Research Topics
| Thomas RosolSummaryAffiliation: The Ohio State University Country: USA Publications
Research Grants
| Collaborators
|
Detail Information
Publications
On-target effects of GLP-1 receptor agonists on thyroid C-cells in rats and miceThomas J Rosol
The Ohio State University, Department of Veterinary Biosciences, Columbus, Ohio 43210, USA
Toxicol Pathol 41:303-9. 2013..Hyperplasia and neoplasia of C-cells in rodents treated with GLP-1 agonists represent a unique example of an on-target species-specific effect that may not have relevance to humans...
Adrenal gland: structure, function, and mechanisms of toxicityT J Rosol
The Ohio State University, Department of Veterinary Biosciences, Columbus 43210, USA
Toxicol Pathol 29:41-8. 2001..There often are species specificity and age dependence in the development of chemically induced adrenal lesions that should be considered when interpreting toxicity data...- Animal models of bone metastasisThomas J Rosol
Department of Veterinary Biosciences, The Ohio State University, Columbus, Ohio 43210, USA
Cancer 97:748-57. 2003..Therefore, most experimental models of bone metastasis in rodents require injection or implantation of neoplastic cells into orthotopic locations, bones, or the left ventricle of the heart... 
The need for veterinarians in biomedical researchThomas J Rosol
College of Veterinary Medicine, The Ohio State University, Columbus, OH 43210, USA
J Vet Med Educ 36:70-5. 2009..These actions are necessary for the profession to sustain its viability as an integral part of biomedical research...- Parathyroid hormone-related protein and ezrin are up-regulated in human lung cancer bone metastasesXiyun Deng
Department of Veterinary Biosciences, The Ohio State University, Columbus, OH 43210, USA
Clin Exp Metastasis 24:107-19. 2007.... - Effects of hypercalcemia on serum concentrations of magnesium, potassium, and phosphate and urinary excretion of electrolytes in horsesRamiro E Toribio
Department of Veterinary Biosciences, College of Veterinary Medicine, The Ohio State University, Columbus, OH 43210, USA
Am J Vet Res 68:543-54. 2007..To determine effects of experimentally induced hypercalcemia on serum concentrations and urinary excretion of electrolytes, especially ionized magnesium (iMg), in healthy horses... - The midregion, nuclear localization sequence, and C terminus of PTHrP regulate skeletal development, hematopoiesis, and survival in miceRamiro E Toribio
Department of Veterinary Clinical Sciences, The Ohio State University, 601 Vernon Tharp St, Columbus, OH 43210, USA
FASEB J 24:1947-57. 2010..The down-regulation of Runx1, Runx2, and Sox9 indicates that PTHrP is a modulator of transcriptional activation during stem cell commitment... - Expression of parathyroid hormone-related protein during immortalization of human peripheral blood mononuclear cells by HTLV-1: implications for transformationMurali V P Nadella
Department of Veterinary Biosciences, The Ohio State University, Columbus, OH, USA
Retrovirology 5:46. 2008..The expression of PTHrP and the PTH/PTHrP receptor during immortalization or transformation of lymphocytes by HTLV-1 has not been investigated... - Dietary (n-3) polyunsaturated fatty acids inhibit HER-2/neu-induced breast cancer in mice independently of the PPARgamma ligand rosiglitazoneLisa D Yee
Department of Surgery, Division of Surgical Oncology, The Ohio State University, Columbus, OH 43210, USA
J Nutr 135:983-8. 2005..Further studies focusing on the mechanisms by which (n-3) fatty acids suppress HER-2/neu signaling pathways involved in the pathogenesis of breast cancer are warranted... - Alterations in serum parathyroid hormone and electrolyte concentrations and urinary excretion of electrolytes in horses with induced endotoxemiaRamiro E Toribio
Department of Veterinary Biosciences, College of Veterinary Medicine, The Ohio State University, Columbus, OH 43210, USA
J Vet Intern Med 19:223-31. 2005..In conclusion, endotoxemia in horses resulted in electrolyte abnormalities that included hypocalcemia, hypomagnesemia, hypokalemia, hypophosphatemia, and increased serum PTH and insulin concentrations... - A novel canine lymphoma cell line: a translational and comparative model for lymphoma researchWilliam C Kisseberth
Department of Veterinary Clinical Sciences, College of Veterinary Medicine, The Ohio State University, Columbus, OH 43210, USA
Leuk Res 31:1709-20. 2007..This cell line and xenograft represent significant in vitro and in vivo models, respectively, for comparative and translational lymphoma research... - Hysteresis and calcium set-point for the calcium parathyroid hormone relationship in healthy horsesRamiro E Toribio
Department of Veterinary Biosciences, The Ohio State University, Columbus, OH 43210, USA
Gen Comp Endocrinol 130:279-88. 2003.... - PTHrP 1-141 and 1-86 increase in vitro bone formationBlake Eason Hildreth
Department of Veterinary Clinical Sciences, College of Veterinary Medicine, The Ohio State University, Columbus, Ohio 43210 1089, USA
J Surg Res 162:e9-17. 2010..Due to evidence that regions of PTHrP other than the N-terminus may have bone-forming effects, this study was designed to compare the effects of full-length PTHrP 1-141 to N-terminal PTHrP 1-86 on in vitro bone formation... - RANKL coordinates cell cycle withdrawal and differentiation in osteoclasts through the cyclin-dependent kinase inhibitors p27KIP1 and p21CIP1Uma Sankar
Department of Molecular Genetics, The Ohio State University, Columbus, Ohio 43210, USA
J Bone Miner Res 19:1339-48. 2004..These cyclin inhibitors may directly regulate osteoclast differentiation in addition to regulating cell cycle withdrawal... - Canine prostate induces new bone formation in mouse calvaria: A model of osteoinduction by prostate tissueBruce E LeRoy
Department of Veterinary Biosciences, The Ohio State University, Columbus, Ohio 43210, USA
Prostate 50:104-11. 2002..CONCLUSIONS: This animal model will be useful for investigating the roles of prostate-derived growth factors on new bone formation in vivo... - Zoledronic acid decreased osteolysis but not bone metastasis in a nude mouse model of canine prostate cancer with mixed bone lesionsNanda K Thudi
Department of Veterinary Biosciences, The Ohio State University, Columbus, Ohio 43210, USA
Prostate 68:1116-25. 2008..In this study, we hypothesized that tumor-induced osteolysis promoted the incidence of bone metastases and osteoblastic activity... - An ets2-driven transcriptional program in tumor-associated macrophages promotes tumor metastasisTahera Zabuawala
Department of Molecular and Cellular Biochemistry, Center for Biostatistics, College of Public Health, and Tumor Microenvironment Program, Comprehensive Cancer Center, Ohio State University, Columbus, Ohio 43210, USA
Cancer Res 70:1323-33. 2010..In summary, we identified Ets2 as a central driver of a transcriptional program in TAMs that acts to promote lung metastasis of breast tumors... - Direct evidence for epithelial-mesenchymal transitions in breast cancerANTHONY J TRIMBOLI
Department of Molecular Genetics, College of Medicine, The Ohio State University, Columbus, OH 43210, USA
Cancer Res 68:937-45. 2008..These data provide the first direct evidence for EMT in breast cancer and suggest that its development is favored by myc-initiated events... - A novel bioluminescent mouse model and effective therapy for adult T-cell leukemia/lymphomaSherry T Shu
Department of Veterinary Biosciences, The Ohio State University, Columbus, Ohio 43214, USA
Cancer Res 67:11859-66. 2007..PS-341 reduced PTHrP and MIP-1 alpha expression in tumor cells in vivo. Our results indicate that both PS-341 and Zol are effective treatments for ATLL and HHM, which are refractory to conventional therapy... - Messenger RNA stability of parathyroid hormone-related protein regulated by transforming growth factor-beta1R S Sellers
Department of Veterinary Biosciences, The Ohio State University, 1925 Coffey Road, Columbus, OH 43210, USA
Mol Cell Endocrinol 188:37-46. 2002..These studies revealed that TGFbeta1-induced PTHrP mRNA stability might be, in part, the result of cis-acting sequences within the coding region of the PTHrP mRNA... - Cloning and sequence analysis of the complementary DNA for feline preproparathyroid hormoneRamiro E Toribio
Department of Veterinary Clinical Sciences, College of Veterinary Medicine, The Ohio State University, Columbus 43210, USA
Am J Vet Res 63:194-7. 2002..Knowledge of the cDNA sequence for feline PTH may be useful to investigate disturbances of calcium metabolism and alterations in PTH expression in cats... - Pten in stromal fibroblasts suppresses mammary epithelial tumoursANTHONY J TRIMBOLI
Department of Molecular Genetics, College of Biological Sciences, The Ohio State University, Columbus, Ohio 43210, USA
Nature 461:1084-91. 2009..These findings identify the Pten-Ets2 axis as a critical stroma-specific signalling pathway that suppresses mammary epithelial tumours... - Osteolytic bone resorption in adult T-cell leukemia/lymphomaSherry T Shu
Department of Veterinary Biosciences, Arthur G James Cancer Hospital and Solove Research Institute, The Ohio State University, Columbus, OH, USA
Leuk Lymphoma 51:702-14. 2010..In addition, HTLV-1-infected T-cells inhibited expression of early osteoblast genes and induced late genes. These regulators will serve as future therapeutic targets for the treatments of HHM in ATLL... - Zoledronic acid reduces bone loss and tumor growth in an orthotopic xenograft model of osteolytic oral squamous cell carcinomaChelsea K Martin
Department of Veterinary Biosciences, Ohio State University, Columbus, Ohio 43214, USA
Cancer Res 70:8607-16. 2010..In summary, our results establish that ZOL can reduce OSCC-induced osteolysis and may be valuable as an adjuvant therapy in OSCC to preserve mandibular and maxillary bone volume and function... - Hypercalcemia and high parathyroid hormone-related protein concentration associated with malignant melanoma in a dogBarrak M Pressler
Department of Clinical Sciences, College of Veterinary Medicine, North Carolina State University, Raleigh 27606, USA
J Am Vet Med Assoc 221:263-5, 240. 2002..Serum parathyroid hormone-related protein concentration was markedly high, and the melanoma had moderate to marked immunostaining for this protein. Paraneoplastic syndromes are rare in dogs with malignant melanoma... - Quantitative evaluation of alternative promoter usage and 3' splice variants for parathyroid hormone-related protein by real-time reverse transcription-PCRVirgile Richard
Department of Veterinary Biosciences, College of Veterinary Medicine, The Ohio State University, 1925 Coffey Road, Columbus, OH 43210, USA
Clin Chem 49:1398-402. 2003 - Effects of transforming growth factor-beta1 on parathyroid hormone-related protein mRNA expression and protein secretion in canine prostate epithelial, stromal, and carcinoma cellsRani S Sellers
The Department of Veterinary Biosciences, The Ohio State University, Columbus, 43210, USA
Prostate 58:366-73. 2004..CONCLUSIONS: TGF beta 1 increased PTHrP mRNA expression in canine PEC and PCC, and decreased expression in PSC. This regulatory pathway may be important in the pathogenesis of osteoblastic metastases... - Animal models of bone metastasisThomas J Rosol
Department of Veterinary Biosciences, College of Veterinary Medicine, The Ohio State University, Columbus, OH 43210, USA
Cancer Treat Res 118:47-81. 2004.... - Dr. Charles C. Capen--an enduring legacy in veterinary pathologyMichael Lairmore
Department of Veterinary Biosciences, The Ohio State University, Columbus, OH, USA
Vet Pathol 45:285-6. 2008 - Developing and fostering a dynamic program for training in veterinary pathology and clinical pathology: veterinary students to post-graduate educationMichael D Lairmore
Department of Veterinary Bioscience, The Ohio State University, Columbus, OH 43210 1093, USA
J Vet Med Educ 34:464-72. 2007.... - PTHrP gene expression in cancer: do all paths lead to Ets?Virgile Richard
The Ohio State University Department of Veterinary Biosciences, Columbus, OH 43210, USA
Crit Rev Eukaryot Gene Expr 15:115-32. 2005..In addition, factors that modulate the entire PTHrP-transcriptional unit, as well as the stability of the mRNA, are being elucidated at the level of cis-acting sequences... - New bone formation in nude mouse calvaria induced by canine prostate tissueBruce E LeRoy
Department of Veterinary Biosciences, The Ohio State University, 1925 Coffey Road, Columbus, OH 43210, USA
Mol Cell Endocrinol 197:257-63. 2002..In conclusion, this animal model will be useful for investigating the roles of prostate-derived growth factors on new bone formation in vivo... - Rb function in extraembryonic lineages suppresses apoptosis in the CNS of Rb-deficient miceAlain de Bruin
Human Cancer Genetics Program, Department of Molecular Virology, Immunology, and Medical Genetics, Ohio State University, Columbus 43210, USA
Proc Natl Acad Sci U S A 100:6546-51. 2003.... - The role of Dickkopf-1 in bone development, homeostasis, and diseaseJoseph J Pinzone
Department of Internal Medicine, The Ohio State University, Columbus, USA
Blood 113:517-25. 2009..Here, we review the rapidly growing body of literature defining a pivotal role for DKK1 in bone health and disease... - Pharmacokinetic parameters as a potential predictor of response to pharmacotherapy in benign prostatic hyperplasia: a preclinical trial using dynamic contrast-enhanced MRIGuang Jia
Department of Radiology, The Ohio State University, Columbus, OH 43210, USA
Magn Reson Imaging 24:721-5. 2006..Larger prostate volume reductions coincided with smaller initial parenchymal MER. These findings show considerable promise of using parenchymal MER as a predictor of response to BPH pharmacotherapy with finasteride... - Bone-invasive oral squamous cell carcinoma in cats: pathology and expression of parathyroid hormone-related proteinC K Martin
Department of Veterinary Biosciences, The Ohio State University, 1925 Coffey Road, Columbus, Ohio 43214, USA
Vet Pathol 48:302-12. 2011..Increased tumor expression of PTHrP and increased localization of PTHrP to the nucleus were associated with osteolysis and may play an important role in bone resorption and tumor invasion in cats with OSCC... - Mouse development with a single E2F activatorShih Yin Tsai
Department of Molecular Genetics, College of Biological Sciences, The Ohio State University, Columbus, Ohio 43210, USA
Nature 454:1137-41. 2008..These findings provide a molecular basis for the observed specificity among E2F activators during development... - Dynamic contrast enhanced magnetic resonance imaging as a biological marker to noninvasively assess the effect of finasteride on prostatic suburethral microcirculationGuang Jia
Department of Radiology, Ohio State University, Columbus, Ohio, USA
J Urol 176:2299-304. 2006..A relevant clinical application could be the pretreatment assessment of finasteride effectiveness to decrease perioperative bleeding at transurethral prostate resection and in treatment for hematuria... - Molecular cloning and expression of equine calcitonin, calcitonin gene-related peptide-I, and calcitonin gene-related peptide-IIRamiro E Toribio
Department of Veterinary Biosciences, College of Veterinary Medicine, The Ohio State University, 1925 Coffey Road, Columbus 43210, USA
Mol Cell Endocrinol 199:119-28. 2003..CGRPs are widely expressed in tissues of the central and peripheral nervous system. Information from this study will be valuable to study the role of CT, CGRP-I, and CGRP-II in equine health and disease... - Assessing prostate volume by magnetic resonance imaging: a comparison of different measurement approaches for organ volume analysisGuang Jia
Department of Radiology, The Ohio State University, Columbus, OH 43210, USA
Invest Radiol 40:243-8. 2005..CONCLUSIONS: MRI-based segmentation is highly accurate in assessing prostate volume. Diameter-based measurements are closely correlated to the segmented prostate volume and are feasible to monitor therapy... - Extra-embryonic function of Rb is essential for embryonic development and viabilityLizhao Wu
Human Cancer Genetics Program, Department of Molecular Virology, Immunology and Medical Genetics, The Ohio State University, Columbus, Ohio 43210, USA
Nature 421:942-7. 2003.... - Specificity of E2F1, E2F2, and E2F3 in mediating phenotypes induced by loss of RbHarold I Saavedra
Human Cancer Genetics Program, Department of Molecular Virology, Immunology and Medical Genetics and Department of Molecular Genetics, The Ohio State University, Columbus 43210, USA
Cell Growth Differ 13:215-25. 2002..These results provide clear evidence for functional specificity among E2Fs in the control of Rb-dependent proliferation and apoptosis in a tissue-specific manner... - Biodegradable nanoparticles for targeted ultrasound imaging of breast cancer cells in vitroJun Liu
Department of Biomedical Engineering, Ohio State University, 270 Bevis Hall, 1080 Carmack Road, Columbus, OH 43210, USA
Phys Med Biol 52:4739-47. 2007..In conclusion, the feasibility of using targeted nanoparticles to enhance ultrasonic images was demonstrated in vitro. This may be a promising approach to target cancer biomarkers for site-specific ultrasound imaging... - A blocking antibody to nerve growth factor attenuates skeletal pain induced by prostate tumor cells growing in boneKyle G Halvorson
Department of Diagnostic and Biological Sciences, University of Minnesota, MN 55455, USA
Cancer Res 65:9426-35. 2005..The present results suggest that anti-NGF therapy may be effective in reducing pain and enhancing the quality of life in patients with prostate tumor-induced bone cancer pain... - Tumor expressed PTHrP facilitates prostate cancer-induced osteoblastic lesionsJinhui Liao
Department of Periodontics and Oral Medicine, School of Dentistry, University of Michigan, Ann Arbor, MI, USA
Int J Cancer 123:2267-78. 2008..Prostate cancer-derived PTHrP is actively involved in osteoblastic skeletal progression... - Canine prostate stimulates osteoblast function using the endothelin receptorsBruce E LeRoy
Department of Pathology, University of Georgia, Athens, Georgia, USA
Prostate 59:148-56. 2004..This is a reliable, reproducible assay for determining the roles of molecules important in the activation of osteoblasts by the prostate... - Detection of parathyroid hormone-related protein in cats with humoral hypercalcemia of malignancyAnne Provencher Bolliger
Endocrine Diagnostic Section, Animal Health Diagnostic Laboratory, Michigan State University, East Lansing, MI 48824, USA
Vet Clin Pathol 31:3-8. 2002..A commercially available assay for human PTHrP has diagnostic utility in the dog, but has not been assessed in cats... - New bone formation and osteolysis by a metastatic, highly invasive canine prostate carcinoma xenograftBruce E LeRoy
Department of Pathology, University of Georgia, Athens, GA, USA
Prostate 66:1213-22. 2006..CONCLUSIONS: The Ace-1 xenograft is a useful model for investigating the pathogenesis of prostate cancer invasion and mixed osteoblastic/osteolytic bone metastases... - Engraftment and tumorigenesis of HTLV-1 transformed T cell lines in SCID/bg and NOD/SCID miceYingxian Liu
Department of Microbiology and Immunology, SUNY Upstate Medical University, 750 East Adams St, Syracuse, NY 13210, USA
Leuk Res 26:561-7. 2002..The higher level of engraftment of HTLV-1 transformed cell lines in NOD/SCID mice suggests that this is an effective animal model to investigate molecular determinants of HTLV-1 lymphomagenesis... - In vivo visualization of metastatic prostate cancer and quantitation of disease progression in immunocompromised miceLinda M Kalikin
Department of Urology, Division of Hematology and Oncology, The University of Michigan Comprehensive Cancer Center, Ann Arbor, Michigan 48109-0946, USA
Cancer Biol Ther 2:656-60. 2003..This model provides a controllable biological system for further investigation into the pathogenesis of metastatic prostate cancer and evaluation of new therapies... - Similarities and differences in tumor growth, skeletal remodeling and pain in an osteolytic and osteoblastic model of bone cancerKyle G Halvorson
Neurosystems Center and Department of Diagnostic and Biological Sciences, University of Minnesota, Minneapolis, 55455, USA
Clin J Pain 22:587-600. 2006..As analgesics can also influence disease progression, findings from these studies may lead to therapies that have the potential to improve the quality of life and survival of patients with skeletal malignancies... - Effects of chlorpromazine, pentoxifylline and dexamethasone on mRNA expression of lipopolysaccharide-induced inflammatory cytokines in bovine peripheral blood mononuclear cellsYoshio Kiku
Department of Veterinary Pathology, large animal Clincal Center, School of Veterinary Medicine, Rakuno Gakuen University, Ebetsu, Hokkaido, Japan
J Vet Med Sci 64:723-6. 2002..These results indicated that pretreatment with CPZ and DEX might be effective to reduce the production of LPS-induced inflammatory cytokines in bovine PBMCs in vitro... - In vitro cyclooxygenase-2 protein expression and enzymatic activity in neoplastic cellsDavid A Heller
Departments of Veterinary Clinical Medicine, Comparative Oncology Research Laboratory, University of Illinois at Urbana Champaign, Urbana, IL, USA
J Vet Intern Med 21:1048-55. 2007..Based upon immunohistochemical (IHC) evidence that several tumor types in animals overexpress COX-2 protein, COX-2 inhibitors are used as anticancer agents in dogs and cats... - Regulation of parathyroid hormone-related protein gene expression by epidermal growth factor-family ligands in primary human keratinocytesYong-Mee Cho
Medical Sciences, Indiana University School of Medicine, Bloomington, Indiana 47405, USA
J Endocrinol 181:179-90. 2004..These findings suggest that acquisition of EGF-like ligand expression has the potential to substantially activate PTHrP gene expression in the epidermis...
Research Grants
- Measurement of Cells In Vivo: IVIS Light Imaging SystemThomas Rosol; Fiscal Year: 2003..Space and utilities for the instrument plus salary and benefits for the supervisor will be provided by the Department of Veterinary Biosciences and the College of Veterinary Medicine. ..