Fredika Robertson

Summary

Affiliation: The University of Texas
Country: USA

Publications

  1. pmc The paradox of E-cadherin: role in response to hypoxia in the tumor microenvironment and regulation of energy metabolism
    Khoi Chu
    Department of Experimental Therapeutics, The University of Texas MD Anderson Cancer Center, Houston, TX, USA
    Oncotarget 4:446-62. 2013
  2. ncbi request reprint The class I HDAC inhibitor Romidepsin targets inflammatory breast cancer tumor emboli and synergizes with paclitaxel to inhibit metastasis
    Fredika M Robertson
    Department of Experimental Therapeutics, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    J Exp Ther Oncol 10:219-33. 2013
  3. doi request reprint Imaging and analysis of 3D tumor spheroids enriched for a cancer stem cell phenotype
    Fredika M Robertson
    The Department of Experimental Therapeutics, University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    J Biomol Screen 15:820-9. 2010
  4. pmc Differential regulation of the aggressive phenotype of inflammatory breast cancer cells by prostanoid receptors EP3 and EP4
    Fredika M Robertson
    Department of Experimental Therapeutics, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Cancer 116:2806-14. 2010
  5. ncbi request reprint Suberoylanilide hydroxamic acid blocks self-renewal and homotypic aggregation of inflammatory breast cancer spheroids
    Fredika M Robertson
    The Morgan Welch Inflammatory Breast Cancer Research Program, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Cancer 116:2760-7. 2010
  6. ncbi request reprint High-Content Analysis--CHI's Seventh Annual Conference--Developments in HCA and Pathway Analysis
    Fredika M Robertson
    University of Texas MD Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
    IDrugs 13:149-52. 2010
  7. ncbi request reprint Cyclooxygenase-2 directly induces MCF-7 breast tumor cells to develop into exponentially growing, highly angiogenic and regionally invasive human ductal carcinoma xenografts
    Fredika M Robertson
    Department of Experimental Therapeutics, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Anticancer Res 27:719-27. 2007
  8. ncbi request reprint Molecular and pharmacological blockade of the EP4 receptor selectively inhibits both proliferation and invasion of human inflammatory breast cancer cells
    Fredika M Robertson
    Department of Experimental Therapeutics, 1515 Holcombe Blvd, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    J Exp Ther Oncol 7:299-312. 2008
  9. pmc Differential radiosensitizing effect of valproic acid in differentiation versus self-renewal promoting culture conditions
    Bisrat G Debeb
    Division of Radiation Oncology, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
    Int J Radiat Oncol Biol Phys 76:889-95. 2010
  10. pmc Characterizing cancer cells with cancer stem cell-like features in 293T human embryonic kidney cells
    Bisrat G Debeb
    Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA
    Mol Cancer 9:180. 2010

Research Grants

Collaborators

Detail Information

Publications18

  1. pmc The paradox of E-cadherin: role in response to hypoxia in the tumor microenvironment and regulation of energy metabolism
    Khoi Chu
    Department of Experimental Therapeutics, The University of Texas MD Anderson Cancer Center, Houston, TX, USA
    Oncotarget 4:446-62. 2013
    ..Our data suggests a novel function for E-Cadherin as a bona fide signaling molecule required for the in vivo growth of aggressive breast cancer tumor cells, that retain E-Cadherin expression, in mediating their metabolic function...
  2. ncbi request reprint The class I HDAC inhibitor Romidepsin targets inflammatory breast cancer tumor emboli and synergizes with paclitaxel to inhibit metastasis
    Fredika M Robertson
    Department of Experimental Therapeutics, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    J Exp Ther Oncol 10:219-33. 2013
    ..Furthermore, Romidepsin, in combination with a taxane, warrants evaluation as a therapeutic strategy that may effectively target the skin involvement and rapid metastasis that are hallmarks of IBC...
  3. doi request reprint Imaging and analysis of 3D tumor spheroids enriched for a cancer stem cell phenotype
    Fredika M Robertson
    The Department of Experimental Therapeutics, University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    J Biomol Screen 15:820-9. 2010
    ....
  4. pmc Differential regulation of the aggressive phenotype of inflammatory breast cancer cells by prostanoid receptors EP3 and EP4
    Fredika M Robertson
    Department of Experimental Therapeutics, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Cancer 116:2806-14. 2010
    ....
  5. ncbi request reprint Suberoylanilide hydroxamic acid blocks self-renewal and homotypic aggregation of inflammatory breast cancer spheroids
    Fredika M Robertson
    The Morgan Welch Inflammatory Breast Cancer Research Program, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Cancer 116:2760-7. 2010
    ....
  6. ncbi request reprint High-Content Analysis--CHI's Seventh Annual Conference--Developments in HCA and Pathway Analysis
    Fredika M Robertson
    University of Texas MD Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
    IDrugs 13:149-52. 2010
    ..This conference report highlights selected presentations on the use of HCA for the characterization of stem cells, cell-colony analysis, the validation of disease models and the identification of antiparasitic compounds...
  7. ncbi request reprint Cyclooxygenase-2 directly induces MCF-7 breast tumor cells to develop into exponentially growing, highly angiogenic and regionally invasive human ductal carcinoma xenografts
    Fredika M Robertson
    Department of Experimental Therapeutics, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Anticancer Res 27:719-27. 2007
    ....
  8. ncbi request reprint Molecular and pharmacological blockade of the EP4 receptor selectively inhibits both proliferation and invasion of human inflammatory breast cancer cells
    Fredika M Robertson
    Department of Experimental Therapeutics, 1515 Holcombe Blvd, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    J Exp Ther Oncol 7:299-312. 2008
    ..This is the first report using both a selective pharmacologic inhibitor and a molecular shRNA knockdown approach to demonstrate that EP4 is directly involved in regulation of proliferation and invasion of IBC cells...
  9. pmc Differential radiosensitizing effect of valproic acid in differentiation versus self-renewal promoting culture conditions
    Bisrat G Debeb
    Division of Radiation Oncology, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
    Int J Radiat Oncol Biol Phys 76:889-95. 2010
    ..From these data, we hypothesized that VA would fail to radiosensitize breast cancer stem/progenitor cells grown to three-dimensional (3D) mammospheres...
  10. pmc Characterizing cancer cells with cancer stem cell-like features in 293T human embryonic kidney cells
    Bisrat G Debeb
    Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA
    Mol Cancer 9:180. 2010
    ..Herein we fully characterize cancer stem cell-like features in 293T human embryonic kidney cells...
  11. pmc Different gene expressions are associated with the different molecular subtypes of inflammatory breast cancer
    Takayuki Iwamoto
    Breast Cancer Translational Research Laboratory, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
    Breast Cancer Res Treat 125:785-95. 2011
    ..IBC tumors can be divided into molecular and clinical subtypes similar to those of non-IBC. Clinical subtypes of IBC show molecular differences compared with similar subtypes of non-IBC...
  12. ncbi request reprint Invasive and angiogenic phenotype of MCF-7 human breast tumor cells expressing human cyclooxygenase-2
    Jenifer R Prosperi
    Department of Molecular Virology, Immunology, and Medical Genetics, The Ohio State University Comprehensive Cancer Center, The Ohio State University College of Medicine and Public Health, Columbus OH 43210, USA
    Prostaglandins Other Lipid Mediat 73:249-64. 2004
    ..These results demonstrate that hCox-2 directly increases breast tumor cell proliferation, stimulates invasion across a basement membrane, and induces synthesis of specific heparin binding splice variants of VEGF...
  13. ncbi request reprint The expression of Exonuclease III from E. coli in mitochondria of breast cancer cells diminishes mitochondrial DNA repair capacity and cell survival after oxidative stress
    Inna N Shokolenko
    Department of Cell Biology, University of South Alabama College of Medicine, Mobile, AL 36688, USA
    DNA Repair (Amst) 2:471-82. 2003
    ..This diminished mtDNA repair capacity rendered MDA-MB-231 cells more sensitive to oxidative damage, which resulted in a decrease in their long-term survival following oxidative stress...
  14. ncbi request reprint Cyclooxygenase-2 directly regulates gene expression of P450 Cyp19 aromatase promoter regions pII, pI.3 and pI.7 and estradiol production in human breast tumor cells
    Jenifer R Prosperi
    Department of Molecular Virology, Immunology, and Medical Genetics, The Integrated Biomedical Science Graduate Program, The Ohio State University College of Medicine, 2184 Graves Hall, 333 West 10th Avenue, Columbus, OH 43210, USA
    Prostaglandins Other Lipid Mediat 81:55-70. 2006
    ..In addition, the unique human breast tumor cell model used in these studies may be a useful tool in identifying the spectrum of activities of agents that block the biological effects of PGE2 and estradiol...
  15. ncbi request reprint Activation of Akt and mTOR in CD34+/K15+ keratinocyte stem cells and skin tumors during multi-stage mouse skin carcinogenesis
    Nesrine I Affara
    Department of Molecular Virology, Immunology, and Medical Genetics, The Ohio State University, Columbus, OH 43210, USA
    Anticancer Res 26:2805-20. 2006
    ..The cell populations examined included mouse keratinocyte stem cells (KSCs) within hair follicles and preneoplastic papilloma cells...
  16. ncbi request reprint Vascular endothelial growth factor as a survival factor in tumor-associated angiogenesis
    Nesrine I Affara
    Department of Molecular Virology, Immunology, and Medical Genetics, The Ohio State University, Columbus, OH 43210, USA
    In Vivo 18:525-42. 2004
    ....
  17. ncbi request reprint Endostatin inhibits migration and invasion of head and neck squamous cell carcinoma cells
    Ralph F Wilson
    Departments of Oral Maxillofacial Surgery and Pathology and Periodontology, College of Dentistry, Ohio State University, Columbus, Ohio, USA
    Anticancer Res 23:1289-95. 2003
    ..Our data imply that endostatin's clinical efficacy extends beyond angiostatic properties to encompass a direct anti-tumorigenic effect against HNSCC cells...
  18. ncbi request reprint AIDS-related Kaposi's sarcoma cells rapidly internalize endostatin, which co-localizes to tropomysin microfilaments and inhibits cytokine-mediated migration and invasion
    Susan R Mallery
    Department of Oral Maxillofacial Surgery and Pathology, College of Dentistry, Ohio State University, Columbus 43218, USA
    J Cell Biochem 89:133-43. 2003
    ..As a consequence of its combined angiostatic and antitumorigenic activities, endostatin could provide dual therapeutic benefits for patients with mucocutaneous KS...

Research Grants5

  1. GENE SPECIFIC MUTATIONS IN SKIN INDUCED BY PEROXYNITRITE
    Fredika Robertson; Fiscal Year: 1999
    ..The hypothesis driving this research is that NO and peroxynitrite are mutagenic, and could be important contributors to oxidative DNA damage and mutation in human epidermal keratinocytes at sites of inflammation. ..
  2. GENE SPECIFIC MUTATIONS IN SKIN INDUCED BY PEROXYNITRITE
    Fredika Robertson; Fiscal Year: 2000
    ..The hypothesis driving this research is that NO and peroxynitrite are mutagenic, and could be important contributors to oxidative DNA damage and mutation in human epidermal keratinocytes at sites of inflammation. ..
  3. GENE SPECIFIC MUTATIONS IN SKIN INDUCED BY PEROXYNITRITE
    Fredika Robertson; Fiscal Year: 2001
    ..The hypothesis driving this research is that NO and peroxynitrite are mutagenic, and could be important contributors to oxidative DNA damage and mutation in human epidermal keratinocytes at sites of inflammation. ..