Hugh Rosen


Affiliation: The Scripps Research Institute
Country: USA


  1. Sanna M, Vincent K, Repetto E, Nguyen N, Brown S, Abgaryan L, et al. Bitopic Sphingosine 1-Phosphate Receptor 3 (S1P3) Antagonist Rescue from Complete Heart Block: Pharmacological and Genetic Evidence for Direct S1P3 Regulation of Mouse Cardiac Conduction. Mol Pharmacol. 2016;89:176-86 pubmed publisher
    ..A richer understanding of receptor and ligand usage in the pacemaker cells of the cardiac system is likely to be useful in understanding ventricular conduction in health, disease, and pharmacology. ..
  2. Sarkisyan G, Gay L, Nguyen N, Felding B, Rosen H. Host endothelial S1PR1 regulation of vascular permeability modulates tumor growth. Am J Physiol Cell Physiol. 2014;307:C14-24 pubmed publisher
    ..Regulation of endothelial S1PR1 dynamically controls vascular integrity and maturation and thus modulates angiogenesis, tumor growth, and hematogenous metastasis. ..
  3. Rosen H, Alfonso C, Surh C, McHeyzer Williams M. Rapid induction of medullary thymocyte phenotypic maturation and egress inhibition by nanomolar sphingosine 1-phosphate receptor agonist. Proc Natl Acad Sci U S A. 2003;100:10907-12 pubmed
    ..Inhibition of lymphocyte egress from thymus and lymph node can contribute synergistically to clinically useful immunosupression by disrupting recirculation of peripheral T cells. ..
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    Rosen H, Sanna G, Alfonso C. Egress: a receptor-regulated step in lymphocyte trafficking. Immunol Rev. 2003;195:160-77 pubmed
    ..This inhibition induces significant immunosuppression in models of transplantation and autoimmune tissue damage that may prove to be of clinical benefit. ..
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    Rosen H, Sanna M, Cahalan S, Gonzalez Cabrera P. Tipping the gatekeeper: S1P regulation of endothelial barrier function. Trends Immunol. 2007;28:102-7 pubmed
  6. Rosen H, Gonzalez Cabrera P, Marsolais D, Cahalan S, Don A, Sanna M. Modulating tone: the overture of S1P receptor immunotherapeutics. Immunol Rev. 2008;223:221-35 pubmed publisher
  7. Rosen H, Gonzalez Cabrera P, Sanna M, Brown S. Sphingosine 1-phosphate receptor signaling. Annu Rev Biochem. 2009;78:743-68 pubmed publisher