David I Rosenthal

Summary

Affiliation: The University of Texas
Country: USA

Publications

  1. ncbi Sinonasal neuroendocrine carcinoma: impact of differentiation status on response and outcome
    Anna Likhacheva
    Department of Radian Oncology, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX 77030, USA
    Head Neck Oncol 3:32. 2011
  2. ncbi Head and neck squamous cell carcinoma: optimizing the therapeutic index
    David I Rosenthal
    Department of Radiation Oncology, 097, The University of Texas, MD Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030 4009, USA
    Expert Rev Anticancer Ther 5:501-14. 2005
  3. ncbi Prevention and treatment of dysphagia and aspiration after chemoradiation for head and neck cancer
    David I Rosenthal
    Department of Head and Neck Surgery, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    J Clin Oncol 24:2636-43. 2006
  4. ncbi Early postoperative paclitaxel followed by concurrent paclitaxel and cisplatin with radiation therapy for patients with resected high-risk head and neck squamous cell carcinoma: report of the phase II trial RTOG 0024
    David I Rosenthal
    Department of Radiation Oncology, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    J Clin Oncol 27:4727-32. 2009
  5. ncbi Phase I study of Paclitaxel given by seven-week continuous infusion concurrent with radiation therapy for locally advanced non-small cell lung cancer
    David I Rosenthal
    Department of Radiation Oncology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    J Thorac Oncol 1:38-45. 2006
  6. ncbi Phase I study of preoperative radiation therapy with concurrent infusional 5-fluorouracil and oxaliplatin followed by surgery and postoperative 5-fluorouracil plus leucovorin for T3/T4 rectal adenocarcinoma: ECOG E1297
    David I Rosenthal
    Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA
    Int J Radiat Oncol Biol Phys 72:108-13. 2008
  7. ncbi Simple carotid-sparing intensity-modulated radiotherapy technique and preliminary experience for T1-2 glottic cancer
    David I Rosenthal
    Department of Radiation Oncology, University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Int J Radiat Oncol Biol Phys 77:455-61. 2010
  8. ncbi Strategies for managing radiation-induced mucositis in head and neck cancer
    David I Rosenthal
    Department of Radiation Oncology, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Semin Radiat Oncol 19:29-34. 2009
  9. ncbi Sinonasal malignancies with neuroendocrine differentiation: patterns of failure according to histologic phenotype
    David I Rosenthal
    Department of Radiation Oncology, The University of Texas M D Anderson Cancer Center, Houston, Texas, USA
    Cancer 101:2567-73. 2004
  10. ncbi A phase II study to assess the efficacy of amifostine for submandibular/sublingual salivary sparing during the treatment of head and neck cancer with intensity modulated radiation therapy for parotid salivary sparing
    David I Rosenthal
    The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Semin Oncol 31:25-8. 2004

Detail Information

Publications88

  1. ncbi Sinonasal neuroendocrine carcinoma: impact of differentiation status on response and outcome
    Anna Likhacheva
    Department of Radian Oncology, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX 77030, USA
    Head Neck Oncol 3:32. 2011
    ..The impact of tumor differentiation on the behavior and response of sinonasal neuroendocrine carcinoma is unknown...
  2. ncbi Head and neck squamous cell carcinoma: optimizing the therapeutic index
    David I Rosenthal
    Department of Radiation Oncology, 097, The University of Texas, MD Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030 4009, USA
    Expert Rev Anticancer Ther 5:501-14. 2005
    ..These strategies are reviewed in a clinical context...
  3. ncbi Prevention and treatment of dysphagia and aspiration after chemoradiation for head and neck cancer
    David I Rosenthal
    Department of Head and Neck Surgery, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    J Clin Oncol 24:2636-43. 2006
    ..Specific recommendations are made to promote maintenance and recovery of swallowing function...
  4. ncbi Early postoperative paclitaxel followed by concurrent paclitaxel and cisplatin with radiation therapy for patients with resected high-risk head and neck squamous cell carcinoma: report of the phase II trial RTOG 0024
    David I Rosenthal
    Department of Radiation Oncology, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    J Clin Oncol 27:4727-32. 2009
    ....
  5. ncbi Phase I study of Paclitaxel given by seven-week continuous infusion concurrent with radiation therapy for locally advanced non-small cell lung cancer
    David I Rosenthal
    Department of Radiation Oncology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    J Thorac Oncol 1:38-45. 2006
    ....
  6. ncbi Phase I study of preoperative radiation therapy with concurrent infusional 5-fluorouracil and oxaliplatin followed by surgery and postoperative 5-fluorouracil plus leucovorin for T3/T4 rectal adenocarcinoma: ECOG E1297
    David I Rosenthal
    Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA
    Int J Radiat Oncol Biol Phys 72:108-13. 2008
    ..We performed a Phase I trial to test the safety and preliminary efficacy of adding oxaliplatin to standard preoperative chemoradiation therapy for rectal cancer...
  7. ncbi Simple carotid-sparing intensity-modulated radiotherapy technique and preliminary experience for T1-2 glottic cancer
    David I Rosenthal
    Department of Radiation Oncology, University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Int J Radiat Oncol Biol Phys 77:455-61. 2010
    ..To investigate the dosimetry and feasibility of carotid-sparing intensity-modulated radiotherapy (IMRT) for early glottic cancer and to report preliminary clinical experience...
  8. ncbi Strategies for managing radiation-induced mucositis in head and neck cancer
    David I Rosenthal
    Department of Radiation Oncology, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Semin Radiat Oncol 19:29-34. 2009
    ..This review focuses on mucositis recognition, patient treatment selection, and RIM symptom-management strategies...
  9. ncbi Sinonasal malignancies with neuroendocrine differentiation: patterns of failure according to histologic phenotype
    David I Rosenthal
    Department of Radiation Oncology, The University of Texas M D Anderson Cancer Center, Houston, Texas, USA
    Cancer 101:2567-73. 2004
    ..The authors reviewed their institutional experience to determine whether sinonasal neuroendocrine tumors of different histologies have distinct clinical characteristics that warrant individualized treatment approaches...
  10. ncbi A phase II study to assess the efficacy of amifostine for submandibular/sublingual salivary sparing during the treatment of head and neck cancer with intensity modulated radiation therapy for parotid salivary sparing
    David I Rosenthal
    The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Semin Oncol 31:25-8. 2004
    ....
  11. ncbi Importance of patient examination to clinical quality assurance in head and neck radiation oncology
    David I Rosenthal
    Department of Radiation Oncology, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX 77030, USA
    Head Neck 28:967-73. 2006
    ..We determined the value of clinical peer review in radiation therapy for head and neck cancer that involved head and neck examination...
  12. ncbi Consequences of mucositis-induced treatment breaks and dose reductions on head and neck cancer treatment outcomes
    David I Rosenthal
    Department of Radiation Oncology, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Blvd, Box 0097, Houston, TX 77030, USA
    J Support Oncol 5:23-31. 2007
    ..Effective prophylaxis or treatment could reduce the probability of treatment breaks and dose reductions and thus improve outcomes...
  13. ncbi Measuring head and neck cancer symptom burden: the development and validation of the M. D. Anderson symptom inventory, head and neck module
    David I Rosenthal
    Department of Radiation Oncology, The University of Texas M D Anderson Cancer Center, Houston, Texas, USA
    Head Neck 29:923-31. 2007
    ....
  14. ncbi Hypothyroidism in older patients with head and neck cancer after treatment with radiation: a population-based study
    Grace L Smith
    Department of Radiation Oncology, The University of Texas M D Anderson Cancer Center, Houston, Texas, USA
    Head Neck 31:1031-8. 2009
    ..In patients with head and neck cancer, radiation treatment (RT) is a risk factor for hypothyroidism. However, the specific magnitude of risk after RT in older patients is not known...
  15. ncbi Prospective imaging assessment of mortality risk after head-and-neck radiotherapy
    Benjamin J Moeller
    Department of Radiation Oncology, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
    Int J Radiat Oncol Biol Phys 78:667-74. 2010
    ..Unresolved questions include whether functional or anatomic imaging might improve mortality risk assessment for this disease. We addressed these issues in a prospective institutional trial...
  16. ncbi Patterns of disease recurrence following treatment of oropharyngeal cancer with intensity modulated radiation therapy
    Adam S Garden
    Department of Radiation Oncology, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
    Int J Radiat Oncol Biol Phys 85:941-7. 2013
    ..To report mature results of a large cohort of patients diagnosed with squamous cell carcinoma of the oropharynx who were treated with intensity modulated radiation therapy (IMRT)...
  17. ncbi Outcomes of patients with tonsillar carcinoma treated with post-tonsillectomy radiation therapy
    Gokcen Yildirim
    The University of Texas M D Anderson Cancer Center, Department of Radiation Oncology, Unit 97, 1515 Holcombe Blvd, Houston, TX 77030, USA
    Head Neck 32:473-80. 2010
    ..Our aim was to evaluate the therapeutic outcomes of patients with squamous cell carcinoma of the tonsil that underwent tonsillectomies followed by radiotherapy...
  18. ncbi Candidate dosimetric predictors of long-term swallowing dysfunction after oropharyngeal intensity-modulated radiotherapy
    David L Schwartz
    Department of Radiation Oncology, University of Texas M D Anderson Cancer Center, Houston, TX 77030 4009, USA
    Int J Radiat Oncol Biol Phys 78:1356-65. 2010
    ..To investigate long-term swallowing function in oropharyngeal cancer patients treated with intensity-modulated radiotherapy (IMRT), and to identify novel dose-limiting criteria predictive for dysphagia...
  19. ncbi Survival impact of planned restaging and early surgical salvage following definitive chemoradiation for locally advanced squamous cell carcinomas of the oropharynx and hypopharynx
    Sue S Yom
    Department of Radiation Oncology, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania, USA
    Am J Clin Oncol 28:385-92. 2005
    ..Future efforts may focus on the improved selection of patients who would be most likely to require early surgical intervention...
  20. ncbi Intensity-modulated radiotherapy for cervical node squamous cell carcinoma metastases from unknown head-and-neck primary site: M. D. Anderson Cancer Center outcomes and patterns of failure
    Steven J Frank
    Department of Radiation Oncology, University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Int J Radiat Oncol Biol Phys 78:1005-10. 2010
    ....
  21. ncbi Pilot study of postoperative reirradiation, chemotherapy, and amifostine after surgical salvage for recurrent head-and-neck cancer
    Mitchell Machtay
    Department of Radiation Oncology, University of Pennsylvania Medical Center, Philadelphia, PA, USA
    Int J Radiat Oncol Biol Phys 59:72-7. 2004
    ..We designed a prospective protocol to determine the feasibility, toxicity, and preliminary efficacy of a regimen of postoperative reirradiation, chemotherapy and the radioprotector amifostine after salvage head-and-neck surgery...
  22. ncbi Differential expression of hormonal and growth factor receptors in salivary duct carcinomas: biologic significance and potential role in therapeutic stratification of patients
    Michelle D Williams
    Department of Pathology, The University of Texas M D Anderson Cancer Center, Houston, TX, USA
    Am J Surg Pathol 31:1645-52. 2007
    ....
  23. ncbi The M. D. Anderson symptom inventory-head and neck module, a patient-reported outcome instrument, accurately predicts the severity of radiation-induced mucositis
    David I Rosenthal
    Department of Radiation Oncology, The University of Texas M D Anderson Cancer Center, Houston, TX, USA
    Int J Radiat Oncol Biol Phys 72:1355-61. 2008
    ....
  24. ncbi Unilateral radiotherapy for the treatment of tonsil cancer
    Gregory M Chronowski
    Department of Radiation Oncology, University of Texas M D Anderson Cancer Center, Houston, TX, USA
    Int J Radiat Oncol Biol Phys 83:204-9. 2012
    ..D. Anderson Cancer Center with unilateral radiotherapy techniques that irradiate the involved tonsil region and ipsilateral neck only...
  25. ncbi Prediction of neck dissection requirement after definitive radiotherapy for head-and-neck squamous cell carcinoma
    Juliette Thariat
    Department of Radiation Oncology, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
    Int J Radiat Oncol Biol Phys 82:e367-74. 2012
    ....
  26. ncbi Multiple regions-of-interest analysis of setup uncertainties for head-and-neck cancer radiotherapy
    Lifei Zhang
    Department of Radiation Physics, The University of Texas M. D. Anderson Cancer Center, Houston, TX 77030, USA
    Int J Radiat Oncol Biol Phys 64:1559-69. 2006
    ..CONCLUSIONS: We found variability in setup corrections for different regions of head-and-neck anatomy. These relative positional variations should be considered when making setup corrections or designing treatment margins...
  27. ncbi Disease-control rates following intensity-modulated radiation therapy for small primary oropharyngeal carcinoma
    Adam S Garden
    Division of Radiation Oncology, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Int J Radiat Oncol Biol Phys 67:438-44. 2007
    ....
  28. ncbi Parotid gland dose in intensity-modulated radiotherapy for head and neck cancer: is what you plan what you get?
    Jennifer C O'Daniel
    Department of Radiation Physics, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Int J Radiat Oncol Biol Phys 69:1290-6. 2007
    ..To quantify the differences between planned and delivered parotid gland and target doses, and to assess the benefits of daily bone alignment for head and neck cancer patients treated with intensity-modulated radiotherapy (IMRT)...
  29. ncbi Management of nonsinonasal neuroendocrine carcinomas of the head and neck
    Jerry L Barker
    Department of Radiation Oncology, The University of Texas M. D. Anderson Cancer Center, Houston, Texas 77030, USA
    Cancer 98:2322-8. 2003
    ....
  30. ncbi Postoperative radiotherapy for advanced medullary thyroid cancer--local disease control in the modern era
    David L Schwartz
    Department of Radiation Oncology, The University of Texas M D Anderson Cancer Center, Houston, Texas, USA
    Head Neck 30:883-8. 2008
    ..The purpose of this study is to catalog modern-era postoperative radiotherapy (external beam radiotherapy [EBRT]) outcomes for advanced medullary thyroid cancer...
  31. ncbi Postoperative radiotherapy for maxillary sinus cancer: long-term outcomes and toxicities of treatment
    Ian J Bristol
    Department of Radiation Oncology, University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Int J Radiat Oncol Biol Phys 68:719-30. 2007
    ..To determine the effects of three changes in radiotherapy technique on the outcomes for patients irradiated postoperatively for maxillary sinus cancer...
  32. ncbi Final report of a pilot trial of accelerated radiotherapy plus concurrent 96-hour infusional paclitaxel for locally advanced head and neck cancer
    Mary K Bucci
    Department of Radiation Oncology, University of Pennsylvania Medical Center, Philadelphia, Pennsylvania, USA
    Am J Clin Oncol 27:595-602. 2004
    ..LRC and survival compare favorably with other aggressive regimens for this poor-prognosis population. Further study of accelerated XRT with concurrent chemotherapy is indicated...
  33. ncbi Beam path toxicities to non-target structures during intensity-modulated radiation therapy for head and neck cancer
    David I Rosenthal
    Department of Radiation Oncology, The University of Texas M D Anderson Cancer Center, Houston, TX, USA
    Int J Radiat Oncol Biol Phys 72:747-55. 2008
    ..This study estimates the doses and toxicities to nontarget structures during IMRT...
  34. ncbi Anaplastic thyroid cancer: Clinical outcomes with conformal radiotherapy
    Aarti Bhatia
    Department of Radiation Oncology, The University of Texas M D Anderson Cancer Center, Houston, Texas, USA
    Head Neck 32:829-36. 2010
    ..The aim of this study was to review institutional outcomes for anaplastic thyroid cancer treated with conformal 3-dimensional radiotherapy (3DRT) or intensity-modulated radiotherapy (IMRT)...
  35. ncbi IMRT reirradiation of head and neck cancer-disease control and morbidity outcomes
    Erik P Sulman
    Department of Radiation Oncology, The University of Texas M D Anderson Cancer Center, Houston, TX, USA
    Int J Radiat Oncol Biol Phys 73:399-409. 2009
    ..Limited data are available regarding the use of intensity-modulated radiotherapy (IMRT) for this indication. We reviewed our initial experience using IMRT for previously irradiated head and neck cancer patients...
  36. ncbi Organ preservation therapy using induction plus concurrent chemoradiation for advanced resectable oropharyngeal carcinoma: a University of Pennsylvania Phase II Trial
    Mitchell Machtay
    Department of Radiation Oncology, University of Pennsylvania Medical Center, Philadelphia 19104, USA
    J Clin Oncol 20:3964-71. 2002
    ..To determine the efficacy, feasibility, and toxicity of a new regimen for locally advanced oropharyngeal carcinoma...
  37. ncbi Effect of initial treatment on disease outcome for patients with submandibular gland carcinoma
    Scott M Kaszuba
    Department of Head and Neck Surgery, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Blvd, Unit 441, Houston, TX 77030, USA
    Arch Otolaryngol Head Neck Surg 133:546-50. 2007
    ..To elucidate the effect on outcome of initial surgical enucleation with or without definitive surgical resection and radiation therapy for patients with submandibular gland carcinoma...
  38. ncbi Postoperative external beam radiotherapy for differentiated thyroid cancer: outcomes and morbidity with conformal treatment
    David L Schwartz
    Department of Radiation Oncology, UT MD Anderson Cancer Center, Houston, TX 77030, USA
    Int J Radiat Oncol Biol Phys 74:1083-91. 2009
    ..To review institutional outcomes for patients treated for differentiated thyroid cancer with postoperative conformal external beam radiotherapy (EBRT)...
  39. ncbi The effect of dental artifacts, contrast media, and experience on interobserver contouring variations in head and neck anatomy
    David I Rosenthal
    Department of Radiation Physics, University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Am J Clin Oncol 30:191-8. 2007
    ..To investigate interobserver variability in the delineation of head-and-neck (H&N) anatomic structures on CT images, including the effects of image artifacts and observer experience...
  40. ncbi Quantification of volumetric and geometric changes occurring during fractionated radiotherapy for head-and-neck cancer using an integrated CT/linear accelerator system
    Jerry L Barker
    Department of Radiation Oncology, University of Texas M. D. Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
    Int J Radiat Oncol Biol Phys 59:960-70. 2004
    ..In theory, such a strategy would maximize the therapeutic ratio of RT...
  41. ncbi Compliance with quality assurance measures in patients treated for early oral tongue cancer
    Amy C Hessel
    Department of Head and Neck Surgery, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Cancer 116:3408-16. 2010
    ..The objective of this study was to identify measurable parameters that provide quality data for assessing how well cancer care adheres to accepted treatment guidelines and is delivered to any given patient with oral tongue cancer...
  42. ncbi Outcomes after radiotherapy for squamous cell carcinoma of the eyelid
    Janjira Petsuksiri
    Division of Radiation Oncology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Cancer 112:111-8. 2008
    ..Squamous cell carcinoma (SCC) of the eyelid is a rare malignancy with metastatic potential. In the current study, the outcomes of patients with SCC of the eyelid were evaluated after definitive and postoperative radiation therapy...
  43. ncbi A phase I study of SPI-077 (Stealth liposomal cisplatin) concurrent with radiation therapy for locally advanced head and neck cancer
    David I Rosenthal
    Department of Radiation Oncology, Head and Neck Surgery, Hospital of the University of Pennsylvania, Philadelphia 19104, USA
    Invest New Drugs 20:343-9. 2002
    ..We performed a Phase I study of Stealth liposomal cisplatin (SPI-077) concurrent with RT for head and neck squamous cell carcinoma (HNSCC)...
  44. ncbi Radiation therapy for early-stage carcinoma of the oropharynx
    Ugur Selek
    Department of Radiation Oncology, The University of Texas, M. D. Anderson Cancer Center, Houston, 77030, USA
    Int J Radiat Oncol Biol Phys 59:743-51. 2004
    ..The development of second primary tumors of the UADT adversely impacts survival in these patients to as great a degree as the index cancer...
  45. ncbi Two-field versus three-field irradiation technique in the postoperative treatment of head-and-neck cancer
    Sue S Yom
    Division of Radiation Oncology, The University of Texas M. D. Anderson Cancer Center, Houston, TX 77030, USA
    Int J Radiat Oncol Biol Phys 66:469-76. 2006
    ..Despite its use in more challenging cases, CTT provides similar long-term clinical outcomes compared with standard 3FT, when computerized three-dimensional dosimetry is used to assure adequate dosimetry throughout the treated volume...
  46. ncbi Molecular and clinicopathologic comparisons of head and neck squamous carcinoma variants: common and distinctive features of biological significance
    Hong Ran Choi
    Department of Pathology, The University of Texas M. D. Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
    Am J Surg Pathol 28:1299-310. 2004
    ....
  47. ncbi Target coverage for head and neck cancers treated with IMRT: review of clinical experiences
    Adam S Garden
    Department of Radiation Oncology, The University of Texas, MD Anderson Cancer Center, Houston, TX 77030, USA
    Semin Radiat Oncol 14:103-9. 2004
    ..This review will focus on how IMRT is being implemented into the treatment of head and neck cancer, specifically with regards to target definition and dosing issues...
  48. ncbi Cerebrovascular disease risk in older head and neck cancer patients after radiotherapy
    Grace L Smith
    Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
    J Clin Oncol 26:5119-25. 2008
    ..Cerebrovascular disease is common in head and neck cancer patients, but it is unknown whether radiotherapy increases the cerebrovascular disease risk in this population...
  49. ncbi Sinonasal adenoid cystic carcinoma: the M. D. Anderson Cancer Center experience
    Allison D Lupinetti
    Department of Head and Neck Surgery, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030 4095, USA
    Cancer 110:2726-31. 2007
    ..The objective of the current study was to evaluate prognostic factors, treatment outcomes, recurrence patterns, and survival rates for sinonasal adenoid cystic carcinoma...
  50. ncbi Presence of malignant tumor cells in persistent neck disease after radiotherapy for advanced squamous cell carcinoma of the oropharynx is associated with poor survival
    Christian Simon
    Department of Head and Neck Surgery, The University of Texas Anderson Cancer Center, Houston, TX, USA
    Eur Arch Otorhinolaryngol 263:313-8. 2006
    ....
  51. ncbi New equations for matching a low neck field to oblique upper neck fields with collimator rotation in a 3-field monoisocentric setup for head-and-neck cancers
    Maria A Manske
    Department of Radiation Physics, University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Med Dosim 29:86-91. 2004
    ..They predict the necessary manipulations of the LAN boost field to maintain a geometrically precise matchline, as verified by 3D treatment planning software, phantom dosimetry, and actual patient setups...
  52. ncbi The role of salvage surgery in patients with recurrent squamous cell carcinoma of the oropharynx
    Mark E Zafereo
    Bobby R Alford Department of Otolaryngology Head and Neck Surgery, Baylor College of Medicine, Houston, Texas 77230 1402, USA
    Cancer 115:5723-33. 2009
    ....
  53. ncbi Parathyroid carcinoma: a 22-year experience
    Naifa L Busaidy
    joint Baylor College of Medicine/The University of Texas M. D. Anderson Cancer Center Training Program in Endocrinology, Diabetes, and Metabolism, Houston, Texas, USA
    Head Neck 26:716-26. 2004
    ..A comprehensive multidisciplinary approach with surgery, radiation therapy, and medical treatment for hypercalcemia is needed to optimize patient outcome...
  54. ncbi Preliminary investigation of symptom distress in the head and neck patient population: validation of a measurement instrument
    Heather A Jones
    Department of Radiation Oncology, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
    Am J Clin Oncol 29:158-62. 2006
    ..CONCLUSION: The HNDS is a valid measure of acute symptom distress and appears able to discriminate between the chemoradiation and radiation alone patients. There is considerable variation in symptoms that cause these patients distress...
  55. ncbi Outcomes and patterns of care of patients with locally advanced oropharyngeal carcinoma treated in the early 21st century
    Adam S Garden
    Department of Radiation Oncology, University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Radiat Oncol 8:21. 2013
    ..We performed this study to assess outcomes of patients with oropharyngeal cancer treated with modern therapy approaches...
  56. ncbi Comparison of 2D radiographic images and 3D cone beam computed tomography for positioning head-and-neck radiotherapy patients
    Heng Li
    Department of Radiation Physics, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
    Int J Radiat Oncol Biol Phys 71:916-25. 2008
    ..To assess the benefit of patient-specific headrest...
  57. ncbi Impact of changes to the American Joint Committee on Cancer T classification on outcome prediction in patients with oropharyngeal cancer
    Joshua A Asper
    Department of Radiation Oncology, University of Texas M. D. Anderson Cancer Center, Houston, Texas 77030, USA
    Cancer 106:1950-7. 2006
    ..CONCLUSIONS: The modifications established in the 6th edition of the AJCC tumor staging system for oropharyngeal tumors appear to be useful to distinguish prognostic groups for both LC and OS based on tumor stage...
  58. ncbi Altered radiation therapy fractionation, chemoradiation, and patient selection for the treatment of head and neck squamous carcinoma
    David I Rosenthal
    Department of Radiation Oncology, The University of Texas, MD Anderson Cancer Center, Houston, TX 77030-4009, USA
    Semin Radiat Oncol 14:153-66. 2004
    ..These initiatives will likely lead to improvement in the therapeutic index for patients with HNSCC...
  59. ncbi Acupuncture for radiation-induced xerostomia in patients with cancer: a pilot study
    M Kay Garcia
    Integrative Medicine, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Head Neck 31:1360-8. 2009
    ..This pilot study evaluated if acupuncture can alleviate radiation-induced xerostomia among patients with cancer. Secondary objectives were to assess the effects of acupuncture on salivary flow and quality of life (QOL)...
  60. ncbi Relative risk of stroke in head and neck carcinoma patients treated with external cervical irradiation
    Jeffrey C Haynes
    Department of Radiation Oncology, University of Pennsylvania Medical Center, Philadelphia, Pennsylvania 19104, USA
    Laryngoscope 112:1883-7. 2002
    ..Although the relative risk is approximately doubled, the absolute risk is modest in comparison to the risk of cancer recurrence. Further study of this association and possible interventions is warranted...
  61. ncbi Postoperative adjuvant external-beam radiation therapy for cancers of the eyelid and conjunctiva
    Adam Hsu
    Section of Ophthalmology, and daggerDepartment of Radiation Oncology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Ophthal Plast Reconstr Surg 24:444-9. 2008
    ..To outline the indications for and our experience with postoperative adjuvant external-beam radiotherapy (EBRT) in patients with eyelid or conjunctival cancers...
  62. ncbi Outcomes of malignant tumors of the lacrimal apparatus: the University of Texas MD Anderson Cancer Center experience
    Heath D Skinner
    Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA
    Cancer 117:2801-10. 2011
    ..The purpose of this study was to assess treatment outcomes by type of surgery (orbital exenteration vs eye-sparing surgery) and clarify the role of adjuvant RT for this rare disease...
  63. ncbi Epithelial to mesenchymal transition in head and neck squamous carcinoma: association of Src activation with E-cadherin down-regulation, vimentin expression, and aggressive tumor features
    Mahitosh Mandal
    Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
    Cancer 112:2088-100. 2008
    ..In the current study, the expressions of several factors associated with the induction of EMT in HNSC cell lines and tumor specimens were investigated to define their functional and pathologic role in HNSC...
  64. ncbi Phase II study of palifermin and concurrent chemoradiation in head and neck squamous cell carcinoma
    David M Brizel
    Department of Radiation Oncology, Duke University, Durham, NC, USA
    J Clin Oncol 26:2489-96. 2008
    ..This study assessed the efficacy and safety of palifermin in patients receiving concurrent chemoradiotherapy for advanced head and neck squamous cell carcinoma...
  65. ncbi Molecular and phenotypic analysis of poorly differentiated sinonasal neoplasms: an integrated approach for early diagnosis and classification
    Brett Cordes
    Bobby R Alford Department of Otolaryngology Head and Neck Surgery, Baylor College of Medicine, Houston, TX 77030, USA
    Hum Pathol 40:283-92. 2009
    ....
  66. ncbi Genetic analysis of sinonasal adenocarcinoma phenotypes: distinct alterations of histogenetic significance
    Sue S Yom
    Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
    Mod Pathol 18:315-9. 2005
    ....
  67. ncbi Controversies in the management of advanced laryngeal squamous cell carcinoma
    Randal S Weber
    Department of Head and Neck Surgery, The University of Texas M. D. Anderson Cancer Center, Houston, Texas 77030, USA
    Cancer 101:211-9. 2004
  68. ncbi Prospective risk-adjusted [18F]Fluorodeoxyglucose positron emission tomography and computed tomography assessment of radiation response in head and neck cancer
    Benjamin J Moeller
    Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA
    J Clin Oncol 27:2509-15. 2009
    ..We conducted a prospective trial to identify patient populations likely to benefit from the addition of functional imaging to the assessment of radiotherapy response...
  69. ncbi Radiation-induced xerostomia
    Mark S Chambers
    Department of Head and Neck Surgery, The University of Texas, M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030 4009, USA
    Head Neck 29:58-63. 2007
    ..Radiation-induced xerostomia is a frequent and usually permanent side effect of radiation therapy for head and neck cancer. We summarize recent developments in the prevention and treatment of radiation-induced xerostomia...
  70. ncbi Importance of the treatment package time in surgery and postoperative radiation therapy for squamous carcinoma of the head and neck
    David I Rosenthal
    Department of Radiation Oncology, Hospital of the University of Pennsylvania, 3400 Spruce Street, 2 Donner, Philadelphia, PA 19104, USA
    Head Neck 24:115-26. 2002
    ..CONCLUSIONS: A total treatment package time of <100 days is associated with improved tumor control and survival. Every effort should be made to keep the time from surgery to the completion of postoperative RT to <100 days...
  71. ncbi Does concurrent postoperative radiotherapy and chemotherapy in head and neck cancer improve patient outcome?
    Sue S Yom
    Department of Radiation Oncology, The University of Texas M D Anderson Cancer Center, Houston 77030, USA
    Nat Clin Pract Oncol 1:14-5. 2004
  72. ncbi Local recurrence in head and neck cancer: relationship to radiation resistance and signal transduction
    Anjali K Gupta
    Department of Radiation Oncology, University of Pennsylvania, Philadelphia, Pennsylvania 19104 6072, USA
    Clin Cancer Res 8:885-92. 2002
    ..We have shown previously that radioresistance could be conferred via the Ras-PI3K pathway. Here we investigate the contribution of EGFR to this pathway and its impact on treatment outcome...
  73. ncbi Swallowing outcomes after radiotherapy for laryngeal carcinoma
    Katherine A Hutcheson
    Department of Head and Neck Surgery, University of Texas M D Anderson Cancer Center, Houston, TX 77030 4009, USA
    Arch Otolaryngol Head Neck Surg 134:178-83. 2008
    ..To describe swallowing physiology and functional outcomes at select intervals after definitive radiotherapy for laryngeal carcinoma. We also examined associations among patient, tumor, and treatment characteristics and swallowing outcomes...
  74. ncbi Conditional survival in head and neck squamous cell carcinoma: results from the SEER dataset 1973-1998
    Clifton D Fuller
    Department of Radiation Oncology and Graduate Division of Radiological Sciences, University of Texas Health Science Center at San Antonio, San Antonio, Texas, USA
    Cancer 109:1331-43. 2007
    ..Useful prognostic information for cancer survivors is provided by CS analysis. Estimated baseline CS parameters for HNSCC were sought using large-scale cancer registry data...
  75. ncbi Differential methylation status of tumor-associated genes in head and neck squamous carcinoma: incidence and potential implications
    Shin-Ichiro Maruya
    Department of Pathology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Clin Cancer Res 10:3825-30. 2004
    ..The variability within and between cell lines and tumor specimens supports a heterogeneous and dynamic state of methylation in genes associated with HNSC tumorigenesis...
  76. ncbi Sinonasal teratocarcinosarcoma of the head and neck: a report of 10 patients treated at a single institution and comparison with reported series
    Stacey L Smith
    Department of Head and Neck Surgery, The University of Texas Medical School, Houston, TX, USA
    Arch Otolaryngol Head Neck Surg 134:592-5. 2008
    ..Previous reports of these tumors have focused on their differential diagnosis and histogenesis and consisted of individual case reports and consultation based series...
  77. ncbi Prediction of treatment response of head and neck cancers with P-31 MR spectroscopy from pretreatment relative phosphomonoester levels
    Amita Shukla-Dave
    Dept of Radiology, University of Pennsylvania Medical Center, Philadelphia, USA
    Acad Radiol 9:688-94. 2002
    ..0 +/- 0.0 vs 1.22 +/- 0.17 [P = .004]). CONCLUSION: Results of this preliminary study suggest that H-1-decoupled P-31 magnetic resonance spectroscopy may prove to be a useful predictor of therapeutic response in head and neck cancers...
  78. ncbi Parotidectomy in the treatment of aggressive cutaneous malignancies
    Stephen Y Lai
    Department of Otorhinolaryngology-Head and Neck Surgery, University of Pennsylvania Medical Center, 5 Silverstein/Ravdin, 3400 Spruce St, Philadelphia, PA 19104, USA
    Arch Otolaryngol Head Neck Surg 128:521-6. 2002
    ..A systematic approach to the management of the parotid and facial nerve in the presence of these aggressive tumors is required. Despite comprehensive treatment, local recurrence of ANMSC and mortality remain high...
  79. ncbi Reinterpretation of cross-sectional images in patients with head and neck cancer in the setting of a multidisciplinary cancer center
    Laurie A Loevner
    Department of Radiology, University of Pennsylvania School of Medicine, University of Pennsylvania Medical Center, Philadelphia, PA 19104, USA
    AJNR Am J Neuroradiol 23:1622-6. 2002
    ..001). CONCLUSION: Reinterpretation of cross-sectional images in the setting of a multidisciplinary cancer center has a significant effect on staging, management, and prognosis in patients with head and neck cancer...
  80. ncbi Comparison of stages I-II thymoma treated by complete resection with or without adjuvant radiation
    Sunil Singhal
    Section of General Thoracic Surgery, Division of Cardiothoracic Surgery, Department of Surgery, Pennsylvania, Philadelphia, USA
    Ann Thorac Surg 76:1635-41; discussion 1641-2. 2003
    ..32) between the radiated and unradiated groups. CONCLUSIONS: These data support the contention that margin-negative surgical resection alone is sufficient treatment for both stages I and II thymoma...
  81. ncbi A multinational, randomized phase III trial of iseganan HCl oral solution for reducing the severity of oral mucositis in patients receiving radiotherapy for head-and-neck malignancy
    Andy Trotti
    Radiation Oncology Program, H Lee Moffitt Cancer Center at the University of South Florida, Tampa, FL, USA
    Int J Radiat Oncol Biol Phys 58:674-81. 2004
    ..It is hypothesized that infection plays a role in the development of OM. We tested the efficacy of iseganan HCl (iseganan), a synthetic peptide with broad-spectrum antimicrobial activity, for preventing RT-associated OM...
  82. ncbi Postoperative treatment intensification for improving outcome in the high-risk patient: an evolutionary process
    Randal S Weber
    Head Neck 27:841-2. 2005
  83. ncbi Established and emerging uses of cytoprotection in head and neck cancer
    David I Rosenthal
    Arch Otolaryngol Head Neck Surg 132:129-30. 2006
  84. ncbi A Phase II trial of subcutaneous amifostine and radiation therapy in patients with head-and-neck cancer
    Pramila Rani Anne
    Thomas Jefferson University Hospital, Bodine Center for Cancer Research, Philadelphia, PA 19107, USA
    Int J Radiat Oncol Biol Phys 67:445-52. 2007
    ..Intravenous amifostine 200 mg/m2 reduces xerostomia in head-and-neck cancer patients. This Phase II study evaluated subcutaneous (s.c.) amifostine in a similar patient population...
  85. ncbi Phase II trial of chemoradiation for organ preservation in resectable stage III or IV squamous cell carcinomas of the larynx or oropharynx: results of Eastern Cooperative Oncology Group Study E2399
    Anthony J Cmelak
    Vanderbilt University Medical Center, Nashville, TN 37232 5671, USA
    J Clin Oncol 25:3971-7. 2007
    ..This phase II multi-institutional trial evaluates taxane-based induction chemotherapy followed by CCR for organ preservation in resectable stage III/IVA and IVB larynx and oropharynx (OP) cancer patients...
  86. ncbi Increasing toxicity in nonoperative head and neck cancer treatment: investigations and interventions
    Søren M Bentzen
    University of Wisconsin School of Medicine and Public Health, Madison, WI 53792, USA
    Int J Radiat Oncol Biol Phys 69:S79-82. 2007
  87. ncbi Sarcomatoid carcinoma of the head and neck: molecular evidence for evolution and progression from conventional squamous cell carcinomas
    Hong-Ran Choi
    Department of Pathology, University of Texas M. D. Anderson Cancer Center, Houston, 77030, USA
    Am J Surg Pathol 27:1216-20. 2003
    ..Our study supports: 1) an evolution of sarcomatoid carcinoma from the conventional epithelial-type, 2) a malignant nature of the sarcomatoid component, and 3) that molecular progression is associated with the sarcomatoid transformation...
  88. ncbi Pre-analytic saliva processing affect proteomic results and biomarker screening of head and neck squamous carcinoma
    Kazufumi Ohshiro
    Department of Pathology, The University of Texas, M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
    Int J Oncol 30:743-9. 2007
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