Timothy P Roberts

Summary

Affiliation: The Children's Hospital of Philadelphia
Country: USA

Publications

  1. doi request reprint Developmental correlation of diffusion anisotropy with auditory-evoked response
    Timothy P L Roberts
    Lurie Family Foundations MEG Imaging Center, Department of Radiology, Children s Hospital of Philadelphia, Philadelphia, Pennsylvania 19104, USA
    Neuroreport 20:1586-91. 2009
  2. doi request reprint Maturational differences in thalamocortical white matter microstructure and auditory evoked response latencies in autism spectrum disorders
    Timothy P L Roberts
    Lurie Family Foundation s MEG Imaging Center, Department of Radiology, The Children s Hospital of Philadelphia, Wood Building, Suite 2115, 34th Street and Civic Center Boulevard, Philadelphia, PA, USA Electronic address
    Brain Res 1537:79-85. 2013
  3. pmc Delayed magnetic mismatch negativity field, but not auditory M100 response, in specific language impairment
    Timothy P L Roberts
    Department of Radiology, Children s Hospital of Philadelphia, Wood Bldg Suite 2115, 34th St, Philadelphia, PA 19104, USA
    Neuroreport 23:463-8. 2012
  4. ncbi request reprint Principles and implementation of diffusion-weighted and diffusion tensor imaging
    Timothy P L Roberts
    Department of Radiology, The Children s Hospital of Philadelphia, University of Pennsylvania School of Medicine, 324 S 34th St and Civic Center Blvd, Philadelphia, PA 19104, USA
    Pediatr Radiol 37:739-48. 2007
  5. pmc Electrophysiological signatures: magnetoencephalographic studies of the neural correlates of language impairment in autism spectrum disorders
    Timothy P L Roberts
    Department of Radiology, Children s Hospital of Philadelphia, Philadelphia, PA 19104, United States
    Int J Psychophysiol 68:149-60. 2008
  6. pmc MEG detection of delayed auditory evoked responses in autism spectrum disorders: towards an imaging biomarker for autism
    Timothy P L Roberts
    Department of Radiology, The Children s Hospital of Philadelphia, 34th St and Civic Center Blvd, Philadelphia, PA 19104, USA
    Autism Res 3:8-18. 2010
  7. pmc Auditory magnetic mismatch field latency: a biomarker for language impairment in autism
    Timothy P L Roberts
    Lurie Family Foundations MEG Imaging Center, Department of Radiology, 34th Street and Civic Center Boulevard, Philadelphia, PA 19104, USA
    Biol Psychiatry 70:263-9. 2011
  8. pmc Absence of M100 source asymmetry in autism associated with language functioning
    Gwenda L Schmidt
    Department of Radiology, Children s Hospital of Philadelphia, University of Pennsylvania, Philadelphia, Pennsylvania, USA
    Neuroreport 20:1037-41. 2009
  9. ncbi request reprint Cortical sound processing in children with autism disorder: an MEG investigation
    Nicole M Gage
    Biomagnetic Imaging Laboratory, Department of Radiology, University of California, Irvine, CA 92697 5100, USA
    Neuroreport 14:2047-51. 2003
  10. doi request reprint Knockout of NMDA receptors in parvalbumin interneurons recreates autism-like phenotypes
    John A Saunders
    Translational Neuroscience Program, Department of Psychiatry, University of Pennsylvania, Philadelphia, PA 19104, USA
    Autism Res 6:69-77. 2013

Collaborators

Detail Information

Publications40

  1. doi request reprint Developmental correlation of diffusion anisotropy with auditory-evoked response
    Timothy P L Roberts
    Lurie Family Foundations MEG Imaging Center, Department of Radiology, Children s Hospital of Philadelphia, Philadelphia, Pennsylvania 19104, USA
    Neuroreport 20:1586-91. 2009
    ....
  2. doi request reprint Maturational differences in thalamocortical white matter microstructure and auditory evoked response latencies in autism spectrum disorders
    Timothy P L Roberts
    Lurie Family Foundation s MEG Imaging Center, Department of Radiology, The Children s Hospital of Philadelphia, Wood Building, Suite 2115, 34th Street and Civic Center Boulevard, Philadelphia, PA, USA Electronic address
    Brain Res 1537:79-85. 2013
    ....
  3. pmc Delayed magnetic mismatch negativity field, but not auditory M100 response, in specific language impairment
    Timothy P L Roberts
    Department of Radiology, Children s Hospital of Philadelphia, Wood Bldg Suite 2115, 34th St, Philadelphia, PA 19104, USA
    Neuroreport 23:463-8. 2012
    ....
  4. ncbi request reprint Principles and implementation of diffusion-weighted and diffusion tensor imaging
    Timothy P L Roberts
    Department of Radiology, The Children s Hospital of Philadelphia, University of Pennsylvania School of Medicine, 324 S 34th St and Civic Center Blvd, Philadelphia, PA 19104, USA
    Pediatr Radiol 37:739-48. 2007
    ..This in turn leads to the methodological application of diffusion tensor imaging and the subsequent postprocessing, known as tractography. The following articles deal with the clinical applications enabled by such methodologies...
  5. pmc Electrophysiological signatures: magnetoencephalographic studies of the neural correlates of language impairment in autism spectrum disorders
    Timothy P L Roberts
    Department of Radiology, Children s Hospital of Philadelphia, Philadelphia, PA 19104, United States
    Int J Psychophysiol 68:149-60. 2008
    ..These findings offer promise for the comprehensive assessment of developmental neuropsychiatric disorders...
  6. pmc MEG detection of delayed auditory evoked responses in autism spectrum disorders: towards an imaging biomarker for autism
    Timothy P L Roberts
    Department of Radiology, The Children s Hospital of Philadelphia, 34th St and Civic Center Blvd, Philadelphia, PA 19104, USA
    Autism Res 3:8-18. 2010
    ..Given similar findings in language impaired and non-language impaired ASD subjects, a right-hemisphere M100 latency delay appears to be an electrophysiological endophenotype for autism...
  7. pmc Auditory magnetic mismatch field latency: a biomarker for language impairment in autism
    Timothy P L Roberts
    Lurie Family Foundations MEG Imaging Center, Department of Radiology, 34th Street and Civic Center Boulevard, Philadelphia, PA 19104, USA
    Biol Psychiatry 70:263-9. 2011
    ..The present study assessed associations between language impairment and the amplitude and latency of the superior temporal gyrus magnetic mismatch field (MMF) in response to changes in an auditory stream of tones or vowels...
  8. pmc Absence of M100 source asymmetry in autism associated with language functioning
    Gwenda L Schmidt
    Department of Radiology, Children s Hospital of Philadelphia, University of Pennsylvania, Philadelphia, Pennsylvania, USA
    Neuroreport 20:1037-41. 2009
    ..An association was found between language functioning and the degree of asymmetry across the two groups of children, suggesting a possible relationship between functional-structural asymmetry and language ability...
  9. ncbi request reprint Cortical sound processing in children with autism disorder: an MEG investigation
    Nicole M Gage
    Biomagnetic Imaging Laboratory, Department of Radiology, University of California, Irvine, CA 92697 5100, USA
    Neuroreport 14:2047-51. 2003
    ..Children with autism had a much reduced range of modulation in right hemisphere sites. Findings indicate that frequency encoding mechanisms may follow a differential maturational path in autism spectrum disorder...
  10. doi request reprint Knockout of NMDA receptors in parvalbumin interneurons recreates autism-like phenotypes
    John A Saunders
    Translational Neuroscience Program, Department of Psychiatry, University of Pennsylvania, Philadelphia, PA 19104, USA
    Autism Res 6:69-77. 2013
    ..Autism Res 2013, 6: 69-77. © 2013 International Society for Autism Research, Wiley Periodicals, Inc. ..
  11. doi request reprint Magnetoencephalography
    Erin Simon Schwartz
    Lurie Family Foundations MEG Imaging Center, Department of Radiology, The Children s Hospital of Philadelphia, Philadelphia, PA, USA
    Pediatr Radiol 40:50-8. 2010
    ..Research applications that appear promising for near-future clinical translation include the evaluation of children with autism spectrum disorder, traumatic brain injury, and schizophrenia...
  12. doi request reprint NMDA antagonist MK801 recreates auditory electrophysiology disruption present in autism and other neurodevelopmental disorders
    John A Saunders
    Translational Neuroscience Program, Department of Psychiatry, University of Pennsylvania, Philadelphia, PA 19104, United States
    Behav Brain Res 234:233-7. 2012
    ..Such observations could be important for developing novel therapeutics, as electrophysiological endophenotypes associate with functional measures and may provide early biomarkers for efficacy in clinical trials...
  13. ncbi request reprint Hemispheric asymmetries in auditory evoked neuromagnetic fields in response to place of articulation contrasts
    Nicole M Gage
    Biomagnetic Imaging Laboratory, Department of Radiology, University of California, San Francisco, CA, USA
    Brain Res Cogn Brain Res 14:303-6. 2002
    ..We report differential activation patterns in M100 latency, with larger differences in the right hemisphere than the left. These findings suggest that left and right auditory fields make differential contributions to speech processing...
  14. ncbi request reprint DTI based diagnostic prediction of a disease via pattern classification
    Madhura Ingalhalikar
    Section of Biomedical Image Analysis, University of Pennsylvania, Philadelphia, PA, USA
    Med Image Comput Comput Assist Interv 13:558-65. 2010
    ..58% classification accuracy was obtained. The abnormality scores clearly separate the groups and the high classification accuracy indicates the prospect of using the scores as a diagnostic and prognostic marker...
  15. ncbi request reprint Consistency of interictal and ictal onset localization using magnetoencephalography in patients with partial epilepsy
    Lilly Tang
    Department of Radiology, University of California at San Francisco, California, USA
    J Neurosurg 98:837-45. 2003
    ....
  16. ncbi request reprint Increased somatosensory neuromagnetic fields ipsilateral to lesions in neurosurgical patients
    Timothy P L Roberts
    Box 0628, Biomagnetic Imaging Laboratory, Department of Radiology, University of California, San Francisco 94143, USA
    Neuroreport 13:699-702. 2002
    ..Biophysical and biochemical explanations implicate hyperactivity of cortical neurons close to the tumor, suggesting a possible role of MEG as a measure of tumor infiltration...
  17. ncbi request reprint Carotid stent delivery in an XMR suite: immediate assessment of the physiologic impact of extracranial revascularization
    Alastair J Martin
    Department of Radiology, University of California San Francisco, San Francisco, CA 94143, USA
    AJNR Am J Neuroradiol 26:531-7. 2005
    ..MR imaging was performed before and immediately following conventional radiography-guided stent placement. Changes in MR imaging measurable properties, including flow and perfusion, resulting from stent placement were evaluated...
  18. ncbi request reprint Delayed mismatch field for speech and non-speech sounds in children with autism
    Janis E Oram Cardy
    Department of Medical Imaging, University of Toronto, Toronto, Ontario, Canada
    Neuroreport 16:521-5. 2005
    ..Difficulty parsing transient differences in sounds may lead to impaired acoustic or phonological representations and subsequent language impairment in autism spectrum disorder...
  19. ncbi request reprint Cortical evidence of the perceptual backward masking effect on /l/ and /r/ sounds from a following vowel in Japanese speakers
    Sachiko Koyama
    Department of Integrative Physiology, National Institute for Physiological Sciences, Okazaki, Japan
    Neuroimage 18:962-74. 2003
    ..The MMN stimulus duration effect is thus suggested to come from the backward masking of foreign consonants by subsequent vowels...
  20. ncbi request reprint Cortical auditory system maturational abnormalities in children with autism disorder: an MEG investigation
    Nicole M Gage
    Biomagnetic Imaging Laboratory, San Francisco, CA, USA
    Brain Res Dev Brain Res 144:201-9. 2003
    ..M100 latency in RH increased slightly (at a rate of 0.8 ms/year) with age. Results provide evidence for a differential auditory system development in AD children which may reflect abnormalities in cortical maturational processes in AD...
  21. ncbi request reprint Magnetoencephalography detection of early syntactic processing in humans: comparison between L1 speakers and L2 learners of English
    Mikio Kubota
    Department of English, Seijo University, 6 1 20, Seijo, Setagaya Ku, Tokyo, 157 8511, Japan
    Neurosci Lett 353:107-10. 2003
    ....
  22. ncbi request reprint Magnetic mismatch fields elicited by vowel duration and pitch changes in Japanese words in humans: comparison between native- and non-speakers of Japanese
    Mayako Inouchi
    English Department, San Francisco State University, San Francisco, CA, USA
    Neurosci Lett 353:165-8. 2003
    ..Automatic detection of changes in vowel shortening and pitch falling is a useful index of language-non-specific auditory memory traces...
  23. doi request reprint Auditory evoked fields predict language ability and impairment in children
    Janis E Oram Cardy
    School of Communication Sciences and Disorders, University of Western Ontario, London, ON, Canada
    Int J Psychophysiol 68:170-5. 2008
    ....
  24. ncbi request reprint Vowel categorization induces departure of M100 latency from acoustic prediction
    Timothy P L Roberts
    Department of Medical Imaging, University of Toronto, 150 College Street, Toronto, Ontario M5S 3E2, Canada
    Neuroreport 15:1679-82. 2004
    ..A theory is proposed in which phonological categorization emerges from specific spatial distribution of frequency-tuned neurons...
  25. ncbi request reprint Temporal resolution properties of human auditory cortex: reflections in the neuromagnetic auditory evoked M100 component
    Nicole Gage
    Department of Cognitive Sciences, 3151 Social Science Plaza A, University of California, Irvine, CA 92697 5100, USA
    Brain Res 1069:166-71. 2006
    ..Results--40 ms masker: M100 latency and amplitude were unaffected by gaps inserted at +40 ms, providing further evidence for an M100 TWI of <40 ms...
  26. ncbi request reprint Language lateralization development in children with autism: insights from the late field magnetoencephalogram
    Elissa J Flagg
    Department of Medical Imaging, University of Toronto, 150 College St, Room 116, Toronto, Ont, Canada M5M 1G1
    Neurosci Lett 386:82-7. 2005
    ....
  27. ncbi request reprint The elicitation of phonological and semantic neuromagnetic field components by non-words in human auditory sentence comprehension
    Mayako Inouchi
    English Department, San Francisco State University, San Francisco, CA, USA
    Neurosci Lett 380:116-21. 2005
    ..The elicitations of M300 and M500 components in this study support the biphasic hypothesis where a pre-lexical phonological analysis stage precedes a post-lexical semantic integration stage in lexical recognition of a native language...
  28. ncbi request reprint Prominence of M50 auditory evoked response over M100 in childhood and autism
    Janis E Oram Cardy
    Department of Medical Imaging, University of Toronto, 150 College Street, Toronto, Ontario, M5S 2E3, Canada
    Neuroreport 15:1867-70. 2004
    ..Children with autism did not differ from control children with respect to these observations. The M50 in relation to the M100 is a robust index of early auditory system maturation suitable for future developmental investigations...
  29. ncbi request reprint Magnetoencephalography identifies rapid temporal processing deficit in autism and language impairment
    Janis E Oram Cardy
    Department of Medical Imaging, University of Toronto, The Hospital for Sick Children, Toronto, Ontario, Canada
    Neuroreport 16:329-32. 2005
    ..Rapid temporal processing impairments may be fundamentally associated with impairments in language rather than autism spectrum disorder...
  30. ncbi request reprint MEG detects neural consequences of anomalous nasalization in vowel-consonant pairs
    Elissa J Flagg
    Department of Languages, Literatures and Linguistics, S546 Ross Building, York University, 4700 Keele Street, Toronto, Ont, Canada M3J 1P3
    Neurosci Lett 397:263-8. 2006
    ....
  31. ncbi request reprint Magnetic source imaging demonstrates altered cortical distribution of function in patients with arteriovenous malformations
    G Edward Vates
    Department of Neurological Surgery, University of California, San Francisco, San Francisco, California 94143, USA
    Neurosurgery 51:614-23; discussion 623-7. 2002
    ..We used magnetic source imaging (MSI) to identify the central sulcus and to determine whether primary cortical function was shifted in a set of 30 patients. We correlated these findings with outcome after treatment...
  32. ncbi request reprint Magnetoencephalography evidence of semantic violations in auditory sentence comprehension by native speakers of Japanese
    Mayako Inouchi
    Department of English, San Francisco State University, CA, San Francisco, USA
    Neurosci Lett 331:133-7. 2002
    ..This semantic field component was labeled the 'SeF-M400'. The results suggest that auditory semantic mechanism is more sensitive to vowel-shortening violations than to vowel-lengthening violations...
  33. ncbi request reprint Neuromagnetic auditory cortex responses to duration and pitch changes in tones: cross-linguistic comparisons of human subjects in directions of acoustic changes
    Mayako Inouchi
    Department of English, San Francisco State University, CA, San Francisco, USA
    Neurosci Lett 331:138-42. 2002
    ..In summary, changes in duration shortening and pitch falling are particularly salient cues for pre-attentive auditory change detection in each hemisphere...
  34. ncbi request reprint Preoperative magnetic source imaging for brain tumor surgery: a quantitative comparison with intraoperative sensory and motor mapping
    Hagen Schiffbauer
    Department of Neurosurgery, University of Tubingen, Germany
    J Neurosurg 97:1333-42. 2002
    ....
  35. ncbi request reprint Diffusion weighted magnetic resonance imaging in stroke
    Timothy P L Roberts
    Department of Medical Imaging, University of Toronto, 150 College St Rm 88, Toronto, ON, Canada M5S 3E2
    Eur J Radiol 45:185-94. 2003
    ....
  36. ncbi request reprint Human neuronal encoding of English syntactic violations as revealed by both L1 and L2 speakers
    Mikio Kubota
    Department of English, Seijo University, 6 1 20, Seijo, Setagaya Ku, Tokyo 157 8511, Japan
    Neurosci Lett 368:235-40. 2004
    ..The findings imply that L1 and L2 speakers have similar neuronal mechanisms subserving syntactic processing of such violations...
  37. ncbi request reprint Ipsilateral representation of oral structures in human anterior parietal somatosensory cortex and integration of inputs across the midline
    Elizabeth A Disbrow
    Department of Neurology, Center for Neuroscience, University of California, Davis, Davis, California 95616, USA
    J Comp Neurol 467:487-95. 2003
    ..The distinct pattern of differential activation for uni-vs. bilateral stimulation suggests a unique neural mechanism of integration across the midline for inputs from the mouth...
  38. ncbi request reprint Human magnetoencephalographic evidence of early syntactic responses to c-selection violations of English infinitives and gerunds by L1 and L2 speakers
    Mikio Kubota
    Department of English, Seijo University, 6 1 20, Seijo, Setagaya Ku, Tokyo 157 8511, Japan
    Neurosci Lett 384:300-4. 2005
    ..g., the incorrect *I: He postponed to use it) for either group. L2 learners may possess automatic neuronal mechanisms comparable to L1 speakers for syntactic processing of infinitive c-selection violations...
  39. ncbi request reprint Neuro MR: protocols
    David J Mikulis
    Department of Medical Imaging, The University Health Network, The Toronto Western Hospital, Toronto, ON, Canada
    J Magn Reson Imaging 26:838-47. 2007
    ..An attempt was made to focus on basic clinical sequences that are available on most modern MR systems, with protocols employing generally accepted clinical imaging philosophies...
  40. ncbi request reprint Preoperative magnetic source imaging for brain tumor surgery: a quantitative comparison with intraoperative sensory and motor mapping
    Hagen Schiffbauer
    Department of Neurosurgery, University of Tubingen, Germany
    Neurosurg Focus 15:E7. 2003
    ....