Thomas Rosol

Summary

Affiliation: The Ohio State University
Country: USA

Publications

  1. doi request reprint On-target Effects of GLP-1 Receptor Agonists on Thyroid C-cells in Rats and Mice
    Thomas J Rosol
    1The Ohio State University, Department of Veterinary Biosciences, Columbus, Ohio, USA
    Toxicol Pathol 41:303-9. 2013
  2. ncbi request reprint Adrenal gland: structure, function, and mechanisms of toxicity
    T J Rosol
    The Ohio State University, Department of Veterinary Biosciences, Columbus 43210, USA
    Toxicol Pathol 29:41-8. 2001
  3. ncbi request reprint Animal models of bone metastasis
    Thomas J Rosol
    Department of Veterinary Biosciences, The Ohio State University, Columbus, Ohio 43210, USA
    Cancer 97:748-57. 2003
  4. pmc The need for veterinarians in biomedical research
    Thomas J Rosol
    College of Veterinary Medicine, The Ohio State University, Columbus, OH 43210, USA
    J Vet Med Educ 36:70-5. 2009
  5. ncbi request reprint Parathyroid hormone-related protein and ezrin are up-regulated in human lung cancer bone metastases
    Xiyun Deng
    Department of Veterinary Biosciences, The Ohio State University, Columbus, OH 43210, USA
    Clin Exp Metastasis 24:107-19. 2007
  6. ncbi request reprint Effects of hypercalcemia on serum concentrations of magnesium, potassium, and phosphate and urinary excretion of electrolytes in horses
    Ramiro E Toribio
    Department of Veterinary Biosciences, College of Veterinary Medicine, The Ohio State University, Columbus, OH 43210, USA
    Am J Vet Res 68:543-54. 2007
  7. pmc The midregion, nuclear localization sequence, and C terminus of PTHrP regulate skeletal development, hematopoiesis, and survival in mice
    Ramiro E Toribio
    Department of Veterinary Clinical Sciences, The Ohio State University, 601 Vernon Tharp St, Columbus, OH 43210, USA
    FASEB J 24:1947-57. 2010
  8. pmc Expression of parathyroid hormone-related protein during immortalization of human peripheral blood mononuclear cells by HTLV-1: implications for transformation
    Murali V P Nadella
    Department of Veterinary Biosciences, The Ohio State University, Columbus, OH, USA
    Retrovirology 5:46. 2008
  9. ncbi request reprint Dietary (n-3) polyunsaturated fatty acids inhibit HER-2/neu-induced breast cancer in mice independently of the PPARgamma ligand rosiglitazone
    Lisa D Yee
    Department of Surgery, Division of Surgical Oncology, The Ohio State University, Columbus, OH 43210, USA
    J Nutr 135:983-8. 2005
  10. ncbi request reprint Alterations in serum parathyroid hormone and electrolyte concentrations and urinary excretion of electrolytes in horses with induced endotoxemia
    Ramiro E Toribio
    Department of Veterinary Biosciences, College of Veterinary Medicine, The Ohio State University, Columbus, OH 43210, USA
    J Vet Intern Med 19:223-31. 2005

Research Grants

Collaborators

Detail Information

Publications54

  1. doi request reprint On-target Effects of GLP-1 Receptor Agonists on Thyroid C-cells in Rats and Mice
    Thomas J Rosol
    1The Ohio State University, Department of Veterinary Biosciences, Columbus, Ohio, USA
    Toxicol Pathol 41:303-9. 2013
    ..Hyperplasia and neoplasia of C-cells in rodents treated with GLP-1 agonists represent a unique example of an on-target species-specific effect that may not have relevance to humans...
  2. ncbi request reprint Adrenal gland: structure, function, and mechanisms of toxicity
    T J Rosol
    The Ohio State University, Department of Veterinary Biosciences, Columbus 43210, USA
    Toxicol Pathol 29:41-8. 2001
    ..There often are species specificity and age dependence in the development of chemically induced adrenal lesions that should be considered when interpreting toxicity data...
  3. ncbi request reprint Animal models of bone metastasis
    Thomas J Rosol
    Department of Veterinary Biosciences, The Ohio State University, Columbus, Ohio 43210, USA
    Cancer 97:748-57. 2003
    ..Therefore, most experimental models of bone metastasis in rodents require injection or implantation of neoplastic cells into orthotopic locations, bones, or the left ventricle of the heart...
  4. pmc The need for veterinarians in biomedical research
    Thomas J Rosol
    College of Veterinary Medicine, The Ohio State University, Columbus, OH 43210, USA
    J Vet Med Educ 36:70-5. 2009
    ..These actions are necessary for the profession to sustain its viability as an integral part of biomedical research...
  5. ncbi request reprint Parathyroid hormone-related protein and ezrin are up-regulated in human lung cancer bone metastases
    Xiyun Deng
    Department of Veterinary Biosciences, The Ohio State University, Columbus, OH 43210, USA
    Clin Exp Metastasis 24:107-19. 2007
    ....
  6. ncbi request reprint Effects of hypercalcemia on serum concentrations of magnesium, potassium, and phosphate and urinary excretion of electrolytes in horses
    Ramiro E Toribio
    Department of Veterinary Biosciences, College of Veterinary Medicine, The Ohio State University, Columbus, OH 43210, USA
    Am J Vet Res 68:543-54. 2007
    ..To determine effects of experimentally induced hypercalcemia on serum concentrations and urinary excretion of electrolytes, especially ionized magnesium (iMg), in healthy horses...
  7. pmc The midregion, nuclear localization sequence, and C terminus of PTHrP regulate skeletal development, hematopoiesis, and survival in mice
    Ramiro E Toribio
    Department of Veterinary Clinical Sciences, The Ohio State University, 601 Vernon Tharp St, Columbus, OH 43210, USA
    FASEB J 24:1947-57. 2010
    ..The down-regulation of Runx1, Runx2, and Sox9 indicates that PTHrP is a modulator of transcriptional activation during stem cell commitment...
  8. pmc Expression of parathyroid hormone-related protein during immortalization of human peripheral blood mononuclear cells by HTLV-1: implications for transformation
    Murali V P Nadella
    Department of Veterinary Biosciences, The Ohio State University, Columbus, OH, USA
    Retrovirology 5:46. 2008
    ..The expression of PTHrP and the PTH/PTHrP receptor during immortalization or transformation of lymphocytes by HTLV-1 has not been investigated...
  9. ncbi request reprint Dietary (n-3) polyunsaturated fatty acids inhibit HER-2/neu-induced breast cancer in mice independently of the PPARgamma ligand rosiglitazone
    Lisa D Yee
    Department of Surgery, Division of Surgical Oncology, The Ohio State University, Columbus, OH 43210, USA
    J Nutr 135:983-8. 2005
    ..Further studies focusing on the mechanisms by which (n-3) fatty acids suppress HER-2/neu signaling pathways involved in the pathogenesis of breast cancer are warranted...
  10. ncbi request reprint Alterations in serum parathyroid hormone and electrolyte concentrations and urinary excretion of electrolytes in horses with induced endotoxemia
    Ramiro E Toribio
    Department of Veterinary Biosciences, College of Veterinary Medicine, The Ohio State University, Columbus, OH 43210, USA
    J Vet Intern Med 19:223-31. 2005
    ..In conclusion, endotoxemia in horses resulted in electrolyte abnormalities that included hypocalcemia, hypomagnesemia, hypokalemia, hypophosphatemia, and increased serum PTH and insulin concentrations...
  11. ncbi request reprint A novel canine lymphoma cell line: a translational and comparative model for lymphoma research
    William C Kisseberth
    Department of Veterinary Clinical Sciences, College of Veterinary Medicine, The Ohio State University, Columbus, OH 43210, USA
    Leuk Res 31:1709-20. 2007
    ..This cell line and xenograft represent significant in vitro and in vivo models, respectively, for comparative and translational lymphoma research...
  12. ncbi request reprint Hysteresis and calcium set-point for the calcium parathyroid hormone relationship in healthy horses
    Ramiro E Toribio
    Department of Veterinary Biosciences, The Ohio State University, Columbus, OH 43210, USA
    Gen Comp Endocrinol 130:279-88. 2003
    ....
  13. pmc PTHrP 1-141 and 1-86 increase in vitro bone formation
    Blake Eason Hildreth
    Department of Veterinary Clinical Sciences, College of Veterinary Medicine, The Ohio State University, Columbus, Ohio 43210 1089, USA
    J Surg Res 162:e9-17. 2010
    ..Due to evidence that regions of PTHrP other than the N-terminus may have bone-forming effects, this study was designed to compare the effects of full-length PTHrP 1-141 to N-terminal PTHrP 1-86 on in vitro bone formation...
  14. ncbi request reprint RANKL coordinates cell cycle withdrawal and differentiation in osteoclasts through the cyclin-dependent kinase inhibitors p27KIP1 and p21CIP1
    Uma Sankar
    Department of Molecular Genetics, The Ohio State University, Columbus, Ohio 43210, USA
    J Bone Miner Res 19:1339-48. 2004
    ..These cyclin inhibitors may directly regulate osteoclast differentiation in addition to regulating cell cycle withdrawal...
  15. ncbi request reprint Canine prostate induces new bone formation in mouse calvaria: A model of osteoinduction by prostate tissue
    Bruce E LeRoy
    Department of Veterinary Biosciences, The Ohio State University, Columbus, Ohio 43210, USA
    Prostate 50:104-11. 2002
    ..To circumvent these problems, we have developed a model system of new bone formation in the calvaria of nude mice stimulated by normal canine prostate tissue...
  16. pmc Zoledronic acid decreased osteolysis but not bone metastasis in a nude mouse model of canine prostate cancer with mixed bone lesions
    Nanda K Thudi
    Department of Veterinary Biosciences, The Ohio State University, Columbus, Ohio 43210, USA
    Prostate 68:1116-25. 2008
    ..In this study, we hypothesized that tumor-induced osteolysis promoted the incidence of bone metastases and osteoblastic activity...
  17. pmc An ets2-driven transcriptional program in tumor-associated macrophages promotes tumor metastasis
    Tahera Zabuawala
    Department of Molecular and Cellular Biochemistry, Center for Biostatistics, College of Public Health, and Tumor Microenvironment Program, Comprehensive Cancer Center, Ohio State University, Columbus, Ohio 43210, USA
    Cancer Res 70:1323-33. 2010
    ..In summary, we identified Ets2 as a central driver of a transcriptional program in TAMs that acts to promote lung metastasis of breast tumors...
  18. doi request reprint Direct evidence for epithelial-mesenchymal transitions in breast cancer
    ANTHONY J TRIMBOLI
    Department of Molecular Genetics, College of Medicine, The Ohio State University, Columbus, OH 43210, USA
    Cancer Res 68:937-45. 2008
    ..These data provide the first direct evidence for EMT in breast cancer and suggest that its development is favored by myc-initiated events...
  19. pmc A novel bioluminescent mouse model and effective therapy for adult T-cell leukemia/lymphoma
    Sherry T Shu
    Department of Veterinary Biosciences, The Ohio State University, Columbus, Ohio 43214, USA
    Cancer Res 67:11859-66. 2007
    ..PS-341 reduced PTHrP and MIP-1 alpha expression in tumor cells in vivo. Our results indicate that both PS-341 and Zol are effective treatments for ATLL and HHM, which are refractory to conventional therapy...
  20. ncbi request reprint Messenger RNA stability of parathyroid hormone-related protein regulated by transforming growth factor-beta1
    R S Sellers
    Department of Veterinary Biosciences, The Ohio State University, 1925 Coffey Road, Columbus, OH 43210, USA
    Mol Cell Endocrinol 188:37-46. 2002
    ..These studies revealed that TGFbeta1-induced PTHrP mRNA stability might be, in part, the result of cis-acting sequences within the coding region of the PTHrP mRNA...
  21. ncbi request reprint Cloning and sequence analysis of the complementary DNA for feline preproparathyroid hormone
    Ramiro E Toribio
    Department of Veterinary Clinical Sciences, College of Veterinary Medicine, The Ohio State University, Columbus 43210, USA
    Am J Vet Res 63:194-7. 2002
    ..To clone and sequence the cDNA for feline preproparathyroid hormone (preproPTH) and to compare that sequence with other known parathyroid hormone (PTH) sequences...
  22. pmc Pten in stromal fibroblasts suppresses mammary epithelial tumours
    ANTHONY J TRIMBOLI
    Department of Molecular Genetics, College of Biological Sciences, The Ohio State University, Columbus, Ohio 43210, USA
    Nature 461:1084-91. 2009
    ..These findings identify the Pten-Ets2 axis as a critical stroma-specific signalling pathway that suppresses mammary epithelial tumours...
  23. pmc Osteolytic bone resorption in adult T-cell leukemia/lymphoma
    Sherry T Shu
    Department of Veterinary Biosciences, Arthur G James Cancer Hospital and Solove Research Institute, The Ohio State University, Columbus, OH, USA
    Leuk Lymphoma 51:702-14. 2010
    ..In addition, HTLV-1-infected T-cells inhibited expression of early osteoblast genes and induced late genes. These regulators will serve as future therapeutic targets for the treatments of HHM in ATLL...
  24. pmc Zoledronic acid reduces bone loss and tumor growth in an orthotopic xenograft model of osteolytic oral squamous cell carcinoma
    Chelsea K Martin
    Department of Veterinary Biosciences, Ohio State University, Columbus, Ohio 43214, USA
    Cancer Res 70:8607-16. 2010
    ..In summary, our results establish that ZOL can reduce OSCC-induced osteolysis and may be valuable as an adjuvant therapy in OSCC to preserve mandibular and maxillary bone volume and function...
  25. ncbi request reprint Hypercalcemia and high parathyroid hormone-related protein concentration associated with malignant melanoma in a dog
    Barrak M Pressler
    Department of Clinical Sciences, College of Veterinary Medicine, North Carolina State University, Raleigh 27606, USA
    J Am Vet Med Assoc 221:263-5, 240. 2002
    ..Serum parathyroid hormone-related protein concentration was markedly high, and the melanoma had moderate to marked immunostaining for this protein. Paraneoplastic syndromes are rare in dogs with malignant melanoma...
  26. ncbi request reprint Quantitative evaluation of alternative promoter usage and 3' splice variants for parathyroid hormone-related protein by real-time reverse transcription-PCR
    Virgile Richard
    Department of Veterinary Biosciences, College of Veterinary Medicine, The Ohio State University, 1925 Coffey Road, Columbus, OH 43210, USA
    Clin Chem 49:1398-402. 2003
  27. ncbi request reprint Effects of transforming growth factor-beta1 on parathyroid hormone-related protein mRNA expression and protein secretion in canine prostate epithelial, stromal, and carcinoma cells
    Rani S Sellers
    The Department of Veterinary Biosciences, The Ohio State University, Columbus, 43210, USA
    Prostate 58:366-73. 2004
    ..We examined the effect of transforming growth factor-beta1 (TGF beta 1) on PTHrP mRNA expression and PTHrP secretion in normal canine prostate epithelial cells (PEC) and stromal cells (PSC), and in canine prostate carcinoma cells (PCC)...
  28. pmc Animal models of bone metastasis
    Thomas J Rosol
    Department of Veterinary Biosciences, College of Veterinary Medicine, The Ohio State University, Columbus, OH 43210, USA
    Cancer Treat Res 118:47-81. 2004
    ....
  29. doi request reprint Dr. Charles C. Capen--an enduring legacy in veterinary pathology
    Michael Lairmore
    Department of Veterinary Biosciences, The Ohio State University, Columbus, OH, USA
    Vet Pathol 45:285-6. 2008
  30. pmc Developing and fostering a dynamic program for training in veterinary pathology and clinical pathology: veterinary students to post-graduate education
    Michael D Lairmore
    Department of Veterinary Bioscience, The Ohio State University, Columbus, OH 43210 1093, USA
    J Vet Med Educ 34:464-72. 2007
    ....
  31. pmc PTHrP gene expression in cancer: do all paths lead to Ets?
    Virgile Richard
    The Ohio State University Department of Veterinary Biosciences, Columbus, OH 43210, USA
    Crit Rev Eukaryot Gene Expr 15:115-32. 2005
    ..In addition, factors that modulate the entire PTHrP-transcriptional unit, as well as the stability of the mRNA, are being elucidated at the level of cis-acting sequences...
  32. ncbi request reprint New bone formation in nude mouse calvaria induced by canine prostate tissue
    Bruce E LeRoy
    Department of Veterinary Biosciences, The Ohio State University, 1925 Coffey Road, Columbus, OH 43210, USA
    Mol Cell Endocrinol 197:257-63. 2002
    ..In conclusion, this animal model will be useful for investigating the roles of prostate-derived growth factors on new bone formation in vivo...
  33. pmc Rb function in extraembryonic lineages suppresses apoptosis in the CNS of Rb-deficient mice
    Alain de Bruin
    Human Cancer Genetics Program, Department of Molecular Virology, Immunology, and Medical Genetics, Ohio State University, Columbus 43210, USA
    Proc Natl Acad Sci U S A 100:6546-51. 2003
    ....
  34. pmc The role of Dickkopf-1 in bone development, homeostasis, and disease
    Joseph J Pinzone
    Department of Internal Medicine, The Ohio State University, Columbus, USA
    Blood 113:517-25. 2009
    ..Here, we review the rapidly growing body of literature defining a pivotal role for DKK1 in bone health and disease...
  35. ncbi request reprint Pharmacokinetic parameters as a potential predictor of response to pharmacotherapy in benign prostatic hyperplasia: a preclinical trial using dynamic contrast-enhanced MRI
    Guang Jia
    Department of Radiology, The Ohio State University, Columbus, OH 43210, USA
    Magn Reson Imaging 24:721-5. 2006
    ..Larger prostate volume reductions coincided with smaller initial parenchymal MER. These findings show considerable promise of using parenchymal MER as a predictor of response to BPH pharmacotherapy with finasteride...
  36. doi request reprint Bone-invasive oral squamous cell carcinoma in cats: pathology and expression of parathyroid hormone-related protein
    C K Martin
    Department of Veterinary Biosciences, The Ohio State University, 1925 Coffey Road, Columbus, Ohio 43214, USA
    Vet Pathol 48:302-12. 2011
    ..Increased tumor expression of PTHrP and increased localization of PTHrP to the nucleus were associated with osteolysis and may play an important role in bone resorption and tumor invasion in cats with OSCC...
  37. doi request reprint Mouse development with a single E2F activator
    Shih Yin Tsai
    Department of Molecular Genetics, College of Biological Sciences, The Ohio State University, Columbus, Ohio 43210, USA
    Nature 454:1137-41. 2008
    ..These findings provide a molecular basis for the observed specificity among E2F activators during development...
  38. ncbi request reprint Dynamic contrast enhanced magnetic resonance imaging as a biological marker to noninvasively assess the effect of finasteride on prostatic suburethral microcirculation
    Guang Jia
    Department of Radiology, Ohio State University, Columbus, Ohio, USA
    J Urol 176:2299-304. 2006
    ..We assessed dynamic contrast enhanced magnetic resonance imaging as a biological marker of in vivo changes in microcirculation in the prostatic suburethral region...
  39. ncbi request reprint Molecular cloning and expression of equine calcitonin, calcitonin gene-related peptide-I, and calcitonin gene-related peptide-II
    Ramiro E Toribio
    Department of Veterinary Biosciences, College of Veterinary Medicine, The Ohio State University, 1925 Coffey Road, Columbus 43210, USA
    Mol Cell Endocrinol 199:119-28. 2003
    ..CGRPs are widely expressed in tissues of the central and peripheral nervous system. Information from this study will be valuable to study the role of CT, CGRP-I, and CGRP-II in equine health and disease...
  40. ncbi request reprint Assessing prostate volume by magnetic resonance imaging: a comparison of different measurement approaches for organ volume analysis
    Guang Jia
    Department of Radiology, The Ohio State University, Columbus, OH 43210, USA
    Invest Radiol 40:243-8. 2005
    ..We sought to evaluate the capabilities of different magnetic resonance imaging (MRI)-based methodologies for measuring prostate volume...
  41. ncbi request reprint Extra-embryonic function of Rb is essential for embryonic development and viability
    Lizhao Wu
    Human Cancer Genetics Program, Department of Molecular Virology, Immunology and Medical Genetics, The Ohio State University, Columbus, Ohio 43210, USA
    Nature 421:942-7. 2003
    ....
  42. ncbi request reprint Specificity of E2F1, E2F2, and E2F3 in mediating phenotypes induced by loss of Rb
    Harold I Saavedra
    Human Cancer Genetics Program, Department of Molecular Virology, Immunology and Medical Genetics and Department of Molecular Genetics, The Ohio State University, Columbus 43210, USA
    Cell Growth Differ 13:215-25. 2002
    ..These results provide clear evidence for functional specificity among E2Fs in the control of Rb-dependent proliferation and apoptosis in a tissue-specific manner...
  43. ncbi request reprint Biodegradable nanoparticles for targeted ultrasound imaging of breast cancer cells in vitro
    Jun Liu
    Department of Biomedical Engineering, Ohio State University, 270 Bevis Hall, 1080 Carmack Road, Columbus, OH 43210, USA
    Phys Med Biol 52:4739-47. 2007
    ..In conclusion, the feasibility of using targeted nanoparticles to enhance ultrasonic images was demonstrated in vitro. This may be a promising approach to target cancer biomarkers for site-specific ultrasound imaging...
  44. ncbi request reprint A blocking antibody to nerve growth factor attenuates skeletal pain induced by prostate tumor cells growing in bone
    Kyle G Halvorson
    Department of Diagnostic and Biological Sciences, University of Minnesota, MN 55455, USA
    Cancer Res 65:9426-35. 2005
    ..The present results suggest that anti-NGF therapy may be effective in reducing pain and enhancing the quality of life in patients with prostate tumor-induced bone cancer pain...
  45. doi request reprint Tumor expressed PTHrP facilitates prostate cancer-induced osteoblastic lesions
    Jinhui Liao
    Department of Periodontics and Oral Medicine, School of Dentistry, University of Michigan, Ann Arbor, MI, USA
    Int J Cancer 123:2267-78. 2008
    ..Prostate cancer-derived PTHrP is actively involved in osteoblastic skeletal progression...
  46. ncbi request reprint Canine prostate stimulates osteoblast function using the endothelin receptors
    Bruce E LeRoy
    Department of Pathology, University of Georgia, Athens, Georgia, USA
    Prostate 59:148-56. 2004
    ..We hypothesized that stimulation of osteoblasts by prostate tissue at metastatic sites was due to the paracrine actions of growth factors produced by prostate epithelial cells...
  47. ncbi request reprint Detection of parathyroid hormone-related protein in cats with humoral hypercalcemia of malignancy
    Anne Provencher Bolliger
    Endocrine Diagnostic Section, Animal Health Diagnostic Laboratory, Michigan State University, East Lansing, MI 48824, USA
    Vet Clin Pathol 31:3-8. 2002
    ..A commercially available assay for human PTHrP has diagnostic utility in the dog, but has not been assessed in cats...
  48. ncbi request reprint New bone formation and osteolysis by a metastatic, highly invasive canine prostate carcinoma xenograft
    Bruce E LeRoy
    Department of Pathology, University of Georgia, Athens, GA, USA
    Prostate 66:1213-22. 2006
    ..Osteoblastic metastases are commonly induced by prostate cancer. A canine prostate carcinoma xenograft (Ace-1) was developed and used to evaluate neoplastic prostate cell growth, metastasis, and effects on bone formation in nude mice...
  49. ncbi request reprint Engraftment and tumorigenesis of HTLV-1 transformed T cell lines in SCID/bg and NOD/SCID mice
    Yingxian Liu
    Department of Microbiology and Immunology, SUNY Upstate Medical University, 750 East Adams St, Syracuse, NY 13210, USA
    Leuk Res 26:561-7. 2002
    ..The higher level of engraftment of HTLV-1 transformed cell lines in NOD/SCID mice suggests that this is an effective animal model to investigate molecular determinants of HTLV-1 lymphomagenesis...
  50. ncbi request reprint In vivo visualization of metastatic prostate cancer and quantitation of disease progression in immunocompromised mice
    Linda M Kalikin
    Department of Urology, Division of Hematology and Oncology, The University of Michigan Comprehensive Cancer Center, Ann Arbor, Michigan 48109 0946, USA
    Cancer Biol Ther 2:656-60. 2003
    ..This model provides a controllable biological system for further investigation into the pathogenesis of metastatic prostate cancer and evaluation of new therapies...
  51. ncbi request reprint Similarities and differences in tumor growth, skeletal remodeling and pain in an osteolytic and osteoblastic model of bone cancer
    Kyle G Halvorson
    Neurosystems Center and Department of Diagnostic and Biological Sciences, University of Minnesota, Minneapolis, 55455, USA
    Clin J Pain 22:587-600. 2006
    ..As analgesics can also influence disease progression, findings from these studies may lead to therapies that have the potential to improve the quality of life and survival of patients with skeletal malignancies...
  52. ncbi request reprint Effects of chlorpromazine, pentoxifylline and dexamethasone on mRNA expression of lipopolysaccharide-induced inflammatory cytokines in bovine peripheral blood mononuclear cells
    Yoshio Kiku
    Department of Veterinary Pathology, large animal Clincal Center, School of Veterinary Medicine, Rakuno Gakuen University, Ebetsu, Hokkaido, Japan
    J Vet Med Sci 64:723-6. 2002
    ..These results indicated that pretreatment with CPZ and DEX might be effective to reduce the production of LPS-induced inflammatory cytokines in bovine PBMCs in vitro...
  53. ncbi request reprint In vitro cyclooxygenase-2 protein expression and enzymatic activity in neoplastic cells
    David A Heller
    Departments of Veterinary Clinical Medicine, Comparative Oncology Research Laboratory, University of Illinois at Urbana Champaign, Urbana, IL, USA
    J Vet Intern Med 21:1048-55. 2007
    ..Based upon immunohistochemical (IHC) evidence that several tumor types in animals overexpress COX-2 protein, COX-2 inhibitors are used as anticancer agents in dogs and cats...
  54. ncbi request reprint Regulation of parathyroid hormone-related protein gene expression by epidermal growth factor-family ligands in primary human keratinocytes
    Yong Mee Cho
    Medical Sciences, Indiana University School of Medicine, Bloomington, Indiana 47405, USA
    J Endocrinol 181:179-90. 2004
    ..These findings suggest that acquisition of EGF-like ligand expression has the potential to substantially activate PTHrP gene expression in the epidermis...

Research Grants6

  1. Measurement of Cells In Vivo: IVIS Light Imaging System
    Thomas Rosol; Fiscal Year: 2003
    ..Space and utilities for the instrument plus salary and benefits for the supervisor will be provided by the Department of Veterinary Biosciences and the College of Veterinary Medicine. ..