Research Topics
| ERKKI I RUOSLAHTISummaryAffiliation: The Burnham Institute Country: USA Publications
Research Grants
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Detail Information
Publications
Drug targeting to specific vascular sitesErkki Ruoslahti
Cancer Research Center, The Burnham Institute, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA
Drug Discov Today 7:1138-43. 2002..Targeting a therapy to the diseased tissue enhances the efficacy of the treatment while reducing the side effects in mouse experiments. Results from drug delivery to tumor vessels have been particularly encouraging...- Vascular homing peptides with cell-penetrating propertiesE Ruoslahti
The Burnham Institute, Cancer Research Center, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA
Curr Pharm Des 11:3655-60. 2005..The cell penetrating peptides may be particularly useful in drug delivery because they can take their payload inside the target cells and even into a specific subcellular organelle such as the nucleus... - Aminopeptidase N is a receptor for tumor-homing peptides and a target for inhibiting angiogenesisR Pasqualini
The Burnham Institute, La Jolla, California 92037, USA
Cancer Res 60:722-7. 2000..Thus, APN is involved in angiogenesis and can serve as a target for delivering drugs into tumors and for inhibiting angiogenesis... - Specialization of tumour vasculatureErkki Ruoslahti
Cancer Research Center, Burnham Institute, 10901 North Torrey Pines Road, La Jolla, California 92037, USA
Nat Rev Cancer 2:83-90. 2002..Some tumours also contain lymphatic vessels, as well as channels that consist of cancer cells and their extracellular matrix. These special features of tumour vessels are good targets for cancer therapies... - Antiangiogenics meet nanotechnologyErkki Ruoslahti
The Burnham Institute, La Jolla, California 92037, USA
Cancer Cell 2:97-8. 2002..A mutant Raf-1 gene loaded onto nanoparticles, delivered to tumor vasculature with an integrin binding compound, provides effective antiangiogenic gene therapy in mice... - Vascular zip codes in angiogenesis and metastasisE Ruoslahti
The Burnham Institute, Cancer Research Center, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA
Biochem Soc Trans 32:397-402. 2004..These phage-screening studies have revealed a previously unsuspected degree of vascular specialization and provide potentially useful guidance devices for targeted therapies... 
Targeting of drugs and nanoparticles to tumorsErkki Ruoslahti
Vascular Mapping Center, Sanford Burnham Medical Research Institute, University of California, Santa Barbara, Santa Barbara, CA 93106, USA
J Cell Biol 188:759-68. 2010..We review the recent advances in this delivery approach with a focus on the use of molecular markers of tumor vasculature as the primary target and nanoparticles as the delivery vehicle...- Targeting tumor vasculature with homing peptides from phage displayE Ruoslahti
Cancer Research Center, The Burnham Institute, La Jolla, California 92037, USA
Semin Cancer Biol 10:435-42. 2000..Such a targeting strategy can therefore potentially improve the efficacy of drugs and reduce their side effects... - The RGD story: a personal accountErkki Ruoslahti
The Burnham Institute, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA
Matrix Biol 22:459-65. 2003 - Nanocrystal targeting in vivoMaria E Akerman
Cancer Research Center, The Burnham Institute, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA
Proc Natl Acad Sci U S A 99:12617-21. 2002..These results encourage the construction of more complex nanostructures with capabilities such as disease sensing and drug delivery... - Tissue-penetrating delivery of compounds and nanoparticles into tumorsKazuki N Sugahara
Vascular Mapping Center, Burnham Institute for Medical Research at UCSB, Biology II Building, University of California, Santa Barbara, Santa Barbara, CA 93106 9610, USA
Cancer Cell 16:510-20. 2009..Conjugation to iRGD significantly improved the sensitivity of tumor-imaging agents and enhanced the activity of an antitumor drug... - Nanoparticle-induced vascular blockade in human prostate cancerLilach Agemy
Vascular Mapping Laboratory, Center for Nanomedicine, Sanford Burnham Medical Research Institute at the University of California at Santa Barbara UCSB, Santa Barbara, CA, USA
Blood 116:2847-56. 2010..Treatment of mice with prostate cancer with multiple doses of the nanoworms induced tumor necrosis and a highly significant reduction in tumor growth... - A tumor-homing peptide with a targeting specificity related to lymphatic vesselsPirjo Laakkonen
Cancer Research Center, The Burnham Institute, La Jolla, California, USA
Nat Med 8:751-5. 2002..These results suggest that tumor lymphatics carry specific markers and that it may be possible to specifically target therapies into tumor lymphatics... - Targeting of albumin-embedded paclitaxel nanoparticles to tumorsPriya Prakash Karmali
Vascular Mapping Center, Burnham Institute for Medical Research at UCSB, University of California, Santa Barbara, California 93106 9610, USA
Nanomedicine 5:73-82. 2009..These results show that nanoparticles can be effectively targeted into extravascular tumor tissue and that targeting can enhance the activity of a therapeutic nanoparticle... - Molecular changes in the vasculature of injured tissuesTero A H Järvinen
Cancer Research Center, Burnham Institute for Medical Research, La Jolla, CA, USA
Am J Pathol 171:702-11. 2007..The peptides recognizing these markers may be useful in delivering treatments into regenerating tissues... - Lymphatic zip codes in premalignant lesions and tumorsLianglin Zhang
Cancer Research Center and Program in Molecular Pathology, Burnham Institute for Medical Research, La Jolla, California, USA
Cancer Res 66:5696-706. 2006.... - Peptides selected for binding to clotted plasma accumulate in tumor stroma and woundsJan Pilch
Burnham Institute for Medical Research, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA
Proc Natl Acad Sci U S A 103:2800-4. 2006..These peptides may be useful in targeting diagnostic and therapeutic materials into tumors and injured tissues... - Molecular specialization of breast vasculature: a breast-homing phage-displayed peptide binds to aminopeptidase P in breast vasculatureMarkus Essler
Cancer Research Center, The Burnham Institute, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA
Proc Natl Acad Sci U S A 99:2252-7. 2002..These results indicate that aminopeptidase P is the receptor for the breast-homing peptide. This peptide may be useful in designing drugs for the prevention and treatment of breast cancer... - C-end rule peptides mediate neuropilin-1-dependent cell, vascular, and tissue penetrationTambet Teesalu
Vascular Mapping Center, The Burnham Institute for Medical Research at University of California, Santa Barbara, CA 93106 9610, USA
Proc Natl Acad Sci U S A 106:16157-62. 2009..The peptides were able to take payloads up to the nanoparticle size scale deep into extravascular tissue. Our observations have implications in drug delivery and penetration of tissue barriers and tumors... - Molecular profiling of heart endothelial cellsLianglin Zhang
Cancer Research Center, The Burnham Institute, La Jolla, CA 92037, USA
Circulation 112:1601-11. 2005..The heart-homing peptides provide a means of targeting diagnostic and therapeutic agents to the heart, and their receptors are potential drug discovery targets... - Antiangiogenic proteins require plasma fibronectin or vitronectin for in vivo activityMing Yi
Cancer Research Center, The Burnham Institute, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA
Proc Natl Acad Sci U S A 100:11435-8. 2003.... 
Nucleolin expressed at the cell surface is a marker of endothelial cells in angiogenic blood vesselsSven Christian
Cancer Research Center, The Burnham Institute, La Jolla, CA 92037 3198, USA
J Cell Biol 163:871-8. 2003..These results show that cell surface nucleolin is a specific marker of angiogenic endothelial cells within the vasculature. It may be a useful target molecule for diagnostic tests and drug delivery applications...- Biomimetic amplification of nanoparticle homing to tumorsDmitri Simberg
Cancer Research Center, Burnham Institute for Medical Research, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA
Proc Natl Acad Sci U S A 104:932-6. 2007..The self-amplifying homing is a novel function for nanoparticles. The clotting-based amplification greatly enhances tumor imaging, and the addition of a drug carrier function to the particles is envisioned... - Stage-specific vascular markers revealed by phage display in a mouse model of pancreatic islet tumorigenesisJohanna A Joyce
Department of Biochemistry and Biophysics, Diabetes and Comprehensive Cancer Centers, University of California, San Francisco, 513 Parnassus Avenue, San Francisco, CA 94143, USA
Cancer Cell 4:393-403. 2003..One peptide is homologous with pro-PDGF-B, which is expressed in endothelial cells, while its receptor is expressed in pericytes... - Angiostatic peptides use plasma fibronectin to home to angiogenic vasculatureMaria E Akerman
Cancer Research Center, The Burnham Institute, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA
Proc Natl Acad Sci U S A 102:2040-5. 2005..This functional convergence of several antiangiogenic factors has important implications for antiangiogenic therapies... - Metadherin, a cell surface protein in breast tumors that mediates lung metastasisDarren M Brown
Cancer Research Center, The Burnham Institute, 10901 North Torrey Pines Road, La Jolla, CA 92037 USA
Cancer Cell 5:365-74. 2004.... - Targeted quantum dot conjugates for siRNA deliveryAustin M Derfus
Department of Bioengineering, University of California at San Diego, La Jolla, California 92093, USA
Bioconjug Chem 18:1391-6. 2007..By designing the siRNA sequence against a therapeutic target (e.g., oncogene) instead of EGFP, this technology may be ultimately adapted to simultaneously treat and image metastatic cancer... - Coadministration of a tumor-penetrating peptide enhances the efficacy of cancer drugsKazuki N Sugahara
Vascular Mapping Laboratory, Center for Nanomedicine, Sanford Burnham Medical Research Institute at University of California at Santa Barbara, Biology II Building, University of California, Santa Barbara, CA 93106 9610, USA
Science 328:1031-5. 2010..Thus, coadministration of iRGD may be a valuable way to enhance the efficacy of anticancer drugs while reducing their side effects, a primary goal of cancer therapy research... - Contact activation of kallikrein-kinin system by superparamagnetic iron oxide nanoparticles in vitro and in vivoDmitri Simberg
Nano Tumor Center of Excellence for Cancer Nanotechnology, Moores UCSD Cancer Center, 3855 Health Sciences Drive, La Jolla, CA 92093, USA
J Control Release 140:301-5. 2009..These data could help in understanding the toxicity of nanomaterials and could be used in designing nanoparticles with controlled enzymatic activity... - Biodegradable luminescent porous silicon nanoparticles for in vivo applicationsJi Ho Park
Department of Chemistry and Biochemistry, University of California, San Diego, La Jolla, California 92093, USA
Nat Mater 8:331-6. 2009..These results demonstrate a new type of multifunctional nanostructure with a low-toxicity degradation pathway for in vivo applications... - Progressive vascular changes in a transgenic mouse model of squamous cell carcinomaJason A Hoffman
Cancer Research Center, The Burnham Institute, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA
Cancer Cell 4:383-91. 2003..Thus, characteristics of the angiogenic vasculature distinguish premalignant and malignant stages of skin tumorigenesis... - Antitumor activity of a homing peptide that targets tumor lymphatics and tumor cellsPirjo Laakkonen
The Burnham Institute, La Jolla, CA 92037
Proc Natl Acad Sci U S A 101:9381-6. 2004..As LyP-1 affects the poorly vascularized tumor compartment, it may complement treatments directed at tumor blood vessels... - Protein kinase D is a positive regulator of Bit1 apoptotic functionHector Biliran
Burnham Institute for Medical Research at the University of California Santa Barbara, University of California, Santa Barbara, California 93106 9610, USA
J Biol Chem 283:28029-37. 2008..These studies identify the PKD serine/threonine kinase as one of the signaling molecules through which integrin-mediated cell attachment controls Bit1 activity and anoikis... - Cooperative nanomaterial system to sensitize, target, and treat tumorsJi Ho Park
Materials Science and Engineering Program, University of California, San Diego, La Jolla, CA 92093, USA
Proc Natl Acad Sci U S A 107:981-6. 2010..Mice containing xenografted MDA-MB-435 tumors that are treated with the combined NR/LyP-1LP therapeutic system display significant reductions in tumor volume compared with individual nanoparticles or untargeted cooperative system... - Systematic surface engineering of magnetic nanoworms for in vivo tumor targetingJi Ho Park
Materials Science and Engineering Program Department of Chemistry and Biochemistry University of California, San Diego 9500 Gilman, La Jolla, CA 92093, USA
Small 5:694-700. 2009..It is concluded that the blood half-life of a targeting molecule-nanomaterial ensemble is a key consideration when selecting the appropriate ligand and nanoparticle chemistry for tumor targeting... - Targeting the prostate for destruction through a vascular addressWadih Arap
Cancer Research Center, The Burnham Institute, La Jolla, CA 92037, USA
Proc Natl Acad Sci U S A 99:1527-31. 2002..These results suggest that it may be possible to develop an alternative to surgical prostate resection and that such a treatment may also reduce future cancer risk... - Differential proteomics analysis of the surface heterogeneity of dextran iron oxide nanoparticles and the implications for their in vivo clearanceDmitri Simberg
Moores UCSD Cancer Center, 3855 Health Sciences Drive, La Jolla, CA 92093, USA
Biomaterials 30:3926-33. 2009..These data provide guidance to rational design of bioinert, long-circulating nanoparticles... 
Cell surface nucleolin antagonist causes endothelial cell apoptosis and normalization of tumor vasculatureValentina Fogal
Cancer Research Center, Burnham Institute for Medical Research, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA
Angiogenesis 12:91-100. 2009..These data reveal a novel mode of action for anti-angiogenic therapy and identify cell surface nucleolin as a novel target for combinatorial chemotherapy...- Anastellin, an FN3 fragment with fibronectin polymerization activity, resembles amyloid fibril precursorsKlára Briknarová
The Burnham Institute, 10901 North Torrey Pines Road, La Jolla, CA 92037 1062, USA
J Mol Biol 332:205-15. 2003..We suggest that this analogy is not random and may reflect similarities between fibronectin and amyloid fibril formation... - Mitochondrial p32 protein is a critical regulator of tumor metabolism via maintenance of oxidative phosphorylationValentina Fogal
Cancer Research Center, Burnham Institute for Medical Research, 10901 N Torrey Pines Rd, La Jolla, California 92037, USA
Mol Cell Biol 30:1303-18. 2010.... - Identification of endothelial genes up-regulated in vivoJih-Tung Pai
Cancer Research Center, The Burnham Institute, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA
Gene 347:21-33. 2005..In summary, the genes we have identified represent potentially new pan-endothelial and tissue-specific endothelial markers... - Micellar hybrid nanoparticles for simultaneous magnetofluorescent imaging and drug deliveryJi-Ho Park
Materials Science and Engineering Program, Department of Chemistry and Biochemistry, University of California, San Diego, 9500 Gilman, La Jolla, CA 92093, USA
Angew Chem Int Ed Engl 47:7284-8. 2008 - Dynamic imaging of arginine-rich heart-targeted vehicles in a mouse modelHua Zhang
Department of Biomedical Engineering, University of California, Davis, CA 95616, USA
Biomaterials 29:1976-88. 2008..The rapid and efficient targeting of these particles can be exploited in drug and gene delivery systems and with dynamic positron emission tomography provides a model system to optimize targeting of engineered particles... - R-Ras is a global regulator of vascular regeneration that suppresses intimal hyperplasia and tumor angiogenesisMasanobu Komatsu
Burnham Institute for Medical Research, Cancer Research Center, 10901 North Torrey Pines Road, La Jolla, California 92037, USA
Nat Med 11:1346-50. 2005..These results establish an unexpected role for R-Ras in blood vessel homeostasis and suggest that R-Ras signaling may offer a target for therapeutic intervention in vascular diseases... - A fragment of the HMGN2 protein homes to the nuclei of tumor cells and tumor endothelial cells in vivoKimmo Porkka
Cancer Research Center, The Burnham Institute, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA
Proc Natl Acad Sci U S A 99:7444-9. 2002..Thus, F3 can carry a payload (phage, fluorescein) to a tumor and into the cell nuclei in the tumor. This peptide may be suitable for targeting cytotoxic drugs and gene therapy vectors into tumors... - Drug identification through in vivo screening of chemical librariesDarren M Brown
Cancer Research Center, The Burnham Institute, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA
Chembiochem 5:871-5. 2004 - A mitochondrial protein, Bit1, mediates apoptosis regulated by integrins and Groucho/TLE corepressorsYiwen Jan
Cancer Research Center, The Burnham Institute, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA
Cell 116:751-62. 2004..Thus, we have elucidated an integrin-controlled pathway that is, at least in part, responsible for the cell survival effects of cell-ECM interactions... - Ligand-modified vesicular stomatitis virus glycoprotein displays a temperature-sensitive intracellular trafficking and virus assembly phenotypeGhiabe H Guibinga
Department of Pediatrics, Center for Molecular Genetics, University of California at San Diego School of Medicine, La Jolla, CA 92093-0634, USA
Mol Ther 9:76-84. 2004.... - Activated SRC oncogene phosphorylates R-ras and suppresses integrin activityJune X Zou
Cancer Research Center, The Burnham Institute, La Jolla, California 92037, USA
J Biol Chem 277:1824-7. 2002..Regulation of cell adhesion by Src through R-Ras may be at least partially responsible for the reduced adhesion and the resulting increased invasiveness of Src-transformed cells... - Synthetic surfaces for human embryonic stem cell culturePoornima Kolhar
Biomolecular Science and Engineering, University of California, Santa Barbara, CA 93106, USA
J Biotechnol 146:143-6. 2010..We have developed a novel peptide-based surface that uses a high-affinity cyclic RGD peptide for culture of hESCs under chemically defined conditions... - Mitochondrial/cell-surface protein p32/gC1qR as a molecular target in tumor cells and tumor stromaValentina Fogal
Cancer Research Center, Burnham Institute for Medical Research, La Jolla, California, USA
Cancer Res 68:7210-8. 2008..Its unique localization in tumors and its relative tumor specificity may make p32 a useful target in tumor diagnosis and therapy... - Trophoblast cell activation by trophinin ligation is implicated in human embryo implantationKazuhiro Sugihara
Cancer Research Center and Inflammation and Infectious Disease Center, Burnham Institute for Medical Research, 10901 North Torrey Pines Road, La Jolla, CA 92037
Proc Natl Acad Sci U S A 104:3799-804. 2007..These results suggest that trophinin-mediated cell adhesion functions as a molecular switch for trophectoderm activation in human embryo implantation... - Crystal structure of a human peptidyl-tRNA hydrolase reveals a new fold and suggests basis for a bifunctional activityJose M de Pereda
Program on Cell Adhesion and Signal Transduction, Cancer Center of the Burnham Institute, La Jolla, California 92037, USA
J Biol Chem 279:8111-5. 2004..This active site architecture is unrelated to that of E. coli Pth. In addition, intermolecular contacts in the crystal asymmetric unit cell suggest a likely surface for protein-protein interactions related to the Pth2-mediated apoptosis...
Research Grants
- Regulation of Apoptosis by IntegrinsErkki Ruoslahti; Fiscal Year: 2007..Cells that become malignant may bypass this pathway in becoming anchorage independent and metastatic. ..
- ANGIOGENESIS INHIBITORS: A MECHANISM OF ACTIONErkki Ruoslahti; Fiscal Year: 2006..This study may provide important information on the mechanism of action of a class of angiogenesis inhibitors, information that may prove helpful in designing clinical trials for these compounds. ..
- Molecular Specialization of Tumor LymphaticsErkki Ruoslahti; Fiscal Year: 2007..Promising compounds emerging from these experiments will be tested in pre-clinical cancer models for treatment of cancer and prevention of metastasis. ..
- INTEGRIN REGULATION BY R-RASErkki Ruoslahti; Fiscal Year: 2002..As the R-ras interactions we have uncovered are novel for the Ras protein superfamily, new information on this important family of cellular regulators and oncoproteins will ensue. ..
- TUMOR CELLS IN CIRCULATIONErkki Ruoslahti; Fiscal Year: 2001..Finally, the ability to eliminate tumor cells from the circulation by sFN administration may provide additional protection against tumor cell transfer in bone marrow transplantation used to treat cancer and against tumor metastasis. ..
- TISSUE TARGETING WITH PHAGE LIBRARIESErkki Ruoslahti; Fiscal Year: 2001..Major advances in tumor therapies could be realized with this technology. Valuable information on the distinguishing characteristics of different vascular beds, including those undergoing angiogenesis, is also likely to ensue. ..