ZAVERIO RUGGERI

Summary

Affiliation: The Scripps Research Institute
Country: USA

Publications

  1. pmc Talin is required for integrin-mediated platelet function in hemostasis and thrombosis
    Brian G Petrich
    Department of Medicine, University of California, San Diego, La Jolla, CA 92093, USA
    J Exp Med 204:3103-11. 2007
  2. ncbi request reprint Modulation of alpha-thrombin function by distinct interactions with platelet glycoprotein Ibalpha
    Reha Celikel
    Roon Research Center for Arteriosclerosis and Thrombosis, Division of Experimental Thrombosis and Hemostasis, Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Science 301:218-21. 2003
  3. pmc Activation-independent platelet adhesion and aggregation under elevated shear stress
    Zaverio M Ruggeri
    The Scripps Research Institute MEM 175, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Blood 108:1903-10. 2006
  4. pmc Comparison of VerifyNow-P2Y12 test and Flow Cytometry for monitoring individual platelet response to clopidogrel. What is the cut-off value for identifying patients who are low responders to clopidogrel therapy?
    Cosmo Godino
    Department of Cardio Thoracic and Vascular Diseases, San Raffaele Scientific Institute, Milan, Italy
    Thromb J 7:4. 2009
  5. ncbi request reprint Type IIB von Willebrand disease: a paradox explains how von Willebrand factor works
    Z M Ruggeri
    Roon Center for Arteriosclerosis and Thrombosis, Division of Experimental Hemostasis and Thrombosis, Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, CA 92037, USA
    J Thromb Haemost 2:2-6. 2004
  6. ncbi request reprint Platelet and von Willebrand factor interactions at the vessel wall
    Z M Ruggeri
    Roon Center for Arteriosclerosis and Thrombosis, Division of Experimental Hemostasis and Thrombosis, Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, CA 92037, USA
    Hamostaseologie 24:1-11. 2004
  7. doi request reprint Unravelling the mechanism and significance of thrombin binding to platelet glycoprotein Ib
    Zaverio M Ruggeri
    Roon Research Center for Arteriosclerosis and Thrombosis, Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, California 92037, USA
    Thromb Haemost 104:894-902. 2010
  8. ncbi request reprint Platelet interactions with vessel wall components during thrombogenesis
    Zaverio M Ruggeri
    Roon Center for Arteriosclerosis and Thrombosis, Division of Experimental Hemostasis and Thrombosis, Department of Molecular and Experimental Medicine, The Scripps Research Institute MEM 175, La Jolla, CA 92037, USA
    Blood Cells Mol Dis 36:145-7. 2006
  9. pmc The role of von Willebrand factor in thrombus formation
    Zaverio M Ruggeri
    The Scripps Research Institute, La Jolla, California, USA
    Thromb Res 120:S5-9. 2007
  10. ncbi request reprint Adhesion mechanisms in platelet function
    Zaverio M Ruggeri
    The Roon Research Center for Arteriosclerosis and Thrombosis, Division of Blood Cell and Vascular Biology, Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, CA 92037, USA
    Circ Res 100:1673-85. 2007

Research Grants

Collaborators

Detail Information

Publications53

  1. pmc Talin is required for integrin-mediated platelet function in hemostasis and thrombosis
    Brian G Petrich
    Department of Medicine, University of California, San Diego, La Jolla, CA 92093, USA
    J Exp Med 204:3103-11. 2007
    ..These data establish that platelet talin plays a crucial role in hemostasis and provide the first proof that talin is required for the activation and function of mammalian alpha2beta1 and alphaIIbbeta3 integrins in vivo...
  2. ncbi request reprint Modulation of alpha-thrombin function by distinct interactions with platelet glycoprotein Ibalpha
    Reha Celikel
    Roon Research Center for Arteriosclerosis and Thrombosis, Division of Experimental Thrombosis and Hemostasis, Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Science 301:218-21. 2003
    ..These interactions may modulate alpha-thrombin function by mediating GpIbalpha clustering and cleavage of protease-activated receptors, which promote platelet activation, while limiting fibrinogen clotting through blockade of exosite I...
  3. pmc Activation-independent platelet adhesion and aggregation under elevated shear stress
    Zaverio M Ruggeri
    The Scripps Research Institute MEM 175, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Blood 108:1903-10. 2006
    ..Platelet and VWF modulation by hydrodynamic force is a mechanism for activation-independent aggregation that may support thrombotic arterial occlusion...
  4. pmc Comparison of VerifyNow-P2Y12 test and Flow Cytometry for monitoring individual platelet response to clopidogrel. What is the cut-off value for identifying patients who are low responders to clopidogrel therapy?
    Cosmo Godino
    Department of Cardio Thoracic and Vascular Diseases, San Raffaele Scientific Institute, Milan, Italy
    Thromb J 7:4. 2009
    ..abstract:..
  5. ncbi request reprint Type IIB von Willebrand disease: a paradox explains how von Willebrand factor works
    Z M Ruggeri
    Roon Center for Arteriosclerosis and Thrombosis, Division of Experimental Hemostasis and Thrombosis, Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, CA 92037, USA
    J Thromb Haemost 2:2-6. 2004
    ..The net result is an apparent paradox, since the presence of a hyperfunctional adhesive molecule in blood causes a bleeding tendency. Here I recall how my colleagues and I managed to understand what goes on in these patients...
  6. ncbi request reprint Platelet and von Willebrand factor interactions at the vessel wall
    Z M Ruggeri
    Roon Center for Arteriosclerosis and Thrombosis, Division of Experimental Hemostasis and Thrombosis, Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, CA 92037, USA
    Hamostaseologie 24:1-11. 2004
    ....
  7. doi request reprint Unravelling the mechanism and significance of thrombin binding to platelet glycoprotein Ib
    Zaverio M Ruggeri
    Roon Research Center for Arteriosclerosis and Thrombosis, Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, California 92037, USA
    Thromb Haemost 104:894-902. 2010
    ..We review here published information on these topics and touch upon ongoing studies aimed at finding definitive answers to outstanding questions relevant for a better understanding of thrombosis and haemostasis...
  8. ncbi request reprint Platelet interactions with vessel wall components during thrombogenesis
    Zaverio M Ruggeri
    Roon Center for Arteriosclerosis and Thrombosis, Division of Experimental Hemostasis and Thrombosis, Department of Molecular and Experimental Medicine, The Scripps Research Institute MEM 175, La Jolla, CA 92037, USA
    Blood Cells Mol Dis 36:145-7. 2006
    ..We discuss the interrelationships of platelet glycoprotein receptors, von Willebrand factor, collagen, non-collagen matrix protein, and vascular cells in the complex events of platelet plug and subsequent thrombus formation...
  9. pmc The role of von Willebrand factor in thrombus formation
    Zaverio M Ruggeri
    The Scripps Research Institute, La Jolla, California, USA
    Thromb Res 120:S5-9. 2007
    ..This VWF-mediated process may be a key determinant of platelet accumulation in stenotic arteries leading to acute thrombotic occlusion...
  10. ncbi request reprint Adhesion mechanisms in platelet function
    Zaverio M Ruggeri
    The Roon Research Center for Arteriosclerosis and Thrombosis, Division of Blood Cell and Vascular Biology, Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, CA 92037, USA
    Circ Res 100:1673-85. 2007
    ....
  11. ncbi request reprint Von Willebrand factor: looking back and looking forward
    Zaverio M Ruggeri
    The Scripps Research Institute, MEM 175, 10550 N Torrey Pines Road, La Jolla, CA 92037, USA
    Thromb Haemost 98:55-62. 2007
    ..Many challenges remain, along with the hope of translating the knowledge acquired into new and efficacious treatments for arterial thrombosis...
  12. pmc Platelet adhesion under flow
    Zaverio M Ruggeri
    Roon Research Center for Arteriosclerosis and Thrombosis, Division of Blood Cell and Vascular Biology, Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, California 92037, USA
    Microcirculation 16:58-83. 2009
    ..The adaptation of platelet-adhesive functions to the effects of blood flow is the main focus of this review...
  13. ncbi request reprint Von Willebrand factor, platelets and endothelial cell interactions
    Z M Ruggeri
    Roon Research Laboratory for Arteriosclerosis and Thrombosis, Division of Experimental Thrombosis and Hemostasis, Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, California, USA
    J Thromb Haemost 1:1335-42. 2003
    ....
  14. ncbi request reprint Platelets in atherothrombosis
    Zaverio M Ruggeri
    Department of Molecular and Experimental Medicine The Scripps Research Institute, La Jolla, California, USA
    Nat Med 8:1227-34. 2002
  15. ncbi request reprint Contribution of distinct adhesive interactions to platelet aggregation in flowing blood
    Z M Ruggeri
    Roon Research Center for Arteriosclerosis and Thrombosis, The Division of Experimental Hemostasis and Thrombosis, The Department of Molecular and Experimental Medicine, Scripps Research Institute, La Jolla, CA 92037, USA
    Blood 94:172-8. 1999
    ..The specific function of distinct adhesion pathways in response to changing hemodynamic conditions helps to explain hemostatic and thrombotic processes...
  16. ncbi request reprint Structure and function of the von Willebrand factor A1 domain
    Kottayil I Varughese
    Roon Research Center for Arteriosclerosis and Thrombosis, Division of Experimental Hemostasis and Thrombosis, Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, California 92037, USA
    Curr Protein Pept Sci 3:301-12. 2002
    ..In this review, we present the current knowledge on the structural features of the VWF A1 domain that support its functions...
  17. ncbi request reprint Von Willebrand factor
    Zaverio M Ruggeri
    Room Research Laboratory for Arteriosclerosis and Thrombosis, Division of Experimental Hemostasis and Thrombosis, Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, California 92037, USA
    Curr Opin Hematol 10:142-9. 2003
    ..This progress in basic research has provided critical information to define with greater precision the role of von Willebrand factor in vascular biology and pathology...
  18. ncbi request reprint Role of von Willebrand factor in platelet thrombus formation
    Z M Ruggeri
    Roon Research Center for Arteriosclerosis and Thrombosis, Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, CA 92037, USA
    Ann Med 32:2-9. 2000
    ..Advances in understanding the structure and function of von Willebrand factor indicate that this protein, for its unique biomechanical properties, may be a potentially useful target of antithrombotic drugs...
  19. ncbi request reprint Mechanisms initiating platelet thrombus formation
    Z M Ruggeri
    Department of Molecular and Experimental Medicine, Scripps Research Institute, La Jolla, CA 92037, USA
    Thromb Haemost 78:611-6. 1997
    ....
  20. pmc Role for ADAP in shear flow-induced platelet mechanotransduction
    Ana Kasirer-Friede
    Department of Medicine, University of California San Diego, La Jolla, CA 92093 0726, USA
    Blood 115:2274-82. 2010
    ..These results establish that ADAP is an essential component of alphaIIbbeta3-mediated platelet mechanotransduction that promotes F-actin assembly and enables platelet spreading and thrombus stabilization under fluid shear stress...
  21. pmc Functional self-association of von Willebrand factor during platelet adhesion under flow
    Brian Savage
    Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 99:425-30. 2002
    ..The self-assembly of VWF multimers on an injured vascular surface may provide a relevant contribution to the arrest of flowing platelets opposing hemodynamic forces, thus facilitating subsequent thrombus growth...
  22. ncbi request reprint New perspectives on von Willebrand factor functions in hemostasis and thrombosis
    Grazia Loredana Mendolicchio
    Roon Research Laboratory for Arteriosclerosis and Thrombosis, Division of Experimental Thrombosis and Hemastasis, Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, CA 92037, USA
    Semin Hematol 42:5-14. 2005
    ..Developments in these areas of research will refine our understanding of the role played by VWF in vascular biology and pathology...
  23. pmc Size regulation of von Willebrand factor-mediated platelet thrombi by ADAMTS13 in flowing blood
    Roberta Donadelli
    Department of Molecular and Experimental Medicine, Division of Experimental Hemostasis and Thrombosis, Roon Center for Arteriosclerosis and Thrombosis, The Scripps Research Institute MEM 175, 10550 North Torrey Pines Rd, La Jolla, CA 92037, USA
    Blood 107:1943-50. 2006
    ..ADAMTS13, therefore, may regulate thrombus size preferentially when the cohesion between platelets depends on VWF binding induced by pathologically elevated shear stress...
  24. ncbi request reprint Lateral clustering of platelet GP Ib-IX complexes leads to up-regulation of the adhesive function of integrin alpha IIbbeta 3
    Ana Kasirer-Friede
    Departments of Cell Biology and Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, California 92037, USA
    J Biol Chem 277:11949-56. 2002
    ..By extrapolation, GP Ib-IX clustering in platelets may promote thrombus formation...
  25. ncbi request reprint Platinum-induced space-group transformation in crystals of the platelet glycoprotein Ib alpha N-terminal domain
    Kottayil I Varughese
    Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, CA 92037, USA
    Acta Crystallogr D Biol Crystallogr 60:405-11. 2004
    ..The tetragonal crystal structure was subsequently solved using molecular-replacement techniques using the monoclinic structure as the search model and was refined with 1.7 A resolution data...
  26. pmc The Modifier of hemostasis (Mh) locus on chromosome 4 controls in vivo hemostasis of Gp6-/- mice
    Yann Cheli
    Roon Research Center for Arteriosclerosis and Thrombosis, Division of Experimental Hemostasis and Thrombosis, Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, CA 92037, USA
    Blood 111:1266-73. 2008
    ..9, P < .0001) that we designate Modifier of hemostasis (Mh). Our results indicate that one or more modifier genes in Mh control the extent to which in vivo platelet thrombus formation is disrupted by the absence of platelet GPVI...
  27. ncbi request reprint Signaling through GP Ib-IX-V activates alpha IIb beta 3 independently of other receptors
    Ana Kasirer-Friede
    Department of Cell Biology, The Scripps Research Institute, 10550 N Torrey Pines Rd, La Jolla, CA 92037, USA
    Blood 103:3403-11. 2004
    ..These data establish that GP Ib-IX-V itself can signal to activate alpha IIb beta 3, through sequential actions of Src kinases, Ca(2+) oscillations, and PI 3-kinase/PKC...
  28. ncbi request reprint A single amino acid change in the binding pocket alters specificity of an anti-integrin antibody AP7.4 as revealed by its crystal structure
    Sona Vasudevan
    Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, CA 92037, USA
    Blood Cells Mol Dis 32:176-81. 2004
    ..Hence, the flexibility of the RGD-carrying loop observed in the crystal structure may stem from the fact that the antibody molecule mimics the function of these cell adhesion molecules...
  29. ncbi request reprint The contribution of glycoprotein VI to stable platelet adhesion and thrombus formation illustrated by targeted gene deletion
    Kazunobu Kato
    Roon Research Center for Arteriosclerosis and Thrombosis, Division of Experimental Hemostasis and Thrombosis, Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, CA, USA
    Blood 102:1701-7. 2003
    ..These results illustrate the role of GP VI in postadhesion events leading to the development of platelet thrombi on collagen fibrils...
  30. pmc Platelets prevent IFN-alpha/beta-induced lethal hemorrhage promoting CTL-dependent clearance of lymphocytic choriomeningitis virus
    Matteo Iannacone
    Department of Molecular and Experimental Medicine, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 105:629-34. 2008
    ....
  31. pmc Platelets mediate cytotoxic T lymphocyte-induced liver damage
    Matteo Iannacone
    Department of Molecular and Experimental Medicine, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, USA
    Nat Med 11:1167-9. 2005
    ..Thus, activated platelets contribute to CTL-mediated liver immunopathology independently of procoagulant function...
  32. pmc Hyperantithrombotic, noncytoprotective Glu149Ala-activated protein C mutant
    Laurent O Mosnier
    Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, CA 92037, USA
    Blood 113:5970-8. 2009
    ..Protein engineering can provide APC mutants that permit definitive mechanism of action studies for APC's multiple activities, and may also provide safer and more effective second-generation APC mutants with reduced bleeding risk...
  33. pmc HBV pathogenesis in animal models: recent advances on the role of platelets
    Matteo Iannacone
    Department of Molecular and Experimental Medicine, The Scripps Research Institute, 10550 N Torrey Pines Road, La Jolla, CA 92037, USA
    J Hepatol 46:719-26. 2007
    ....
  34. pmc Antiplatelet drug therapy moderates immune-mediated liver disease and inhibits viral clearance in mice infected with a replication-deficient adenovirus
    Matteo Iannacone
    Department of Molecular and Experimental Medicine, Scripps Research Institute, 10550 North Torrey Pines Rd, La Jolla, CA 92037, USA
    Clin Vaccine Immunol 14:1532-5. 2007
    ....
  35. ncbi request reprint Contribution of leptin receptor N-linked glycans to leptin binding
    Yuichi Kamikubo
    Roon Research Center for Arteriosclerosis and Thrombosis, Division of Blood Cell and Vascular Biology, Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, CA 92037, USA
    Biochem J 410:595-604. 2008
    ..Our findings show that N-linked glycans within Ig and/or FNIII domains regulate Ob-R function, but are not involved in essential interactions with the ligand...
  36. ncbi request reprint Tensile destruction test as an estimation of partial proteolysis in fibrin clots
    ENRIQUE SALDIVAR
    Roon Research Center for Arteriosclerosis and Thrombosis, Division of Experimental Hemostasis and Thrombosis, Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, California 92037, USA
    Am J Hematol 71:119-27. 2002
    ..Our findings suggest that when the fibers are cleaved their capacity to withstand stress is seriously challenged; thus, in principle, tensile destruction test can detect a minimal degree of proteolysis...
  37. ncbi request reprint Altered von Willebrand factor subunit proteolysis and multimer processing associated with the Cys2362Phe mutation in the B2 domain
    Alessandra Casonato
    Dept of Medical and Surgical Sciences, Via Ospedale Civile 105, Padova, Italy
    Thromb Haemost 97:527-33. 2007
    ..Our findings indicate that a proper conformation of the B2 domain, which depends on critical Cys residues, may be required for the normal proteolytic processing of vWF multimers...
  38. pmc Mechanism of platelet adhesion to von Willebrand factor and microparticle formation under high shear stress
    Armin J Reininger
    Department of Transfusion Medicine and Hemostaseology, University Clinic Munich, Ziemssenstr 1, 80336 Munich, Germany
    Blood 107:3537-45. 2006
    ....
  39. ncbi request reprint Sequential cytoplasmic calcium signals in a 2-stage platelet activation process induced by the glycoprotein Ibalpha mechanoreceptor
    Mario Mazzucato
    Servizio Immunotrasfusionale e Analisi Cliniche, Centro di Riferimento Oncologico, Aviano, Italy
    Blood 100:2793-800. 2002
    ..Our conclusions modify those proposed by others regarding the mechanisms that regulate signaling between GPIbalpha and alpha(IIb)beta(3) and lead to platelet adhesion and aggregation on immobilized VWF...
  40. ncbi request reprint The role of the porcine von Willebrand factor: baboon platelet interactions in pulmonary xenotransplantation
    Jeffrey G Gaca
    Department of Surgery, Duke University Medical Center, Durham, NC, USA
    Transplantation 74:1596-603. 2002
    ....
  41. ncbi request reprint A sensitive ristocetin co-factor activity assay with recombinant glycoprotein Ibalpha for the diagnosis of patients with low von Willebrand factor levels
    Augusto B Federici
    Angelo Bianchi Bonomi Hemophilia Thrombosis Center, Department of Internal Medicine and Dermatology, IRCCS Maggiore Hospital and University of Milan, Italy
    Haematologica 89:77-85. 2004
    ..A correct diagnosis of VWD relies on platelet agglutination tests that have a low accuracy within and between assays. A more accurate VWF:RCo assay would improve VWD diagnosis and classification...
  42. ncbi request reprint Induction of platelet thrombi by bacteria and antibodies
    Ulf Sjöbring
    Section for Microbiology, Immunology and Glycobiology, the Institute of Laboratory Medicine, University of Lund, Lund, Sweden
    Blood 100:4470-7. 2002
    ....
  43. ncbi request reprint Distinct roles of ADP receptors in von Willebrand factor-mediated platelet signaling and activation under high flow
    Mario Mazzucato
    Blood Bank, Centro di Riferimento Oncologico Istituto di Ricerca e Cura e Carattere Scientifico, National Cancer Institute, Aviano PN, Italy
    Blood 104:3221-7. 2004
    ....
  44. ncbi request reprint Factor XI interacts with the leucine-rich repeats of glycoprotein Ibalpha on the activated platelet
    Frank A Baglia
    Sol Sherry Thrombosis Research Center, Temple University School of Medicine, Philadelphia, Pennsylvania 19140, USA
    J Biol Chem 279:49323-9. 2004
    ..We conclude that FXI binds to glycoprotein Ibalpha at sites comprising the leucine-rich repeat sequences within the NH2-terminal globular domain that are separate and distinct from the thrombin-binding site...
  45. pmc The role of platelet adhesion receptor GPIbalpha far exceeds that of its main ligand, von Willebrand factor, in arterial thrombosis
    Wolfgang Bergmeier
    CBR Institute for Biomedical Research and Department of Pathology, Harvard Medical School, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 103:16900-5. 2006
    ..Thus, GPIbalpha contributes to arterial thrombosis by important adhesion mechanisms independent of the binding to VWF...
  46. ncbi request reprint Dependence of platelet thrombus stability on sustained glycoprotein IIb/IIIa activation through adenosine 5'-diphosphate receptor stimulation and cyclic calcium signaling
    Shinya Goto
    Department of Medicine, Tokai University School of Medicine, Kanagawa, Japan
    J Am Coll Cardiol 47:155-62. 2006
    ..We sought to evaluate the mechanisms that support the stability of platelet aggregates on a thrombogenic surface exposed to flowing blood...
  47. pmc Platelets and platelet adhesion support angiogenesis while preventing excessive hemorrhage
    Janka Kisucka
    CBR Institute for Biomedical Research, Department of Pathology, Harvard Medical School, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 103:855-60. 2006
    ..The adhesion function of platelets, as mediated by GPIbalpha, significantly contributes to the process...
  48. pmc A role of the fast ATP-gated P2X1 cation channel in thrombosis of small arteries in vivo
    Beatrice Hechler
    Institut National de la Santé et de la Recherche Médicale INSERM U 311, EFS Alsace 10, rue Spielmann, BP No 36, 67065 Strasbourg Cedex, France
    J Exp Med 198:661-7. 2003
    ..Overall, the P2X1 receptor appears to contribute to the formation of platelet thrombi, particularly in arteries in which shear forces are high...
  49. pmc ADAP is required for normal alphaIIbbeta3 activation by VWF/GP Ib-IX-V and other agonists
    Ana Kasirer-Friede
    Department of Medicine, University of California San Diego, La Jolla 92093 0726, USA
    Blood 109:1018-25. 2007
    ..These studies establish ADAP as a component of inside-out signaling pathways that couple GP Ib-IX-V and other platelet agonist receptors to alphaIIbbeta3 activation...
  50. pmc Eph kinases and ephrins support thrombus growth and stability by regulating integrin outside-in signaling in platelets
    Nicolas Prevost
    Department of Medicine, and Center for Experimental Therapeutics, University of Pennsylvania, 421 Curie Boulevard, Philadelphia, PA 19104, USA
    Proc Natl Acad Sci U S A 102:9820-5. 2005
    ....
  51. pmc Molecular bases of defective signal transduction in the platelet P2Y12 receptor of a patient with congenital bleeding
    Marco Cattaneo
    A Bianchi Bonomi Hemophilia and Thrombosis Center, Department of Internal Medicine, Istituto di Ricovero e Cura a Carattere Scientifico Ospedale Maggiore, University of Milan, 20122 Milan, Italy
    Proc Natl Acad Sci U S A 100:1978-83. 2003
    ..These studies delineate a region of P2Y(12) required for normal function after ADP binding...
  52. ncbi request reprint In-vitro and in-vivo consequences of mutations in the von Willebrand factor cleaving protease ADAMTS13 in thrombotic thrombocytopenic purpura
    Roberta Donadelli
    Mario Negri Institute for Pharmacological Research, Clinical Research Center for Rare Diseases, Villa Camozzi, Via Camozzi, 3, 24020 Ranica, Bergamo, Italy
    Thromb Haemost 96:454-64. 2006
    ..In conclusion, defective secretion and impaired activity of the mutants concur to determine an almost complete deficiency of ADAMTS13 activity in patients with a homozygous or two heterozygous ADAMTS13 mutations...
  53. pmc Laminin stimulates spreading of platelets through integrin alpha6beta1-dependent activation of GPVI
    Osamu Inoue
    Department of Clinical and Laboratory Medicine, Yamanashi Medical University, 1110 Shimokato Tamaho Nakakoma, Yamanashi 409 3898, Japan
    Blood 107:1405-12. 2006
    ..We speculate that laminin contributes to platelet spreading in vivo through a direct interaction with GPVI...

Research Grants12

  1. Role of von Willebrand Factor in Platelet Thrombus Formation
    Zaverio M Ruggeri; Fiscal Year: 2010
    ..Understanding these different functions requires addressing structural details as well as verification of concepts in intravidal models. This will lead to a better diagnosis and treatment for cardio- and cerebro-vascular diseases. ..
  2. Initiation and Regulation of Platelet Thrombus Formation
    ZAVERIO RUGGERI; Fiscal Year: 2004
    ..The results of the proposed studies will have an impact on public health by providing novel mechanistic information on processes that are central to normal hemostasis and pathological arterial thrombosis. ..
  3. Structure and function of platelet membrane glycoproteins
    Zaverio M Ruggeri; Fiscal Year: 2010
    ..This new knowledge may translate into improved diagnosis and treatment of common and serious diseases, thus enhancing human health. ..
  4. Thrombus Formation and Antithrombotic Intervention
    ZAVERIO RUGGERI; Fiscal Year: 2007
    ..abstract_text> ..
  5. Structure and function of platelet membrane glycoproteins
    ZAVERIO RUGGERI; Fiscal Year: 2007
    ..abstract_text> ..
  6. Mechanisms of Thrombus Instability
    ZAVERIO RUGGERI; Fiscal Year: 2007
    ..These studies will provide novel insights into the unexpected role of leptin in platelet function, and in the formation and stability of thrombi. ..
  7. Platelet interactions with vessel wall components
    ZAVERIO RUGGERI; Fiscal Year: 2005
    ..These findings will provide a better definition and characterization of several potential targets for antithrombotic intervention that may yield new treatments for patients at risk of cardiovascular and cerebrovascular events. ..
  8. Structure and function of platelet membrane glycoproteins
    Zaverio M Ruggeri; Fiscal Year: 2011
    ..This new knowledge may translate into improved diagnosis and treatment of common and serious diseases, thus enhancing human health. ..