Brad Rovin

Summary

Affiliation: The Ohio State University
Country: USA

Publications

  1. doi request reprint Efficacy and safety of rituximab in patients with active proliferative lupus nephritis: the Lupus Nephritis Assessment with Rituximab study
    Brad H Rovin
    Ohio State University, Columbus, OH 43210, USA
    Arthritis Rheum 64:1215-26. 2012
  2. pmc Mathematical framework for human SLE Nephritis: disease dynamics and urine biomarkers
    Paula Budu-Grajdeanu
    Department of Mathematics, Ohio State University, Columbus OH 43210, USA
    Theor Biol Med Model 7:14. 2010
  3. pmc Urinary TWEAK as a biomarker of lupus nephritis: a multicenter cohort study
    Noa Schwartz
    Division of Rheumatology, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, USA
    Arthritis Res Ther 11:R143. 2009
  4. pmc Flavopiridol administered using a pharmacologically derived schedule is associated with marked clinical efficacy in refractory, genetically high-risk chronic lymphocytic leukemia
    John C Byrd
    Division of Hematology Oncology, Department of Internal Medicine, The Ohio State University, Columbus, OH 43210, USA
    Blood 109:399-404. 2007
  5. pmc Random spot urine protein/creatinine ratio is unreliable for estimating 24-hour proteinuria in individual systemic lupus erythematosus nephritis patients
    Lee A Hebert
    Department of Internal Medicine, The Ohio State University, Columbus, Ohio 43210, USA
    Nephron Clin Pract 113:c177-82. 2009
  6. pmc Phase I clinical and pharmacokinetic study of a novel schedule of flavopiridol in relapsed or refractory acute leukemias
    William Blum
    Division of Hematology and Oncology and the Comprehensive Cancer Center, Department of Medicine, The Ohio State University, B310 Starling Loving Hall, 320 West 10 Avenue, Columbus, OH 43210, USA
    Haematologica 95:1098-105. 2010
  7. pmc Warfarin therapy that results in an International Normalization Ratio above the therapeutic range is associated with accelerated progression of chronic kidney disease
    Sergey V Brodsky
    Department of Pathology, The Ohio State University, Columbus, OH 43210, USA
    Nephron Clin Pract 115:c142-6. 2010
  8. pmc Oral cyclophosphamide is on the verge of extinction as therapy for severe autoimmune diseases (especially lupus): should nephrologists care?
    Lee A Hebert
    Department of Internal Medicine, The Ohio State University Medical Center, Columbus, Ohio 43210, USA
    Nephron Clin Pract 117:c8-14. 2011
  9. pmc A polymorphism in the type one complement receptor (CR1) involves an additional cysteine within the C3b/C4b binding domain that inhibits ligand binding
    Daniel J Birmingham
    Division of Nephrology, Department of Internal Medicine, The Davis Heart and Lung Research Institute, The Ohio State University, Columbus, OH 43210, United States
    Mol Immunol 44:3510-6. 2007
  10. ncbi request reprint The design of ALLHAT may have biased the study's outcome in favor of the diuretic cohort
    Lee A Hebert
    Ohio State University Medical Center, 1654 Upham Drive, Columbus, OH 43210, USA
    Nat Clin Pract Nephrol 3:60-1. 2007

Research Grants

Collaborators

Detail Information

Publications34

  1. doi request reprint Efficacy and safety of rituximab in patients with active proliferative lupus nephritis: the Lupus Nephritis Assessment with Rituximab study
    Brad H Rovin
    Ohio State University, Columbus, OH 43210, USA
    Arthritis Rheum 64:1215-26. 2012
    ..To evaluate the efficacy and safety of rituximab in a randomized, double-blind, placebo-controlled phase III trial in patients with lupus nephritis treated concomitantly with mycophenolate mofetil (MMF) and corticosteroids...
  2. pmc Mathematical framework for human SLE Nephritis: disease dynamics and urine biomarkers
    Paula Budu-Grajdeanu
    Department of Mathematics, Ohio State University, Columbus OH 43210, USA
    Theor Biol Med Model 7:14. 2010
    ..It has been postulated that biomarkers would be more informative if integrated into a pathogenic-based model of LN...
  3. pmc Urinary TWEAK as a biomarker of lupus nephritis: a multicenter cohort study
    Noa Schwartz
    Division of Rheumatology, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, USA
    Arthritis Res Ther 11:R143. 2009
    ..Evidence for the importance of TWEAK in the pathogenesis of lupus nephritis (LN) has been recently introduced. Thus, TWEAK levels may serve as an indication of LN presence and activity...
  4. pmc Flavopiridol administered using a pharmacologically derived schedule is associated with marked clinical efficacy in refractory, genetically high-risk chronic lymphocytic leukemia
    John C Byrd
    Division of Hematology Oncology, Department of Internal Medicine, The Ohio State University, Columbus, OH 43210, USA
    Blood 109:399-404. 2007
    ..Patients with bulky disease and high-risk genetic features have achieved durable responses, thereby justifying further study of flavopiridol in CLL and other diseases...
  5. pmc Random spot urine protein/creatinine ratio is unreliable for estimating 24-hour proteinuria in individual systemic lupus erythematosus nephritis patients
    Lee A Hebert
    Department of Internal Medicine, The Ohio State University, Columbus, Ohio 43210, USA
    Nephron Clin Pract 113:c177-82. 2009
    ..Shortly afterward, 2 works were published, designated Study 1 and Study 2, which are the only studies to test spot P/C in SLE GN. Here we evaluate Study 1 and Study 2, which came to different conclusions...
  6. pmc Phase I clinical and pharmacokinetic study of a novel schedule of flavopiridol in relapsed or refractory acute leukemias
    William Blum
    Division of Hematology and Oncology and the Comprehensive Cancer Center, Department of Medicine, The Ohio State University, B310 Starling Loving Hall, 320 West 10 Avenue, Columbus, OH 43210, USA
    Haematologica 95:1098-105. 2010
    ....
  7. pmc Warfarin therapy that results in an International Normalization Ratio above the therapeutic range is associated with accelerated progression of chronic kidney disease
    Sergey V Brodsky
    Department of Pathology, The Ohio State University, Columbus, OH 43210, USA
    Nephron Clin Pract 115:c142-6. 2010
    ..0 with formation of occlusive red blood casts. Recovery from this warfarin-associated AKI is poor. Here we investigated whether excessive warfarin therapy could accelerate the progression of CKD...
  8. pmc Oral cyclophosphamide is on the verge of extinction as therapy for severe autoimmune diseases (especially lupus): should nephrologists care?
    Lee A Hebert
    Department of Internal Medicine, The Ohio State University Medical Center, Columbus, Ohio 43210, USA
    Nephron Clin Pract 117:c8-14. 2011
    ..Here, we state the case for POCY as therapy for severe autoimmune diseases. We suggest that if POCY is allowed to compete, it will not disappoint...
  9. pmc A polymorphism in the type one complement receptor (CR1) involves an additional cysteine within the C3b/C4b binding domain that inhibits ligand binding
    Daniel J Birmingham
    Division of Nephrology, Department of Internal Medicine, The Davis Heart and Lung Research Institute, The Ohio State University, Columbus, OH 43210, United States
    Mol Immunol 44:3510-6. 2007
    ..The physiological role of this polymorphism remains to be determined...
  10. ncbi request reprint The design of ALLHAT may have biased the study's outcome in favor of the diuretic cohort
    Lee A Hebert
    Ohio State University Medical Center, 1654 Upham Drive, Columbus, OH 43210, USA
    Nat Clin Pract Nephrol 3:60-1. 2007
  11. ncbi request reprint Fluctuation in self-perceived stress and increased risk of flare in patients with lupus nephritis carrying the serotonin receptor 1A -1019 G allele
    Daniel J Birmingham
    Ohio State University, Columbus, OH 43210, USA
    Arthritis Rheum 54:3291-9. 2006
    ..The purpose of this study was to assess the relationship between self-perceived stress (SPS), variability in SPS, and the 2 serotonin-related gene polymorphisms as risk factors for SLE flare...
  12. pmc A dinucleotide deletion in CD24 confers protection against autoimmune diseases
    Lizhong Wang
    Division of Immunotherapy, Department of Surgery, Comprehensive Cancer Center, University of Michigan, Ann Arbor, Michigan, United States of America
    PLoS Genet 3:e49. 2007
    ..The dinucleotide deletion significantly reduced the stability of CD24 mRNA. Our results demonstrate that a destabilizing dinucleotide deletion in the 3' UTR of CD24 mRNA conveys significant protection against both MS and SLE...
  13. pmc Association of a common complement receptor 2 haplotype with increased risk of systemic lupus erythematosus
    Hui Wu
    Division of Rheumatology, University of California Los Angeles, 1000 Veteran Avenue, Los Angeles, CA 90095, USA
    Proc Natl Acad Sci U S A 104:3961-6. 2007
    ..Our findings reveal that CR2 is a likely susceptibility gene for human lupus at 1q32.2, extending previous studies suggesting that CR2 participates in the pathogenesis of systemic lupus erythematosus...
  14. pmc Gene copy-number variation and associated polymorphisms of complement component C4 in human systemic lupus erythematosus (SLE): low copy number is a risk factor for and high copy number is a protective factor against SLE susceptibility in European America
    Yan Yang
    Center for Molecular and Human Genetics, Columbus Children s Research Institute, Columbus, OH 43205, USA
    Am J Hum Genet 80:1037-54. 2007
    ..This work demonstrates how gene CNV and its related polymorphisms are associated with the susceptibility to a human complex disease...
  15. ncbi request reprint A novel interleukin-8 polymorphism is associated with severe systemic lupus erythematosus nephritis
    Brad H Rovin
    Nephrology Division, The Ohio State University School of Medicine and Public Health, N210 Means Hall, 1654 Upham Drive, Columbus, OH 43210, USA
    Kidney Int 62:261-5. 2002
    ..This study was undertaken to identify polymorphisms in the 5'-flanking region of the IL-8 gene that correlate with the severity of SLE nephritis...
  16. ncbi request reprint Urine chemokines as biomarkers of human systemic lupus erythematosus activity
    Brad H Rovin
    Ohio State University, Nephrology Division, N210 Means Hall, 1654 Upham Drive, Columbus, OH 43210, USA
    J Am Soc Nephrol 16:467-73. 2005
    ..Persistently elevated uMCP-1 after treatment may indicate ongoing kidney injury that may adversely affect renal prognosis...
  17. ncbi request reprint The influence of CCL3L1 gene-containing segmental duplications on HIV-1/AIDS susceptibility
    Enrique Gonzalez
    Veterans Administration Research Center for AIDS and HIV 1 Infection, South Texas Veterans Health Care System, and Department of Medicine, University of Texas Health Science Center, San Antonio, TX 78229, USA
    Science 307:1434-40. 2005
    ....
  18. pmc HIV-1 infection and AIDS dementia are influenced by a mutant MCP-1 allele linked to increased monocyte infiltration of tissues and MCP-1 levels
    Enrique Gonzalez
    Veterans Administration Research Center for AIDS and HIV 1 Infection and University of Texas Health Science Center, San Antonio, TX 78229, USA
    Proc Natl Acad Sci U S A 99:13795-800. 2002
    ..In a broader context, the MCP-1 -2578G allele may serve as a genetic determinant of outcome of other disease states in which MP-mediated tissue injury is central to disease pathogenesis...
  19. ncbi request reprint Association analysis of the R620W polymorphism of protein tyrosine phosphatase PTPN22 in systemic lupus erythematosus families: increased T allele frequency in systemic lupus erythematosus patients with autoimmune thyroid disease
    Hui Wu
    David Geffen School of Medicine, University of California, Los Angeles, 90095, USA
    Arthritis Rheum 52:2396-402. 2005
    ..We performed family-based association studies of this polymorphism in 4 independent cohorts containing SLE patients and their parents and/or other family members...
  20. ncbi request reprint PPAR-alpha ligands inhibit H2O2-mediated activation of transforming growth factor-beta1 in human mesangial cells
    William A Wilmer
    Division of Nephrology, The Department of Internal Medicine, Dorothy M Davis Heart Lung Research Institute, The Ohio State University College of Medicine, Columbus, OH 43210, USA
    Antioxid Redox Signal 4:877-84. 2002
    ..These studies are the first to identify PPAR-alpha expression by HMC. The results of these studies suggest that TGF-beta1 expression mediated by oxidant stress may be suppressible by PPAR-alpha activation...
  21. ncbi request reprint The expression of the cytomegalovirus chemokine receptor homolog US28 sequesters biologically active CC chemokines and alters IL-8 production
    Julie Randoph Randolph-Habecker
    Department of Pathology, The Ohio State University, Columbus, Ohio 43210, USA
    Cytokine 19:37-46. 2002
    ....
  22. ncbi request reprint Management of glomerular proteinuria: a commentary
    William A Wilmer
    Department of Internal Medicine, The Ohio State University Medical Center, Columbus, Ohio 43210 1250, USA
    J Am Soc Nephrol 14:3217-32. 2003
    ..This work is intended primarily for clinical nephrologists; therefore, each antiproteinuria intervention is described in practical detail...
  23. ncbi request reprint The intricate role of complement component C4 in human systemic lupus erythematosus
    Yan Yang
    Center for Molecular and Human Genetics, Columbus Children s Research Institute, Department of Molecular Virology, Immunology and Medical Genetics, Ohio State University, Columbus, Ohio, USA
    Curr Dir Autoimmun 7:98-132. 2004
    ..Likewise, elucidation of epistatic genetic factors interacting with C4AQ0 would provide important insights into the intricate roles of C4 in SLE disease susceptibility and pathogenesis...
  24. ncbi request reprint Mycophenolate therapy of SLE membranous nephropathy
    Dan N Spetie
    Department of Internal Medicine, Dorothy M Davis Heart and Lung Research Institute, The Ohio State University Medical Center, Columbus, Ohio, USA
    Kidney Int 66:2411-5. 2004
    ..Less is known about MMF treatment of membranous SLE GN (WHO Class V, SLE MN)...
  25. doi request reprint Systemic lupus international collaborating clinics renal activity/response exercise: development of a renal activity score and renal response index
    Michelle Petri
    Department of Rheumatology, Johns Hopkins University, Baltimore, Maryland 21205, USA
    Arthritis Rheum 58:1784-8. 2008
    ..To develop a measure of renal activity in systemic lupus erythematosus and use it to develop a renal response index...
  26. doi request reprint Systemic lupus international collaborating clinics renal activity/response exercise: comparison of agreement in rating renal response
    Michelle Petri
    Department of Rheumatology, Johns Hopkins University, Baltimore, Maryland 21205, USA
    Arthritis Rheum 58:1789-95. 2008
    ..To assess the degree to which physicians agree with each other and with ratings obtained with 3 existing responder indices, in rating the response to treatment of lupus nephritis...
  27. pmc Relationship between albuminuria and total proteinuria in systemic lupus erythematosus nephritis: diagnostic and therapeutic implications
    Daniel J Birmingham
    Department of Internal Medicine, Ohio State University Medical Center, Columbus, OH 43210 1250, USA
    Clin J Am Soc Nephrol 3:1028-33. 2008
    ....
  28. ncbi request reprint Diagnostic accuracy study of urine dipstick in relation to 24-hour measurement as a screening tool for proteinuria in lupus nephritis
    Mark J Siedner
    Columbia University College of Physicians and Surgeons, New York, NY, USA
    J Rheumatol 35:84-90. 2008
    ..We examined the validity of qualitative urine dipstick versus quantitative 24-hour measurement to accurately detect proteinuria, including low-level proteinuria...
  29. ncbi request reprint The chemokine network in systemic lupus erythematous nephritis
    Brad H Rovin
    The Ohio State University College of Medicine, Department of Internal Medicine, Division of Nephrology, N210 Means Hall, 1654 Upham Drive, Columbus, OH 43210, USA
    Front Biosci 13:904-22. 2008
    ..Anti-chemokine therapies hold the promise of efficacy with fewer adverse side-effects than the non-specific immunosuppression regimens currently in use...
  30. ncbi request reprint Biomarker discovery in human SLE nephritis
    Brad H Rovin
    Division of Nephrology, Ohio State University College of Medicine, and Columbus Children s Hospital Research Center 43210, USA
    Bull NYU Hosp Jt Dis 65:187-93. 2007
    ..The use of urine as a source of SLE nephritis biomarkers is described, and the results of urine biomarker discovery studies using candidate and proteomic approaches are presented...
  31. ncbi request reprint Cyclophosphamide or chlorambucil therapy is indicated in idiopathic membranous nephropathy with strong risk factors for progression
    Lee A Hebert
    Am J Kidney Dis 45:788-9; author replyy 789-90. 2005
  32. ncbi request reprint Clinical significance of fever in the systemic lupus erythematosus patient receiving steroid therapy
    Brad H Rovin
    Department of Internal Medicine, The Ohio State University, Columbus, Ohio 43210, USA
    Kidney Int 68:747-59. 2005
    ..Active systemic lupus erythematosus (SLE) can cause fever. Steroids (glucocorticoids) suppress SLE fever; however, the extent to which steroid therapy affects SLE fever not previously been rigorously studied...
  33. ncbi request reprint Plasma, urine, and renal expression of adiponectin in human systemic lupus erythematosus
    Brad H Rovin
    Department of Medicine and the Dorothy M Davis Heart and Lung Research Institute, Ohio State University College of Medicine and Public Health, Columbus, Ohio 43210, USA
    Kidney Int 68:1825-33. 2005
    ..A preliminary proteomic evaluation of urine for biomarkers of systemic lupus erythematosus (SLE) nephritis demonstrated high levels of adiponectin in SLE urine. This prompted investigation of adiponectin expression in human SLE...
  34. ncbi request reprint Three distinct profiles of serum complement C4 proteins in pediatric systemic lupus erythematosus (SLE) patients: tight associations of complement C4 and C3 protein levels in SLE but not in healthy subjects
    Yee Ling Wu
    Columbus Children s Research Institute, The Ohio State University, Columbus, Ohio 43205 USA
    Adv Exp Med Biol 586:227-47. 2006
    ..The third group had normal serum C4 levels (>15 mg/dL) most of the time and occasionally low C4 and C3 levels that were mostly coincident with disease flares prior to effective medical treatment. Most patients in this group..

Research Grants7

  1. CHEMOKINE REGULATION IN IMMUNE COMPLEX RENAL DISEASE
    Brad Rovin; Fiscal Year: 2001
    ..This information will likely suggest new directions for interventions to control renal inflammation. ..
  2. Proteomic and mRNA Profiling of Urine and Urine Sediment
    Brad Rovin; Fiscal Year: 2004
    ..abstract_text> ..
  3. Modeling SLE Nephritis Through Urine MCP-1
    Brad H Rovin; Fiscal Year: 2010
    ..In summary, this project is expected to demonstrate that uMCP-1 is a valid biomarker of lupus nephritis and its flare, and can be used to facilitate treatment decisions. ..