Research Topics
Species | Brad RovinSummaryAffiliation: The Ohio State University Country: USA Publications
Research Grants
| Collaborators
|
Detail Information
Publications
Efficacy and safety of rituximab in patients with active proliferative lupus nephritis: the Lupus Nephritis Assessment with Rituximab studyBrad H Rovin
Ohio State University, Columbus, OH 43210, USA
Arthritis Rheum 64:1215-26. 2012..To evaluate the efficacy and safety of rituximab in a randomized, double-blind, placebo-controlled phase III trial in patients with lupus nephritis treated concomitantly with mycophenolate mofetil (MMF) and corticosteroids...
Mathematical framework for human SLE Nephritis: disease dynamics and urine biomarkersPaula Budu-Grajdeanu
Department of Mathematics, Ohio State University, Columbus OH 43210, USA
Theor Biol Med Model 7:14. 2010..It has been postulated that biomarkers would be more informative if integrated into a pathogenic-based model of LN...- Urinary TWEAK as a biomarker of lupus nephritis: a multicenter cohort studyNoa Schwartz
Division of Rheumatology, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, USA
Arthritis Res Ther 11:R143. 2009..Evidence for the importance of TWEAK in the pathogenesis of lupus nephritis (LN) has been recently introduced. Thus, TWEAK levels may serve as an indication of LN presence and activity... - Flavopiridol administered using a pharmacologically derived schedule is associated with marked clinical efficacy in refractory, genetically high-risk chronic lymphocytic leukemiaJohn C Byrd
Division of Hematology Oncology, Department of Internal Medicine, The Ohio State University, Columbus, OH 43210, USA
Blood 109:399-404. 2007..Patients with bulky disease and high-risk genetic features have achieved durable responses, thereby justifying further study of flavopiridol in CLL and other diseases... - Random spot urine protein/creatinine ratio is unreliable for estimating 24-hour proteinuria in individual systemic lupus erythematosus nephritis patientsLee A Hebert
Department of Internal Medicine, The Ohio State University, Columbus, Ohio 43210, USA
Nephron Clin Pract 113:c177-82. 2009..Shortly afterward, 2 works were published, designated Study 1 and Study 2, which are the only studies to test spot P/C in SLE GN. Here we evaluate Study 1 and Study 2, which came to different conclusions... - Phase I clinical and pharmacokinetic study of a novel schedule of flavopiridol in relapsed or refractory acute leukemiasWilliam Blum
Division of Hematology and Oncology and the Comprehensive Cancer Center, Department of Medicine, The Ohio State University, B310 Starling Loving Hall, 320 West 10 Avenue, Columbus, OH 43210, USA
Haematologica 95:1098-105. 2010.... - Warfarin therapy that results in an International Normalization Ratio above the therapeutic range is associated with accelerated progression of chronic kidney diseaseSergey V Brodsky
Department of Pathology, The Ohio State University, Columbus, OH 43210, USA
Nephron Clin Pract 115:c142-6. 2010..0 with formation of occlusive red blood casts. Recovery from this warfarin-associated AKI is poor. Here we investigated whether excessive warfarin therapy could accelerate the progression of CKD... - Oral cyclophosphamide is on the verge of extinction as therapy for severe autoimmune diseases (especially lupus): should nephrologists care?Lee A Hebert
Department of Internal Medicine, The Ohio State University Medical Center, Columbus, Ohio 43210, USA
Nephron Clin Pract 117:c8-14. 2011..Here, we state the case for POCY as therapy for severe autoimmune diseases. We suggest that if POCY is allowed to compete, it will not disappoint... - A polymorphism in the type one complement receptor (CR1) involves an additional cysteine within the C3b/C4b binding domain that inhibits ligand bindingDaniel J Birmingham
Division of Nephrology, Department of Internal Medicine, The Davis Heart and Lung Research Institute, The Ohio State University, Columbus, OH 43210, United States
Mol Immunol 44:3510-6. 2007..The physiological role of this polymorphism remains to be determined... 
The design of ALLHAT may have biased the study's outcome in favor of the diuretic cohortLee A Hebert
Ohio State University Medical Center, 1654 Upham Drive, Columbus, OH 43210, USA
Nat Clin Pract Nephrol 3:60-1. 2007- Fluctuation in self-perceived stress and increased risk of flare in patients with lupus nephritis carrying the serotonin receptor 1A -1019 G alleleDaniel J Birmingham
Ohio State University, Columbus, OH 43210, USA
Arthritis Rheum 54:3291-9. 2006..The purpose of this study was to assess the relationship between self-perceived stress (SPS), variability in SPS, and the 2 serotonin-related gene polymorphisms as risk factors for SLE flare... - A dinucleotide deletion in CD24 confers protection against autoimmune diseasesLizhong Wang
Division of Immunotherapy, Department of Surgery, Comprehensive Cancer Center, University of Michigan, Ann Arbor, Michigan, United States of America
PLoS Genet 3:e49. 2007..The dinucleotide deletion significantly reduced the stability of CD24 mRNA. Our results demonstrate that a destabilizing dinucleotide deletion in the 3' UTR of CD24 mRNA conveys significant protection against both MS and SLE... - Association of a common complement receptor 2 haplotype with increased risk of systemic lupus erythematosusHui Wu
Division of Rheumatology, University of California Los Angeles, 1000 Veteran Avenue, Los Angeles, CA 90095, USA
Proc Natl Acad Sci U S A 104:3961-6. 2007..Our findings reveal that CR2 is a likely susceptibility gene for human lupus at 1q32.2, extending previous studies suggesting that CR2 participates in the pathogenesis of systemic lupus erythematosus... - Gene copy-number variation and associated polymorphisms of complement component C4 in human systemic lupus erythematosus (SLE): low copy number is a risk factor for and high copy number is a protective factor against SLE susceptibility in European AmericaYan Yang
Center for Molecular and Human Genetics, Columbus Children s Research Institute, Columbus, OH 43205, USA
Am J Hum Genet 80:1037-54. 2007..This work demonstrates how gene CNV and its related polymorphisms are associated with the susceptibility to a human complex disease... - A novel interleukin-8 polymorphism is associated with severe systemic lupus erythematosus nephritisBrad H Rovin
Nephrology Division, The Ohio State University School of Medicine and Public Health, N210 Means Hall, 1654 Upham Drive, Columbus, OH 43210, USA
Kidney Int 62:261-5. 2002..This study was undertaken to identify polymorphisms in the 5'-flanking region of the IL-8 gene that correlate with the severity of SLE nephritis... - Urine chemokines as biomarkers of human systemic lupus erythematosus activityBrad H Rovin
Ohio State University, Nephrology Division, N210 Means Hall, 1654 Upham Drive, Columbus, OH 43210, USA
J Am Soc Nephrol 16:467-73. 2005..Persistently elevated uMCP-1 after treatment may indicate ongoing kidney injury that may adversely affect renal prognosis... - The influence of CCL3L1 gene-containing segmental duplications on HIV-1/AIDS susceptibilityEnrique Gonzalez
Veterans Administration Research Center for AIDS and HIV 1 Infection, South Texas Veterans Health Care System, and Department of Medicine, University of Texas Health Science Center, San Antonio, TX 78229, USA
Science 307:1434-40. 2005.... - HIV-1 infection and AIDS dementia are influenced by a mutant MCP-1 allele linked to increased monocyte infiltration of tissues and MCP-1 levelsEnrique Gonzalez
Veterans Administration Research Center for AIDS and HIV 1 Infection and University of Texas Health Science Center, San Antonio, TX 78229, USA
Proc Natl Acad Sci U S A 99:13795-800. 2002..In a broader context, the MCP-1 -2578G allele may serve as a genetic determinant of outcome of other disease states in which MP-mediated tissue injury is central to disease pathogenesis... - Association analysis of the R620W polymorphism of protein tyrosine phosphatase PTPN22 in systemic lupus erythematosus families: increased T allele frequency in systemic lupus erythematosus patients with autoimmune thyroid diseaseHui Wu
David Geffen School of Medicine, University of California, Los Angeles, 90095, USA
Arthritis Rheum 52:2396-402. 2005..We performed family-based association studies of this polymorphism in 4 independent cohorts containing SLE patients and their parents and/or other family members... - PPAR-alpha ligands inhibit H2O2-mediated activation of transforming growth factor-beta1 in human mesangial cellsWilliam A Wilmer
Division of Nephrology, The Department of Internal Medicine, Dorothy M Davis Heart Lung Research Institute, The Ohio State University College of Medicine, Columbus, OH 43210, USA
Antioxid Redox Signal 4:877-84. 2002..These studies are the first to identify PPAR-alpha expression by HMC. The results of these studies suggest that TGF-beta1 expression mediated by oxidant stress may be suppressible by PPAR-alpha activation... - The expression of the cytomegalovirus chemokine receptor homolog US28 sequesters biologically active CC chemokines and alters IL-8 productionJulie-Randoph Randolph-Habecker
Department of Pathology, The Ohio State University, Columbus, Ohio 43210, USA
Cytokine 19:37-46. 2002.... - Management of glomerular proteinuria: a commentaryWilliam A Wilmer
Department of Internal Medicine, The Ohio State University Medical Center, Columbus, Ohio 43210 1250, USA
J Am Soc Nephrol 14:3217-32. 2003..This work is intended primarily for clinical nephrologists; therefore, each antiproteinuria intervention is described in practical detail... - The intricate role of complement component C4 in human systemic lupus erythematosusYan Yang
Center for Molecular and Human Genetics, Columbus Children's Research Institute, Department of Molecular Virology, Immunology and Medical Genetics, Ohio State University, Columbus, Ohio, USA
Curr Dir Autoimmun 7:98-132. 2004..Likewise, elucidation of epistatic genetic factors interacting with C4AQ0 would provide important insights into the intricate roles of C4 in SLE disease susceptibility and pathogenesis... - Mycophenolate therapy of SLE membranous nephropathyDan N Spetie
Department of Internal Medicine, Dorothy M. Davis Heart and Lung Research Institute, The Ohio State University Medical Center, Columbus, Ohio, USA
Kidney Int 66:2411-5. 2004..CONCLUSION: These promising results suggest that moderate dose MMF in combination with renoprotective/antiproteinuria therapy warrants further study in the management of SLE MN... - Systemic lupus international collaborating clinics renal activity/response exercise: development of a renal activity score and renal response indexMichelle Petri
Department of Rheumatology, Johns Hopkins University, Baltimore, Maryland 21205, USA
Arthritis Rheum 58:1784-8. 2008..To develop a measure of renal activity in systemic lupus erythematosus and use it to develop a renal response index... - Systemic lupus international collaborating clinics renal activity/response exercise: comparison of agreement in rating renal responseMichelle Petri
Department of Rheumatology, Johns Hopkins University, Baltimore, Maryland 21205, USA
Arthritis Rheum 58:1789-95. 2008..To assess the degree to which physicians agree with each other and with ratings obtained with 3 existing responder indices, in rating the response to treatment of lupus nephritis... - Relationship between albuminuria and total proteinuria in systemic lupus erythematosus nephritis: diagnostic and therapeutic implicationsDaniel J Birmingham
Department of Internal Medicine, Ohio State University Medical Center, Columbus, OH 43210 1250, USA
Clin J Am Soc Nephrol 3:1028-33. 2008.... - Diagnostic accuracy study of urine dipstick in relation to 24-hour measurement as a screening tool for proteinuria in lupus nephritisMark J Siedner
Columbia University College of Physicians and Surgeons, New York, NY, USA
J Rheumatol 35:84-90. 2008..We examined the validity of qualitative urine dipstick versus quantitative 24-hour measurement to accurately detect proteinuria, including low-level proteinuria... - The chemokine network in systemic lupus erythematous nephritisBrad H Rovin
The Ohio State University College of Medicine, Department of Internal Medicine, Division of Nephrology, N210 Means Hall, 1654 Upham Drive, Columbus, OH 43210, USA
Front Biosci 13:904-22. 2008..Anti-chemokine therapies hold the promise of efficacy with fewer adverse side-effects than the non-specific immunosuppression regimens currently in use... - Biomarker discovery in human SLE nephritisBrad H Rovin
Division of Nephrology, Ohio State University College of Medicine, and Columbus Children s Hospital Research Center 43210, USA
Bull NYU Hosp Jt Dis 65:187-93. 2007..The use of urine as a source of SLE nephritis biomarkers is described, and the results of urine biomarker discovery studies using candidate and proteomic approaches are presented... - Cyclophosphamide or chlorambucil therapy is indicated in idiopathic membranous nephropathy with strong risk factors for progressionLee A Hebert
Am J Kidney Dis 45:788-9; author replyy 789-90. 2005 - Clinical significance of fever in the systemic lupus erythematosus patient receiving steroid therapyBrad H Rovin
Department of Internal Medicine, The Ohio State University, Columbus, Ohio 43210, USA
Kidney Int 68:747-59. 2005..When fever does develop, it is usually due to infection. Continuing high steroid dose steroid therapy in those with infection fever may increase the risk of severe sepsis... - Plasma, urine, and renal expression of adiponectin in human systemic lupus erythematosusBrad H Rovin
Department of Medicine and the Dorothy M Davis Heart and Lung Research Institute, Ohio State University College of Medicine and Public Health, Columbus, Ohio 43210, USA
Kidney Int 68:1825-33. 2005..A preliminary proteomic evaluation of urine for biomarkers of systemic lupus erythematosus (SLE) nephritis demonstrated high levels of adiponectin in SLE urine. This prompted investigation of adiponectin expression in human SLE... - Three distinct profiles of serum complement C4 proteins in pediatric systemic lupus erythematosus (SLE) patients: tight associations of complement C4 and C3 protein levels in SLE but not in healthy subjectsYee Ling Wu
Columbus Children s Research Institute, The Ohio State University, Columbus, Ohio 43205 USA
Adv Exp Med Biol 586:227-47. 2006..The third group had normal serum C4 levels (>15 mg/dL) most of the time and occasionally low C4 and C3 levels that were mostly coincident with disease flares prior to effective medical treatment. Most patients in this group..
Research Grants
- CHEMOKINE REGULATION IN IMMUNE COMPLEX RENAL DISEASEBrad Rovin; Fiscal Year: 2001..This information will likely suggest new directions for interventions to control renal inflammation. ..
- Proteomic and mRNA Profiling of Urine and Urine SedimentBrad Rovin; Fiscal Year: 2004..abstract_text> ..
- Modeling SLE Nephritis Through Urine MCP-1Brad H Rovin; Fiscal Year: 2010..In summary, this project is expected to demonstrate that uMCP-1 is a valid biomarker of lupus nephritis and its flare, and can be used to facilitate treatment decisions. ..