyte transfusions (p=0.05) and prior relapse of leukemia (p=0.07) were the only independent predictors of HHV-6 DNAemia...
  76. ncbi Relationship of colonization with vancomycin-resistant enterococci and risk of systemic infection in patients with cancer
    Madonna J Matar
    Clin Infect Dis 42:1506-7. 2006
  77. ncbi Nocardia veterana bloodstream infection in a patient with cancer and a summary of reported cases
    Shoaib R Ansari
    Int J Infect Dis 10:483-6. 2006
  78. ncbi Infectious diarrhea in the southeastern United States, 1998-2000
    Amar Safdar
    Clin Infect Dis 36:533-4. 2003
  79. ncbi Rosai-Dorfman disease misdiagnosed as active tuberculosis
    Amar Safdar
    Leuk Lymphoma 47:1441-2. 2006