B H Rovin

Summary

Affiliation: The Ohio State University
Country: USA

Publications

  1. pmc Characterization of glomerular diseases using proteomic analysis of laser capture microdissected glomeruli
    Anjali A Satoskar
    Department of Pathology, The Ohio State University Medical Center, Columbus, OH, USA
    Mod Pathol 25:709-21. 2012
  2. ncbi request reprint Lupus nephritis: the evolving role of novel therapeutics
    Brad H Rovin
    Division of Nephrology, Ohio State University Wexner Medical Center, Columbus, OH Electronic address
    Am J Kidney Dis 63:677-90. 2014
  3. doi request reprint Lupus nephritis: induction therapy in severe lupus nephritis--should MMF be considered the drug of choice?
    Brad H Rovin
    Department of Medicine, Ohio State University Wexner Medical Center, Columbus, OH 43210, USA
    Clin J Am Soc Nephrol 8:147-53. 2013
  4. ncbi request reprint 15-Deoxy-Delta12,14-prostaglandin J2 regulates mesangial cell proliferation and death
    Brad H Rovin
    Department of Internal Medicine and Heart Lung Research Institute, Ohio State University School of Medicine and Public Health, Columbus, Ohio 43210, USA
    Kidney Int 61:1293-302. 2002
  5. doi request reprint Biomarkers for lupus nephritis: the quest continues
    Brad H Rovin
    Division of Nephrology, Ohio State University College of Medicine, 395 W 12th Avenue, Ground Floor, Columbus, OH 43210, USA
    Clin J Am Soc Nephrol 4:1858-65. 2009
  6. ncbi request reprint Chemokine induction by the adipocyte-derived cytokine adiponectin
    Brad H Rovin
    The Ohio State University College of Medicine and Public Health, Columbus, OH 43210, USA
    Clin Immunol 120:99-105. 2006
  7. ncbi request reprint The chemokine network in systemic lupus erythematous nephritis
    Brad H Rovin
    The Ohio State University College of Medicine, Department of Internal Medicine, Division of Nephrology, N210 Means Hall, 1654 Upham Drive, Columbus, OH 43210, USA
    Front Biosci 13:904-22. 2008
  8. ncbi request reprint A novel interleukin-8 polymorphism is associated with severe systemic lupus erythematosus nephritis
    Brad H Rovin
    Nephrology Division, The Ohio State University School of Medicine and Public Health, N210 Means Hall, 1654 Upham Drive, Columbus, OH 43210, USA
    Kidney Int 62:261-5. 2002
  9. doi request reprint Can we personalize treatment for kidney diseases?
    Brad H Rovin
    Division of Nephrology, Department of Internal Medicine, Ohio State University College of Medicine, Columbus 43210, OH 43210, USA
    Clin J Am Soc Nephrol 4:1670-6. 2009
  10. ncbi request reprint Chemotactic factors and renal inflammation
    B H Rovin
    Department of Medicine, The Ohio State University College of Medicine and Public Health, Columbus, USA
    Am J Kidney Dis 31:1065-84. 1998

Detail Information

Publications67

  1. pmc Characterization of glomerular diseases using proteomic analysis of laser capture microdissected glomeruli
    Anjali A Satoskar
    Department of Pathology, The Ohio State University Medical Center, Columbus, OH, USA
    Mod Pathol 25:709-21. 2012
    ..This study demonstrates that our method acquires reproducible and quantitative proteomic information from laser capture microdissection isolates that can be used to characterize the molecular features of glomerular diseases...
  2. ncbi request reprint Lupus nephritis: the evolving role of novel therapeutics
    Brad H Rovin
    Division of Nephrology, Ohio State University Wexner Medical Center, Columbus, OH Electronic address
    Am J Kidney Dis 63:677-90. 2014
    ..In this review, we discuss novel lupus nephritis therapies and how they fit into a combinatorial treatment strategy based on the pathogenic stage. ..
  3. doi request reprint Lupus nephritis: induction therapy in severe lupus nephritis--should MMF be considered the drug of choice?
    Brad H Rovin
    Department of Medicine, Ohio State University Wexner Medical Center, Columbus, OH 43210, USA
    Clin J Am Soc Nephrol 8:147-53. 2013
    ..Therefore, mycophenolate mofetil should not yet be considered the induction drug of choice for severe lupus nephritis...
  4. ncbi request reprint 15-Deoxy-Delta12,14-prostaglandin J2 regulates mesangial cell proliferation and death
    Brad H Rovin
    Department of Internal Medicine and Heart Lung Research Institute, Ohio State University School of Medicine and Public Health, Columbus, Ohio 43210, USA
    Kidney Int 61:1293-302. 2002
    ..To identify endogenous factors that may be responsible for regulating glomerular cell number, the effects of J-series cyclopentenone prostaglandins (PGs) on human glomerular mesangial cell proliferation and death were examined...
  5. doi request reprint Biomarkers for lupus nephritis: the quest continues
    Brad H Rovin
    Division of Nephrology, Ohio State University College of Medicine, 395 W 12th Avenue, Ground Floor, Columbus, OH 43210, USA
    Clin J Am Soc Nephrol 4:1858-65. 2009
    ..This article reviews the current status of lupus nephritis biomarker investigation and articulates a perspective of how future efforts should be focused...
  6. ncbi request reprint Chemokine induction by the adipocyte-derived cytokine adiponectin
    Brad H Rovin
    The Ohio State University College of Medicine and Public Health, Columbus, OH 43210, USA
    Clin Immunol 120:99-105. 2006
    ..We conclude that adiponectin may have pro- and anti-inflammatory effects, and its exact role in specific inflammatory diseases remains to be worked out...
  7. ncbi request reprint The chemokine network in systemic lupus erythematous nephritis
    Brad H Rovin
    The Ohio State University College of Medicine, Department of Internal Medicine, Division of Nephrology, N210 Means Hall, 1654 Upham Drive, Columbus, OH 43210, USA
    Front Biosci 13:904-22. 2008
    ..Anti-chemokine therapies hold the promise of efficacy with fewer adverse side-effects than the non-specific immunosuppression regimens currently in use...
  8. ncbi request reprint A novel interleukin-8 polymorphism is associated with severe systemic lupus erythematosus nephritis
    Brad H Rovin
    Nephrology Division, The Ohio State University School of Medicine and Public Health, N210 Means Hall, 1654 Upham Drive, Columbus, OH 43210, USA
    Kidney Int 62:261-5. 2002
    ..This study was undertaken to identify polymorphisms in the 5'-flanking region of the IL-8 gene that correlate with the severity of SLE nephritis...
  9. doi request reprint Can we personalize treatment for kidney diseases?
    Brad H Rovin
    Division of Nephrology, Department of Internal Medicine, Ohio State University College of Medicine, Columbus 43210, OH 43210, USA
    Clin J Am Soc Nephrol 4:1670-6. 2009
    ..The goal of this review is to demonstrate that we can personalize therapy for kidney diseases but that considerable investment in new research will be required for personalized medicine to be routinely used in nephrology clinics...
  10. ncbi request reprint Chemotactic factors and renal inflammation
    B H Rovin
    Department of Medicine, The Ohio State University College of Medicine and Public Health, Columbus, USA
    Am J Kidney Dis 31:1065-84. 1998
    ....
  11. ncbi request reprint A novel polymorphism in the MCP-1 gene regulatory region that influences MCP-1 expression
    B H Rovin
    Department of Medicine, Ohio State University School of Medicine and Public Health, Columbus, Ohio 43210, USA
    Biochem Biophys Res Commun 259:344-8. 1999
    ..These data identify a polymorphism in the MCP-1 distal regulatory region that affects the level of MCP-1 expression in response to an inflammatory stimulus...
  12. ncbi request reprint Chemokine blockade as a therapy for renal disease
    B H Rovin
    Department of Medicine, Ohio State University School of Medicine and Public Health, Columbus, USA
    Curr Opin Nephrol Hypertens 9:225-32. 2000
    ..Effective use of anti-chemokine therapy for renal disease will require a precise understanding of the unique roles that individual chemokines have in renal pathology, and the genetic factors that regulate chemokine expression...
  13. ncbi request reprint Biomarker discovery in human SLE nephritis
    Brad H Rovin
    Division of Nephrology, Ohio State University College of Medicine, and Columbus Children s Hospital Research Center 43210, USA
    Bull NYU Hosp Jt Dis 65:187-93. 2007
    ..The use of urine as a source of SLE nephritis biomarkers is described, and the results of urine biomarker discovery studies using candidate and proteomic approaches are presented...
  14. ncbi request reprint Lymphocytes induce monocyte chemoattractant protein-1 production by renal cells after Fc gamma receptor cross-linking: role of IL-1beta
    B H Rovin
    Department of Internal Medicine and the Heart Lung Research Institute, The Ohio State University School of Medicine and Public Health, USA
    J Leukoc Biol 69:435-9. 2001
    ..Renal chemokine expression in immune complex disease may thus be triggered as lymphocytes traffic through the kidney and encounter deposited immune complexes...
  15. ncbi request reprint Cyclopentenone prostaglandins inhibit cytokine-induced nf-kappab activation and chemokine production by human mesangial cells
    B H Rovin
    Nephrology Division, Department of Internal Medicine, The Ohio State University, 1654 Upham Drive, Columbus, OH 43210 1250, USA
    J Am Soc Nephrol 12:1659-67. 2001
    ..These data suggest that certain prostaglandins can limit the extent of renal chemokine expression and thus may have an important role in resolving renal inflammation...
  16. pmc Evidence that abnormally large seasonal declines in vitamin D status may trigger SLE flare in non-African Americans
    D J Birmingham
    Department of Medicine and Davis Heart and Lung Research Institute, Ohio State University Medical Center, Columbus, OH 43210, USA
    Lupus 21:855-64. 2012
    ..028). In conclusion, in non-AA SLE patients, unusually large declines in 25(OH)D during LDM may be mechanistically related to SLE flare, whereas relatively high 25(OH)D levels during HDM may protect against flare...
  17. pmc The complex nature of serum C3 and C4 as biomarkers of lupus renal flare
    D J Birmingham
    The Ohio State University, Columbus, OH 43210, USA
    Lupus 19:1272-80. 2010
    ....
  18. ncbi request reprint Of mice and men: the relevance of the mouse to the study of human SLE
    D J Birmingham
    The Department of Internal Medicine, The Heart Lung Research Institute, The Ohio State University, Columbus, USA
    Immunol Res 24:211-24. 2001
    ..Thus, generalizing the results of the mouse studies to human SLE and other human IC diseases must be done with caution...
  19. ncbi request reprint Lymphocytes produce IL-1beta in response to Fcgamma receptor cross-linking: effects on parenchymal cell IL-8 release
    C B Marsh
    Division of Pulmonary and Critical Care Medicine, Ohio State University, Columbus 43210, USA
    J Immunol 160:3942-8. 1998
    ..These data suggest that targeted deposits of IgG can stimulate FcgammaRIII-bearing lymphocytes to produce IL-1beta, which induces parenchymal cell IL-8 release...
  20. pmc Oral cyclophosphamide for lupus glomerulonephritis: an underused therapeutic option
    Alison McKinley
    Department of Internal Medicine, Divisions of Nephrology, Ohio State University, Columbus, Ohio 43210, USA
    Clin J Am Soc Nephrol 4:1754-60. 2009
    ..Our experience with POCY suggests that it is well tolerated and consistently associated with good long-term outcomes. Here we report this experience to build a case for maintaining POCY as a therapeutic option in lupus nephritis...
  21. pmc Gene copy-number variation and associated polymorphisms of complement component C4 in human systemic lupus erythematosus (SLE): low copy number is a risk factor for and high copy number is a protective factor against SLE susceptibility in European America
    Yan Yang
    Center for Molecular and Human Genetics, Columbus Children s Research Institute, Columbus, OH 43205, USA
    Am J Hum Genet 80:1037-54. 2007
    ..This work demonstrates how gene CNV and its related polymorphisms are associated with the susceptibility to a human complex disease...
  22. pmc Phenotypes, genotypes and disease susceptibility associated with gene copy number variations: complement C4 CNVs in European American healthy subjects and those with systemic lupus erythematosus
    Y L Wu
    Center for Molecular and Human Genetics, The Research Institute at Nationwide Children s Research Institute, Columbus, OH, USA
    Cytogenet Genome Res 123:131-41. 2008
    ..Therefore, it is concluded that lower copy number of C4 is a risk factor for and higher gene copy number of C4 is a protective factor against SLE disease susceptibility...
  23. ncbi request reprint Spot urine protein/creatinine ratios are unreliable estimates of 24 h proteinuria in most systemic lupus erythematosus nephritis flares
    D J Birmingham
    Department of Internal Medicine, The Ohio State University, Columbus, Ohio 43220, USA
    Kidney Int 72:865-70. 2007
    ..Our work suggests that the use of spot urine P/C ratios will yield more false-positive and -negative diagnoses of glomerulonephritis flares in patients with SLE than the ratio in 24-h urines...
  24. pmc Biomarkers of lupus nephritis determined by serial urine proteomics
    Xiaolan Zhang
    1Department of Internal Medicine, Ohio State University, Columbus, Ohio, USA
    Kidney Int 74:799-807. 2008
    ..These studies provide a beginning proteomic analysis aimed at predicting impending renal relapse, relapse severity, and the potential for recovery after SLE nephritis flare...
  25. ncbi request reprint Urine chemokines as biomarkers of human systemic lupus erythematosus activity
    Brad H Rovin
    Ohio State University, Nephrology Division, N210 Means Hall, 1654 Upham Drive, Columbus, OH 43210, USA
    J Am Soc Nephrol 16:467-73. 2005
    ..Persistently elevated uMCP-1 after treatment may indicate ongoing kidney injury that may adversely affect renal prognosis...
  26. ncbi request reprint Plasma, urine, and renal expression of adiponectin in human systemic lupus erythematosus
    Brad H Rovin
    Department of Medicine and the Dorothy M Davis Heart and Lung Research Institute, Ohio State University College of Medicine and Public Health, Columbus, Ohio 43210, USA
    Kidney Int 68:1825-33. 2005
    ..A preliminary proteomic evaluation of urine for biomarkers of systemic lupus erythematosus (SLE) nephritis demonstrated high levels of adiponectin in SLE urine. This prompted investigation of adiponectin expression in human SLE...
  27. ncbi request reprint Management of glomerular proteinuria: a commentary
    William A Wilmer
    Department of Internal Medicine, The Ohio State University Medical Center, Columbus, Ohio 43210 1250, USA
    J Am Soc Nephrol 14:3217-32. 2003
    ..This work is intended primarily for clinical nephrologists; therefore, each antiproteinuria intervention is described in practical detail...
  28. pmc A mathematical model of venous neointimal hyperplasia formation
    Paula Budu-Grajdeanu
    Mathematical Biosciences Institute, The Ohio State University, Columbus, OH, USA
    Theor Biol Med Model 5:2. 2008
    ..The release of growth factors due to surgical injury, oxidative stress and turbulent flow has been suggested as a possible mechanism for neointimal hyperplasia...
  29. ncbi request reprint Stress protein activation by the cyclopentenone prostaglandin 15-deoxy-delta12,14-prostaglandin J2 in human mesangial cells
    Xiaolan Zhang
    Department of Medicine and the Dorothy M Davis Heart and Lung Institute, The Ohio State University College of Medicine and Public Health, Columbus, Ohio 43210, USA
    Kidney Int 65:798-810. 2004
    ..Because cyclopentenone prostaglandins are highly reactive toward intracellular thiols, the role of intracellular thiol modification in the stress response to 15dPGJ2 was examined...
  30. ncbi request reprint The expression of the cytomegalovirus chemokine receptor homolog US28 sequesters biologically active CC chemokines and alters IL-8 production
    Julie Randoph Randolph-Habecker
    Department of Pathology, The Ohio State University, Columbus, Ohio 43210, USA
    Cytokine 19:37-46. 2002
    ....
  31. ncbi request reprint PPAR-alpha ligands inhibit H2O2-mediated activation of transforming growth factor-beta1 in human mesangial cells
    William A Wilmer
    Division of Nephrology, The Department of Internal Medicine, Dorothy M Davis Heart Lung Research Institute, The Ohio State University College of Medicine, Columbus, OH 43210, USA
    Antioxid Redox Signal 4:877-84. 2002
    ..These studies are the first to identify PPAR-alpha expression by HMC. The results of these studies suggest that TGF-beta1 expression mediated by oxidant stress may be suppressible by PPAR-alpha activation...
  32. pmc Consumption of erythrocyte CR1 (CD35) is associated with protection against systemic lupus erythematosus renal flare
    D J Birmingham
    Division of Nephrology, Department of Internal Medicine, The Davis Heart and Lung Research Institute, The Ohio State University, Columbus, OH 43210, USA
    Clin Exp Immunol 143:274-80. 2006
    ..We postulate that E-CR1 consumption reflects E-CR1 function that includes protecting against SLE nephritis...
  33. ncbi request reprint Cytochrome P450 polymorphisms and the response of lupus nephritis to cyclophosphamide therapy
    J Winoto
    Department of Internal Medicine, Nephrology Division and 2Department of Statistics, The Ohio State University College of Medicine, Columbus, OH 43210, USA
    Clin Nephrol 75:451-7. 2011
    ..This investigation was done to determine the impact of CYP2B6*5 and CYP2C19*2 on the renal response in cyclophosphamide-treated lupus nephritis (LN) patients...
  34. ncbi request reprint Fluctuation in self-perceived stress and increased risk of flare in patients with lupus nephritis carrying the serotonin receptor 1A -1019 G allele
    Daniel J Birmingham
    Ohio State University, Columbus, OH 43210, USA
    Arthritis Rheum 54:3291-9. 2006
    ..The purpose of this study was to assess the relationship between self-perceived stress (SPS), variability in SPS, and the 2 serotonin-related gene polymorphisms as risk factors for SLE flare...
  35. ncbi request reprint Unexpected sensitivity of synthetic Renilla luciferase control vectors to treatment with a cyclopentenone prostaglandin
    Xiaolan Zhang
    Ohio State University College of Medicine and Public Health, Columbus, OH, USA
    Biotechniques 35:1144-6, 1148. 2003
  36. pmc Modulation of cytokine-induced cyclooxygenase 2 expression by PPARG ligands through NFkappaB signal disruption in human WISH and amnion cells
    William E Ackerman
    Department of Obstetrics and Gynecology, Laboratory of Perinatal Research and Division of Maternal Fetal Medicine, The Ohio State University, Columbus, OH 43210, USA
    Biol Reprod 73:527-35. 2005
    ..Our data suggest that pharmacological and endogenous PPARG ligands use both receptor-dependent and -independent mechanisms to influence COX2 expression...
  37. pmc A polymorphism in the type one complement receptor (CR1) involves an additional cysteine within the C3b/C4b binding domain that inhibits ligand binding
    Daniel J Birmingham
    Division of Nephrology, Department of Internal Medicine, The Davis Heart and Lung Research Institute, The Ohio State University, Columbus, OH 43210, United States
    Mol Immunol 44:3510-6. 2007
    ..The physiological role of this polymorphism remains to be determined...
  38. pmc 5/6 nephrectomy as a validated rat model mimicking human warfarin-related nephropathy
    A Ozcan
    Department of Pathology, The Ohio State University, Columbus, Ohio 43210, USA
    Am J Nephrol 35:356-64. 2012
    ..Limitations of the brodifacoum model precluded a careful assessment of dose-response relationships...
  39. ncbi request reprint Renoprotection: one or many therapies?
    L A Hebert
    Division of Nephrology, The Ohio State University Medical Center, Columbus, Ohio, USA
    Kidney Int 59:1211-26. 2001
    ..The goal of this work is to provide the documentation needed for the nephrologist to choose between these strategies...
  40. ncbi request reprint Differentiation-dependent regulation of the cyclooxygenase cascade during adipogenesis suggests a complex role for prostaglandins
    Y Xie
    Department of Obstetrics and Gynecology, Laboratory of Perinatal Research, The Ohio State University, College of Medicine and Public Health, Columbus, OH 43210, USA
    Diabetes Obes Metab 8:83-93. 2006
    ..We examined the expression and cellular localization of enzymes in the cyclooxygenase (COX) cascade that synthesize PGs as well as the PG profile as a function of differentiation status in 3T3-L1 cells...
  41. pmc Induction of chemokine expression by adiponectin in vitro is isoform dependent
    Huijuan Song
    Department of Internal Medicine, The Ohio State University College of Medicine, Columbus, Ohio, USA
    Transl Res 154:18-26. 2009
    ..HMW adiponectin was found in the urine of patients with active lupus nephritis. Therefore, HMW adiponectin may contribute to the renal inflammation of SLE...
  42. pmc Relationship between albuminuria and total proteinuria in systemic lupus erythematosus nephritis: diagnostic and therapeutic implications
    Daniel J Birmingham
    Department of Internal Medicine, Ohio State University Medical Center, Columbus, OH 43210 1250, USA
    Clin J Am Soc Nephrol 3:1028-33. 2008
    ....
  43. ncbi request reprint Mycophenolate therapy of SLE membranous nephropathy
    Dan N Spetie
    Department of Internal Medicine, Dorothy M Davis Heart and Lung Research Institute, The Ohio State University Medical Center, Columbus, Ohio, USA
    Kidney Int 66:2411-5. 2004
    ..Less is known about MMF treatment of membranous SLE GN (WHO Class V, SLE MN)...
  44. ncbi request reprint Thiazide diuretic monotherapy for hypertension: diuretic's dark side just got darker
    B H Rovin
    Department of Internal Medicine, Ohio State University Medical Center, Columbus, Ohio 43210, USA
    Kidney Int 72:1423-6. 2007
    ..Reungjui et al. document a new concern, nephrotoxicity by thiazide monotherapy. This and other recently published evidence of diuretic's 'dark side' is discussed...
  45. ncbi request reprint Alterations in the renal elastin-elastase system in type 1 diabetic nephropathy identified by proteomic analysis
    Visith Thongboonkerd
    Kidney Disease Program, Department of Medicine, University of Louisville, Louisville, Kentucky, USA
    J Am Soc Nephrol 15:650-62. 2004
    ..The identification of these coordinated changes in protein expression in diabetic nephropathy indicates the potential value of proteomic analysis in defining pathophysiology...
  46. pmc Epidermal growth factor and interleukin-1beta utilize divergent signaling pathways to synergistically upregulate cyclooxygenase-2 gene expression in human amnion-derived WISH cells
    William E Ackerman
    Department of Obstetrics and Gynecology Division of Maternal Fetal Medicine and Laboratory of Perinatal Research, The Ohio State University, College of Medicine and Public Health, Columbus, Ohio 43210, USA
    Biol Reprod 71:2079-86. 2004
    ..The synergism observed between IL-1beta and EGF does not rely on augmented NFkappaB function, but rather, occurs through differential use of independent response elements within the COX-2 promoter...
  47. ncbi request reprint The intricate role of complement component C4 in human systemic lupus erythematosus
    Yan Yang
    Center for Molecular and Human Genetics, Columbus Children s Research Institute, Department of Molecular Virology, Immunology and Medical Genetics, Ohio State University, Columbus, Ohio, USA
    Curr Dir Autoimmun 7:98-132. 2004
    ..Likewise, elucidation of epistatic genetic factors interacting with C4AQ0 would provide important insights into the intricate roles of C4 in SLE disease susceptibility and pathogenesis...
  48. ncbi request reprint Three distinct profiles of serum complement C4 proteins in pediatric systemic lupus erythematosus (SLE) patients: tight associations of complement C4 and C3 protein levels in SLE but not in healthy subjects
    Yee Ling Wu
    Columbus Children s Research Institute, The Ohio State University, Columbus, Ohio 43205 USA
    Adv Exp Med Biol 586:227-47. 2006
    ..The third group had normal serum C4 levels (>15 mg/dL) most of the time and occasionally low C4 and C3 levels that were mostly coincident with disease flares prior to effective medical treatment. Most patients in this group..
  49. ncbi request reprint Activation of the Nrf2/antioxidant response pathway increases IL-8 expression
    Xiaolan Zhang
    Department of Internal Medicine, The Dorothy M Davis Heart and Lung Research Institute, The Ohio State University College of Medicine and Public Health, Columbus, OH, USA
    Eur J Immunol 35:3258-67. 2005
    ....
  50. pmc A prospective study of protein excretion using short-interval timed urine collections in patients with lupus nephritis
    Derek M Fine
    Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Kidney Int 76:1284-8. 2009
    ..There was little variability between centers, an important feature for clinical trials...
  51. ncbi request reprint Clinical significance of fever in the systemic lupus erythematosus patient receiving steroid therapy
    Brad H Rovin
    Department of Internal Medicine, The Ohio State University, Columbus, Ohio 43210, USA
    Kidney Int 68:747-59. 2005
    ..Active systemic lupus erythematosus (SLE) can cause fever. Steroids (glucocorticoids) suppress SLE fever; however, the extent to which steroid therapy affects SLE fever not previously been rigorously studied...
  52. ncbi request reprint The design of ALLHAT may have biased the study's outcome in favor of the diuretic cohort
    Lee A Hebert
    Ohio State University Medical Center, 1654 Upham Drive, Columbus, OH 43210, USA
    Nat Clin Pract Nephrol 3:60-1. 2007
  53. doi request reprint Severe hemorrhagic cystitis associated with prolonged oral cyclophosphamide therapy: case report and literature review
    Ruo Qi Hu
    Division of Nephrology, Department of Internal Medicine, The Ohio State University Medical Center, Columbus, OH 43210, USA
    Rheumatol Int 28:1161-4. 2008
    ..This patient is a reminder that severe hemorrhagic cystitis from oral CYP still exists, and that WG can be resistant to even toxic doses of oral CYP. Alternative therapies are discussed...
  54. ncbi request reprint Sensitive and specific real-time polymerase chain reaction assays to accurately determine copy number variations (CNVs) of human complement C4A, C4B, C4-long, C4-short, and RCCX modules: elucidation of C4 CNVs in 50 consanguineous subjects with defined HL
    Yee Ling Wu
    Center for Molecular and Human Genetics, Columbus Children s Research Institute, 700 Children s Drive, Columbus, OH 43205, USA
    J Immunol 179:3012-25. 2007
    ..These C4 qPCR assays are proven to be robust, sensitive, and reliable, as they have contributed to the elucidation of C4 CNVs in >1000 human samples with autoimmune and neurological diseases...
  55. ncbi request reprint Proteinuria in a patient receiving anti-VEGF therapy for metastatic renal cell carcinoma
    Daniel Roncone
    Ohio State University Nephrology Division, Columbus, OH 43210, USA
    Nat Clin Pract Nephrol 3:287-93. 2007
    ..After 9 months of this therapy, the patient developed proteinuria, which gradually increased to over 6 g/day...
  56. doi request reprint Systemic lupus international collaborating clinics renal activity/response exercise: comparison of agreement in rating renal response
    Michelle Petri
    Department of Rheumatology, Johns Hopkins University, Baltimore, Maryland 21205, USA
    Arthritis Rheum 58:1789-95. 2008
    ..To assess the degree to which physicians agree with each other and with ratings obtained with 3 existing responder indices, in rating the response to treatment of lupus nephritis...
  57. pmc HIV-1 infection and AIDS dementia are influenced by a mutant MCP-1 allele linked to increased monocyte infiltration of tissues and MCP-1 levels
    Enrique Gonzalez
    Veterans Administration Research Center for AIDS and HIV 1 Infection and University of Texas Health Science Center, San Antonio, TX 78229, USA
    Proc Natl Acad Sci U S A 99:13795-800. 2002
    ..In a broader context, the MCP-1 -2578G allele may serve as a genetic determinant of outcome of other disease states in which MP-mediated tissue injury is central to disease pathogenesis...
  58. pmc A dinucleotide deletion in CD24 confers protection against autoimmune diseases
    Lizhong Wang
    Division of Immunotherapy, Department of Surgery, Comprehensive Cancer Center, University of Michigan, Ann Arbor, Michigan, United States of America
    PLoS Genet 3:e49. 2007
    ..The dinucleotide deletion significantly reduced the stability of CD24 mRNA. Our results demonstrate that a destabilizing dinucleotide deletion in the 3' UTR of CD24 mRNA conveys significant protection against both MS and SLE...
  59. ncbi request reprint APOE Kyoto mutation in European Americans with lipoprotein glomerulopathy
    Brad H Rovin
    N Engl J Med 357:2522-4. 2007
  60. ncbi request reprint The influence of CCL3L1 gene-containing segmental duplications on HIV-1/AIDS susceptibility
    Enrique Gonzalez
    Veterans Administration Research Center for AIDS and HIV 1 Infection, South Texas Veterans Health Care System, and Department of Medicine, University of Texas Health Science Center, San Antonio, TX 78229, USA
    Science 307:1434-40. 2005
    ....
  61. ncbi request reprint Diagnostic accuracy study of urine dipstick in relation to 24-hour measurement as a screening tool for proteinuria in lupus nephritis
    Mark J Siedner
    Columbia University College of Physicians and Surgeons, New York, NY, USA
    J Rheumatol 35:84-90. 2008
    ..We examined the validity of qualitative urine dipstick versus quantitative 24-hour measurement to accurately detect proteinuria, including low-level proteinuria...
  62. ncbi request reprint Association analysis of the R620W polymorphism of protein tyrosine phosphatase PTPN22 in systemic lupus erythematosus families: increased T allele frequency in systemic lupus erythematosus patients with autoimmune thyroid disease
    Hui Wu
    David Geffen School of Medicine, University of California, Los Angeles, 90095, USA
    Arthritis Rheum 52:2396-402. 2005
    ..We performed family-based association studies of this polymorphism in 4 independent cohorts containing SLE patients and their parents and/or other family members...
  63. pmc Association of a common complement receptor 2 haplotype with increased risk of systemic lupus erythematosus
    Hui Wu
    Division of Rheumatology, University of California Los Angeles, 1000 Veteran Avenue, Los Angeles, CA 90095, USA
    Proc Natl Acad Sci U S A 104:3961-6. 2007
    ..Our findings reveal that CR2 is a likely susceptibility gene for human lupus at 1q32.2, extending previous studies suggesting that CR2 participates in the pathogenesis of systemic lupus erythematosus...
  64. doi request reprint Systemic lupus international collaborating clinics renal activity/response exercise: development of a renal activity score and renal response index
    Michelle Petri
    Department of Rheumatology, Johns Hopkins University, Baltimore, Maryland 21205, USA
    Arthritis Rheum 58:1784-8. 2008
    ..To develop a measure of renal activity in systemic lupus erythematosus and use it to develop a renal response index...
  65. ncbi request reprint Cyclophosphamide or chlorambucil therapy is indicated in idiopathic membranous nephropathy with strong risk factors for progression
    Lee A Hebert
    Am J Kidney Dis 45:788-9; author replyy 789-90. 2005
  66. ncbi request reprint Chemokines: therapeutic targets for autoimmune and inflammatory renal disease
    Vicki Rubin Kelley
    Laboratory of Molecular Autoimmune Disease, Renal Division, Brigham and Women s Hospital, Harvard Medical School, 77 Avenue Louis Pasteur, Boston, MA 02115, USA
    Springer Semin Immunopathol 24:411-21. 2003
  67. ncbi request reprint Activation of Nrf2/ARE pathway protects endothelial cells from oxidant injury and inhibits inflammatory gene expression
    Xi Lin Chen
    Discovery Research, AtheroGenics, Incorporated, Alpharetta, GA 30004, USA
    Am J Physiol Heart Circ Physiol 290:H1862-70. 2006
    ....